IL17RB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of regulatory T cell differentiation (GO:0045589)9.64908071
2negative regulation of B cell proliferation (GO:0030889)9.63502820
3regulation of cytokine secretion involved in immune response (GO:0002739)8.49201428
4regulation of MHC class II biosynthetic process (GO:0045346)8.27779845
5negative regulation of nitric oxide biosynthetic process (GO:0045019)7.44657227
6branching involved in labyrinthine layer morphogenesis (GO:0060670)6.99395451
7negative regulation of fibrinolysis (GO:0051918)6.93343644
8response to inactivity (GO:0014854)6.75031819
9regulation of fibrinolysis (GO:0051917)6.42861070
10negative regulation of interleukin-12 production (GO:0032695)6.20430058
11negative regulation of inflammatory response to antigenic stimulus (GO:0002862)6.17960623
12regulation of protein activation cascade (GO:2000257)6.02910596
13regulation of complement activation (GO:0030449)5.81631927
14regulation of plasminogen activation (GO:0010755)5.79486282
15negative regulation of B cell activation (GO:0050869)5.64722904
16low-density lipoprotein particle remodeling (GO:0034374)5.63021616
17regulation of cholesterol esterification (GO:0010872)5.57129662
18very-low-density lipoprotein particle assembly (GO:0034379)5.54059346
19plasma lipoprotein particle remodeling (GO:0034369)5.34446419
20protein-lipid complex remodeling (GO:0034368)5.34446419
21macromolecular complex remodeling (GO:0034367)5.34446419
22regulation of tumor necrosis factor biosynthetic process (GO:0042534)5.26345048
23blood coagulation, intrinsic pathway (GO:0007597)5.13199845
24regulation of isotype switching (GO:0045191)5.01934051
25plasma lipoprotein particle assembly (GO:0034377)5.01593004
26tolerance induction (GO:0002507)4.91614394
27intestinal cholesterol absorption (GO:0030299)4.91343507
28regulation of isotype switching to IgG isotypes (GO:0048302)4.88254615
29high-density lipoprotein particle remodeling (GO:0034375)4.83947466
30cholesterol efflux (GO:0033344)4.79287172
31regulation of bile acid biosynthetic process (GO:0070857)4.79261234
32complement activation, alternative pathway (GO:0006957)4.73891918
33negative regulation of cytokine production involved in immune response (GO:0002719)4.61620385
34L-phenylalanine catabolic process (GO:0006559)4.60400016
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.60400016
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.47230716
37response to mercury ion (GO:0046689)4.44971000
38reverse cholesterol transport (GO:0043691)4.44044422
39plasma lipoprotein particle organization (GO:0071827)4.42807173
40protein-lipid complex assembly (GO:0065005)4.33981628
41serine family amino acid catabolic process (GO:0009071)4.31905717
42plasma lipoprotein particle clearance (GO:0034381)4.29800094
43regulation of B cell proliferation (GO:0030888)4.29723346
44negative regulation of NF-kappaB import into nucleus (GO:0042347)4.28385270
45negative regulation of T-helper cell differentiation (GO:0045623)4.24795528
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.24795528
47acylglycerol homeostasis (GO:0055090)4.20492411
48triglyceride homeostasis (GO:0070328)4.20492411
49glial cell proliferation (GO:0014009)4.20153329
50L-phenylalanine metabolic process (GO:0006558)4.13965861
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.13965861
52regulation of interferon-alpha production (GO:0032647)4.13424066
53cellular response to interleukin-15 (GO:0071350)4.11274272
54epoxygenase P450 pathway (GO:0019373)4.10605623
55protein-lipid complex subunit organization (GO:0071825)4.09491018
56regulation of immunoglobulin production (GO:0002637)4.08009646
57T-helper cell differentiation (GO:0042093)4.07261531
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.07261531
59lymphocyte costimulation (GO:0031294)4.04487040
60regulation of cholesterol homeostasis (GO:2000188)4.04469583
61regulation of membrane protein ectodomain proteolysis (GO:0051043)4.02222620
62negative regulation of production of molecular mediator of immune response (GO:0002701)3.98793338
63exogenous drug catabolic process (GO:0042738)3.97580003
64regulation of apoptotic cell clearance (GO:2000425)3.97206612
65negative regulation of cell killing (GO:0031342)3.96361271
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96361271
67negative regulation of T cell proliferation (GO:0042130)3.95214084
68proline metabolic process (GO:0006560)3.94730688
69positive regulation of lymphocyte apoptotic process (GO:0070230)3.94428090
70negative regulation of acute inflammatory response (GO:0002674)3.93159208
71response to interleukin-15 (GO:0070672)3.91659296
72positive regulation of fatty acid biosynthetic process (GO:0045723)3.91498566
73phospholipid efflux (GO:0033700)3.87387135
74glutamate metabolic process (GO:0006536)3.85610551
75negative regulation of protein activation cascade (GO:2000258)3.81664487
76drug catabolic process (GO:0042737)3.76961762
77negative regulation of growth of symbiont in host (GO:0044130)3.73322794
78negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.73322794
79modulation of growth of symbiont involved in interaction with host (GO:0044144)3.73322794
80regulation of growth of symbiont in host (GO:0044126)3.73322794
81aromatic amino acid family catabolic process (GO:0009074)3.69899356
82homocysteine metabolic process (GO:0050667)3.69448962
83leukocyte aggregation (GO:0070486)3.67363005
84negative regulation of T cell differentiation (GO:0045581)3.67104693
85lipoprotein metabolic process (GO:0042157)3.66536482
86negative T cell selection (GO:0043383)3.62717740
87cysteine metabolic process (GO:0006534)3.61122226
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.60415409
89T cell costimulation (GO:0031295)3.59929890
90protein activation cascade (GO:0072376)3.59834428
91regulation of cholesterol biosynthetic process (GO:0045540)3.59651692
92cellular glucuronidation (GO:0052695)3.58493777
93bile acid metabolic process (GO:0008206)3.57080157
94fibrinolysis (GO:0042730)3.56397850
95regulation of humoral immune response (GO:0002920)3.55708803
96regulation of inflammatory response to antigenic stimulus (GO:0002861)3.54272704
97negative thymic T cell selection (GO:0045060)3.54183624
98regulation of B cell apoptotic process (GO:0002902)3.50315417
99intestinal absorption (GO:0050892)3.48354764
100lipoprotein transport (GO:0042953)3.47804510
101regulation of immunoglobulin mediated immune response (GO:0002889)3.46843386
102T cell differentiation involved in immune response (GO:0002292)3.45950434
103alpha-beta T cell differentiation involved in immune response (GO:0002293)3.45950434
104alpha-beta T cell activation involved in immune response (GO:0002287)3.45950434
105regulation of cholesterol metabolic process (GO:0090181)3.44930776
106ethanol oxidation (GO:0006069)3.43933754
107complement activation, classical pathway (GO:0006958)3.43558052
108T cell lineage commitment (GO:0002360)3.40392943
109cytoplasmic sequestering of transcription factor (GO:0042994)3.40063224
110regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.39597142
111acute-phase response (GO:0006953)3.39037834
112positive regulation of lipoprotein lipase activity (GO:0051006)3.37770528
113positive regulation of triglyceride lipase activity (GO:0061365)3.37770528
114urea metabolic process (GO:0019627)3.37527903
115uronic acid metabolic process (GO:0006063)3.36662471
116glucuronate metabolic process (GO:0019585)3.36662471
117regulation of proton transport (GO:0010155)3.36328659
118regulation of interleukin-13 production (GO:0032656)3.35624519
119regulation of B cell mediated immunity (GO:0002712)3.35009140
120negative regulation of hemostasis (GO:1900047)3.34383961
121negative regulation of blood coagulation (GO:0030195)3.34383961
122negative regulation of lymphocyte proliferation (GO:0050672)3.34136366
123negative regulation of mononuclear cell proliferation (GO:0032945)3.34136366
124positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.33827506
125dicarboxylic acid biosynthetic process (GO:0043650)3.33108285
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.32924119
127cholesterol homeostasis (GO:0042632)3.32146838
128response to vitamin A (GO:0033189)3.31734976
129S-adenosylmethionine metabolic process (GO:0046500)3.30415363
130negative regulation of interferon-gamma production (GO:0032689)3.30172794
131positive thymic T cell selection (GO:0045059)3.29867578
132sterol homeostasis (GO:0055092)3.28255511
133negative regulation of leukocyte proliferation (GO:0070664)3.27713270
134alpha-amino acid catabolic process (GO:1901606)3.24149936
135alpha-linolenic acid metabolic process (GO:0036109)3.23817120
136omega-hydroxylase P450 pathway (GO:0097267)3.22586769
137peptidyl-threonine dephosphorylation (GO:0035970)3.21823490
138glycine metabolic process (GO:0006544)3.21274108
139negative regulation of T cell activation (GO:0050868)3.20042471
140mammary gland alveolus development (GO:0060749)3.19460031
141urea cycle (GO:0000050)3.18271901
142bile acid biosynthetic process (GO:0006699)3.16793222
143lipid homeostasis (GO:0055088)3.15794072
144thymic T cell selection (GO:0045061)3.13895332
145regulation of cholesterol storage (GO:0010885)3.13486871
146COPII vesicle coating (GO:0048208)3.13205718
147tyrosine phosphorylation of STAT protein (GO:0007260)3.12811622
148negative regulation of complement activation (GO:0045916)3.09736687
149positive regulation of steroid metabolic process (GO:0045940)3.09635551
150drug transmembrane transport (GO:0006855)3.09184054
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08458246
152growth hormone receptor signaling pathway (GO:0060396)3.08348462
153sulfur amino acid catabolic process (GO:0000098)3.08146703
154serine family amino acid biosynthetic process (GO:0009070)3.07204856
1554-hydroxyproline metabolic process (GO:0019471)3.06757916
156glyoxylate metabolic process (GO:0046487)3.06550139
157kynurenine metabolic process (GO:0070189)3.06371887
158regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03478697
159regulation of mitotic spindle checkpoint (GO:1903504)3.03478697
160negative regulation of cytokine biosynthetic process (GO:0042036)3.01272290
161negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00723060
162negative regulation of adaptive immune response (GO:0002820)3.00664852
163nitrogen cycle metabolic process (GO:0071941)3.00554960
164regulation of triglyceride catabolic process (GO:0010896)3.00416796
165ethanol metabolic process (GO:0006067)2.98541336
166B cell proliferation (GO:0042100)2.97850763
167positive T cell selection (GO:0043368)2.96929352
168regulation of lipoprotein metabolic process (GO:0050746)2.96848305
169negative regulation of coagulation (GO:0050819)2.96696944
170imidazole-containing compound metabolic process (GO:0052803)2.94511806
171peptidyl-glutamic acid carboxylation (GO:0017187)2.93036504
172protein carboxylation (GO:0018214)2.93036504
173regulation of B cell activation (GO:0050864)2.92680729
174T cell receptor signaling pathway (GO:0050852)2.92451205
175amino-acid betaine metabolic process (GO:0006577)2.91627334
176T cell selection (GO:0045058)2.91144020
177negative regulation of sterol transport (GO:0032372)2.90706796
178negative regulation of cholesterol transport (GO:0032375)2.90706796
179triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90522933
180thyroid hormone generation (GO:0006590)2.90444608
181tryptophan catabolic process (GO:0006569)2.89771431
182indole-containing compound catabolic process (GO:0042436)2.89771431
183indolalkylamine catabolic process (GO:0046218)2.89771431
184CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.87420688
185negative regulation of immune response (GO:0050777)2.87031776
186regulation of chronic inflammatory response (GO:0002676)10.1904696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.68400416
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.48350950
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.91682558
4ESR1_15608294_ChIP-ChIP_MCF-7_Human4.84079904
5RXR_22158963_ChIP-Seq_LIVER_Mouse4.40219341
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.76914005
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.54135036
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.54047831
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.46126545
10RUNX_20019798_ChIP-Seq_JUKART_Human3.41973270
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63868841
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.63277862
13MYB_26560356_Chip-Seq_TH2_Human2.62242808
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.55700791
15HNF4A_19822575_ChIP-Seq_HepG2_Human2.48840455
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.46757721
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43382043
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40187680
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.39052974
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.38865409
21GATA1_22025678_ChIP-Seq_K562_Human2.37129794
22ZNF263_19887448_ChIP-Seq_K562_Human2.36925905
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35598295
24* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23460470
25MAF_26560356_Chip-Seq_TH1_Human2.13490722
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12712356
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11029562
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.05503259
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05062225
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03276865
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01534407
32SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.90663168
33SCL_19346495_ChIP-Seq_HPC-7_Human1.85853441
34MYB_26560356_Chip-Seq_TH1_Human1.85170192
35GATA4_25053715_ChIP-Seq_YYC3_Human1.82056031
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75839500
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75756346
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75540277
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75188176
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.69252453
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68902972
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68797678
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66941731
44HTT_18923047_ChIP-ChIP_STHdh_Human1.62344319
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62066613
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60289126
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59128904
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57343183
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55645991
50UTX_26944678_Chip-Seq_JUKART_Human1.50874782
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48849558
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46724900
53GATA1_19941826_ChIP-Seq_K562_Human1.44068874
54GATA3_26560356_Chip-Seq_TH2_Human1.43939144
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.41927931
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.41786817
57GATA3_27048872_Chip-Seq_THYMUS_Human1.41491149
58GATA6_25053715_ChIP-Seq_YYC3_Human1.39175394
59PU_27001747_Chip-Seq_BMDM_Mouse1.36585792
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30139357
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.29994498
62IRF1_19129219_ChIP-ChIP_H3396_Human1.29973846
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.28022643
64* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25919472
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25700529
66EGR1_19032775_ChIP-ChIP_M12_Human1.23674443
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21832236
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20820714
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20538491
70GATA2_19941826_ChIP-Seq_K562_Human1.20138815
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.16285938
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.16214694
73RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11255678
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10439924
75GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08616309
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07954169
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.07291662
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07096514
79AR_21909140_ChIP-Seq_LNCAP_Human1.06916689
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06656744
81MAF_26560356_Chip-Seq_TH2_Human1.06502264
82* P68_20966046_ChIP-Seq_HELA_Human1.05256201
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05124242
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05081587
85* ESR1_21235772_ChIP-Seq_MCF-7_Human1.04690717
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03730540
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.03177091
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.00721330
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.98084815
90* RUNX1_22412390_ChIP-Seq_EML_Mouse0.97436146
91ETS1_21867929_ChIP-Seq_TH2_Mouse0.97360428
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96322695
93* ESR2_21235772_ChIP-Seq_MCF-7_Human0.96262805
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95808208
95AR_21572438_ChIP-Seq_LNCaP_Human0.95577241
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.95565419
97VDR_21846776_ChIP-Seq_THP-1_Human0.93448805
98VDR_22108803_ChIP-Seq_LS180_Human0.93258218
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91482505
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91344207
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.91156165
102TCF7_22412390_ChIP-Seq_EML_Mouse0.90930939
103NFE2_27457419_Chip-Seq_LIVER_Mouse0.89412374
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89218800
105BCOR_27268052_Chip-Seq_Bcells_Human0.89211135
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88485107
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88347152
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88116633
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87233164
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86581934
111EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86581348
112VDR_24763502_ChIP-Seq_THP-1_Human0.86275759
113FOXH1_21741376_ChIP-Seq_ESCs_Human0.86265023
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85713637
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85645721
116VDR_24787735_ChIP-Seq_THP-1_Human0.85048536
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84884673
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84843171
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.84418902
120STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.84289765
121GATA3_26560356_Chip-Seq_TH1_Human0.84270161
122CLOCK_20551151_ChIP-Seq_293T_Human0.83148171
123PHF8_20622854_ChIP-Seq_HELA_Human0.82664510
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80065248
125TAF15_26573619_Chip-Seq_HEK293_Human0.79595469
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78786461
127CEBPB_22108803_ChIP-Seq_LS180_Human0.78776762
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78507303
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78504299
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77727279
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77444523
132GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76976435
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76365482
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75961121
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.75690041
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.74947257
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74456199
138E2F1_20622854_ChIP-Seq_HELA_Human0.74303554
139LXR_22292898_ChIP-Seq_THP-1_Human0.74030325
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73406394
141SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.73157106
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73100016
143SMC4_20622854_ChIP-Seq_HELA_Human0.72715638
144CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72698226
145PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72674545
146P300_27268052_Chip-Seq_Bcells_Human0.72100475
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71948701
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71896145
149SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71407045
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71244226
151MYC_22102868_ChIP-Seq_BL_Human0.71147913
152RARA_24833708_ChIP-Seq_LIVER_Mouse0.70782530
153SPI1_23127762_ChIP-Seq_K562_Human0.69544640
154SPI1_23547873_ChIP-Seq_NB4_Human0.69185658
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68218455
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67541367
157ELF1_17652178_ChIP-ChIP_JURKAT_Human0.67480285
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66638721
159MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.66273588
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66161791
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65183712
162GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64646470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.92732651
2MP0001873_stomach_inflammation5.45215873
3MP0003300_gastrointestinal_ulcer5.13051479
4MP0005671_abnormal_response_to3.90881898
5MP0001853_heart_inflammation3.53311494
6MP0005360_urolithiasis3.34340295
7MP0002139_abnormal_hepatobiliary_system3.18993031
8MP0005310_abnormal_salivary_gland3.12945575
9MP0003763_abnormal_thymus_physiology2.93756913
10MP0006082_CNS_inflammation2.78193817
11MP0001835_abnormal_antigen_presentation2.60492974
12MP0005365_abnormal_bile_salt2.51862083
13MP0002933_joint_inflammation2.46250292
14MP0003724_increased_susceptibility_to2.44224309
15MP0008875_abnormal_xenobiotic_pharmacok2.42185099
16MP0005085_abnormal_gallbladder_physiolo2.33139471
17MP0005387_immune_system_phenotype2.21429461
18MP0001790_abnormal_immune_system2.21429461
19MP0003122_maternal_imprinting2.17948038
20MP0001663_abnormal_digestive_system2.08321949
21MP0001348_abnormal_lacrimal_gland2.06116763
22MP0003806_abnormal_nucleotide_metabolis2.03175612
23MP0004947_skin_inflammation1.94307758
24* MP0001800_abnormal_humoral_immune1.88780910
25MP0001661_extended_life_span1.85877529
26MP0005646_abnormal_pituitary_gland1.85682369
27MP0001542_abnormal_bone_strength1.83939234
28MP0005000_abnormal_immune_tolerance1.79777335
29MP0003252_abnormal_bile_duct1.77732351
30MP0002009_preneoplasia1.77532543
31MP0001986_abnormal_taste_sensitivity1.67121108
32MP0005670_abnormal_white_adipose1.66981314
33MP0001764_abnormal_homeostasis1.66675221
34MP0010155_abnormal_intestine_physiology1.65955454
35MP0000566_synostosis1.64372214
36MP0004264_abnormal_extraembryonic_tissu1.61683843
37MP0003880_abnormal_central_pattern1.61383241
38MP0003950_abnormal_plasma_membrane1.60083402
39MP0002332_abnormal_exercise_endurance1.59353581
40MP0005381_digestive/alimentary_phenotyp1.59267415
41MP0002876_abnormal_thyroid_physiology1.57894303
42MP0000465_gastrointestinal_hemorrhage1.56520130
43MP0002909_abnormal_adrenal_gland1.55914405
44MP0009785_altered_susceptibility_to1.52465234
45MP0003879_abnormal_hair_cell1.51734533
46MP0001919_abnormal_reproductive_system1.51576132
47MP0005332_abnormal_amino_acid1.50257458
48* MP0005025_abnormal_response_to1.49591938
49MP0000013_abnormal_adipose_tissue1.49175582
50* MP0002723_abnormal_immune_serum1.48057070
51MP0000003_abnormal_adipose_tissue1.44431407
52MP0000490_abnormal_crypts_of1.42451775
53MP0002405_respiratory_system_inflammati1.42156991
54MP0002166_altered_tumor_susceptibility1.40096323
55MP0009840_abnormal_foam_cell1.35391137
56MP0003075_altered_response_to1.34384364
57MP0004381_abnormal_hair_follicle1.26986720
58MP0001501_abnormal_sleep_pattern1.26919769
59MP0004510_myositis1.24545734
60MP0000383_abnormal_hair_follicle1.21813578
61* MP0002452_abnormal_antigen_presenting1.21720846
62MP0003436_decreased_susceptibility_to1.20640812
63MP0001533_abnormal_skeleton_physiology1.19656060
64MP0001666_abnormal_nutrient_absorption1.19121643
65MP0002089_abnormal_postnatal_growth/wei1.18813264
66* MP0001819_abnormal_immune_cell1.17686902
67MP0000609_abnormal_liver_physiology1.17412893
68* MP0002420_abnormal_adaptive_immunity1.17288775
69MP0005165_increased_susceptibility_to1.16955695
70MP0005023_abnormal_wound_healing1.15980093
71* MP0001845_abnormal_inflammatory_respons1.15711560
72MP0008469_abnormal_protein_level1.15103760
73* MP0000716_abnormal_immune_system1.12047684
74MP0000685_abnormal_immune_system1.11718700
75MP0005257_abnormal_intraocular_pressure1.11490006
76MP0000703_abnormal_thymus_morphology1.11381047
77MP0010329_abnormal_lipoprotein_level1.10415953
78MP0003868_abnormal_feces_composition1.10380581
79* MP0002398_abnormal_bone_marrow1.09822873
80MP0009697_abnormal_copulation1.08402977
81MP0002148_abnormal_hypersensitivity_rea1.06360870
82MP0005584_abnormal_enzyme/coenzyme_acti1.05352485
83MP0003123_paternal_imprinting1.04785823
84MP0005408_hypopigmentation1.03657231
85MP0002722_abnormal_immune_system1.01624451
86MP0009763_increased_sensitivity_to1.00872874
87MP0010678_abnormal_skin_adnexa1.00786176
88MP0008872_abnormal_physiological_respon1.00631675
89MP0003866_abnormal_defecation1.00378633
90MP0005076_abnormal_cell_differentiation0.99224710
91MP0005319_abnormal_enzyme/_coenzyme0.98996837
92MP0005377_hearing/vestibular/ear_phenot0.98540422
93MP0003878_abnormal_ear_physiology0.98540422
94MP0002419_abnormal_innate_immunity0.97309868
95MP0002396_abnormal_hematopoietic_system0.96958320
96MP0001881_abnormal_mammary_gland0.96710938
97MP0009333_abnormal_splenocyte_physiolog0.95625637
98MP0005167_abnormal_blood-brain_barrier0.95544392
99MP0002118_abnormal_lipid_homeostasis0.94178080
100MP0003183_abnormal_peptide_metabolism0.93248533
101MP0000920_abnormal_myelination0.92487809
102MP0000343_altered_response_to0.92325847
103MP0005451_abnormal_body_composition0.89822283
104MP0003656_abnormal_erythrocyte_physiolo0.89357295
105MP0009780_abnormal_chondrocyte_physiolo0.88403001
106MP0000477_abnormal_intestine_morphology0.88329200
107MP0002138_abnormal_hepatobiliary_system0.87692804
108MP0002006_tumorigenesis0.87623521
109MP0004043_abnormal_pH_regulation0.87193730
110MP0005636_abnormal_mineral_homeostasis0.86604150
111MP0005551_abnormal_eye_electrophysiolog0.85466993
112MP0000689_abnormal_spleen_morphology0.85101924
113MP0005464_abnormal_platelet_physiology0.85084915
114MP0006072_abnormal_retinal_apoptosis0.84645173
115MP0009642_abnormal_blood_homeostasis0.84338701
116MP0003195_calcinosis0.82545138
117MP0004885_abnormal_endolymph0.80434226
118MP0003329_amyloid_beta_deposits0.79059047
119MP0003191_abnormal_cellular_cholesterol0.78370340
120* MP0002429_abnormal_blood_cell0.77775008
121MP0000604_amyloidosis0.77239330
122MP0005389_reproductive_system_phenotype0.76936062
123MP0000249_abnormal_blood_vessel0.76275579
124MP0002078_abnormal_glucose_homeostasis0.75818769
125MP0001851_eye_inflammation0.71894392
126MP0008874_decreased_physiological_sensi0.71371449
127MP0008873_increased_physiological_sensi0.69662617
128MP0002254_reproductive_system_inflammat0.69154966
129MP0009643_abnormal_urine_homeostasis0.68016822
130MP0001765_abnormal_ion_homeostasis0.66036033
131MP0008877_abnormal_DNA_methylation0.65295967
132MP0005083_abnormal_biliary_tract0.64916239
133MP0004130_abnormal_muscle_cell0.64537027
134MP0009046_muscle_twitch0.64080401
135MP0004782_abnormal_surfactant_physiolog0.63988164
136MP0002136_abnormal_kidney_physiology0.62599908
137MP0004019_abnormal_vitamin_homeostasis0.61369822
138MP0000598_abnormal_liver_morphology0.61355371
139MP0003638_abnormal_response/metabolism_0.61346485
140MP0002098_abnormal_vibrissa_morphology0.60739660
141MP0000627_abnormal_mammary_gland0.60258351
142MP0005220_abnormal_exocrine_pancreas0.59650349
143MP0002971_abnormal_brown_adipose0.59276150
144MP0003953_abnormal_hormone_level0.58490621
145MP0003943_abnormal_hepatobiliary_system0.58425487
146MP0004185_abnormal_adipocyte_glucose0.57720097
147MP0004742_abnormal_vestibular_system0.56834947
148MP0003632_abnormal_nervous_system0.56622759
149MP0000639_abnormal_adrenal_gland0.54381961
150MP0010368_abnormal_lymphatic_system0.54042738
151MP0002938_white_spotting0.52923307
152MP0005334_abnormal_fat_pad0.50685756
153MP0004147_increased_porphyrin_level0.46620635
154MP0005410_abnormal_fertilization0.45490261
155MP0003718_maternal_effect0.45096260
156MP0004270_analgesia0.44979309

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)8.89313831
2Optic neuritis (HP:0100653)8.89313831
3Orchitis (HP:0100796)7.80951371
4Abnormality of the prostate (HP:0008775)7.02172616
5Gangrene (HP:0100758)6.89017343
6Myositis (HP:0100614)6.70970806
7Pulmonary embolism (HP:0002204)6.43897643
8Keratoconjunctivitis sicca (HP:0001097)5.99256891
9Pulmonary infiltrates (HP:0002113)5.96809128
10Ureteral stenosis (HP:0000071)5.92962168
11Hemoptysis (HP:0002105)5.76630227
12Keratoconjunctivitis (HP:0001096)5.47833978
13Ureteral obstruction (HP:0006000)5.44506086
14Thrombophlebitis (HP:0004418)5.21841136
15Arterial thrombosis (HP:0004420)4.70061559
16Chest pain (HP:0100749)4.52221683
17Vasculitis (HP:0002633)4.42051522
18Pancreatitis (HP:0001733)4.40000220
19Chronic obstructive pulmonary disease (HP:0006510)4.22720313
20Obstructive lung disease (HP:0006536)4.22720313
21Abnormality of the pericardium (HP:0001697)4.19251018
22Glomerulopathy (HP:0100820)4.18964377
23Polyneuropathy (HP:0001271)4.06807979
24Severe combined immunodeficiency (HP:0004430)4.01099478
25Abnormality of complement system (HP:0005339)3.94334197
26Abnormality of carpal bone ossification (HP:0006257)3.88691298
27Glomerulonephritis (HP:0000099)3.85207399
28Abnormal tarsal ossification (HP:0008369)3.84541510
29Abnormality of the pleura (HP:0002103)3.83507669
30Hypercholesterolemia (HP:0003124)3.80502775
31Conjugated hyperbilirubinemia (HP:0002908)3.74154032
32Meningitis (HP:0001287)3.68432485
33Gastrointestinal infarctions (HP:0005244)3.65176013
34Abnormality of male internal genitalia (HP:0000022)3.61701864
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56954396
36Encephalitis (HP:0002383)3.49826226
37Combined immunodeficiency (HP:0005387)3.49707799
38Systemic lupus erythematosus (HP:0002725)3.47555118
39Hypoalphalipoproteinemia (HP:0003233)3.46365941
40Hemorrhage of the eye (HP:0011885)3.45410738
41Anorexia (HP:0002039)3.36252944
42Abnormality of aromatic amino acid family metabolism (HP:0004338)3.27891346
43T lymphocytopenia (HP:0005403)3.18574245
44Deep venous thrombosis (HP:0002625)3.15465873
45Stomach cancer (HP:0012126)3.13774221
46Intrahepatic cholestasis (HP:0001406)3.09350687
47Epistaxis (HP:0000421)3.03369735
48Abnormality of T cell number (HP:0011839)3.01417260
49Prostate neoplasm (HP:0100787)3.00999614
50Abnormality of proline metabolism (HP:0010907)2.90018991
51Hydroxyprolinuria (HP:0003080)2.90018991
52Abnormality of B cell number (HP:0010975)2.87930782
53B lymphocytopenia (HP:0010976)2.87930782
54Gingival bleeding (HP:0000225)2.87387831
55Chromsome breakage (HP:0040012)2.85973736
56Abnormality of cochlea (HP:0000375)2.85174422
57Abnormality of pyrimidine metabolism (HP:0004353)2.84166097
58Pulmonary fibrosis (HP:0002206)2.78703954
59Abnormal hand bone ossification (HP:0010660)2.75367620
60Abnormality of serine family amino acid metabolism (HP:0010894)2.74267546
61Abnormality of glycine metabolism (HP:0010895)2.74267546
62IgM deficiency (HP:0002850)2.73854881
63Abnormal ossification of hand bones (HP:0005921)2.69313909
64Hyperglycinuria (HP:0003108)2.68907153
65Fatigue (HP:0012378)2.68514534
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68507429
67Fat malabsorption (HP:0002630)2.68503132
68Hyperalaninemia (HP:0003348)2.67001002
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67001002
70Abnormality of alanine metabolism (HP:0010916)2.67001002
71Menorrhagia (HP:0000132)2.65724921
72Arthropathy (HP:0003040)2.62940013
73Prolonged partial thromboplastin time (HP:0003645)2.61302995
74Paresthesia (HP:0003401)2.60967604
75Keratitis (HP:0000491)2.59536327
76Xanthomatosis (HP:0000991)2.56541217
77Cerebral ischemia (HP:0002637)2.56276441
78Hypobetalipoproteinemia (HP:0003563)2.53977994
79Retinopathy (HP:0000488)2.50532668
80Elevated erythrocyte sedimentation rate (HP:0003565)2.46345497
81Flat acetabular roof (HP:0003180)2.40997071
82Abnormality of T cells (HP:0002843)2.40854079
83Increased serum pyruvate (HP:0003542)2.40569952
84Conical tooth (HP:0000698)2.37554142
85Restrictive lung disease (HP:0002091)2.37356231
86Small epiphyses (HP:0010585)2.36326507
87Potter facies (HP:0002009)2.33783986
88Facial shape deformation (HP:0011334)2.33783986
89Abnormality of alkaline phosphatase activity (HP:0004379)2.32812260
90Enlarged kidneys (HP:0000105)2.31942815
91Stomatitis (HP:0010280)2.29859775
92Elevated alkaline phosphatase (HP:0003155)2.27988666
93Abnormal enzyme/coenzyme activity (HP:0012379)2.27600536
94Hyperlipoproteinemia (HP:0010980)2.27006401
95Anteriorly placed anus (HP:0001545)2.26704344
96Thyroiditis (HP:0100646)2.25737030
97Acne (HP:0001061)2.24907160
98Eczematoid dermatitis (HP:0000976)2.23913115
99Abnormality of nucleobase metabolism (HP:0010932)2.22646682
100Abnormality of glycolysis (HP:0004366)2.21248064
101Skin rash (HP:0000988)2.19571185
102Hyperglycinemia (HP:0002154)2.17638878
103Panhypogammaglobulinemia (HP:0003139)2.14365744
104Acanthocytosis (HP:0001927)2.12694647
105Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11478762
106IgG deficiency (HP:0004315)2.10394871
107Spontaneous abortion (HP:0005268)2.08885756
108Recurrent bronchitis (HP:0002837)2.07576202
109Cardiovascular calcification (HP:0011915)2.06636515
110Abnormality of the intrinsic pathway (HP:0010989)2.06631420
111Abnormal pupillary function (HP:0007686)2.06287425
112Generalized aminoaciduria (HP:0002909)2.04151206
113Vertigo (HP:0002321)2.02958970
114Abnormality of serum amino acid levels (HP:0003112)2.02440478
115Increased purine levels (HP:0004368)2.01471004
116Hyperuricemia (HP:0002149)2.01471004
117Periorbital edema (HP:0100539)2.00196301
118Morphological abnormality of the inner ear (HP:0011390)2.00102056
119Abnormality of the common coagulation pathway (HP:0010990)1.99488565
120Facial edema (HP:0000282)1.96714777
121Myocardial infarction (HP:0001658)1.96578120
122Abnormal foot bone ossification (HP:0010675)1.96099493
123Joint hemorrhage (HP:0005261)1.95291530
124Abnormality of purine metabolism (HP:0004352)1.94450284
125Metabolic alkalosis (HP:0200114)1.94371272
126Episodic fever (HP:0001954)1.92703910
127IgA deficiency (HP:0002720)1.91179959
128Abnormality of T cell physiology (HP:0011840)1.90753801
129Arthralgia (HP:0002829)1.90384057
130Pancreatic islet-cell hyperplasia (HP:0004510)1.89653629
131Joint swelling (HP:0001386)1.88609962
132Hypoplasia of the thymus (HP:0000778)1.88199366
133Pigmentary retinal degeneration (HP:0001146)1.87890269
134Nephritis (HP:0000123)1.85478120
135Recurrent fungal infections (HP:0002841)1.85161255
136Complement deficiency (HP:0004431)1.84111404
137Gout (HP:0001997)1.83222812
138Toxemia of pregnancy (HP:0100603)1.81180181
139Ketosis (HP:0001946)1.80893248
140Hypolipoproteinemia (HP:0010981)1.80381810
141Delayed CNS myelination (HP:0002188)1.79138608
142Hyperglycemia (HP:0003074)1.79001851
143Hyperammonemia (HP:0001987)1.78139774
144Abnormality of eosinophils (HP:0001879)1.77334678
145Rickets (HP:0002748)1.76980828
146Humeroradial synostosis (HP:0003041)1.76279919
147Synostosis involving the elbow (HP:0003938)1.76279919
148Vascular calcification (HP:0004934)1.76191051
149Abnormality of the endocardium (HP:0004306)1.75857591
150Recurrent gram-negative bacterial infections (HP:0005420)1.75625295
151Hypoglycemic coma (HP:0001325)1.75609160
152Hepatocellular carcinoma (HP:0001402)1.74977014
153Autoimmune thrombocytopenia (HP:0001973)1.74372040
154Esophageal varix (HP:0002040)1.74074743
155Renovascular hypertension (HP:0100817)1.73410268
156Abnormality of methionine metabolism (HP:0010901)1.73341387
157Hematuria (HP:0000790)1.69934613
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69883784
159Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69541821
160Biconcave vertebral bodies (HP:0004586)1.69461620
161Alkalosis (HP:0001948)1.69377915
162Unilateral renal agenesis (HP:0000122)1.67575472
163Chronic otitis media (HP:0000389)1.67573657
164Migraine (HP:0002076)1.66391535
165Hypokalemic alkalosis (HP:0001949)1.65985586
166Purpura (HP:0000979)1.64705935
167Abnormality of sulfur amino acid metabolism (HP:0004339)1.63493423
168Epidermoid cyst (HP:0200040)1.63346447
169Abdominal pain (HP:0002027)1.62229078
170Leukocytosis (HP:0001974)1.60124646
171Aseptic necrosis (HP:0010885)1.58415487
172Peritonitis (HP:0002586)1.57950239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K25.65379072
2CDK83.66588874
3PLK42.93373808
4FGFR42.57886540
5CDK122.43031439
6MAP2K12.38239114
7WNK42.23419431
8MAP4K12.22024327
9TXK14.9582377
10ZAK1.93035327
11ICK1.90855000
12JAK31.88943659
13JAK21.71019579
14JAK11.60382008
15ZAP701.60328300
16ITK1.48735320
17IKBKE1.47745513
18SGK2231.47167010
19SGK4941.47167010
20GRK51.43804718
21PBK1.42726848
22TESK21.41355107
23TYK21.38415879
24MATK1.36078999
25SGK21.33863159
26NTRK11.33701560
27NEK61.27723263
28PKN21.21971537
29EPHB11.21576031
30TEC1.21332834
31TAOK31.21125852
32LCK1.17114006
33FGFR31.17085123
34SGK31.16664516
35DAPK21.15215607
36NTRK31.09356047
37FGFR21.08762097
38TYRO31.06689448
39MAPK111.04470934
40NTRK21.03863156
41EPHA31.03160201
42TLK11.00336231
43MAPKAPK30.95420946
44KIT0.95187489
45MAP3K30.94990600
46TBK10.93975599
47RPS6KB10.93271449
48MAP3K140.91767834
49ERBB20.90600611
50PIM10.87103996
51STK100.87071411
52BLK0.86403900
53SYK0.85879145
54AKT30.80380981
55HCK0.80360249
56BTK0.80145483
57BRD40.79680704
58PDGFRA0.79002778
59SIK20.76240093
60TRIM280.73408419
61RIPK10.73347284
62WNK10.72063246
63PRKCQ0.71778669
64PRKG20.69276268
65STK390.67898831
66KDR0.67812048
67SGK10.67598407
68BCKDK0.64253966
69NEK20.64184834
70EIF2AK20.63789411
71GRK60.63181085
72SIK10.62412409
73FGR0.61953800
74CCNB10.61882526
75PRKAA20.61496710
76CDK70.61021936
77MST40.60358502
78PLK20.60265711
79DAPK10.55511635
80RPS6KA10.55107319
81PRKAA10.52171040
82PDK10.50777102
83CSNK1A1L0.50524172
84MAPKAPK50.50471011
85FYN0.50163836
86IKBKB0.49824426
87MAP2K30.49142149
88CSNK1G30.48893522
89FES0.48547479
90CSK0.48120269
91MAPK40.47421307
92DYRK1B0.46180736
93LRRK20.45513882
94MAP3K90.45468993
95TRIB30.44359074
96PRKCH0.43156119
97MAP2K60.42956789
98PDPK10.42435119
99MAP3K70.42126556
100STK240.42062449
101CDK60.38855479
102LYN0.36732913
103MAP3K120.36406435
104PTK60.35718419
105CSNK1G10.35563262
106GRK10.34432245
107CSF1R0.33988159
108OXSR10.32187811
109CSNK1G20.31736586
110PRKCG0.30184700
111LATS10.29787947
112DMPK0.29131875
113ABL10.28754275
114ERBB40.27863011
115MAP3K130.27508868
116RPS6KA50.27373881
117RPS6KA20.26702771
118RPS6KL10.25829607
119RPS6KC10.25829607
120PIK3CA0.25546557
121HIPK20.25200057
122KSR20.24979273
123PINK10.24504523
124PIK3CG0.23303488
125TNK20.23276822
126ARAF0.23013052
127NUAK10.22897844
128PRKACG0.22454159
129PKN10.22229756
130NME10.21750487
131IRAK40.21506746
132CSNK1D0.21051834
133MST1R0.20646039
134CHUK0.20480150
135IRAK10.20334639
136TAOK10.18392603
137RET0.18159432
138EEF2K0.17606206
139PRKD10.17572071
140BMPR1B0.17248883
141CAMK2G0.16100268
142CDK40.15822264
143PDGFRB0.15677952
144ERN10.15217795
145FGFR10.14956186
146ILK0.14776553
147MAPK30.14639121
148CDK190.14020000
149STK30.13655754
150CDK90.13028451
151RPS6KB20.12855837
152NLK0.12773501
153CLK10.12169183
154ROCK20.11954828
155IGF1R0.11718948
156MARK20.10961821
157TRPM70.10960423
158IRAK20.10449434
159ALK0.10235377
160GSK3A0.10112778

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053207.55129935
2Asthma_Homo sapiens_hsa053106.17943306
3Allograft rejection_Homo sapiens_hsa053305.16990497
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.89930900
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.02919993
6Staphylococcus aureus infection_Homo sapiens_hsa051502.62967475
7T cell receptor signaling pathway_Homo sapiens_hsa046602.44794874
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.39705498
9Primary immunodeficiency_Homo sapiens_hsa053402.29690777
10Nitrogen metabolism_Homo sapiens_hsa009102.16763941
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.15119371
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71540124
13Histidine metabolism_Homo sapiens_hsa003401.71347749
14Leishmaniasis_Homo sapiens_hsa051401.70796465
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64864745
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63787156
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43552558
18Arginine biosynthesis_Homo sapiens_hsa002201.42438126
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38322894
20One carbon pool by folate_Homo sapiens_hsa006701.37872642
21Tryptophan metabolism_Homo sapiens_hsa003801.32850680
22African trypanosomiasis_Homo sapiens_hsa051431.29959598
23Complement and coagulation cascades_Homo sapiens_hsa046101.28812170
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17318894
25Fatty acid degradation_Homo sapiens_hsa000711.15697797
26Hematopoietic cell lineage_Homo sapiens_hsa046401.15553827
27Caffeine metabolism_Homo sapiens_hsa002321.13618088
28Fatty acid elongation_Homo sapiens_hsa000621.05464952
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05337659
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.01295175
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00825447
32Butanoate metabolism_Homo sapiens_hsa006500.91132942
33Malaria_Homo sapiens_hsa051440.90211140
34Peroxisome_Homo sapiens_hsa041460.89367843
35Chemical carcinogenesis_Homo sapiens_hsa052040.89321935
36Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87077242
37Measles_Homo sapiens_hsa051620.86946781
38Steroid biosynthesis_Homo sapiens_hsa001000.84621610
39Other glycan degradation_Homo sapiens_hsa005110.83826852
40PPAR signaling pathway_Homo sapiens_hsa033200.83705293
41Galactose metabolism_Homo sapiens_hsa000520.82313048
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81776634
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81318325
44Fatty acid metabolism_Homo sapiens_hsa012120.80879582
45N-Glycan biosynthesis_Homo sapiens_hsa005100.79191385
46beta-Alanine metabolism_Homo sapiens_hsa004100.78963502
47Sulfur metabolism_Homo sapiens_hsa009200.77498836
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76968811
49Renin-angiotensin system_Homo sapiens_hsa046140.76790514
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73181844
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.72291014
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72058285
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70573931
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70498992
55Propanoate metabolism_Homo sapiens_hsa006400.70101647
56Bile secretion_Homo sapiens_hsa049760.67498631
57Tyrosine metabolism_Homo sapiens_hsa003500.65805330
58Toxoplasmosis_Homo sapiens_hsa051450.65267159
59ABC transporters_Homo sapiens_hsa020100.64362256
60Vitamin B6 metabolism_Homo sapiens_hsa007500.63067772
61Retinol metabolism_Homo sapiens_hsa008300.61752026
62* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59440608
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57954207
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56974750
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56512731
66Pertussis_Homo sapiens_hsa051330.54432683
67Sphingolipid metabolism_Homo sapiens_hsa006000.52449179
68Selenocompound metabolism_Homo sapiens_hsa004500.52270849
69Arachidonic acid metabolism_Homo sapiens_hsa005900.51328160
70Phenylalanine metabolism_Homo sapiens_hsa003600.50091327
71Prion diseases_Homo sapiens_hsa050200.47974617
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.46734490
73Pyruvate metabolism_Homo sapiens_hsa006200.45659069
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44994803
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.43934979
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.42646332
77Starch and sucrose metabolism_Homo sapiens_hsa005000.41948555
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41213068
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40922488
80Metabolic pathways_Homo sapiens_hsa011000.40870949
81Thyroid hormone synthesis_Homo sapiens_hsa049180.40321012
82Mineral absorption_Homo sapiens_hsa049780.39194913
83Folate biosynthesis_Homo sapiens_hsa007900.38765548
84Renin secretion_Homo sapiens_hsa049240.37346235
85Fructose and mannose metabolism_Homo sapiens_hsa000510.36497959
86Fat digestion and absorption_Homo sapiens_hsa049750.35092721
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.34468046
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.34033636
89Arginine and proline metabolism_Homo sapiens_hsa003300.33859444
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.31077475
91Pentose phosphate pathway_Homo sapiens_hsa000300.30750838
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30511153
93Sulfur relay system_Homo sapiens_hsa041220.29853170
94Chemokine signaling pathway_Homo sapiens_hsa040620.29602634
95Serotonergic synapse_Homo sapiens_hsa047260.28713201
96Biosynthesis of amino acids_Homo sapiens_hsa012300.28021980
97Osteoclast differentiation_Homo sapiens_hsa043800.26369412
98Linoleic acid metabolism_Homo sapiens_hsa005910.26211885
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25731716
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25581138
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25168329
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.24408233
103Taste transduction_Homo sapiens_hsa047420.22816503
104B cell receptor signaling pathway_Homo sapiens_hsa046620.22091120
105GABAergic synapse_Homo sapiens_hsa047270.21909106
106Amoebiasis_Homo sapiens_hsa051460.21839731
107Vitamin digestion and absorption_Homo sapiens_hsa049770.21304034
108Circadian rhythm_Homo sapiens_hsa047100.20719563
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20405405
110Rheumatoid arthritis_Homo sapiens_hsa053230.19266192
111Glycerolipid metabolism_Homo sapiens_hsa005610.18017121
112TNF signaling pathway_Homo sapiens_hsa046680.16517718
113Pancreatic cancer_Homo sapiens_hsa052120.16190070
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16116702
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16020388
116FoxO signaling pathway_Homo sapiens_hsa040680.15384245
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14924743
118Glucagon signaling pathway_Homo sapiens_hsa049220.13891931
119Systemic lupus erythematosus_Homo sapiens_hsa053220.12893579
120Lysine degradation_Homo sapiens_hsa003100.12881789
121Carbon metabolism_Homo sapiens_hsa012000.12119958
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11907662
123Insulin resistance_Homo sapiens_hsa049310.11808138
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.11208012
125Protein export_Homo sapiens_hsa030600.10077002
126Hepatitis C_Homo sapiens_hsa051600.09798612
127Prolactin signaling pathway_Homo sapiens_hsa049170.09634872
128Fatty acid biosynthesis_Homo sapiens_hsa000610.09458421
129Tuberculosis_Homo sapiens_hsa051520.09455092
130Glutathione metabolism_Homo sapiens_hsa004800.08518160
131Morphine addiction_Homo sapiens_hsa050320.04144708

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