IL18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hypersensitivity (GO:0002883)6.15566961
2axon ensheathment in central nervous system (GO:0032291)5.54759378
3central nervous system myelination (GO:0022010)5.54759378
4positive regulation of mast cell activation involved in immune response (GO:0033008)5.25672643
5positive regulation of mast cell degranulation (GO:0043306)5.25672643
6neutrophil activation involved in immune response (GO:0002283)5.11969202
7positive regulation of cellular amide metabolic process (GO:0034250)5.08915096
8positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.86052225
9positive regulation of leukocyte degranulation (GO:0043302)4.45454506
10positive regulation of mast cell activation (GO:0033005)4.41677378
11immunoglobulin mediated immune response (GO:0016064)4.38748378
12regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.32962205
13necroptotic process (GO:0070266)4.32540419
14* positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.19894468
15L-amino acid import (GO:0043092)4.08288498
16fatty acid elongation (GO:0030497)4.06131304
17low-density lipoprotein particle remodeling (GO:0034374)3.91167337
18response to peptidoglycan (GO:0032494)3.87857111
19positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.85309649
20C4-dicarboxylate transport (GO:0015740)3.82755758
21* regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.72088545
22regulation of mast cell degranulation (GO:0043304)3.70318752
23positive regulation by symbiont of host defense response (GO:0052509)3.64980697
24modulation by symbiont of host defense response (GO:0052031)3.64980697
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64980697
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64980697
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.64980697
28modulation by symbiont of host immune response (GO:0052553)3.64980697
29regulation of inflammatory response to antigenic stimulus (GO:0002861)3.63526843
30B cell mediated immunity (GO:0019724)3.62323414
31amino acid import (GO:0043090)3.57125289
32microglial cell activation (GO:0001774)3.56745225
33programmed necrotic cell death (GO:0097300)3.55818408
34regulation of mast cell activation involved in immune response (GO:0033006)3.48294823
35negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.43724292
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37342746
37cholesterol biosynthetic process (GO:0006695)3.37029997
38negative regulation of astrocyte differentiation (GO:0048712)3.34596688
39interferon-gamma-mediated signaling pathway (GO:0060333)3.32948891
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30557023
41negative regulation of myeloid cell apoptotic process (GO:0033033)3.26132724
42very long-chain fatty acid metabolic process (GO:0000038)3.23671943
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.23057029
44regulation of chemokine biosynthetic process (GO:0045073)3.22190829
45* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19927384
46necrotic cell death (GO:0070265)3.19181198
47keratinization (GO:0031424)3.16403323
48regulation of interferon-beta biosynthetic process (GO:0045357)3.14513129
49negative regulation of interleukin-12 production (GO:0032695)3.12679601
50purine ribonucleotide transport (GO:0015868)3.11415974
51regulation of leukocyte degranulation (GO:0043300)3.11070118
52regulation of mast cell activation (GO:0033003)3.10753202
53positive regulation of antigen processing and presentation (GO:0002579)3.08973007
54phospholipid efflux (GO:0033700)3.06141591
55regulation of vitamin metabolic process (GO:0030656)3.05756782
56cellular response to cholesterol (GO:0071397)3.04117041
57regulation of vitamin D biosynthetic process (GO:0060556)3.02267506
58reverse cholesterol transport (GO:0043691)2.99984801
59mature B cell differentiation involved in immune response (GO:0002313)2.98379376
60sterol biosynthetic process (GO:0016126)2.97600939
61positive regulation of endothelial cell apoptotic process (GO:2000353)2.97253627
62granulocyte activation (GO:0036230)2.95490070
63myeloid cell activation involved in immune response (GO:0002275)2.94384867
64L-serine transport (GO:0015825)2.92975421
65sphingosine metabolic process (GO:0006670)2.92682111
66purine nucleotide transport (GO:0015865)2.92151204
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90522016
68oligodendrocyte differentiation (GO:0048709)2.89869327
69serine transport (GO:0032329)2.88961439
70regulation of metalloenzyme activity (GO:0048552)2.88102485
71negative regulation of nitric oxide biosynthetic process (GO:0045019)2.87510615
72positive regulation of acute inflammatory response (GO:0002675)2.86520505
73neutrophil activation (GO:0042119)2.85449312
74regulation of podosome assembly (GO:0071801)2.85250516
75establishment of skin barrier (GO:0061436)2.84341525
76long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83797916
77cellular response to interferon-gamma (GO:0071346)2.83789193
78cellular anion homeostasis (GO:0030002)2.83678777
79detection of other organism (GO:0098543)2.83445521
80lipoxygenase pathway (GO:0019372)2.82581879
81regulation of cholesterol esterification (GO:0010872)2.80447220
82regulation of cholesterol biosynthetic process (GO:0045540)2.79683353
83regulation of antigen processing and presentation (GO:0002577)2.77285448
84defense response to protozoan (GO:0042832)2.77225673
85cellular response to zinc ion (GO:0071294)2.76744407
86autophagic vacuole fusion (GO:0000046)2.76401757
87daunorubicin metabolic process (GO:0044597)2.75787665
88polyketide metabolic process (GO:0030638)2.75787665
89doxorubicin metabolic process (GO:0044598)2.75787665
90positive regulation of regulated secretory pathway (GO:1903307)2.75430482
91regulation of interferon-alpha production (GO:0032647)2.74460781
92regulation of heat generation (GO:0031650)2.73620632
93response to auditory stimulus (GO:0010996)2.73030031
94adenine nucleotide transport (GO:0051503)2.72355074
95response to host immune response (GO:0052572)2.71482487
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.71482487
97alpha-linolenic acid metabolic process (GO:0036109)2.71098429
98negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.71086836
99regulation of beta-amyloid formation (GO:1902003)2.70961532
100response to protozoan (GO:0001562)2.70681163
101linoleic acid metabolic process (GO:0043651)2.70513739
102response to interferon-gamma (GO:0034341)2.70310868
103eosinophil chemotaxis (GO:0048245)2.68844527
104positive regulation of prostaglandin secretion (GO:0032308)2.68166802
105diol metabolic process (GO:0034311)2.68123550
106ceramide catabolic process (GO:0046514)2.67893228
107L-serine metabolic process (GO:0006563)2.67135476
108regulation of monocyte chemotaxis (GO:0090025)2.66816674
109neurotransmitter-gated ion channel clustering (GO:0072578)2.65859057
110regulation of mononuclear cell migration (GO:0071675)2.65292923
111protein-lipid complex remodeling (GO:0034368)2.65160557
112macromolecular complex remodeling (GO:0034367)2.65160557
113plasma lipoprotein particle remodeling (GO:0034369)2.65160557
114* T-helper 1 type immune response (GO:0042088)2.64099512
115positive regulation of interleukin-10 production (GO:0032733)2.62624074
116regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.61423726
117positive regulation of immunoglobulin mediated immune response (GO:0002891)2.61111150
118positive regulation of B cell mediated immunity (GO:0002714)2.61111150
119sulfur amino acid catabolic process (GO:0000098)2.60634988
120glycosphingolipid catabolic process (GO:0046479)2.58933880
121hydrogen peroxide biosynthetic process (GO:0050665)2.57777802
122detection of bacterium (GO:0016045)2.57523233
123myelin maintenance (GO:0043217)2.57290813
124negative regulation of interleukin-17 production (GO:0032700)2.56154943
125cellular response to sterol (GO:0036315)2.55321870
126myelination (GO:0042552)2.54839262
127positive regulation of interferon-alpha production (GO:0032727)2.54541086
128positive regulation of monocyte chemotaxis (GO:0090026)2.53726331
129leukotriene biosynthetic process (GO:0019370)2.52615104
130cyclooxygenase pathway (GO:0019371)2.51958488
131ensheathment of neurons (GO:0007272)2.51930864
132axon ensheathment (GO:0008366)2.51930864
133positive regulation of T-helper cell differentiation (GO:0045624)2.51473806
134negative regulation of response to reactive oxygen species (GO:1901032)2.51302864
135nucleotide transport (GO:0006862)2.51288946
136fatty-acyl-CoA biosynthetic process (GO:0046949)2.50676837
137positive regulation of interferon-beta production (GO:0032728)2.50097336
138high-density lipoprotein particle remodeling (GO:0034375)2.49160556
139sphingomyelin metabolic process (GO:0006684)2.49065379
140positive regulation of type 2 immune response (GO:0002830)2.48716767
141very-low-density lipoprotein particle assembly (GO:0034379)2.48470514
142positive regulation of defense response to virus by host (GO:0002230)2.48321534
143positive regulation of heat generation (GO:0031652)2.47197269
144sphingoid metabolic process (GO:0046519)2.46973278
145cellular response to cadmium ion (GO:0071276)2.46870599
146eosinophil migration (GO:0072677)2.46853024
147cellular response to exogenous dsRNA (GO:0071360)2.46288425
148intracellular pH reduction (GO:0051452)2.45889600
149G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.45341075
150regulation of prostaglandin secretion (GO:0032306)2.45156195
151regulation of cellular amide metabolic process (GO:0034248)2.44471236
152plasma lipoprotein particle organization (GO:0071827)2.44090198
153positive regulation of interleukin-6 production (GO:0032755)2.43249505
154response to host (GO:0075136)2.43207140
155response to host defenses (GO:0052200)2.43207140
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43207140
157phagocytosis, engulfment (GO:0006911)2.43032132
158macrophage chemotaxis (GO:0048246)2.42315818
159regulation of water loss via skin (GO:0033561)2.41950316
160adhesion of symbiont to host cell (GO:0044650)2.38445255
161virion attachment to host cell (GO:0019062)2.38445255
162alanine transport (GO:0032328)2.37644975
163flavonoid metabolic process (GO:0009812)2.37096071
164cerebral cortex radially oriented cell migration (GO:0021799)2.36804723
165regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.36445089
166long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.36123107
167cholesterol efflux (GO:0033344)2.35520737
168regulation of astrocyte differentiation (GO:0048710)2.35520717
169positive regulation of chemokine biosynthetic process (GO:0045080)2.35282293
170plasma lipoprotein particle assembly (GO:0034377)2.32011925
171cellular ketone body metabolic process (GO:0046950)2.31360730
172regulation of cholesterol metabolic process (GO:0090181)2.31265775
173macrophage activation involved in immune response (GO:0002281)2.30446961
174protein-lipid complex subunit organization (GO:0071825)2.30168935
175photoreceptor cell differentiation (GO:0046530)2.29741302
176eye photoreceptor cell differentiation (GO:0001754)2.29741302
177acidic amino acid transport (GO:0015800)2.29306565
178nucleotide transmembrane transport (GO:1901679)2.28883337
179neurotransmitter uptake (GO:0001504)2.27188169
180response to lipoprotein particle (GO:0055094)2.24682076
181positive regulation of fatty acid transport (GO:2000193)2.24443150
182negative regulation of sterol transport (GO:0032372)2.23340717
183negative regulation of cholesterol transport (GO:0032375)2.23340717
184cellular potassium ion homeostasis (GO:0030007)2.20907893
185thioester biosynthetic process (GO:0035384)2.19068815
186acyl-CoA biosynthetic process (GO:0071616)2.19068815
187nonribosomal peptide biosynthetic process (GO:0019184)2.18774431
188positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.18568726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.51968448
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19215489
3RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.02126256
4GATA1_22025678_ChIP-Seq_K562_Human2.99041538
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92736915
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.59195828
7SCL_19346495_ChIP-Seq_HPC-7_Human2.52332911
8ZNF263_19887448_ChIP-Seq_K562_Human2.37194566
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28652953
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28646140
11GBX2_23144817_ChIP-Seq_PC3_Human2.25038025
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22674723
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18562495
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13114383
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07466881
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07283683
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06395001
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.05353773
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02297368
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01744024
21AR_21572438_ChIP-Seq_LNCaP_Human2.00731043
22SPI1_23547873_ChIP-Seq_NB4_Human1.94167092
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93605229
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86688315
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.86244593
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83187949
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80034231
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78473556
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75527176
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.74105742
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73878340
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73878340
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68457859
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.67589757
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67421965
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65777595
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65031386
38* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.64439942
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59853484
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59460570
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.58846433
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54734725
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54551462
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53326507
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53266073
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52821946
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52392793
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51408858
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50575779
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48624362
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47506431
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.47266479
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46361593
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46361593
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46351154
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.43951281
57SPI1_23127762_ChIP-Seq_K562_Human1.43793691
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41176550
59* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39033173
60* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37499399
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37310718
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37282250
63GATA4_25053715_ChIP-Seq_YYC3_Human1.35904722
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34324977
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.33607899
66MYB_26560356_Chip-Seq_TH2_Human1.32668558
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31999601
68TAF15_26573619_Chip-Seq_HEK293_Human1.31979656
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31013725
70VDR_24763502_ChIP-Seq_THP-1_Human1.29683864
71HTT_18923047_ChIP-ChIP_STHdh_Human1.27999122
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27774130
73STAT1_20625510_ChIP-Seq_HELA_Human1.27666357
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26988581
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26490292
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25293468
77RXR_22108803_ChIP-Seq_LS180_Human1.24929654
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.23582954
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22458252
80* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22382957
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21242659
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.18385091
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17826993
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17826993
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.16649775
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.16246588
87P300_19829295_ChIP-Seq_ESCs_Human1.15314072
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.15156074
89GATA3_26560356_Chip-Seq_TH2_Human1.14480300
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13784844
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13160288
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12573175
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12439582
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11893612
95DROSHA_22980978_ChIP-Seq_HELA_Human1.10081704
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09880461
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09583011
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07274747
99PU_27001747_Chip-Seq_BMDM_Mouse1.07257536
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06435260
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.05443618
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05193202
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04982105
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02616983
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02557947
106TP53_16413492_ChIP-PET_HCT116_Human1.02487579
107SOX2_20726797_ChIP-Seq_SW620_Human1.02273222
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02256474
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02254807
110GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01730956
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01301258
112LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00740300
113ATF3_27146783_Chip-Seq_COLON_Human0.99387852
114TP53_18474530_ChIP-ChIP_U2OS_Human0.98253031
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97459893
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97388649
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97132747
118TAL1_26923725_Chip-Seq_HPCs_Mouse0.96836638
119VDR_22108803_ChIP-Seq_LS180_Human0.96182574
120AR_25329375_ChIP-Seq_VCAP_Human0.95772445
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95514484
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93605705
123BCAT_22108803_ChIP-Seq_LS180_Human0.93362750
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93124564
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92936577
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92609449
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92327446
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92031244
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91476837
130RUNX_20019798_ChIP-Seq_JUKART_Human0.91469978
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91153408
132VDR_21846776_ChIP-Seq_THP-1_Human0.91104890
133* TP63_23658742_ChIP-Seq_EP156T_Human0.91099479
134GATA3_27048872_Chip-Seq_THYMUS_Human0.91002187
135GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89186274
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88861111
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88384595
138BP1_19119308_ChIP-ChIP_Hs578T_Human0.87666335
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.87046828
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86405409
141* CJUN_26792858_Chip-Seq_BT549_Human0.86404605
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86398142
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.86090687
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85805425
145VDR_24787735_ChIP-Seq_THP-1_Human0.85797688
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85699199
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85664824
148STAT3_18555785_Chip-Seq_ESCs_Mouse0.85214873
149ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84819388
150* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84781688
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84506318
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84455084
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.84303362
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.83187198
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.83043029
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82923475
157FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.82734685
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.82699126
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82683202
160ER_23166858_ChIP-Seq_MCF-7_Human0.82556313
161E2F1_18555785_Chip-Seq_ESCs_Mouse0.82239585
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82239312
163GATA6_25053715_ChIP-Seq_YYC3_Human0.81736878
164P53_22387025_ChIP-Seq_ESCs_Mouse0.81345198
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.81071554
166TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80463784
167SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80328694
168CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80187261
169GATA6_21074721_ChIP-Seq_CACO-2_Human0.79723722
170BCL6_27268052_Chip-Seq_Bcells_Human0.76752650
171SPI1_20517297_ChIP-Seq_HL60_Human0.75981377
172E2F1_20622854_ChIP-Seq_HELA_Human0.75626076
173TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75594985
174BCOR_27268052_Chip-Seq_Bcells_Human0.75540875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.95822555
2MP0003690_abnormal_glial_cell3.40648078
3MP0005360_urolithiasis3.02764919
4MP0003303_peritoneal_inflammation2.84694142
5MP0002254_reproductive_system_inflammat2.80683639
6MP0003436_decreased_susceptibility_to2.55503708
7MP0003191_abnormal_cellular_cholesterol2.38287290
8MP0000920_abnormal_myelination2.34286171
9MP0002139_abnormal_hepatobiliary_system2.31469295
10MP0003329_amyloid_beta_deposits2.28335351
11MP0003183_abnormal_peptide_metabolism2.26948822
12MP0010234_abnormal_vibrissa_follicle2.25446673
13MP0003136_yellow_coat_color2.23521841
14MP0000566_synostosis2.09699311
15MP0003011_delayed_dark_adaptation2.02828295
16MP0001800_abnormal_humoral_immune2.00170218
17MP0005058_abnormal_lysosome_morphology1.99743042
18MP0009384_cardiac_valve_regurgitation1.93417025
19MP0000343_altered_response_to1.90566798
20MP0009333_abnormal_splenocyte_physiolog1.87133847
21MP0008875_abnormal_xenobiotic_pharmacok1.86394530
22MP0002234_abnormal_pharynx_morphology1.86271312
23MP0002723_abnormal_immune_serum1.85829305
24MP0003300_gastrointestinal_ulcer1.84823132
25MP0005451_abnormal_body_composition1.83655210
26MP0000604_amyloidosis1.82915268
27MP0003453_abnormal_keratinocyte_physiol1.81590494
28MP0001853_heart_inflammation1.75926779
29MP0009764_decreased_sensitivity_to1.73228231
30MP0005646_abnormal_pituitary_gland1.69003863
31MP0003806_abnormal_nucleotide_metabolis1.68048369
32* MP0003075_altered_response_to1.68027447
33MP0001486_abnormal_startle_reflex1.66848755
34* MP0001845_abnormal_inflammatory_respons1.62906060
35MP0001819_abnormal_immune_cell1.62645212
36MP0002090_abnormal_vision1.62396043
37MP0002420_abnormal_adaptive_immunity1.60964097
38MP0000685_abnormal_immune_system1.59411584
39MP0001835_abnormal_antigen_presentation1.58128016
40MP0003950_abnormal_plasma_membrane1.56641876
41* MP0001873_stomach_inflammation1.56143057
42MP0003880_abnormal_central_pattern1.55356579
43MP0005171_absent_coat_pigmentation1.55235522
44MP0006082_CNS_inflammation1.54068706
45MP0009785_altered_susceptibility_to1.49951635
46MP0005397_hematopoietic_system_phenotyp1.49539705
47MP0001545_abnormal_hematopoietic_system1.49539705
48MP0004885_abnormal_endolymph1.47364505
49MP0001533_abnormal_skeleton_physiology1.45444624
50MP0000858_altered_metastatic_potential1.40757939
51MP0002405_respiratory_system_inflammati1.40375169
52* MP0002419_abnormal_innate_immunity1.39341065
53MP0001666_abnormal_nutrient_absorption1.38716259
54MP0004858_abnormal_nervous_system1.37887165
55MP0003656_abnormal_erythrocyte_physiolo1.37409402
56MP0001216_abnormal_epidermal_layer1.37133428
57MP0005551_abnormal_eye_electrophysiolog1.35718895
58* MP0003634_abnormal_glial_cell1.34627823
59MP0002796_impaired_skin_barrier1.33378310
60MP0005332_abnormal_amino_acid1.33017911
61MP0002148_abnormal_hypersensitivity_rea1.32903316
62MP0004510_myositis1.28828995
63MP0003252_abnormal_bile_duct1.27740153
64MP0010329_abnormal_lipoprotein_level1.26301709
65MP0009278_abnormal_bone_marrow1.26156502
66MP0001790_abnormal_immune_system1.25909564
67MP0005387_immune_system_phenotype1.25909564
68MP0001984_abnormal_olfaction1.24645782
69MP0003878_abnormal_ear_physiology1.24107493
70MP0005377_hearing/vestibular/ear_phenot1.24107493
71MP0005501_abnormal_skin_physiology1.23390380
72MP0003633_abnormal_nervous_system1.23387762
73MP0001501_abnormal_sleep_pattern1.22710734
74MP0001502_abnormal_circadian_rhythm1.22342751
75MP0003448_altered_tumor_morphology1.20564011
76MP0002118_abnormal_lipid_homeostasis1.18926362
77MP0005085_abnormal_gallbladder_physiolo1.18382700
78MP0005365_abnormal_bile_salt1.18295144
79MP0002998_abnormal_bone_remodeling1.15733623
80MP0004947_skin_inflammation1.13987671
81MP0002876_abnormal_thyroid_physiology1.13200103
82MP0003763_abnormal_thymus_physiology1.12961325
83MP0004142_abnormal_muscle_tone1.12737136
84MP0008004_abnormal_stomach_pH1.11446186
85* MP0005025_abnormal_response_to1.10940213
86MP0004742_abnormal_vestibular_system1.10890392
87MP0005023_abnormal_wound_healing1.09453066
88* MP0000716_abnormal_immune_system1.08560093
89MP0001851_eye_inflammation1.08011791
90MP0001905_abnormal_dopamine_level1.07029051
91MP0009379_abnormal_foot_pigmentation1.06576915
92MP0002736_abnormal_nociception_after1.03891641
93MP0005584_abnormal_enzyme/coenzyme_acti1.03409572
94MP0002064_seizures1.02800236
95MP0004782_abnormal_surfactant_physiolog1.01278290
96* MP0005166_decreased_susceptibility_to1.00705465
97MP0005670_abnormal_white_adipose1.00291301
98MP0009780_abnormal_chondrocyte_physiolo1.00167987
99MP0002229_neurodegeneration0.99369703
100MP0001440_abnormal_grooming_behavior0.96366763
101MP0005464_abnormal_platelet_physiology0.96184352
102MP0003631_nervous_system_phenotype0.95669301
103MP0004883_abnormal_blood_vessel0.95054119
104MP0002138_abnormal_hepatobiliary_system0.93780573
105MP0005165_increased_susceptibility_to0.93172216
106MP0000681_abnormal_thyroid_gland0.92814454
107MP0002132_abnormal_respiratory_system0.92718237
108* MP0000465_gastrointestinal_hemorrhage0.92096941
109MP0000249_abnormal_blood_vessel0.91657107
110MP0005167_abnormal_blood-brain_barrier0.91610377
111MP0005671_abnormal_response_to0.91260845
112MP0002398_abnormal_bone_marrow0.90228175
113MP0000383_abnormal_hair_follicle0.90120163
114MP0009643_abnormal_urine_homeostasis0.89340528
115MP0009763_increased_sensitivity_to0.89149094
116MP0004019_abnormal_vitamin_homeostasis0.88832648
117MP0003172_abnormal_lysosome_physiology0.88528453
118MP0004130_abnormal_muscle_cell0.88264935
119MP0001764_abnormal_homeostasis0.87572579
120MP0003724_increased_susceptibility_to0.87367951
121MP0002272_abnormal_nervous_system0.86280644
122MP0000647_abnormal_sebaceous_gland0.86146077
123* MP0001664_abnormal_digestion0.86061935
124MP0001485_abnormal_pinna_reflex0.85915804
125MP0002006_tumorigenesis0.84960571
126MP0005000_abnormal_immune_tolerance0.84403997
127MP0004808_abnormal_hematopoietic_stem0.84379512
128MP0009765_abnormal_xenobiotic_induced0.84358359
129MP0002098_abnormal_vibrissa_morphology0.84301504
130* MP0002429_abnormal_blood_cell0.83838474
131* MP0001663_abnormal_digestive_system0.83372923
132* MP0008469_abnormal_protein_level0.83077458
133MP0003632_abnormal_nervous_system0.81655416
134MP0005310_abnormal_salivary_gland0.81301652
135MP0002332_abnormal_exercise_endurance0.80470667
136MP0001529_abnormal_vocalization0.79244353
137MP0004043_abnormal_pH_regulation0.79174854
138MP0005164_abnormal_response_to0.79153618
139MP0001986_abnormal_taste_sensitivity0.78904183
140MP0009745_abnormal_behavioral_response0.78011341
141MP0004270_analgesia0.77381874
142* MP0002452_abnormal_antigen_presenting0.77364721
143MP0009697_abnormal_copulation0.76949315
144MP0005319_abnormal_enzyme/_coenzyme0.76740505
145MP0010678_abnormal_skin_adnexa0.76709104
146MP0003186_abnormal_redox_activity0.75775870
147MP0000689_abnormal_spleen_morphology0.75674014
148MP0000579_abnormal_nail_morphology0.75673536
149MP0002396_abnormal_hematopoietic_system0.74719120
150MP0005666_abnormal_adipose_tissue0.74686603
151MP0001191_abnormal_skin_condition0.73887333
152MP0003868_abnormal_feces_composition0.73818122
153MP0010155_abnormal_intestine_physiology0.73585435
154MP0005595_abnormal_vascular_smooth0.72979442
155MP0005410_abnormal_fertilization0.72260046
156MP0002877_abnormal_melanocyte_morpholog0.71863142
157MP0002822_catalepsy0.71852907

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.10044218
2Neurofibrillary tangles (HP:0002185)5.48513269
3Abnormality of glycolipid metabolism (HP:0010969)4.97231498
4Abnormality of liposaccharide metabolism (HP:0010968)4.97231498
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.97231498
6Autoimmune hemolytic anemia (HP:0001890)4.87819956
7Increased IgM level (HP:0003496)4.36126483
8Aplasia involving bones of the upper limbs (HP:0009823)4.27808507
9Aplasia of the phalanges of the hand (HP:0009802)4.27808507
10Aplasia involving bones of the extremities (HP:0009825)4.27808507
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.89934503
12Hyperlipoproteinemia (HP:0010980)3.57328349
13Cerebral inclusion bodies (HP:0100314)3.54638994
14Lip pit (HP:0100267)3.53100933
15Megalencephaly (HP:0001355)3.52842720
16Disinhibition (HP:0000734)3.41702963
17Eczematoid dermatitis (HP:0000976)3.37330374
18Clumsiness (HP:0002312)3.34527529
19Abnormality of secondary sexual hair (HP:0009888)3.21725834
20Abnormality of the axillary hair (HP:0100134)3.21725834
21Plantar hyperkeratosis (HP:0007556)2.98438294
22Palmoplantar hyperkeratosis (HP:0000972)2.95235492
23Pustule (HP:0200039)2.92209798
24Increased IgE level (HP:0003212)2.91392920
25Intrahepatic cholestasis (HP:0001406)2.90073188
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.86622095
27Stomatitis (HP:0010280)2.85991120
28Amyloidosis (HP:0011034)2.84958661
29Abnormality of T cell number (HP:0011839)2.81868884
30Xanthomatosis (HP:0000991)2.81550581
31Abnormality of macrophages (HP:0004311)2.81459406
32Humeroradial synostosis (HP:0003041)2.78188750
33Synostosis involving the elbow (HP:0003938)2.78188750
34Enlarged epiphyses (HP:0010580)2.75538942
35Hypoplastic left heart (HP:0004383)2.74475203
36Palmar hyperkeratosis (HP:0010765)2.71829083
37Paraparesis (HP:0002385)2.71686891
38Hypergammaglobulinemia (HP:0010702)2.70989776
39Parakeratosis (HP:0001036)2.68599909
40Vacuolated lymphocytes (HP:0001922)2.67819844
41Supranuclear gaze palsy (HP:0000605)2.64167460
42Thick nail (HP:0001805)2.60248403
43Alopecia of scalp (HP:0002293)2.59340395
44Onycholysis (HP:0001806)2.56957217
45Hyperventilation (HP:0002883)2.55143390
46Eosinophilia (HP:0001880)2.54993008
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54297986
48Corneal erosion (HP:0200020)2.51972677
49Neonatal hypoglycemia (HP:0001998)2.49546603
50Hypochromic anemia (HP:0001931)2.48509917
51Recurrent abscess formation (HP:0002722)2.48204308
52Vasculitis (HP:0002633)2.47593843
53Oral leukoplakia (HP:0002745)2.47557767
54Increased cerebral lipofuscin (HP:0011813)2.47510492
55Patchy hypopigmentation of hair (HP:0011365)2.42756501
56Congenital ichthyosiform erythroderma (HP:0007431)2.42742849
57Progressive neurologic deterioration (HP:0002344)2.42714753
58Myositis (HP:0100614)2.42044855
59Abnormality of the middle phalanges of the toes (HP:0010183)2.41979089
60Abnormality of T cell physiology (HP:0011840)2.38764694
61Split foot (HP:0001839)2.38535008
62Spastic paraparesis (HP:0002313)2.37065149
63Erythema (HP:0010783)2.36055024
64Hemiparesis (HP:0001269)2.33890428
65Agammaglobulinemia (HP:0004432)2.33502433
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30993771
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30993771
68Recurrent bacterial skin infections (HP:0005406)2.29757482
69Obstructive lung disease (HP:0006536)2.28378544
70Chronic obstructive pulmonary disease (HP:0006510)2.28378544
71Abnormal blistering of the skin (HP:0008066)2.28227184
72Hypotrichosis (HP:0001006)2.28215765
73Granulocytopenia (HP:0001913)2.28129677
74Septate vagina (HP:0001153)2.26954447
75Dry hair (HP:0011359)2.25085872
76Short hallux (HP:0010109)2.24938569
77Orchitis (HP:0100796)2.24397778
78Tetraparesis (HP:0002273)2.23416632
79Hypoplastic heart (HP:0001961)2.23316844
80White forelock (HP:0002211)2.23022089
81Milia (HP:0001056)2.22777013
82Loss of speech (HP:0002371)2.22529969
83Mixed hearing impairment (HP:0000410)2.21467574
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21191038
85Xerostomia (HP:0000217)2.20816645
86Flat occiput (HP:0005469)2.17385868
87Symphalangism affecting the phalanges of the hand (HP:0009773)2.16319636
88Elevated erythrocyte sedimentation rate (HP:0003565)2.15075026
89Ridged nail (HP:0001807)2.15044560
90Glomerulonephritis (HP:0000099)2.13597575
91Abnormality of nail color (HP:0100643)2.13107534
92Recurrent gram-negative bacterial infections (HP:0005420)2.11451402
93Nail dystrophy (HP:0008404)2.09453390
94Ectropion (HP:0000656)2.07653984
95Retrobulbar optic neuritis (HP:0100654)2.07538080
96Optic neuritis (HP:0100653)2.07538080
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07239666
98Glucose intolerance (HP:0000833)2.07140656
99Erythroderma (HP:0001019)2.06734466
100Methylmalonic acidemia (HP:0002912)2.05953470
101Aplasia/Hypoplasia of the hallux (HP:0008362)2.03516147
102Abnormality of the prostate (HP:0008775)2.02890029
103Meningitis (HP:0001287)2.01900692
104Malnutrition (HP:0004395)1.97482081
105Dysostosis multiplex (HP:0000943)1.95281253
106Partial duplication of thumb phalanx (HP:0009944)1.95184144
107Keratoconjunctivitis (HP:0001096)1.94457291
108Increased serum ferritin (HP:0003281)1.93816797
109Axonal loss (HP:0003447)1.93083587
110Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92146030
111Abnormality of polysaccharide metabolism (HP:0011012)1.92146030
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92146030
113Cheilitis (HP:0100825)1.91750072
114Skin rash (HP:0000988)1.91116629
115Prostate neoplasm (HP:0100787)1.89485476
116Pulmonary infiltrates (HP:0002113)1.88441073
117Neoplasm of head and neck (HP:0012288)1.88209484
118Esophageal neoplasm (HP:0100751)1.88209484
119Petechiae (HP:0000967)1.88165645
120Conjugated hyperbilirubinemia (HP:0002908)1.87528809
121Mutism (HP:0002300)1.87477793
122Retinal dysplasia (HP:0007973)1.87138016
123Methylmalonic aciduria (HP:0012120)1.87114380
124Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86699315
125Premature loss of primary teeth (HP:0006323)1.85849863
126Prolonged partial thromboplastin time (HP:0003645)1.83158024
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.82227553
128Recurrent skin infections (HP:0001581)1.81988950
129Abnormality of T cells (HP:0002843)1.81984122
130Complement deficiency (HP:0004431)1.81909278
131Urticaria (HP:0001025)1.81657927
132Metabolic alkalosis (HP:0200114)1.80533084
133Thickened helices (HP:0000391)1.80040713
134Decreased circulating renin level (HP:0003351)1.79897386
135Constricted visual fields (HP:0001133)1.79862104
136Hepatosplenomegaly (HP:0001433)1.79216886
137Abnormality of B cell number (HP:0010975)1.79045466
138Chronic otitis media (HP:0000389)1.78456275
139Dehydration (HP:0001944)1.78390329
140Polyneuropathy (HP:0001271)1.78007113
141Sparse eyelashes (HP:0000653)1.77259860
142Sensorimotor neuropathy (HP:0007141)1.76615273
143Woolly hair (HP:0002224)1.76576191
144Abnormality of serine family amino acid metabolism (HP:0010894)1.76415594
145Abnormality of glycine metabolism (HP:0010895)1.76415594
146Gangrene (HP:0100758)1.76322608
147Long nose (HP:0003189)1.74361992
148Basal ganglia calcification (HP:0002135)1.74107100
149Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73912590
150Abnormality of the dental pulp (HP:0006479)1.73762967
151Hypoalphalipoproteinemia (HP:0003233)1.72541146
152Systemic lupus erythematosus (HP:0002725)1.72345335
153Abnormality of binocular vision (HP:0011514)1.71630768
154Diplopia (HP:0000651)1.71630768
155Abolished electroretinogram (ERG) (HP:0000550)1.69505476
156Epileptic encephalopathy (HP:0200134)1.68612249
157Hemiplegia (HP:0002301)1.67353373
158Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.66529919
159Conical tooth (HP:0000698)1.65930532
160Slow saccadic eye movements (HP:0000514)1.65889455
161Abnormality of permanent molar morphology (HP:0011071)1.65718506
162Abnormality of the dental root (HP:0006486)1.65718506
163Taurodontia (HP:0000679)1.65718506
164Broad alveolar ridges (HP:0000187)1.65557374
165Abnormality of the 2nd finger (HP:0004100)1.65446604
166Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64744499
167Fat malabsorption (HP:0002630)1.63352498
168Hypolipoproteinemia (HP:0010981)1.63284968
169Poor suck (HP:0002033)1.62006678
170Fragile nails (HP:0001808)1.61932046
171Mediastinal lymphadenopathy (HP:0100721)1.60691585
172Coronal craniosynostosis (HP:0004440)1.58736964
173Abnormality of molar morphology (HP:0011070)1.58635024
174Abnormality of molar (HP:0011077)1.58635024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.44060675
2TNIK4.48442754
3MUSK3.83105475
4NME23.55271379
5LMTK22.96221571
6CASK2.81574692
7EPHB12.75485087
8IRAK32.48625776
9PBK2.42328007
10EPHA42.32819467
11GRK72.10475606
12MAP4K22.09997491
13MST42.08385371
14PHKG22.07625393
15PHKG12.07625393
16MAPKAPK52.05091984
17MAP3K141.86923332
18EPHA21.86086829
19OXSR11.84381417
20STK391.82651989
21PRPF4B1.79913519
22RIPK41.73181165
23EIF2AK31.71753830
24MST1R1.66758624
25FGR1.59933424
26TAOK31.57967329
27MET1.54307657
28STK101.52509137
29KIT1.48213420
30SIK11.47114395
31TBK11.42171392
32CDK31.39944230
33NEK61.30752235
34MAP2K61.29540668
35ABL21.27172622
36NTRK21.24288703
37MAP3K61.22225799
38PIM21.18322045
39PKN11.18208137
40MOS1.17222768
41MAP3K131.16303103
42TYK21.16009171
43BLK1.14980811
44TAOK21.14772840
45MAP2K31.14639394
46CSF1R1.13322938
47CDK191.12348595
48PIK3CA1.12064020
49IKBKE1.11682379
50ERBB41.11567149
51ZAP701.11009167
52ADRBK21.09699849
53TESK21.09170181
54MAPK121.09099255
55TRPM71.07133632
56MAP2K71.03742720
57BCKDK0.97663737
58CAMKK20.96964701
59FLT30.92991296
60ERN10.91903725
61TXK0.90960960
62MAP3K120.90641756
63MAPK70.90519652
64SGK2230.89513039
65SGK4940.89513039
66PRKCQ0.87952150
67MAP3K30.84979531
68YES10.84071168
69EIF2AK20.83167466
70CAMK2D0.82973717
71FES0.82156870
72JAK30.81561955
73CAMK2G0.81437943
74MAPK130.81031920
75PINK10.80822004
76BMPR1B0.80574760
77MAP3K70.79115224
78PRKCE0.78904829
79CAMK1D0.78195607
80IRAK40.78162125
81GRK60.71840605
82LYN0.70696573
83TGFBR20.68866433
84PDK20.68772245
85BMPR20.68202046
86EPHB20.67994944
87CAMK2B0.67393268
88PRKG20.66864094
89MAP3K20.66736051
90TGFBR10.65287343
91IKBKB0.64176795
92PTK20.63250299
93ARAF0.63035080
94STK240.61799260
95SCYL20.61009382
96MAP3K110.59838950
97TEC0.58413715
98MKNK20.57608817
99CAMK2A0.56518984
100BTK0.54620213
101STK160.54472306
102MARK30.54393013
103ACVR1B0.54289982
104IRAK10.53284542
105MAP4K10.53248107
106BMX0.52883695
107PIK3CG0.51345460
108EIF2AK10.51027249
109PRKAA20.49458598
110IGF1R0.49292098
111MKNK10.49176978
112FYN0.48789971
113PRKD30.48504264
114MAP3K50.48286262
115MATK0.48260833
116PDPK10.48130538
117ROCK20.47069938
118HCK0.46016060
119MAPK40.45062286
120TESK10.44991852
121ADRBK10.44265182
122JAK20.43856089
123ABL10.43391662
124SYK0.42576590
125LCK0.42560636
126PRKCA0.42077892
127ERBB30.41299341
128RPS6KB20.40256352
129PDGFRB0.39993591
130FGFR20.39983569
131PRKCD0.39764295
132CSK0.38199028
133ITK0.38004430
134CSNK1G20.37932353
135GRK10.37705617
136MARK20.35701577
137CDK50.35676889
138MAPK110.35632464
139JAK10.35479280
140PAK30.35384362
141CHUK0.35036506
142PDK10.34389328
143PRKD10.34265776
144NTRK10.34010136
145INSR0.27893759
146CDK60.26224229
147EGFR0.24229827
148ILK0.24111039
149MAPKAPK30.22711112
150MYLK0.20498091

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.58276634
2Nitrogen metabolism_Homo sapiens_hsa009103.97209615
3Autoimmune thyroid disease_Homo sapiens_hsa053203.80698125
4Steroid biosynthesis_Homo sapiens_hsa001003.42856455
5Type I diabetes mellitus_Homo sapiens_hsa049403.42815569
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.10528076
7Sulfur metabolism_Homo sapiens_hsa009203.06613226
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73809428
9Fatty acid elongation_Homo sapiens_hsa000622.71349515
10Fatty acid biosynthesis_Homo sapiens_hsa000612.26952939
11Antigen processing and presentation_Homo sapiens_hsa046122.04550925
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04188096
13Fatty acid metabolism_Homo sapiens_hsa012121.99178708
14Caffeine metabolism_Homo sapiens_hsa002321.86979875
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.83442757
16Ether lipid metabolism_Homo sapiens_hsa005651.82903792
17Histidine metabolism_Homo sapiens_hsa003401.78359548
18Fatty acid degradation_Homo sapiens_hsa000711.69134799
19Vitamin digestion and absorption_Homo sapiens_hsa049771.67848658
20Mineral absorption_Homo sapiens_hsa049781.67785598
21Peroxisome_Homo sapiens_hsa041461.65132494
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59960016
23Sphingolipid metabolism_Homo sapiens_hsa006001.58526649
24* Influenza A_Homo sapiens_hsa051641.58257440
25Viral myocarditis_Homo sapiens_hsa054161.56424089
26* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55563515
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55062196
28Hematopoietic cell lineage_Homo sapiens_hsa046401.54274705
29Toxoplasmosis_Homo sapiens_hsa051451.54227607
30Osteoclast differentiation_Homo sapiens_hsa043801.47209189
31Staphylococcus aureus infection_Homo sapiens_hsa051501.37834992
32Butanoate metabolism_Homo sapiens_hsa006501.36960813
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36515032
34* Legionellosis_Homo sapiens_hsa051341.36255946
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33455113
36Chemical carcinogenesis_Homo sapiens_hsa052041.33201044
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31319768
38TNF signaling pathway_Homo sapiens_hsa046681.29219024
39Herpes simplex infection_Homo sapiens_hsa051681.27117148
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25968064
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24932032
42PPAR signaling pathway_Homo sapiens_hsa033201.23912230
43Propanoate metabolism_Homo sapiens_hsa006401.21334002
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.21198686
45Ribosome_Homo sapiens_hsa030101.18746266
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17200629
47ABC transporters_Homo sapiens_hsa020101.16374403
48Complement and coagulation cascades_Homo sapiens_hsa046101.16141035
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12468034
50Lysosome_Homo sapiens_hsa041421.11452262
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09881731
52Linoleic acid metabolism_Homo sapiens_hsa005911.09569768
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04825849
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04488261
55Retinol metabolism_Homo sapiens_hsa008301.02977729
56Bile secretion_Homo sapiens_hsa049761.02690808
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01934305
58Fat digestion and absorption_Homo sapiens_hsa049751.01593667
59* Salmonella infection_Homo sapiens_hsa051321.01360202
60Fructose and mannose metabolism_Homo sapiens_hsa000510.98369379
61Measles_Homo sapiens_hsa051620.98041574
62Systemic lupus erythematosus_Homo sapiens_hsa053220.97853000
63* Malaria_Homo sapiens_hsa051440.95422928
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.91244627
65Arachidonic acid metabolism_Homo sapiens_hsa005900.90823474
66Tryptophan metabolism_Homo sapiens_hsa003800.85589455
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.84112247
68Arginine and proline metabolism_Homo sapiens_hsa003300.81537250
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81076631
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77839634
71B cell receptor signaling pathway_Homo sapiens_hsa046620.75252243
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74709077
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74663675
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74049715
75* African trypanosomiasis_Homo sapiens_hsa051430.74032429
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73372416
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.73214670
78Glutathione metabolism_Homo sapiens_hsa004800.72121648
79Sulfur relay system_Homo sapiens_hsa041220.70042829
80Pertussis_Homo sapiens_hsa051330.69950860
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69816696
82Arginine biosynthesis_Homo sapiens_hsa002200.67756660
83Shigellosis_Homo sapiens_hsa051310.66960747
84GABAergic synapse_Homo sapiens_hsa047270.66895526
85beta-Alanine metabolism_Homo sapiens_hsa004100.65069336
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64124529
87Chemokine signaling pathway_Homo sapiens_hsa040620.62737772
88* Rheumatoid arthritis_Homo sapiens_hsa053230.61950496
89Leishmaniasis_Homo sapiens_hsa051400.61792758
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.61372059
91Starch and sucrose metabolism_Homo sapiens_hsa005000.61301162
92Folate biosynthesis_Homo sapiens_hsa007900.61244269
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60176228
94Pentose phosphate pathway_Homo sapiens_hsa000300.60056842
95Glutamatergic synapse_Homo sapiens_hsa047240.60019341
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.59743980
97Morphine addiction_Homo sapiens_hsa050320.59294214
98Amoebiasis_Homo sapiens_hsa051460.58565898
99Salivary secretion_Homo sapiens_hsa049700.58155711
100* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58056862
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57659959
102Glycerolipid metabolism_Homo sapiens_hsa005610.56969187
103Apoptosis_Homo sapiens_hsa042100.56047211
104Other glycan degradation_Homo sapiens_hsa005110.55938229
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53983632
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50324869
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49875568
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49651751
109Gastric acid secretion_Homo sapiens_hsa049710.46642602
110* Tuberculosis_Homo sapiens_hsa051520.44718283
111Graft-versus-host disease_Homo sapiens_hsa053320.44090829
112Metabolic pathways_Homo sapiens_hsa011000.44034285
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43818474
114* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42672651
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.42663694
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41697202
117Allograft rejection_Homo sapiens_hsa053300.41666260
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41602618
119Serotonergic synapse_Homo sapiens_hsa047260.40629820
120* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40612752
121Circadian rhythm_Homo sapiens_hsa047100.40520821
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40483508
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40229164
124Platelet activation_Homo sapiens_hsa046110.40123009
125Epstein-Barr virus infection_Homo sapiens_hsa051690.39567798
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.39098758
127Hepatitis C_Homo sapiens_hsa051600.38228557
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37116320
129Vitamin B6 metabolism_Homo sapiens_hsa007500.35942892
130Renin-angiotensin system_Homo sapiens_hsa046140.35170237
131Pancreatic secretion_Homo sapiens_hsa049720.34706787
132Prion diseases_Homo sapiens_hsa050200.34222918
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.33836633
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33832293
135Hepatitis B_Homo sapiens_hsa051610.32839518
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31970942
137Acute myeloid leukemia_Homo sapiens_hsa052210.30679684
138Primary immunodeficiency_Homo sapiens_hsa053400.30213973
139Proteasome_Homo sapiens_hsa030500.28790508
140Collecting duct acid secretion_Homo sapiens_hsa049660.26937629
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.26731505
142Phagosome_Homo sapiens_hsa041450.26408721
143Circadian entrainment_Homo sapiens_hsa047130.25717138
144Oxidative phosphorylation_Homo sapiens_hsa001900.23262159
145T cell receptor signaling pathway_Homo sapiens_hsa046600.22178061
146Galactose metabolism_Homo sapiens_hsa000520.18535582

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