IL15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.79706796
2regulation of T-helper 1 cell differentiation (GO:0045625)5.59068586
3cellular response to type I interferon (GO:0071357)5.48381965
4type I interferon signaling pathway (GO:0060337)5.48381965
5response to type I interferon (GO:0034340)5.41462590
6neutrophil activation involved in immune response (GO:0002283)5.30853273
7response to interferon-alpha (GO:0035455)5.30233582
8positive regulation of interferon-alpha production (GO:0032727)5.16300132
9regulation of interferon-alpha production (GO:0032647)4.87486494
10T-helper 1 type immune response (GO:0042088)4.82917360
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77941534
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77941534
13regulation of RIG-I signaling pathway (GO:0039535)4.75317499
14antigen processing and presentation of endogenous antigen (GO:0019883)4.75162158
15negative regulation of viral genome replication (GO:0045071)4.72203587
16immunoglobulin mediated immune response (GO:0016064)4.43306260
17response to interferon-beta (GO:0035456)4.36575424
18response to peptidoglycan (GO:0032494)4.34415703
19negative regulation of interleukin-12 production (GO:0032695)4.31731969
20myeloid dendritic cell differentiation (GO:0043011)4.19642556
21regulation of activation of Janus kinase activity (GO:0010533)4.18825064
22tryptophan catabolic process (GO:0006569)4.17441288
23indole-containing compound catabolic process (GO:0042436)4.17441288
24indolalkylamine catabolic process (GO:0046218)4.17441288
25regulation of chronic inflammatory response (GO:0002676)4.13688911
26cellular response to interferon-beta (GO:0035458)4.13165164
27NIK/NF-kappaB signaling (GO:0038061)4.07636080
28cellular response to exogenous dsRNA (GO:0071360)4.05909342
29regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.05089210
30neutrophil activation (GO:0042119)4.04771768
31positive regulation by symbiont of host defense response (GO:0052509)4.04164692
32modulation by symbiont of host defense response (GO:0052031)4.04164692
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04164692
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04164692
35positive regulation by organism of defense response of other organism involved in symbiotic interact4.04164692
36modulation by symbiont of host immune response (GO:0052553)4.04164692
37kynurenine metabolic process (GO:0070189)4.04013704
38granulocyte activation (GO:0036230)4.02513842
39positive regulation of type 2 immune response (GO:0002830)4.02226090
40natural killer cell mediated cytotoxicity (GO:0042267)4.01707985
41natural killer cell mediated immunity (GO:0002228)4.01707985
42defense response to protozoan (GO:0042832)3.98754047
43myeloid dendritic cell activation (GO:0001773)3.98701389
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.96212835
45positive regulation of interleukin-12 production (GO:0032735)3.85302579
46positive regulation of antigen processing and presentation (GO:0002579)3.82944687
47positive regulation of T-helper cell differentiation (GO:0045624)3.79950913
48cellular response to interferon-alpha (GO:0035457)3.79751130
49interferon-gamma-mediated signaling pathway (GO:0060333)3.79060739
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.73884426
51positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.72383210
52positive regulation of interferon-beta production (GO:0032728)3.72222662
53cellular response to zinc ion (GO:0071294)3.66399085
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.64931693
55regulation of vitamin D biosynthetic process (GO:0060556)3.63633306
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.62254684
57tryptophan metabolic process (GO:0006568)3.59890747
58B cell mediated immunity (GO:0019724)3.58302223
59regulation of interferon-beta biosynthetic process (GO:0045357)3.57527160
60dendritic cell differentiation (GO:0097028)3.50579094
61* positive regulation of natural killer cell differentiation (GO:0032825)3.47190526
62cellular response to virus (GO:0098586)3.45444772
63response to protozoan (GO:0001562)3.43566103
64regulation of cytokine secretion involved in immune response (GO:0002739)3.41877703
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.41439337
66positive regulation of heat generation (GO:0031652)3.41300098
67negative regulation of interleukin-17 production (GO:0032700)3.41228084
68regulation of T-helper cell differentiation (GO:0045622)3.38991591
69response to muramyl dipeptide (GO:0032495)3.38937914
70regulation of interleukin-12 biosynthetic process (GO:0045075)3.36817405
71regulation of antigen processing and presentation (GO:0002577)3.36500481
72regulation of T-helper 2 cell differentiation (GO:0045628)3.36368396
73positive regulation of gamma-delta T cell activation (GO:0046645)3.33041721
74response to host immune response (GO:0052572)3.31689345
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31689345
76monocyte chemotaxis (GO:0002548)3.31418534
77positive regulation of interleukin-1 beta secretion (GO:0050718)3.31146701
78positive regulation of T cell cytokine production (GO:0002726)3.31035078
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.27576878
80regulation of alpha-beta T cell proliferation (GO:0046640)3.26577043
81defense response to virus (GO:0051607)3.25331986
82positive regulation of interleukin-1 secretion (GO:0050716)3.25262727
83indolalkylamine metabolic process (GO:0006586)3.23944478
84regulation of interferon-gamma biosynthetic process (GO:0045072)3.22955600
85interferon-gamma secretion (GO:0072643)3.21333639
86regulation of hypersensitivity (GO:0002883)3.20535452
87positive regulation of toll-like receptor signaling pathway (GO:0034123)3.19608300
88positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.19274093
89antigen processing and presentation via MHC class Ib (GO:0002475)3.19266488
90regulation of B cell receptor signaling pathway (GO:0050855)3.18761050
91myeloid cell activation involved in immune response (GO:0002275)3.17599899
92regulation of T-helper 1 type immune response (GO:0002825)3.17223292
93regulation of interleukin-1 beta secretion (GO:0050706)3.14296454
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13738872
95positive regulation of NF-kappaB import into nucleus (GO:0042346)3.11906304
96positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.11221158
97respiratory burst (GO:0045730)3.10726667
98macrophage activation involved in immune response (GO:0002281)3.09783431
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08978709
100negative regulation of cell killing (GO:0031342)3.08978709
101T cell migration (GO:0072678)3.07560889
102cellular biogenic amine catabolic process (GO:0042402)3.06807999
103amine catabolic process (GO:0009310)3.06807999
104leukocyte mediated cytotoxicity (GO:0001909)3.05798253
105cellular response to interferon-gamma (GO:0071346)3.05361518
106regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.02632866
107regulation of interleukin-12 production (GO:0032655)3.02583559
108positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.02504345
109positive regulation of defense response to virus by host (GO:0002230)3.00935478
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00444596
111positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99388889
112response to host (GO:0075136)2.99051123
113response to host defenses (GO:0052200)2.99051123
114response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99051123
115positive regulation of chemokine biosynthetic process (GO:0045080)2.97767686
116interferon-gamma production (GO:0032609)2.97034765
117positive regulation of response to biotic stimulus (GO:0002833)2.96670498
118response to interferon-gamma (GO:0034341)2.96358055
119lymphocyte chemotaxis (GO:0048247)2.96319645
120regulation of interleukin-8 biosynthetic process (GO:0045414)2.95879412
121regulation of immunoglobulin secretion (GO:0051023)2.95864965
122positive regulation of B cell differentiation (GO:0045579)2.95388352
123germinal center formation (GO:0002467)2.93282642
124regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90989323
125regulation of chemokine biosynthetic process (GO:0045073)2.90942640
126positive regulation of T-helper 1 type immune response (GO:0002827)2.90545212
127myeloid leukocyte activation (GO:0002274)2.88302880
128regulation of vitamin metabolic process (GO:0030656)2.87732832
129positive regulation of interleukin-10 production (GO:0032733)2.86202553
130regulation of interleukin-1 secretion (GO:0050704)2.85769316
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85152988
132regulation of fever generation (GO:0031620)2.84180965
133negative regulation of T cell mediated immunity (GO:0002710)2.81456545
134negative regulation of cytokine production involved in immune response (GO:0002719)2.79160328
135regulation of T cell tolerance induction (GO:0002664)2.78182742
136negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.76608339
137* regulation of defense response to virus by host (GO:0050691)2.74570025
138positive regulation of cAMP-mediated signaling (GO:0043950)2.72192304
139regulation of interferon-beta production (GO:0032648)2.70848393
140regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70163661
141negative regulation of nitric oxide biosynthetic process (GO:0045019)2.69397562
142natural killer cell activation involved in immune response (GO:0002323)2.68648487
143regulation of heat generation (GO:0031650)2.67543774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.32584185
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.71425626
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.83218882
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.52829420
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.50313918
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.20757018
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.87671963
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36949412
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27549039
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.23086478
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.11189628
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.07536694
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97173245
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.89908436
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86607413
16GATA1_22025678_ChIP-Seq_K562_Human2.78944003
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71302037
18SCL_19346495_ChIP-Seq_HPC-7_Human2.43021242
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41927551
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.35891318
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25319669
22SPI1_23547873_ChIP-Seq_NB4_Human2.21613313
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10939353
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92823756
25MYB_26560356_Chip-Seq_TH2_Human1.87232725
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84319628
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79646565
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71971503
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68212812
30MAF_26560356_Chip-Seq_TH1_Human1.67037483
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63194881
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63194135
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.61540884
34MYB_26560356_Chip-Seq_TH1_Human1.56036844
35VDR_22108803_ChIP-Seq_LS180_Human1.55697176
36PU_27001747_Chip-Seq_BMDM_Mouse1.54928811
37VDR_24763502_ChIP-Seq_THP-1_Human1.53184346
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.51118867
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49793720
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45934126
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44982685
42ZNF274_21170338_ChIP-Seq_K562_Hela1.44927613
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44760614
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43905649
45RUNX_20019798_ChIP-Seq_JUKART_Human1.43350713
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40468276
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38503562
48* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37687533
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36583079
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36420402
51SPI1_23127762_ChIP-Seq_K562_Human1.32469798
52GATA3_26560356_Chip-Seq_TH2_Human1.30688722
53* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28132575
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28065749
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27935386
56VDR_21846776_ChIP-Seq_THP-1_Human1.26998602
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26931250
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.26741185
59IRF1_19129219_ChIP-ChIP_H3396_Human1.26185199
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25737014
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24378045
62VDR_24787735_ChIP-Seq_THP-1_Human1.24197005
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23487806
64GBX2_23144817_ChIP-Seq_PC3_Human1.23144894
65IGF1R_20145208_ChIP-Seq_DFB_Human1.23106037
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21875390
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20757662
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18123751
69ER_23166858_ChIP-Seq_MCF-7_Human1.16920710
70* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15296964
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12945651
72GATA3_27048872_Chip-Seq_THYMUS_Human1.12726529
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.11566235
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09913278
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08513951
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08444498
77* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08391834
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.08378423
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06729632
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05094236
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04518199
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03839590
83P300_19829295_ChIP-Seq_ESCs_Human1.03031150
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.02953592
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02862970
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02826645
87CDX2_22108803_ChIP-Seq_LS180_Human1.02653135
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.02600562
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02394089
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00856660
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00492758
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.99968099
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99462045
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99362555
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99055998
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.99034791
97CJUN_26792858_Chip-Seq_BT549_Human0.97656822
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96399329
99NANOG_19829295_ChIP-Seq_ESCs_Human0.96321163
100SOX2_19829295_ChIP-Seq_ESCs_Human0.96321163
101* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96101262
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96093753
103CBP_20019798_ChIP-Seq_JUKART_Human0.96093753
104UTX_26944678_Chip-Seq_JUKART_Human0.94988704
105STAT1_20625510_ChIP-Seq_HELA_Human0.93485545
106* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92776405
107* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92776405
108* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91872252
109GATA3_26560356_Chip-Seq_TH1_Human0.91713587
110* GATA1_19941827_ChIP-Seq_MEL_Mouse0.91227322
111* STAT3_23295773_ChIP-Seq_U87_Human0.88535696
112MAF_26560356_Chip-Seq_TH2_Human0.88441342
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88420128
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88389592
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87070495
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86942367
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.86942367
118OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86489550
119TP53_22573176_ChIP-Seq_HFKS_Human0.85294129
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85218624
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84920714
122AR_20517297_ChIP-Seq_VCAP_Human0.84726747
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83549276
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83281283
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82705758
126AR_25329375_ChIP-Seq_VCAP_Human0.82482159
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80325179
128* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79987039
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78344982
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78197428
131* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76099039
132TCF7_22412390_ChIP-Seq_EML_Mouse0.74844061
133* SOX2_20726797_ChIP-Seq_SW620_Human0.71130707
134ELK3_25401928_ChIP-Seq_HUVEC_Human0.69406972
135PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.68137620
136* EGR1_19032775_ChIP-ChIP_M12_Human0.65455005
137* SRF_21415370_ChIP-Seq_HL-1_Mouse0.65379074
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.63389705
139CTCF_26484167_Chip-Seq_Bcells_Mouse0.63156906
140ELK1_19687146_ChIP-ChIP_HELA_Human0.62512311
141SMRT_27268052_Chip-Seq_Bcells_Human0.61162369
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.60758199
143ETS1_22383799_ChIP-Seq_G1ME_Mouse0.60601805
144SPI1_20517297_ChIP-Seq_HL60_Human0.59389313
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58196958
146BCL6_27268052_Chip-Seq_Bcells_Human0.57997395
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.57399926
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.56922105
149TFEB_21752829_ChIP-Seq_HELA_Human0.56370621
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55887651
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.54315472
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.54315472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.41248005
2* MP0009785_altered_susceptibility_to4.13145536
3* MP0002148_abnormal_hypersensitivity_rea3.83289713
4MP0003436_decreased_susceptibility_to3.42455264
5* MP0000685_abnormal_immune_system3.38153265
6MP0005671_abnormal_response_to3.22655658
7* MP0005025_abnormal_response_to3.15101301
8MP0005000_abnormal_immune_tolerance3.12603731
9MP0003724_increased_susceptibility_to3.00524372
10* MP0005387_immune_system_phenotype2.98451636
11* MP0001790_abnormal_immune_system2.98451636
12MP0006082_CNS_inflammation2.86180715
13MP0002419_abnormal_innate_immunity2.84940981
14* MP0001800_abnormal_humoral_immune2.66621193
15* MP0002452_abnormal_antigen_presenting2.66382400
16MP0004510_myositis2.62162694
17* MP0002723_abnormal_immune_serum2.61878019
18MP0003195_calcinosis2.46011848
19* MP0001819_abnormal_immune_cell2.36412233
20MP0002166_altered_tumor_susceptibility2.32565349
21MP0002420_abnormal_adaptive_immunity2.32284434
22MP0002006_tumorigenesis2.22115945
23MP0006054_spinal_hemorrhage2.17738884
24MP0001853_heart_inflammation2.11973659
25MP0003303_peritoneal_inflammation2.04666032
26MP0009764_decreased_sensitivity_to2.01027740
27MP0005464_abnormal_platelet_physiology1.97445158
28MP0010155_abnormal_intestine_physiology1.95031247
29MP0001348_abnormal_lacrimal_gland1.87508035
30MP0002139_abnormal_hepatobiliary_system1.87296630
31MP0000716_abnormal_immune_system1.84598010
32MP0001545_abnormal_hematopoietic_system1.84547237
33MP0005397_hematopoietic_system_phenotyp1.84547237
34MP0001845_abnormal_inflammatory_respons1.84528875
35MP0002398_abnormal_bone_marrow1.81910501
36MP0005058_abnormal_lysosome_morphology1.80054190
37MP0005310_abnormal_salivary_gland1.79830089
38MP0002332_abnormal_exercise_endurance1.79598510
39MP0001533_abnormal_skeleton_physiology1.76297741
40MP0008469_abnormal_protein_level1.74517682
41MP0004947_skin_inflammation1.67143174
42MP0002405_respiratory_system_inflammati1.66242017
43MP0008004_abnormal_stomach_pH1.58923402
44MP0002138_abnormal_hepatobiliary_system1.55816901
45MP0002429_abnormal_blood_cell1.51597780
46MP0002396_abnormal_hematopoietic_system1.50588949
47MP0002163_abnormal_gland_morphology1.50560165
48MP0001501_abnormal_sleep_pattern1.46879024
49MP0000343_altered_response_to1.40436562
50MP0009333_abnormal_splenocyte_physiolog1.38820285
51MP0000689_abnormal_spleen_morphology1.38763744
52MP0003763_abnormal_thymus_physiology1.35561158
53MP0003191_abnormal_cellular_cholesterol1.35343832
54MP0001873_stomach_inflammation1.34363152
55MP0009278_abnormal_bone_marrow1.33802621
56MP0003806_abnormal_nucleotide_metabolis1.33389666
57MP0009840_abnormal_foam_cell1.32878671
58MP0004808_abnormal_hematopoietic_stem1.32446425
59* MP0002722_abnormal_immune_system1.30440963
60MP0003075_altered_response_to1.29276929
61MP0003448_altered_tumor_morphology1.27063069
62MP0002254_reproductive_system_inflammat1.26698515
63MP0004782_abnormal_surfactant_physiolog1.24895399
64MP0003172_abnormal_lysosome_physiology1.18657062
65MP0002277_abnormal_respiratory_mucosa1.16682239
66MP0003186_abnormal_redox_activity1.16496098
67MP0005174_abnormal_tail_pigmentation1.15427655
68MP0005084_abnormal_gallbladder_morpholo1.14310734
69MP0000858_altered_metastatic_potential1.12350299
70MP0003656_abnormal_erythrocyte_physiolo1.11358000
71MP0001346_abnormal_lacrimal_gland1.07128188
72MP0009763_increased_sensitivity_to1.07007838
73MP0003950_abnormal_plasma_membrane1.06551525
74MP0002998_abnormal_bone_remodeling0.99247861
75MP0000490_abnormal_crypts_of0.96998668
76MP0003828_pulmonary_edema0.95854184
77MP0003045_fibrosis0.90986755
78MP0002837_dystrophic_cardiac_calcinosis0.89333146
79MP0005451_abnormal_body_composition0.88901937
80MP0005166_decreased_susceptibility_to0.88620501
81MP0008875_abnormal_xenobiotic_pharmacok0.88226430
82MP0005167_abnormal_blood-brain_barrier0.87844948
83MP0003866_abnormal_defecation0.87364520
84MP0005379_endocrine/exocrine_gland_phen0.87261602
85MP0004043_abnormal_pH_regulation0.85840529
86MP0005266_abnormal_metabolism0.84053694
87MP0003252_abnormal_bile_duct0.81931069
88MP0004883_abnormal_blood_vessel0.80910743
89MP0010307_abnormal_tumor_latency0.80595310
90MP0001542_abnormal_bone_strength0.78603861
91MP0003300_gastrointestinal_ulcer0.75217615
92MP0005390_skeleton_phenotype0.74132981
93MP0000230_abnormal_systemic_arterial0.73766602
94* MP0000703_abnormal_thymus_morphology0.71800126
95MP0005647_abnormal_sex_gland0.70805628
96MP0000249_abnormal_blood_vessel0.70513665
97MP0003183_abnormal_peptide_metabolism0.69016927
98MP0001764_abnormal_homeostasis0.68577919
99MP0001881_abnormal_mammary_gland0.68292002
100MP0000569_abnormal_digit_pigmentation0.67900520
101MP0005410_abnormal_fertilization0.67745780
102MP0000371_diluted_coat_color0.67416950
103MP0003646_muscle_fatigue0.67164208
104MP0005535_abnormal_body_temperature0.66537131
105MP0010386_abnormal_urinary_bladder0.65901037
106MP0003943_abnormal_hepatobiliary_system0.65587261
107MP0010352_gastrointestinal_tract_polyps0.65397924
108MP0008057_abnormal_DNA_replication0.63131563
109MP0001879_abnormal_lymphatic_vessel0.62883885
110MP0005164_abnormal_response_to0.62344902
111MP0003091_abnormal_cell_migration0.62166485
112MP0009765_abnormal_xenobiotic_induced0.61199603
113MP0003690_abnormal_glial_cell0.60815050
114MP0005376_homeostasis/metabolism_phenot0.60372678
115MP0003221_abnormal_cardiomyocyte_apopto0.59674084
116MP0002933_joint_inflammation0.58560124
117MP0002136_abnormal_kidney_physiology0.57650952
118MP0005365_abnormal_bile_salt0.56762682
119MP0005584_abnormal_enzyme/coenzyme_acti0.56729441
120MP0003566_abnormal_cell_adhesion0.56573311
121MP0000604_amyloidosis0.56300274
122MP0002019_abnormal_tumor_incidence0.54238670
123MP0002693_abnormal_pancreas_physiology0.53461389
124MP0005319_abnormal_enzyme/_coenzyme0.51755248
125MP0001663_abnormal_digestive_system0.51383013
126MP0003453_abnormal_keratinocyte_physiol0.49625191
127MP0005165_increased_susceptibility_to0.49212964
128MP0000465_gastrointestinal_hemorrhage0.47431103
129MP0000015_abnormal_ear_pigmentation0.46641290
130MP0000767_abnormal_smooth_muscle0.46511579

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.00937635
2Recurrent bacterial skin infections (HP:0005406)5.84318416
3Elevated erythrocyte sedimentation rate (HP:0003565)5.46353779
4Eczematoid dermatitis (HP:0000976)5.38549891
5Autoimmune thrombocytopenia (HP:0001973)5.30402742
6Increased IgM level (HP:0003496)4.99268510
7Myositis (HP:0100614)4.64370386
8Abnormality of macrophages (HP:0004311)4.48214045
9Chronic otitis media (HP:0000389)4.09580378
10Recurrent gram-negative bacterial infections (HP:0005420)4.09213094
11Orchitis (HP:0100796)4.05010070
12Abnormality of glycolipid metabolism (HP:0010969)4.03556433
13Abnormality of liposaccharide metabolism (HP:0010968)4.03556433
14Abnormality of glycosphingolipid metabolism (HP:0004343)4.03556433
15Mediastinal lymphadenopathy (HP:0100721)4.03480410
16Vasculitis (HP:0002633)4.00987185
17Retrobulbar optic neuritis (HP:0100654)3.92127887
18Optic neuritis (HP:0100653)3.92127887
19Recurrent fungal infections (HP:0002841)3.88979772
20Recurrent skin infections (HP:0001581)3.85728103
21Recurrent viral infections (HP:0004429)3.83555021
22Hypergammaglobulinemia (HP:0010702)3.80150135
23Basal ganglia calcification (HP:0002135)3.78295286
24Vacuolated lymphocytes (HP:0001922)3.60324849
25Thrombocytosis (HP:0001894)3.57599008
26Systemic lupus erythematosus (HP:0002725)3.23530774
27Tetraparesis (HP:0002273)3.20941718
28Autoimmune hemolytic anemia (HP:0001890)3.11497142
29Interstitial pulmonary disease (HP:0006530)3.10527937
30Petechiae (HP:0000967)3.06677196
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.05120515
32Cellulitis (HP:0100658)3.01373252
33Periodontitis (HP:0000704)2.97139132
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.96275692
35Gastrointestinal infarctions (HP:0005244)2.92560828
36Gingivitis (HP:0000230)2.91055715
37Chronic mucocutaneous candidiasis (HP:0002728)2.90816283
38Recurrent cutaneous fungal infections (HP:0011370)2.90816283
39Obstructive lung disease (HP:0006536)2.89770434
40Chronic obstructive pulmonary disease (HP:0006510)2.89770434
41Nasal polyposis (HP:0100582)2.86865990
42Gangrene (HP:0100758)2.81812231
43Abnormality of the nasal mucosa (HP:0000433)2.80739455
44Abnormality of T cell number (HP:0011839)2.80669584
45Arterial thrombosis (HP:0004420)2.80069464
46Pulmonary infiltrates (HP:0002113)2.79867381
47Abnormality of T cell physiology (HP:0011840)2.78848847
48Increased cerebral lipofuscin (HP:0011813)2.73089205
49Meningitis (HP:0001287)2.72364359
50Porencephaly (HP:0002132)2.71540286
51Stomatitis (HP:0010280)2.66144028
52Dysostosis multiplex (HP:0000943)2.63450440
53Gingival bleeding (HP:0000225)2.61294907
54Urticaria (HP:0001025)2.60468806
55Hemoptysis (HP:0002105)2.59798878
56T lymphocytopenia (HP:0005403)2.56424140
57Abnormality of B cell number (HP:0010975)2.56394471
58Pustule (HP:0200039)2.54774677
59Recurrent pneumonia (HP:0006532)2.52830166
60Parakeratosis (HP:0001036)2.51670743
61Increased serum ferritin (HP:0003281)2.51505577
62Vertebral compression fractures (HP:0002953)2.48910643
63Recurrent bronchitis (HP:0002837)2.48332470
64Disinhibition (HP:0000734)2.47164684
65Stomach cancer (HP:0012126)2.46069708
66Leukocytosis (HP:0001974)2.44652426
67Recurrent lower respiratory tract infections (HP:0002783)2.44642077
68Agammaglobulinemia (HP:0004432)2.44235043
69Abnormality of transition element cation homeostasis (HP:0011030)2.43715335
70Increased IgE level (HP:0003212)2.43660451
71Eosinophilia (HP:0001880)2.42937256
72Hematochezia (HP:0002573)2.39482090
73Alveolar cell carcinoma (HP:0006519)2.38135329
74Keratoconjunctivitis sicca (HP:0001097)2.34117073
75Abnormality of iron homeostasis (HP:0011031)2.34103326
76Poor head control (HP:0002421)2.33845601
77Colitis (HP:0002583)2.29040821
78Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28198700
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28198700
80Abnormality of polysaccharide metabolism (HP:0011012)2.28198700
81Keratoconjunctivitis (HP:0001096)2.27832118
82Episodic fever (HP:0001954)2.24385485
83Neoplasm of the tracheobronchial system (HP:0100552)2.24066766
84Polyneuropathy (HP:0001271)2.23489369
85Keratitis (HP:0000491)2.22278705
86Osteomyelitis (HP:0002754)2.21839402
87Chronic sinusitis (HP:0011109)2.21720368
88Neutropenia (HP:0001875)2.20792064
89Joint swelling (HP:0001386)2.20001121
90Abnormality of T cells (HP:0002843)2.18750049
91Abnormality of the prostate (HP:0008775)2.17974985
92IgG deficiency (HP:0004315)2.17458208
93Prostate neoplasm (HP:0100787)2.17129694
94IgA deficiency (HP:0002720)2.16909813
95Epistaxis (HP:0000421)2.16085709
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15781437
97Granulocytopenia (HP:0001913)2.15155740
98Chest pain (HP:0100749)2.13841235
99Purpura (HP:0000979)2.13430298
100Axonal loss (HP:0003447)2.12128667
101Inflammation of the large intestine (HP:0002037)2.11804069
102Premature loss of primary teeth (HP:0006323)2.11425423
103Spontaneous hematomas (HP:0007420)2.10367149
104Encephalitis (HP:0002383)2.09339100
105Abnormality of cells of the lymphoid lineage (HP:0012140)2.09272411
106Loss of speech (HP:0002371)2.08500569
107Abnormality of the pericardium (HP:0001697)2.07846121
108Mutism (HP:0002300)2.07578914
109Reduced antithrombin III activity (HP:0001976)2.07305702
110Abnormality of eosinophils (HP:0001879)2.06078940
111Thick nail (HP:0001805)2.06071324
112Amaurosis fugax (HP:0100576)2.05584720
113Abnormality of the pleura (HP:0002103)2.04760377
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03233094
115Gastrointestinal inflammation (HP:0004386)2.02897506
116Anorexia (HP:0002039)2.02540706
117Panhypogammaglobulinemia (HP:0003139)2.01807622
118Mucopolysacchariduria (HP:0008155)1.99885147
119Urinary glycosaminoglycan excretion (HP:0003541)1.99885147
120Skin ulcer (HP:0200042)1.99481830
121Cleft eyelid (HP:0000625)1.98579058
122Pulmonary embolism (HP:0002204)1.96278332
123Abnormality of lateral ventricle (HP:0030047)1.95858545
124Prolonged bleeding time (HP:0003010)1.95339100
125Nausea (HP:0002018)1.94881490
126Neoplasm of head and neck (HP:0012288)1.94350748
127Esophageal neoplasm (HP:0100751)1.94350748
128Chronic diarrhea (HP:0002028)1.94047345
129Albinism (HP:0001022)1.94013895
130Abnormality of the basal ganglia (HP:0002134)1.93971261
131Vertigo (HP:0002321)1.93315598
132B lymphocytopenia (HP:0010976)1.93157933
133Abnormality of the endocardium (HP:0004306)1.82571731
134Abolished electroretinogram (ERG) (HP:0000550)1.75815799
135Pancreatic cysts (HP:0001737)1.71967085
136Abnormality of the renal cortex (HP:0011035)1.71009383
1373-Methylglutaconic aciduria (HP:0003535)1.69612584
138Hyperventilation (HP:0002883)1.69547149
139Inappropriate behavior (HP:0000719)1.69303046
140Pancreatitis (HP:0001733)1.67512289
141Metaphyseal irregularity (HP:0003025)1.64729884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.12297981
2TYK24.04603312
3FRK3.92466407
4TBK13.77269791
5IKBKE3.19249130
6JAK33.16609858
7IRAK43.13740186
8PIM22.94068164
9IKBKB2.85657386
10KIT2.80536107
11JAK12.40015395
12RIPK42.37329542
13BLK2.36177505
14MAP3K132.33250190
15PBK2.06192712
16IRAK32.04200050
17TIE11.91171631
18MAP4K11.87120454
19CHUK1.76741741
20TEC1.75322403
21FLT31.63889974
22TXK1.62193665
23BTK1.62173898
24TLK11.56313686
25SYK1.55868903
26NME21.53623203
27ZAP701.41372729
28INSRR1.38195864
29EIF2AK21.36295278
30BMPR21.31019882
31CSF1R1.30410638
32FGFR41.26318783
33TRIM281.25312530
34MATK1.24194768
35ERN11.21642686
36EPHB11.17109111
37ARAF1.14310150
38NEK91.13828149
39TAOK21.12361027
40PIM11.11671338
41MST41.10346473
42HCK1.10059670
43TRPM71.10043900
44DAPK21.09523121
45IRAK11.08409733
46TAOK31.07651516
47TNIK1.07466925
48NLK1.07433043
49MAP3K31.07090940
50FGR1.07076068
51MAP4K21.06799316
52RPS6KA41.06576080
53TGFBR21.06293038
54EPHA31.06125401
55FGFR31.04886302
56ZAK1.00142839
57LYN0.99715336
58LCK0.96895808
59CSK0.95872535
60TGFBR10.92152270
61STK40.88041882
62JAK20.87276454
63OXSR10.79682644
64MAP3K120.76488745
65FES0.76013594
66ACVR1B0.74117082
67DDR20.72641156
68KDR0.72322611
69GRK10.72071493
70PINK10.71743430
71PKN10.70026240
72ABL20.69976382
73ADRBK20.67192270
74TNK20.67112427
75ADRBK10.66055246
76MAP3K50.63604823
77PRKCD0.62523874
78MYLK0.61604560
79CDC42BPA0.60249076
80MAPK70.60178999
81BMX0.57708870
82SIK30.56851339
83STK100.56360599
84YES10.56203150
85ERBB30.54188228
86IRAK20.52843326
87MUSK0.51096889
88LRRK20.50834797
89MAP2K30.49916835
90MAPKAPK20.49411770
91STK160.48773029
92PTK2B0.47763869
93GRK70.46844891
94MELK0.46395385
95MAP3K110.46154851
96ABL10.45671700
97PDK20.45238173
98MOS0.44089226
99TAOK10.41649772
100FER0.41582782
101BMPR1B0.41582639
102IGF1R0.40326885
103GRK60.40252005
104PRKCQ0.39049124
105HIPK20.39024883
106PDK10.38856147
107CAMKK20.37200313
108RPS6KA50.36888906
109BCKDK0.36464880
110RIPK10.35727644
111MAPK110.35691694
112CAMK1D0.34354564
113GRK50.34297062
114PRKCE0.34203143
115DYRK30.34104930
116MAP2K60.33976734
117PRKG20.33862897
118TAF10.33567474
119PTK60.32106083
120STK240.31287317
121RPS6KA60.30820467
122RAF10.29744700
123STK30.29009558
124PRKAA20.28596054
125TTN0.28411814
126EGFR0.26267015
127DAPK30.25468586
128NUAK10.25338688
129ITK0.24284258
130RPS6KA10.22829545
131PIK3CG0.22316113
132MARK30.21270670
133BCR0.20275793
134DYRK1B0.19365493
135EIF2AK30.17720821
136EIF2AK10.16193189

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.01195364
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.59804770
3Graft-versus-host disease_Homo sapiens_hsa053323.46106889
4Toll-like receptor signaling pathway_Homo sapiens_hsa046203.12244994
5Leishmaniasis_Homo sapiens_hsa051403.04406248
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.04258474
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.74954238
8Measles_Homo sapiens_hsa051622.62359644
9* Intestinal immune network for IgA production_Homo sapiens_hsa046722.55796654
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.45352205
11Influenza A_Homo sapiens_hsa051642.31386768
12Legionellosis_Homo sapiens_hsa051342.18350418
13Autoimmune thyroid disease_Homo sapiens_hsa053202.16058258
14Type I diabetes mellitus_Homo sapiens_hsa049402.13460917
15Pertussis_Homo sapiens_hsa051332.12878071
16* Herpes simplex infection_Homo sapiens_hsa051682.09123053
17Staphylococcus aureus infection_Homo sapiens_hsa051502.02443267
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00489779
19Asthma_Homo sapiens_hsa053101.98945708
20Osteoclast differentiation_Homo sapiens_hsa043801.95425993
21Malaria_Homo sapiens_hsa051441.91682007
22* TNF signaling pathway_Homo sapiens_hsa046681.84028405
23African trypanosomiasis_Homo sapiens_hsa051431.83216987
24Toxoplasmosis_Homo sapiens_hsa051451.78541765
25Tuberculosis_Homo sapiens_hsa051521.66083883
26Primary immunodeficiency_Homo sapiens_hsa053401.64348434
27* Rheumatoid arthritis_Homo sapiens_hsa053231.61430002
28Antigen processing and presentation_Homo sapiens_hsa046121.58770405
29Viral myocarditis_Homo sapiens_hsa054161.54107538
30* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50702191
31* Jak-STAT signaling pathway_Homo sapiens_hsa046301.50033171
32Apoptosis_Homo sapiens_hsa042101.41240419
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39172645
34Salmonella infection_Homo sapiens_hsa051321.33591908
35B cell receptor signaling pathway_Homo sapiens_hsa046621.32769800
36Chemokine signaling pathway_Homo sapiens_hsa040621.27303660
37Caffeine metabolism_Homo sapiens_hsa002321.26994310
38Tryptophan metabolism_Homo sapiens_hsa003801.25991626
39Shigellosis_Homo sapiens_hsa051311.25563288
40Hepatitis C_Homo sapiens_hsa051601.20952710
41Hepatitis B_Homo sapiens_hsa051611.16241613
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14162405
43Hematopoietic cell lineage_Homo sapiens_hsa046401.10683072
44Other glycan degradation_Homo sapiens_hsa005110.98440261
45Acute myeloid leukemia_Homo sapiens_hsa052210.88871898
46Lysosome_Homo sapiens_hsa041420.88522771
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82914972
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82870984
49Phagosome_Homo sapiens_hsa041450.82774759
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81583662
51Proteasome_Homo sapiens_hsa030500.80415939
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77167367
53Prolactin signaling pathway_Homo sapiens_hsa049170.73794654
54Dorso-ventral axis formation_Homo sapiens_hsa043200.73227086
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.72891168
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72744181
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71671761
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69989814
59Sulfur metabolism_Homo sapiens_hsa009200.69598547
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68970904
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68462139
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67298483
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66474747
64Epstein-Barr virus infection_Homo sapiens_hsa051690.63634490
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.61506314
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59055783
67Ribosome_Homo sapiens_hsa030100.58451325
68Amoebiasis_Homo sapiens_hsa051460.55798215
69Platelet activation_Homo sapiens_hsa046110.55347887
70Linoleic acid metabolism_Homo sapiens_hsa005910.54769151
71Small cell lung cancer_Homo sapiens_hsa052220.53632309
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.51417146
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50899768
74T cell receptor signaling pathway_Homo sapiens_hsa046600.50260918
75Collecting duct acid secretion_Homo sapiens_hsa049660.46498307
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45749147
77Chronic myeloid leukemia_Homo sapiens_hsa052200.45191133
78HIF-1 signaling pathway_Homo sapiens_hsa040660.44698100
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44390277
80Sphingolipid metabolism_Homo sapiens_hsa006000.44176403
81p53 signaling pathway_Homo sapiens_hsa041150.43945304
82Ether lipid metabolism_Homo sapiens_hsa005650.41047143
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39998808
84Type II diabetes mellitus_Homo sapiens_hsa049300.38954651
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38599338
86Viral carcinogenesis_Homo sapiens_hsa052030.38070690
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37163779
88Phototransduction_Homo sapiens_hsa047440.36850338
89Pancreatic cancer_Homo sapiens_hsa052120.35829933
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35438668
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33505295
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30457847
93Prion diseases_Homo sapiens_hsa050200.29693059
94Mineral absorption_Homo sapiens_hsa049780.27287015
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26003359
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25545180
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.24737707
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.24708071
99Chemical carcinogenesis_Homo sapiens_hsa052040.24294334
100Regulation of autophagy_Homo sapiens_hsa041400.21838224
101Notch signaling pathway_Homo sapiens_hsa043300.20605390
102Base excision repair_Homo sapiens_hsa034100.19203068
103Systemic lupus erythematosus_Homo sapiens_hsa053220.18666274
104Renin-angiotensin system_Homo sapiens_hsa046140.18624892
105DNA replication_Homo sapiens_hsa030300.18612164
106* HTLV-I infection_Homo sapiens_hsa051660.18274116
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17886603
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.17810072
109Ovarian steroidogenesis_Homo sapiens_hsa049130.17396222
110Glycerolipid metabolism_Homo sapiens_hsa005610.17066181
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16561261
112MAPK signaling pathway_Homo sapiens_hsa040100.15671678
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.13987733
114Insulin resistance_Homo sapiens_hsa049310.13712306
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12431676
116Folate biosynthesis_Homo sapiens_hsa007900.11946382
117Galactose metabolism_Homo sapiens_hsa000520.10984646
118Olfactory transduction_Homo sapiens_hsa047400.09881325
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08955142
120ABC transporters_Homo sapiens_hsa020100.08938866
121Arachidonic acid metabolism_Homo sapiens_hsa005900.08410124
122Peroxisome_Homo sapiens_hsa041460.08213580
123Complement and coagulation cascades_Homo sapiens_hsa046100.07770987
124Pentose phosphate pathway_Homo sapiens_hsa000300.04273801
125Pyrimidine metabolism_Homo sapiens_hsa002400.03843310

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