IL16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.40664963
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.78595080
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.78595080
4antigen processing and presentation of endogenous antigen (GO:0019883)6.34916471
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.96170022
6regulation of gamma-delta T cell differentiation (GO:0045586)5.83154409
7regulation of B cell receptor signaling pathway (GO:0050855)5.51185131
8regulation of gamma-delta T cell activation (GO:0046643)5.35573667
9positive thymic T cell selection (GO:0045059)5.19765130
10negative T cell selection (GO:0043383)5.09870634
11B cell receptor signaling pathway (GO:0050853)4.97162270
12negative thymic T cell selection (GO:0045060)4.93298940
13mast cell activation (GO:0045576)4.72559498
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64975136
15negative regulation of cell killing (GO:0031342)4.64975136
16regulation of B cell differentiation (GO:0045577)4.63855628
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.61123688
18leukocyte aggregation (GO:0070486)4.58117971
19positive regulation of B cell differentiation (GO:0045579)4.56706086
20positive T cell selection (GO:0043368)4.56190017
21T cell migration (GO:0072678)4.51027618
22response to interleukin-15 (GO:0070672)4.49921184
23positive regulation by symbiont of host defense response (GO:0052509)4.47541573
24modulation by symbiont of host defense response (GO:0052031)4.47541573
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47541573
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47541573
27positive regulation by organism of defense response of other organism involved in symbiotic interact4.47541573
28modulation by symbiont of host immune response (GO:0052553)4.47541573
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.31877246
30cellular response to interleukin-15 (GO:0071350)4.29720847
31detection of other organism (GO:0098543)4.28747336
32detection of bacterium (GO:0016045)4.27423510
33thymic T cell selection (GO:0045061)4.26271102
34T cell selection (GO:0045058)4.26136292
35mast cell activation involved in immune response (GO:0002279)4.14027490
36mast cell degranulation (GO:0043303)4.14027490
37interferon-gamma production (GO:0032609)4.13514934
38negative regulation of phagocytosis (GO:0050765)4.12990519
39negative regulation of T cell mediated immunity (GO:0002710)4.09699640
40antigen receptor-mediated signaling pathway (GO:0050851)4.07503982
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.06529373
42cellular extravasation (GO:0045123)4.04802125
43ribosomal small subunit assembly (GO:0000028)4.03650068
44neutrophil activation involved in immune response (GO:0002283)4.01881159
45antigen processing and presentation via MHC class Ib (GO:0002475)3.97690664
46T cell homeostasis (GO:0043029)3.89490136
47negative regulation of leukocyte mediated immunity (GO:0002704)3.86248205
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.84811159
49T cell receptor signaling pathway (GO:0050852)3.81270929
50macrophage activation involved in immune response (GO:0002281)3.79248403
51regulation of T cell receptor signaling pathway (GO:0050856)3.69839182
52regulation of T cell mediated cytotoxicity (GO:0001914)3.63819418
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.61412711
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57242149
55regulation of tolerance induction (GO:0002643)3.54711654
56negative regulation of interleukin-12 production (GO:0032695)3.53451301
57positive regulation of T cell mediated cytotoxicity (GO:0001916)3.52035681
58T cell costimulation (GO:0031295)3.51211127
59lymphocyte homeostasis (GO:0002260)3.50265376
60neutrophil activation (GO:0042119)3.48111227
61lymphocyte costimulation (GO:0031294)3.46247426
62detection of external biotic stimulus (GO:0098581)3.41929478
63NIK/NF-kappaB signaling (GO:0038061)3.40968325
64cellular response to zinc ion (GO:0071294)3.38730925
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38381205
66regulation of interferon-beta biosynthetic process (GO:0045357)3.36069098
67regulation of regulatory T cell differentiation (GO:0045589)3.35226337
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31803572
69hepatocyte apoptotic process (GO:0097284)3.31726374
70megakaryocyte development (GO:0035855)3.30241855
71myeloid cell activation involved in immune response (GO:0002275)3.29753016
72regulation of alpha-beta T cell proliferation (GO:0046640)3.29726969
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28579994
74mature B cell differentiation (GO:0002335)3.28574400
75regulation of T cell tolerance induction (GO:0002664)3.26885101
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26449384
77immunoglobulin mediated immune response (GO:0016064)3.24674861
78leukocyte homeostasis (GO:0001776)3.23395230
79response to type I interferon (GO:0034340)3.22663972
80tolerance induction (GO:0002507)3.21307980
81response to peptidoglycan (GO:0032494)3.21011085
82positive regulation of granulocyte differentiation (GO:0030854)3.20875910
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.19973723
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19735110
85response to host immune response (GO:0052572)3.19735110
86lymph node development (GO:0048535)3.19447490
87B cell mediated immunity (GO:0019724)3.17342349
88granulocyte activation (GO:0036230)3.16843939
89cellular response to type I interferon (GO:0071357)3.16176995
90type I interferon signaling pathway (GO:0060337)3.16176995
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15998299
92negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.14814916
93immune response-activating cell surface receptor signaling pathway (GO:0002429)3.13439572
94myeloid dendritic cell activation (GO:0001773)3.12083582
95response to muramyl dipeptide (GO:0032495)3.10993665
96defense response to protozoan (GO:0042832)3.07432575
97positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.07115050
98germinal center formation (GO:0002467)3.06274452
99negative regulation of innate immune response (GO:0045824)3.06149971
100regulation of isotype switching to IgG isotypes (GO:0048302)3.05176391
101positive regulation of interleukin-2 production (GO:0032743)3.04383749
102response to protozoan (GO:0001562)3.02687532
103microglial cell activation (GO:0001774)3.01559900
104respiratory burst (GO:0045730)3.01325547
105regulation of antigen processing and presentation (GO:0002577)3.01309190
106interferon-gamma-mediated signaling pathway (GO:0060333)3.01184645
107negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01046249
108regulation of cell killing (GO:0031341)3.00471604
109detection of biotic stimulus (GO:0009595)2.97508501
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96545964
111response to host (GO:0075136)2.96545964
112response to host defenses (GO:0052200)2.96545964
113mature B cell differentiation involved in immune response (GO:0002313)2.95739297
114negative regulation of T-helper cell differentiation (GO:0045623)2.95666526
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95666526
116negative regulation of erythrocyte differentiation (GO:0045647)2.95065018
117regulation of mast cell degranulation (GO:0043304)2.95029904
118V(D)J recombination (GO:0033151)2.92749005
119natural killer cell activation (GO:0030101)2.92723136
120T cell proliferation (GO:0042098)2.91492776
121leukocyte cell-cell adhesion (GO:0007159)2.91038524
122T cell differentiation (GO:0030217)2.89597978
123regulation of response to interferon-gamma (GO:0060330)2.89118782
124B cell homeostasis (GO:0001782)2.88696067
125positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88626376
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88535753
127natural killer cell differentiation (GO:0001779)2.88401246
128positive regulation of tolerance induction (GO:0002645)2.87496485
129regulation of natural killer cell mediated immunity (GO:0002715)2.82966712
130regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82966712
131leukocyte degranulation (GO:0043299)2.80354849
132regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.80143231
133activated T cell proliferation (GO:0050798)2.78455728
134negative regulation of T cell receptor signaling pathway (GO:0050860)2.78132693
135lymphocyte proliferation (GO:0046651)2.77366071
136B cell proliferation (GO:0042100)2.77111805
137mononuclear cell proliferation (GO:0032943)2.75336812
138regulation of interleukin-2 biosynthetic process (GO:0045076)2.74801918
139positive regulation of lamellipodium assembly (GO:0010592)2.74104077
140viral transcription (GO:0019083)2.73071193
141Peyers patch development (GO:0048541)2.72821133
142mucosal-associated lymphoid tissue development (GO:0048537)2.72821133
143regulation of granulocyte differentiation (GO:0030852)2.71752089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.42230474
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.82288732
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.69275649
4E2F7_22180533_ChIP-Seq_HELA_Human4.13495706
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.06305528
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.73393218
7MYC_22102868_ChIP-Seq_BL_Human3.56998929
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.42028210
9SCL_19346495_ChIP-Seq_HPC-7_Human3.35513478
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.08487556
11RUNX_20019798_ChIP-Seq_JUKART_Human3.08101021
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98105974
13VDR_21846776_ChIP-Seq_THP-1_Human2.89441056
14* MYB_26560356_Chip-Seq_TH2_Human2.84709428
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83261121
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.80762364
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76270053
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74001066
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73867326
20* MAF_26560356_Chip-Seq_TH1_Human2.61246179
21* MYB_26560356_Chip-Seq_TH1_Human2.50965029
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.44125585
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.38960389
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38830245
25* UTX_26944678_Chip-Seq_JUKART_Human2.38812486
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38145448
27* SPI1_23547873_ChIP-Seq_NB4_Human2.35329209
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.26814997
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25170945
30VDR_24763502_ChIP-Seq_THP-1_Human2.14955638
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14686523
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.14563247
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.09073686
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08048166
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07029758
36BP1_19119308_ChIP-ChIP_Hs578T_Human2.05201844
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00603025
38TCF7_22412390_ChIP-Seq_EML_Mouse1.96718050
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86990437
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86428612
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81976978
42CIITA_25753668_ChIP-Seq_RAJI_Human1.76480362
43SPI1_23127762_ChIP-Seq_K562_Human1.75259836
44* GATA3_27048872_Chip-Seq_THYMUS_Human1.74162448
45GATA1_22025678_ChIP-Seq_K562_Human1.73479189
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.70297049
47* MAF_26560356_Chip-Seq_TH2_Human1.65904695
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64107392
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63625487
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63567547
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56357919
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53804328
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53193463
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52347594
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49035140
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48610377
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.45567359
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44762199
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41678800
60VDR_24787735_ChIP-Seq_THP-1_Human1.40798556
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38061608
62KDM2B_26808549_Chip-Seq_DND41_Human1.36439470
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33707434
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33218125
65* FOXP3_21729870_ChIP-Seq_TREG_Human1.32343152
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31812417
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30860323
68PU_27001747_Chip-Seq_BMDM_Mouse1.28502149
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25141241
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24664765
71* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23077485
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22607783
73VDR_23849224_ChIP-Seq_CD4+_Human1.22001312
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.16824801
75BCL6_27268052_Chip-Seq_Bcells_Human1.14940695
76* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14891522
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14375040
78* GATA3_26560356_Chip-Seq_TH2_Human1.14019318
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09934809
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08886141
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07143362
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06764841
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.03822586
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02564378
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02285825
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01538839
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00903129
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00336811
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00001390
90BCOR_27268052_Chip-Seq_Bcells_Human0.99861734
91* LXR_22292898_ChIP-Seq_THP-1_Human0.98531970
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97277321
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96388347
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95860601
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91071398
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89298147
97* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88996574
98ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88673407
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84248281
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84245879
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83938245
102* GATA2_19941826_ChIP-Seq_K562_Human0.82892927
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.82554200
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81626133
105SPI1_20517297_ChIP-Seq_HL60_Human0.81213513
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81026832
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80171257
108RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79797064
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79433139
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78199392
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77488026
112E2F1_21310950_ChIP-Seq_MCF-7_Human0.75806340
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.74684100
114GATA1_19941826_ChIP-Seq_K562_Human0.74627738
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.73263944
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71842097
117NCOR1_26117541_ChIP-Seq_K562_Human0.70438984
118* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69629946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.34732600
2MP0003763_abnormal_thymus_physiology3.98090834
3MP0005671_abnormal_response_to3.89980256
4MP0000685_abnormal_immune_system3.60889922
5MP0001800_abnormal_humoral_immune3.52486416
6MP0002396_abnormal_hematopoietic_system3.52441761
7MP0001790_abnormal_immune_system3.08237657
8MP0005387_immune_system_phenotype3.08237657
9MP0002452_abnormal_antigen_presenting2.92271135
10MP0009785_altered_susceptibility_to2.91414713
11MP0002398_abnormal_bone_marrow2.90391360
12* MP0002420_abnormal_adaptive_immunity2.89929249
13MP0002166_altered_tumor_susceptibility2.86231680
14* MP0001819_abnormal_immune_cell2.85257068
15MP0002723_abnormal_immune_serum2.83612317
16MP0005000_abnormal_immune_tolerance2.83570029
17MP0005025_abnormal_response_to2.63642338
18MP0003436_decreased_susceptibility_to2.58682405
19MP0000716_abnormal_immune_system2.55040346
20MP0000689_abnormal_spleen_morphology2.42175161
21MP0002722_abnormal_immune_system2.33799751
22MP0000703_abnormal_thymus_morphology2.30204497
23MP0002419_abnormal_innate_immunity2.26185794
24MP0005464_abnormal_platelet_physiology2.25791840
25MP0004808_abnormal_hematopoietic_stem2.24800643
26MP0002148_abnormal_hypersensitivity_rea2.21545697
27MP0002006_tumorigenesis2.16976154
28MP0009333_abnormal_splenocyte_physiolog2.15444744
29MP0002429_abnormal_blood_cell2.14287300
30MP0003303_peritoneal_inflammation2.13747168
31MP0002405_respiratory_system_inflammati2.10462319
32MP0001873_stomach_inflammation2.00449172
33MP0010155_abnormal_intestine_physiology1.99245626
34MP0005397_hematopoietic_system_phenotyp1.85331523
35MP0001545_abnormal_hematopoietic_system1.85331523
36MP0003724_increased_susceptibility_to1.84627850
37MP0003866_abnormal_defecation1.82231653
38MP0000465_gastrointestinal_hemorrhage1.76291397
39MP0005174_abnormal_tail_pigmentation1.70101617
40MP0006082_CNS_inflammation1.68993604
41MP0001845_abnormal_inflammatory_respons1.68721586
42MP0002933_joint_inflammation1.63918242
43MP0001853_heart_inflammation1.62666017
44MP0004947_skin_inflammation1.62531696
45MP0003300_gastrointestinal_ulcer1.60725463
46MP0005075_abnormal_melanosome_morpholog1.58469109
47MP0009278_abnormal_bone_marrow1.55201073
48MP0008260_abnormal_autophagy1.50011236
49MP0000490_abnormal_crypts_of1.38116246
50MP0003183_abnormal_peptide_metabolism1.33549699
51MP0004510_myositis1.26710349
52MP0002095_abnormal_skin_pigmentation1.16277161
53MP0005451_abnormal_body_composition1.15395785
54MP0010094_abnormal_chromosome_stability1.15392774
55MP0000858_altered_metastatic_potential1.13660504
56MP0002019_abnormal_tumor_incidence1.13390568
57MP0008469_abnormal_protein_level1.13018915
58MP0001533_abnormal_skeleton_physiology1.11820488
59MP0008057_abnormal_DNA_replication1.10407623
60MP0008007_abnormal_cellular_replicative1.03986477
61MP0002277_abnormal_respiratory_mucosa1.02183775
62MP0002138_abnormal_hepatobiliary_system1.01136606
63MP0005310_abnormal_salivary_gland0.99567376
64MP0001986_abnormal_taste_sensitivity0.98560088
65MP0004883_abnormal_blood_vessel0.96524886
66MP0003077_abnormal_cell_cycle0.96005345
67MP0001851_eye_inflammation0.90642160
68MP0000015_abnormal_ear_pigmentation0.87936626
69MP0006054_spinal_hemorrhage0.86074327
70MP0005166_decreased_susceptibility_to0.84991500
71MP0002132_abnormal_respiratory_system0.83404521
72MP0008058_abnormal_DNA_repair0.80527693
73MP0003075_altered_response_to0.79613042
74MP0003191_abnormal_cellular_cholesterol0.76256482
75MP0003045_fibrosis0.74188320
76MP0003448_altered_tumor_morphology0.73984639
77MP0009763_increased_sensitivity_to0.73710917
78MP0003690_abnormal_glial_cell0.73402150
79MP0010352_gastrointestinal_tract_polyps0.72903914
80MP0000604_amyloidosis0.71122602
81MP0003693_abnormal_embryo_hatching0.70510123
82MP0003111_abnormal_nucleus_morphology0.70109777
83MP0004381_abnormal_hair_follicle0.69633693
84MP0005058_abnormal_lysosome_morphology0.69034498
85MP0004147_increased_porphyrin_level0.68997271
86MP0003172_abnormal_lysosome_physiology0.68609566
87MP0005390_skeleton_phenotype0.67948740
88MP0003943_abnormal_hepatobiliary_system0.67812877
89MP0009764_decreased_sensitivity_to0.67651238
90MP0002998_abnormal_bone_remodeling0.65404177
91MP0005164_abnormal_response_to0.65253244
92MP0003828_pulmonary_edema0.64288971
93MP0009765_abnormal_xenobiotic_induced0.64162727
94MP0001663_abnormal_digestive_system0.63792559
95MP0000343_altered_response_to0.61410101
96MP0002009_preneoplasia0.60410330
97MP0000313_abnormal_cell_death0.59622962
98MP0004130_abnormal_muscle_cell0.57920624
99MP0005409_darkened_coat_color0.57500823
100MP0008874_decreased_physiological_sensi0.56912189
101MP0000477_abnormal_intestine_morphology0.56763482
102MP0005023_abnormal_wound_healing0.55472120
103MP0008004_abnormal_stomach_pH0.54928973
104MP0008569_lethality_at_weaning0.54055990
105MP0003656_abnormal_erythrocyte_physiolo0.54027503
106MP0002693_abnormal_pancreas_physiology0.53171788
107MP0001348_abnormal_lacrimal_gland0.51929876
108MP0010307_abnormal_tumor_latency0.51734348
109MP0003795_abnormal_bone_structure0.50599094
110MP0003252_abnormal_bile_duct0.49602518
111MP0008961_abnormal_basal_metabolism0.48420292
112MP0003279_aneurysm0.48007818
113MP0000249_abnormal_blood_vessel0.47709061
114MP0002928_abnormal_bile_duct0.46682781
115MP0002083_premature_death0.45613121
116MP0008873_increased_physiological_sensi0.44818053
117MP0005381_digestive/alimentary_phenotyp0.44467339
118MP0002136_abnormal_kidney_physiology0.44273627
119MP0000609_abnormal_liver_physiology0.43353845
120MP0001765_abnormal_ion_homeostasis0.39230031
121MP0003091_abnormal_cell_migration0.39094163
122MP0002133_abnormal_respiratory_system0.38726666

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.43359131
2Recurrent bronchitis (HP:0002837)5.16996415
3IgM deficiency (HP:0002850)4.94309802
4Panhypogammaglobulinemia (HP:0003139)4.91873355
5Chronic otitis media (HP:0000389)4.84014539
6T lymphocytopenia (HP:0005403)4.81456518
7Recurrent viral infections (HP:0004429)4.71703312
8Abnormality of T cell number (HP:0011839)4.62851236
9Elevated erythrocyte sedimentation rate (HP:0003565)4.45592943
10Recurrent fungal infections (HP:0002841)4.38908267
11B lymphocytopenia (HP:0010976)4.32345036
12Abnormality of B cell number (HP:0010975)4.32345036
13Thyroiditis (HP:0100646)4.30050190
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.22975890
15Meningitis (HP:0001287)4.09584231
16Abnormality of T cells (HP:0002843)4.08867400
17Recurrent abscess formation (HP:0002722)4.02965038
18Gastrointestinal infarctions (HP:0005244)3.93975972
19Chronic mucocutaneous candidiasis (HP:0002728)3.93805534
20Recurrent cutaneous fungal infections (HP:0011370)3.93805534
21Cellulitis (HP:0100658)3.90216904
22Thrombocytosis (HP:0001894)3.81303494
23Lymphopenia (HP:0001888)3.80714304
24Severe combined immunodeficiency (HP:0004430)3.75926405
25Gastrointestinal stroma tumor (HP:0100723)3.73828611
26IgG deficiency (HP:0004315)3.72945471
27Inflammation of the large intestine (HP:0002037)3.69181951
28Gastrointestinal inflammation (HP:0004386)3.68945837
29Myositis (HP:0100614)3.68249854
30Abnormality of cells of the lymphoid lineage (HP:0012140)3.65758343
31Colitis (HP:0002583)3.61132096
32Eczematoid dermatitis (HP:0000976)3.52431930
33Nasal polyposis (HP:0100582)3.51745967
34Combined immunodeficiency (HP:0005387)3.47019251
35Recurrent sinusitis (HP:0011108)3.45362261
36Increased IgM level (HP:0003496)3.45186499
37Papilloma (HP:0012740)3.44614427
38Verrucae (HP:0200043)3.44614427
39Abnormality of the fingertips (HP:0001211)3.35682697
40Recurrent bacterial skin infections (HP:0005406)3.34837960
41Abnormality of T cell physiology (HP:0011840)3.31023133
42Chronic sinusitis (HP:0011109)3.23808074
43Chronic diarrhea (HP:0002028)3.21771020
44Abnormality of eosinophils (HP:0001879)3.12695096
45Spontaneous hematomas (HP:0007420)3.10821187
46Keratoconjunctivitis (HP:0001096)3.10818504
47Abnormality of the nasal mucosa (HP:0000433)3.09779058
48Hypoplasia of the thymus (HP:0000778)3.09320803
49Vasculitis (HP:0002633)3.08794705
50Recurrent skin infections (HP:0001581)3.07626538
51Urticaria (HP:0001025)3.06282454
52Eosinophilia (HP:0001880)3.04822170
53Gingivitis (HP:0000230)2.94496609
54Mediastinal lymphadenopathy (HP:0100721)2.92623167
55Bronchitis (HP:0012387)2.88362224
56Stomatitis (HP:0010280)2.83935245
57Granulocytopenia (HP:0001913)2.81138153
58Prolonged bleeding time (HP:0003010)2.76742127
59Hypochromic anemia (HP:0001931)2.75791360
60Obstructive lung disease (HP:0006536)2.73203943
61Chronic obstructive pulmonary disease (HP:0006510)2.73203943
62Lymphoma (HP:0002665)2.72292335
63Encephalitis (HP:0002383)2.69707316
64Leukocytosis (HP:0001974)2.68085496
65Pulmonary embolism (HP:0002204)2.65922025
66Gingival bleeding (HP:0000225)2.64795672
67IgA deficiency (HP:0002720)2.62867303
68Abnormality of the prostate (HP:0008775)2.60858303
69Emphysema (HP:0002097)2.56877472
70Pustule (HP:0200039)2.55111254
71Autoimmune hemolytic anemia (HP:0001890)2.51589146
72Hypochromic microcytic anemia (HP:0004840)2.50723908
73Osteomyelitis (HP:0002754)2.49892104
74Petechiae (HP:0000967)2.48783960
75Autoimmune thrombocytopenia (HP:0001973)2.45738677
76Papilledema (HP:0001085)2.45407258
77Epistaxis (HP:0000421)2.36648162
78Sepsis (HP:0100806)2.36396968
79Abnormality of the pleura (HP:0002103)2.34717004
80Basal cell carcinoma (HP:0002671)2.34249829
81Anorexia (HP:0002039)2.33891794
82Recurrent pneumonia (HP:0006532)2.32527052
83Recurrent lower respiratory tract infections (HP:0002783)2.29743565
84Gangrene (HP:0100758)2.29143953
85Joint swelling (HP:0001386)2.27591869
86Hemoptysis (HP:0002105)2.27235046
87Episodic fever (HP:0001954)2.25505029
88Skin rash (HP:0000988)2.21567932
89Acute hepatic failure (HP:0006554)2.20723492
90Recurrent otitis media (HP:0000403)2.19407353
91Increased IgE level (HP:0003212)2.16725164
92Optic neuritis (HP:0100653)2.15742240
93Retrobulbar optic neuritis (HP:0100654)2.15742240
94Microcytic anemia (HP:0001935)2.12395260
95Arterial thrombosis (HP:0004420)2.12336220
96Periodontitis (HP:0000704)2.10552673
97Amaurosis fugax (HP:0100576)2.08905134
98Chest pain (HP:0100749)2.08413956
99Glomerulopathy (HP:0100820)2.07538329
100Orchitis (HP:0100796)2.06645316
101Stomach cancer (HP:0012126)2.05972217
102Cheilitis (HP:0100825)2.04711099
103Restrictive lung disease (HP:0002091)2.04389313
104Skin ulcer (HP:0200042)2.01117302
105Neutropenia (HP:0001875)2.00831436
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00441906
107Pulmonary infiltrates (HP:0002113)2.00433515
108Viral hepatitis (HP:0006562)1.99386105
109Acute lymphatic leukemia (HP:0006721)1.98448654
110Purpura (HP:0000979)1.97355140
111Recurrent gram-negative bacterial infections (HP:0005420)1.96861839
112Slow saccadic eye movements (HP:0000514)1.96647189
113Hypoproteinemia (HP:0003075)1.95740555
114Reticulocytopenia (HP:0001896)1.95499959
115Hypergammaglobulinemia (HP:0010702)1.93857202
116Leukopenia (HP:0001882)1.93304743
117Acute myeloid leukemia (HP:0004808)1.93031849
118Arthralgia (HP:0002829)1.92508538
119Interstitial pulmonary disease (HP:0006530)1.91015728
120Abnormality of macrophages (HP:0004311)1.89987064
121Aplasia/Hypoplasia of the thymus (HP:0010515)1.89211395
122Keratoconjunctivitis sicca (HP:0001097)1.85076882
123Poikiloderma (HP:0001029)1.84940187
124Hematochezia (HP:0002573)1.82618092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.20928729
2TXK3.36109901
3KIT2.90169038
4MAP3K102.56346986
5PRPF4B2.46589760
6BTK2.40854914
7EEF2K2.38526063
8ZAP702.34660923
9GRK62.31758830
10TYK22.29967044
11TEC2.29162967
12ITK2.27486452
13JAK32.19599047
14CSF1R2.19289365
15BLK2.11543973
16STK102.10852346
17FLT32.08048408
18IKBKE2.06767185
19SYK2.01902657
20MAP3K141.88790880
21IRAK41.68548265
22LCK1.66662302
23FGFR31.66468620
24TBK11.64147510
25FES1.62517008
26PIK3CG1.58569067
27CLK11.58449109
28NLK1.57722822
29JAK11.54893805
30HCK1.51071980
31RIPK41.47364797
32TGFBR21.47241257
33MAP3K131.43986752
34FGFR41.43784069
35SIK21.41853139
36CSK1.32642155
37MAP3K111.32205631
38MAP2K31.29180778
39LYN1.27367154
40SIK31.25802173
41ERN11.14778379
42IKBKB1.13964511
43FGR1.10957825
44MARK31.10379502
45LRRK21.09423421
46NME21.07416609
47MAP3K31.07311943
48PKN21.05913036
49PIM11.05135615
50BMPR21.04188664
51TAOK11.01486896
52KDR0.95860920
53CAMKK10.91337227
54TNK20.89272191
55MAP3K10.89140028
56CAMKK20.83039949
57RPS6KA40.81545023
58PRKCH0.80645896
59TNIK0.80017685
60MATK0.73105721
61TGFBR10.71993193
62PRKCQ0.70248385
63RPS6KB20.69906722
64MAPK110.69760247
65YES10.69174235
66TAOK30.69104272
67STK40.66983007
68KSR20.65534898
69CDK40.64248763
70MAP3K70.63001535
71EPHB10.61869166
72JAK20.59853758
73MAP3K120.59375067
74NEK20.58809371
75PDK10.58141119
76MAPK40.57047990
77MST40.56371108
78CDC42BPA0.56207590
79SMG10.54434598
80CHUK0.54139995
81PDPK10.53087957
82MAP2K20.52861014
83ADRBK20.52693283
84IRAK30.52418844
85MAPK120.52137404
86HIPK20.51906337
87IRAK10.50377178
88EIF2AK30.49721232
89TAOK20.49636534
90TESK20.48065765
91PTK60.47433692
92TRPM70.46713377
93MAPK70.45363227
94PRKD20.44549821
95PTK2B0.42849419
96ATR0.41367509
97EPHA30.41362509
98TLK10.41234038
99MARK20.40740589
100PASK0.40179095
101FGFR20.39307441
102RPS6KA60.38812288
103MAPKAPK30.38401953
104SGK30.37540808
105FYN0.36715685
106STK240.36650309
107MAP3K50.35857999
108FRK0.34938564
109BRD40.34644592
110RET0.34202537
111STK110.34145864
112ACVR1B0.33400396
113CDK120.33325293
114CDK190.33018575
115VRK10.32236668
116SIK10.32090912
117TRIB30.31365682
118DYRK1B0.31102538
119CDK90.29358293
120SGK20.29238033
121RPS6KC10.28424081
122RPS6KL10.28424081
123ALK0.28180935
124MAP2K60.28044678
125ABL10.27143613
126CDK60.27122698
127MAPKAPK20.26649865
128GRK70.25086869
129RAF10.23862365
130PRKCD0.22316550

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.50508305
2B cell receptor signaling pathway_Homo sapiens_hsa046623.14015673
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.52905136
4T cell receptor signaling pathway_Homo sapiens_hsa046602.49936689
5Type I diabetes mellitus_Homo sapiens_hsa049402.42331488
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.39048745
7Measles_Homo sapiens_hsa051622.37753186
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.35645241
9Hematopoietic cell lineage_Homo sapiens_hsa046402.35200806
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17549233
11Osteoclast differentiation_Homo sapiens_hsa043802.14162230
12Leishmaniasis_Homo sapiens_hsa051402.12206013
13Antigen processing and presentation_Homo sapiens_hsa046122.12096751
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83123657
15DNA replication_Homo sapiens_hsa030301.74331947
16Herpes simplex infection_Homo sapiens_hsa051681.67461902
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65875910
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64739252
19Acute myeloid leukemia_Homo sapiens_hsa052211.59397934
20Ribosome_Homo sapiens_hsa030101.59393088
21Non-homologous end-joining_Homo sapiens_hsa034501.56696146
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.56616285
23Mismatch repair_Homo sapiens_hsa034301.53503419
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51601461
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.42851551
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42267362
27Chemokine signaling pathway_Homo sapiens_hsa040621.39461921
28Platelet activation_Homo sapiens_hsa046111.34137373
29Base excision repair_Homo sapiens_hsa034101.33584561
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32030045
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31607282
32Hepatitis B_Homo sapiens_hsa051611.31377725
33Allograft rejection_Homo sapiens_hsa053301.28732264
34Influenza A_Homo sapiens_hsa051641.24594914
35Toxoplasmosis_Homo sapiens_hsa051451.22545296
36Shigellosis_Homo sapiens_hsa051311.17411674
37Rheumatoid arthritis_Homo sapiens_hsa053231.11942477
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09796118
39Pancreatic cancer_Homo sapiens_hsa052121.06044032
40Chronic myeloid leukemia_Homo sapiens_hsa052201.04774580
41Viral myocarditis_Homo sapiens_hsa054161.04667947
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04387096
43Non-small cell lung cancer_Homo sapiens_hsa052231.01386200
44Apoptosis_Homo sapiens_hsa042101.00767677
45Phagosome_Homo sapiens_hsa041450.96604001
46Graft-versus-host disease_Homo sapiens_hsa053320.95926298
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93528770
48Tuberculosis_Homo sapiens_hsa051520.93409073
49Other glycan degradation_Homo sapiens_hsa005110.92500437
50Homologous recombination_Homo sapiens_hsa034400.91391781
51TNF signaling pathway_Homo sapiens_hsa046680.91118199
52Spliceosome_Homo sapiens_hsa030400.90100613
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88923695
54HTLV-I infection_Homo sapiens_hsa051660.88757967
55Staphylococcus aureus infection_Homo sapiens_hsa051500.87749264
56Epstein-Barr virus infection_Homo sapiens_hsa051690.87332857
57Legionellosis_Homo sapiens_hsa051340.87050408
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.84819733
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84546124
60Viral carcinogenesis_Homo sapiens_hsa052030.83592798
61Colorectal cancer_Homo sapiens_hsa052100.81893066
62Pertussis_Homo sapiens_hsa051330.81249826
63Malaria_Homo sapiens_hsa051440.77527181
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77425328
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75185373
66Hepatitis C_Homo sapiens_hsa051600.72726589
67Inositol phosphate metabolism_Homo sapiens_hsa005620.72039738
68Nucleotide excision repair_Homo sapiens_hsa034200.68335698
69VEGF signaling pathway_Homo sapiens_hsa043700.67332214
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66694081
71RNA degradation_Homo sapiens_hsa030180.65593761
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63447079
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63223177
74Salmonella infection_Homo sapiens_hsa051320.61306170
75Fanconi anemia pathway_Homo sapiens_hsa034600.61161503
76Autoimmune thyroid disease_Homo sapiens_hsa053200.61020850
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60306504
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60058755
79Prolactin signaling pathway_Homo sapiens_hsa049170.59006439
80Small cell lung cancer_Homo sapiens_hsa052220.55907842
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54458410
82p53 signaling pathway_Homo sapiens_hsa041150.54101853
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.52992690
84Renal cell carcinoma_Homo sapiens_hsa052110.52440666
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52151811
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51597072
87Asthma_Homo sapiens_hsa053100.50071054
88Systemic lupus erythematosus_Homo sapiens_hsa053220.48959283
89African trypanosomiasis_Homo sapiens_hsa051430.48885372
90Cell cycle_Homo sapiens_hsa041100.48672303
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.48043443
92FoxO signaling pathway_Homo sapiens_hsa040680.43625444
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43190644
94Regulation of autophagy_Homo sapiens_hsa041400.42712455
95mTOR signaling pathway_Homo sapiens_hsa041500.41799254
96Notch signaling pathway_Homo sapiens_hsa043300.40821667
97GnRH signaling pathway_Homo sapiens_hsa049120.39854402
98Dorso-ventral axis formation_Homo sapiens_hsa043200.39574127
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.38256352
100Lysosome_Homo sapiens_hsa041420.37163670
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36461190
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36316343
103Pentose phosphate pathway_Homo sapiens_hsa000300.35534335
104Insulin resistance_Homo sapiens_hsa049310.34536575
105Long-term potentiation_Homo sapiens_hsa047200.33235218
106N-Glycan biosynthesis_Homo sapiens_hsa005100.32979996
107Endometrial cancer_Homo sapiens_hsa052130.32817732
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31702374
109HIF-1 signaling pathway_Homo sapiens_hsa040660.30780420
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30509480
111MAPK signaling pathway_Homo sapiens_hsa040100.29987968
112Endocytosis_Homo sapiens_hsa041440.29948924
113Thyroid cancer_Homo sapiens_hsa052160.28367536
114mRNA surveillance pathway_Homo sapiens_hsa030150.28331212
115Choline metabolism in cancer_Homo sapiens_hsa052310.28062093
116Prostate cancer_Homo sapiens_hsa052150.27507665
117Caffeine metabolism_Homo sapiens_hsa002320.27429706
118Type II diabetes mellitus_Homo sapiens_hsa049300.27084365
119Rap1 signaling pathway_Homo sapiens_hsa040150.26666530
120Ras signaling pathway_Homo sapiens_hsa040140.24779449
121ErbB signaling pathway_Homo sapiens_hsa040120.22384235
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20714949

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