IL18RAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)7.02288466
2positive regulation of gamma-delta T cell activation (GO:0046645)6.49516389
3leukocyte aggregation (GO:0070486)6.20418878
4negative regulation of cell killing (GO:0031342)6.19988044
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.19988044
6T cell migration (GO:0072678)5.75793422
7cellular response to interleukin-15 (GO:0071350)5.31528996
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.20382034
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.20382034
10modulation by symbiont of host immune response (GO:0052553)5.20382034
11positive regulation by symbiont of host defense response (GO:0052509)5.20382034
12modulation by symbiont of host defense response (GO:0052031)5.20382034
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.20382034
14negative T cell selection (GO:0043383)5.20360511
15response to interleukin-15 (GO:0070672)5.14757942
16negative thymic T cell selection (GO:0045060)5.10833273
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03994521
18activated T cell proliferation (GO:0050798)4.94551315
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.77856637
20regulation of B cell receptor signaling pathway (GO:0050855)4.76392009
21regulation of gamma-delta T cell differentiation (GO:0045586)4.73263718
22regulation of natural killer cell mediated immunity (GO:0002715)4.68035375
23regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.68035375
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59791455
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59791455
26regulation of gamma-delta T cell activation (GO:0046643)4.52489050
27detection of other organism (GO:0098543)4.47058163
28positive thymic T cell selection (GO:0045059)4.45291654
29regulation of isotype switching to IgG isotypes (GO:0048302)4.38609752
30leukocyte cell-cell adhesion (GO:0007159)4.35080979
31macrophage activation involved in immune response (GO:0002281)4.34951814
32cellular extravasation (GO:0045123)4.30952041
33detection of molecule of bacterial origin (GO:0032490)4.27807048
34leukocyte migration involved in inflammatory response (GO:0002523)4.25171446
35cellular defense response (GO:0006968)4.15824905
36detection of bacterium (GO:0016045)4.12410016
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.11530167
38regulation of B cell differentiation (GO:0045577)4.08911484
39negative regulation of interleukin-12 production (GO:0032695)4.07237180
40detection of external biotic stimulus (GO:0098581)4.03086691
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.01442629
42natural killer cell activation (GO:0030101)3.98757448
43regulation of interferon-beta biosynthetic process (GO:0045357)3.98684349
44positive regulation of isotype switching (GO:0045830)3.97935515
45regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.95391578
46thymic T cell selection (GO:0045061)3.94569310
47response to peptidoglycan (GO:0032494)3.94278920
48antigen processing and presentation of endogenous antigen (GO:0019883)3.90326311
49positive T cell selection (GO:0043368)3.90156577
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.86224123
51negative regulation of T-helper cell differentiation (GO:0045623)3.86224123
52negative regulation of leukocyte mediated immunity (GO:0002704)3.85714110
53response to host immune response (GO:0052572)3.82854451
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82854451
55microglial cell activation (GO:0001774)3.81464890
56neutrophil activation (GO:0042119)3.78466604
57positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.76421418
58positive regulation of natural killer cell mediated immunity (GO:0002717)3.76421418
59regulation of leukocyte mediated cytotoxicity (GO:0001910)3.75526082
60cellular response to type I interferon (GO:0071357)3.68811909
61type I interferon signaling pathway (GO:0060337)3.68811909
62response to type I interferon (GO:0034340)3.65924364
63dendritic cell chemotaxis (GO:0002407)3.63600694
64respiratory burst (GO:0045730)3.58686659
65neutrophil mediated immunity (GO:0002446)3.57729117
66regulation of cell killing (GO:0031341)3.55504361
67detection of biotic stimulus (GO:0009595)3.53570024
68T cell selection (GO:0045058)3.52578341
69negative regulation of T cell mediated immunity (GO:0002710)3.52559970
70positive regulation of DNA recombination (GO:0045911)3.50816013
71lymphocyte migration (GO:0072676)3.50400007
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50192701
73response to host (GO:0075136)3.50192701
74response to host defenses (GO:0052200)3.50192701
75myeloid cell activation involved in immune response (GO:0002275)3.49274235
76dendritic cell migration (GO:0036336)3.47390728
77mast cell activation (GO:0045576)3.47296480
78germinal center formation (GO:0002467)3.46755027
79granulocyte activation (GO:0036230)3.43736727
80positive regulation of B cell mediated immunity (GO:0002714)3.42720802
81positive regulation of immunoglobulin mediated immune response (GO:0002891)3.42720802
82production of molecular mediator involved in inflammatory response (GO:0002532)3.42472111
83antigen processing and presentation via MHC class Ib (GO:0002475)3.42064630
84regulation of T cell chemotaxis (GO:0010819)3.41638850
85positive regulation of T cell chemotaxis (GO:0010820)3.41638850
86heterotypic cell-cell adhesion (GO:0034113)3.40850830
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40184540
88macrophage activation (GO:0042116)3.38727942
89tolerance induction (GO:0002507)3.36762896
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.35628321
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.34020449
92response to muramyl dipeptide (GO:0032495)3.30358344
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24928622
94immunoglobulin mediated immune response (GO:0016064)3.22066298
95leukocyte degranulation (GO:0043299)3.20516020
96T cell proliferation (GO:0042098)3.20030002
97myeloid leukocyte mediated immunity (GO:0002444)3.19166555
98positive regulation of cell killing (GO:0031343)3.17222571
99leukocyte tethering or rolling (GO:0050901)3.16861898
100T cell activation involved in immune response (GO:0002286)3.16509201
101T cell receptor signaling pathway (GO:0050852)3.16392829
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16184460
103regulation of activation of Janus kinase activity (GO:0010533)3.15388944
104negative regulation of alpha-beta T cell activation (GO:0046636)3.14074139
105neutrophil activation involved in immune response (GO:0002283)3.13978884
106megakaryocyte development (GO:0035855)3.13848780
107T cell costimulation (GO:0031295)3.13645053
108B cell receptor signaling pathway (GO:0050853)3.13111008
109negative regulation of lymphocyte mediated immunity (GO:0002707)3.12857175
110T-helper cell differentiation (GO:0042093)3.12135463
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.12135463
112T cell homeostasis (GO:0043029)3.10674775
113regulation of regulatory T cell differentiation (GO:0045589)3.10397008
114defense response to protozoan (GO:0042832)3.10156331
115alpha-beta T cell activation (GO:0046631)3.10114262
116lymphocyte costimulation (GO:0031294)3.09507844
117negative regulation of adaptive immune response (GO:0002820)3.07264719
118regulation of T cell receptor signaling pathway (GO:0050856)3.07187091
119antigen receptor-mediated signaling pathway (GO:0050851)3.07150010
120myeloid dendritic cell activation (GO:0001773)3.06916073
121positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05999951
122alpha-beta T cell differentiation involved in immune response (GO:0002293)3.05794732
123alpha-beta T cell activation involved in immune response (GO:0002287)3.05794732
124T cell differentiation involved in immune response (GO:0002292)3.05794732
125negative regulation of phagocytosis (GO:0050765)3.04451071
126regulation of alpha-beta T cell proliferation (GO:0046640)3.04380202
127regulation of response to interferon-gamma (GO:0060330)3.03887994
128regulation of isotype switching (GO:0045191)3.02392977
129regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.01655128
130positive regulation of macrophage differentiation (GO:0045651)3.00988624
131positive regulation of immunoglobulin production (GO:0002639)2.99826505
132response to protozoan (GO:0001562)2.99274768
133negative regulation of type 2 immune response (GO:0002829)2.99183255
134negative regulation of innate immune response (GO:0045824)2.99174576
135regulation of mast cell degranulation (GO:0043304)2.98646308
136regulation of tolerance induction (GO:0002643)2.97934021
137regulation of T cell tolerance induction (GO:0002664)2.97871683
138response to interferon-alpha (GO:0035455)2.97311018
139positive regulation of B cell differentiation (GO:0045579)2.96823200
140positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95847569
141negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95620214
142positive regulation of interferon-gamma production (GO:0032729)2.94624619
143regulation of B cell mediated immunity (GO:0002712)2.94134766
144regulation of lymphocyte mediated immunity (GO:0002706)2.93559844
145positive regulation of interferon-alpha production (GO:0032727)2.93558691
146interferon-gamma-mediated signaling pathway (GO:0060333)2.92897992
147regulation of immunoglobulin mediated immune response (GO:0002889)2.92535995
148mast cell activation involved in immune response (GO:0002279)2.92399531
149mast cell degranulation (GO:0043303)2.92399531
150hepatocyte apoptotic process (GO:0097284)2.91924581
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91903629
152regulation of interleukin-12 biosynthetic process (GO:0045075)2.91483167
153regulation of T cell mediated cytotoxicity (GO:0001914)2.90245825
154T cell differentiation (GO:0030217)2.88539262
155alpha-beta T cell differentiation (GO:0046632)2.88194673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.77126782
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.63235743
3E2F7_22180533_ChIP-Seq_HELA_Human4.48330948
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.00284850
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87889279
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.86019358
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.78601471
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73815254
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.47782324
10* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.39141396
11RUNX_20019798_ChIP-Seq_JUKART_Human3.34828597
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.07145450
13MYB_26560356_Chip-Seq_TH2_Human3.04334351
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.93907007
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92430378
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.87969961
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83392518
18SCL_19346495_ChIP-Seq_HPC-7_Human2.78638316
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71096673
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.71030468
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.69923491
22MYB_26560356_Chip-Seq_TH1_Human2.61611972
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55794246
24MAF_26560356_Chip-Seq_TH1_Human2.54779185
25MYC_22102868_ChIP-Seq_BL_Human2.48404441
26* SPI1_23547873_ChIP-Seq_NB4_Human2.41472111
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39671450
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.22621883
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18763665
30UTX_26944678_Chip-Seq_JUKART_Human2.16521677
31VDR_21846776_ChIP-Seq_THP-1_Human2.16002962
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12737786
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08862487
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.99724663
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96710844
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95599437
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83455450
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81070564
39GATA3_27048872_Chip-Seq_THYMUS_Human1.80108771
40VDR_24763502_ChIP-Seq_THP-1_Human1.78138861
41TCF7_22412390_ChIP-Seq_EML_Mouse1.75307943
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69423785
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.66627050
44SPI1_23127762_ChIP-Seq_K562_Human1.62972278
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62411051
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.62046223
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60845214
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59088052
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54470948
50* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53385817
51PU_27001747_Chip-Seq_BMDM_Mouse1.53177838
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53028953
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52211485
54MAF_26560356_Chip-Seq_TH2_Human1.48759685
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47566828
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45015272
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44056651
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41170003
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37388762
60* GATA3_26560356_Chip-Seq_TH2_Human1.36122099
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33019708
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28255337
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25627064
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24493858
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21076119
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17216721
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16837016
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15981714
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14777091
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12400933
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11343766
72GATA1_22025678_ChIP-Seq_K562_Human1.09187053
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07858114
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06691122
75GATA1_19941826_ChIP-Seq_K562_Human1.04819918
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03543304
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.02375204
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01983142
79KDM2B_26808549_Chip-Seq_DND41_Human0.96265981
80VDR_23849224_ChIP-Seq_CD4+_Human0.94032194
81CIITA_25753668_ChIP-Seq_RAJI_Human0.93298918
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91594110
83VDR_24787735_ChIP-Seq_THP-1_Human0.91318026
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.91160618
85* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90335721
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90104286
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.86308624
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86039251
89ELK1_19687146_ChIP-ChIP_HELA_Human0.86016847
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85928818
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85656915
92NCOR1_26117541_ChIP-Seq_K562_Human0.84442465
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84208013
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83357279
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81382522
96FOXP3_21729870_ChIP-Seq_TREG_Human0.81140979
97BCL6_27268052_Chip-Seq_Bcells_Human0.81050507
98SMRT_27268052_Chip-Seq_Bcells_Human0.80067884
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.79687766
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79299599
101* GATA2_19941826_ChIP-Seq_K562_Human0.79039174
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.77945182
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77783783
104RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76605273
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76268653
106* GATA3_26560356_Chip-Seq_TH1_Human0.75358015
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75077334
108RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74661882
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.74436500
110GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74312637
111PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74248808
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74035436
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73019708
114SPI1_20517297_ChIP-Seq_HL60_Human0.72266086
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72002634
116EGR1_19032775_ChIP-ChIP_M12_Human0.69767931
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69703894
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.64415406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.72104568
2MP0009785_altered_susceptibility_to3.68024556
3MP0001835_abnormal_antigen_presentation3.58946049
4MP0003763_abnormal_thymus_physiology3.36812911
5MP0003436_decreased_susceptibility_to3.12723548
6MP0006082_CNS_inflammation3.12207545
7MP0000685_abnormal_immune_system3.10292054
8MP0001800_abnormal_humoral_immune3.09987535
9MP0005025_abnormal_response_to2.92926080
10* MP0002420_abnormal_adaptive_immunity2.88593117
11MP0005000_abnormal_immune_tolerance2.88557782
12MP0002396_abnormal_hematopoietic_system2.86553994
13* MP0001819_abnormal_immune_cell2.86136799
14* MP0002723_abnormal_immune_serum2.80204879
15MP0005387_immune_system_phenotype2.72503566
16MP0001790_abnormal_immune_system2.72503566
17MP0002452_abnormal_antigen_presenting2.70321519
18MP0002398_abnormal_bone_marrow2.63113673
19MP0002419_abnormal_innate_immunity2.58714147
20MP0002148_abnormal_hypersensitivity_rea2.54318388
21MP0005464_abnormal_platelet_physiology2.35112843
22MP0002405_respiratory_system_inflammati2.34372164
23MP0000716_abnormal_immune_system2.32852650
24MP0003724_increased_susceptibility_to2.22595782
25MP0001873_stomach_inflammation2.21386313
26MP0009333_abnormal_splenocyte_physiolog2.21086903
27MP0000858_altered_metastatic_potential2.11645630
28MP0010155_abnormal_intestine_physiology2.10303546
29MP0002006_tumorigenesis2.09233460
30MP0002722_abnormal_immune_system2.09042271
31MP0003448_altered_tumor_morphology2.06666115
32MP0002166_altered_tumor_susceptibility2.05674058
33MP0004808_abnormal_hematopoietic_stem2.00169779
34MP0000689_abnormal_spleen_morphology1.99709032
35MP0000703_abnormal_thymus_morphology1.96761338
36MP0002429_abnormal_blood_cell1.94458440
37MP0001845_abnormal_inflammatory_respons1.88102911
38MP0005397_hematopoietic_system_phenotyp1.82386392
39MP0001545_abnormal_hematopoietic_system1.82386392
40MP0009278_abnormal_bone_marrow1.80556964
41MP0002933_joint_inflammation1.80168570
42MP0002132_abnormal_respiratory_system1.74991982
43MP0004947_skin_inflammation1.73131464
44MP0001853_heart_inflammation1.71745914
45MP0003300_gastrointestinal_ulcer1.67368581
46MP0008260_abnormal_autophagy1.66968305
47MP0003303_peritoneal_inflammation1.62664598
48MP0003866_abnormal_defecation1.60199770
49MP0003191_abnormal_cellular_cholesterol1.54268214
50MP0000490_abnormal_crypts_of1.54168869
51MP0001533_abnormal_skeleton_physiology1.52896161
52MP0000465_gastrointestinal_hemorrhage1.51622185
53MP0005174_abnormal_tail_pigmentation1.40435687
54MP0008469_abnormal_protein_level1.36273036
55MP0004883_abnormal_blood_vessel1.29033493
56MP0010307_abnormal_tumor_latency1.27581161
57MP0003183_abnormal_peptide_metabolism1.23590899
58MP0005451_abnormal_body_composition1.22613057
59MP0002019_abnormal_tumor_incidence1.15647018
60MP0000343_altered_response_to1.15626957
61MP0005310_abnormal_salivary_gland1.11839165
62MP0001851_eye_inflammation1.11277960
63MP0000569_abnormal_digit_pigmentation1.06815862
64MP0009764_decreased_sensitivity_to1.04520361
65MP0003075_altered_response_to1.03428387
66MP0003690_abnormal_glial_cell1.03199099
67MP0005164_abnormal_response_to1.00693846
68MP0000015_abnormal_ear_pigmentation0.93867520
69MP0010352_gastrointestinal_tract_polyps0.93454784
70MP0002998_abnormal_bone_remodeling0.92151721
71MP0003172_abnormal_lysosome_physiology0.91261763
72MP0009763_increased_sensitivity_to0.87826875
73MP0005075_abnormal_melanosome_morpholog0.83425635
74MP0003566_abnormal_cell_adhesion0.83372375
75MP0004510_myositis0.82760183
76MP0002009_preneoplasia0.80824404
77MP0002095_abnormal_skin_pigmentation0.80473088
78MP0003656_abnormal_erythrocyte_physiolo0.80335619
79MP0005166_decreased_susceptibility_to0.80006395
80MP0008007_abnormal_cellular_replicative0.76989520
81MP0000604_amyloidosis0.74779227
82MP0003693_abnormal_embryo_hatching0.72917348
83MP0005023_abnormal_wound_healing0.72315295
84MP0004130_abnormal_muscle_cell0.71767604
85MP0002277_abnormal_respiratory_mucosa0.69616265
86MP0003045_fibrosis0.69297645
87MP0005390_skeleton_phenotype0.68698557
88MP0004484_altered_response_of0.63916687
89MP0002138_abnormal_hepatobiliary_system0.63886819
90MP0003221_abnormal_cardiomyocyte_apopto0.62151363
91MP0003795_abnormal_bone_structure0.61716841
92MP0003077_abnormal_cell_cycle0.60781568
93MP0003943_abnormal_hepatobiliary_system0.60753533
94MP0002877_abnormal_melanocyte_morpholog0.60335120
95MP0010094_abnormal_chromosome_stability0.59951760
96MP0002332_abnormal_exercise_endurance0.58084384
97MP0008057_abnormal_DNA_replication0.57753640
98MP0002693_abnormal_pancreas_physiology0.53945834
99MP0008874_decreased_physiological_sensi0.53352689
100MP0001191_abnormal_skin_condition0.52669428
101MP0000371_diluted_coat_color0.51856521
102MP0001663_abnormal_digestive_system0.51728444
103MP0003828_pulmonary_edema0.51309720
104MP0009765_abnormal_xenobiotic_induced0.51101967
105MP0005076_abnormal_cell_differentiation0.50948365
106MP0005319_abnormal_enzyme/_coenzyme0.50869193
107MP0001986_abnormal_taste_sensitivity0.50099361
108MP0003091_abnormal_cell_migration0.49736970
109MP0000249_abnormal_blood_vessel0.49399126
110MP0008058_abnormal_DNA_repair0.48905418
111MP0000477_abnormal_intestine_morphology0.48889285
112MP0003453_abnormal_keratinocyte_physiol0.48749252
113MP0008873_increased_physiological_sensi0.48346173
114MP0003279_aneurysm0.48070181
115MP0000609_abnormal_liver_physiology0.47139359
116MP0001243_abnormal_dermal_layer0.46745554
117MP0008004_abnormal_stomach_pH0.45615988
118MP0004381_abnormal_hair_follicle0.45316631
119MP0004264_abnormal_extraembryonic_tissu0.44336547
120MP0005388_respiratory_system_phenotype0.43349437
121MP0002133_abnormal_respiratory_system0.43349437

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)6.19570643
2Optic neuritis (HP:0100653)5.55997723
3Retrobulbar optic neuritis (HP:0100654)5.55997723
4Orchitis (HP:0100796)5.21761101
5Recurrent abscess formation (HP:0002722)5.10405830
6Eczematoid dermatitis (HP:0000976)4.96689419
7T lymphocytopenia (HP:0005403)4.65380183
8Abnormality of T cell number (HP:0011839)4.58019819
9Elevated erythrocyte sedimentation rate (HP:0003565)4.28302743
10IgM deficiency (HP:0002850)4.24641283
11Recurrent fungal infections (HP:0002841)4.14387414
12Recurrent bacterial skin infections (HP:0005406)4.10045885
13Encephalitis (HP:0002383)4.04973337
14Meningitis (HP:0001287)3.91411079
15Nasal polyposis (HP:0100582)3.88449966
16Abnormality of T cells (HP:0002843)3.84706697
17Keratoconjunctivitis sicca (HP:0001097)3.82490266
18Abnormality of macrophages (HP:0004311)3.66955187
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.62532753
20Obstructive lung disease (HP:0006536)3.52696629
21Chronic obstructive pulmonary disease (HP:0006510)3.52696629
22Recurrent viral infections (HP:0004429)3.47807418
23Keratoconjunctivitis (HP:0001096)3.45652182
24Abnormality of the nasal mucosa (HP:0000433)3.43906347
25Prolonged bleeding time (HP:0003010)3.42364116
26Stomatitis (HP:0010280)3.40455658
27Mediastinal lymphadenopathy (HP:0100721)3.39285138
28Spontaneous hematomas (HP:0007420)3.37846232
29Recurrent gram-negative bacterial infections (HP:0005420)3.37185694
30Arterial thrombosis (HP:0004420)3.37019689
31Vasculitis (HP:0002633)3.29040705
32Chronic otitis media (HP:0000389)3.27197924
33Pustule (HP:0200039)3.25831117
34Hypochromic microcytic anemia (HP:0004840)3.24831569
35Abnormality of T cell physiology (HP:0011840)3.08035588
36Recurrent bronchitis (HP:0002837)3.07899131
37Episodic fever (HP:0001954)3.04504824
38Chronic mucocutaneous candidiasis (HP:0002728)3.03000087
39Recurrent cutaneous fungal infections (HP:0011370)3.03000087
40Hypochromic anemia (HP:0001931)3.00128262
41Hemoptysis (HP:0002105)2.98771211
42Pulmonary infiltrates (HP:0002113)2.98483470
43Recurrent skin infections (HP:0001581)2.96532519
44Panhypogammaglobulinemia (HP:0003139)2.94840437
45Epistaxis (HP:0000421)2.87720997
46Joint swelling (HP:0001386)2.86623582
47Severe combined immunodeficiency (HP:0004430)2.86579832
48Thrombocytosis (HP:0001894)2.83583004
49Leukocytosis (HP:0001974)2.83218917
50Petechiae (HP:0000967)2.81411963
51Peritonitis (HP:0002586)2.80930137
52Thyroiditis (HP:0100646)2.75284746
53IgG deficiency (HP:0004315)2.72898303
54B lymphocytopenia (HP:0010976)2.71430099
55Abnormality of B cell number (HP:0010975)2.71430099
56Inflammation of the large intestine (HP:0002037)2.69932804
57Autoimmune thrombocytopenia (HP:0001973)2.69104205
58Increased IgE level (HP:0003212)2.68425176
59Combined immunodeficiency (HP:0005387)2.68155718
60Lymphopenia (HP:0001888)2.65992256
61Gingival bleeding (HP:0000225)2.62485148
62Eosinophilia (HP:0001880)2.62426799
63Gingivitis (HP:0000230)2.61808279
64Abnormality of eosinophils (HP:0001879)2.61727427
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.57499472
66Hypoproteinemia (HP:0003075)2.56154912
67Abnormality of the fingertips (HP:0001211)2.55978655
68Gastrointestinal inflammation (HP:0004386)2.54796470
69Pulmonary embolism (HP:0002204)2.52470763
70Periodontitis (HP:0000704)2.52103322
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50453261
72Osteomyelitis (HP:0002754)2.43955090
73Lymphoma (HP:0002665)2.43015443
74Chronic diarrhea (HP:0002028)2.39441374
75Abnormal platelet volume (HP:0011876)2.38982002
76Abnormality of the prostate (HP:0008775)2.34809384
77Abnormal platelet function (HP:0011869)2.31507217
78Impaired platelet aggregation (HP:0003540)2.31507217
79Granulocytopenia (HP:0001913)2.29761797
80Keratitis (HP:0000491)2.28035108
81Cellulitis (HP:0100658)2.27612418
82Increased IgM level (HP:0003496)2.23802293
83Microcytic anemia (HP:0001935)2.21407310
84Chest pain (HP:0100749)2.20783788
85Glomerulopathy (HP:0100820)2.20095521
86Sepsis (HP:0100806)2.18637081
87Acute myeloid leukemia (HP:0004808)2.18247417
88Stomach cancer (HP:0012126)2.16650499
89Anorexia (HP:0002039)2.15315732
90Premature loss of primary teeth (HP:0006323)2.13203658
91Gangrene (HP:0100758)2.12925150
92Hypergammaglobulinemia (HP:0010702)2.11997715
93IgA deficiency (HP:0002720)2.07473813
94Abnormality of the peritoneum (HP:0002585)2.06548297
95Acne (HP:0001061)2.03877256
96Urticaria (HP:0001025)2.03422511
97Skin ulcer (HP:0200042)2.02006311
98Vertigo (HP:0002321)2.01473968
99Menorrhagia (HP:0000132)2.01362419
100Abnormality of the pleura (HP:0002103)2.00669757
101Subacute progressive viral hepatitis (HP:0006572)2.00247500
102Cheilitis (HP:0100825)2.00221305
103Autoimmune hemolytic anemia (HP:0001890)2.00095076
104Colitis (HP:0002583)1.99388347
105Myelodysplasia (HP:0002863)1.99099133
106Interstitial pulmonary disease (HP:0006530)1.98808792
107Gastrointestinal infarctions (HP:0005244)1.96467618
108Spinal cord lesions (HP:0100561)1.96027643
109Syringomyelia (HP:0003396)1.96027643
110Skin rash (HP:0000988)1.94421236
111Acute hepatic failure (HP:0006554)1.94207462
112Slow saccadic eye movements (HP:0000514)1.94030956
113Recurrent sinusitis (HP:0011108)1.93021880
114Hemiplegia (HP:0002301)1.92334359
115Polyneuropathy (HP:0001271)1.90162272
116Abnormality of the endocardium (HP:0004306)1.88945764
117Absent frontal sinuses (HP:0002688)1.88782796
118Hematochezia (HP:0002573)1.88502587
119Abnormality of the pericardium (HP:0001697)1.88388645
120Papilledema (HP:0001085)1.87753018
121Abnormality of iron homeostasis (HP:0011031)1.87411564
122Amaurosis fugax (HP:0100576)1.86479270
123Increased density of long bones (HP:0006392)1.85763169
124Viral hepatitis (HP:0006562)1.82672207
125Verrucae (HP:0200043)1.80593849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.20469993
2MAP4K14.22052356
3ITK3.18914913
4JAK33.14220553
5TEC2.53480479
6BTK2.47263363
7IRAK42.46266953
8STK102.44338069
9ZAP702.32105231
10MAP3K142.30121190
11JAK12.28246008
12TYK22.04086104
13CSK2.02458111
14KIT1.88941746
15TBK11.79154035
16TGFBR21.76392279
17GRK61.73218384
18IKBKE1.70513820
19FES1.67718089
20ERN11.65263828
21LCK1.63615201
22PRPF4B1.62365901
23BLK1.55379636
24MATK1.50115318
25FLT31.50032636
26TAOK31.48059677
27SYK1.47589080
28HCK1.46544219
29IRAK31.45027883
30GRK71.40136300
31PIM11.37995836
32CSF1R1.37711262
33NUAK11.36897485
34EPHB11.36592558
35FGFR31.36489899
36MAP2K31.30492567
37MAP3K121.28265302
38IRAK11.28013810
39CLK11.21242681
40TRPM71.17142995
41IKBKB1.15382764
42ADRBK21.14283694
43MARK31.12504797
44TNK21.09201920
45RIPK11.08111478
46KSR21.04687581
47LYN1.01504251
48MAP3K11.01391634
49FGFR41.00191510
50RPS6KA40.98476800
51MAP3K60.96891057
52EEF2K0.94482157
53LRRK20.93981124
54MAP2K20.93556464
55PTK2B0.91251281
56SIK20.90988812
57PRKCQ0.90858629
58PIK3CG0.87799164
59BMPR20.86438409
60TTN0.85124040
61MAP2K60.81701907
62STK240.81105913
63NLK0.78790115
64SIK30.78624825
65PRKCH0.77460659
66MAP3K130.77090374
67CHUK0.75764983
68PRKD20.72354773
69MAP3K20.72193152
70JAK20.71451707
71NEK20.70402415
72CDK90.68798863
73MARK20.68786443
74MST40.67913698
75CDK40.67599913
76MAPK70.67215886
77STK40.66990918
78PTK60.66972771
79RIPK40.64966211
80MAP3K50.63155664
81FYN0.61840572
82BRSK20.60349580
83ACVR1B0.59650545
84PRKG20.59572680
85PKN20.58146332
86DMPK0.57998609
87IRAK20.57814401
88NEK90.56477693
89RET0.55268371
90SGK30.54922237
91CAMKK20.54762789
92KDR0.53488637
93EPHA30.53416060
94MAPK120.53121910
95MAP3K100.50262585
96PDPK10.49421965
97NME20.48101297
98GRK50.47926421
99STK110.47803203
100CDC42BPA0.44745901
101SGK20.44374279
102MAPKAPK20.43614989
103ALK0.43170768
104MAP3K30.42901755
105FGR0.42445297
106MAP2K40.42442002
107TGFBR10.41259696
108MELK0.41238404
109CDK120.41022173
110TRIB30.40830433
111MAPK40.40731203
112RAF10.40578638
113STK380.39856028
114ATR0.38638382
115KSR10.38197016
116MAP3K70.38169967
117EIF2AK20.38022458
118DYRK1B0.36621421
119MKNK20.36397370
120CDK60.35833434
121MAP3K110.34977373
122RPS6KC10.34973962
123RPS6KL10.34973962
124PIM20.34509266
125RPS6KA60.34475304
126HIPK20.33888604
127IGF1R0.33427163
128TAOK10.32065873
129PDK10.31870518
130TESK20.31842659
131MAPK110.31182711
132WNK10.29656112
133PASK0.29409875
134CAMKK10.29281243
135TAOK20.29211459
136PDGFRB0.28072761
137CDK80.27763164
138YES10.26385109
139PRKCD0.26076155
140DAPK20.24726296

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.71396973
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.44489712
3Allograft rejection_Homo sapiens_hsa053303.21548999
4Primary immunodeficiency_Homo sapiens_hsa053403.11994865
5* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.96586094
6Leishmaniasis_Homo sapiens_hsa051402.68689705
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.39696621
8Antigen processing and presentation_Homo sapiens_hsa046122.36425112
9Measles_Homo sapiens_hsa051622.31789121
10Autoimmune thyroid disease_Homo sapiens_hsa053202.19377040
11T cell receptor signaling pathway_Homo sapiens_hsa046602.17570631
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.14236416
13Osteoclast differentiation_Homo sapiens_hsa043801.95560339
14Hematopoietic cell lineage_Homo sapiens_hsa046401.95076233
15Viral myocarditis_Homo sapiens_hsa054161.91202723
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.78505774
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74198959
18Type I diabetes mellitus_Homo sapiens_hsa049401.73611737
19B cell receptor signaling pathway_Homo sapiens_hsa046621.72026454
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65925721
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.60959557
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60430779
23Herpes simplex infection_Homo sapiens_hsa051681.50205134
24Staphylococcus aureus infection_Homo sapiens_hsa051501.49723901
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49498696
26Malaria_Homo sapiens_hsa051441.48076250
27TNF signaling pathway_Homo sapiens_hsa046681.43308782
28Chemokine signaling pathway_Homo sapiens_hsa040621.39941427
29Shigellosis_Homo sapiens_hsa051311.38671064
30Toxoplasmosis_Homo sapiens_hsa051451.37831046
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37710154
32* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30894908
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28773725
34Influenza A_Homo sapiens_hsa051641.25664176
35Asthma_Homo sapiens_hsa053101.23817336
36Legionellosis_Homo sapiens_hsa051341.22677668
37Hepatitis B_Homo sapiens_hsa051611.22144983
38Apoptosis_Homo sapiens_hsa042101.20716414
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20658241
40Pertussis_Homo sapiens_hsa051331.10683928
41Acute myeloid leukemia_Homo sapiens_hsa052211.08329001
42Tuberculosis_Homo sapiens_hsa051521.07456455
43Platelet activation_Homo sapiens_hsa046111.05599084
44Pancreatic cancer_Homo sapiens_hsa052121.01835359
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98725973
46Non-homologous end-joining_Homo sapiens_hsa034500.91030768
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89928680
48Epstein-Barr virus infection_Homo sapiens_hsa051690.88671422
49HTLV-I infection_Homo sapiens_hsa051660.88506613
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87992201
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86582996
52Chronic myeloid leukemia_Homo sapiens_hsa052200.86237644
53Rheumatoid arthritis_Homo sapiens_hsa053230.80698600
54DNA replication_Homo sapiens_hsa030300.80349873
55Salmonella infection_Homo sapiens_hsa051320.80255299
56p53 signaling pathway_Homo sapiens_hsa041150.73986398
57Hepatitis C_Homo sapiens_hsa051600.73773916
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73125843
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70389717
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69083995
61Renal cell carcinoma_Homo sapiens_hsa052110.67971989
62Viral carcinogenesis_Homo sapiens_hsa052030.67359784
63Colorectal cancer_Homo sapiens_hsa052100.67261486
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65802295
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64314898
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.64204893
67Dorso-ventral axis formation_Homo sapiens_hsa043200.63494552
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62613032
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60599912
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.60453842
71Base excision repair_Homo sapiens_hsa034100.60438620
72Regulation of autophagy_Homo sapiens_hsa041400.59973289
73Mismatch repair_Homo sapiens_hsa034300.58939293
74Other glycan degradation_Homo sapiens_hsa005110.58073384
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57915537
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57654519
77Small cell lung cancer_Homo sapiens_hsa052220.56420430
78VEGF signaling pathway_Homo sapiens_hsa043700.56263547
79Prolactin signaling pathway_Homo sapiens_hsa049170.54187446
80Non-small cell lung cancer_Homo sapiens_hsa052230.54002687
81Choline metabolism in cancer_Homo sapiens_hsa052310.53854755
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.52643900
83Homologous recombination_Homo sapiens_hsa034400.50481639
84Cell cycle_Homo sapiens_hsa041100.49988572
85mTOR signaling pathway_Homo sapiens_hsa041500.49812611
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48778776
87FoxO signaling pathway_Homo sapiens_hsa040680.47546677
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47176584
89RNA degradation_Homo sapiens_hsa030180.45103432
90GnRH signaling pathway_Homo sapiens_hsa049120.44813548
91Endometrial cancer_Homo sapiens_hsa052130.44779418
92Type II diabetes mellitus_Homo sapiens_hsa049300.39806189
93Fanconi anemia pathway_Homo sapiens_hsa034600.39254126
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38650161
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.38207752
96Endocytosis_Homo sapiens_hsa041440.37240287
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.35336292
98Rap1 signaling pathway_Homo sapiens_hsa040150.34208905
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33693145
100Phagosome_Homo sapiens_hsa041450.31570997
101African trypanosomiasis_Homo sapiens_hsa051430.30859093
102MAPK signaling pathway_Homo sapiens_hsa040100.29692071
103Focal adhesion_Homo sapiens_hsa045100.29167476
104Prostate cancer_Homo sapiens_hsa052150.28769807
105Insulin resistance_Homo sapiens_hsa049310.28560072
106ErbB signaling pathway_Homo sapiens_hsa040120.27904559
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.27492079
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27374453
109Estrogen signaling pathway_Homo sapiens_hsa049150.26467497
110Ras signaling pathway_Homo sapiens_hsa040140.25714376
111Pathways in cancer_Homo sapiens_hsa052000.25657120
112Inositol phosphate metabolism_Homo sapiens_hsa005620.25501494
113Amoebiasis_Homo sapiens_hsa051460.24824123
114HIF-1 signaling pathway_Homo sapiens_hsa040660.24371356
115Spliceosome_Homo sapiens_hsa030400.24122321
116MicroRNAs in cancer_Homo sapiens_hsa052060.22441551
117Notch signaling pathway_Homo sapiens_hsa043300.20892579
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20072259
119Nucleotide excision repair_Homo sapiens_hsa034200.19391022
120Proteoglycans in cancer_Homo sapiens_hsa052050.19182955
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19070505
122Ribosome_Homo sapiens_hsa030100.17559196

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »