IL17B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)9.68933658
2notochord development (GO:0030903)8.32506043
3regulation of response to osmotic stress (GO:0047484)7.86008001
4piRNA metabolic process (GO:0034587)7.84501605
5regulation of female gonad development (GO:2000194)7.67020920
6multicellular organism reproduction (GO:0032504)6.89278277
7aminoglycoside antibiotic metabolic process (GO:0030647)6.67950373
8somite rostral/caudal axis specification (GO:0032525)6.52461497
9maintenance of protein location in nucleus (GO:0051457)6.30855347
10regulation of DNA methylation (GO:0044030)6.29857180
11oocyte development (GO:0048599)6.12712942
12positive regulation of uterine smooth muscle contraction (GO:0070474)6.08560076
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.95849842
14regulation of mammary gland epithelial cell proliferation (GO:0033599)5.93918160
15keratan sulfate catabolic process (GO:0042340)5.93012685
16meiotic cell cycle (GO:0051321)5.72734703
17cell aggregation (GO:0098743)5.55870649
18cartilage condensation (GO:0001502)5.55870649
19regulation of female receptivity (GO:0045924)5.51483755
20negative regulation of telomerase activity (GO:0051974)5.46295554
21negative regulation of epidermis development (GO:0045683)5.42331753
22negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.39631762
23muscle filament sliding (GO:0030049)5.37447527
24actin-myosin filament sliding (GO:0033275)5.37447527
25male meiosis I (GO:0007141)5.36953349
26regulation of telomere maintenance via telomerase (GO:0032210)5.34113398
27protein localization to kinetochore (GO:0034501)5.29858618
28protein kinase C signaling (GO:0070528)5.28584212
29muscle organ morphogenesis (GO:0048644)5.26251438
30glycine transport (GO:0015816)5.24669811
31rRNA transcription (GO:0009303)5.20798430
32regulation of nuclear cell cycle DNA replication (GO:0033262)5.09367436
33skeletal muscle contraction (GO:0003009)5.05230048
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.98335661
35DNA methylation involved in gamete generation (GO:0043046)4.95064028
36negative regulation of reproductive process (GO:2000242)4.92421900
37positive regulation of humoral immune response (GO:0002922)4.91682029
38negative regulation of cell cycle G2/M phase transition (GO:1902750)4.75186970
39phenol-containing compound catabolic process (GO:0019336)4.71686995
40DNA deamination (GO:0045006)4.67611969
41regulation of uterine smooth muscle contraction (GO:0070472)4.59930054
42actin-mediated cell contraction (GO:0070252)4.59029493
43regulation of cilium movement (GO:0003352)4.58583635
44female mating behavior (GO:0060180)4.56640890
45tachykinin receptor signaling pathway (GO:0007217)4.55729591
46histone H4-K5 acetylation (GO:0043981)4.54922609
47histone H4-K8 acetylation (GO:0043982)4.54922609
48meiosis I (GO:0007127)4.53386931
49reproduction (GO:0000003)4.52257930
50regulation of MHC class I biosynthetic process (GO:0045343)4.50972412
51pyrimidine ribonucleoside catabolic process (GO:0046133)4.49941413
52regulation of apoptotic process involved in morphogenesis (GO:1902337)4.49092939
53positive regulation of DNA-dependent DNA replication (GO:2000105)4.47343185
54quinone metabolic process (GO:1901661)4.47125994
55regulation of skeletal muscle contraction (GO:0014819)4.46856946
56rRNA methylation (GO:0031167)4.38287137
57chondrocyte development (GO:0002063)4.36025143
58histone H4-K12 acetylation (GO:0043983)4.35110499
59nucleoside transmembrane transport (GO:1901642)4.33609259
60regulation of translation in response to stress (GO:0043555)4.32306810
61hormone catabolic process (GO:0042447)4.31229421
62histone H3-K9 demethylation (GO:0033169)4.31027350
63synapsis (GO:0007129)4.23536556
64coenzyme catabolic process (GO:0009109)4.22572871
65negative regulation of telomere maintenance (GO:0032205)4.21374488
66cytidine deamination (GO:0009972)4.20322763
67cytidine metabolic process (GO:0046087)4.20322763
68cytidine catabolic process (GO:0006216)4.20322763
69bone trabecula formation (GO:0060346)4.20321213
70nucleotide-sugar biosynthetic process (GO:0009226)4.18900142
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18188059
72rRNA modification (GO:0000154)4.15166788
73negative regulation of epidermal cell differentiation (GO:0045605)4.14919450
74intestinal epithelial cell development (GO:0060576)4.12270034
75maintenance of protein localization in organelle (GO:0072595)4.11017190
76hypotonic response (GO:0006971)4.06449988
77regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.05782457
78branching involved in mammary gland duct morphogenesis (GO:0060444)4.03078916
79interferon-gamma production (GO:0032609)4.02579399
80GDP-mannose metabolic process (GO:0019673)3.99989082
81female gamete generation (GO:0007292)3.98307647
82icosanoid secretion (GO:0032309)3.96336770
83arachidonic acid secretion (GO:0050482)3.96336770
84mitotic sister chromatid segregation (GO:0000070)3.91191368
85gene silencing by RNA (GO:0031047)3.90981625
86attachment of spindle microtubules to kinetochore (GO:0008608)3.90453668
87cullin deneddylation (GO:0010388)3.89337352
88heterochromatin organization (GO:0070828)3.88466751
89male meiosis (GO:0007140)3.85637047
90mitotic chromosome condensation (GO:0007076)3.85482832
91N-terminal protein amino acid acetylation (GO:0006474)3.84543479
92response to dietary excess (GO:0002021)3.84220817
93protein localization to chromosome, centromeric region (GO:0071459)3.78878784
94binding of sperm to zona pellucida (GO:0007339)3.73651021
95regulation of meiosis I (GO:0060631)3.72461795
96negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.68884532
97positive regulation of reproductive process (GO:2000243)3.68733646
98mitochondrion distribution (GO:0048311)3.65826433
99negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.63384311
100microtubule severing (GO:0051013)3.62125829
101protein polyglutamylation (GO:0018095)3.61539061
102sarcoplasmic reticulum calcium ion transport (GO:0070296)3.61536697
103primitive streak formation (GO:0090009)3.56801989
104cellular modified amino acid catabolic process (GO:0042219)3.54405767
105sleep (GO:0030431)3.51159988
106negative regulation of cAMP-mediated signaling (GO:0043951)3.49777436
107cell fate commitment involved in formation of primary germ layer (GO:0060795)3.47178304
108negative regulation of potassium ion transmembrane transport (GO:1901380)3.46319772
109positive regulation of catecholamine secretion (GO:0033605)3.43753336
110chromatin assembly (GO:0031497)3.42232818
111cardiovascular system development (GO:0072358)3.41780474
112intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.41247607
113intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.40792557
114positive regulation of muscle cell apoptotic process (GO:0010661)3.39972654
115vitamin A metabolic process (GO:0006776)3.39051712
116proline transport (GO:0015824)3.38553024
117drinking behavior (GO:0042756)3.37070944
118phagocytosis, recognition (GO:0006910)3.36327257
119aggressive behavior (GO:0002118)3.34910434
120protein deneddylation (GO:0000338)3.34298927
121regulation of telomerase activity (GO:0051972)3.34243441
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32837384
123transepithelial transport (GO:0070633)3.32546942
124regulation of telomere maintenance (GO:0032204)3.32068524
125DNA replication-dependent nucleosome assembly (GO:0006335)3.31531599
126DNA replication-dependent nucleosome organization (GO:0034723)3.31531599
127negative regulation of digestive system process (GO:0060457)3.30162339
128pyrimidine dimer repair (GO:0006290)3.28706958
129chromosome organization involved in meiosis (GO:0070192)3.27312132
130nucleoside transport (GO:0015858)3.26257605
131meiotic nuclear division (GO:0007126)3.25684820
132positive regulation of digestive system process (GO:0060456)3.25353490
133retinal cone cell development (GO:0046549)3.24957988
134histone H4-K16 acetylation (GO:0043984)3.24857127
135regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22815404
136nuclear pore complex assembly (GO:0051292)3.22808597
137regulation of histone H3-K9 methylation (GO:0051570)3.17645698
138single fertilization (GO:0007338)3.17458157
139sister chromatid segregation (GO:0000819)3.17134584
140ribosome biogenesis (GO:0042254)3.15227478
141regulation of calcium ion-dependent exocytosis (GO:0017158)3.14449381
142ventricular system development (GO:0021591)3.13140951
143positive regulation of protein deacetylation (GO:0090312)3.12578635
144sperm-egg recognition (GO:0035036)3.09761463
145positive regulation of prostaglandin secretion (GO:0032308)3.08953987
146negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.08350472
147fertilization (GO:0009566)3.08046130
148cellular response to pH (GO:0071467)3.07567047
149calcium-mediated signaling using intracellular calcium source (GO:0035584)3.07139779
150hyperosmotic salinity response (GO:0042538)3.06219397
151synaptonemal complex assembly (GO:0007130)3.06104377
152fatty acid derivative transport (GO:1901571)3.05986609
153icosanoid transport (GO:0071715)3.05986609
154regulation of G0 to G1 transition (GO:0070316)3.05191146
155regulation of reproductive process (GO:2000241)3.04509939
156embryonic skeletal joint morphogenesis (GO:0060272)3.04444230
157negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.03303514
158negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.02119416
159negative regulation of retinoic acid receptor signaling pathway (GO:0048387)22.5644504
160DNA replication checkpoint (GO:0000076)2.98905561
161actin filament-based movement (GO:0030048)2.97963956
162regulation of steroid hormone secretion (GO:2000831)2.91718746
163skeletal muscle tissue regeneration (GO:0043403)2.90764049
164positive regulation of myotube differentiation (GO:0010831)2.86628568
165synaptonemal complex organization (GO:0070193)2.85462307
166meiotic cell cycle process (GO:1903046)2.84813119
167regulation of norepinephrine secretion (GO:0014061)2.81889057
168regulation of penile erection (GO:0060405)2.79828937
169dopamine biosynthetic process (GO:0042416)2.76282695
170phosphorelay signal transduction system (GO:0000160)2.75463433
171regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74695665
172regulation of spindle organization (GO:0090224)2.74043850
173response to inactivity (GO:0014854)2.73207292
174positive regulation of meiosis (GO:0045836)2.69104435
175positive regulation of meiotic cell cycle (GO:0051446)2.68370226
176striated muscle contraction (GO:0006941)2.68249935
177response to lipoprotein particle (GO:0055094)2.68024911
178myoblast fusion (GO:0007520)2.67662388
179L-amino acid import (GO:0043092)2.64420447
180regulation of meiosis (GO:0040020)2.63402093
181response to acidic pH (GO:0010447)2.60486614
182response to caffeine (GO:0031000)2.57928796
183positive regulation of myoblast differentiation (GO:0045663)2.57780421
184gene silencing (GO:0016458)2.52986731
185regulation of prostaglandin secretion (GO:0032306)2.52959292
186mitotic metaphase plate congression (GO:0007080)2.49061527
187positive regulation of renal sodium excretion (GO:0035815)2.48519848
188positive regulation of endothelial cell differentiation (GO:0045603)2.47687685
189regulation of cell maturation (GO:1903429)2.46141643
190regulation of retinoic acid receptor signaling pathway (GO:0048385)18.8929630
191doxorubicin metabolic process (GO:0044598)10.4241133
192daunorubicin metabolic process (GO:0044597)10.4241133
193polyketide metabolic process (GO:0030638)10.4241133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.04743382
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse7.01772301
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse7.01772301
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse7.01772301
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.29604714
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.85908449
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.40162376
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.33741641
9ZNF274_21170338_ChIP-Seq_K562_Hela3.21447437
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.02991609
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91869074
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84412169
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.70885032
14E2F7_22180533_ChIP-Seq_HELA_Human2.68719084
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.68305649
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60985070
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57321376
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53499346
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.48833753
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.42498308
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40463432
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.35341331
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.32012279
24VDR_22108803_ChIP-Seq_LS180_Human2.08826777
25EZH2_22144423_ChIP-Seq_EOC_Human11.5529242
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.99996728
27GBX2_23144817_ChIP-Seq_PC3_Human1.99555248
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97967180
29NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.90684756
30NANOG_20526341_ChIP-Seq_ESCs_Human1.85394317
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.78472126
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71287024
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67967707
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67875947
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.67338214
36TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.67049726
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66567952
38IRF1_19129219_ChIP-ChIP_H3396_Human1.65706905
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.63003332
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61811097
41HTT_18923047_ChIP-ChIP_STHdh_Human1.60233532
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59934830
43PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.59825113
44POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54768380
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52049885
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46660638
47NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44547052
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.42658747
49NANOG_18692474_ChIP-Seq_MESCs_Mouse1.41229876
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39725188
51E2F1_17053090_ChIP-ChIP_MCF-7_Human1.39025065
52POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38554110
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.38344015
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35664246
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34428235
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32933886
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31719804
58BCAT_22108803_ChIP-Seq_LS180_Human1.31038059
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.30731124
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28842820
61OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27615634
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27201859
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26617969
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.26134055
65NANOG_16518401_ChIP-PET_MESCs_Mouse1.25494983
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25473937
67FOXH1_21741376_ChIP-Seq_ESCs_Human1.25257959
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25214115
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25187794
70CBP_20019798_ChIP-Seq_JUKART_Human1.25187794
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.24790735
72SMAD4_21799915_ChIP-Seq_A2780_Human1.23536230
73TBL1_22424771_ChIP-Seq_293T_Human1.22665628
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22378884
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.20610472
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.20183091
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20054902
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.19982330
79TP53_22573176_ChIP-Seq_HFKS_Human1.19166018
80* RAC3_21632823_ChIP-Seq_H3396_Human1.19135855
81NFYB_21822215_ChIP-Seq_K562_Human1.19133171
82* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18701944
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18669361
84TCF4_23295773_ChIP-Seq_U87_Human1.18412659
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17714521
86ETV1_20927104_ChIP-Seq_GIST48_Human1.17540618
87* FOXH1_21741376_ChIP-Seq_EPCs_Human1.17123887
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16723161
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.15607945
90SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14842242
91* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14653920
92TP53_22127205_ChIP-Seq_IMR90_Human1.14592291
93SOX2_19829295_ChIP-Seq_ESCs_Human1.13731774
94NANOG_19829295_ChIP-Seq_ESCs_Human1.13731774
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.13574214
96CTCF_20526341_ChIP-Seq_ESCs_Human1.13191065
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.12288782
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12188469
99RBPJ_21746931_ChIP-Seq_IB4_Human1.11719716
100KLF4_19829295_ChIP-Seq_ESCs_Human1.11571894
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.11165483
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08277247
103TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07114384
104ELK1_22589737_ChIP-Seq_MCF10A_Human1.06573295
105RUNX2_22187159_ChIP-Seq_PCA_Human1.06477805
106SOX2_21211035_ChIP-Seq_LN229_Human1.05930415
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05915592
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05700327
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05363904
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.04839398
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04369706
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03539204
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03151192
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02651896
115GF1_26923725_Chip-Seq_HPCs_Mouse1.02279998
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01100702
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00892529
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.00158872
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98029253
120KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97396216
121MYC_18940864_ChIP-ChIP_HL60_Human0.96245566
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95415152
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95098780
124GATA3_26560356_Chip-Seq_TH1_Human0.94177847
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.93330357
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92695848
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92184084
128P53_21459846_ChIP-Seq_SAOS-2_Human0.92122725
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92119207
130STAT3_18555785_ChIP-Seq_MESCs_Mouse0.92111460
131IGF1R_20145208_ChIP-Seq_DFB_Human0.91840411
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90752965
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.90741682
134PHF8_20622853_ChIP-Seq_HELA_Human0.90594051
135MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90404778
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.88304842
137AR_25329375_ChIP-Seq_VCAP_Human0.87790262
138* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87334248
139STAT3_23295773_ChIP-Seq_U87_Human0.87029001
140RXR_22108803_ChIP-Seq_LS180_Human0.86970645
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.86863822
142* OCT4_20526341_ChIP-Seq_ESCs_Human0.86767978
143GATA1_22025678_ChIP-Seq_K562_Human0.86704766
144KDM2B_26808549_Chip-Seq_K562_Human0.86148294
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85768678
146CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84389452
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84082354
148* CTCF_21964334_Chip-Seq_Bcells_Human0.84045231
149SMC4_20622854_ChIP-Seq_HELA_Human0.83709647
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83603812
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.83326619
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.81592836
153OCT4_19829295_ChIP-Seq_ESCs_Human0.80703487
154TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79503654
155* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79467259
156RNF2_27304074_Chip-Seq_NSC_Mouse0.79309262
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79268424
158WT1_19549856_ChIP-ChIP_CCG9911_Human0.78973923
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78794033
160KAP1_27257070_Chip-Seq_ESCs_Mouse0.78346928
161SMRT_27268052_Chip-Seq_Bcells_Human0.78235748
162E2F1_20622854_ChIP-Seq_HELA_Human0.77740152
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77264986
164RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77010301
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76779127
166CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76328083
167EED_16625203_ChIP-ChIP_MESCs_Mouse0.76119119
168GABP_17652178_ChIP-ChIP_JURKAT_Human0.75909409
169FLI1_21867929_ChIP-Seq_CD8_Mouse0.75806038
170YY1_22570637_ChIP-Seq_MALME-3M_Human0.75576658
171BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75302950
172NCOR1_26117541_ChIP-Seq_K562_Human0.74556000
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74487797
174ELK4_26923725_Chip-Seq_MESODERM_Mouse0.73729836
175FOXO3_23340844_ChIP-Seq_DLD1_Human0.73516466
176ELF1_20517297_ChIP-Seq_JURKAT_Human0.72984585
177STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72736612
178RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.72650300
179KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.71608662
180IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71401015
181HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71169340
182WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70391153
183SPI1_26923725_Chip-Seq_HPCs_Mouse0.70206442
184HOXB7_26014856_ChIP-Seq_BT474_Human0.69681733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.81081258
2MP0003950_abnormal_plasma_membrane5.06908081
3MP0003011_delayed_dark_adaptation4.46014635
4MP0002254_reproductive_system_inflammat3.95933722
5MP0004264_abnormal_extraembryonic_tissu3.68116920
6MP0006292_abnormal_olfactory_placode3.50482188
7MP0005360_urolithiasis3.47987473
8MP0008877_abnormal_DNA_methylation3.31011508
9MP0003122_maternal_imprinting3.20153186
10MP0005394_taste/olfaction_phenotype3.09448060
11MP0005499_abnormal_olfactory_system3.09448060
12MP0001986_abnormal_taste_sensitivity2.83654420
13MP0004145_abnormal_muscle_electrophysio2.82785709
14MP0003121_genomic_imprinting2.78385370
15MP0003123_paternal_imprinting2.74788647
16MP0005075_abnormal_melanosome_morpholog2.67723574
17MP0000751_myopathy2.64733429
18MP0000762_abnormal_tongue_morphology2.64275803
19MP0003890_abnormal_embryonic-extraembry2.61656683
20MP0005395_other_phenotype2.61012371
21MP0002332_abnormal_exercise_endurance2.57761571
22MP0006276_abnormal_autonomic_nervous2.57079620
23MP0003879_abnormal_hair_cell2.48193377
24MP0004134_abnormal_chest_morphology2.42405138
25MP0000163_abnormal_cartilage_morphology2.37402007
26MP0004858_abnormal_nervous_system2.37021148
27MP0002282_abnormal_trachea_morphology2.35294688
28MP0001929_abnormal_gametogenesis2.27435497
29MP0008057_abnormal_DNA_replication2.26038236
30MP0009250_abnormal_appendicular_skeleto2.22189793
31MP0002269_muscular_atrophy2.17593144
32MP0003705_abnormal_hypodermis_morpholog2.10166022
33MP0003787_abnormal_imprinting2.09451018
34MP0002210_abnormal_sex_determination2.09366582
35MP0005257_abnormal_intraocular_pressure2.08557410
36MP0009379_abnormal_foot_pigmentation2.07617020
37MP0002160_abnormal_reproductive_system2.07292275
38MP0000759_abnormal_skeletal_muscle2.04170568
39MP0002102_abnormal_ear_morphology2.02590480
40MP0000049_abnormal_middle_ear1.93678753
41MP0004957_abnormal_blastocyst_morpholog1.90777385
42MP0002138_abnormal_hepatobiliary_system1.86277347
43MP0002233_abnormal_nose_morphology1.85699813
44MP0005410_abnormal_fertilization1.83496148
45MP0002933_joint_inflammation1.83027768
46MP0009840_abnormal_foam_cell1.82353860
47MP0010030_abnormal_orbit_morphology1.80451841
48MP0005508_abnormal_skeleton_morphology1.79381321
49MP0003755_abnormal_palate_morphology1.75171231
50MP0002653_abnormal_ependyma_morphology1.72601867
51MP0005389_reproductive_system_phenotype1.71400171
52MP0001270_distended_abdomen1.71186737
53MP0000678_abnormal_parathyroid_gland1.71075490
54MP0004270_analgesia1.70994860
55MP0002909_abnormal_adrenal_gland1.70337628
56MP0003693_abnormal_embryo_hatching1.70317787
57MP0000733_abnormal_muscle_development1.70131758
58MP0003699_abnormal_female_reproductive1.69734046
59MP0004087_abnormal_muscle_fiber1.65549233
60MP0003938_abnormal_ear_development1.63379121
61MP0002932_abnormal_joint_morphology1.60444612
62MP0002106_abnormal_muscle_physiology1.59605302
63MP0005369_muscle_phenotype1.58545072
64MP0006035_abnormal_mitochondrial_morpho1.57660627
65MP0000653_abnormal_sex_gland1.53538952
66MP0010307_abnormal_tumor_latency1.52980151
67MP0000432_abnormal_head_morphology1.52177698
68MP0003646_muscle_fatigue1.52082432
69MP0002114_abnormal_axial_skeleton1.49929236
70MP0002116_abnormal_craniofacial_bone1.46990680
71MP0003283_abnormal_digestive_organ1.44964539
72MP0002249_abnormal_larynx_morphology1.42697198
73MP0002109_abnormal_limb_morphology1.38882178
74MP0001672_abnormal_embryogenesis/_devel1.36877060
75MP0005380_embryogenesis_phenotype1.36877060
76MP0004036_abnormal_muscle_relaxation1.36262990
77MP0004233_abnormal_muscle_weight1.35241576
78MP0010352_gastrointestinal_tract_polyps1.34629366
79MP0002115_abnormal_skeleton_extremities1.34259493
80MP0003935_abnormal_craniofacial_develop1.32410822
81MP0008438_abnormal_cutaneous_collagen1.31922449
82MP0008789_abnormal_olfactory_epithelium1.30599892
83MP0002088_abnormal_embryonic_growth/wei1.30310437
84MP0005620_abnormal_muscle_contractility1.30047960
85MP0002113_abnormal_skeleton_development1.29237215
86MP0003984_embryonic_growth_retardation1.27726319
87MP0004084_abnormal_cardiac_muscle1.25870114
88MP0005330_cardiomyopathy1.24030737
89MP0003183_abnormal_peptide_metabolism1.23603747
90MP0004197_abnormal_fetal_growth/weight/1.22817329
91MP0010368_abnormal_lymphatic_system1.21355364
92MP0003119_abnormal_digestive_system1.20541920
93MP0001849_ear_inflammation1.20488289
94MP0010234_abnormal_vibrissa_follicle1.18926661
95MP0004215_abnormal_myocardial_fiber1.16206542
96MP0005503_abnormal_tendon_morphology1.15972454
97MP0002127_abnormal_cardiovascular_syste1.14787483
98MP0002277_abnormal_respiratory_mucosa1.14699569
99MP0004142_abnormal_muscle_tone1.14437548
100MP0005647_abnormal_sex_gland1.13737018
101MP0005646_abnormal_pituitary_gland1.12978440
102MP0003941_abnormal_skin_development1.12881149
103MP0003937_abnormal_limbs/digits/tail_de1.12805418
104MP0005248_abnormal_Harderian_gland1.12798192
105MP0001145_abnormal_male_reproductive1.11611521
106MP0002161_abnormal_fertility/fecundity1.10974467
107MP0005390_skeleton_phenotype1.09850481
108MP0001293_anophthalmia1.09114974
109MP0001119_abnormal_female_reproductive1.08035111
110MP0003698_abnormal_male_reproductive1.06793244
111MP0002751_abnormal_autonomic_nervous1.06503976
112MP0008961_abnormal_basal_metabolism1.06223431
113MP0003136_yellow_coat_color1.05874827
114MP0003315_abnormal_perineum_morphology1.04354540
115MP0001664_abnormal_digestion1.03928460
116MP0002111_abnormal_tail_morphology1.03761465
117MP0002876_abnormal_thyroid_physiology1.03541294
118MP0006082_CNS_inflammation1.02620369
119MP0000428_abnormal_craniofacial_morphol1.02515904
120MP0000350_abnormal_cell_proliferation1.01568964
121MP0002092_abnormal_eye_morphology1.00034977
122MP0001348_abnormal_lacrimal_gland0.98971016
123MP0002163_abnormal_gland_morphology0.97866237
124MP0009333_abnormal_splenocyte_physiolog0.97762084
125MP0000372_irregular_coat_pigmentation0.97682669
126MP0003567_abnormal_fetal_cardiomyocyte0.95388266
127MP0000747_muscle_weakness0.93354476
128MP0004043_abnormal_pH_regulation0.92112936
129MP0001286_abnormal_eye_development0.90488582
130MP0002086_abnormal_extraembryonic_tissu0.88420849
131MP0004272_abnormal_basement_membrane0.88217324
132MP0002085_abnormal_embryonic_tissue0.88119623
133MP0000631_abnormal_neuroendocrine_gland0.87948982
134MP0005266_abnormal_metabolism0.87654588
135MP0003137_abnormal_impulse_conducting0.87414237
136MP0000750_abnormal_muscle_regeneration0.86936998
137MP0004484_altered_response_of0.85669009
138MP0001919_abnormal_reproductive_system0.85033669
139MP0002139_abnormal_hepatobiliary_system0.84771187
140MP0003795_abnormal_bone_structure0.83387816
141MP0002970_abnormal_white_adipose0.83087592
142MP0008770_decreased_survivor_rate0.80586489
143MP0008058_abnormal_DNA_repair0.78478064
144MP0003942_abnormal_urinary_system0.76641472
145MP0000427_abnormal_hair_cycle0.76520482
146MP0000343_altered_response_to0.75924617
147MP0002877_abnormal_melanocyte_morpholog0.75791281
148MP0005023_abnormal_wound_healing0.75642550
149MP0005379_endocrine/exocrine_gland_phen0.75541865
150MP0002084_abnormal_developmental_patter0.75185350
151MP0000647_abnormal_sebaceous_gland0.74565137
152MP0002108_abnormal_muscle_morphology0.74531478
153MP0002098_abnormal_vibrissa_morphology0.73058602
154MP0002896_abnormal_bone_mineralization0.71849961
155MP0003111_abnormal_nucleus_morphology0.71427216
156MP0002081_perinatal_lethality0.70197208
157MP0000749_muscle_degeneration0.69912844
158MP0006036_abnormal_mitochondrial_physio0.69232784
159MP0002734_abnormal_mechanical_nocicepti0.66678420
160MP0004381_abnormal_hair_follicle0.66389546
161MP0005423_abnormal_somatic_nervous0.65950745
162MP0001542_abnormal_bone_strength0.65730165
163MP0003195_calcinosis0.65410392
164MP0005551_abnormal_eye_electrophysiolog0.64063861
165MP0003252_abnormal_bile_duct0.63204589
166MP0003077_abnormal_cell_cycle0.62366525
167MP0001502_abnormal_circadian_rhythm0.62065819
168MP0001730_embryonic_growth_arrest0.61822346
169MP0005645_abnormal_hypothalamus_physiol0.61223851
170MP0000377_abnormal_hair_follicle0.60759308
171MP0002925_abnormal_cardiovascular_devel0.60273498
172MP0001544_abnormal_cardiovascular_syste0.60187578
173MP0005385_cardiovascular_system_phenoty0.60187578

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)7.72468597
2Ulnar deviation of the wrist (HP:0003049)7.61241605
3Irregular epiphyses (HP:0010582)7.59638367
4Popliteal pterygium (HP:0009756)7.14873804
5Epiphyseal dysplasia (HP:0002656)6.91220859
6Malignant hyperthermia (HP:0002047)6.34421761
7Fetal akinesia sequence (HP:0001989)6.28122765
8Calcaneovalgus deformity (HP:0001848)6.13290608
9Aplasia of the musculature (HP:0100854)5.76844692
10Vitreoretinal degeneration (HP:0000655)5.68955988
11Absent phalangeal crease (HP:0006109)5.58036139
12Deformed tarsal bones (HP:0008119)5.43845674
13Flat capital femoral epiphysis (HP:0003370)5.18595929
14Small epiphyses (HP:0010585)5.08583117
15Abnormality of placental membranes (HP:0011409)5.03666502
16Amniotic constriction ring (HP:0009775)5.03666502
17Type 2 muscle fiber atrophy (HP:0003554)5.01506806
18Bilateral microphthalmos (HP:0007633)4.77376523
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.67354814
20Hepatoblastoma (HP:0002884)4.66181395
21Hypoplastic ischia (HP:0003175)4.63815316
22Abnormal finger flexion creases (HP:0006143)4.60977957
23Nemaline bodies (HP:0003798)4.50963944
24Aplasia/Hypoplasia involving the musculature (HP:0001460)4.43572718
25Abnormal tarsal ossification (HP:0008369)4.43250260
26Muscle fiber atrophy (HP:0100295)4.30361388
27Delayed epiphyseal ossification (HP:0002663)4.28738268
28Cupped ribs (HP:0000887)4.25023012
29Flat acetabular roof (HP:0003180)4.21110257
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.19493859
31Muscle fiber inclusion bodies (HP:0100299)4.16436967
32Genu varum (HP:0002970)4.07016564
33Abnormality of the ischium (HP:0003174)4.02784655
34Abnormality of the pubic bones (HP:0003172)3.83256142
35Metaphyseal cupping (HP:0003021)3.81415624
36Abnormality of the neuromuscular junction (HP:0003398)3.65831057
37Fatigable weakness (HP:0003473)3.65831057
38Arthropathy (HP:0003040)3.65328956
39Male infertility (HP:0003251)3.62907995
40Hypochromic microcytic anemia (HP:0004840)3.60904328
41Neonatal short-limb short stature (HP:0008921)3.56564008
42Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.53650574
43Abnormality of femoral epiphyses (HP:0006499)3.53650574
44Hypophosphatemic rickets (HP:0004912)3.51861689
45Flattened epiphyses (HP:0003071)3.48674729
46Glossoptosis (HP:0000162)3.47460299
47Weak cry (HP:0001612)3.43299730
48Osteomalacia (HP:0002749)3.40700201
49Mild short stature (HP:0003502)3.39285256
50Breech presentation (HP:0001623)3.35871171
51Metatarsus adductus (HP:0001840)3.33277958
52Abnormality of the calcaneus (HP:0008364)3.26935285
53Abnormality of the epiphysis of the femoral head (HP:0010574)3.26740390
54Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.21258177
55Absent epiphyses (HP:0010577)3.21258177
56Anterior segment dysgenesis (HP:0007700)3.13917629
57Muscle stiffness (HP:0003552)3.13827754
58Osteoarthritis (HP:0002758)3.12984785
59Muscle fiber splitting (HP:0003555)3.11614197
60Multiple enchondromatosis (HP:0005701)3.11122742
61Abnormal auditory evoked potentials (HP:0006958)3.09241268
62Gowers sign (HP:0003391)2.99971866
63Rib fusion (HP:0000902)2.99623866
64Abnormality of the lower motor neuron (HP:0002366)2.99226205
65Carpal bone hypoplasia (HP:0001498)2.97612481
66Abnormality of the femoral head (HP:0003368)2.97422353
67Abnormal foot bone ossification (HP:0010675)2.95415155
68Type 1 muscle fiber predominance (HP:0003803)2.90373122
69Abnormal cartilage morphology (HP:0002763)2.89279274
70Infertility (HP:0000789)2.84532989
71Premature ovarian failure (HP:0008209)2.82857136
72Akinesia (HP:0002304)2.79459294
73Abnormality of the vertebral endplates (HP:0005106)2.79061767
74Neoplasm of the heart (HP:0100544)2.77075885
75Short femoral neck (HP:0100864)2.76682149
76Calf muscle hypertrophy (HP:0008981)2.74501642
77Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.74117210
78Vertebral clefting (HP:0008428)2.67680518
79Abnormality of carpal bone ossification (HP:0006257)2.65795102
80Metaphyseal irregularity (HP:0003025)2.64755309
81Thoracolumbar scoliosis (HP:0002944)2.54105265
82Nephroblastoma (Wilms tumor) (HP:0002667)2.53959321
83Hyporeflexia of lower limbs (HP:0002600)2.51376828
84Irregular vertebral endplates (HP:0003301)2.49017783
85Abnormal vertebral ossification (HP:0100569)2.48848418
86Abnormality of the proximal phalanges of the hand (HP:0009834)2.46360402
87Short 5th finger (HP:0009237)2.45761750
88Aplasia/Hypoplasia of the scapulae (HP:0006713)2.45312405
89Hypoplastic scapulae (HP:0000882)2.45312405
90Absent frontal sinuses (HP:0002688)2.45067989
91Mesomelia (HP:0003027)2.44849021
92Symphalangism affecting the phalanges of the hand (HP:0009773)2.39247333
93Muscle hypertrophy of the lower extremities (HP:0008968)2.36287435
94Embryonal renal neoplasm (HP:0011794)2.35477931
95Exercise-induced myalgia (HP:0003738)2.35411665
96Pterygium (HP:0001059)2.28830649
97Chin dimple (HP:0010751)2.28444251
98Metaphyseal dysplasia (HP:0100255)2.28355325
99Myopathic facies (HP:0002058)2.27320603
100Easy fatigability (HP:0003388)2.26985622
101Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.25188277
102Abnormality of the calf musculature (HP:0001430)2.24754919
103Malnutrition (HP:0004395)2.23546102
104Short middle phalanx of finger (HP:0005819)2.22252511
105Relative macrocephaly (HP:0004482)2.21214040
106Waddling gait (HP:0002515)2.17978494
107Stillbirth (HP:0003826)2.17907938
108Neck muscle weakness (HP:0000467)2.16849413
109Hypercortisolism (HP:0001578)2.16805083
110Limited elbow extension (HP:0001377)2.16093845
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14650437
112Platyspondyly (HP:0000926)2.14231385
113Nonprogressive disorder (HP:0003680)2.13818523
114Diminished movement (HP:0002374)2.13760398
115Hypoplastic heart (HP:0001961)2.12799297
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.12775103
117Ependymoma (HP:0002888)2.12680542
118Hip contracture (HP:0003273)2.12589304
119Limited hip movement (HP:0008800)2.12240477
120Abnormality of the distal phalanx of the thumb (HP:0009617)2.12237004
121Partial duplication of thumb phalanx (HP:0009944)2.11624004
122Abnormal hand bone ossification (HP:0010660)2.11118554
123Poor suck (HP:0002033)2.09470144
124Abnormal ossification of hand bones (HP:0005921)2.09393555
125Aplasia/Hypoplasia of the fovea (HP:0008060)2.08975812
126Hypoplasia of the fovea (HP:0007750)2.08975812
127Fused cervical vertebrae (HP:0002949)2.08646263
128Hand muscle atrophy (HP:0009130)2.08326875
129Neoplasm of striated muscle (HP:0009728)2.07416895
130Thyroid-stimulating hormone excess (HP:0002925)2.05736031
131Coxa vara (HP:0002812)2.04712721
132Broad thumb (HP:0011304)2.04464922
133Barrel-shaped chest (HP:0001552)2.03584908
134Trismus (HP:0000211)2.03425759
135Abnormality of the distal phalanges of the toes (HP:0010182)2.02635700
136Abdominal situs inversus (HP:0003363)2.01825081
137Abnormality of abdominal situs (HP:0011620)2.01825081
138Protuberant abdomen (HP:0001538)2.01348081
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01190614
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.00721145
141Cervical subluxation (HP:0003308)2.00474216
142Distal arthrogryposis (HP:0005684)10.1856800
143Aplasia/hypoplasia of the femur (HP:0005613)1.99927964
144Aplasia/hypoplasia of the humerus (HP:0006507)1.98960840
145Webbed neck (HP:0000465)1.97759812
146Sudden death (HP:0001699)1.97716775
147Ulnar deviation of finger (HP:0009465)1.96556383
148Short tibia (HP:0005736)1.96394445
149Bulbar palsy (HP:0001283)1.96346784
150Testicular atrophy (HP:0000029)1.96276690
151Abnormality of the intervertebral disk (HP:0005108)1.96072470
152Rhabdomyosarcoma (HP:0002859)1.95747435
153Horizontal nystagmus (HP:0000666)1.92050391
154Vertebral hypoplasia (HP:0008417)1.91694387
155Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.91694387
156Depressed nasal tip (HP:0000437)1.90015686
157Short humerus (HP:0005792)1.89656293
158Spinal cord compression (HP:0002176)1.89630694
159Bifid tongue (HP:0010297)1.89438841
160Thin ribs (HP:0000883)1.88803130
161Enlarged epiphyses (HP:0010580)1.87703480
162Broad phalanx (HP:0006009)1.86077361
163Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.84794190
164Pendular nystagmus (HP:0012043)1.83789641
165Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83647946
166Ulnar bowing (HP:0003031)1.82866183
167Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.82804977
168EMG: myopathic abnormalities (HP:0003458)1.80108577
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.75893518
170Tarsal synostosis (HP:0008368)1.75797777
171Respiratory insufficiency due to muscle weakness (HP:0002747)1.73492648
172Abnormality of the fovea (HP:0000493)1.71379302
173Azoospermia (HP:0000027)1.70327001
174Knee flexion contracture (HP:0006380)1.68659096
175Cystic hygroma (HP:0000476)1.68047122
176Supernumerary spleens (HP:0009799)1.67857792
177Adducted thumb (HP:0001181)1.65822178
178Proximal tubulopathy (HP:0000114)1.65551936
179Areflexia of lower limbs (HP:0002522)1.65187462
180Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.64969458
181Preauricular pit (HP:0004467)1.63108646
182Periauricular skin pits (HP:0100277)1.63108646
183Impulsivity (HP:0100710)1.62741814
184Synostosis involving bones of the feet (HP:0009140)1.62029015
185Synostosis involving bones of the lower limbs (HP:0009138)1.62029015
186Skin pits (HP:0100276)1.61094567
187Mask-like facies (HP:0000298)1.60310246
188Lip pit (HP:0100267)1.60004272
189Anhidrosis (HP:0000970)1.59908690
190Rocker bottom foot (HP:0001838)1.58932396
191Aplasia/Hypoplasia of the brainstem (HP:0007362)1.56647291
192Hypoplasia of the brainstem (HP:0002365)1.56647291
193Striae distensae (HP:0001065)1.56612680
194Asymmetric septal hypertrophy (HP:0001670)1.53562168
195Bundle branch block (HP:0011710)1.53503036
196Clumsiness (HP:0002312)1.50595250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.12187330
2GRK55.63082452
3MAP3K134.63686424
4GRK64.30553700
5ARAF4.26937246
6MAP3K94.14577725
7ERN13.97412127
8GRK13.53674425
9ADRBK23.44219415
10TLK13.16691117
11DDR22.64453845
12CDK192.61683065
13CSF1R2.59295049
14PRKG22.58376503
15TESK22.54789557
16TGFBR22.54556465
17MAPK72.53879270
18TAOK32.52082425
19GRK72.40469801
20MATK2.38062222
21TYRO32.23156247
22MAP3K32.16582066
23TTK2.07944283
24PIK3CG2.01956168
25STK162.01086396
26MOS1.94087393
27STK38L1.92156811
28BRSK11.88689895
29OBSCN1.86804932
30STK101.83767998
31KSR21.82577439
32EPHA21.73731032
33ACVR1B1.67366385
34NEK61.67219939
35NTRK11.64913251
36WNK11.62151539
37WNK41.62128715
38RAF11.59863332
39BRAF1.58322954
40NME11.57062707
41BRSK21.51536583
42STK241.45502549
43CAMK41.40160959
44NEK21.38605835
45PINK11.33310579
46BMPR1B1.31008272
47MARK21.29393943
48MAPKAPK31.28362021
49NUAK11.27648824
50CDK71.24471325
51MUSK1.24067903
52ADRBK11.23569813
53AKT31.21913281
54MAPK121.18352797
55TXK1.15187391
56MET1.13042900
57STK391.11683196
58DMPK1.09928061
59PAK41.02958587
60LIMK10.99432549
61PLK40.98025038
62KDR0.98022162
63FGFR30.97876622
64MAPK110.93200263
65ZAK0.93012900
66MAP2K40.92874492
67CCNB10.91501119
68MST40.85731910
69CHEK20.84254003
70HIPK20.83755908
71PRKG10.81158713
72EIF2AK20.80841470
73TRIM280.78519571
74PLK10.78419884
75MELK0.73782236
76DYRK1A0.72656029
77RPS6KB20.72621891
78MAP2K60.72254775
79EIF2AK30.71815945
80MAP3K100.71699352
81NTRK30.71107535
82PKN10.69984284
83LATS20.69776258
84TNIK0.69679448
85NTRK20.66295803
86TGFBR10.61358231
87PDK10.61106314
88PIM10.60832331
89AKT20.60801129
90SIK10.60280917
91PNCK0.57374374
92PRKCI0.57139881
93CHEK10.55795163
94CLK10.55481864
95PIK3CA0.55271919
96SRPK10.54507565
97CSK0.53907737
98TAOK10.53754909
99MARK30.52438429
100CAMK2A0.51247974
101EEF2K0.47834640
102CSNK1D0.44688313
103FRK0.43959362
104KSR10.43880934
105DYRK20.42524861
106OXSR10.42154463
107STK30.41741937
108MAPK40.41219669
109ALK0.40972830
110GSK3A0.39464365
111TIE10.39039840
112MAP2K10.38959860
113IGF1R0.38920944
114PDPK10.37772768
115PTK2B0.37726958
116MTOR0.36649908
117ERBB20.36557487
118AURKA0.36477544
119MAP3K70.36437063
120PRKCD0.35719708
121CDK90.34785962
122CDK80.34339565
123TAOK20.32050134
124PTK20.31166024
125RIPK10.30733464
126CDK20.29396744
127PRKCQ0.28945351
128MAP3K50.28531811
129PIM20.28310369
130LATS10.26299430
131CSNK1E0.24391712
132MAPK100.23831155
133SIK20.22569866
134PRKACG0.21680035
135PRKCG0.21530189
136ERBB30.19953211
137BUB10.19812033
138PAK10.19302855
139PRKACA0.19075581
140PRKAA10.18944523
141INSR0.17488617
142CDK40.16223423
143IKBKB0.15275078
144PRKD30.14744703
145MAPK10.14711951
146AURKB0.14303410
147PDK20.14127825
148MAPK140.13587276
149CDK10.13416881
150GSK3B0.13222015
151BMX0.12385982
152ATM0.12088082
153CDK150.11464386
154CDK11A0.11453293
155PRKD20.10794367
156ITK0.10136699
157TRPM70.09871379
158CDK180.09767204
159MAPK130.07775561
160PRPF4B0.07744384
161PLK20.07369613

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.19724944
2Vitamin B6 metabolism_Homo sapiens_hsa007506.00005173
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.05342670
4Fructose and mannose metabolism_Homo sapiens_hsa000513.79085768
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.58298554
6Dorso-ventral axis formation_Homo sapiens_hsa043203.24057042
7Arachidonic acid metabolism_Homo sapiens_hsa005903.06363077
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.81486908
9Galactose metabolism_Homo sapiens_hsa000522.77169020
10Protein digestion and absorption_Homo sapiens_hsa049742.70900403
11Oocyte meiosis_Homo sapiens_hsa041142.65968813
12ECM-receptor interaction_Homo sapiens_hsa045122.52970842
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.45515665
14Cardiac muscle contraction_Homo sapiens_hsa042602.32891190
15Linoleic acid metabolism_Homo sapiens_hsa005912.20726870
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19965020
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06027459
18Phototransduction_Homo sapiens_hsa047441.98690847
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.93033862
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90988248
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61947843
22Thyroid cancer_Homo sapiens_hsa052161.61453080
23RNA transport_Homo sapiens_hsa030131.55170762
24Hedgehog signaling pathway_Homo sapiens_hsa043401.48747010
25ABC transporters_Homo sapiens_hsa020101.47746614
26Base excision repair_Homo sapiens_hsa034101.44277418
27Ovarian steroidogenesis_Homo sapiens_hsa049131.43108018
28Other glycan degradation_Homo sapiens_hsa005111.39405273
29Basal cell carcinoma_Homo sapiens_hsa052171.36439531
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26342873
31mTOR signaling pathway_Homo sapiens_hsa041501.24612813
32Ribosome_Homo sapiens_hsa030101.21440658
33Caffeine metabolism_Homo sapiens_hsa002321.18934894
34Oxytocin signaling pathway_Homo sapiens_hsa049211.16731021
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14489309
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11384668
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05013736
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04643751
39Folate biosynthesis_Homo sapiens_hsa007901.03866034
40Mismatch repair_Homo sapiens_hsa034301.02847163
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01961434
42PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96913979
43mRNA surveillance pathway_Homo sapiens_hsa030150.96840134
44Ether lipid metabolism_Homo sapiens_hsa005650.96594344
45Morphine addiction_Homo sapiens_hsa050320.94282176
46Hippo signaling pathway_Homo sapiens_hsa043900.90948773
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90702862
48Purine metabolism_Homo sapiens_hsa002300.89044721
49Nucleotide excision repair_Homo sapiens_hsa034200.88026559
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86102305
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85915757
52Sphingolipid metabolism_Homo sapiens_hsa006000.85694371
53Primary immunodeficiency_Homo sapiens_hsa053400.85441017
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.85041292
55Bile secretion_Homo sapiens_hsa049760.82505806
56Cell cycle_Homo sapiens_hsa041100.80370589
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76939940
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.76579344
59Fanconi anemia pathway_Homo sapiens_hsa034600.76229347
60Olfactory transduction_Homo sapiens_hsa047400.74877608
61RNA degradation_Homo sapiens_hsa030180.74873891
62Focal adhesion_Homo sapiens_hsa045100.74366622
63Inositol phosphate metabolism_Homo sapiens_hsa005620.74316411
64Circadian entrainment_Homo sapiens_hsa047130.74281745
65Pathways in cancer_Homo sapiens_hsa052000.73534753
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70748585
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70363019
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68416608
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68357450
70Chemical carcinogenesis_Homo sapiens_hsa052040.68169100
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64057350
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63852680
73Wnt signaling pathway_Homo sapiens_hsa043100.63811850
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.63712871
75Insulin secretion_Homo sapiens_hsa049110.63450605
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62841586
77Salivary secretion_Homo sapiens_hsa049700.62256447
78Pyrimidine metabolism_Homo sapiens_hsa002400.62046364
79RNA polymerase_Homo sapiens_hsa030200.61841560
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61558248
81Serotonergic synapse_Homo sapiens_hsa047260.61355399
82TGF-beta signaling pathway_Homo sapiens_hsa043500.60669213
83Circadian rhythm_Homo sapiens_hsa047100.60570568
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60344463
85Proteoglycans in cancer_Homo sapiens_hsa052050.60071110
86MAPK signaling pathway_Homo sapiens_hsa040100.59802905
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59046252
88One carbon pool by folate_Homo sapiens_hsa006700.58893453
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58551791
90Viral carcinogenesis_Homo sapiens_hsa052030.58385643
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58354977
92Taste transduction_Homo sapiens_hsa047420.58224515
93MicroRNAs in cancer_Homo sapiens_hsa052060.57511399
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.56903673
95Basal transcription factors_Homo sapiens_hsa030220.56044298
96Fatty acid elongation_Homo sapiens_hsa000620.56024428
97Rap1 signaling pathway_Homo sapiens_hsa040150.54443641
98Gap junction_Homo sapiens_hsa045400.54183078
99Long-term depression_Homo sapiens_hsa047300.53889320
100T cell receptor signaling pathway_Homo sapiens_hsa046600.53853173
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.53747319
102Amphetamine addiction_Homo sapiens_hsa050310.51899617
103Bladder cancer_Homo sapiens_hsa052190.51783463
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51094194
105Prion diseases_Homo sapiens_hsa050200.49800644
106Steroid biosynthesis_Homo sapiens_hsa001000.47686611
107Huntingtons disease_Homo sapiens_hsa050160.47636535
108Choline metabolism in cancer_Homo sapiens_hsa052310.46763624
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44365897
110Spliceosome_Homo sapiens_hsa030400.44357302
111Regulation of autophagy_Homo sapiens_hsa041400.42135396
112Cholinergic synapse_Homo sapiens_hsa047250.38569232
113Starch and sucrose metabolism_Homo sapiens_hsa005000.38199556
114Ras signaling pathway_Homo sapiens_hsa040140.37739775
115* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36013112
116DNA replication_Homo sapiens_hsa030300.35593034
117Arginine and proline metabolism_Homo sapiens_hsa003300.35152764
118AMPK signaling pathway_Homo sapiens_hsa041520.34420460
119Renin-angiotensin system_Homo sapiens_hsa046140.34246388
120Renin secretion_Homo sapiens_hsa049240.34225597
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33738712
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33724272
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33340483
124Malaria_Homo sapiens_hsa051440.32990491
125African trypanosomiasis_Homo sapiens_hsa051430.32343378
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31759092
127Sulfur metabolism_Homo sapiens_hsa009200.31144026
128Selenocompound metabolism_Homo sapiens_hsa004500.31086933
129Gastric acid secretion_Homo sapiens_hsa049710.30614891
130Tight junction_Homo sapiens_hsa045300.29910627
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28176688
132Metabolic pathways_Homo sapiens_hsa011000.27964852
133Homologous recombination_Homo sapiens_hsa034400.26626600
134Acute myeloid leukemia_Homo sapiens_hsa052210.26183891
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25951525
136Dilated cardiomyopathy_Homo sapiens_hsa054140.25275678
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24703161
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24354596
139Apoptosis_Homo sapiens_hsa042100.22581472
140p53 signaling pathway_Homo sapiens_hsa041150.22147998
141Sulfur relay system_Homo sapiens_hsa041220.22078668
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.21112529
143Glutamatergic synapse_Homo sapiens_hsa047240.20576739
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20281877
145Parkinsons disease_Homo sapiens_hsa050120.20185293
146GABAergic synapse_Homo sapiens_hsa047270.20044894
147Small cell lung cancer_Homo sapiens_hsa052220.19620944
148GnRH signaling pathway_Homo sapiens_hsa049120.19581942
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18590532
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.16086715
151VEGF signaling pathway_Homo sapiens_hsa043700.15753090
152cAMP signaling pathway_Homo sapiens_hsa040240.14870276
153Notch signaling pathway_Homo sapiens_hsa043300.14690121
154Calcium signaling pathway_Homo sapiens_hsa040200.14340307

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