IL17RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.20950027
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.25126007
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25126007
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01999136
5detection of other organism (GO:0098543)4.95708067
6antigen processing and presentation of endogenous antigen (GO:0019883)4.83880633
7regulation of gamma-delta T cell differentiation (GO:0045586)4.82045892
8regulation of B cell receptor signaling pathway (GO:0050855)4.69405235
9leukocyte aggregation (GO:0070486)4.64938156
10detection of molecule of bacterial origin (GO:0032490)4.63839874
11detection of bacterium (GO:0016045)4.63124070
12regulation of gamma-delta T cell activation (GO:0046643)4.59740178
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56596639
14positive regulation of B cell differentiation (GO:0045579)4.48500778
15detection of external biotic stimulus (GO:0098581)4.43939578
16negative regulation of cell killing (GO:0031342)4.41051894
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41051894
18microglial cell activation (GO:0001774)4.23886920
19B cell receptor signaling pathway (GO:0050853)4.23523843
20regulation of B cell differentiation (GO:0045577)4.22611940
21positive thymic T cell selection (GO:0045059)4.10033644
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.02725742
23negative regulation of lymphocyte mediated immunity (GO:0002707)4.00881842
24positive regulation by symbiont of host defense response (GO:0052509)3.93358881
25modulation by symbiont of host defense response (GO:0052031)3.93358881
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93358881
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93358881
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.93358881
29modulation by symbiont of host immune response (GO:0052553)3.93358881
30detection of biotic stimulus (GO:0009595)3.92944389
31macrophage activation (GO:0042116)3.87705414
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.79833853
33regulation of mast cell degranulation (GO:0043304)3.74749538
34negative regulation of T cell mediated immunity (GO:0002710)3.74383799
35interferon-gamma production (GO:0032609)3.73146023
36neutrophil mediated immunity (GO:0002446)3.72799936
37leukocyte migration involved in inflammatory response (GO:0002523)3.72457504
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.63284937
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62036557
40cellular extravasation (GO:0045123)3.61653069
41negative regulation of leukocyte mediated immunity (GO:0002704)3.61371135
42negative regulation of phagocytosis (GO:0050765)3.60988462
43response to interleukin-15 (GO:0070672)3.59536565
44negative T cell selection (GO:0043383)3.58379980
45positive regulation of mast cell activation (GO:0033005)3.55682275
46positive T cell selection (GO:0043368)3.54104074
47regulation of interferon-beta biosynthetic process (GO:0045357)3.50639477
48tolerance induction (GO:0002507)3.49675191
49regulation of mast cell activation involved in immune response (GO:0033006)3.46623769
50regulation of leukocyte degranulation (GO:0043300)3.45506995
51negative thymic T cell selection (GO:0045060)3.44103428
52T cell homeostasis (GO:0043029)3.39361510
53T cell migration (GO:0072678)3.38627108
54regulation of mast cell activation (GO:0033003)3.36284060
55lymphocyte homeostasis (GO:0002260)3.35261397
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.33739217
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.32778679
58B cell homeostasis (GO:0001782)3.31848745
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.30491862
60antigen receptor-mediated signaling pathway (GO:0050851)3.28597331
61production of molecular mediator involved in inflammatory response (GO:0002532)3.26639776
62negative regulation of interleukin-12 production (GO:0032695)3.26143382
63myeloid leukocyte mediated immunity (GO:0002444)3.25719281
64mature B cell differentiation (GO:0002335)3.23384597
65mast cell activation (GO:0045576)3.21509159
66immunoglobulin mediated immune response (GO:0016064)3.20690991
67thymic T cell selection (GO:0045061)3.19656761
68T cell selection (GO:0045058)3.18366315
69germinal center formation (GO:0002467)3.18147898
70neutrophil activation (GO:0042119)3.18102365
71cellular response to interleukin-15 (GO:0071350)3.16109654
72antigen processing and presentation via MHC class Ib (GO:0002475)3.15629966
73macrophage activation involved in immune response (GO:0002281)3.15406844
74leukocyte degranulation (GO:0043299)3.13777726
75positive regulation of mast cell activation involved in immune response (GO:0033008)3.11097761
76positive regulation of mast cell degranulation (GO:0043306)3.11097761
77response to muramyl dipeptide (GO:0032495)3.10726264
78neutrophil activation involved in immune response (GO:0002283)3.10667507
79regulation of tolerance induction (GO:0002643)3.10611272
80leukocyte cell-cell adhesion (GO:0007159)3.10316417
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10225209
82positive regulation of granulocyte differentiation (GO:0030854)3.04335796
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03369768
84negative regulation of interleukin-6 production (GO:0032715)3.03142471
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03140523
86regulation of T cell tolerance induction (GO:0002664)3.01711737
87leukocyte homeostasis (GO:0001776)3.01175980
88negative regulation of granulocyte differentiation (GO:0030853)3.00464456
89T cell receptor signaling pathway (GO:0050852)2.99661151
90regulation of regulated secretory pathway (GO:1903305)2.99525937
91granulocyte activation (GO:0036230)2.94837468
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94595109
93JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.92645082
94interferon-gamma-mediated signaling pathway (GO:0060333)2.92531914
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91769657
96myeloid leukocyte activation (GO:0002274)2.90530601
97B cell mediated immunity (GO:0019724)2.90491887
98respiratory burst (GO:0045730)2.89797527
99positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88682393
100positive regulation of cellular amide metabolic process (GO:0034250)2.88350021
101myeloid dendritic cell activation (GO:0001773)2.87619529
102negative regulation of type 2 immune response (GO:0002829)2.87474825
103regulation of T cell receptor signaling pathway (GO:0050856)2.86778172
104myeloid cell activation involved in immune response (GO:0002275)2.86650951
105positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85943762
106NIK/NF-kappaB signaling (GO:0038061)2.85900117
107neutrophil chemotaxis (GO:0030593)2.85760495
108dendritic cell migration (GO:0036336)2.84921573
109response to protozoan (GO:0001562)2.84446976
110response to peptidoglycan (GO:0032494)2.83767567
111regulation of T-helper 2 cell differentiation (GO:0045628)2.83327669
112negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82963516
113negative regulation of T-helper cell differentiation (GO:0045623)2.82963516
114negative regulation of erythrocyte differentiation (GO:0045647)2.81561175
115definitive hemopoiesis (GO:0060216)2.80980938
116defense response to protozoan (GO:0042832)2.77890517
117positive regulation of interleukin-2 production (GO:0032743)2.77595583
118negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.77581579
119regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76791958
120positive regulation of interferon-alpha production (GO:0032727)2.75069978
121regulation of granulocyte differentiation (GO:0030852)2.74126637
122response to type I interferon (GO:0034340)2.71564570
123B cell proliferation (GO:0042100)2.71173258
124lymph node development (GO:0048535)2.70840532
125natural killer cell differentiation (GO:0001779)2.70614091
126response to host immune response (GO:0052572)2.70135583
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70135583
128activated T cell proliferation (GO:0050798)2.67475963
129positive regulation of histone deacetylation (GO:0031065)2.64227438
130natural killer cell activation (GO:0030101)2.63951751
131regulation of interferon-alpha production (GO:0032647)2.62467520
132type I interferon signaling pathway (GO:0060337)2.62009684
133cellular response to type I interferon (GO:0071357)2.62009684
134regulation of alpha-beta T cell proliferation (GO:0046640)2.60694539
135negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.60502440
136response to host defenses (GO:0052200)2.60363603
137response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60363603
138response to host (GO:0075136)2.60363603
139T cell costimulation (GO:0031295)2.59926932
140myeloid dendritic cell differentiation (GO:0043011)2.59600683
141mature B cell differentiation involved in immune response (GO:0002313)2.59435574
142positive regulation of B cell activation (GO:0050871)2.59236452
143mast cell activation involved in immune response (GO:0002279)2.58525106
144mast cell degranulation (GO:0043303)2.58525106
145negative regulation of B cell proliferation (GO:0030889)2.57389436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.83758934
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.60274959
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51714096
4E2F7_22180533_ChIP-Seq_HELA_Human4.27338705
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.87885052
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69381554
7MYC_22102868_ChIP-Seq_BL_Human3.49086937
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.41330880
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32215576
10SCL_19346495_ChIP-Seq_HPC-7_Human3.22525159
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.16029197
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02870305
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.94601190
14VDR_21846776_ChIP-Seq_THP-1_Human2.91777596
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85135287
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84364356
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84226305
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.79061712
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78741387
20RUNX_20019798_ChIP-Seq_JUKART_Human2.74789568
21* MYB_26560356_Chip-Seq_TH2_Human2.66499866
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57044481
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51273399
24* MAF_26560356_Chip-Seq_TH1_Human2.44893609
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43658862
26* MYB_26560356_Chip-Seq_TH1_Human2.39205222
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37987276
28SPI1_23547873_ChIP-Seq_NB4_Human2.31661304
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30346683
30* UTX_26944678_Chip-Seq_JUKART_Human2.27676331
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.26751890
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24929223
33* VDR_24763502_ChIP-Seq_THP-1_Human2.22900237
34* TCF7_22412390_ChIP-Seq_EML_Mouse2.16433734
35* RUNX1_22412390_ChIP-Seq_EML_Mouse2.12730153
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06605144
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02850535
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.99853807
39SPI1_23127762_ChIP-Seq_K562_Human1.84197484
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74670387
41* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73465676
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67017397
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66061368
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.65697599
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65684616
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65472301
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62997891
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60246015
49PU_27001747_Chip-Seq_BMDM_Mouse1.57196904
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.56978973
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55392799
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54898468
53MAF_26560356_Chip-Seq_TH2_Human1.53142157
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52380485
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51099046
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48267238
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43545441
58KDM2B_26808549_Chip-Seq_DND41_Human1.41725614
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36751055
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36323174
61CIITA_25753668_ChIP-Seq_RAJI_Human1.34479293
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34172891
63GATA1_22025678_ChIP-Seq_K562_Human1.31370625
64* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29995118
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29669522
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29522761
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28411833
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28007655
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27215698
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25570447
71* ELK3_25401928_ChIP-Seq_HUVEC_Human1.23077093
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21807450
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21746725
74* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21270791
75LXR_22292898_ChIP-Seq_THP-1_Human1.20808453
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.16324886
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15098377
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13765435
79GATA3_26560356_Chip-Seq_TH2_Human1.09398931
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08340805
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06960000
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05777809
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03344292
84VDR_24787735_ChIP-Seq_THP-1_Human1.02602489
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01707633
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00345517
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98900202
88NCOR1_26117541_ChIP-Seq_K562_Human0.96414457
89BCL6_27268052_Chip-Seq_Bcells_Human0.95223834
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94682429
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94027581
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90027805
93BCOR_27268052_Chip-Seq_Bcells_Human0.89489661
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87728928
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86395601
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85669332
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84974155
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.84329531
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84052159
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84028811
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.84014664
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.83679100
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.83253967
104GATA2_19941826_ChIP-Seq_K562_Human0.83223460
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82367371
106SPI1_20517297_ChIP-Seq_HL60_Human0.82255068
107GATA1_19941826_ChIP-Seq_K562_Human0.80770846
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79806270
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78990431
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77154425
111FOXP3_21729870_ChIP-Seq_TREG_Human0.75726836
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75708663
113* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74990220
114* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74848129
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71950758
116VDR_23849224_ChIP-Seq_CD4+_Human0.71716864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.59315104
2MP0002396_abnormal_hematopoietic_system3.18757613
3MP0001800_abnormal_humoral_immune3.13771090
4MP0000685_abnormal_immune_system3.06162372
5MP0005671_abnormal_response_to3.02571665
6MP0003436_decreased_susceptibility_to3.00217621
7MP0003303_peritoneal_inflammation2.91969536
8MP0005387_immune_system_phenotype2.91045651
9MP0001790_abnormal_immune_system2.91045651
10MP0003763_abnormal_thymus_physiology2.86063073
11MP0002452_abnormal_antigen_presenting2.75322633
12MP0005000_abnormal_immune_tolerance2.70698406
13* MP0002723_abnormal_immune_serum2.62632593
14* MP0002420_abnormal_adaptive_immunity2.57133208
15* MP0001819_abnormal_immune_cell2.54488736
16MP0009785_altered_susceptibility_to2.51841125
17* MP0002398_abnormal_bone_marrow2.48061473
18* MP0002419_abnormal_innate_immunity2.45549188
19MP0009278_abnormal_bone_marrow2.43712165
20* MP0005025_abnormal_response_to2.39963821
21MP0005464_abnormal_platelet_physiology2.33143011
22MP0004808_abnormal_hematopoietic_stem2.30891158
23MP0003300_gastrointestinal_ulcer2.29207182
24MP0002166_altered_tumor_susceptibility2.24039510
25* MP0000716_abnormal_immune_system2.22207007
26MP0000689_abnormal_spleen_morphology2.10064565
27MP0002148_abnormal_hypersensitivity_rea2.09292676
28MP0005397_hematopoietic_system_phenotyp2.09002720
29MP0001545_abnormal_hematopoietic_system2.09002720
30MP0008260_abnormal_autophagy2.07613475
31MP0002405_respiratory_system_inflammati2.06004863
32MP0003724_increased_susceptibility_to2.05085463
33MP0002722_abnormal_immune_system2.03022174
34MP0001853_heart_inflammation1.99792706
35MP0004947_skin_inflammation1.94095936
36MP0000703_abnormal_thymus_morphology1.91840914
37MP0010155_abnormal_intestine_physiology1.87329088
38* MP0002429_abnormal_blood_cell1.87035669
39MP0009333_abnormal_splenocyte_physiolog1.84895533
40MP0001873_stomach_inflammation1.83334698
41MP0002006_tumorigenesis1.82900602
42MP0005451_abnormal_body_composition1.77807870
43* MP0001845_abnormal_inflammatory_respons1.69514740
44MP0000465_gastrointestinal_hemorrhage1.66211314
45MP0005174_abnormal_tail_pigmentation1.65284633
46MP0006082_CNS_inflammation1.61679017
47MP0004883_abnormal_blood_vessel1.57558352
48MP0002933_joint_inflammation1.56371382
49MP0001533_abnormal_skeleton_physiology1.49803060
50MP0004510_myositis1.49155158
51MP0000569_abnormal_digit_pigmentation1.42487093
52MP0003866_abnormal_defecation1.41492448
53MP0000490_abnormal_crypts_of1.40406223
54MP0003191_abnormal_cellular_cholesterol1.38694273
55* MP0003828_pulmonary_edema1.34706677
56MP0000858_altered_metastatic_potential1.34232250
57MP0003183_abnormal_peptide_metabolism1.29502243
58MP0008469_abnormal_protein_level1.27200340
59MP0003690_abnormal_glial_cell1.23511937
60MP0005164_abnormal_response_to1.20188793
61MP0003448_altered_tumor_morphology1.19624956
62MP0000604_amyloidosis1.18405872
63MP0003172_abnormal_lysosome_physiology1.14699043
64MP0001851_eye_inflammation1.14625265
65MP0005058_abnormal_lysosome_morphology1.13895970
66MP0005310_abnormal_salivary_gland1.12248526
67MP0005075_abnormal_melanosome_morpholog1.09231844
68MP0010352_gastrointestinal_tract_polyps1.07595191
69MP0000015_abnormal_ear_pigmentation1.05727883
70MP0002019_abnormal_tumor_incidence1.02721648
71MP0002998_abnormal_bone_remodeling1.02147543
72MP0009764_decreased_sensitivity_to1.00194451
73MP0005076_abnormal_cell_differentiation1.00164768
74MP0010307_abnormal_tumor_latency0.99574579
75MP0002095_abnormal_skin_pigmentation0.92890566
76MP0008057_abnormal_DNA_replication0.91619435
77MP0002132_abnormal_respiratory_system0.90801969
78MP0009840_abnormal_foam_cell0.90123489
79MP0008004_abnormal_stomach_pH0.87877361
80MP0010094_abnormal_chromosome_stability0.87538109
81MP0005023_abnormal_wound_healing0.83201636
82MP0003566_abnormal_cell_adhesion0.81746452
83MP0000343_altered_response_to0.79845930
84MP0003693_abnormal_embryo_hatching0.79459499
85MP0002928_abnormal_bile_duct0.77789006
86MP0001986_abnormal_taste_sensitivity0.77610983
87MP0004130_abnormal_muscle_cell0.77539021
88MP0003077_abnormal_cell_cycle0.76432073
89MP0003091_abnormal_cell_migration0.75958385
90MP0008961_abnormal_basal_metabolism0.75443231
91MP0008007_abnormal_cellular_replicative0.74650432
92MP0009763_increased_sensitivity_to0.74640732
93MP0002277_abnormal_respiratory_mucosa0.73626050
94MP0005390_skeleton_phenotype0.72464994
95MP0003453_abnormal_keratinocyte_physiol0.70761830
96MP0005166_decreased_susceptibility_to0.70038047
97MP0003795_abnormal_bone_structure0.69862928
98MP0000371_diluted_coat_color0.67266553
99MP0003329_amyloid_beta_deposits0.64919769
100MP0000609_abnormal_liver_physiology0.64291287
101MP0002138_abnormal_hepatobiliary_system0.63153366
102MP0003279_aneurysm0.62340901
103MP0003656_abnormal_erythrocyte_physiolo0.61246117
104MP0000249_abnormal_blood_vessel0.61069685
105MP0001958_emphysema0.60991016
106MP0004381_abnormal_hair_follicle0.60417244
107MP0001663_abnormal_digestive_system0.60233094
108MP0008874_decreased_physiological_sensi0.60082497
109MP0003045_fibrosis0.59746816
110MP0009765_abnormal_xenobiotic_induced0.59312352
111MP0006054_spinal_hemorrhage0.58445277
112MP0003111_abnormal_nucleus_morphology0.58141028
113MP0000313_abnormal_cell_death0.57523714
114MP0002136_abnormal_kidney_physiology0.56899321
115MP0001191_abnormal_skin_condition0.56402191
116MP0003221_abnormal_cardiomyocyte_apopto0.56300619
117MP0003075_altered_response_to0.54761510
118MP0002009_preneoplasia0.52823285
119MP0005319_abnormal_enzyme/_coenzyme0.51686458
120MP0002332_abnormal_exercise_endurance0.51332244

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.84131731
2Eczematoid dermatitis (HP:0000976)4.70793416
3Recurrent viral infections (HP:0004429)4.56450206
4Recurrent bacterial skin infections (HP:0005406)4.44871893
5* Recurrent fungal infections (HP:0002841)4.13751588
6Panhypogammaglobulinemia (HP:0003139)4.05259051
7Elevated erythrocyte sedimentation rate (HP:0003565)4.03108592
8Cellulitis (HP:0100658)4.01776158
9IgM deficiency (HP:0002850)3.96700700
10Gastrointestinal infarctions (HP:0005244)3.94802533
11T lymphocytopenia (HP:0005403)3.93184294
12Chronic otitis media (HP:0000389)3.92190512
13Agammaglobulinemia (HP:0004432)3.90426428
14Abnormality of T cell number (HP:0011839)3.73197525
15Myositis (HP:0100614)3.70449071
16Meningitis (HP:0001287)3.65921928
17Thyroiditis (HP:0100646)3.62169457
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.56599222
19Keratoconjunctivitis sicca (HP:0001097)3.56563641
20B lymphocytopenia (HP:0010976)3.53064064
21Abnormality of B cell number (HP:0010975)3.53064064
22Recurrent bronchitis (HP:0002837)3.47710546
23Mediastinal lymphadenopathy (HP:0100721)3.34944229
24Recurrent gram-negative bacterial infections (HP:0005420)3.33982877
25Keratoconjunctivitis (HP:0001096)3.31521593
26Abnormality of the fingertips (HP:0001211)3.31502210
27Inflammation of the large intestine (HP:0002037)3.26843497
28Abnormality of T cells (HP:0002843)3.24809233
29Prolonged bleeding time (HP:0003010)3.19170978
30Stomatitis (HP:0010280)3.17959366
31Gastrointestinal inflammation (HP:0004386)3.14319169
32Eosinophilia (HP:0001880)3.13903943
33Pustule (HP:0200039)3.08407552
34Colitis (HP:0002583)3.05437424
35* Recurrent skin infections (HP:0001581)3.01308413
36Vasculitis (HP:0002633)3.00951073
37Abnormality of liposaccharide metabolism (HP:0010968)2.98984821
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.98984821
39Abnormality of glycolipid metabolism (HP:0010969)2.98984821
40Lymphopenia (HP:0001888)2.96456549
41Autoimmune thrombocytopenia (HP:0001973)2.95413004
42Obstructive lung disease (HP:0006536)2.95049367
43Chronic obstructive pulmonary disease (HP:0006510)2.95049367
44Severe combined immunodeficiency (HP:0004430)2.91950953
45Spontaneous hematomas (HP:0007420)2.91439244
46Amyloidosis (HP:0011034)2.90385636
47Hypochromic microcytic anemia (HP:0004840)2.90120197
48Increased cerebral lipofuscin (HP:0011813)2.87886339
49Leukocytosis (HP:0001974)2.87377862
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.85478088
51Abnormality of macrophages (HP:0004311)2.84656408
52Papilloma (HP:0012740)2.84115813
53Verrucae (HP:0200043)2.84115813
54Osteomyelitis (HP:0002754)2.82714595
55Hypochromic anemia (HP:0001931)2.79286481
56Episodic fever (HP:0001954)2.75597773
57Granulocytopenia (HP:0001913)2.74973612
58Peritonitis (HP:0002586)2.73935133
59Combined immunodeficiency (HP:0005387)2.70891461
60Abnormality of eosinophils (HP:0001879)2.70697951
61Gastrointestinal stroma tumor (HP:0100723)2.69705179
62* Hemoptysis (HP:0002105)2.69493250
63Abnormality of T cell physiology (HP:0011840)2.68837620
64IgG deficiency (HP:0004315)2.67757926
65Epistaxis (HP:0000421)2.65589775
66Chronic diarrhea (HP:0002028)2.63954616
67Nasal polyposis (HP:0100582)2.63781306
68Gingival bleeding (HP:0000225)2.60397085
69Periodontitis (HP:0000704)2.60185879
70Abnormal platelet function (HP:0011869)2.55816195
71Impaired platelet aggregation (HP:0003540)2.55816195
72Thrombocytosis (HP:0001894)2.55747253
73Petechiae (HP:0000967)2.55292500
74Gingivitis (HP:0000230)2.54133114
75Pulmonary embolism (HP:0002204)2.52476099
76Anorexia (HP:0002039)2.52160819
77Recurrent sinusitis (HP:0011108)2.52071271
78Increased IgE level (HP:0003212)2.49012420
79Orchitis (HP:0100796)2.46907866
80* Recurrent cutaneous fungal infections (HP:0011370)2.44970618
81* Chronic mucocutaneous candidiasis (HP:0002728)2.44970618
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43825588
83Interstitial pulmonary disease (HP:0006530)2.43479391
84Recurrent pneumonia (HP:0006532)2.42939863
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.42819236
86Hypoplasia of the thymus (HP:0000778)2.41867125
87Retrobulbar optic neuritis (HP:0100654)2.35261491
88Optic neuritis (HP:0100653)2.35261491
89Loss of speech (HP:0002371)2.33642012
90Dysostosis multiplex (HP:0000943)2.32206236
91Abnormality of the nasal mucosa (HP:0000433)2.31501458
92Chronic sinusitis (HP:0011109)2.30620659
93Arterial thrombosis (HP:0004420)2.26354252
94Lymphoma (HP:0002665)2.25953421
95Recurrent lower respiratory tract infections (HP:0002783)2.25925275
96Encephalitis (HP:0002383)2.24202460
97Hematochezia (HP:0002573)2.22169016
98Microcytic anemia (HP:0001935)2.21883174
99Sepsis (HP:0100806)2.20895545
100Emphysema (HP:0002097)2.19236041
101Abnormality of the pleura (HP:0002103)2.16352600
102Purpura (HP:0000979)2.16254327
103Increased IgM level (HP:0003496)2.15116702
104Gangrene (HP:0100758)2.12544041
105Acute myeloid leukemia (HP:0004808)2.12439816
106Abnormality of the prostate (HP:0008775)2.11544534
107Abnormality of the peritoneum (HP:0002585)2.11538131
108IgA deficiency (HP:0002720)2.08627433
109Pulmonary infiltrates (HP:0002113)2.08452228
110Systemic lupus erythematosus (HP:0002725)2.08173399
111Slow saccadic eye movements (HP:0000514)2.04227550
112Increased serum ferritin (HP:0003281)2.03731280
113Abnormal platelet volume (HP:0011876)2.02630594
114Hypergammaglobulinemia (HP:0010702)2.02417312
115Glomerulopathy (HP:0100820)1.99600198
116Urticaria (HP:0001025)1.98052049
117Hepatosplenomegaly (HP:0001433)1.97660538
118* Skin ulcer (HP:0200042)1.95811966
119Vertigo (HP:0002321)1.95079044
120Restrictive lung disease (HP:0002091)1.95068011
121Chest pain (HP:0100749)1.94844614
122Premature loss of primary teeth (HP:0006323)1.94473305
123Viral hepatitis (HP:0006562)1.92649164
124Abnormality of iron homeostasis (HP:0011031)1.92164355
125Acne (HP:0001061)1.89663254
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88925040
127Abnormality of polysaccharide metabolism (HP:0011012)1.88925040
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88925040
129Prostate neoplasm (HP:0100787)1.87127649
130Leukopenia (HP:0001882)1.86923773
131Keratitis (HP:0000491)1.85446499
132Polyneuropathy (HP:0001271)1.85271640
133Menorrhagia (HP:0000132)1.84878030
134Entropion (HP:0000621)1.84693819
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83207673
136Abnormality of the pericardium (HP:0001697)1.81854872
137Increased density of long bones (HP:0006392)1.79132011
138Acute lymphatic leukemia (HP:0006721)1.79091679
139Bronchitis (HP:0012387)1.78318593
140Vacuolated lymphocytes (HP:0001922)1.78235173
141Myocardial infarction (HP:0001658)1.77205184
142Spinal cord lesions (HP:0100561)1.74735664
143Syringomyelia (HP:0003396)1.74735664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.75621580
2TXK2.99345326
3PRPF4B2.55320759
4MAP3K102.40409338
5STK102.38370681
6EEF2K2.28058673
7TGFBR22.26077104
8TYK22.24390791
9ZAP702.19093272
10IRAK42.18252351
11JAK32.15200877
12KIT2.14829574
13BTK2.14152276
14ITK2.05327737
15TEC2.03914467
16MAP3K141.96922596
17GRK61.94532709
18CDK121.93078846
19ERN11.92616330
20TBK11.85350527
21BLK1.84116141
22CSF1R1.78683128
23FGR1.73283084
24SYK1.71468919
25IKBKE1.64387674
26SIK21.63572547
27RIPK41.62603278
28HCK1.54273018
29MAP3K131.53704268
30JAK11.53627060
31CSK1.45959636
32FLT31.40126397
33FES1.38400946
34MAP2K31.38154360
35RPS6KA41.37483178
36TAOK31.36760492
37IKBKB1.36129536
38LCK1.36045393
39IRAK31.34755281
40NLK1.33203054
41MAP3K111.33128752
42CLK11.32751844
43MARK31.28718582
44FGFR31.28221427
45MAP3K11.27771692
46FGFR41.27324078
47PIM11.25615951
48EPHB11.25090714
49SIK31.25055065
50PKN21.16840812
51KSR21.16211150
52TRIB31.14293865
53LYN1.12175435
54LRRK21.04875765
55MAP3K60.95781354
56PIK3CG0.95657509
57CAMK1D0.93183674
58IRAK10.92501728
59TAOK20.90130718
60JAK20.86456735
61IRAK20.85255448
62MAP3K20.84580409
63CHUK0.84539344
64BRD40.84246911
65NEK20.83896462
66BMPR20.83445189
67STK40.81998490
68PDPK10.81412072
69CDK40.80071557
70SIK10.76050153
71HIPK20.74741925
72CDC42BPA0.74317803
73TRPM70.71350962
74MAPK70.69720919
75NME20.69430059
76PTK2B0.69257291
77SMG10.69193816
78MAPK40.68800414
79PTK60.65129621
80MAPK110.64959916
81CDK60.63403668
82CAMK1G0.63066343
83MAP3K70.62423539
84SGK30.62405686
85CAMKK20.61792221
86EPHA30.59451964
87GRK70.59076933
88FYN0.57124349
89PRKCQ0.56454814
90PRKCH0.54987525
91MAP3K50.54657443
92MAP2K60.53720030
93STK110.53160817
94MAP2K40.52952025
95RPS6KA60.52498383
96TNK20.52280592
97TESK20.50359398
98CDK90.50339267
99TAOK10.48797775
100RPS6KB20.48186748
101ALK0.47738837
102RET0.47686065
103MAPKAPK20.47665388
104ATR0.47192192
105SGK20.46420466
106NEK90.45844894
107CAMKK10.45282938
108RAF10.44854544
109RPS6KC10.42641206
110RPS6KL10.42641206
111PIM20.42345734
112MAP3K30.40989264
113MAPK120.40709219
114MATK0.40153099
115WNK10.40020206
116MAP3K80.38507599
117PDK10.37701839
118YES10.37658408
119MELK0.37443040
120STK380.37305805
121MARK20.36561030
122PDGFRB0.36558009
123KSR10.36316072
124PRKD20.35662091
125ABL10.35586649
126EGFR0.34086377
127DAPK20.34026294
128ADRBK20.34020503
129TTN0.34011601
130KDR0.33410414
131RPS6KA20.33154318
132CDK70.31158374
133NUAK10.30785354
134MAPK30.30137250

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.86203126
2B cell receptor signaling pathway_Homo sapiens_hsa046622.87788932
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.67938713
4Leishmaniasis_Homo sapiens_hsa051402.66513583
5Osteoclast differentiation_Homo sapiens_hsa043802.50605156
6Hematopoietic cell lineage_Homo sapiens_hsa046402.25319772
7Measles_Homo sapiens_hsa051622.22004471
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12646956
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.11809548
10T cell receptor signaling pathway_Homo sapiens_hsa046602.04695110
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00560394
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90645462
13Antigen processing and presentation_Homo sapiens_hsa046121.84364115
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75577610
15Acute myeloid leukemia_Homo sapiens_hsa052211.73426999
16Staphylococcus aureus infection_Homo sapiens_hsa051501.72832913
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70936033
18Herpes simplex infection_Homo sapiens_hsa051681.70102396
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67885327
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66346595
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61984254
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.58965445
23Chronic myeloid leukemia_Homo sapiens_hsa052201.54907866
24Hepatitis B_Homo sapiens_hsa051611.51990033
25Toxoplasmosis_Homo sapiens_hsa051451.49694243
26Influenza A_Homo sapiens_hsa051641.46909182
27Phagosome_Homo sapiens_hsa041451.42143579
28Tuberculosis_Homo sapiens_hsa051521.42042779
29Type I diabetes mellitus_Homo sapiens_hsa049401.40280082
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40218865
31TNF signaling pathway_Homo sapiens_hsa046681.39053906
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38953453
33Pertussis_Homo sapiens_hsa051331.38903507
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.36867772
35Chemokine signaling pathway_Homo sapiens_hsa040621.30546760
36Pancreatic cancer_Homo sapiens_hsa052121.29098719
37Non-homologous end-joining_Homo sapiens_hsa034501.28536740
38Shigellosis_Homo sapiens_hsa051311.28329456
39Malaria_Homo sapiens_hsa051441.28242677
40Apoptosis_Homo sapiens_hsa042101.25079774
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24789161
42Legionellosis_Homo sapiens_hsa051341.18680070
43Platelet activation_Homo sapiens_hsa046111.16511732
44Graft-versus-host disease_Homo sapiens_hsa053321.12814263
45DNA replication_Homo sapiens_hsa030301.06285418
46Allograft rejection_Homo sapiens_hsa053301.04627899
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01938256
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99834961
49* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99327883
50Other glycan degradation_Homo sapiens_hsa005110.99127840
51Non-small cell lung cancer_Homo sapiens_hsa052230.98233109
52HTLV-I infection_Homo sapiens_hsa051660.97917382
53Asthma_Homo sapiens_hsa053100.95483580
54Hepatitis C_Homo sapiens_hsa051600.95181099
55Caffeine metabolism_Homo sapiens_hsa002320.94900291
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.93572975
57Epstein-Barr virus infection_Homo sapiens_hsa051690.90746523
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89777169
59Small cell lung cancer_Homo sapiens_hsa052220.89105868
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.88609734
61Viral carcinogenesis_Homo sapiens_hsa052030.87509754
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87498705
63Prolactin signaling pathway_Homo sapiens_hsa049170.85238388
64Viral myocarditis_Homo sapiens_hsa054160.82821445
65Colorectal cancer_Homo sapiens_hsa052100.81726955
66Base excision repair_Homo sapiens_hsa034100.81367727
67Dorso-ventral axis formation_Homo sapiens_hsa043200.80553814
68Salmonella infection_Homo sapiens_hsa051320.80016029
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74389843
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.73072013
71Amoebiasis_Homo sapiens_hsa051460.72160994
72GnRH signaling pathway_Homo sapiens_hsa049120.70860452
73Notch signaling pathway_Homo sapiens_hsa043300.69667870
74FoxO signaling pathway_Homo sapiens_hsa040680.69538335
75MicroRNAs in cancer_Homo sapiens_hsa052060.66852439
76Homologous recombination_Homo sapiens_hsa034400.64800056
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63545190
78Lysosome_Homo sapiens_hsa041420.63128481
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62469099
80p53 signaling pathway_Homo sapiens_hsa041150.61768685
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60869386
82Choline metabolism in cancer_Homo sapiens_hsa052310.60109792
83Lysine degradation_Homo sapiens_hsa003100.59385434
84VEGF signaling pathway_Homo sapiens_hsa043700.58415553
85Prostate cancer_Homo sapiens_hsa052150.58289582
86Insulin resistance_Homo sapiens_hsa049310.56509711
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54587920
88Type II diabetes mellitus_Homo sapiens_hsa049300.53018526
89Mismatch repair_Homo sapiens_hsa034300.51635614
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51274023
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51000633
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49356063
93African trypanosomiasis_Homo sapiens_hsa051430.47521062
94Fanconi anemia pathway_Homo sapiens_hsa034600.46967244
95Rheumatoid arthritis_Homo sapiens_hsa053230.46942664
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46196536
97Inositol phosphate metabolism_Homo sapiens_hsa005620.44936590
98Cell cycle_Homo sapiens_hsa041100.44904434
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.44575985
100ABC transporters_Homo sapiens_hsa020100.44545560
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.43494361
102Rap1 signaling pathway_Homo sapiens_hsa040150.43319487
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43002618
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42645924
105ErbB signaling pathway_Homo sapiens_hsa040120.42289134
106Estrogen signaling pathway_Homo sapiens_hsa049150.41580297
107mTOR signaling pathway_Homo sapiens_hsa041500.40521608
108HIF-1 signaling pathway_Homo sapiens_hsa040660.40103828
109Spliceosome_Homo sapiens_hsa030400.39833663
110Regulation of autophagy_Homo sapiens_hsa041400.39121092
111Renal cell carcinoma_Homo sapiens_hsa052110.37452926
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37284351
113MAPK signaling pathway_Homo sapiens_hsa040100.36842961
114Autoimmune thyroid disease_Homo sapiens_hsa053200.35150382
115Pathways in cancer_Homo sapiens_hsa052000.34847609
116Endometrial cancer_Homo sapiens_hsa052130.34770948
117Proteoglycans in cancer_Homo sapiens_hsa052050.34492076
118Glioma_Homo sapiens_hsa052140.34379004
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.34301315
120Endocytosis_Homo sapiens_hsa041440.32987775
121Systemic lupus erythematosus_Homo sapiens_hsa053220.31397516

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