IL17F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of immunoglobulin secretion (GO:0051023)7.46199282
2tyrosine phosphorylation of STAT protein (GO:0007260)7.42530250
3regulation of interleukin-12 biosynthetic process (GO:0045075)7.27146362
4response to interleukin-15 (GO:0070672)7.02302502
5alpha-beta T cell differentiation (GO:0046632)6.85189334
6positive regulation of natural killer cell differentiation (GO:0032825)6.73157591
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.62995624
8cellular response to interleukin-15 (GO:0071350)5.84620013
9positive regulation of interleukin-17 production (GO:0032740)5.75815915
10alpha-beta T cell activation (GO:0046631)5.69342911
11negative regulation of thymocyte apoptotic process (GO:0070244)5.66511885
12myeloid dendritic cell differentiation (GO:0043011)5.54444829
13positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)5.49549461
14regulation of memory T cell differentiation (GO:0043380)5.42406837
15positive regulation of cell fate commitment (GO:0010455)5.22850281
16positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.11999051
17tolerance induction (GO:0002507)5.04740183
18positive regulation of gamma-delta T cell activation (GO:0046645)5.03145817
19* regulation of interleukin-2 biosynthetic process (GO:0045076)4.97945553
20mast cell degranulation (GO:0043303)4.97578520
21mast cell activation involved in immune response (GO:0002279)4.97578520
22positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.92914211
23regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.92914211
24regulation of T-helper 1 cell differentiation (GO:0045625)4.82063096
25DNA double-strand break processing (GO:0000729)4.81772933
26leukocyte aggregation (GO:0070486)4.81240380
27regulation of vitamin D biosynthetic process (GO:0060556)4.79454652
28regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.78920731
29positive regulation of activated T cell proliferation (GO:0042104)4.70525748
30positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.66518795
31positive regulation of interleukin-2 production (GO:0032743)4.61290662
32valine metabolic process (GO:0006573)4.54304294
33T cell apoptotic process (GO:0070231)4.54237984
34myeloid dendritic cell activation (GO:0001773)4.53429799
35positive regulation of natural killer cell mediated immunity (GO:0002717)4.44015598
36positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.44015598
37lymphocyte apoptotic process (GO:0070227)4.42045350
38leukocyte apoptotic process (GO:0071887)4.41168941
39negative T cell selection (GO:0043383)4.39394734
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.33237500
41* regulation of interleukin-6 biosynthetic process (GO:0045408)4.33064776
42regulation of natural killer cell differentiation (GO:0032823)4.27643074
43acute-phase response (GO:0006953)4.12314107
44somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.08156016
45somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.08156016
46isotype switching (GO:0045190)4.08156016
47positive regulation of T cell cytokine production (GO:0002726)4.08103768
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.02659757
49activated T cell proliferation (GO:0050798)3.99996053
50* regulation of cytokine production involved in inflammatory response (GO:1900015)3.97915905
51regulation of gamma-delta T cell activation (GO:0046643)3.96869717
52positive regulation of transcription regulatory region DNA binding (GO:2000679)3.96350319
53positive regulation of defense response to virus by host (GO:0002230)3.93937885
54regulation of gamma-delta T cell differentiation (GO:0045586)3.90992187
55autophagic vacuole fusion (GO:0000046)3.90390717
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.89431771
57mast cell activation (GO:0045576)3.83711955
58regulation of T-helper cell differentiation (GO:0045622)3.83006154
59negative thymic T cell selection (GO:0045060)3.81478029
60regulation of natural killer cell mediated immunity (GO:0002715)3.79318405
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.79318405
62positive regulation of osteoclast differentiation (GO:0045672)3.76557292
63regulation of regulatory T cell differentiation (GO:0045589)3.73683227
64regulation of vitamin metabolic process (GO:0030656)3.73199613
65positive regulation of humoral immune response (GO:0002922)3.72688401
66inflammatory response to antigenic stimulus (GO:0002437)3.66902448
67Peyers patch development (GO:0048541)3.66591765
68mucosal-associated lymphoid tissue development (GO:0048537)3.66591765
69positive regulation of astrocyte differentiation (GO:0048711)3.64657027
70positive regulation of lymphocyte mediated immunity (GO:0002708)3.59955030
71T cell differentiation (GO:0030217)3.57286025
72regulation of thymocyte apoptotic process (GO:0070243)3.57194931
73positive regulation of cell killing (GO:0031343)3.52065534
74T-helper 1 type immune response (GO:0042088)3.51840673
75positive regulation of macrophage differentiation (GO:0045651)3.49954218
76* regulation of interleukin-2 production (GO:0032663)3.47644219
77negative regulation of T-helper cell differentiation (GO:0045623)3.43816261
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.43816261
79DNA deamination (GO:0045006)3.43217305
80regulation of T-helper 1 type immune response (GO:0002825)3.39759508
81regulation of activated T cell proliferation (GO:0046006)3.37389228
82ether lipid metabolic process (GO:0046485)3.36732177
83regulation of interleukin-17 production (GO:0032660)3.34429249
84regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33737698
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.32366450
86T-helper cell differentiation (GO:0042093)3.32366450
87organelle membrane fusion (GO:0090174)3.31284985
88pyrimidine ribonucleoside catabolic process (GO:0046133)3.30823979
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.29812675
90regulation of glycogen (starch) synthase activity (GO:2000465)3.28885411
91cytidine metabolic process (GO:0046087)3.28885099
92cytidine catabolic process (GO:0006216)3.28885099
93cytidine deamination (GO:0009972)3.28885099
94signal peptide processing (GO:0006465)3.27721722
95positive regulation of myeloid leukocyte differentiation (GO:0002763)3.27572319
96natural killer cell activation involved in immune response (GO:0002323)3.26720077
97positive regulation of interleukin-12 production (GO:0032735)3.24892723
98regulation of chronic inflammatory response (GO:0002676)3.23615451
99interferon-gamma production (GO:0032609)3.23441298
100regulation of leukocyte mediated cytotoxicity (GO:0001910)3.22315447
101non-recombinational repair (GO:0000726)3.21358901
102double-strand break repair via nonhomologous end joining (GO:0006303)3.21358901
103positive regulation of T cell mediated immunity (GO:0002711)3.19034393
104regulation of response to interferon-gamma (GO:0060330)3.18459276
105positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17567810
106T cell selection (GO:0045058)3.17050343
107positive regulation of interferon-gamma production (GO:0032729)3.15828562
108negative regulation of metanephros development (GO:0072217)3.15414126
109positive regulation of natural killer cell activation (GO:0032816)3.14904571
110regulation of T cell cytokine production (GO:0002724)3.14676583
111regulation of immunoglobulin production (GO:0002637)3.14629445
112regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.14490364
113CD4-positive, alpha-beta T cell activation (GO:0035710)3.14343242
114regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.14008945
115leukocyte degranulation (GO:0043299)3.13462369
116regulation of interleukin-10 production (GO:0032653)3.12926183
117positive regulation of leukocyte mediated immunity (GO:0002705)3.12533810
118positive T cell selection (GO:0043368)3.11417379
119negative regulation of defense response to virus (GO:0050687)3.11121915
120somatic diversification of immunoglobulins (GO:0016445)3.10940801
121regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.10936842
122T cell lineage commitment (GO:0002360)3.10641038
123positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.09818203
124positive regulation of interleukin-10 production (GO:0032733)3.06950832
125positive regulation of T-helper 1 type immune response (GO:0002827)3.06860638
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.06061481
127lymph node development (GO:0048535)3.05152455
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.03278745
129positive regulation of T cell proliferation (GO:0042102)3.00604176
130lung lobe morphogenesis (GO:0060463)3.00226963
131regulation of inflammatory response to antigenic stimulus (GO:0002861)2.99881889
132regulation of lymphocyte mediated immunity (GO:0002706)2.97184014
133positive regulation of keratinocyte differentiation (GO:0045618)2.96975729
134negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96769357
135somatic recombination of immunoglobulin gene segments (GO:0016447)2.96094626
136regulation of isotype switching to IgG isotypes (GO:0048302)2.94394257
137CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.94109496
138T cell homeostasis (GO:0043029)2.91795419
139regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91289790
140negative regulation of meiosis (GO:0045835)2.91218065
141negative regulation of interleukin-10 production (GO:0032693)2.89806750
142modulation by virus of host process (GO:0019054)2.89201502
143regulation of T cell mediated immunity (GO:0002709)2.89050551
144regulation of timing of cell differentiation (GO:0048505)2.88231322
145trophoblast giant cell differentiation (GO:0060707)2.87332842
146negative regulation of T cell apoptotic process (GO:0070233)2.87073565
147T cell differentiation involved in immune response (GO:0002292)2.86788955
148alpha-beta T cell differentiation involved in immune response (GO:0002293)2.86788955
149alpha-beta T cell activation involved in immune response (GO:0002287)2.86788955
150dendritic cell differentiation (GO:0097028)2.86541402
151regulation of cell killing (GO:0031341)2.85905194
152cellular response to interferon-alpha (GO:0035457)2.85563722
153viral protein processing (GO:0019082)2.84356622
154positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.83774306
155fucose catabolic process (GO:0019317)2.81623022
156L-fucose metabolic process (GO:0042354)2.81623022
157L-fucose catabolic process (GO:0042355)2.81623022
158positive regulation of B cell mediated immunity (GO:0002714)2.79534412
159positive regulation of immunoglobulin mediated immune response (GO:0002891)2.79534412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.49870544
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.45408399
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.00465412
4E2F7_22180533_ChIP-Seq_HELA_Human5.62513089
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.43908039
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01978881
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20080419
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.75346829
9* FLI1_27457419_Chip-Seq_LIVER_Mouse2.71225578
10* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65794102
11GBX2_23144817_ChIP-Seq_PC3_Human2.59816350
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41060948
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.26848032
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.06411928
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97454132
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95575012
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94564315
18* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94088941
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91908961
20RUNX_20019798_ChIP-Seq_JUKART_Human1.89841236
21* NFE2_27457419_Chip-Seq_LIVER_Mouse1.81862540
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73138520
23ZNF274_21170338_ChIP-Seq_K562_Hela1.71696479
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70071953
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68449375
26* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.65005968
27* EZH2_27294783_Chip-Seq_NPCs_Mouse1.64069963
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61957728
29TAF15_26573619_Chip-Seq_HEK293_Human1.61142762
30* NMYC_18555785_Chip-Seq_ESCs_Mouse1.58728108
31* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56322977
32* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50808784
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49521073
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.49272946
35VDR_22108803_ChIP-Seq_LS180_Human1.48842169
36* STAT3_18555785_Chip-Seq_ESCs_Mouse1.48414732
37* E2F1_18555785_Chip-Seq_ESCs_Mouse1.48399295
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47137590
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46409511
40* P300_18555785_Chip-Seq_ESCs_Mouse1.44274200
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.44249372
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42852706
43MYB_26560356_Chip-Seq_TH2_Human1.42424993
44* CMYC_18555785_Chip-Seq_ESCs_Mouse1.41105489
45* P53_22387025_ChIP-Seq_ESCs_Mouse1.40129828
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39706111
47LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37322738
48* ZFX_18555785_Chip-Seq_ESCs_Mouse1.36306372
49* OCT4_18555785_Chip-Seq_ESCs_Mouse1.33944493
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32640809
51* SOX2_18555785_Chip-Seq_ESCs_Mouse1.32548360
52RNF2_27304074_Chip-Seq_NSC_Mouse1.30672629
53* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29873385
54* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29812208
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.29312593
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29214758
57IRF1_19129219_ChIP-ChIP_H3396_Human1.28518334
58* KLF4_18555785_Chip-Seq_ESCs_Mouse1.28213693
59MYB_26560356_Chip-Seq_TH1_Human1.27833173
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27398550
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27339235
62* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25508951
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.24841168
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24590758
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22783113
66EGR1_19032775_ChIP-ChIP_M12_Human1.22156563
67* PU1_27457419_Chip-Seq_LIVER_Mouse1.21665390
68* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21148756
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17933307
70* CTCF_18555785_Chip-Seq_ESCs_Mouse1.17590336
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15102489
72* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13941332
73* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12530430
74* CRX_20693478_ChIP-Seq_RETINA_Mouse1.11988724
75EWS_26573619_Chip-Seq_HEK293_Human1.09759300
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.09510505
77IGF1R_20145208_ChIP-Seq_DFB_Human1.08410428
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07246257
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06918535
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06913342
81AR_21572438_ChIP-Seq_LNCaP_Human1.06419299
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06032348
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05422469
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05046849
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04471396
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.01952876
87VDR_23849224_ChIP-Seq_CD4+_Human1.01256949
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00413907
89* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99867162
90* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97840798
91FOXP3_21729870_ChIP-Seq_TREG_Human0.97061171
92P300_19829295_ChIP-Seq_ESCs_Human0.96664160
93* GATA3_27048872_Chip-Seq_THYMUS_Human0.96399812
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95171682
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95171682
96ER_23166858_ChIP-Seq_MCF-7_Human0.94074501
97MYC_18940864_ChIP-ChIP_HL60_Human0.93974168
98GATA3_26560356_Chip-Seq_TH2_Human0.93813464
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.93518124
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.93474033
101FUS_26573619_Chip-Seq_HEK293_Human0.92801478
102KDM2B_26808549_Chip-Seq_REH_Human0.92769115
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.89479284
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88852694
105TCF4_23295773_ChIP-Seq_U87_Human0.88602140
106ETS1_20019798_ChIP-Seq_JURKAT_Human0.87873429
107IRF8_21731497_ChIP-ChIP_J774_Mouse0.87288452
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86970628
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86305838
110STAT3_23295773_ChIP-Seq_U87_Human0.85621820
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85373063
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85172537
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82597292
114* SMAD4_21799915_ChIP-Seq_A2780_Human0.81149843
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77823585
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.77722590
117ELK1_19687146_ChIP-ChIP_HELA_Human0.77158521
118MAF_26560356_Chip-Seq_TH2_Human0.76760919
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75316234
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74133067
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73282693
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.72796148
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72555413
124TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71700931
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.71323019
126MAF_26560356_Chip-Seq_TH1_Human0.71101536
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69443172
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68643448
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68434280
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.67354244
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.67214700
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.66344990
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65021051
134STAT1_20625510_ChIP-Seq_HELA_Human0.63494992
135FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.62688729
136KDM5A_27292631_Chip-Seq_BREAST_Human0.61920268
137CEBPB_22108803_ChIP-Seq_LS180_Human0.60848972
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.60072940
139NANOG_19829295_ChIP-Seq_ESCs_Human0.59926173
140SOX2_19829295_ChIP-Seq_ESCs_Human0.59926173
141CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.59638831
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.58865932
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.58650110
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.58650110
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.57993921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001849_ear_inflammation7.01598241
2MP0003763_abnormal_thymus_physiology3.54094027
3MP0003436_decreased_susceptibility_to3.31541654
4MP0003866_abnormal_defecation3.20879967
5* MP0001790_abnormal_immune_system3.01726575
6* MP0005387_immune_system_phenotype3.01726575
7MP0004381_abnormal_hair_follicle3.01389797
8MP0005671_abnormal_response_to2.71290139
9MP0002396_abnormal_hematopoietic_system2.69478851
10MP0009785_altered_susceptibility_to2.63815942
11MP0000372_irregular_coat_pigmentation2.60238120
12MP0000685_abnormal_immune_system2.53886432
13MP0006292_abnormal_olfactory_placode2.34264486
14MP0005083_abnormal_biliary_tract2.31768495
15MP0002148_abnormal_hypersensitivity_rea2.30980012
16* MP0001800_abnormal_humoral_immune2.21679039
17MP0003787_abnormal_imprinting2.19931635
18* MP0005000_abnormal_immune_tolerance2.18086730
19MP0002405_respiratory_system_inflammati2.17325441
20MP0005451_abnormal_body_composition2.15997158
21MP0008057_abnormal_DNA_replication2.12321601
22* MP0010155_abnormal_intestine_physiology2.04125943
23MP0000566_synostosis2.01491686
24MP0009384_cardiac_valve_regurgitation1.99576139
25MP0002277_abnormal_respiratory_mucosa1.97310691
26MP0008875_abnormal_xenobiotic_pharmacok1.96204566
27* MP0002933_joint_inflammation1.95088707
28* MP0002723_abnormal_immune_serum1.93931133
29MP0009333_abnormal_splenocyte_physiolog1.93570872
30MP0000015_abnormal_ear_pigmentation1.90369792
31MP0003136_yellow_coat_color1.89029973
32MP0001243_abnormal_dermal_layer1.81624402
33* MP0002452_abnormal_antigen_presenting1.75784096
34MP0000703_abnormal_thymus_morphology1.71970127
35* MP0002420_abnormal_adaptive_immunity1.71088506
36MP0001663_abnormal_digestive_system1.70173389
37MP0004742_abnormal_vestibular_system1.67300198
38* MP0001819_abnormal_immune_cell1.64602501
39MP0005409_darkened_coat_color1.62954184
40MP0002876_abnormal_thyroid_physiology1.61691342
41MP0002398_abnormal_bone_marrow1.59311242
42MP0001188_hyperpigmentation1.58337496
43* MP0005025_abnormal_response_to1.57327591
44MP0005171_absent_coat_pigmentation1.54593510
45MP0001835_abnormal_antigen_presentation1.54112542
46MP0003300_gastrointestinal_ulcer1.49389778
47MP0002102_abnormal_ear_morphology1.44504741
48MP0000716_abnormal_immune_system1.44154308
49MP0000689_abnormal_spleen_morphology1.43709763
50MP0008877_abnormal_DNA_methylation1.42289192
51MP0002722_abnormal_immune_system1.38194544
52MP0010094_abnormal_chromosome_stability1.38098476
53MP0005310_abnormal_salivary_gland1.33117031
54MP0008058_abnormal_DNA_repair1.32924235
55MP0002419_abnormal_innate_immunity1.32698011
56MP0003111_abnormal_nucleus_morphology1.31929654
57MP0000490_abnormal_crypts_of1.29527394
58MP0003724_increased_susceptibility_to1.28751267
59MP0005381_digestive/alimentary_phenotyp1.27830719
60MP0008873_increased_physiological_sensi1.25939003
61MP0002638_abnormal_pupillary_reflex1.23468218
62MP0009764_decreased_sensitivity_to1.20608116
63MP0005645_abnormal_hypothalamus_physiol1.20597002
64MP0002132_abnormal_respiratory_system1.20450313
65MP0008469_abnormal_protein_level1.17373266
66MP0002009_preneoplasia1.14667761
67MP0005499_abnormal_olfactory_system1.14362232
68MP0005394_taste/olfaction_phenotype1.14362232
69MP0005174_abnormal_tail_pigmentation1.13817298
70MP0001529_abnormal_vocalization1.12180189
71MP0005319_abnormal_enzyme/_coenzyme1.11488645
72MP0001881_abnormal_mammary_gland1.10999355
73MP0001727_abnormal_embryo_implantation1.09582342
74MP0002429_abnormal_blood_cell1.08373637
75MP0004782_abnormal_surfactant_physiolog1.07661825
76MP0008569_lethality_at_weaning1.07466937
77MP0005360_urolithiasis1.04899027
78MP0002138_abnormal_hepatobiliary_system1.04480058
79MP0002254_reproductive_system_inflammat1.01445279
80MP0002006_tumorigenesis1.01043313
81MP0000465_gastrointestinal_hemorrhage0.99906485
82MP0001853_heart_inflammation0.99616410
83* MP0001845_abnormal_inflammatory_respons0.99245056
84MP0003186_abnormal_redox_activity0.99206329
85MP0003878_abnormal_ear_physiology0.98412854
86MP0005377_hearing/vestibular/ear_phenot0.98412854
87MP0005084_abnormal_gallbladder_morpholo0.98103981
88MP0008789_abnormal_olfactory_epithelium0.98064657
89MP0005623_abnormal_meninges_morphology0.97589728
90MP0005075_abnormal_melanosome_morpholog0.97332201
91MP0005187_abnormal_penis_morphology0.95163115
92MP0000627_abnormal_mammary_gland0.93302781
93MP0005379_endocrine/exocrine_gland_phen0.93297796
94MP0001216_abnormal_epidermal_layer0.92487507
95MP0001501_abnormal_sleep_pattern0.91325257
96MP0002163_abnormal_gland_morphology0.89580424
97MP0008007_abnormal_cellular_replicative0.88452669
98MP0002693_abnormal_pancreas_physiology0.87204782
99MP0001502_abnormal_circadian_rhythm0.86396026
100MP0003718_maternal_effect0.85955963
101MP0001533_abnormal_skeleton_physiology0.85446871
102MP0006082_CNS_inflammation0.84695255
103MP0003252_abnormal_bile_duct0.84129054
104MP0005646_abnormal_pituitary_gland0.83807631
105MP0001873_stomach_inflammation0.83805466
106MP0008932_abnormal_embryonic_tissue0.83012410
107MP0001986_abnormal_taste_sensitivity0.81314089
108MP0002095_abnormal_skin_pigmentation0.80965605
109MP0001984_abnormal_olfaction0.79850822
110MP0003121_genomic_imprinting0.77998305
111MP0000604_amyloidosis0.77448402
112MP0003329_amyloid_beta_deposits0.75033189
113MP0000026_abnormal_inner_ear0.74759445
114MP0005365_abnormal_bile_salt0.74613025
115MP0004142_abnormal_muscle_tone0.72231847
116MP0001119_abnormal_female_reproductive0.70781882
117MP0001666_abnormal_nutrient_absorption0.69316810
118MP0006072_abnormal_retinal_apoptosis0.69133642
119MP0004808_abnormal_hematopoietic_stem0.67418710
120MP0000383_abnormal_hair_follicle0.67269746
121MP0003786_premature_aging0.67166108
122MP0005647_abnormal_sex_gland0.66536974
123MP0001348_abnormal_lacrimal_gland0.66058286
124MP0003943_abnormal_hepatobiliary_system0.65237104
125MP0003936_abnormal_reproductive_system0.64746736
126MP0002166_altered_tumor_susceptibility0.63707788
127MP0008260_abnormal_autophagy0.63152116
128MP0001963_abnormal_hearing_physiology0.62621711
129MP0003938_abnormal_ear_development0.62434681
130MP0002998_abnormal_bone_remodeling0.62317482
131MP0001764_abnormal_homeostasis0.58542155
132MP0000609_abnormal_liver_physiology0.58022528
133MP0008872_abnormal_physiological_respon0.57799495
134MP0004215_abnormal_myocardial_fiber0.56238010
135MP0003195_calcinosis0.54911077
136MP0005253_abnormal_eye_physiology0.53006783
137MP0005584_abnormal_enzyme/coenzyme_acti0.52569592
138MP0005670_abnormal_white_adipose0.49539182
139MP0001191_abnormal_skin_condition0.48688465
140MP0005390_skeleton_phenotype0.48639820
141MP0009765_abnormal_xenobiotic_induced0.48558916
142MP0005595_abnormal_vascular_smooth0.47186646
143MP0005636_abnormal_mineral_homeostasis0.46930463

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)5.97303016
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.24735964
3Chromsome breakage (HP:0040012)4.79838795
4Dyschromatopsia (HP:0007641)4.35237730
5Retrobulbar optic neuritis (HP:0100654)4.21436684
6Optic neuritis (HP:0100653)4.21436684
7Panhypogammaglobulinemia (HP:0003139)4.20956742
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.18489680
9Duplicated collecting system (HP:0000081)3.91993989
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.78839085
11Abnormality of placental membranes (HP:0011409)3.69655510
12Amniotic constriction ring (HP:0009775)3.69655510
13Abnormality of the renal collecting system (HP:0004742)3.69462157
14IgA deficiency (HP:0002720)3.63633904
15Vitreoretinal degeneration (HP:0000655)3.62055849
16T lymphocytopenia (HP:0005403)3.59035065
17Increased hepatocellular lipid droplets (HP:0006565)3.44341636
18Abnormality of T cell number (HP:0011839)3.44144301
19Pulmonary infiltrates (HP:0002113)3.42705892
20Ectopic kidney (HP:0000086)3.38332818
21Lipid accumulation in hepatocytes (HP:0006561)3.25241201
22Abolished electroretinogram (ERG) (HP:0000550)3.24930042
23Aplasia cutis congenita (HP:0001057)3.21441052
24Abnormal rod and cone electroretinograms (HP:0008323)3.15900909
25Autoimmune hemolytic anemia (HP:0001890)3.11071815
26IgM deficiency (HP:0002850)3.08672644
27Orchitis (HP:0100796)3.01065789
28Myositis (HP:0100614)2.99882401
29Abnormality of T cells (HP:0002843)2.96360979
30Aplasia of the musculature (HP:0100854)2.94746582
31Aplasia/Hypoplasia involving the musculature (HP:0001460)2.92376295
32Bile duct proliferation (HP:0001408)2.92264481
33Abnormal biliary tract physiology (HP:0012439)2.92264481
34Periodontitis (HP:0000704)2.89027716
35Severe combined immunodeficiency (HP:0004430)2.79794970
36Eczematoid dermatitis (HP:0000976)2.79393087
37Recurrent viral infections (HP:0004429)2.77068111
38* Hemoptysis (HP:0002105)2.73448089
39Hypoproteinemia (HP:0003075)2.68455302
40* Recurrent fungal infections (HP:0002841)2.68377900
41Lymphopenia (HP:0001888)2.64225681
42Cellular immunodeficiency (HP:0005374)2.62246531
43Premature loss of primary teeth (HP:0006323)2.62097871
44Abnormality of the preputium (HP:0100587)2.60918165
45Xerostomia (HP:0000217)2.60729331
46Tubular atrophy (HP:0000092)2.54757417
47Mesangial abnormality (HP:0001966)2.54031944
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.53292347
49Stomatitis (HP:0010280)2.51231673
50Abnormality of T cell physiology (HP:0011840)2.49526432
51Inflammation of the large intestine (HP:0002037)2.47642983
52Autoimmune thrombocytopenia (HP:0001973)2.46766422
53Abnormality of DNA repair (HP:0003254)2.43095942
54Abnormality of the renal cortex (HP:0011035)2.41269518
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.40234674
56Absent hand (HP:0004050)2.40109669
57Abnormal hair whorl (HP:0010721)2.39545365
58Clubbing of toes (HP:0100760)2.39184975
59Hypergammaglobulinemia (HP:0010702)2.38948708
60Hypothermia (HP:0002045)2.37599649
61Homocystinuria (HP:0002156)2.36184986
62Abnormality of homocysteine metabolism (HP:0010919)2.36184986
63Keratoconjunctivitis sicca (HP:0001097)2.35337214
64Abnormality of chromosome stability (HP:0003220)2.33051320
65Persistence of primary teeth (HP:0006335)2.30725047
66Congenital ichthyosiform erythroderma (HP:0007431)2.29187454
67Parakeratosis (HP:0001036)2.26662359
68Meningitis (HP:0001287)2.26570314
69Renal Fanconi syndrome (HP:0001994)2.24645220
70Neonatal hypoglycemia (HP:0001998)2.24535812
71Pigmentary retinal degeneration (HP:0001146)2.22229254
72Meckel diverticulum (HP:0002245)2.21780188
73Cutaneous melanoma (HP:0012056)2.21644897
74Gastrointestinal inflammation (HP:0004386)2.21089869
75Prostate neoplasm (HP:0100787)2.20856538
76Adactyly (HP:0009776)2.20698153
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20422065
78Vasculitis (HP:0002633)2.18603170
79Keratoconjunctivitis (HP:0001096)2.14502979
80Squamous cell carcinoma (HP:0002860)2.12901132
81IgG deficiency (HP:0004315)2.12780406
82Mediastinal lymphadenopathy (HP:0100721)2.12168908
83Abnormality of the ileum (HP:0001549)2.11737042
84Abnormality of the prostate (HP:0008775)2.08714850
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08405240
86Slender build (HP:0001533)2.07991859
87Stomach cancer (HP:0012126)2.07097474
88Recurrent sinusitis (HP:0011108)2.05877976
89Metaphyseal cupping (HP:0003021)2.04557683
90Combined immunodeficiency (HP:0005387)2.03979026
91Septo-optic dysplasia (HP:0100842)2.03587285
92Skull defect (HP:0001362)2.03472785
93Increased intramyocellular lipid droplets (HP:0012240)2.01321696
94Generalized aminoaciduria (HP:0002909)1.99666109
95Abnormality of the pleura (HP:0002103)1.98664470
96Obstructive lung disease (HP:0006536)1.98187117
97Chronic obstructive pulmonary disease (HP:0006510)1.98187117
98Increased IgM level (HP:0003496)1.97743365
99Leukopenia (HP:0001882)1.97650366
100Pulmonary fibrosis (HP:0002206)1.97065755
101Joint swelling (HP:0001386)1.96103574
102Hepatosplenomegaly (HP:0001433)1.95080549
103Postaxial foot polydactyly (HP:0001830)1.93753841
104Lower limb hyperreflexia (HP:0002395)1.92667804
105Hypoalbuminemia (HP:0003073)1.92469090
106Abnormal albumin level (HP:0012116)1.92469090
107Congenital stationary night blindness (HP:0007642)1.91526891
108Lymphoma (HP:0002665)1.90447895
109Abnormality of the fingertips (HP:0001211)1.89277075
110Exertional dyspnea (HP:0002875)1.88948742
111Duplication of thumb phalanx (HP:0009942)1.88815040
112Submucous cleft hard palate (HP:0000176)1.88563818
113Polyneuropathy (HP:0001271)1.88367965
114Bundle branch block (HP:0011710)1.88185517
115Arterial thrombosis (HP:0004420)1.85274285
116Basal cell carcinoma (HP:0002671)1.84559788
117Abnormality of eosinophils (HP:0001879)1.84014519
118Respiratory difficulties (HP:0002880)1.83357199
119Malignant hyperthermia (HP:0002047)1.83014458
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82944027
121Colon cancer (HP:0003003)1.82481381
122White forelock (HP:0002211)1.82085093
123Gangrene (HP:0100758)1.81307146
124Clumsiness (HP:0002312)1.81166522
125Pendular nystagmus (HP:0012043)1.79487448
126Absent septum pellucidum (HP:0001331)1.78720664
127Upper limb muscle weakness (HP:0003484)1.78406966
128Nephronophthisis (HP:0000090)1.78107145
129Hypoplastic pelvis (HP:0008839)1.76055007
130Birth length less than 3rd percentile (HP:0003561)1.75152795
131Increased muscle lipid content (HP:0009058)1.74932746
132Leukocytosis (HP:0001974)1.74245573
133Myelodysplasia (HP:0002863)1.74198632
134B lymphocytopenia (HP:0010976)1.74169260
135Abnormality of B cell number (HP:0010975)1.74169260
136Dynein arm defect of respiratory motile cilia (HP:0012255)1.73378881
137Absent/shortened dynein arms (HP:0200106)1.73378881
138Preaxial hand polydactyly (HP:0001177)1.73376067
139Abnormality of the septum pellucidum (HP:0007375)1.73046506
140Encephalitis (HP:0002383)1.72822156
141Horseshoe kidney (HP:0000085)1.72653371
142Palpitations (HP:0001962)1.72309924
143Enlarged epiphyses (HP:0010580)1.72212273
144Glomerulopathy (HP:0100820)1.71845013
145Small intestinal stenosis (HP:0012848)1.71591746
146Duodenal stenosis (HP:0100867)1.71591746
147Eosinophilia (HP:0001880)1.70135945
148Pulmonary embolism (HP:0002204)1.69953617
149Patchy hypopigmentation of hair (HP:0011365)1.69939777
150Bone marrow hypocellularity (HP:0005528)1.67534375
151Atelectasis (HP:0100750)1.67144548
152Increased CSF lactate (HP:0002490)1.66846212
153Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.66780803
154Vertebral hypoplasia (HP:0008417)1.66780803
155Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65995757
156Pancreatic islet-cell hyperplasia (HP:0004510)1.65900521
157Abnormality of the anterior horn cell (HP:0006802)1.65491312
158Abnormality of the nasal septum (HP:0000419)1.64583330
159Abnormality of the hepatic vasculature (HP:0006707)1.63265034
160Anomalous pulmonary venous return (HP:0010772)1.62182993
161Abnormality of the carotid arteries (HP:0005344)1.61998330
162Lip pit (HP:0100267)1.61885435
163Renal cortical cysts (HP:0000803)1.61755021
164Keratitis (HP:0000491)1.61072372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.21963572
2NEK14.97909757
3JAK34.09475919
4MAP2K63.65927056
5MAP3K123.08827306
6MAP4K13.04678560
7MAP3K142.88895323
8EPHA32.80067306
9NLK2.26842735
10IRAK32.21671553
11ACVR1B2.16099475
12EPHB12.07201622
13CLK12.01751307
14CASK2.01554057
15ZAK2.01110001
16BCR1.87498301
17TEC1.86595514
18IRAK11.83178509
19BRD41.81291873
20STK241.80305040
21CDK121.70481509
22IRAK41.69284684
23TNK21.62282386
24ITK1.62195317
25TNIK1.61440827
26MAPKAPK31.54850180
27NEK61.52156414
28EEF2K1.52132518
29MKNK21.44592159
30MYLK1.39891622
31PRPF4B1.37486984
32PHKG11.37193508
33PHKG21.37193508
34BMPR21.36901804
35NUAK11.35720442
36CSF1R1.33969275
37TRIM281.33713721
38WNK41.33482840
39FES1.31344226
40LCK1.25658714
41MAP3K71.21717485
42ZAP701.20021897
43SRPK11.17232946
44BLK1.15099072
45PKN11.14458037
46STK31.12467141
47FGFR41.12242645
48ILK1.09945589
49DAPK11.05301305
50SIK31.04234354
51HCK1.03770638
52TIE11.03383719
53STK391.01793554
54MKNK11.01451250
55BMPR1B1.01408495
56CDC71.01014387
57STK161.00337143
58YES10.99813000
59PLK40.98589748
60BTK0.97188896
61IKBKB0.97072718
62IKBKE0.95069934
63CHUK0.93819226
64EIF2AK20.93104826
65PRKCQ0.88769636
66TYK20.85643246
67TAF10.83941129
68PLK30.82928942
69VRK20.82777894
70JAK10.82555461
71TRPM70.80320013
72PRKCH0.79376594
73RIPK40.77554881
74INSRR0.76352004
75SIK20.75539411
76TTK0.73493788
77MST40.73058386
78PIM20.71283860
79SGK20.71143594
80PASK0.70627286
81TYRO30.69371641
82SYK0.68941983
83NME20.68787776
84RPS6KA50.68485123
85ADRBK20.67682665
86FGFR30.65950020
87WNK10.65798174
88DMPK0.65234874
89CDK30.64420393
90CSNK1A1L0.64156006
91KIT0.63575656
92MARK20.63296758
93TAOK30.62924819
94NME10.62763609
95ALK0.62628224
96CDK90.62489337
97LYN0.61499737
98IRAK20.61299200
99DYRK20.60927656
100NTRK20.60535764
101PAK60.60266031
102RPS6KB10.60090397
103ATR0.57769537
104PNCK0.57373470
105VRK10.56901499
106CHEK10.54458496
107HIPK20.53376572
108OXSR10.52121373
109MAP3K30.52078409
110ATM0.51583994
111SGK2230.51262539
112SGK4940.51262539
113STK38L0.51119989
114TLK10.50523161
115JAK20.49588474
116GRK70.48905981
117STK100.48192513
118TSSK60.47261555
119PBK0.46817267
120PIM10.45962948
121MAPKAPK20.45845340
122CHEK20.45642558
123GRK10.45184479
124CDK40.45015970
125CSNK1D0.43387522
126IGF1R0.43306589
127ROCK20.42870112
128PDK10.42638375
129CDK80.41930512
130SGK30.41615095
131PRKG10.41348739
132PAK40.40674328
133MAP3K130.39605229
134SGK10.38461981
135PRKDC0.36610041
136CSK0.35365922
137BCKDK0.35208706
138CAMK2A0.33616725
139PRKCA0.30304631
140KSR10.30294116
141PRKCB0.30103271
142CSNK2A10.29486203
143PTK2B0.28347787
144EGFR0.27715831
145CAMK2D0.27123679
146GSK3A0.26757947
147PINK10.26598401
148PRKACA0.25810668
149PRKACG0.21902060
150CSNK1A10.21529132
151MAPK30.20396028
152INSR0.20366699

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.82555267
2* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.59396568
3Proteasome_Homo sapiens_hsa030503.66116212
4Primary immunodeficiency_Homo sapiens_hsa053402.96984998
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.71959410
6Autoimmune thyroid disease_Homo sapiens_hsa053202.65134917
7Allograft rejection_Homo sapiens_hsa053302.44127873
8Jak-STAT signaling pathway_Homo sapiens_hsa046302.43777663
9Type I diabetes mellitus_Homo sapiens_hsa049402.40219539
10Measles_Homo sapiens_hsa051622.37286331
11Graft-versus-host disease_Homo sapiens_hsa053322.36317262
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.31743362
13Fanconi anemia pathway_Homo sapiens_hsa034602.22719056
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.21538231
15T cell receptor signaling pathway_Homo sapiens_hsa046602.19798675
16Homologous recombination_Homo sapiens_hsa034401.98898707
17Asthma_Homo sapiens_hsa053101.92524319
18Hematopoietic cell lineage_Homo sapiens_hsa046401.83449522
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77104875
20Rheumatoid arthritis_Homo sapiens_hsa053231.67496633
21DNA replication_Homo sapiens_hsa030301.60580032
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41966180
23Non-homologous end-joining_Homo sapiens_hsa034501.40317009
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35103932
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31265352
26One carbon pool by folate_Homo sapiens_hsa006701.30755927
27Mismatch repair_Homo sapiens_hsa034301.28299976
28RNA degradation_Homo sapiens_hsa030181.25608897
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23727211
30Base excision repair_Homo sapiens_hsa034101.23093656
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21464913
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20267188
33Basal transcription factors_Homo sapiens_hsa030221.19988104
34Viral myocarditis_Homo sapiens_hsa054161.19966215
35RNA polymerase_Homo sapiens_hsa030201.17367568
36Regulation of autophagy_Homo sapiens_hsa041401.17249796
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16935237
38Herpes simplex infection_Homo sapiens_hsa051681.12108921
39Leishmaniasis_Homo sapiens_hsa051401.05463877
40Nucleotide excision repair_Homo sapiens_hsa034201.03324982
41HTLV-I infection_Homo sapiens_hsa051661.03027395
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01919399
43Steroid biosynthesis_Homo sapiens_hsa001001.01400410
44Chemokine signaling pathway_Homo sapiens_hsa040621.00405263
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.00044057
46TNF signaling pathway_Homo sapiens_hsa046680.98687790
47Acute myeloid leukemia_Homo sapiens_hsa052210.97203630
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92710681
49Prolactin signaling pathway_Homo sapiens_hsa049170.89304888
50Ether lipid metabolism_Homo sapiens_hsa005650.88869569
51Cell cycle_Homo sapiens_hsa041100.87165432
52Osteoclast differentiation_Homo sapiens_hsa043800.86975913
53Pyrimidine metabolism_Homo sapiens_hsa002400.86187161
54Epstein-Barr virus infection_Homo sapiens_hsa051690.86023974
55Sphingolipid metabolism_Homo sapiens_hsa006000.86001940
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85725222
57Nitrogen metabolism_Homo sapiens_hsa009100.82656186
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82612861
59Viral carcinogenesis_Homo sapiens_hsa052030.81002737
60RNA transport_Homo sapiens_hsa030130.77888936
61Antigen processing and presentation_Homo sapiens_hsa046120.76850785
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75731564
63Spliceosome_Homo sapiens_hsa030400.73877443
64B cell receptor signaling pathway_Homo sapiens_hsa046620.73652100
65African trypanosomiasis_Homo sapiens_hsa051430.72278998
66Circadian rhythm_Homo sapiens_hsa047100.71616661
67Hepatitis B_Homo sapiens_hsa051610.70704826
68Oxidative phosphorylation_Homo sapiens_hsa001900.70557231
69Influenza A_Homo sapiens_hsa051640.70420029
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68683164
71Protein export_Homo sapiens_hsa030600.68417246
72mRNA surveillance pathway_Homo sapiens_hsa030150.67688586
73Malaria_Homo sapiens_hsa051440.65656048
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64080793
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63022515
76Purine metabolism_Homo sapiens_hsa002300.61452383
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61260073
78Renal cell carcinoma_Homo sapiens_hsa052110.59608382
79Phototransduction_Homo sapiens_hsa047440.59147746
80Nicotine addiction_Homo sapiens_hsa050330.58155205
81Arachidonic acid metabolism_Homo sapiens_hsa005900.57222396
82Propanoate metabolism_Homo sapiens_hsa006400.57104683
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57000909
84Toxoplasmosis_Homo sapiens_hsa051450.56246936
85Notch signaling pathway_Homo sapiens_hsa043300.55782126
86p53 signaling pathway_Homo sapiens_hsa041150.53388522
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52647499
88Prostate cancer_Homo sapiens_hsa052150.52287484
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.51739483
90MAPK signaling pathway_Homo sapiens_hsa040100.51181690
91Parkinsons disease_Homo sapiens_hsa050120.45318835
92Linoleic acid metabolism_Homo sapiens_hsa005910.42691823
93Vitamin B6 metabolism_Homo sapiens_hsa007500.42098981
94Hepatitis C_Homo sapiens_hsa051600.40986923
95Chronic myeloid leukemia_Homo sapiens_hsa052200.40249421
96MicroRNAs in cancer_Homo sapiens_hsa052060.38521509
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38083948
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37988617
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37944999
100Peroxisome_Homo sapiens_hsa041460.37819877
101Choline metabolism in cancer_Homo sapiens_hsa052310.35985886
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35529004
103Tuberculosis_Homo sapiens_hsa051520.34441342
104Vitamin digestion and absorption_Homo sapiens_hsa049770.33696557
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33576775
106Serotonergic synapse_Homo sapiens_hsa047260.33444593
107HIF-1 signaling pathway_Homo sapiens_hsa040660.32647113
108Morphine addiction_Homo sapiens_hsa050320.32583053
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32537158
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30811994
111Pancreatic cancer_Homo sapiens_hsa052120.30483257
112Fatty acid biosynthesis_Homo sapiens_hsa000610.29900857
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29265758
114Staphylococcus aureus infection_Homo sapiens_hsa051500.27896409
115Pathways in cancer_Homo sapiens_hsa052000.27867250
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27702976
117Tryptophan metabolism_Homo sapiens_hsa003800.27699141
118Fatty acid elongation_Homo sapiens_hsa000620.27354056
119Apoptosis_Homo sapiens_hsa042100.27217111
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26197386
121Axon guidance_Homo sapiens_hsa043600.24901310
122Taste transduction_Homo sapiens_hsa047420.24659876
123mTOR signaling pathway_Homo sapiens_hsa041500.24133788
124Sulfur relay system_Homo sapiens_hsa041220.21586440
125Collecting duct acid secretion_Homo sapiens_hsa049660.21171307
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16188820
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15988982
128Huntingtons disease_Homo sapiens_hsa050160.15773146
129Platelet activation_Homo sapiens_hsa046110.13947023
130Systemic lupus erythematosus_Homo sapiens_hsa053220.10390660
131Chemical carcinogenesis_Homo sapiens_hsa052040.10311472
132Endocytosis_Homo sapiens_hsa041440.06693795
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.03778243
134Alzheimers disease_Homo sapiens_hsa050100.01989193
135Metabolic pathways_Homo sapiens_hsa011000.01538873
136Vibrio cholerae infection_Homo sapiens_hsa051100.00599834

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