IL17RD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.77323243
2pre-miRNA processing (GO:0031054)5.37554328
3regulation of posttranscriptional gene silencing (GO:0060147)5.33711614
4regulation of gene silencing by miRNA (GO:0060964)5.33711614
5regulation of gene silencing by RNA (GO:0060966)5.33711614
6nuclear pore organization (GO:0006999)4.45871797
7presynaptic membrane assembly (GO:0097105)4.41658875
8nuclear pore complex assembly (GO:0051292)4.40120126
9pyrimidine nucleobase catabolic process (GO:0006208)4.13450087
10limb bud formation (GO:0060174)3.99412234
11notochord development (GO:0030903)3.93184310
12presynaptic membrane organization (GO:0097090)3.88565693
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.79924900
14axon extension involved in axon guidance (GO:0048846)3.79924900
15postsynaptic membrane organization (GO:0001941)3.79147522
16regulation of sister chromatid cohesion (GO:0007063)3.78301671
17anterior/posterior axis specification, embryo (GO:0008595)3.69621222
18somite development (GO:0061053)3.56071712
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.53223296
20polarized epithelial cell differentiation (GO:0030859)3.49641458
21DNA replication-dependent nucleosome organization (GO:0034723)3.46717876
22DNA replication-dependent nucleosome assembly (GO:0006335)3.46717876
23establishment of apical/basal cell polarity (GO:0035089)3.45669396
24heterochromatin organization (GO:0070828)3.45464734
25DNA unwinding involved in DNA replication (GO:0006268)3.43737773
26hippo signaling (GO:0035329)3.42956681
27protein localization to kinetochore (GO:0034501)3.41158081
28regulation of cell fate specification (GO:0042659)3.39278817
29mitotic metaphase plate congression (GO:0007080)3.38603818
30outer ear morphogenesis (GO:0042473)3.36955388
31nonmotile primary cilium assembly (GO:0035058)3.36655883
32dorsal/ventral axis specification (GO:0009950)3.34672618
33regulation of hippo signaling (GO:0035330)3.32620719
34neuronal stem cell maintenance (GO:0097150)3.31990356
35retinal ganglion cell axon guidance (GO:0031290)3.31639811
36calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.30171954
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.27877474
38positive regulation of SMAD protein import into nucleus (GO:0060391)3.26657145
39mitotic sister chromatid segregation (GO:0000070)3.25442605
40mitotic nuclear envelope disassembly (GO:0007077)3.23871212
41neuron cell-cell adhesion (GO:0007158)3.22606504
42pore complex assembly (GO:0046931)3.20205558
43histone H2A monoubiquitination (GO:0035518)3.17714837
44sister chromatid segregation (GO:0000819)3.17368941
45negative regulation of histone methylation (GO:0031061)3.16686747
46limb development (GO:0060173)3.13368018
47appendage development (GO:0048736)3.13368018
48nucleobase catabolic process (GO:0046113)3.12536751
49negative regulation of DNA repair (GO:0045738)3.09632119
50cell migration involved in gastrulation (GO:0042074)3.09304943
51axonal fasciculation (GO:0007413)3.08730199
52spinal cord development (GO:0021510)3.08415386
53establishment of tissue polarity (GO:0007164)3.06058010
54establishment of planar polarity (GO:0001736)3.06058010
55regulation of non-canonical Wnt signaling pathway (GO:2000050)3.05070021
56nuclear envelope disassembly (GO:0051081)3.03003300
57membrane disassembly (GO:0030397)3.03003300
58metaphase plate congression (GO:0051310)3.02807043
59neuron recognition (GO:0008038)3.02017161
60regulation of histone H3-K9 methylation (GO:0051570)3.00907969
61kidney morphogenesis (GO:0060993)2.99853273
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.99459137
63establishment of monopolar cell polarity (GO:0061162)2.99436566
64establishment or maintenance of monopolar cell polarity (GO:0061339)2.99436566
65regulation of telomere maintenance via telomerase (GO:0032210)2.99012216
66tongue development (GO:0043586)2.97903125
67lateral sprouting from an epithelium (GO:0060601)2.97493504
68regulation of helicase activity (GO:0051095)2.96846141
69regulation of SMAD protein import into nucleus (GO:0060390)2.96765137
70mitotic chromosome condensation (GO:0007076)2.93585755
71mitotic sister chromatid cohesion (GO:0007064)2.93365986
72negative regulation of axon guidance (GO:1902668)2.92313637
73regulation of gene silencing (GO:0060968)2.92297519
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91075319
75cell proliferation in forebrain (GO:0021846)2.89704258
76regulation of mitotic spindle organization (GO:0060236)2.88785003
77regulation of spindle organization (GO:0090224)2.88149452
78regulation of mesoderm development (GO:2000380)2.87457621
79cell migration in hindbrain (GO:0021535)2.86204674
80positive regulation of mitotic sister chromatid separation (GO:1901970)2.86040270
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86040270
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86040270
83regulation of cell fate commitment (GO:0010453)2.85079876
84positive regulation of chromosome segregation (GO:0051984)2.84405313
85regulation of RNA export from nucleus (GO:0046831)2.83211908
86generation of neurons (GO:0048699)2.82478302
87intraciliary transport (GO:0042073)2.82027820
88positive regulation of gastrulation (GO:2000543)2.80882768
89regulation of chromosome segregation (GO:0051983)2.80871276
90negative regulation of chromosome segregation (GO:0051985)2.80078876
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79565024
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.79565024
93regulation of translation, ncRNA-mediated (GO:0045974)2.79565024
94olfactory bulb development (GO:0021772)2.79026390
95DNA geometric change (GO:0032392)2.78607549
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78273413
97DNA duplex unwinding (GO:0032508)2.77816756
98chromatin assembly (GO:0031497)2.76893018
99regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.75950466
100ephrin receptor signaling pathway (GO:0048013)2.74246905
101protein localization to chromosome, centromeric region (GO:0071459)2.74171014
102kinetochore organization (GO:0051383)2.72936767
103lung-associated mesenchyme development (GO:0060484)2.71371836
104regulation of centriole replication (GO:0046599)2.70453309
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69006346
106negative regulation of sister chromatid segregation (GO:0033046)2.69006346
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.69006346
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69006346
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68242402
110spindle assembly checkpoint (GO:0071173)2.67390189
111mitotic spindle checkpoint (GO:0071174)2.67072961
112ncRNA catabolic process (GO:0034661)2.66894502
113spindle checkpoint (GO:0031577)2.66090677
114mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.66056918
115mitotic spindle assembly checkpoint (GO:0007094)2.66008067
116regulation of gastrulation (GO:0010470)2.65752723
117protein K6-linked ubiquitination (GO:0085020)2.65282714
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65097084
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64595610
120vocalization behavior (GO:0071625)2.64455190
121regulation of axon guidance (GO:1902667)2.64207247
122axon extension (GO:0048675)2.62467752
123attachment of spindle microtubules to kinetochore (GO:0008608)2.60886432
124hindlimb morphogenesis (GO:0035137)2.59773630
125regulation of mitotic sister chromatid separation (GO:0010965)2.59750314
126regulation of mitotic sister chromatid segregation (GO:0033047)2.59750314
127regulation of sister chromatid segregation (GO:0033045)2.59750314
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59130210
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.59130210
130negative chemotaxis (GO:0050919)2.58537205
131cochlea morphogenesis (GO:0090103)2.57580675
132negative regulation of cell fate specification (GO:0009996)2.57443858
133regulation of centrosome cycle (GO:0046605)2.57007189
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.56636288
135convergent extension (GO:0060026)2.55449105
136peptidyl-arginine omega-N-methylation (GO:0035247)2.55045763
137regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.54751355
138kinetochore assembly (GO:0051382)2.54256376
139regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.54072831
140DNA replication initiation (GO:0006270)2.53802011
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53737664
142cell surface receptor signaling pathway involved in heart development (GO:0061311)2.51083910
143embryonic hindlimb morphogenesis (GO:0035116)2.50941310
144anterior/posterior axis specification (GO:0009948)2.50755855
145apical protein localization (GO:0045176)2.50508928
146regulation of stem cell maintenance (GO:2000036)2.50206615
147proximal/distal pattern formation (GO:0009954)2.49896794
148dosage compensation (GO:0007549)2.49871903
149organ induction (GO:0001759)2.47638078
150regulation of establishment of planar polarity (GO:0090175)2.47568527
151developmental induction (GO:0031128)2.46723285
152negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.45531872
153cell-cell signaling involved in cell fate commitment (GO:0045168)2.44341634
154body morphogenesis (GO:0010171)2.44225035
155cerebral cortex radially oriented cell migration (GO:0021799)2.43739064
156embryonic body morphogenesis (GO:0010172)2.42317664
157establishment of mitochondrion localization (GO:0051654)2.38913979
158transmission of nerve impulse (GO:0019226)2.37436555
159smoothened signaling pathway (GO:0007224)2.36968753
160lens fiber cell development (GO:0070307)2.36521034
161behavioral response to nicotine (GO:0035095)2.35613966
162pituitary gland development (GO:0021983)2.34165024
163camera-type eye morphogenesis (GO:0048593)2.34023767
164post-anal tail morphogenesis (GO:0036342)2.33415574
165chromatin remodeling at centromere (GO:0031055)2.33337671
166non-canonical Wnt signaling pathway (GO:0035567)2.33241701
167head development (GO:0060322)2.33055061
168epithelial cilium movement (GO:0003351)2.31723457
169positive regulation of neuroblast proliferation (GO:0002052)2.31351687
170central nervous system projection neuron axonogenesis (GO:0021952)2.29905675
171short-term memory (GO:0007614)2.29683830
172thalamus development (GO:0021794)2.29589552
173neuron fate determination (GO:0048664)2.29551221
174regulation of development, heterochronic (GO:0040034)2.29523129
175mesenchymal to epithelial transition (GO:0060231)2.27238421
176radial glial cell differentiation (GO:0060019)2.25848152
177dorsal/ventral pattern formation (GO:0009953)2.25643312
178neural tube closure (GO:0001843)2.24079084
179tube closure (GO:0060606)2.21821052
180protein localization to synapse (GO:0035418)2.20769076
181hindbrain development (GO:0030902)2.20628455
182artery development (GO:0060840)2.20097136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36779229
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.06681130
3EZH2_22144423_ChIP-Seq_EOC_Human5.02055607
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.81031221
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.81031221
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.81031221
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49763872
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.49527606
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08457291
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.04486430
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.01971350
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84938476
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.84865378
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.74364150
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.69799555
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.63050467
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57466694
18* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.50052781
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47105894
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.45192601
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.43059191
22AR_21909140_ChIP-Seq_LNCAP_Human2.36753246
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34652032
24* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.32277543
25* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.30544379
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.26883279
27GBX2_23144817_ChIP-Seq_PC3_Human2.26708009
28* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.25589683
29* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.22939639
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21120724
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.11270854
32FUS_26573619_Chip-Seq_HEK293_Human2.09308615
33* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.08205658
34TAF15_26573619_Chip-Seq_HEK293_Human2.03663345
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02591748
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98454480
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94036971
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93060617
39ZNF274_21170338_ChIP-Seq_K562_Hela1.92943249
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91848742
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.90126516
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88726517
43IGF1R_20145208_ChIP-Seq_DFB_Human1.87578032
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.84705383
45* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84284326
46* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83537616
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.79342114
48* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.77693765
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76460806
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73124097
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72168962
52* P300_19829295_ChIP-Seq_ESCs_Human1.70502937
53RNF2_27304074_Chip-Seq_NSC_Mouse1.70100076
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68719687
55* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67339562
56EWS_26573619_Chip-Seq_HEK293_Human1.65151417
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64663075
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61994004
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59985604
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59128549
61* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58833365
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58499206
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.57993906
64* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.56549345
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55179856
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54808356
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54086635
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53538853
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.52297070
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.52128917
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50579502
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50579502
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48905933
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.48578420
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48468347
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48468347
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.45552715
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.42847896
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42043431
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41873851
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41784444
82* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.41419359
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40324633
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39387910
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37570105
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37520850
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37349920
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37114611
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.35784478
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35738632
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.34474852
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34384548
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.31977706
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31494932
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31456235
96IRF1_19129219_ChIP-ChIP_H3396_Human1.30815241
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30153601
98XRN2_22483619_ChIP-Seq_HELA_Human1.29694172
99* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28347216
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28314633
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27628500
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27573592
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.27545148
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27444691
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26809683
106* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26551460
107VDR_22108803_ChIP-Seq_LS180_Human1.26215047
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23486373
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23034842
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22984092
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22426683
112SMAD4_21799915_ChIP-Seq_A2780_Human1.21669722
113* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19795993
114PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.19685327
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18323733
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.17605149
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17595743
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17329464
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16895422
120TTF2_22483619_ChIP-Seq_HELA_Human1.16540868
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15062635
122* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14746548
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13812982
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13635837
125* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12723156
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12695143
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12468972
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12464348
129TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11836383
130* REST_21632747_ChIP-Seq_MESCs_Mouse1.11802808
131SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11626194
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11194556
133* SOX9_26525672_Chip-Seq_HEART_Mouse1.09920736
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09617077
135RUNX2_22187159_ChIP-Seq_PCA_Human1.09259033
136NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08929785
137* STAT3_23295773_ChIP-Seq_U87_Human1.05671596
138* ISL1_27105846_Chip-Seq_CPCs_Mouse1.05580744
139SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04701833
140ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04270551
141* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03909075
142* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03890044
143* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03483053
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03461240
145* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03214196
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03109371
147KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02237363
148EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01611687
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01110029
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00838198
151YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00541304
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99995462
153ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99979406
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99325392
155* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98227194
156* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96135526
157MYC_22102868_ChIP-Seq_BL_Human0.93719081
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93308538
159* NANOG_16518401_ChIP-PET_MESCs_Mouse0.91624707
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91608776
161OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88858536
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87885787
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86760413
164PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86618249
165WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85636217
166CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84550132
167* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84080607
168MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83635101
169CHD1_26751641_Chip-Seq_LNCaP_Human0.83389558
170WT1_19549856_ChIP-ChIP_CCG9911_Human0.82136786
171KDM5A_27292631_Chip-Seq_BREAST_Human0.81139375
172PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79407188
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78928791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.10830553
2MP0003123_paternal_imprinting2.69237086
3MP0009053_abnormal_anal_canal2.66012754
4MP0003941_abnormal_skin_development2.65069837
5MP0003111_abnormal_nucleus_morphology2.54319309
6MP0000778_abnormal_nervous_system2.52436317
7MP0003890_abnormal_embryonic-extraembry2.45094837
8MP0000537_abnormal_urethra_morphology2.43786005
9MP0010094_abnormal_chromosome_stability2.34055156
10MP0004957_abnormal_blastocyst_morpholog2.27886545
11MP0003121_genomic_imprinting2.23923324
12MP0002653_abnormal_ependyma_morphology2.17387774
13MP0003937_abnormal_limbs/digits/tail_de2.15572752
14MP0003077_abnormal_cell_cycle2.11372099
15MP0003119_abnormal_digestive_system2.04428939
16MP0003705_abnormal_hypodermis_morpholog2.00746179
17MP0003693_abnormal_embryo_hatching1.99338355
18MP0003136_yellow_coat_color1.99021546
19MP0002084_abnormal_developmental_patter1.95308271
20MP0008057_abnormal_DNA_replication1.92467348
21MP0001293_anophthalmia1.90446597
22MP0010352_gastrointestinal_tract_polyps1.90415935
23MP0002085_abnormal_embryonic_tissue1.90057036
24MP0002249_abnormal_larynx_morphology1.81875220
25MP0001672_abnormal_embryogenesis/_devel1.80151163
26MP0005380_embryogenesis_phenotype1.80151163
27MP0001299_abnormal_eye_distance/1.79477255
28MP0008932_abnormal_embryonic_tissue1.75366480
29MP0000049_abnormal_middle_ear1.73028228
30MP0003385_abnormal_body_wall1.72453921
31MP0003880_abnormal_central_pattern1.69769672
32MP0008877_abnormal_DNA_methylation1.68604801
33MP0001730_embryonic_growth_arrest1.67602791
34MP0004133_heterotaxia1.67378110
35MP0003122_maternal_imprinting1.64681527
36MP0004197_abnormal_fetal_growth/weight/1.64601757
37MP0005076_abnormal_cell_differentiation1.63320489
38MP0003942_abnormal_urinary_system1.61118803
39MP0000428_abnormal_craniofacial_morphol1.60597931
40MP0005623_abnormal_meninges_morphology1.58864697
41MP0003984_embryonic_growth_retardation1.56404077
42MP0002088_abnormal_embryonic_growth/wei1.54555722
43MP0006072_abnormal_retinal_apoptosis1.54482306
44MP0003935_abnormal_craniofacial_develop1.54090125
45MP0000350_abnormal_cell_proliferation1.54082144
46MP0004272_abnormal_basement_membrane1.53952167
47MP0001697_abnormal_embryo_size1.52791025
48MP0001984_abnormal_olfaction1.51488812
49MP0003755_abnormal_palate_morphology1.50340244
50MP0000432_abnormal_head_morphology1.47184015
51MP0002111_abnormal_tail_morphology1.46988993
52MP0002932_abnormal_joint_morphology1.46921043
53MP0008007_abnormal_cellular_replicative1.45227940
54MP0002086_abnormal_extraembryonic_tissu1.45223442
55MP0000579_abnormal_nail_morphology1.45222459
56MP0003567_abnormal_fetal_cardiomyocyte1.44553262
57MP0002233_abnormal_nose_morphology1.43297258
58MP0000631_abnormal_neuroendocrine_gland1.41179277
59MP0005367_renal/urinary_system_phenotyp1.38304565
60MP0000516_abnormal_urinary_system1.38304565
61MP0002938_white_spotting1.37347504
62MP0003787_abnormal_imprinting1.37117363
63MP0006292_abnormal_olfactory_placode1.36530770
64MP0008058_abnormal_DNA_repair1.36075233
65MP0003283_abnormal_digestive_organ1.35641186
66MP0000534_abnormal_ureter_morphology1.34649578
67MP0002697_abnormal_eye_size1.34340264
68MP0009250_abnormal_appendicular_skeleto1.31401389
69MP0004859_abnormal_synaptic_plasticity1.29669283
70MP0001529_abnormal_vocalization1.28721457
71MP0000955_abnormal_spinal_cord1.28274524
72MP0002184_abnormal_innervation1.27282219
73MP0002116_abnormal_craniofacial_bone1.25831694
74MP0003315_abnormal_perineum_morphology1.24203977
75MP0003878_abnormal_ear_physiology1.24115084
76MP0005377_hearing/vestibular/ear_phenot1.24115084
77MP0009703_decreased_birth_body1.23157525
78MP0000733_abnormal_muscle_development1.22985308
79MP0002751_abnormal_autonomic_nervous1.22895609
80MP0001286_abnormal_eye_development1.22772810
81MP0001849_ear_inflammation1.22252983
82MP0000566_synostosis1.22028393
83MP0004885_abnormal_endolymph1.21161752
84MP0003115_abnormal_respiratory_system1.20747701
85MP0005503_abnormal_tendon_morphology1.18375080
86MP0003861_abnormal_nervous_system1.16585984
87MP0002102_abnormal_ear_morphology1.16110065
88MP0010307_abnormal_tumor_latency1.14875035
89MP0005187_abnormal_penis_morphology1.14507144
90MP0002092_abnormal_eye_morphology1.14153859
91MP0002080_prenatal_lethality1.13693571
92MP0004233_abnormal_muscle_weight1.12913176
93MP0008789_abnormal_olfactory_epithelium1.12543310
94* MP0002152_abnormal_brain_morphology1.12140420
95MP0009672_abnormal_birth_weight1.11646621
96MP0006276_abnormal_autonomic_nervous1.11627772
97MP0005391_vision/eye_phenotype1.10626273
98MP0000026_abnormal_inner_ear1.10166766
99MP0000762_abnormal_tongue_morphology1.09018620
100MP0002638_abnormal_pupillary_reflex1.08284955
101MP0002752_abnormal_somatic_nervous1.08241519
102MP0002282_abnormal_trachea_morphology1.08068810
103MP0008438_abnormal_cutaneous_collagen1.07482446
104MP0002925_abnormal_cardiovascular_devel1.07476933
105MP0005248_abnormal_Harderian_gland1.07406984
106MP0001485_abnormal_pinna_reflex1.07041995
107MP0002736_abnormal_nociception_after1.05852770
108MP0005508_abnormal_skeleton_morphology1.05834451
109MP0002114_abnormal_axial_skeleton1.05526716
110MP0004270_analgesia1.02353721
111MP0005253_abnormal_eye_physiology1.01785509
112MP0000647_abnormal_sebaceous_gland0.98850929
113MP0000678_abnormal_parathyroid_gland0.98623365
114MP0002557_abnormal_social/conspecific_i0.97866075
115MP0002109_abnormal_limb_morphology0.97604234
116MP0004264_abnormal_extraembryonic_tissu0.97198133
117MP0000383_abnormal_hair_follicle0.96268938
118MP0005423_abnormal_somatic_nervous0.96042043
119MP0003938_abnormal_ear_development0.95921471
120MP0001346_abnormal_lacrimal_gland0.95813884
121MP0005257_abnormal_intraocular_pressure0.95328603
122MP0003566_abnormal_cell_adhesion0.95317563
123MP0001915_intracranial_hemorrhage0.92749057
124MP0002734_abnormal_mechanical_nocicepti0.92213693
125MP0005394_taste/olfaction_phenotype0.91149719
126MP0005499_abnormal_olfactory_system0.91149719
127MP0002210_abnormal_sex_determination0.90648271
128MP0001486_abnormal_startle_reflex0.90534800
129MP0002882_abnormal_neuron_morphology0.89932230
130MP0002081_perinatal_lethality0.88876506
131MP0002177_abnormal_outer_ear0.87965661
132MP0005195_abnormal_posterior_eye0.87299191
133MP0005171_absent_coat_pigmentation0.87295955
134MP0001177_atelectasis0.86191363
135MP0003786_premature_aging0.84952803
136MP0002822_catalepsy0.82917046
137MP0003635_abnormal_synaptic_transmissio0.81767953
138MP0002234_abnormal_pharynx_morphology0.81666228
139MP0002735_abnormal_chemical_nociception0.81208231
140MP0000569_abnormal_digit_pigmentation0.80962541
141MP0001188_hyperpigmentation0.80172343
142MP0002127_abnormal_cardiovascular_syste0.79858504
143MP0001145_abnormal_male_reproductive0.79188333
144MP0002063_abnormal_learning/memory/cond0.77383969
145MP0001324_abnormal_eye_pigmentation0.74809580

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)3.53303832
2Septo-optic dysplasia (HP:0100842)3.52589227
3Short 4th metacarpal (HP:0010044)3.37497349
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.37497349
5Renal duplication (HP:0000075)2.99801640
6Abnormality of the 4th metacarpal (HP:0010012)2.83219244
7Shallow orbits (HP:0000586)2.75427253
8Ependymoma (HP:0002888)2.74129038
9True hermaphroditism (HP:0010459)2.73815091
10Vitreoretinal degeneration (HP:0000655)2.73502540
11Selective tooth agenesis (HP:0001592)2.69931102
12Shawl scrotum (HP:0000049)2.65013248
13Medulloblastoma (HP:0002885)2.62554787
14Abnormality of the labia minora (HP:0012880)2.57844032
15Rib fusion (HP:0000902)2.52950038
16Cortical dysplasia (HP:0002539)2.51110574
17Broad thumb (HP:0011304)2.46931870
18Nephronophthisis (HP:0000090)2.44258504
19Absent radius (HP:0003974)2.40890937
20Vaginal atresia (HP:0000148)2.40637389
21Colon cancer (HP:0003003)2.37720010
22Short humerus (HP:0005792)2.37377954
23Pancreatic fibrosis (HP:0100732)2.35987647
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35040456
25Genital tract atresia (HP:0001827)2.34239571
26Chromsome breakage (HP:0040012)2.33492199
27Optic nerve hypoplasia (HP:0000609)2.33431936
28Aplasia/hypoplasia of the humerus (HP:0006507)2.32444086
29Astrocytoma (HP:0009592)2.31989773
30Abnormality of the astrocytes (HP:0100707)2.31989773
31Supernumerary ribs (HP:0005815)2.28525928
32Gait imbalance (HP:0002141)2.28463486
33Oligodactyly (HP:0012165)2.27686652
34Aplasia involving forearm bones (HP:0009822)2.27648539
35Absent forearm bone (HP:0003953)2.27648539
36Skull defect (HP:0001362)2.24588151
37Midline defect of the nose (HP:0004122)2.24517250
38Increased nuchal translucency (HP:0010880)2.24393191
39Supernumerary spleens (HP:0009799)2.23244365
40Neoplasm of the oral cavity (HP:0100649)2.22724944
41Bifid tongue (HP:0010297)2.20193658
42Deviation of the thumb (HP:0009603)2.20090276
43Trigonocephaly (HP:0000243)2.17964631
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.16308276
45Abnormality of abdominal situs (HP:0011620)2.15215401
46Abdominal situs inversus (HP:0003363)2.15215401
47Supernumerary bones of the axial skeleton (HP:0009144)2.14226841
48Abnormal number of incisors (HP:0011064)2.13968911
49Glioma (HP:0009733)2.13528794
50Ectopic kidney (HP:0000086)2.13448220
51Anencephaly (HP:0002323)2.13303917
52Congenital primary aphakia (HP:0007707)2.13153300
53Medial flaring of the eyebrow (HP:0010747)2.11824709
54Rhabdomyosarcoma (HP:0002859)2.10924723
55Abnormality of the distal phalanx of the thumb (HP:0009617)2.10107284
56Pancreatic cysts (HP:0001737)2.09535428
57Proximal placement of thumb (HP:0009623)2.09058911
58Facial hemangioma (HP:0000329)2.08778094
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08404442
60Abnormal lung lobation (HP:0002101)2.08023434
61Short middle phalanx of the 5th finger (HP:0004220)2.07385785
62Postaxial hand polydactyly (HP:0001162)2.06573294
63Broad phalanges of the hand (HP:0009768)2.05309930
64Maternal diabetes (HP:0009800)2.04608813
65Neoplasm of striated muscle (HP:0009728)2.03925476
66Short 1st metacarpal (HP:0010034)2.03899076
67Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03899076
68Postaxial foot polydactyly (HP:0001830)2.03612873
69Esophageal atresia (HP:0002032)2.03478410
70Broad foot (HP:0001769)2.02456819
71Neonatal short-limb short stature (HP:0008921)2.01034495
72Atresia of the external auditory canal (HP:0000413)2.00845173
73Short 5th finger (HP:0009237)2.00511848
74Short phalanx of the thumb (HP:0009660)1.99673309
75Molar tooth sign on MRI (HP:0002419)1.98779062
76Abnormality of midbrain morphology (HP:0002418)1.98779062
77Patellar aplasia (HP:0006443)1.98102826
78Morphological abnormality of the middle ear (HP:0008609)1.97991881
79Bilateral microphthalmos (HP:0007633)1.97969207
80Absent septum pellucidum (HP:0001331)1.97786264
81Fibular hypoplasia (HP:0003038)1.97445288
82Renal hypoplasia (HP:0000089)1.97300014
83Mesomelia (HP:0003027)1.96070564
84Synostosis of carpal bones (HP:0005048)1.96012691
85Hypoplastic labia majora (HP:0000059)1.95464174
86Micropenis (HP:0000054)1.95348177
87Oligodactyly (hands) (HP:0001180)1.94837971
88Broad finger (HP:0001500)1.94626705
89Nephrogenic diabetes insipidus (HP:0009806)1.93658802
90Missing ribs (HP:0000921)1.92307192
91Abnormality of the diencephalon (HP:0010662)1.92267326
92Long eyelashes (HP:0000527)1.91774254
93Malignant gastrointestinal tract tumors (HP:0006749)1.91607153
94Gastrointestinal carcinoma (HP:0002672)1.91607153
95Abnormality of the renal medulla (HP:0100957)1.91506409
96High anterior hairline (HP:0009890)1.91232258
97Aplasia/Hypoplasia of the patella (HP:0006498)1.91080290
98Abnormality of the ischium (HP:0003174)1.90674392
99Nephroblastoma (Wilms tumor) (HP:0002667)1.89832502
100Choanal stenosis (HP:0000452)1.89255680
101Preaxial hand polydactyly (HP:0001177)1.88841368
102Coronal craniosynostosis (HP:0004440)1.88834494
103Meckel diverticulum (HP:0002245)1.88721145
104Ankle contracture (HP:0006466)1.87504140
105Broad toe (HP:0001837)1.87389188
106Abnormality of the phalanges of the hallux (HP:0010057)1.86833393
107Breast hypoplasia (HP:0003187)1.86646428
108Anal stenosis (HP:0002025)1.85855300
109Poor coordination (HP:0002370)1.85805379
110Omphalocele (HP:0001539)1.85398939
111Hemivertebrae (HP:0002937)1.84897369
112Abnormality of the parietal bone (HP:0002696)1.84832581
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.83781604
114Preaxial foot polydactyly (HP:0001841)1.83622099
115Carpal synostosis (HP:0009702)1.83021670
116Broad phalanx (HP:0006009)1.82398068
117Abnormality of the ileum (HP:0001549)1.81322716
118Abnormality of the septum pellucidum (HP:0007375)1.81207813
119Cutaneous finger syndactyly (HP:0010554)1.80938620
120Impulsivity (HP:0100710)1.80753038
121Protrusio acetabuli (HP:0003179)1.79681656
122Sclerocornea (HP:0000647)1.79431415
123Rectovaginal fistula (HP:0000143)1.79290945
124Rectal fistula (HP:0100590)1.79290945
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.78724874
126Fused cervical vertebrae (HP:0002949)1.78512263
127Drooling (HP:0002307)1.77991097
128Broad long bones (HP:0005622)1.77927348
129Embryonal renal neoplasm (HP:0011794)1.77766830
130Anophthalmia (HP:0000528)1.77738182
131Vertebral fusion (HP:0002948)1.77658858
132Facial cleft (HP:0002006)1.77375488
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.76606555
134Absent eyebrow (HP:0002223)1.76040770
135Intestinal atresia (HP:0011100)1.75714311
136Myelomeningocele (HP:0002475)1.74819454
137Abnormality of the labia majora (HP:0012881)1.74775202
138Urethral obstruction (HP:0000796)1.74733706
139Occipital encephalocele (HP:0002085)1.74669821
140Turricephaly (HP:0000262)1.74558473
141Bicornuate uterus (HP:0000813)1.74425791
142Abnormality of the nasal septum (HP:0000419)1.74218027
143Hypoplastic pelvis (HP:0008839)1.74215581
144Hypoplastic ischia (HP:0003175)1.74076309
145Intestinal fistula (HP:0100819)1.73785731
146Pseudobulbar signs (HP:0002200)1.73404513
147Renovascular hypertension (HP:0100817)1.72994535
148Chronic hepatic failure (HP:0100626)1.72990042
149Holoprosencephaly (HP:0001360)1.72697700
150Calcaneovalgus deformity (HP:0001848)1.72165521
151Narrow forehead (HP:0000341)1.72148950
152Cutaneous syndactyly (HP:0012725)1.71280378
153Biliary tract neoplasm (HP:0100574)1.70917123
154Abnormality of the pubic bones (HP:0003172)1.70582655
155Abnormality of the aortic arch (HP:0012303)1.70418395
156Aqueductal stenosis (HP:0002410)1.69813085
157Labial hypoplasia (HP:0000066)1.67673634
158Hyperglycinemia (HP:0002154)1.65342595
159Partial agenesis of the corpus callosum (HP:0001338)1.63456531
160Dandy-Walker malformation (HP:0001305)1.63413964
161Deformed tarsal bones (HP:0008119)1.63276358
162Cystic liver disease (HP:0006706)1.61020480
163* Aplasia/Hypoplasia of the breasts (HP:0010311)1.60273181
164Aplasia/Hypoplasia of the fibula (HP:0006492)1.60029841
165Renal dysplasia (HP:0000110)1.60025863
166Specific learning disability (HP:0001328)1.59578902
167Scrotal hypoplasia (HP:0000046)1.58514338
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.57567632
169Bronchomalacia (HP:0002780)1.55836740
170Irregular epiphyses (HP:0010582)1.55068369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.48679838
2LATS13.81394363
3TNIK3.77544890
4CDC73.74074467
5CASK3.07292743
6LATS22.96174106
7MARK12.71454676
8TTK2.67288677
9NEK22.52412631
10STK38L2.50156235
11EPHA22.48444940
12WNK32.35953031
13CDK192.17022607
14NEK12.08113328
15MKNK12.07626200
16MAP3K42.06975806
17BUB11.97576580
18EPHA41.95172287
19MKNK21.91564887
20WEE11.80684445
21SRPK11.76081895
22BRD41.75131868
23CDK71.74844664
24PDGFRA1.74215774
25TRIM281.71486570
26NTRK11.71088936
27STK31.68655042
28DDR21.66820968
29EEF2K1.66584999
30RPS6KB21.61690568
31PLK11.61354683
32NTRK21.59338249
33EPHB21.56537820
34AKT31.55023903
35MAP4K21.54770182
36PINK11.54400382
37CHEK21.53639949
38TSSK61.49595717
39PLK41.49054272
40TTN1.44038303
41MAP2K71.42500888
42PLK31.42481552
43PASK1.42382567
44ICK1.39818325
45PAK41.38800810
46ATR1.38654364
47CSNK1G21.38269674
48MAP3K101.33833462
49MTOR1.32706818
50CHEK11.31929986
51AURKB1.23585383
52CDK41.19863583
53TAF11.18993322
54MAPK151.17197655
55NUAK11.16119407
56CDK61.14410843
57BMPR1B1.12831233
58FGFR11.10451199
59ATM1.07410712
60MAP3K81.05140471
61TGFBR11.01777878
62ZAK1.01756652
63ACVR1B0.99344593
64CSNK1G30.98346016
65DYRK1B0.97566035
66TYRO30.96745253
67CDK20.95058857
68DYRK1A0.92366241
69RIPK10.88777457
70ALK0.87256958
71MAPK130.86439506
72STK100.86424687
73PNCK0.84458026
74MELK0.84400971
75DYRK30.83539452
76PRKCG0.83360477
77CAMK1D0.81622336
78AURKA0.78759195
79CDK10.77367836
80MET0.76836768
81AKT20.76306675
82STK40.76057371
83ERBB40.75432299
84PTK60.75372154
85BMX0.74233638
86CSNK1E0.68982042
87CSNK1D0.68314917
88PRKD30.67089226
89CDK90.67021847
90PAK20.67004893
91PDGFRB0.66391884
92ERBB30.64872709
93PKN20.61273927
94CDK180.59150559
95ROCK20.58948205
96PTK20.58692040
97CDK11A0.57648553
98VRK10.57029800
99FER0.56901692
100PRKCE0.56177144
101TLK10.55817044
102TIE10.55624051
103CDK150.54892349
104PRKCI0.54296056
105PRKDC0.53163459
106MINK10.52415881
107UHMK10.51004825
108CSNK1A1L0.50681778
109STK380.50435320
110AKT10.50354145
111CAMK1G0.49948763
112CDK50.49840394
113MAP3K90.49814830
114SGK4940.49656705
115SGK2230.49656705
116WNK40.47865438
117MAPK140.47575172
118CDK140.47502821
119CDK80.47479305
120SIK10.45731341
121BRSK20.43747971
122NLK0.43717931
123GSK3B0.43532402
124MAPK10.43410582
125CSNK1G10.42577904
126BCR0.42467586
127OXSR10.42276046
128RPS6KA40.41647035
129FGFR20.40962493
130YES10.40750334
131STK390.40674798
132PAK30.39824079
133STK110.39700666
134PAK60.39585491
135CSNK2A20.38843783
136PRKCZ0.38841025
137CAMK2A0.38501376
138KSR10.37894990
139CDK30.37513744
140CAMK10.37495369
141ERBB20.37259675
142SIK20.36686014
143PIM10.32641556
144PAK10.32095178
145MAPK100.31471871
146FLT30.29898703
147DYRK20.27792313
148CSNK2A10.27636443
149PLK20.27431766

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.25920012
2Mismatch repair_Homo sapiens_hsa034303.19825307
3RNA transport_Homo sapiens_hsa030133.04242539
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95972308
5Cell cycle_Homo sapiens_hsa041102.94316902
6DNA replication_Homo sapiens_hsa030302.87994963
7Spliceosome_Homo sapiens_hsa030402.77491542
8Hippo signaling pathway_Homo sapiens_hsa043902.66538895
9Hedgehog signaling pathway_Homo sapiens_hsa043402.45586851
10mRNA surveillance pathway_Homo sapiens_hsa030152.43516085
11Adherens junction_Homo sapiens_hsa045202.33104267
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.32895374
13Fanconi anemia pathway_Homo sapiens_hsa034602.22553506
14One carbon pool by folate_Homo sapiens_hsa006702.17475321
15Homologous recombination_Homo sapiens_hsa034402.16302672
16TGF-beta signaling pathway_Homo sapiens_hsa043502.09538352
17Nucleotide excision repair_Homo sapiens_hsa034202.02919669
18Base excision repair_Homo sapiens_hsa034101.95291758
19Steroid biosynthesis_Homo sapiens_hsa001001.94062275
20MicroRNAs in cancer_Homo sapiens_hsa052061.93132426
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91756156
22Nicotine addiction_Homo sapiens_hsa050331.90477083
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.86804462
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84481043
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79344559
26Basal transcription factors_Homo sapiens_hsa030221.79171269
27p53 signaling pathway_Homo sapiens_hsa041151.76271693
28RNA degradation_Homo sapiens_hsa030181.72108039
29Notch signaling pathway_Homo sapiens_hsa043301.69760140
30Wnt signaling pathway_Homo sapiens_hsa043101.67751536
31Protein export_Homo sapiens_hsa030601.66905416
32Propanoate metabolism_Homo sapiens_hsa006401.56315529
33RNA polymerase_Homo sapiens_hsa030201.48661767
34Tight junction_Homo sapiens_hsa045301.46380076
35Oocyte meiosis_Homo sapiens_hsa041141.41157663
36Phototransduction_Homo sapiens_hsa047441.40400650
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37030329
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35585396
39Proteoglycans in cancer_Homo sapiens_hsa052051.31448168
40Small cell lung cancer_Homo sapiens_hsa052221.28338649
41HTLV-I infection_Homo sapiens_hsa051661.23926266
42Thyroid cancer_Homo sapiens_hsa052161.21845154
43Colorectal cancer_Homo sapiens_hsa052101.21104737
44ECM-receptor interaction_Homo sapiens_hsa045121.19568814
45Systemic lupus erythematosus_Homo sapiens_hsa053221.19422574
46Non-homologous end-joining_Homo sapiens_hsa034501.18461469
47Pathways in cancer_Homo sapiens_hsa052001.17919491
48Lysine degradation_Homo sapiens_hsa003101.15870843
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15069338
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13653221
51Glutamatergic synapse_Homo sapiens_hsa047241.12113686
52Melanoma_Homo sapiens_hsa052181.11591758
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09564213
54Viral carcinogenesis_Homo sapiens_hsa052031.06760276
55Circadian entrainment_Homo sapiens_hsa047131.06655600
56Bladder cancer_Homo sapiens_hsa052191.05194967
57Focal adhesion_Homo sapiens_hsa045101.03713742
58Prostate cancer_Homo sapiens_hsa052151.01512254
59Melanogenesis_Homo sapiens_hsa049161.00710593
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99298788
61Endometrial cancer_Homo sapiens_hsa052130.96398829
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95669309
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94427249
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94213971
65mTOR signaling pathway_Homo sapiens_hsa041500.92806522
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92361082
67GABAergic synapse_Homo sapiens_hsa047270.91897271
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89480499
69Taste transduction_Homo sapiens_hsa047420.88620030
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86025401
71Morphine addiction_Homo sapiens_hsa050320.85627159
72Nitrogen metabolism_Homo sapiens_hsa009100.84619784
73Butanoate metabolism_Homo sapiens_hsa006500.83329313
74Pyrimidine metabolism_Homo sapiens_hsa002400.82945137
75Chronic myeloid leukemia_Homo sapiens_hsa052200.82276393
76Dopaminergic synapse_Homo sapiens_hsa047280.82081828
77Cocaine addiction_Homo sapiens_hsa050300.81280769
78Cardiac muscle contraction_Homo sapiens_hsa042600.80401068
79Viral myocarditis_Homo sapiens_hsa054160.80244602
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79274294
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.76639915
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74867651
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74537157
84Axon guidance_Homo sapiens_hsa043600.72565112
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72164691
86Rap1 signaling pathway_Homo sapiens_hsa040150.69971739
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67779215
88Insulin secretion_Homo sapiens_hsa049110.67481892
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67154114
90Olfactory transduction_Homo sapiens_hsa047400.67107876
91Epstein-Barr virus infection_Homo sapiens_hsa051690.66065068
92Selenocompound metabolism_Homo sapiens_hsa004500.64978953
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63497651
94Long-term depression_Homo sapiens_hsa047300.62794199
95Dorso-ventral axis formation_Homo sapiens_hsa043200.62307272
96Ether lipid metabolism_Homo sapiens_hsa005650.61350516
97Serotonergic synapse_Homo sapiens_hsa047260.61083323
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59309098
99Cholinergic synapse_Homo sapiens_hsa047250.56999701
100Herpes simplex infection_Homo sapiens_hsa051680.56813152
101Alcoholism_Homo sapiens_hsa050340.56188567
102Linoleic acid metabolism_Homo sapiens_hsa005910.56016282
103Protein digestion and absorption_Homo sapiens_hsa049740.55642872
104cAMP signaling pathway_Homo sapiens_hsa040240.55175212
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54850566
106FoxO signaling pathway_Homo sapiens_hsa040680.50600340
107beta-Alanine metabolism_Homo sapiens_hsa004100.49059184
108HIF-1 signaling pathway_Homo sapiens_hsa040660.48269845
109Amphetamine addiction_Homo sapiens_hsa050310.46775142
110Huntingtons disease_Homo sapiens_hsa050160.46749562
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45612922
112Thyroid hormone synthesis_Homo sapiens_hsa049180.45370943
113Renal cell carcinoma_Homo sapiens_hsa052110.45357015
114Fatty acid metabolism_Homo sapiens_hsa012120.44922828
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.44463503
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43748172
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43488751
118Ribosome_Homo sapiens_hsa030100.42979440
119Biosynthesis of amino acids_Homo sapiens_hsa012300.42974283
120Pancreatic cancer_Homo sapiens_hsa052120.42225177
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40930430
122Purine metabolism_Homo sapiens_hsa002300.39669891
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35682622
124Glioma_Homo sapiens_hsa052140.35008767
125AMPK signaling pathway_Homo sapiens_hsa041520.34449682
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33626447
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30867004
128Amoebiasis_Homo sapiens_hsa051460.28707408
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28403926
130Dilated cardiomyopathy_Homo sapiens_hsa054140.28255850
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27966356
132Non-small cell lung cancer_Homo sapiens_hsa052230.27351977
133Estrogen signaling pathway_Homo sapiens_hsa049150.27126771
134Ras signaling pathway_Homo sapiens_hsa040140.26297994
135Glucagon signaling pathway_Homo sapiens_hsa049220.25380191
136Ovarian steroidogenesis_Homo sapiens_hsa049130.25181014
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.25062305
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24018765
139MAPK signaling pathway_Homo sapiens_hsa040100.23164905
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22259836
141Renin-angiotensin system_Homo sapiens_hsa046140.21662145
142Fatty acid biosynthesis_Homo sapiens_hsa000610.21388947
143Proteasome_Homo sapiens_hsa030500.21113002
144Gap junction_Homo sapiens_hsa045400.19856455
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17784629
146ErbB signaling pathway_Homo sapiens_hsa040120.17576256
147Insulin signaling pathway_Homo sapiens_hsa049100.17391707

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