IL15RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.62842566
2regulation of chronic inflammatory response (GO:0002676)4.95989374
3regulation of vitamin metabolic process (GO:0030656)4.64467049
4negative regulation of interleukin-12 production (GO:0032695)4.56160229
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36949632
6antigen processing and presentation of endogenous antigen (GO:0019883)4.32484158
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29710243
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29710243
9indole-containing compound catabolic process (GO:0042436)4.16070072
10indolalkylamine catabolic process (GO:0046218)4.16070072
11tryptophan catabolic process (GO:0006569)4.16070072
12response to peptidoglycan (GO:0032494)4.07252435
13regulation of cytokine secretion involved in immune response (GO:0002739)4.06384654
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.02585764
15aromatic amino acid family catabolic process (GO:0009074)4.02236344
16L-phenylalanine catabolic process (GO:0006559)3.95797368
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95797368
18lipopolysaccharide-mediated signaling pathway (GO:0031663)3.95019582
19kynurenine metabolic process (GO:0070189)3.93763298
20positive regulation of chemokine biosynthetic process (GO:0045080)3.93615692
21cellular response to type I interferon (GO:0071357)3.91979589
22type I interferon signaling pathway (GO:0060337)3.91979589
23response to type I interferon (GO:0034340)3.90590748
24tryptophan metabolic process (GO:0006568)3.88586037
25regulation of chemokine biosynthetic process (GO:0045073)3.84044427
26positive regulation of type 2 immune response (GO:0002830)3.81798328
27regulation of cholesterol esterification (GO:0010872)3.81715753
28defense response to protozoan (GO:0042832)3.77693210
29positive regulation of gamma-delta T cell activation (GO:0046645)3.77551853
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.76655009
31L-phenylalanine metabolic process (GO:0006558)3.76655009
32phospholipid efflux (GO:0033700)3.70066752
33regulation of podosome assembly (GO:0071801)3.69998335
34immunoglobulin mediated immune response (GO:0016064)3.69360163
35response to protozoan (GO:0001562)3.66891620
36high-density lipoprotein particle remodeling (GO:0034375)3.62901732
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.62806161
38regulation of RIG-I signaling pathway (GO:0039535)3.59805594
39response to interferon-alpha (GO:0035455)3.58214102
40positive regulation of interferon-alpha production (GO:0032727)3.52360374
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.49594183
42low-density lipoprotein particle remodeling (GO:0034374)3.46068842
43positive regulation of heat generation (GO:0031652)3.45545119
44macrophage activation involved in immune response (GO:0002281)3.44404652
45positive regulation of T-helper cell differentiation (GO:0045624)3.42596495
46NAD biosynthetic process (GO:0009435)3.42577187
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.41886776
48positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.41525309
49T-helper 1 type immune response (GO:0042088)3.41480864
50regulation of T-helper cell differentiation (GO:0045622)3.38800291
51NIK/NF-kappaB signaling (GO:0038061)3.38701348
52regulation of activation of Janus kinase activity (GO:0010533)3.37287346
53urea cycle (GO:0000050)3.36661846
54urea metabolic process (GO:0019627)3.36661846
55positive regulation of NF-kappaB import into nucleus (GO:0042346)3.35196128
56regulation of triglyceride catabolic process (GO:0010896)3.34865950
57regulation of interleukin-12 production (GO:0032655)3.34740555
58regulation of mononuclear cell migration (GO:0071675)3.34380343
59regulation of fever generation (GO:0031620)3.33733952
60complement activation, alternative pathway (GO:0006957)3.33451256
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33329173
62positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.32148286
63bile acid biosynthetic process (GO:0006699)3.31741199
64alpha-linolenic acid metabolic process (GO:0036109)3.31342882
65peptidyl-glutamic acid carboxylation (GO:0017187)3.30709928
66protein carboxylation (GO:0018214)3.30709928
67regulation of immunoglobulin secretion (GO:0051023)3.30279689
68negative regulation of cytokine production involved in immune response (GO:0002719)3.29963335
69regulation of interferon-alpha production (GO:0032647)3.29376293
70positive regulation of defense response to virus by host (GO:0002230)3.29021817
71protein-lipid complex remodeling (GO:0034368)3.28611361
72macromolecular complex remodeling (GO:0034367)3.28611361
73plasma lipoprotein particle remodeling (GO:0034369)3.28611361
74negative regulation of nitric oxide biosynthetic process (GO:0045019)3.24890146
75regulation of interleukin-8 biosynthetic process (GO:0045414)3.24731497
76regulation of T-helper 1 cell differentiation (GO:0045625)3.24567832
77reverse cholesterol transport (GO:0043691)3.22766784
78myeloid dendritic cell activation (GO:0001773)3.20238219
79germinal center formation (GO:0002467)3.19312020
80regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.18800485
81modulation of growth of symbiont involved in interaction with host (GO:0044144)3.16880314
82regulation of growth of symbiont in host (GO:0044126)3.16880314
83negative regulation of growth of symbiont in host (GO:0044130)3.16880314
84negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.16880314
85nicotinamide nucleotide biosynthetic process (GO:0019359)3.16835438
86pyridine nucleotide biosynthetic process (GO:0019363)3.16835438
87regulation of interferon-beta biosynthetic process (GO:0045357)3.14920794
88regulation of T cell tolerance induction (GO:0002664)3.13983795
89phospholipid homeostasis (GO:0055091)3.13248511
90regulation of membrane protein ectodomain proteolysis (GO:0051043)3.13180098
91negative regulation of viral genome replication (GO:0045071)3.10748128
92regulation of antigen processing and presentation (GO:0002577)3.09918906
93positive regulation of humoral immune response (GO:0002922)3.09487080
94nitrogen cycle metabolic process (GO:0071941)3.09187479
95dendritic cell differentiation (GO:0097028)3.08633349
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.07689711
97plasma lipoprotein particle clearance (GO:0034381)3.07653893
98branching involved in labyrinthine layer morphogenesis (GO:0060670)3.07611974
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07105060
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05779113
101valine metabolic process (GO:0006573)3.04977254
102cellular response to interferon-gamma (GO:0071346)3.04884002
103cellular response to exogenous dsRNA (GO:0071360)3.04436022
104negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.04303029
105glyoxylate metabolic process (GO:0046487)3.04005010
106response to interferon-beta (GO:0035456)3.02169731
107regulation of type 2 immune response (GO:0002828)2.99556252
108response to interferon-gamma (GO:0034341)2.96329382
109regulation of protein activation cascade (GO:2000257)2.96178489
110cellular response to lipopolysaccharide (GO:0071222)2.95817301
111interferon-gamma secretion (GO:0072643)2.95499590
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93702686
113neutrophil activation involved in immune response (GO:0002283)2.92945833
114regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.92010142
115regulation of interleukin-2 biosynthetic process (GO:0045076)2.91965511
116amine catabolic process (GO:0009310)2.91837243
117cellular biogenic amine catabolic process (GO:0042402)2.91837243
118positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.91066356
119* positive regulation of natural killer cell differentiation (GO:0032825)2.90924980
120regulation of nitric oxide biosynthetic process (GO:0045428)2.90633275
121cellular response to interferon-beta (GO:0035458)2.90563062
122cholesterol efflux (GO:0033344)2.90106649
123regulation of hypersensitivity (GO:0002883)2.89790101
124indolalkylamine metabolic process (GO:0006586)2.89316630
125sulfur amino acid catabolic process (GO:0000098)2.88492399
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88069377
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.88069377
128modulation by symbiont of host immune response (GO:0052553)2.88069377
129positive regulation by symbiont of host defense response (GO:0052509)2.88069377
130modulation by symbiont of host defense response (GO:0052031)2.88069377
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88069377
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87940968
133positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.86934139
134cellular response to molecule of bacterial origin (GO:0071219)2.86263104
135regulation of inflammatory response to antigenic stimulus (GO:0002861)2.86237159
136acute-phase response (GO:0006953)2.85169451
137regulation of T-helper 1 type immune response (GO:0002825)2.85087482
138T cell migration (GO:0072678)2.85086960
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84823907
140positive regulation of nitric oxide biosynthetic process (GO:0045429)2.83044455
141regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.83040377
142positive regulation of interferon-beta production (GO:0032728)2.82033498
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82013265
144negative regulation of cell killing (GO:0031342)2.82013265
145positive regulation of antigen processing and presentation (GO:0002579)2.81574894
146cellular response to interferon-alpha (GO:0035457)2.80760195
147monocyte chemotaxis (GO:0002548)2.80578553
148B cell mediated immunity (GO:0019724)2.80308820
149regulation of response to interferon-gamma (GO:0060330)2.80163146
150aromatic amino acid family metabolic process (GO:0009072)2.79809824
151regulation of fibrinolysis (GO:0051917)2.79174683
152mature B cell differentiation involved in immune response (GO:0002313)2.77780170
153amino-acid betaine metabolic process (GO:0006577)2.77274284
154negative regulation of lipid storage (GO:0010888)2.77114444
155negative regulation of cholesterol transport (GO:0032375)2.77052588
156negative regulation of sterol transport (GO:0032372)2.77052588
157homocysteine metabolic process (GO:0050667)2.76907318
158negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.75475807
159negative regulation of fibrinolysis (GO:0051918)2.74890878
160bile acid metabolic process (GO:0008206)2.74826843
161regulation of complement activation (GO:0030449)2.74800910
162positive regulation of lipid catabolic process (GO:0050996)2.74169425
163triglyceride homeostasis (GO:0070328)2.71360549
164acylglycerol homeostasis (GO:0055090)2.71360549
165myeloid dendritic cell differentiation (GO:0043011)2.68604617
166positive regulation of interleukin-12 production (GO:0032735)2.68314347
167natural killer cell mediated cytotoxicity (GO:0042267)2.67631299
168natural killer cell mediated immunity (GO:0002228)2.67631299
169opsonization (GO:0008228)2.66966936
170plasma lipoprotein particle organization (GO:0071827)2.64963081
171interferon-gamma-mediated signaling pathway (GO:0060333)2.63939987
172cysteine metabolic process (GO:0006534)2.63475496
173regulation of cholesterol storage (GO:0010885)2.62547417
174plasma lipoprotein particle assembly (GO:0034377)2.55983694
175hydrogen peroxide biosynthetic process (GO:0050665)2.55051986
176regulation of interleukin-12 biosynthetic process (GO:0045075)2.54959179
1772-oxoglutarate metabolic process (GO:0006103)2.52931508
178benzene-containing compound metabolic process (GO:0042537)2.52646059
179cofactor catabolic process (GO:0051187)2.52250005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.69828240
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.41090120
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.95280414
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.64139271
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.50670223
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.39445107
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.21877787
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09601918
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.04224610
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.66540420
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.19791465
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.09781849
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.06943616
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02056499
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.72871954
16GATA1_22025678_ChIP-Seq_K562_Human2.63916252
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.56968181
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.52010394
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43854948
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29980527
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.23482262
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22885955
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15463717
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12387140
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07938656
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03174333
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96527409
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88431295
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77688994
30* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74143540
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73411614
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72539137
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70122709
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68976836
35VDR_21846776_ChIP-Seq_THP-1_Human1.68759521
36SCL_19346495_ChIP-Seq_HPC-7_Human1.44395658
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.42669717
38RUNX_20019798_ChIP-Seq_JUKART_Human1.33989144
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26961056
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24832641
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23625985
42VDR_24787735_ChIP-Seq_THP-1_Human1.22212187
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21041827
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.20334245
45UTX_26944678_Chip-Seq_JUKART_Human1.18755017
46MAF_26560356_Chip-Seq_TH2_Human1.17962674
47MYB_26560356_Chip-Seq_TH2_Human1.17330526
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17232547
49GATA1_19941826_ChIP-Seq_K562_Human1.13323318
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12057723
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.11534410
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10838445
53LXR_22292898_ChIP-Seq_THP-1_Human1.10793511
54STAT1_20625510_ChIP-Seq_HELA_Human1.10129874
55PU_27001747_Chip-Seq_BMDM_Mouse1.08330603
56* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07176817
57SPI1_23547873_ChIP-Seq_NB4_Human1.06205851
58* MYB_26560356_Chip-Seq_TH1_Human1.05986063
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05609097
60* MAF_26560356_Chip-Seq_TH1_Human1.05590344
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03047946
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02583290
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02568674
64* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01893417
65GATA3_26560356_Chip-Seq_TH2_Human1.01256462
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.00818249
67EGR1_19032775_ChIP-ChIP_M12_Human1.00035037
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99523295
69* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99063904
70* KDM2B_26808549_Chip-Seq_DND41_Human0.96502062
71TCF7_22412390_ChIP-Seq_EML_Mouse0.96139618
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95999350
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93304932
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93075810
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92877774
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92652681
77* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92405256
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92158239
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91809273
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90847996
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89534689
82* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88401869
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88135806
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88125599
85MYC_22102868_ChIP-Seq_BL_Human0.87699317
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87453499
87EGR1_19374776_ChIP-ChIP_THP-1_Human0.85415683
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85341334
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85231019
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.85108447
91BCOR_27268052_Chip-Seq_Bcells_Human0.84024264
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83555419
93VDR_24763502_ChIP-Seq_THP-1_Human0.82886214
94BCL6_27268052_Chip-Seq_Bcells_Human0.82556878
95* SOX2_20726797_ChIP-Seq_SW620_Human0.82376675
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.81875331
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81817861
98CLOCK_20551151_ChIP-Seq_293T_Human0.81268294
99RUNX1_22412390_ChIP-Seq_EML_Mouse0.80538628
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80429463
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79943761
102GATA3_27048872_Chip-Seq_THYMUS_Human0.79611337
103TFEB_21752829_ChIP-Seq_HELA_Human0.77960088
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77777775
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77777775
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74289543
107SMAD_19615063_ChIP-ChIP_OVARY_Human0.73771893
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73005861
109* FOXA2_19822575_ChIP-Seq_HepG2_Human0.71775381
110* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70449413
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68006928
112* GATA4_25053715_ChIP-Seq_YYC3_Human0.66077321
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65919801
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.65783428
115SPI1_23127762_ChIP-Seq_K562_Human0.65698273
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.64694988
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64661673
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.63642973
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63333420
120HTT_18923047_ChIP-ChIP_STHdh_Human0.62987618
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60980252
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.60537546
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.60408298
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60026547
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.59664411
126* GATA2_19941826_ChIP-Seq_K562_Human0.59315598
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.58140585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.38444128
2MP0005360_urolithiasis3.87171650
3MP0001835_abnormal_antigen_presentation3.61250207
4MP0005365_abnormal_bile_salt3.35729289
5MP0005085_abnormal_gallbladder_physiolo3.34418648
6MP0000685_abnormal_immune_system3.00227121
7MP0009785_altered_susceptibility_to2.98451599
8MP0002254_reproductive_system_inflammat2.87689573
9MP0002138_abnormal_hepatobiliary_system2.75440714
10MP0003724_increased_susceptibility_to2.74062447
11MP0009840_abnormal_foam_cell2.63001852
12MP0008875_abnormal_xenobiotic_pharmacok2.57801784
13MP0002148_abnormal_hypersensitivity_rea2.54715580
14MP0003436_decreased_susceptibility_to2.53833080
15MP0003300_gastrointestinal_ulcer2.41989665
16MP0003191_abnormal_cellular_cholesterol2.33911213
17MP0004510_myositis2.20327499
18MP0005025_abnormal_response_to2.17767157
19MP0003252_abnormal_bile_duct2.17391589
20MP0010329_abnormal_lipoprotein_level2.11412530
21* MP0001790_abnormal_immune_system2.10848088
22* MP0005387_immune_system_phenotype2.10848088
23MP0005671_abnormal_response_to2.09415387
24MP0006082_CNS_inflammation2.07605408
25MP0009764_decreased_sensitivity_to2.05971134
26MP0005000_abnormal_immune_tolerance1.95408330
27MP0002166_altered_tumor_susceptibility1.92921753
28MP0002419_abnormal_innate_immunity1.88107203
29MP0001853_heart_inflammation1.87898799
30MP0001800_abnormal_humoral_immune1.82961557
31MP0003806_abnormal_nucleotide_metabolis1.82659814
32MP0003195_calcinosis1.77671676
33MP0005083_abnormal_biliary_tract1.70836175
34MP0002006_tumorigenesis1.69727179
35MP0009333_abnormal_splenocyte_physiolog1.69254416
36MP0008469_abnormal_protein_level1.68463966
37* MP0002723_abnormal_immune_serum1.67705658
38MP0009278_abnormal_bone_marrow1.67585681
39MP0008004_abnormal_stomach_pH1.66374432
40MP0005332_abnormal_amino_acid1.64415199
41MP0000609_abnormal_liver_physiology1.62698316
42MP0002452_abnormal_antigen_presenting1.62090774
43MP0002332_abnormal_exercise_endurance1.61996243
44MP0001348_abnormal_lacrimal_gland1.52515027
45MP0005464_abnormal_platelet_physiology1.51040461
46MP0003186_abnormal_redox_activity1.48785418
47MP0004947_skin_inflammation1.42815027
48MP0001845_abnormal_inflammatory_respons1.40234407
49MP0005319_abnormal_enzyme/_coenzyme1.39605070
50MP0005166_decreased_susceptibility_to1.39197539
51* MP0001819_abnormal_immune_cell1.36781996
52MP0002118_abnormal_lipid_homeostasis1.36441435
53MP0006054_spinal_hemorrhage1.34928931
54MP0009763_increased_sensitivity_to1.33148830
55* MP0002420_abnormal_adaptive_immunity1.32959249
56MP0001666_abnormal_nutrient_absorption1.31035827
57MP0001533_abnormal_skeleton_physiology1.30784139
58MP0001346_abnormal_lacrimal_gland1.29823566
59MP0003172_abnormal_lysosome_physiology1.28949610
60MP0002163_abnormal_gland_morphology1.28644005
61MP0002876_abnormal_thyroid_physiology1.28105176
62MP0005584_abnormal_enzyme/coenzyme_acti1.27888419
63MP0005310_abnormal_salivary_gland1.26123350
64MP0010155_abnormal_intestine_physiology1.22184527
65MP0005167_abnormal_blood-brain_barrier1.21368975
66MP0004782_abnormal_surfactant_physiolog1.17452248
67MP0001764_abnormal_homeostasis1.14339203
68MP0004019_abnormal_vitamin_homeostasis1.12863058
69MP0005164_abnormal_response_to1.11275142
70MP0001873_stomach_inflammation1.07250848
71* MP0000716_abnormal_immune_system1.07159862
72MP0002933_joint_inflammation1.05381617
73MP0002405_respiratory_system_inflammati1.04572806
74MP0005165_increased_susceptibility_to1.00427681
75MP0009643_abnormal_urine_homeostasis0.99604614
76MP0003075_altered_response_to0.98469286
77MP0001663_abnormal_digestive_system0.97739103
78MP0005670_abnormal_white_adipose0.97689226
79MP0005379_endocrine/exocrine_gland_phen0.97227958
80MP0005390_skeleton_phenotype0.96857207
81MP0003303_peritoneal_inflammation0.96433965
82MP0005451_abnormal_body_composition0.95373882
83MP0002971_abnormal_brown_adipose0.94473495
84MP0000604_amyloidosis0.93497017
85MP0004130_abnormal_muscle_cell0.92670209
86* MP0002398_abnormal_bone_marrow0.92515335
87MP0003656_abnormal_erythrocyte_physiolo0.90978622
88MP0001542_abnormal_bone_strength0.90877044
89MP0003690_abnormal_glial_cell0.87544866
90MP0000598_abnormal_liver_morphology0.86757319
91MP0005058_abnormal_lysosome_morphology0.86001919
92MP0009697_abnormal_copulation0.85193235
93MP0003091_abnormal_cell_migration0.83404540
94* MP0002429_abnormal_blood_cell0.82914974
95MP0005397_hematopoietic_system_phenotyp0.82674550
96MP0001545_abnormal_hematopoietic_system0.82674550
97MP0000343_altered_response_to0.79629712
98MP0005023_abnormal_wound_healing0.79507102
99MP0009765_abnormal_xenobiotic_induced0.78726314
100MP0000689_abnormal_spleen_morphology0.78445605
101MP0003705_abnormal_hypodermis_morpholog0.77654712
102MP0005535_abnormal_body_temperature0.76316276
103MP0001501_abnormal_sleep_pattern0.74553881
104MP0001881_abnormal_mammary_gland0.74299498
105MP0009642_abnormal_blood_homeostasis0.74134915
106MP0008874_decreased_physiological_sensi0.73848798
107MP0003646_muscle_fatigue0.73529223
108MP0005647_abnormal_sex_gland0.73325797
109* MP0003763_abnormal_thymus_physiology0.73074152
110MP0002136_abnormal_kidney_physiology0.71341683
111MP0009115_abnormal_fat_cell0.71034280
112* MP0002722_abnormal_immune_system0.70524170
113MP0005334_abnormal_fat_pad0.70188893
114MP0005084_abnormal_gallbladder_morpholo0.69470593
115MP0004808_abnormal_hematopoietic_stem0.69012436
116MP0003448_altered_tumor_morphology0.69001870
117MP0002877_abnormal_melanocyte_morpholog0.68735454
118MP0002998_abnormal_bone_remodeling0.68261186
119MP0003453_abnormal_keratinocyte_physiol0.67412922
120MP0000858_altered_metastatic_potential0.67074774
121MP0003866_abnormal_defecation0.66572225
122MP0002277_abnormal_respiratory_mucosa0.66344632
123MP0000249_abnormal_blood_vessel0.65982016
124MP0004883_abnormal_blood_vessel0.64363326
125MP0000465_gastrointestinal_hemorrhage0.63199599
126MP0003950_abnormal_plasma_membrane0.62466718
127MP0003795_abnormal_bone_structure0.61383513
128MP0010352_gastrointestinal_tract_polyps0.61345344
129MP0002693_abnormal_pancreas_physiology0.60243762
130MP0005666_abnormal_adipose_tissue0.60046338
131MP0005266_abnormal_metabolism0.59497085
132MP0005381_digestive/alimentary_phenotyp0.57947790
133MP0001851_eye_inflammation0.56862973
134MP0003045_fibrosis0.54888966
135MP0000703_abnormal_thymus_morphology0.54255837

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.27275750
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.27275750
3Abnormality of glycolipid metabolism (HP:0010969)5.27275750
4Stomatitis (HP:0010280)4.44927555
5Prolonged partial thromboplastin time (HP:0003645)4.36065184
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26748592
7Autoimmune thrombocytopenia (HP:0001973)4.18111364
8Xanthomatosis (HP:0000991)3.98253913
9Recurrent gram-negative bacterial infections (HP:0005420)3.96994052
10Intrahepatic cholestasis (HP:0001406)3.96455783
11Deep venous thrombosis (HP:0002625)3.90490139
12Increased IgM level (HP:0003496)3.77080723
13Eczematoid dermatitis (HP:0000976)3.75634228
14Joint hemorrhage (HP:0005261)3.74158234
15Vacuolated lymphocytes (HP:0001922)3.69539094
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.65455856
17Recurrent bacterial skin infections (HP:0005406)3.61472328
18Complement deficiency (HP:0004431)3.49977047
19Dysostosis multiplex (HP:0000943)3.45682653
20Systemic lupus erythematosus (HP:0002725)3.44299555
21Hyperlipoproteinemia (HP:0010980)3.41677296
22Myocardial infarction (HP:0001658)3.38234669
23Recurrent abscess formation (HP:0002722)3.32913715
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.30353919
25Loss of speech (HP:0002371)3.29259825
26Abnormality of the common coagulation pathway (HP:0010990)3.25917065
27Gingival bleeding (HP:0000225)3.23224174
28Elevated erythrocyte sedimentation rate (HP:0003565)3.21802113
29Gangrene (HP:0100758)3.21301515
30Hypoglycemic coma (HP:0001325)3.17148050
31Hemoptysis (HP:0002105)3.14355909
32Hypobetalipoproteinemia (HP:0003563)3.11583058
33Myositis (HP:0100614)3.03005132
34T lymphocytopenia (HP:0005403)2.99769914
35Nuclear cataract (HP:0100018)2.97362850
36Orchitis (HP:0100796)2.96242928
37Increased cerebral lipofuscin (HP:0011813)2.96150723
38Abnormality of T cell number (HP:0011839)2.91769437
39Epidermoid cyst (HP:0200040)2.90753730
40Abnormality of fatty-acid metabolism (HP:0004359)2.89335589
41Hyperammonemia (HP:0001987)2.84922358
42Ketosis (HP:0001946)2.82845888
43Increased serum ferritin (HP:0003281)2.78841506
44Periodontitis (HP:0000704)2.78798739
45Disinhibition (HP:0000734)2.77135985
46Hypoalphalipoproteinemia (HP:0003233)2.76330717
47Parakeratosis (HP:0001036)2.74214388
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73273528
49Abnormality of polysaccharide metabolism (HP:0011012)2.73273528
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73273528
51Retrobulbar optic neuritis (HP:0100654)2.72224528
52Optic neuritis (HP:0100653)2.72224528
53Hypolipoproteinemia (HP:0010981)2.69884541
54Vasculitis (HP:0002633)2.68858425
55Hydroxyprolinuria (HP:0003080)2.67944134
56Abnormality of proline metabolism (HP:0010907)2.67944134
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67435108
58Chronic otitis media (HP:0000389)2.67225518
59Abnormality of complement system (HP:0005339)2.66071731
60Recurrent skin infections (HP:0001581)2.65767087
61Spontaneous abortion (HP:0005268)2.65461873
62Joint swelling (HP:0001386)2.65329263
63Tetraparesis (HP:0002273)2.60722217
64Autoimmune hemolytic anemia (HP:0001890)2.60335003
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60142531
66Mucopolysacchariduria (HP:0008155)2.60102869
67Urinary glycosaminoglycan excretion (HP:0003541)2.60102869
68Hypercholesterolemia (HP:0003124)2.59381490
69Hypergammaglobulinemia (HP:0010702)2.58679299
70Meningitis (HP:0001287)2.55591465
71Encephalitis (HP:0002383)2.55544211
72Mitral stenosis (HP:0001718)2.54661676
73IgA deficiency (HP:0002720)2.54563243
74Abnormality of the intrinsic pathway (HP:0010989)2.53446028
75Anorexia (HP:0002039)2.52968576
76Abnormality of macrophages (HP:0004311)2.52005634
77Hematochezia (HP:0002573)2.51905664
78Recurrent fungal infections (HP:0002841)2.51290433
79Progressive neurologic deterioration (HP:0002344)2.48857923
80Fat malabsorption (HP:0002630)2.48171995
81Hyperglycinuria (HP:0003108)2.46884052
82Thrombophlebitis (HP:0004418)2.46474810
83Abnormality of the pleura (HP:0002103)2.46395697
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.43406304
85Abnormality of pyrimidine metabolism (HP:0004353)2.39532809
86Gastrointestinal infarctions (HP:0005244)2.38758140
87Generalized aminoaciduria (HP:0002909)2.38731400
88Esophageal varix (HP:0002040)2.36775458
89Abnormality of methionine metabolism (HP:0010901)2.36723358
90Polyneuropathy (HP:0001271)2.35942526
91Arterial thrombosis (HP:0004420)2.35599440
92Increased IgE level (HP:0003212)2.35270126
93Abnormality of the pericardium (HP:0001697)2.35243251
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.34331125
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34298403
96Obstructive lung disease (HP:0006536)2.33946721
97Chronic obstructive pulmonary disease (HP:0006510)2.33946721
98Axonal loss (HP:0003447)2.31337005
99Mediastinal lymphadenopathy (HP:0100721)2.31333929
100Abnormality of iron homeostasis (HP:0011031)2.30144902
101Mutism (HP:0002300)2.28455859
102Conjugated hyperbilirubinemia (HP:0002908)2.28081443
103Abnormality of B cell number (HP:0010975)2.27805924
104Recurrent cutaneous fungal infections (HP:0011370)2.25777207
105Chronic mucocutaneous candidiasis (HP:0002728)2.25777207
106Recurrent bronchitis (HP:0002837)2.25582182
107Dicarboxylic aciduria (HP:0003215)2.22053034
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22053034
109Epistaxis (HP:0000421)2.21694675
110Abnormality of glycine metabolism (HP:0010895)2.21406050
111Abnormality of serine family amino acid metabolism (HP:0010894)2.21406050
112Vascular calcification (HP:0004934)2.21134052
113Basal ganglia calcification (HP:0002135)2.20364063
114Glomerulonephritis (HP:0000099)2.20232074
115Ketoacidosis (HP:0001993)2.20172810
116Hemorrhage of the eye (HP:0011885)2.19985345
117Recurrent viral infections (HP:0004429)2.19476354
118Malnutrition (HP:0004395)2.18554071
119Abnormality of nucleobase metabolism (HP:0010932)2.18228394
120Amyloidosis (HP:0011034)2.18003906
121Gingivitis (HP:0000230)2.17798946
122Hepatosplenomegaly (HP:0001433)2.16594071
123Leukocytosis (HP:0001974)2.16282955
124Urticaria (HP:0001025)2.16021861
125Gastrointestinal stroma tumor (HP:0100723)2.15420241
126Hyperbilirubinemia (HP:0002904)2.13482345
127Abnormal delayed hypersensitivity skin test (HP:0002963)2.11226412
128Petechiae (HP:0000967)2.10554306
129Pancreatitis (HP:0001733)2.10372581
130Hypertensive crisis (HP:0100735)2.10321021
131B lymphocytopenia (HP:0010976)2.10074518
132Nephritis (HP:0000123)2.09775661
133Thrombocytosis (HP:0001894)2.09431938
134Nasal polyposis (HP:0100582)2.09099871
135Abnormality of the nasal mucosa (HP:0000433)2.08805189
136Arthralgia (HP:0002829)2.07713465
137Abnormality of purine metabolism (HP:0004352)2.07576187
138Hypertriglyceridemia (HP:0002155)2.07006881
139Pulmonary embolism (HP:0002204)2.05931277
140Hypochromic anemia (HP:0001931)2.05702278
141Steatorrhea (HP:0002570)2.05658269
142Keratoconjunctivitis (HP:0001096)2.05571331
143Hyperglycinemia (HP:0002154)2.05530535
144Acne (HP:0001061)2.04602008
145Keratoconjunctivitis sicca (HP:0001097)2.04542043
146Interstitial pulmonary disease (HP:0006530)2.04269294
147Pulmonary infiltrates (HP:0002113)2.02350356
148Chronic diarrhea (HP:0002028)2.02215352
149Purpura (HP:0000979)2.02198574
150Nausea (HP:0002018)2.02166582
151Abnormality of the endocardium (HP:0004306)2.01144186
152Abnormality of T cells (HP:0002843)2.01031202
153Glomerulopathy (HP:0100820)2.00571674
154Menorrhagia (HP:0000132)2.00346847
155Renal cortical cysts (HP:0000803)2.00043496
156IgG deficiency (HP:0004315)1.99066483
157Episodic fever (HP:0001954)1.98407845
158Neurofibrillary tangles (HP:0002185)1.97447154
159Keratitis (HP:0000491)1.97228151
160Eosinophilia (HP:0001880)1.91760033
161Colitis (HP:0002583)1.90535980
162Granulocytopenia (HP:0001913)1.90492104
163Abnormality of transition element cation homeostasis (HP:0011030)1.90275761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.93879150
2TYK23.84360564
3TBK13.25068083
4GRK73.18671469
5FGFR43.03650641
6IKBKE2.88975907
7JAK32.87470911
8BCKDK2.73663486
9JAK12.70586555
10TAOK22.66285067
11IKBKB2.54325334
12ERN12.52392860
13PRPF4B2.28714392
14MAP3K132.28193326
15IRAK42.26379493
16IRAK32.23671136
17DDR22.13772409
18KIT1.99028736
19BLK1.97757634
20SIK11.86615654
21CHUK1.85758605
22FLT31.85305072
23TAOK31.80353701
24PIM21.78164536
25EPHA31.75940862
26MOS1.74872549
27INSRR1.69154006
28EPHB11.68570229
29TXK1.67777725
30MAP4K11.65122149
31NEK91.60100289
32FGFR31.46856625
33TAOK11.46179442
34ZAP701.42151651
35CDC42BPA1.33588567
36PIK3CG1.32035083
37PBK1.27886125
38FGR1.27366584
39JAK21.27137106
40IRAK11.20321539
41BTK1.17253002
42TEC1.11106676
43CSF1R1.09527852
44NLK1.08663896
45EIF2AK21.06658617
46MST1R1.05223542
47CLK11.03668054
48BMPR20.98942917
49RIPK40.97919593
50MAPK110.96285070
51CSK0.93672906
52PRKAA20.91817505
53STK100.90583349
54* SYK0.85702147
55MAP2K30.84218923
56HIPK20.82531791
57PIM10.82306532
58TGFBR20.79454290
59KDR0.77420243
60ABL20.76835628
61RPS6KA40.76256091
62TESK20.75826825
63TRPM70.75787746
64MAPKAPK30.74321418
65BCR0.73666307
66BMPR1B0.73198082
67MAP3K30.72259919
68LCK0.71430007
69HCK0.71246172
70PTK60.68890474
71NME20.67401191
72LYN0.67396377
73MAP2K60.67212132
74TESK10.66431001
75MYLK0.66237443
76MAP3K50.65989868
77TGFBR10.65594545
78MUSK0.63947969
79SIK30.63638415
80ERBB40.62534072
81RIPK10.61008882
82PIK3CA0.60765973
83FES0.59607069
84TIE10.58132815
85PKN20.57436421
86TRIB30.54804085
87STK40.51130517
88CAMK1D0.50245772
89MATK0.50076528
90PRKCQ0.48825759
91MAP3K120.48223737
92MST40.47938957
93LATS20.47491346
94NUAK10.47332046
95MARK30.47284973
96PRKCD0.45838160
97MAPK120.44130246
98ARAF0.43559515
99MAPK70.43103550
100MAP3K70.42495663
101ABL10.40622408
102MAPK40.40012088
103MAPKAPK20.39248582
104PDK10.38641531
105DAPK30.38619550
106CDK60.38436318
107TYRO30.38104972
108IRAK20.37535516
109PDGFRA0.36633135
110ERBB30.35450438
111PAK40.35189505
112PDPK10.34499775
113ITK0.34164527
114PKN10.33240176
115MAP3K10.32966976
116RPS6KA60.31881808
117TTN0.31857727
118IGF1R0.31403174
119ADRBK20.31356269
120ACVR1B0.30786657
121MAP3K110.28983186
122OBSCN0.28205965
123BMX0.28125751
124PRKACG0.28013902
125CDK40.27971206
126FRK0.27617048
127STK240.26719133
128INSR0.24113163
129PDGFRB0.23390353
130DAPK20.22392659
131TNK20.21958041
132RPS6KC10.20149504
133RPS6KL10.20149504
134DAPK10.19384982
135PRKG20.19045839

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.65263533
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.47338177
3Staphylococcus aureus infection_Homo sapiens_hsa051502.56607017
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40171377
5Complement and coagulation cascades_Homo sapiens_hsa046102.31619151
6Allograft rejection_Homo sapiens_hsa053302.28997648
7Tryptophan metabolism_Homo sapiens_hsa003802.27416802
8Fatty acid degradation_Homo sapiens_hsa000712.25058497
9Arginine biosynthesis_Homo sapiens_hsa002202.20190002
10Other glycan degradation_Homo sapiens_hsa005112.17718136
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13727189
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01831341
13Caffeine metabolism_Homo sapiens_hsa002321.91416270
14Graft-versus-host disease_Homo sapiens_hsa053321.91225420
15Peroxisome_Homo sapiens_hsa041461.89591278
16Nitrogen metabolism_Homo sapiens_hsa009101.80360000
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78040497
18PPAR signaling pathway_Homo sapiens_hsa033201.71534756
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64530851
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61506348
21Lysosome_Homo sapiens_hsa041421.59173513
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57986136
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56704317
24* Intestinal immune network for IgA production_Homo sapiens_hsa046721.56072701
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.55738786
26Propanoate metabolism_Homo sapiens_hsa006401.55736528
27Salmonella infection_Homo sapiens_hsa051321.54977262
28Leishmaniasis_Homo sapiens_hsa051401.51143837
29Fatty acid metabolism_Homo sapiens_hsa012121.51005605
30Histidine metabolism_Homo sapiens_hsa003401.48283423
31Phenylalanine metabolism_Homo sapiens_hsa003601.47115159
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46397354
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45239093
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.44799973
35Measles_Homo sapiens_hsa051621.39515627
36Chemical carcinogenesis_Homo sapiens_hsa052041.38204396
37beta-Alanine metabolism_Homo sapiens_hsa004101.37685356
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.30494392
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28318986
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28070382
41ABC transporters_Homo sapiens_hsa020101.26229385
42Autoimmune thyroid disease_Homo sapiens_hsa053201.25494879
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21837687
44Retinol metabolism_Homo sapiens_hsa008301.21045920
45Starch and sucrose metabolism_Homo sapiens_hsa005001.17528574
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16025948
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.15200593
48Influenza A_Homo sapiens_hsa051641.13841013
49B cell receptor signaling pathway_Homo sapiens_hsa046621.12297397
50Legionellosis_Homo sapiens_hsa051341.09337682
51Hepatitis B_Homo sapiens_hsa051611.07979190
52T cell receptor signaling pathway_Homo sapiens_hsa046601.06609012
53Tyrosine metabolism_Homo sapiens_hsa003501.05448801
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02832336
55TNF signaling pathway_Homo sapiens_hsa046681.02793060
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02542149
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02162748
58Type I diabetes mellitus_Homo sapiens_hsa049401.01187966
59Shigellosis_Homo sapiens_hsa051311.01050223
60Butanoate metabolism_Homo sapiens_hsa006501.00361294
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96515768
62Herpes simplex infection_Homo sapiens_hsa051680.94597707
63Pertussis_Homo sapiens_hsa051330.94152587
64Folate biosynthesis_Homo sapiens_hsa007900.94141421
65Phagosome_Homo sapiens_hsa041450.91082065
66Osteoclast differentiation_Homo sapiens_hsa043800.90972297
67Selenocompound metabolism_Homo sapiens_hsa004500.90308335
68Primary immunodeficiency_Homo sapiens_hsa053400.88958930
69* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88595144
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88506209
71African trypanosomiasis_Homo sapiens_hsa051430.85805287
72Malaria_Homo sapiens_hsa051440.85741021
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85032407
74Asthma_Homo sapiens_hsa053100.84786322
75Sulfur metabolism_Homo sapiens_hsa009200.84722786
76* Jak-STAT signaling pathway_Homo sapiens_hsa046300.84149320
77Fatty acid biosynthesis_Homo sapiens_hsa000610.83472191
78Toxoplasmosis_Homo sapiens_hsa051450.83118848
79Epstein-Barr virus infection_Homo sapiens_hsa051690.82876938
80Amoebiasis_Homo sapiens_hsa051460.82809744
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80846151
82Acute myeloid leukemia_Homo sapiens_hsa052210.80588635
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79295551
84Fatty acid elongation_Homo sapiens_hsa000620.78806537
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.77849634
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77782549
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77029393
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76665860
89Vitamin digestion and absorption_Homo sapiens_hsa049770.70393854
90Sulfur relay system_Homo sapiens_hsa041220.69024825
91Bladder cancer_Homo sapiens_hsa052190.68145508
92Bile secretion_Homo sapiens_hsa049760.67715801
93Carbon metabolism_Homo sapiens_hsa012000.64881888
94Pyruvate metabolism_Homo sapiens_hsa006200.64481784
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64036979
96Antigen processing and presentation_Homo sapiens_hsa046120.63361467
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63077526
98Hepatitis C_Homo sapiens_hsa051600.62360595
99Rheumatoid arthritis_Homo sapiens_hsa053230.62152573
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61149432
101Prolactin signaling pathway_Homo sapiens_hsa049170.61132319
102Fat digestion and absorption_Homo sapiens_hsa049750.61113812
103Tuberculosis_Homo sapiens_hsa051520.60549654
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.59922371
105Apoptosis_Homo sapiens_hsa042100.58230972
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52588933
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52263111
108Viral myocarditis_Homo sapiens_hsa054160.51883527
109Insulin resistance_Homo sapiens_hsa049310.49980381
110Arginine and proline metabolism_Homo sapiens_hsa003300.49800619
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49575788
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.49463797
113* HTLV-I infection_Homo sapiens_hsa051660.49462112
114VEGF signaling pathway_Homo sapiens_hsa043700.48128577
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.47449106
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46901360
117One carbon pool by folate_Homo sapiens_hsa006700.45241342
118Sphingolipid metabolism_Homo sapiens_hsa006000.44474008
119Systemic lupus erythematosus_Homo sapiens_hsa053220.44109015
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42752736
121Glycerolipid metabolism_Homo sapiens_hsa005610.42244612
122Pentose phosphate pathway_Homo sapiens_hsa000300.42188186
123Hematopoietic cell lineage_Homo sapiens_hsa046400.39459919
124Biosynthesis of amino acids_Homo sapiens_hsa012300.39446404
125Galactose metabolism_Homo sapiens_hsa000520.38837509
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38343668
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38288375
128Chemokine signaling pathway_Homo sapiens_hsa040620.37160352
129Lysine degradation_Homo sapiens_hsa003100.37117204
130Prion diseases_Homo sapiens_hsa050200.33612242
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.32826498
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.32808702
133Fructose and mannose metabolism_Homo sapiens_hsa000510.31841879
134Type II diabetes mellitus_Homo sapiens_hsa049300.30254219
135Viral carcinogenesis_Homo sapiens_hsa052030.29766400
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26406447
137Collecting duct acid secretion_Homo sapiens_hsa049660.26005830
138Mineral absorption_Homo sapiens_hsa049780.25529137
139HIF-1 signaling pathway_Homo sapiens_hsa040660.25282322
140Pancreatic cancer_Homo sapiens_hsa052120.22916237
141Chronic myeloid leukemia_Homo sapiens_hsa052200.21772185
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21037621
143Proteasome_Homo sapiens_hsa030500.18938437
144Platelet activation_Homo sapiens_hsa046110.16459909
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.14149641
146Endocytosis_Homo sapiens_hsa041440.13291369
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10896106
148Vibrio cholerae infection_Homo sapiens_hsa051100.10101211
149Renin-angiotensin system_Homo sapiens_hsa046140.09060222
150Small cell lung cancer_Homo sapiens_hsa052220.09014104
151FoxO signaling pathway_Homo sapiens_hsa040680.08214414

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