IL18R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)7.36797320
2negative regulation of cell killing (GO:0031342)7.31994452
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.31994452
4negative T cell selection (GO:0043383)6.72465059
5negative thymic T cell selection (GO:0045060)6.52914674
6positive regulation of gamma-delta T cell activation (GO:0046645)6.48502081
7positive thymic T cell selection (GO:0045059)6.38589904
8cellular response to interleukin-15 (GO:0071350)5.97863120
9response to interleukin-15 (GO:0070672)5.90177985
10positive T cell selection (GO:0043368)5.89195124
11regulation of isotype switching to IgG isotypes (GO:0048302)5.86094354
12tolerance induction (GO:0002507)5.66060973
13thymic T cell selection (GO:0045061)5.62327087
14T cell migration (GO:0072678)5.55689202
15regulation of gamma-delta T cell differentiation (GO:0045586)5.31217165
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19134595
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.19134595
18T cell selection (GO:0045058)5.17416397
19regulation of gamma-delta T cell activation (GO:0046643)5.08998236
20antigen processing and presentation of endogenous antigen (GO:0019883)4.81566192
21negative regulation of T cell mediated immunity (GO:0002710)4.80878330
22leukocyte aggregation (GO:0070486)4.77929388
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43844323
24regulation of T cell tolerance induction (GO:0002664)4.43354060
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38519502
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.20968457
27regulation of natural killer cell mediated immunity (GO:0002715)4.20968457
28regulation of leukocyte mediated cytotoxicity (GO:0001910)4.19604253
29positive regulation of isotype switching (GO:0045830)4.19102356
30regulation of B cell receptor signaling pathway (GO:0050855)4.14754573
31T cell receptor signaling pathway (GO:0050852)4.12917120
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.08594559
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.07002690
34response to muramyl dipeptide (GO:0032495)4.01932889
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.00442172
36regulation of cell killing (GO:0031341)3.94100033
37activated T cell proliferation (GO:0050798)3.92214175
38T cell costimulation (GO:0031295)3.91967278
39positive regulation by symbiont of host defense response (GO:0052509)3.87544699
40modulation by symbiont of host defense response (GO:0052031)3.87544699
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.87544699
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.87544699
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.87544699
44modulation by symbiont of host immune response (GO:0052553)3.87544699
45lymphocyte costimulation (GO:0031294)3.85693373
46positive regulation of DNA recombination (GO:0045911)3.80910856
47positive regulation of natural killer cell mediated immunity (GO:0002717)3.79101419
48positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.79101419
49positive regulation of natural killer cell differentiation (GO:0032825)3.76608485
50positive regulation of cell killing (GO:0031343)3.70594445
51positive regulation of T cell mediated cytotoxicity (GO:0001916)3.69964953
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.68673645
53regulation of T cell mediated cytotoxicity (GO:0001914)3.67728225
54regulation of alpha-beta T cell proliferation (GO:0046640)3.64829859
55positive regulation of tolerance induction (GO:0002645)3.64503512
56detection of other organism (GO:0098543)3.64437084
57positive regulation of B cell mediated immunity (GO:0002714)3.63122773
58positive regulation of immunoglobulin mediated immune response (GO:0002891)3.63122773
59negative regulation of interleukin-12 production (GO:0032695)3.62876859
60positive regulation of interleukin-17 production (GO:0032740)3.62656900
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61602848
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59797479
63regulation of activation of Janus kinase activity (GO:0010533)3.59739426
64regulation of interferon-beta biosynthetic process (GO:0045357)3.58365892
65regulation of isotype switching (GO:0045191)3.58025548
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.54862014
67type I interferon signaling pathway (GO:0060337)3.51717693
68cellular response to type I interferon (GO:0071357)3.51717693
69antigen receptor-mediated signaling pathway (GO:0050851)3.49600067
70response to type I interferon (GO:0034340)3.49016720
71leukocyte cell-cell adhesion (GO:0007159)3.47413175
72detection of bacterium (GO:0016045)3.44293829
73regulation of memory T cell differentiation (GO:0043380)3.43906644
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.43587629
75negative regulation of T-helper cell differentiation (GO:0045623)3.43587629
76lymphocyte migration (GO:0072676)3.41257830
77defense response to protozoan (GO:0042832)3.40279210
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.39824565
79mast cell activation (GO:0045576)3.37904461
80neutrophil activation involved in immune response (GO:0002283)3.37599370
81positive regulation of T-helper 1 type immune response (GO:0002827)3.36964024
82regulation of tolerance induction (GO:0002643)3.35980287
83surfactant homeostasis (GO:0043129)3.33822152
84positive regulation of humoral immune response (GO:0002922)3.31947540
85* alpha-beta T cell activation (GO:0046631)3.30660608
86antigen processing and presentation via MHC class Ib (GO:0002475)3.26450464
87* T cell differentiation (GO:0030217)3.26439895
88regulation of immunoglobulin mediated immune response (GO:0002889)3.26347806
89* alpha-beta T cell differentiation (GO:0046632)3.25882019
90positive regulation of T cell mediated immunity (GO:0002711)3.25819816
91neutrophil activation (GO:0042119)3.24900090
92positive regulation of defense response to virus by host (GO:0002230)3.24172132
93NIK/NF-kappaB signaling (GO:0038061)3.24097547
94positive regulation of interleukin-2 production (GO:0032743)3.22459755
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21930174
96regulation of T cell mediated immunity (GO:0002709)3.21619510
97regulation of regulatory T cell differentiation (GO:0045589)3.21566598
98regulation of response to interferon-gamma (GO:0060330)3.20403947
99negative regulation of adaptive immune response (GO:0002820)3.19660268
100heterotypic cell-cell adhesion (GO:0034113)3.18258189
101* natural killer cell activation (GO:0030101)3.17361911
102regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.17205623
103macrophage activation involved in immune response (GO:0002281)3.15957289
104regulation of B cell mediated immunity (GO:0002712)3.15931743
105detection of external biotic stimulus (GO:0098581)3.13452814
106regulation of T cell receptor signaling pathway (GO:0050856)3.12290487
107interferon-gamma-mediated signaling pathway (GO:0060333)3.11863998
108B cell receptor signaling pathway (GO:0050853)3.11809904
109regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.11035996
110regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.10876166
111regulation of T-helper 1 type immune response (GO:0002825)3.08029928
112regulation of interleukin-17 production (GO:0032660)3.07957945
113positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07403174
114negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06739653
115cellular defense response (GO:0006968)3.06562177
116response to peptidoglycan (GO:0032494)3.05815346
117regulation of chronic inflammatory response (GO:0002676)3.05490830
118detection of molecule of bacterial origin (GO:0032490)3.03786185
119regulation of germinal center formation (GO:0002634)3.03739207
120immunoglobulin mediated immune response (GO:0016064)3.03368432
121negative regulation of leukocyte mediated immunity (GO:0002704)3.02286636
122cellular extravasation (GO:0045123)3.02179646
123response to protozoan (GO:0001562)3.01857079
124regulation of lymphocyte mediated immunity (GO:0002706)3.01376925
125positive regulation of lymphocyte mediated immunity (GO:0002708)3.00940394
126* T-helper cell differentiation (GO:0042093)3.00165670
127* CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.00165670
128germinal center formation (GO:0002467)3.00077100
129response to interferon-alpha (GO:0035455)2.99447978
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98412313
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94658637
132* T cell activation involved in immune response (GO:0002286)2.93705279
133regulation of mast cell degranulation (GO:0043304)2.93627794
134negative regulation of innate immune response (GO:0045824)2.91046523
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90618671
136* T cell activation (GO:0042110)2.90486021
137regulation of mast cell activation (GO:0033003)2.89783360
138regulation of interleukin-2 production (GO:0032663)2.88696633
139* T cell differentiation involved in immune response (GO:0002292)2.88219863
140* alpha-beta T cell differentiation involved in immune response (GO:0002293)2.88219863
141* alpha-beta T cell activation involved in immune response (GO:0002287)2.88219863
142granulocyte activation (GO:0036230)2.88008501
143positive regulation of interferon-alpha production (GO:0032727)2.87981215
144dendritic cell migration (GO:0036336)2.84538530
145positive regulation of immunoglobulin production (GO:0002639)2.83662805
146myeloid dendritic cell activation (GO:0001773)2.83597409
147T cell proliferation (GO:0042098)2.81833080
148tyrosine phosphorylation of STAT protein (GO:0007260)2.79399772
149negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78901919
150lymph node development (GO:0048535)2.78389053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.39803089
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.04600007
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.46448598
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.20365775
5RUNX_20019798_ChIP-Seq_JUKART_Human3.96377855
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.89658087
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.79853748
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.63081554
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.61618857
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.58389660
11* MYB_26560356_Chip-Seq_TH2_Human3.10292113
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87469870
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.73253466
14MYB_26560356_Chip-Seq_TH1_Human2.61414895
15MAF_26560356_Chip-Seq_TH1_Human2.48101735
16* IRF8_21731497_ChIP-ChIP_J774_Mouse2.41900180
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32867235
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.32261917
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24392963
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.23364599
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21346472
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20316195
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.11690680
24MYC_22102868_ChIP-Seq_BL_Human2.10586348
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07140411
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05102398
27UTX_26944678_Chip-Seq_JUKART_Human2.04652269
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94116173
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91965611
30SCL_19346495_ChIP-Seq_HPC-7_Human1.87756016
31* GATA3_27048872_Chip-Seq_THYMUS_Human1.86256742
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77385522
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.74672115
34TCF7_22412390_ChIP-Seq_EML_Mouse1.64677057
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.63162104
36MAF_26560356_Chip-Seq_TH2_Human1.54500521
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48033319
38SPI1_23547873_ChIP-Seq_NB4_Human1.45745924
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42000887
40VDR_21846776_ChIP-Seq_THP-1_Human1.39720235
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38079970
42* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36300831
43VDR_24763502_ChIP-Seq_THP-1_Human1.34116805
44* GATA3_26560356_Chip-Seq_TH2_Human1.30019211
45SPI1_23127762_ChIP-Seq_K562_Human1.27126411
46* PU_27001747_Chip-Seq_BMDM_Mouse1.26999412
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26509328
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26447874
49VDR_24787735_ChIP-Seq_THP-1_Human1.26197845
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24602326
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.23724742
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13346858
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11258503
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09295691
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08937106
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07816401
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06866116
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06476639
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.04696238
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.04408313
61GATA1_22025678_ChIP-Seq_K562_Human1.03406922
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03188078
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02761077
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02198097
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00300637
66GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99027432
67* KDM2B_26808549_Chip-Seq_DND41_Human0.98985929
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98463348
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97877926
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96919930
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95070455
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94409158
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93636994
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93477444
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91732165
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90995342
77* NFE2_27457419_Chip-Seq_LIVER_Mouse0.90573618
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89491610
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88474364
80* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87963131
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87276050
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87276050
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86356900
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86346457
85TCF4_18268006_ChIP-ChIP_LS174T_Human0.85798005
86* GATA3_26560356_Chip-Seq_TH1_Human0.85708211
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85539989
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84206466
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83812284
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83181752
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83019754
92* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81212621
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81205103
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80698270
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79772121
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79113595
97GATA1_19941826_ChIP-Seq_K562_Human0.78789705
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78433249
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.78368477
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78296453
101* GATA2_19941826_ChIP-Seq_K562_Human0.76714383
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76449202
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74464267
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72633856
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72600335
106PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71816487
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71396523
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71084478
109SMRT_27268052_Chip-Seq_Bcells_Human0.70809910
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.70808084
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70321919
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69776287
113IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69277448
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.68889888
115* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68188922
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.68006626
117* FLI1_27457419_Chip-Seq_LIVER_Mouse0.67383259
118* EZH2_27294783_Chip-Seq_NPCs_Mouse0.66231204
119GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.64724997
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.64375009
121* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63770627
122SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.63613417
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.62566699
124CJUN_26792858_Chip-Seq_BT549_Human0.62383532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.58858486
2MP0003763_abnormal_thymus_physiology4.57221775
3MP0000685_abnormal_immune_system3.56155346
4MP0001835_abnormal_antigen_presentation3.39567004
5MP0005387_immune_system_phenotype3.16204339
6MP0001790_abnormal_immune_system3.16204339
7MP0009785_altered_susceptibility_to3.08853797
8MP0001800_abnormal_humoral_immune2.93234144
9MP0005000_abnormal_immune_tolerance2.78070817
10MP0006082_CNS_inflammation2.77728097
11MP0003724_increased_susceptibility_to2.70701948
12MP0001873_stomach_inflammation2.67490279
13* MP0002723_abnormal_immune_serum2.67384616
14* MP0002420_abnormal_adaptive_immunity2.65834441
15* MP0001819_abnormal_immune_cell2.64579566
16MP0002405_respiratory_system_inflammati2.64486793
17MP0004782_abnormal_surfactant_physiolog2.52729135
18MP0005025_abnormal_response_to2.47407658
19MP0002452_abnormal_antigen_presenting2.45755078
20MP0003436_decreased_susceptibility_to2.33261361
21MP0002398_abnormal_bone_marrow2.32470943
22MP0002166_altered_tumor_susceptibility2.28521640
23MP0010155_abnormal_intestine_physiology2.26183783
24MP0002148_abnormal_hypersensitivity_rea2.20853626
25MP0000716_abnormal_immune_system2.17732801
26MP0009333_abnormal_splenocyte_physiolog2.11812946
27MP0002132_abnormal_respiratory_system2.11673496
28MP0002006_tumorigenesis2.11555167
29MP0002277_abnormal_respiratory_mucosa2.08255187
30MP0000703_abnormal_thymus_morphology2.03182382
31MP0002419_abnormal_innate_immunity2.01438255
32MP0003866_abnormal_defecation2.00793502
33MP0004947_skin_inflammation1.99734123
34MP0002396_abnormal_hematopoietic_system1.96085513
35MP0002722_abnormal_immune_system1.85135840
36MP0000858_altered_metastatic_potential1.80139882
37MP0003448_altered_tumor_morphology1.70434449
38MP0002429_abnormal_blood_cell1.70283388
39MP0001845_abnormal_inflammatory_respons1.69223474
40MP0000689_abnormal_spleen_morphology1.66939931
41MP0003300_gastrointestinal_ulcer1.65554033
42MP0002933_joint_inflammation1.63594039
43MP0004510_myositis1.59952704
44MP0005310_abnormal_salivary_gland1.58930925
45MP0005464_abnormal_platelet_physiology1.57493546
46MP0001851_eye_inflammation1.56471222
47MP0003191_abnormal_cellular_cholesterol1.46727593
48MP0002138_abnormal_hepatobiliary_system1.45545883
49MP0000465_gastrointestinal_hemorrhage1.45519749
50MP0002009_preneoplasia1.35810276
51MP0001853_heart_inflammation1.34259120
52MP0004381_abnormal_hair_follicle1.32333726
53MP0002998_abnormal_bone_remodeling1.29657203
54MP0000490_abnormal_crypts_of1.22957163
55MP0001533_abnormal_skeleton_physiology1.20056662
56MP0008260_abnormal_autophagy1.13818986
57MP0003303_peritoneal_inflammation1.11437835
58MP0003656_abnormal_erythrocyte_physiolo1.09313723
59MP0001545_abnormal_hematopoietic_system1.07669975
60MP0005397_hematopoietic_system_phenotyp1.07669975
61MP0004808_abnormal_hematopoietic_stem1.06399968
62MP0003045_fibrosis1.05762523
63MP0008469_abnormal_protein_level1.03549119
64MP0002254_reproductive_system_inflammat0.99732173
65MP0003453_abnormal_keratinocyte_physiol0.99046800
66MP0004883_abnormal_blood_vessel0.98752629
67MP0009764_decreased_sensitivity_to0.95235715
68MP0008995_early_reproductive_senescence0.95183213
69MP0005075_abnormal_melanosome_morpholog0.90860066
70MP0000604_amyloidosis0.89897258
71MP0008004_abnormal_stomach_pH0.89022143
72MP0003075_altered_response_to0.87115985
73MP0005164_abnormal_response_to0.85765402
74MP0001881_abnormal_mammary_gland0.85488106
75MP0009765_abnormal_xenobiotic_induced0.85043285
76MP0000566_synostosis0.83350804
77MP0001216_abnormal_epidermal_layer0.80415436
78MP0010352_gastrointestinal_tract_polyps0.80025159
79MP0008961_abnormal_basal_metabolism0.78742221
80MP0002019_abnormal_tumor_incidence0.77470572
81MP0001958_emphysema0.77305981
82MP0005451_abnormal_body_composition0.76792490
83MP0001663_abnormal_digestive_system0.72657602
84MP0000343_altered_response_to0.72437607
85MP0003172_abnormal_lysosome_physiology0.71192534
86MP0003828_pulmonary_edema0.67009778
87MP0005166_decreased_susceptibility_to0.64214891
88MP0005023_abnormal_wound_healing0.63855977
89MP0003566_abnormal_cell_adhesion0.63332173
90MP0001346_abnormal_lacrimal_gland0.63321578
91MP0003795_abnormal_bone_structure0.63084568
92MP0003252_abnormal_bile_duct0.62266617
93MP0000609_abnormal_liver_physiology0.60884095
94MP0009840_abnormal_foam_cell0.60734869
95MP0000249_abnormal_blood_vessel0.60668193
96MP0002136_abnormal_kidney_physiology0.60518558
97MP0001849_ear_inflammation0.60133998
98MP0000627_abnormal_mammary_gland0.59518129
99MP0005174_abnormal_tail_pigmentation0.59213719
100MP0001191_abnormal_skin_condition0.58241448
101MP0009278_abnormal_bone_marrow0.58201417
102MP0010307_abnormal_tumor_latency0.58001480
103MP0002877_abnormal_melanocyte_morpholog0.56221586
104MP0001501_abnormal_sleep_pattern0.56213624
105MP0005076_abnormal_cell_differentiation0.55195194
106MP0000383_abnormal_hair_follicle0.54997873
107MP0002133_abnormal_respiratory_system0.54778877
108MP0005388_respiratory_system_phenotype0.54778877
109MP0002876_abnormal_thyroid_physiology0.54359426
110MP0002163_abnormal_gland_morphology0.54272040
111MP0009763_increased_sensitivity_to0.53424533
112MP0003091_abnormal_cell_migration0.53409793
113MP0005390_skeleton_phenotype0.52895423
114MP0005319_abnormal_enzyme/_coenzyme0.52514471
115MP0008007_abnormal_cellular_replicative0.49966898
116MP0003787_abnormal_imprinting0.49266430
117MP0004484_altered_response_of0.48833392
118MP0000477_abnormal_intestine_morphology0.47611509
119MP0000569_abnormal_digit_pigmentation0.47151291
120MP0001243_abnormal_dermal_layer0.46876489
121MP0003195_calcinosis0.46625646
122MP0005083_abnormal_biliary_tract0.46501698
123MP0003183_abnormal_peptide_metabolism0.43783552
124MP0000367_abnormal_coat/_hair0.43411727
125MP0003690_abnormal_glial_cell0.42795567
126MP0005167_abnormal_blood-brain_barrier0.42724152

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.42465513
2Optic neuritis (HP:0100653)6.42465513
3Myositis (HP:0100614)5.90005217
4T lymphocytopenia (HP:0005403)5.67351023
5Orchitis (HP:0100796)5.62914272
6Abnormality of T cell number (HP:0011839)5.56449380
7Keratoconjunctivitis (HP:0001096)4.36239985
8Nasal polyposis (HP:0100582)4.29116467
9Keratoconjunctivitis sicca (HP:0001097)4.28265263
10Abnormality of T cells (HP:0002843)4.14669924
11Interstitial pulmonary disease (HP:0006530)3.97363258
12IgM deficiency (HP:0002850)3.95748706
13Abnormality of the nasal mucosa (HP:0000433)3.95333278
14Recurrent fungal infections (HP:0002841)3.93997429
15Recurrent bronchitis (HP:0002837)3.89646770
16Chronic otitis media (HP:0000389)3.83273825
17Eczematoid dermatitis (HP:0000976)3.80874539
18Recurrent cutaneous fungal infections (HP:0011370)3.74777151
19Chronic mucocutaneous candidiasis (HP:0002728)3.74777151
20Elevated erythrocyte sedimentation rate (HP:0003565)3.72510565
21Severe combined immunodeficiency (HP:0004430)3.72142403
22Pustule (HP:0200039)3.58507347
23Pulmonary infiltrates (HP:0002113)3.54744965
24Abnormality of the fingertips (HP:0001211)3.53709733
25Hemoptysis (HP:0002105)3.51104130
26Arterial thrombosis (HP:0004420)3.42816338
27Stomatitis (HP:0010280)3.42291637
28Encephalitis (HP:0002383)3.41882961
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.41209131
30Vasculitis (HP:0002633)3.37590727
31Combined immunodeficiency (HP:0005387)3.29100821
32Chronic diarrhea (HP:0002028)3.15736413
33Recurrent gram-negative bacterial infections (HP:0005420)3.10519046
34Joint swelling (HP:0001386)3.09806680
35IgG deficiency (HP:0004315)3.07905103
36Meningitis (HP:0001287)3.07608173
37Abnormality of eosinophils (HP:0001879)3.05682794
38Stomach cancer (HP:0012126)2.93717105
39Recurrent viral infections (HP:0004429)2.90392521
40Thyroiditis (HP:0100646)2.86382338
41Panhypogammaglobulinemia (HP:0003139)2.83487785
42Spontaneous hematomas (HP:0007420)2.77759785
43Abnormality of T cell physiology (HP:0011840)2.77192441
44Increased IgE level (HP:0003212)2.75188256
45Bronchitis (HP:0012387)2.74699320
46Increased IgM level (HP:0003496)2.73678448
47Premature loss of primary teeth (HP:0006323)2.72920295
48Gangrene (HP:0100758)2.71594349
49Recurrent abscess formation (HP:0002722)2.67259305
50Autoimmune hemolytic anemia (HP:0001890)2.66418357
51Eosinophilia (HP:0001880)2.65528305
52Keratitis (HP:0000491)2.64064514
53Pulmonary embolism (HP:0002204)2.63339566
54Leukocytosis (HP:0001974)2.63300036
55Lymphopenia (HP:0001888)2.61120663
56IgA deficiency (HP:0002720)2.59701162
57Urticaria (HP:0001025)2.52260525
58Mediastinal lymphadenopathy (HP:0100721)2.50687489
59B lymphocytopenia (HP:0010976)2.49301700
60Abnormality of B cell number (HP:0010975)2.49301700
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.49241652
62Autoimmune thrombocytopenia (HP:0001973)2.42925391
63Cheilitis (HP:0100825)2.39359346
64Prolonged bleeding time (HP:0003010)2.38169782
65Hypochromic anemia (HP:0001931)2.36622058
66Increased density of long bones (HP:0006392)2.35975854
67Persistence of primary teeth (HP:0006335)2.33168082
68Anorexia (HP:0002039)2.31280682
69Gastrointestinal infarctions (HP:0005244)2.29678378
70Obstructive lung disease (HP:0006536)2.27478256
71Chronic obstructive pulmonary disease (HP:0006510)2.27478256
72Recurrent skin infections (HP:0001581)2.26902005
73Granulocytopenia (HP:0001913)2.22081017
74Episodic fever (HP:0001954)2.18497042
75Vertigo (HP:0002321)2.17741178
76Inflammation of the large intestine (HP:0002037)2.17257211
77Abnormality of macrophages (HP:0004311)2.16779719
78Peritonitis (HP:0002586)2.16139657
79Abnormality of the prostate (HP:0008775)2.15858313
80Hypergammaglobulinemia (HP:0010702)2.15185391
81Glomerulopathy (HP:0100820)2.14057954
82Recurrent sinusitis (HP:0011108)2.13926918
83Osteomyelitis (HP:0002754)2.12078356
84Lip pit (HP:0100267)2.11913598
85Sepsis (HP:0100806)2.10263494
86Anhidrosis (HP:0000970)2.07762928
87Abnormality of the endocardium (HP:0004306)2.06327608
88Bronchiectasis (HP:0002110)2.04877304
89Lymphoma (HP:0002665)2.03587277
90Chronic sinusitis (HP:0011109)2.02543312
91Recurrent bacterial skin infections (HP:0005406)2.01575719
92Acute hepatic failure (HP:0006554)2.01346672
93Hypochromic microcytic anemia (HP:0004840)2.00958160
94Abnormality of the pleura (HP:0002103)2.00927403
95Skin rash (HP:0000988)1.99895120
96Epistaxis (HP:0000421)1.99711693
97Gastrointestinal inflammation (HP:0004386)1.98177546
98Periodontitis (HP:0000704)1.96659664
99Agammaglobulinemia (HP:0004432)1.89296526
100Ureteral stenosis (HP:0000071)1.88620218
101Prostate neoplasm (HP:0100787)1.87215975
102Polyneuropathy (HP:0001271)1.87036026
103Thrombophlebitis (HP:0004418)1.86892132
104Arthralgia (HP:0002829)1.84961268
105Alveolar cell carcinoma (HP:0006519)1.82649356
106Abnormality of the pericardium (HP:0001697)1.80436565
107Ureteral obstruction (HP:0006000)1.79444103
108Acne (HP:0001061)1.79036244
109Chest pain (HP:0100749)1.76933818
110Gingivitis (HP:0000230)1.76038569
111Skin ulcer (HP:0200042)1.74920577
112Hyperactive renin-angiotensin system (HP:0000841)1.74507936
113Aseptic necrosis (HP:0010885)1.74133558
114Gingival bleeding (HP:0000225)1.73915608
115Gastrointestinal stroma tumor (HP:0100723)1.72455058
116Hypoplasia of the thymus (HP:0000778)1.68445147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.53729924
2MAP4K14.37898413
3ITK3.38043263
4RIPK43.36667680
5JAK32.95137692
6MAP3K142.89792978
7JAK12.63412879
8FGFR42.58067543
9IRAK32.51570393
10ZAP702.48201744
11STK102.47973778
12FGFR32.28500853
13IKBKE2.28352081
14MAP2K22.24817504
15TYK22.11206412
16TAOK32.08148314
17SIK32.00882857
18TEC1.99699150
19NME11.78781473
20TGFBR21.77113897
21MST41.74194050
22NLK1.72705956
23EPHA31.60956832
24CSK1.56508511
25TBK11.53209880
26IRAK41.51310321
27MATK1.47766759
28LCK1.44269312
29EPHB11.43709293
30STK241.43212969
31IKBKB1.42760165
32GRK61.36475471
33BTK1.36119263
34MARK31.32025533
35CHUK1.25463929
36NUAK11.24813155
37HCK1.20700388
38PRKCQ1.17241172
39MAP3K131.16122367
40PIM11.11873764
41SYK1.11373740
42SIK21.08841169
43CDK121.04894815
44TNK21.00906559
45FGR0.90881623
46RPS6KA40.90527666
47FGFR20.87805159
48ERN10.87343899
49TRPM70.87229746
50BLK0.87185747
51GRK70.85191224
52MAP3K120.83896374
53BRD40.83895419
54JAK20.82691590
55TLK10.82238803
56PRKCH0.78324298
57LRRK20.77635756
58MAP3K70.74137040
59PDGFRB0.73270079
60TSSK60.72992355
61KIT0.72040929
62IRAK10.71614296
63PIK3CG0.68112909
64ACVR1B0.67513049
65FES0.65905236
66MAPK150.65739778
67MELK0.64725754
68EEF2K0.64424698
69RAF10.64335864
70TESK20.64317722
71CLK10.62616690
72DMPK0.61376201
73LYN0.61072728
74MAP2K60.55980667
75NEK90.55752161
76MAP3K60.55364182
77CDK80.55351391
78WNK10.54178976
79CDC42BPA0.52257720
80SIK10.51804076
81KDR0.51766901
82PDK10.50488228
83PTK2B0.48581276
84FRK0.48240114
85CDK90.48075983
86CDK60.47616837
87MAP2K10.47215250
88RPS6KC10.46542004
89RPS6KL10.46542004
90SGK30.44600928
91PRKD20.43918166
92KSR20.43873728
93CDK40.43624836
94IGF1R0.43260466
95MAPK120.43200497
96ADRBK20.40628863
97MAPKAPK20.39866843
98HIPK20.39494523
99MAP3K30.36504447
100GRK10.36409577
101YES10.34962610
102CDK30.34054333
103SGK20.33633379
104PRPF4B0.33323012
105TYRO30.32446544
106RPS6KA20.31609642
107MAPK70.30534459
108MAP3K100.30523351
109TIE10.30401260
110IRAK20.30201777
111PTK60.30049742
112MAP3K50.29934379
113MAPK40.29734031
114MAP3K10.29304975
115RPS6KA50.29283618
116STK30.28827609
117EIF2AK20.28297173
118INSR0.27553660
119PRKCD0.27268044
120EGFR0.26585718
121MARK20.26530737
122CAMKK20.25767721
123BMPR20.24364485
124MAP2K30.24106236
125STK40.23697636
126ABL10.22060039
127FYN0.20725155
128GSK3A0.19129828
129RPS6KA60.18304666
130CSF1R0.17664404
131MAPK110.17567273
132MAPK30.17196811

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.23023266
2* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.73756803
3Graft-versus-host disease_Homo sapiens_hsa053323.35932773
4T cell receptor signaling pathway_Homo sapiens_hsa046602.99717391
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.89460836
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.69710279
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.66203358
8Allograft rejection_Homo sapiens_hsa053302.60643493
9Measles_Homo sapiens_hsa051622.54334328
10Autoimmune thyroid disease_Homo sapiens_hsa053202.37113690
11Antigen processing and presentation_Homo sapiens_hsa046122.29053484
12Osteoclast differentiation_Homo sapiens_hsa043802.07829687
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.99833980
14Leishmaniasis_Homo sapiens_hsa051401.99182671
15Hematopoietic cell lineage_Homo sapiens_hsa046401.86050993
16* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60569787
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59195081
18Viral myocarditis_Homo sapiens_hsa054161.56674103
19Toxoplasmosis_Homo sapiens_hsa051451.54901367
20B cell receptor signaling pathway_Homo sapiens_hsa046621.51790597
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47450749
22Herpes simplex infection_Homo sapiens_hsa051681.46719496
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.44599474
24* TNF signaling pathway_Homo sapiens_hsa046681.42842699
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40576520
26Chemokine signaling pathway_Homo sapiens_hsa040621.38320093
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33555865
28Influenza A_Homo sapiens_hsa051641.30622104
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29151630
30Type I diabetes mellitus_Homo sapiens_hsa049401.23012489
31Hepatitis B_Homo sapiens_hsa051611.21209801
32Apoptosis_Homo sapiens_hsa042101.20775192
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18198114
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17393666
35Acute myeloid leukemia_Homo sapiens_hsa052211.16589939
36Pancreatic cancer_Homo sapiens_hsa052121.11078692
37Malaria_Homo sapiens_hsa051441.06439501
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04724232
39Prolactin signaling pathway_Homo sapiens_hsa049171.03039333
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02278446
41HTLV-I infection_Homo sapiens_hsa051661.01286542
42Rheumatoid arthritis_Homo sapiens_hsa053231.00557627
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99873985
44Shigellosis_Homo sapiens_hsa051310.95367833
45Hepatitis C_Homo sapiens_hsa051600.92784309
46Platelet activation_Homo sapiens_hsa046110.87093016
47Small cell lung cancer_Homo sapiens_hsa052220.85358811
48Tuberculosis_Homo sapiens_hsa051520.84386581
49Chronic myeloid leukemia_Homo sapiens_hsa052200.83143644
50Legionellosis_Homo sapiens_hsa051340.82120240
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81974340
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79828194
53Asthma_Homo sapiens_hsa053100.79658481
54Staphylococcus aureus infection_Homo sapiens_hsa051500.76619954
55Colorectal cancer_Homo sapiens_hsa052100.75639444
56Pertussis_Homo sapiens_hsa051330.75396333
57Circadian rhythm_Homo sapiens_hsa047100.75317494
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71242530
59VEGF signaling pathway_Homo sapiens_hsa043700.70645096
60Epstein-Barr virus infection_Homo sapiens_hsa051690.69982679
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69016077
62Salmonella infection_Homo sapiens_hsa051320.67411741
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66461107
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65699712
65Adherens junction_Homo sapiens_hsa045200.64171695
66Phagosome_Homo sapiens_hsa041450.63103962
67FoxO signaling pathway_Homo sapiens_hsa040680.62825107
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61931509
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.59616061
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57396386
71p53 signaling pathway_Homo sapiens_hsa041150.56630404
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.56620745
73Viral carcinogenesis_Homo sapiens_hsa052030.56039686
74Notch signaling pathway_Homo sapiens_hsa043300.55516229
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54878993
76Regulation of autophagy_Homo sapiens_hsa041400.51962126
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.49488493
78Prostate cancer_Homo sapiens_hsa052150.49461495
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49244483
80MAPK signaling pathway_Homo sapiens_hsa040100.48126596
81Endocytosis_Homo sapiens_hsa041440.47967558
82Rap1 signaling pathway_Homo sapiens_hsa040150.47308512
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46010134
84Inositol phosphate metabolism_Homo sapiens_hsa005620.44754012
85Pathways in cancer_Homo sapiens_hsa052000.43501061
86Other glycan degradation_Homo sapiens_hsa005110.43398907
87Dorso-ventral axis formation_Homo sapiens_hsa043200.43303942
88Non-small cell lung cancer_Homo sapiens_hsa052230.41448232
89Endometrial cancer_Homo sapiens_hsa052130.41041313
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40820688
91Renal cell carcinoma_Homo sapiens_hsa052110.40648067
92MicroRNAs in cancer_Homo sapiens_hsa052060.39111933
93Focal adhesion_Homo sapiens_hsa045100.38751130
94Arachidonic acid metabolism_Homo sapiens_hsa005900.37367963
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37031151
96Caffeine metabolism_Homo sapiens_hsa002320.34747085
97Insulin resistance_Homo sapiens_hsa049310.31165019
98Lysosome_Homo sapiens_hsa041420.29517278
99Complement and coagulation cascades_Homo sapiens_hsa046100.27890099
100Choline metabolism in cancer_Homo sapiens_hsa052310.27107295
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26860749
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26782446
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26642295
104Proteoglycans in cancer_Homo sapiens_hsa052050.26256645
105HIF-1 signaling pathway_Homo sapiens_hsa040660.26172695
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.25070193
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24777534
108ECM-receptor interaction_Homo sapiens_hsa045120.24346039
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24222066
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24221728
111Linoleic acid metabolism_Homo sapiens_hsa005910.24073969
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24070310
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23728605
114Amoebiasis_Homo sapiens_hsa051460.22664716
115African trypanosomiasis_Homo sapiens_hsa051430.22374687
116Ras signaling pathway_Homo sapiens_hsa040140.22113445
117Systemic lupus erythematosus_Homo sapiens_hsa053220.21408083
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.18121970
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16222230
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15813757
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13550587
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09757420
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09363161

Most similar genes based on co-expression Upload to Enrichr

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