IL17D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.61381567
2locomotory exploration behavior (GO:0035641)5.26705879
3synaptic vesicle maturation (GO:0016188)5.24233978
4sarcoplasmic reticulum calcium ion transport (GO:0070296)5.04266359
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.87570433
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73694797
7central nervous system myelination (GO:0022010)4.54245996
8axon ensheathment in central nervous system (GO:0032291)4.54245996
9layer formation in cerebral cortex (GO:0021819)4.41547141
10potassium ion import (GO:0010107)4.36257773
11vocalization behavior (GO:0071625)4.25190806
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.24933308
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22335550
14muscle filament sliding (GO:0030049)4.22076785
15actin-myosin filament sliding (GO:0033275)4.22076785
16synaptic vesicle exocytosis (GO:0016079)4.21349883
17L-amino acid import (GO:0043092)4.18660835
18glutamate secretion (GO:0014047)4.12941481
19positive regulation of synapse maturation (GO:0090129)4.12281630
20potassium ion homeostasis (GO:0055075)4.08582783
21positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.06452510
22exploration behavior (GO:0035640)3.93266790
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.91668828
24dendritic spine morphogenesis (GO:0060997)3.87367358
25regulation of synaptic vesicle exocytosis (GO:2000300)3.86169435
26regulation of glutamate receptor signaling pathway (GO:1900449)3.85454569
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.83395792
28regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.76813133
29amino acid import (GO:0043090)3.75051010
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.73525518
31neurotransmitter-gated ion channel clustering (GO:0072578)3.62917173
32positive regulation of dendritic spine development (GO:0060999)3.62754729
33regulation of cell communication by electrical coupling (GO:0010649)3.62744240
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58742637
35regulation of skeletal muscle contraction (GO:0014819)3.55066356
36regulation of synapse structural plasticity (GO:0051823)3.51376673
37creatine metabolic process (GO:0006600)3.49888275
38cellular sodium ion homeostasis (GO:0006883)3.48738655
39neurotransmitter uptake (GO:0001504)3.47905380
40presynaptic membrane organization (GO:0097090)3.43593751
41presynaptic membrane assembly (GO:0097105)3.42988903
42regulation of relaxation of muscle (GO:1901077)3.42073043
43striated muscle contraction (GO:0006941)3.41676837
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38663052
45actin-mediated cell contraction (GO:0070252)3.38285624
46skeletal muscle contraction (GO:0003009)3.38193289
47protein localization to synapse (GO:0035418)3.38021267
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37071763
49neurotransmitter secretion (GO:0007269)3.36693208
50cell communication by electrical coupling (GO:0010644)3.36231225
51activation of protein kinase A activity (GO:0034199)3.35372577
52regulation of neuronal synaptic plasticity (GO:0048168)3.34357583
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.33029031
54neuromuscular synaptic transmission (GO:0007274)3.32324930
55neuromuscular process controlling balance (GO:0050885)3.29794512
56regulation of voltage-gated calcium channel activity (GO:1901385)3.29406631
57cell migration in hindbrain (GO:0021535)3.29387766
58regulation of synaptic vesicle transport (GO:1902803)3.29007940
59regulation of actin filament-based movement (GO:1903115)3.27777846
60regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.26613665
61neuron cell-cell adhesion (GO:0007158)3.19260973
62neuronal ion channel clustering (GO:0045161)3.18894939
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16695987
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16217673
65skeletal muscle fiber development (GO:0048741)3.12945422
66cardiac muscle contraction (GO:0060048)3.10593930
67regulation of dendritic spine development (GO:0060998)3.10412728
68neuromuscular process controlling posture (GO:0050884)3.09913758
69membrane depolarization during action potential (GO:0086010)3.09890842
70regulation of neurotransmitter levels (GO:0001505)3.04483415
71regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.03979157
72neuronal action potential propagation (GO:0019227)2.96871416
73acidic amino acid transport (GO:0015800)2.96084004
74establishment of apical/basal cell polarity (GO:0035089)2.93577388
75axonal fasciculation (GO:0007413)2.93429920
76dendritic spine organization (GO:0097061)2.92683132
77response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.89561187
78proline transport (GO:0015824)2.89489219
79synaptic transmission, glutamatergic (GO:0035249)2.89329578
80regulation of female receptivity (GO:0045924)2.88673557
81dendrite morphogenesis (GO:0048813)2.87560383
82establishment of monopolar cell polarity (GO:0061162)2.87023692
83establishment or maintenance of monopolar cell polarity (GO:0061339)2.87023692
84regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86380750
85regulation of calcium ion transmembrane transport (GO:1903169)2.86380750
86establishment of mitochondrion localization (GO:0051654)2.83708640
87regulation of neurotransmitter transport (GO:0051588)2.81964231
88polarized epithelial cell differentiation (GO:0030859)2.81194107
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.79597594
90long-term memory (GO:0007616)2.79558138
91substantia nigra development (GO:0021762)2.78559613
92negative regulation of microtubule polymerization (GO:0031115)2.78351744
93ionotropic glutamate receptor signaling pathway (GO:0035235)2.77633468
94myofibril assembly (GO:0030239)2.77058670
95relaxation of muscle (GO:0090075)2.76193323
96regulation of membrane repolarization (GO:0060306)2.75712934
97negative regulation of catenin import into nucleus (GO:0035414)2.75598086
98positive regulation of potassium ion transport (GO:0043268)2.75573713
99neuron recognition (GO:0008038)2.75327582
100sodium ion export (GO:0071436)2.73951032
101cerebellar Purkinje cell layer development (GO:0021680)2.70969768
102regulation of dendritic spine morphogenesis (GO:0061001)2.69656363
103auditory behavior (GO:0031223)2.68134823
104regulation of synaptic plasticity (GO:0048167)2.67548689
105regulation of synapse maturation (GO:0090128)2.66798808
106synaptic vesicle endocytosis (GO:0048488)2.66414858
107cell-cell junction maintenance (GO:0045217)2.66012926
108regulation of early endosome to late endosome transport (GO:2000641)2.64888837
109neuromuscular process (GO:0050905)2.57398520
110response to pheromone (GO:0019236)2.57253758
111peptidyl-arginine omega-N-methylation (GO:0035247)2.56776490
112anterior/posterior axis specification, embryo (GO:0008595)2.56686052
113central nervous system projection neuron axonogenesis (GO:0021952)2.56397139
114innervation (GO:0060384)2.56145481
115growth hormone secretion (GO:0030252)2.55548455
116regulation of NFAT protein import into nucleus (GO:0051532)2.53575391
117cellular potassium ion homeostasis (GO:0030007)2.50681058
118cerebellum development (GO:0021549)2.49711396
119positive regulation of axon extension (GO:0045773)2.49178364
120negative regulation of potassium ion transmembrane transport (GO:1901380)2.47681768
121neuron-neuron synaptic transmission (GO:0007270)2.46100720
122positive regulation of membrane potential (GO:0045838)2.45987653
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.45859814
124regulation of posttranscriptional gene silencing (GO:0060147)2.44247267
125regulation of gene silencing by miRNA (GO:0060964)2.44247267
126regulation of gene silencing by RNA (GO:0060966)2.44247267
127histone arginine methylation (GO:0034969)2.43425882
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.42895780
129mitochondrion transport along microtubule (GO:0047497)2.42895780
130gamma-aminobutyric acid transport (GO:0015812)2.42884944
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.42560264
132negative regulation of cell size (GO:0045792)2.42533322
133neurotransmitter transport (GO:0006836)2.41481913
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41264412
135vesicle transport along microtubule (GO:0047496)2.41241700
136peptidyl-arginine methylation (GO:0018216)2.41139910
137peptidyl-arginine N-methylation (GO:0035246)2.41139910
138regulation of hippo signaling (GO:0035330)2.41097569
139cell junction maintenance (GO:0034331)2.39298701
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37828214
141glutamate receptor signaling pathway (GO:0007215)2.34445009
142membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34039312
143establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.33715742
144regulation of cAMP-dependent protein kinase activity (GO:2000479)2.32446024
145regulation of neurotransmitter secretion (GO:0046928)2.30270330
146regulation of postsynaptic membrane potential (GO:0060078)2.29997624
147establishment of nucleus localization (GO:0040023)2.29834775
148cerebellar granule cell differentiation (GO:0021707)2.29163241
149postsynaptic membrane organization (GO:0001941)2.28876635
150synapse organization (GO:0050808)2.28686611
151positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.28633875
152positive regulation of fibroblast migration (GO:0010763)2.28540592
153cell communication involved in cardiac conduction (GO:0086065)2.28199579
154organelle transport along microtubule (GO:0072384)2.28154751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.10524512
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92001475
3ZFP281_18757296_ChIP-ChIP_E14_Mouse2.74985126
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.56339222
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54849114
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.49896396
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.40946134
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24427601
9REST_21632747_ChIP-Seq_MESCs_Mouse2.19237838
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.18317228
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11415912
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11331167
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09422880
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04446413
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03431481
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03431481
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03362052
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01816282
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.99560231
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99152934
21KDM2B_26808549_Chip-Seq_K562_Human1.97726452
22ZNF263_19887448_ChIP-Seq_K562_Human1.93320497
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.93250320
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91893871
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90639599
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87481403
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.87259272
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85494812
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.79426754
30* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.78295286
31* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77740326
32DROSHA_22980978_ChIP-Seq_HELA_Human1.77270863
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76932897
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74897473
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73587265
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71248326
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.70577522
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.70577522
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.70577522
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67584737
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67368651
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66724979
43LXR_22292898_ChIP-Seq_THP-1_Human1.63140535
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62639161
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56113271
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.54296020
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.51955099
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51495631
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51423786
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50309251
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50060695
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46188895
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.45854808
54SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44473731
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43991917
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43065973
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41297698
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41180665
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40893007
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.36816198
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35186872
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34959141
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.33572916
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31528683
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29409139
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29191897
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29047718
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28386229
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26172622
70* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25557302
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.23822518
72KDM2B_26808549_Chip-Seq_DND41_Human1.23694258
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.21363087
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.20885701
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20522451
76* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19400814
77* CTCF_27219007_Chip-Seq_Bcells_Human1.17209664
78SMC4_20622854_ChIP-Seq_HELA_Human1.16907593
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13699626
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12921280
81ZNF274_21170338_ChIP-Seq_K562_Hela1.12850458
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12347848
83PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09459235
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07839631
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07280005
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07144367
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07014416
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.06628360
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05910321
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05766052
91RNF2_27304074_Chip-Seq_NSC_Mouse1.03816565
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03705450
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.02915119
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01537201
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01164768
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00625063
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00335274
98TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98538974
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97855222
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96884149
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96883708
102RACK7_27058665_Chip-Seq_MCF-7_Human0.96819987
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.96806919
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96465897
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.96337300
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95912297
107OCT4_19829295_ChIP-Seq_ESCs_Human0.95877693
108* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94860251
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94412629
110SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94229721
111GBX2_23144817_ChIP-Seq_PC3_Human0.92504078
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.91670997
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90967897
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90066109
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89965048
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.89466675
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89244777
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88649098
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.88420232
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.88420232
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.87999547
122AR_19668381_ChIP-Seq_PC3_Human0.87711507
123AR_21572438_ChIP-Seq_LNCaP_Human0.86932454
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86638879
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85092492
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80347421
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77588024
128MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.77068166
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75840601
130KLF4_19829295_ChIP-Seq_ESCs_Human0.75401324
131* MYC_27129775_Chip-Seq_CORNEA_Mouse0.74384357
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73870674
133NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73492385
134SOX9_26525672_Chip-Seq_HEART_Mouse0.72652051
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.71904511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25426480
2MP0003283_abnormal_digestive_organ3.23507888
3MP0003635_abnormal_synaptic_transmissio2.96645664
4MP0004270_analgesia2.86171062
5MP0000749_muscle_degeneration2.68757637
6MP0003646_muscle_fatigue2.51238072
7MP0002063_abnormal_learning/memory/cond2.34011704
8MP0003880_abnormal_central_pattern2.32178031
9MP0004858_abnormal_nervous_system2.14034340
10MP0002909_abnormal_adrenal_gland2.04984542
11MP0003123_paternal_imprinting1.96118414
12MP0009780_abnormal_chondrocyte_physiolo1.94644300
13MP0004233_abnormal_muscle_weight1.92079956
14MP0005623_abnormal_meninges_morphology1.92017732
15MP0003119_abnormal_digestive_system1.91246066
16MP0002653_abnormal_ependyma_morphology1.88843191
17MP0005423_abnormal_somatic_nervous1.86320993
18MP0004130_abnormal_muscle_cell1.83520339
19MP0002064_seizures1.81956981
20MP0004036_abnormal_muscle_relaxation1.79716911
21MP0003690_abnormal_glial_cell1.79313449
22MP0009745_abnormal_behavioral_response1.76501996
23MP0002572_abnormal_emotion/affect_behav1.75267682
24MP0000537_abnormal_urethra_morphology1.70360274
25MP0003122_maternal_imprinting1.69594016
26MP0002734_abnormal_mechanical_nocicepti1.67672587
27MP0009046_muscle_twitch1.65834639
28MP0002736_abnormal_nociception_after1.64849998
29MP0000751_myopathy1.63328189
30MP0002735_abnormal_chemical_nociception1.61905241
31MP0000778_abnormal_nervous_system1.61371299
32MP0002106_abnormal_muscle_physiology1.60938346
33MP0003705_abnormal_hypodermis_morpholog1.57905501
34MP0004811_abnormal_neuron_physiology1.56424747
35MP0002822_catalepsy1.56424352
36MP0000759_abnormal_skeletal_muscle1.55969546
37MP0005646_abnormal_pituitary_gland1.54875351
38MP0002184_abnormal_innervation1.53504069
39MP0000955_abnormal_spinal_cord1.49729888
40MP0004087_abnormal_muscle_fiber1.49494756
41MP0001502_abnormal_circadian_rhythm1.46937468
42MP0002837_dystrophic_cardiac_calcinosis1.46577262
43MP0000920_abnormal_myelination1.42277101
44MP0000013_abnormal_adipose_tissue1.41508132
45MP0002272_abnormal_nervous_system1.37306520
46MP0005369_muscle_phenotype1.36170552
47MP0004133_heterotaxia1.34469065
48MP0003633_abnormal_nervous_system1.34444926
49MP0002733_abnormal_thermal_nociception1.31238327
50MP0005620_abnormal_muscle_contractility1.29817536
51MP0008961_abnormal_basal_metabolism1.26897698
52MP0000534_abnormal_ureter_morphology1.26773566
53MP0006276_abnormal_autonomic_nervous1.26436742
54MP0010030_abnormal_orbit_morphology1.25972849
55MP0005167_abnormal_blood-brain_barrier1.25000489
56MP0001486_abnormal_startle_reflex1.24682571
57MP0001968_abnormal_touch/_nociception1.23133019
58MP0003634_abnormal_glial_cell1.19673129
59MP0002152_abnormal_brain_morphology1.16320043
60MP0002332_abnormal_exercise_endurance1.16032014
61MP0001970_abnormal_pain_threshold1.15742870
62MP0003861_abnormal_nervous_system1.15151197
63MP0000750_abnormal_muscle_regeneration1.14493003
64MP0001299_abnormal_eye_distance/1.13209390
65MP0004145_abnormal_muscle_electrophysio1.13190152
66MP0002882_abnormal_neuron_morphology1.12556975
67MP0003631_nervous_system_phenotype1.11527732
68MP0004215_abnormal_myocardial_fiber1.10674600
69MP0003787_abnormal_imprinting1.10116019
70MP0001905_abnormal_dopamine_level1.08417738
71MP0002557_abnormal_social/conspecific_i1.08188869
72MP0008569_lethality_at_weaning1.06743172
73MP0001529_abnormal_vocalization1.06726179
74MP0003136_yellow_coat_color1.06295990
75MP0001346_abnormal_lacrimal_gland1.05929552
76MP0000003_abnormal_adipose_tissue1.05592828
77MP0001348_abnormal_lacrimal_gland1.03142420
78MP0002089_abnormal_postnatal_growth/wei1.02738474
79MP0001984_abnormal_olfaction1.01175178
80MP0002066_abnormal_motor_capabilities/c1.00028690
81MP0005076_abnormal_cell_differentiation0.99660930
82MP0001440_abnormal_grooming_behavior0.98812160
83MP0004924_abnormal_behavior0.97671766
84MP0005386_behavior/neurological_phenoty0.97671766
85MP0001963_abnormal_hearing_physiology0.97202970
86MP0004885_abnormal_endolymph0.96160692
87MP0010352_gastrointestinal_tract_polyps0.95329388
88MP0003121_genomic_imprinting0.94934021
89MP0000516_abnormal_urinary_system0.93614424
90MP0005367_renal/urinary_system_phenotyp0.93614424
91MP0003942_abnormal_urinary_system0.93055778
92MP0002234_abnormal_pharynx_morphology0.91799230
93MP0003329_amyloid_beta_deposits0.91695004
94MP0002067_abnormal_sensory_capabilities0.91588630
95MP0004142_abnormal_muscle_tone0.91529640
96MP0005171_absent_coat_pigmentation0.91232886
97MP0000631_abnormal_neuroendocrine_gland0.91185976
98MP0000579_abnormal_nail_morphology0.91065284
99MP0000733_abnormal_muscle_development0.90990771
100MP0003385_abnormal_body_wall0.90884012
101MP0002972_abnormal_cardiac_muscle0.90239998
102MP0001177_atelectasis0.90112286
103MP0000462_abnormal_digestive_system0.89843290
104MP0003890_abnormal_embryonic-extraembry0.89537170
105MP0002084_abnormal_developmental_patter0.89522829
106MP0004084_abnormal_cardiac_muscle0.89405777
107MP0003137_abnormal_impulse_conducting0.89244469
108MP0002229_neurodegeneration0.89215701
109MP0003879_abnormal_hair_cell0.88273133
110MP0008438_abnormal_cutaneous_collagen0.87681889
111MP0000049_abnormal_middle_ear0.87633898
112MP0001485_abnormal_pinna_reflex0.87144548
113MP0002116_abnormal_craniofacial_bone0.85484283
114MP0002638_abnormal_pupillary_reflex0.85336784
115MP0003632_abnormal_nervous_system0.84475913
116MP0005187_abnormal_penis_morphology0.84335801
117MP0002282_abnormal_trachea_morphology0.84194710
118MP0005330_cardiomyopathy0.83586690
119MP0000428_abnormal_craniofacial_morphol0.83322941
120MP0002249_abnormal_larynx_morphology0.83294689
121MP0009379_abnormal_foot_pigmentation0.82287452
122MP0005409_darkened_coat_color0.81680079
123MP0005257_abnormal_intraocular_pressure0.81238590
124MP0002269_muscular_atrophy0.81156326
125MP0003755_abnormal_palate_morphology0.80896402
126MP0003935_abnormal_craniofacial_develop0.80454266
127MP0000678_abnormal_parathyroid_gland0.79823809
128MP0005499_abnormal_olfactory_system0.78593295
129MP0005394_taste/olfaction_phenotype0.78593295
130MP0000747_muscle_weakness0.77884739
131MP0002085_abnormal_embryonic_tissue0.76429359
132MP0001501_abnormal_sleep_pattern0.76202445
133MP0006036_abnormal_mitochondrial_physio0.74807784
134MP0002081_perinatal_lethality0.74792321
135MP0004197_abnormal_fetal_growth/weight/0.74655030
136MP0002108_abnormal_muscle_morphology0.74268006
137MP0001849_ear_inflammation0.73642925
138MP0004085_abnormal_heartbeat0.73259919
139MP0002896_abnormal_bone_mineralization0.73074862
140MP0006072_abnormal_retinal_apoptosis0.72616313
141MP0002114_abnormal_axial_skeleton0.72453869
142MP0004742_abnormal_vestibular_system0.72449793
143MP0005503_abnormal_tendon_morphology0.72179434
144MP0010234_abnormal_vibrissa_follicle0.72046010
145MP0001943_abnormal_respiration0.71130937
146MP0000026_abnormal_inner_ear0.70094008
147MP0005551_abnormal_eye_electrophysiolog0.69887067
148MP0004484_altered_response_of0.69090566
149MP0002752_abnormal_somatic_nervous0.68582763
150MP0008874_decreased_physiological_sensi0.61346940
151MP0004147_increased_porphyrin_level0.61217672

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.87955778
2Muscle fiber inclusion bodies (HP:0100299)6.84727796
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.63491442
4Type 1 muscle fiber predominance (HP:0003803)5.32094258
5Exercise-induced myalgia (HP:0003738)5.10125356
6Exercise-induced muscle cramps (HP:0003710)5.03493058
7Myokymia (HP:0002411)4.18340820
8Myopathic facies (HP:0002058)3.94881524
9Muscle hypertrophy of the lower extremities (HP:0008968)3.76603325
10Hyporeflexia of lower limbs (HP:0002600)3.76130587
11EMG: myopathic abnormalities (HP:0003458)3.68608022
12Distal arthrogryposis (HP:0005684)3.54741469
13Muscle fiber splitting (HP:0003555)3.52769028
14Abnormality of the left ventricular outflow tract (HP:0011103)3.39718207
15Subaortic stenosis (HP:0001682)3.39718207
16Visual hallucinations (HP:0002367)3.39644409
17Calf muscle hypertrophy (HP:0008981)3.34600008
18Abnormality of the lower motor neuron (HP:0002366)3.27458287
19Focal motor seizures (HP:0011153)3.13995268
20Centrally nucleated skeletal muscle fibers (HP:0003687)3.11150839
21Diplopia (HP:0000651)3.10649580
22Abnormality of binocular vision (HP:0011514)3.10649580
23Round ear (HP:0100830)3.06470601
24Myotonia (HP:0002486)2.98128388
25Focal seizures (HP:0007359)2.86743720
26Difficulty running (HP:0009046)2.82584780
27Abnormality of the calf musculature (HP:0001430)2.81010141
28Rhabdomyolysis (HP:0003201)2.79566598
29Myoglobinuria (HP:0002913)2.78396647
30Neurofibrillary tangles (HP:0002185)2.78095504
31Frequent falls (HP:0002359)2.74501746
32Fetal akinesia sequence (HP:0001989)2.69639926
33Abnormality of skeletal muscle fiber size (HP:0012084)2.69202745
34Muscle stiffness (HP:0003552)2.69050899
35Neck muscle weakness (HP:0000467)2.66748089
36EMG: neuropathic changes (HP:0003445)2.63256593
37Astrocytoma (HP:0009592)2.61503842
38Abnormality of the astrocytes (HP:0100707)2.61503842
39Calcaneovalgus deformity (HP:0001848)2.52707239
40Epileptic encephalopathy (HP:0200134)2.52436854
41Abnormality of the foot musculature (HP:0001436)2.50294640
42Ependymoma (HP:0002888)2.49909538
43Annular pancreas (HP:0001734)2.48578505
44Rimmed vacuoles (HP:0003805)2.48210612
45Ankle clonus (HP:0011448)2.44816043
46Heart block (HP:0012722)2.43906522
47Foot dorsiflexor weakness (HP:0009027)2.42849854
48Tetraplegia (HP:0002445)2.41421380
49Ventricular fibrillation (HP:0001663)2.40215755
50Shallow orbits (HP:0000586)2.39844178
51Neoplasm of the heart (HP:0100544)2.33745877
52Peripheral hypomyelination (HP:0007182)2.33261367
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33100278
54Increased variability in muscle fiber diameter (HP:0003557)2.31952958
55Ulnar deviation of the wrist (HP:0003049)2.31631722
56Dysmetria (HP:0001310)2.31157260
57Absent phalangeal crease (HP:0006109)2.29109909
58Distal lower limb muscle weakness (HP:0009053)2.28240529
59Abnormal eating behavior (HP:0100738)2.27347880
60Cerebral inclusion bodies (HP:0100314)2.27178710
61Cerebral hypomyelination (HP:0006808)2.27052237
62Action tremor (HP:0002345)2.24745612
63Atonic seizures (HP:0010819)2.24593613
64Achilles tendon contracture (HP:0001771)2.24371218
65Limb dystonia (HP:0002451)2.23941718
66Abnormal atrioventricular conduction (HP:0005150)2.23531495
67Genu recurvatum (HP:0002816)2.21127757
68Bronchomalacia (HP:0002780)2.20913720
69Akinesia (HP:0002304)2.19066216
70Lower limb amyotrophy (HP:0007210)2.17455483
71Hand muscle atrophy (HP:0009130)2.17147802
72Obstructive sleep apnea (HP:0002870)2.16822704
73Truncal ataxia (HP:0002078)2.16545161
74Hypercortisolism (HP:0001578)2.16231180
75Deformed tarsal bones (HP:0008119)2.16118623
76Distal upper limb amyotrophy (HP:0007149)2.13100127
77Upper limb amyotrophy (HP:0009129)2.13100127
78Hypoplastic ischia (HP:0003175)2.12527186
79Intention tremor (HP:0002080)2.11055465
80Genetic anticipation (HP:0003743)2.10361205
81Renal duplication (HP:0000075)2.09895599
82Protrusio acetabuli (HP:0003179)2.09123261
83Insomnia (HP:0100785)2.07338268
84Amyotrophic lateral sclerosis (HP:0007354)2.06872579
85Supranuclear gaze palsy (HP:0000605)2.06239783
86Hyperacusis (HP:0010780)2.04684663
87Areflexia of lower limbs (HP:0002522)2.04167860
88Impaired vibration sensation in the lower limbs (HP:0002166)2.01446987
89Urinary urgency (HP:0000012)1.99905366
90Pointed chin (HP:0000307)1.99904769
91Epiphyseal dysplasia (HP:0002656)1.99254452
92Progressive cerebellar ataxia (HP:0002073)1.97927368
93Depression (HP:0000716)1.97691434
94Bundle branch block (HP:0011710)1.97533936
95Rapidly progressive (HP:0003678)1.97399779
96Turricephaly (HP:0000262)1.96721609
97Absence seizures (HP:0002121)1.96663936
98Abnormality of the labia minora (HP:0012880)1.96055999
99Dysdiadochokinesis (HP:0002075)1.95589082
100Rigidity (HP:0002063)1.94161638
101Amblyopia (HP:0000646)1.93307915
102Increased connective tissue (HP:0009025)1.91841773
103Lower limb muscle weakness (HP:0007340)1.91061733
104Sleep apnea (HP:0010535)1.86896942
105Termporal pattern (HP:0011008)1.86518979
106Insidious onset (HP:0003587)1.86518979
107Anxiety (HP:0000739)1.86440976
108Urinary bladder sphincter dysfunction (HP:0002839)1.85750161
109Abnormality of the Achilles tendon (HP:0005109)1.84977022
110Delusions (HP:0000746)1.84939985
111Hemiparesis (HP:0001269)1.83924454
112Ankyloglossia (HP:0010296)1.83596251
113Abnormal finger flexion creases (HP:0006143)1.81128225
114Poor eye contact (HP:0000817)1.80812622
115Status epilepticus (HP:0002133)1.78073562
116Bowel diverticulosis (HP:0005222)1.77044460
117Hepatoblastoma (HP:0002884)1.77037529
118Abnormal social behavior (HP:0012433)1.76800767
119Impaired social interactions (HP:0000735)1.76800767
120Asymmetric septal hypertrophy (HP:0001670)1.76292238
121Abnormality of the ischium (HP:0003174)1.76134837
122Cerebral aneurysm (HP:0004944)1.75186638
123Resting tremor (HP:0002322)1.74607028
124Scanning speech (HP:0002168)1.74319981
125Incomplete penetrance (HP:0003829)1.74193024
126Rib fusion (HP:0000902)1.73013120
127Mild short stature (HP:0003502)1.72366088
128Bladder diverticulum (HP:0000015)1.72151937
129Increased circulating renin level (HP:0000848)1.70812382
130Dialeptic seizures (HP:0011146)1.69968627
131Generalized tonic-clonic seizures (HP:0002069)1.69730266
132Mildly elevated creatine phosphokinase (HP:0008180)1.69687798
133Torticollis (HP:0000473)1.68559093
134Glioma (HP:0009733)1.68270192
135Difficulty climbing stairs (HP:0003551)1.68149554
136Megalencephaly (HP:0001355)1.66973829
137Overgrowth (HP:0001548)1.64593196
138Broad-based gait (HP:0002136)1.62335280
139Hyperextensible skin (HP:0000974)1.62262693
140Overriding aorta (HP:0002623)1.59655890
141Hypoventilation (HP:0002791)1.58066922
142Papilledema (HP:0001085)1.57332499
143Angiofibromas (HP:0010615)1.56230103
144Adenoma sebaceum (HP:0009720)1.56230103
145Spinal cord compression (HP:0002176)1.55886796
146Febrile seizures (HP:0002373)1.55356908
147Abnormality of the pubic bones (HP:0003172)1.54710242
148Thin ribs (HP:0000883)1.53408614
149Sudden death (HP:0001699)1.53220440
150Shawl scrotum (HP:0000049)1.52520793
151Shoulder girdle muscle weakness (HP:0003547)1.52017132
152Impaired smooth pursuit (HP:0007772)1.51681193
153Macroorchidism (HP:0000053)1.51315741
154Postural instability (HP:0002172)1.49158062
155Missing ribs (HP:0000921)1.49121959
156Ulnar bowing (HP:0003031)1.48023892
157Abnormality of the aortic arch (HP:0012303)1.47993429
158Ankle contracture (HP:0006466)1.46640489
159Failure to thrive in infancy (HP:0001531)1.46170828
160Spastic gait (HP:0002064)1.45851742
161Elfin facies (HP:0004428)1.45404095
162Short humerus (HP:0005792)1.45247089
163Hemiplegia (HP:0002301)1.45046912
164Abnormal EKG (HP:0003115)1.44906326
165Flat cornea (HP:0007720)1.44187964
166Abnormality of the corticospinal tract (HP:0002492)1.44176238
167Testicular atrophy (HP:0000029)1.43837335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.66770970
2PRKD33.92045845
3MAP3K93.39304456
4MARK13.16312564
5DDR22.75617315
6TYRO32.70795362
7NTRK32.47322952
8EPHA42.36759353
9TRIB32.34853926
10PAK62.29474716
11LATS22.24398170
12DAPK22.18263008
13ICK2.14026272
14MINK11.95782755
15TAOK11.91072027
16KSR21.83822497
17ARAF1.83105917
18MAP3K41.81430411
19NTRK11.76295703
20DAPK11.69886117
21PHKG21.65273114
22PHKG11.65273114
23KSR11.64712537
24INSRR1.59263911
25MAPK121.56202593
26MAP3K21.53625215
27PDGFRA1.51133452
28NTRK21.47765786
29STK381.47527093
30UHMK11.45329688
31CAMK2G1.44034304
32CAMKK11.25103626
33SGK2231.24363647
34SGK4941.24363647
35CDK121.19255143
36ALK1.18882805
37PRPF4B1.17210978
38RIPK11.17089694
39GRK51.14311913
40CDK51.14043410
41PKN11.12315307
42PDK31.10180360
43PDK41.10180360
44SGK21.09941453
45PKN21.08938120
46MAP2K41.06581457
47PRKD21.06267269
48SGK31.01213757
49SCYL20.99703878
50CAMK2D0.99066017
51MARK20.95183243
52PAK30.95082550
53STK110.91296667
54DYRK1B0.88931884
55CDK140.88403319
56CDK150.86488683
57NEK10.85990170
58CDK180.82894302
59SGK10.80208363
60CASK0.79572821
61NEK60.78442079
62DYRK20.78277317
63BMX0.77867312
64CDK11A0.77302036
65CDC42BPA0.77110322
66MAP3K60.76888556
67DMPK0.76734697
68PRKCG0.76081734
69MAP3K130.75632050
70NME10.74268187
71EPHA20.73554869
72CDK190.73117939
73MAP2K70.70659435
74AKT30.70356552
75DAPK30.69782584
76RET0.69448968
77PTK20.67472904
78LMTK20.67011904
79MOS0.66774671
80PNCK0.65576669
81BRAF0.65353169
82LIMK10.62788847
83MAPK130.62443427
84EPHB20.61755975
85ROCK20.61661584
86PRKCI0.59744768
87RAF10.59627515
88ROCK10.59527215
89PINK10.58824977
90MAP2K10.55647139
91MTOR0.54367449
92PLK20.54312985
93STK38L0.53981335
94MAP3K100.53926604
95TESK10.53753990
96TNK20.52294397
97CCNB10.51637555
98TNIK0.51048047
99AKT20.51014675
100MUSK0.50799704
101PRKG10.50532775
102PDK20.50138226
103CAMK2A0.49876565
104PRKCH0.49089731
105RPS6KA20.47204925
106CAMK10.46934202
107CAMK40.45695015
108MAPK100.45489577
109MAPKAPK30.45269941
110DYRK1A0.44578417
111PRKCZ0.43797552
112MAP3K110.43763780
113RPS6KB10.43578567
114FER0.42963600
115MAPK40.40582079
116PDPK10.40515723
117CSNK1G20.40118905
118CSNK1E0.39193093
119MAP3K70.39071953
120RPS6KA30.37651019
121ILK0.36097735
122PDK10.36049490
123RPS6KA10.35584965
124FGFR20.35401231
125PRKD10.34796774
126TTN0.34736162
127WNK30.34684962
128PRKG20.34515149
129MAP2K60.34282685
130PAK20.33632460
131SIK20.33554504
132PRKACA0.33489947
133CAMK2B0.33267815
134PRKAA10.33246622
135FES0.30983430
136BRSK10.29567647
137CSNK1D0.29321609

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.59000041
2Synaptic vesicle cycle_Homo sapiens_hsa047212.55189088
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46659384
4Long-term potentiation_Homo sapiens_hsa047202.25080758
5Amphetamine addiction_Homo sapiens_hsa050312.05893654
6Circadian entrainment_Homo sapiens_hsa047132.03295470
7Nicotine addiction_Homo sapiens_hsa050331.99320114
8Insulin secretion_Homo sapiens_hsa049111.93435323
9Dopaminergic synapse_Homo sapiens_hsa047281.88790917
10Glutamatergic synapse_Homo sapiens_hsa047241.87397289
11GABAergic synapse_Homo sapiens_hsa047271.86563018
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78024510
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71173006
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65999626
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65814331
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65265187
17Salivary secretion_Homo sapiens_hsa049701.64738049
18Gap junction_Homo sapiens_hsa045401.61594681
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59893326
20Morphine addiction_Homo sapiens_hsa050321.58156873
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55114652
22Gastric acid secretion_Homo sapiens_hsa049711.53249389
23GnRH signaling pathway_Homo sapiens_hsa049121.52929105
24Cholinergic synapse_Homo sapiens_hsa047251.50918005
25Oxytocin signaling pathway_Homo sapiens_hsa049211.50023256
26mTOR signaling pathway_Homo sapiens_hsa041501.48748570
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48111866
28Hedgehog signaling pathway_Homo sapiens_hsa043401.43553396
29Oocyte meiosis_Homo sapiens_hsa041141.43375341
30Melanogenesis_Homo sapiens_hsa049161.43164386
31Estrogen signaling pathway_Homo sapiens_hsa049151.42159087
32Arginine and proline metabolism_Homo sapiens_hsa003301.40865198
33Long-term depression_Homo sapiens_hsa047301.38255326
34Cocaine addiction_Homo sapiens_hsa050301.37758902
35Glioma_Homo sapiens_hsa052141.37109633
36Hippo signaling pathway_Homo sapiens_hsa043901.33924669
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.28762510
38Axon guidance_Homo sapiens_hsa043601.27186248
39Renin secretion_Homo sapiens_hsa049241.24547089
40Circadian rhythm_Homo sapiens_hsa047101.20970980
41ErbB signaling pathway_Homo sapiens_hsa040121.20660917
42Dilated cardiomyopathy_Homo sapiens_hsa054141.13228734
43Type II diabetes mellitus_Homo sapiens_hsa049301.12377933
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11710620
45Basal cell carcinoma_Homo sapiens_hsa052171.09942375
46Vitamin B6 metabolism_Homo sapiens_hsa007501.09138323
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08407961
48Taste transduction_Homo sapiens_hsa047421.06296045
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04223653
50Cardiac muscle contraction_Homo sapiens_hsa042601.02794537
51Wnt signaling pathway_Homo sapiens_hsa043101.02468803
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02232170
53Calcium signaling pathway_Homo sapiens_hsa040201.01090777
54Arginine biosynthesis_Homo sapiens_hsa002201.00109527
55cAMP signaling pathway_Homo sapiens_hsa040240.99807583
56VEGF signaling pathway_Homo sapiens_hsa043700.98894078
57Dorso-ventral axis formation_Homo sapiens_hsa043200.97746368
58Bile secretion_Homo sapiens_hsa049760.97650028
59Tight junction_Homo sapiens_hsa045300.97329587
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96899431
61Bladder cancer_Homo sapiens_hsa052190.96498923
62Glucagon signaling pathway_Homo sapiens_hsa049220.95437428
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94974105
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94202865
65Serotonergic synapse_Homo sapiens_hsa047260.92835185
66Vibrio cholerae infection_Homo sapiens_hsa051100.89920878
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89889185
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.89203030
69Thyroid hormone synthesis_Homo sapiens_hsa049180.87348883
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86877701
71Insulin signaling pathway_Homo sapiens_hsa049100.86163940
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85450293
73Endometrial cancer_Homo sapiens_hsa052130.85293938
74Alzheimers disease_Homo sapiens_hsa050100.84779172
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84706914
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.84652694
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81965570
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.80110548
79Rap1 signaling pathway_Homo sapiens_hsa040150.79125007
80Focal adhesion_Homo sapiens_hsa045100.78379829
81mRNA surveillance pathway_Homo sapiens_hsa030150.77619600
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76769667
83Choline metabolism in cancer_Homo sapiens_hsa052310.76219858
84MAPK signaling pathway_Homo sapiens_hsa040100.76138050
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75578346
86Colorectal cancer_Homo sapiens_hsa052100.74380726
87beta-Alanine metabolism_Homo sapiens_hsa004100.73246306
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.72853464
89Renal cell carcinoma_Homo sapiens_hsa052110.71334315
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70139394
91Proteoglycans in cancer_Homo sapiens_hsa052050.70085174
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67717867
93Protein digestion and absorption_Homo sapiens_hsa049740.67351319
94Non-small cell lung cancer_Homo sapiens_hsa052230.66993335
95AMPK signaling pathway_Homo sapiens_hsa041520.66508999
96Inositol phosphate metabolism_Homo sapiens_hsa005620.65457407
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64456569
98Endocytosis_Homo sapiens_hsa041440.64134943
99ECM-receptor interaction_Homo sapiens_hsa045120.62429631
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60682471
101Thyroid cancer_Homo sapiens_hsa052160.59566588
102Alcoholism_Homo sapiens_hsa050340.58101585
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57962505
104Prion diseases_Homo sapiens_hsa050200.56883951
105Carbon metabolism_Homo sapiens_hsa012000.56100833
106Ras signaling pathway_Homo sapiens_hsa040140.55599602
107Pancreatic secretion_Homo sapiens_hsa049720.54117333
108Melanoma_Homo sapiens_hsa052180.51855630
109TGF-beta signaling pathway_Homo sapiens_hsa043500.51277906
110Collecting duct acid secretion_Homo sapiens_hsa049660.50943413
111Histidine metabolism_Homo sapiens_hsa003400.50840184
112Parkinsons disease_Homo sapiens_hsa050120.48631658
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47859044
114Nitrogen metabolism_Homo sapiens_hsa009100.46893369
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.46228136
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45885002
117Adherens junction_Homo sapiens_hsa045200.45855208
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44616194
119Phototransduction_Homo sapiens_hsa047440.43970465
120Sulfur relay system_Homo sapiens_hsa041220.42982658
121Pyruvate metabolism_Homo sapiens_hsa006200.41605386
122Oxidative phosphorylation_Homo sapiens_hsa001900.40515003
123Biosynthesis of amino acids_Homo sapiens_hsa012300.39399968
124Fatty acid metabolism_Homo sapiens_hsa012120.32842027

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