IL19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of heat generation (GO:0031652)7.31779078
2regulation of fever generation (GO:0031620)7.31686809
3positive regulation of chemokine biosynthetic process (GO:0045080)6.01722501
4cellular response to exogenous dsRNA (GO:0071360)5.97388262
5regulation of chronic inflammatory response (GO:0002676)5.88087778
6regulation of heat generation (GO:0031650)5.64097827
7positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.55085656
8regulation of T cell cytokine production (GO:0002724)5.52266913
9regulation of cytokine secretion involved in immune response (GO:0002739)5.41505471
10lipopolysaccharide-mediated signaling pathway (GO:0031663)5.19638760
11regulation of chemokine biosynthetic process (GO:0045073)5.14444539
12regulation of podosome assembly (GO:0071801)5.07275489
13positive regulation of toll-like receptor signaling pathway (GO:0034123)5.02239247
14regulation of T-helper 1 cell differentiation (GO:0045625)4.88023179
15positive regulation of type 2 immune response (GO:0002830)4.78814443
16respiratory burst (GO:0045730)4.77639994
17positive regulation of T cell cytokine production (GO:0002726)4.77382596
18positive regulation by symbiont of host defense response (GO:0052509)4.76879641
19modulation by symbiont of host defense response (GO:0052031)4.76879641
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.76879641
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.76879641
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.76879641
23modulation by symbiont of host immune response (GO:0052553)4.76879641
24leukocyte aggregation (GO:0070486)4.76596817
25cellular response to interferon-beta (GO:0035458)4.74636533
26regulation of vitamin D biosynthetic process (GO:0060556)4.61332574
27cellular response to ATP (GO:0071318)4.51309494
28negative regulation of interleukin-12 production (GO:0032695)4.42703813
29negative regulation of viral genome replication (GO:0045071)4.41552319
30microglial cell activation (GO:0001774)4.34748596
31regulation of vitamin metabolic process (GO:0030656)4.33344488
32regulation of heterotypic cell-cell adhesion (GO:0034114)4.29099179
33positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.27064114
34regulation of mononuclear cell migration (GO:0071675)4.24558519
35type I interferon signaling pathway (GO:0060337)4.23624150
36cellular response to type I interferon (GO:0071357)4.23624150
37response to type I interferon (GO:0034340)4.18751540
38regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.17657635
39positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.17657635
40lymphocyte chemotaxis (GO:0048247)4.07779108
41response to interferon-beta (GO:0035456)4.06967889
42regulation of histone phosphorylation (GO:0033127)4.03052609
43hydrogen peroxide biosynthetic process (GO:0050665)4.02249574
44positive regulation of interferon-alpha production (GO:0032727)4.01734211
45response to peptidoglycan (GO:0032494)3.87213788
46branching involved in labyrinthine layer morphogenesis (GO:0060670)3.86355706
47granulocyte activation (GO:0036230)3.85183038
48regulation of immunoglobulin secretion (GO:0051023)3.83845377
49regulation of interferon-alpha production (GO:0032647)3.83714573
50macrophage activation involved in immune response (GO:0002281)3.83449401
51regulation of type 2 immune response (GO:0002828)3.82597834
52positive regulation of defense response to virus by host (GO:0002230)3.80973098
53negative regulation of cytokine production involved in immune response (GO:0002719)3.79749209
54response to protozoan (GO:0001562)3.75474678
55regulation of nitric oxide biosynthetic process (GO:0045428)3.70136106
56positive regulation of lymphocyte migration (GO:2000403)3.67580590
57negative regulation of nitric oxide biosynthetic process (GO:0045019)3.66845479
58positive regulation of nitric oxide biosynthetic process (GO:0045429)3.65340962
59cellular response to nicotine (GO:0071316)3.63286078
60positive regulation of T-helper cell differentiation (GO:0045624)3.63091596
61response to manganese ion (GO:0010042)3.62883889
62negative regulation of T cell mediated immunity (GO:0002710)3.62699603
63sensory perception of smell (GO:0007608)3.61630805
64regulation of T-helper cell differentiation (GO:0045622)3.60652191
65macrophage activation (GO:0042116)3.58400365
66NIK/NF-kappaB signaling (GO:0038061)3.57405311
67monocyte chemotaxis (GO:0002548)3.57371993
68positive regulation of NF-kappaB import into nucleus (GO:0042346)3.56421730
69positive regulation vascular endothelial growth factor production (GO:0010575)3.55771740
70T-helper 1 type immune response (GO:0042088)3.55566854
71indole-containing compound catabolic process (GO:0042436)3.54289764
72indolalkylamine catabolic process (GO:0046218)3.54289764
73tryptophan catabolic process (GO:0006569)3.54289764
74neutrophil activation involved in immune response (GO:0002283)3.53934599
75positive regulation of acute inflammatory response (GO:0002675)3.51665675
76reactive oxygen species biosynthetic process (GO:1903409)3.50099547
77I-kappaB phosphorylation (GO:0007252)3.48908748
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46085760
79positive regulation of natural killer cell differentiation (GO:0032825)3.45459776
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41666890
81response to host immune response (GO:0052572)3.41666890
82regulation of vascular endothelial growth factor production (GO:0010574)3.39222713
83leukocyte degranulation (GO:0043299)3.37539719
84regulation of membrane protein ectodomain proteolysis (GO:0051043)3.35467324
85superoxide anion generation (GO:0042554)3.35389222
86negative regulation of amino acid transport (GO:0051956)3.33954434
87positive regulation of mast cell activation involved in immune response (GO:0033008)3.33371697
88positive regulation of mast cell degranulation (GO:0043306)3.33371697
89positive regulation of monocyte chemotaxis (GO:0090026)3.31740592
90regulation of NF-kappaB import into nucleus (GO:0042345)3.29136645
91negative regulation by host of viral transcription (GO:0043922)3.28946567
92regulation of interleukin-8 biosynthetic process (GO:0045414)3.28532645
93cellular response to interferon-alpha (GO:0035457)3.27779139
94kynurenine metabolic process (GO:0070189)3.27300682
95positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.26593131
96positive regulation of prostaglandin secretion (GO:0032308)3.26376705
97regulation of T cell mediated immunity (GO:0002709)3.24178244
98myeloid cell activation involved in immune response (GO:0002275)3.21756274
99natural killer cell activation involved in immune response (GO:0002323)3.19576771
100negative regulation of lipid storage (GO:0010888)3.19199004
101cellular response to virus (GO:0098586)3.18867918
102negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.18737889
103response to interferon-alpha (GO:0035455)3.15692286
104modulation of growth of symbiont involved in interaction with host (GO:0044144)3.13555648
105regulation of growth of symbiont in host (GO:0044126)3.13555648
106negative regulation of growth of symbiont in host (GO:0044130)3.13555648
107negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.13555648
108regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.13291063
109defense response to protozoan (GO:0042832)3.13181112
110cellular response to molecule of bacterial origin (GO:0071219)3.12914330
111negative regulation of type 2 immune response (GO:0002829)3.10304068
112positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.09872477
113positive regulation of chemokine production (GO:0032722)3.09139591
114regulation of prostaglandin secretion (GO:0032306)3.08452913
115regulation of interleukin-12 production (GO:0032655)3.08111050
116regulation of inflammatory response to antigenic stimulus (GO:0002861)3.07169906
117interferon-gamma-mediated signaling pathway (GO:0060333)3.06965655
118germinal center formation (GO:0002467)3.06305526
119myeloid dendritic cell differentiation (GO:0043011)3.05979686
120positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.05391535
121response to vitamin D (GO:0033280)3.05363710
122positive regulation of natural killer cell activation (GO:0032816)3.02631927
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02389795
124response to host (GO:0075136)3.02389795
125response to host defenses (GO:0052200)3.02389795
126regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.02204850
127negative regulation of production of molecular mediator of immune response (GO:0002701)3.01512807
128production of molecular mediator involved in inflammatory response (GO:0002532)3.01445621
129positive regulation of T cell mediated immunity (GO:0002711)3.00523691
130immunoglobulin mediated immune response (GO:0016064)3.00483953
131neutrophil chemotaxis (GO:0030593)3.00209434
132positive regulation of leukocyte degranulation (GO:0043302)2.99902514
133cellular response to ethanol (GO:0071361)2.99476612
134positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.99171180
135positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97141522
136inflammatory response to antigenic stimulus (GO:0002437)2.97023787
137ventricular system development (GO:0021591)2.96793623
138positive regulation of interferon-beta production (GO:0032728)2.96545595
139negative regulation of viral process (GO:0048525)2.96146588
140positive regulation of interleukin-6 production (GO:0032755)2.95223753
141positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.94445125
142regulation of interferon-beta biosynthetic process (GO:0045357)2.93804823
143regulation of lymphocyte migration (GO:2000401)2.91722855
144amine catabolic process (GO:0009310)2.91392381
145cellular biogenic amine catabolic process (GO:0042402)2.91392381
146neutrophil migration (GO:1990266)2.91216539
147regulation of defense response to virus by host (GO:0050691)2.90820922
148regulation of T-helper 2 cell differentiation (GO:0045628)2.89316361
149cellular response to lipopolysaccharide (GO:0071222)2.87892291
150regulation of natural killer cell activation (GO:0032814)2.86762218
151CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.86688966
152activation of MAPKKK activity (GO:0000185)2.86348106
153eosinophil chemotaxis (GO:0048245)2.85299252
154positive regulation of interleukin-12 production (GO:0032735)2.85093595
155negative regulation of cytokine secretion (GO:0050710)2.81990234
156regulation of interferon-gamma biosynthetic process (GO:0045072)2.81714928
157response to ATP (GO:0033198)2.80828085
158regulation of T cell tolerance induction (GO:0002664)2.80826944
159tryptophan metabolic process (GO:0006568)2.80116818
160positive regulation of transcription factor import into nucleus (GO:0042993)2.79614281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.38376687
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.00946151
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.82924312
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.32474414
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.82636569
6GATA1_22025678_ChIP-Seq_K562_Human3.77388638
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.56962010
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07160684
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.78001125
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70142872
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36006971
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30613408
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23924959
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.21521168
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12779349
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.09505162
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02753044
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90462114
19EGR1_19032775_ChIP-ChIP_M12_Human1.78116443
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63310119
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61121323
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59626034
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55711088
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55532871
25NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.55078701
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54468524
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52839540
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45516613
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42423623
30* GATA3_26560356_Chip-Seq_TH2_Human1.38817979
31RUNX_20019798_ChIP-Seq_JUKART_Human1.38302721
32JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38112851
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34851470
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34832076
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34627296
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33212100
37STAT1_20625510_ChIP-Seq_HELA_Human1.32409480
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31346516
39SOX2_20726797_ChIP-Seq_SW620_Human1.26830250
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23913076
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23397629
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23397629
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23317813
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20029282
45SMRT_27268052_Chip-Seq_Bcells_Human1.19692493
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17206780
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14904302
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14136913
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12929999
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12929823
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11706857
52VDR_24787735_ChIP-Seq_THP-1_Human1.10978437
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10475345
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.08279007
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.07089002
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.06903443
57TAF2_19829295_ChIP-Seq_ESCs_Human1.06496782
58CBP_20019798_ChIP-Seq_JUKART_Human1.06335671
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06335671
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06290304
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04561666
62SPI1_23127762_ChIP-Seq_K562_Human1.04009653
63GATA1_19941826_ChIP-Seq_K562_Human1.02524793
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01540083
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01428267
66ZNF274_21170338_ChIP-Seq_K562_Hela1.01114749
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00794875
68* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97680585
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97104650
70CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96893261
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96811271
72ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96436928
73BCL6_27268052_Chip-Seq_Bcells_Human0.96264910
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95884076
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.94792521
76* MYC_19829295_ChIP-Seq_ESCs_Human0.94610842
77* PU_27001747_Chip-Seq_BMDM_Mouse0.94480656
78GATA2_19941826_ChIP-Seq_K562_Human0.93979058
79* TP53_18474530_ChIP-ChIP_U2OS_Human0.93953888
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93751620
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93641555
82JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93596625
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91906940
84MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91312300
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90384209
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90201251
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89696877
88SPI1_23547873_ChIP-Seq_NB4_Human0.87891182
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.87381257
90RAC3_21632823_ChIP-Seq_H3396_Human0.87313357
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87271360
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87053639
93NANOG_19829295_ChIP-Seq_ESCs_Human0.86199956
94SOX2_19829295_ChIP-Seq_ESCs_Human0.86199956
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85948024
96BCOR_27268052_Chip-Seq_Bcells_Human0.85685542
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85254205
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.85082590
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84540814
100CJUN_26792858_Chip-Seq_BT549_Human0.84529988
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.84463066
102* SMAD4_21741376_ChIP-Seq_EPCs_Human0.84046828
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83750614
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83567962
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83113689
106EZH2_22144423_ChIP-Seq_EOC_Human0.83026639
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82980229
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82980229
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82888877
110EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82126379
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.81926947
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81608842
113CEBPB_22108803_ChIP-Seq_LS180_Human0.80878484
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80055546
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79417160
116* SMAD3_21741376_ChIP-Seq_EPCs_Human0.79262071
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78932958
118P300_27268052_Chip-Seq_Bcells_Human0.78674963
119GBX2_23144817_ChIP-Seq_PC3_Human0.78536225
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78364707
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78075030
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77893510
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.76847015
124* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76734741
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.76408559
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76042654
127EZH2_18974828_ChIP-Seq_MESCs_Mouse0.75811917
128RNF2_18974828_ChIP-Seq_MESCs_Mouse0.75811917
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75719900
130AR_25329375_ChIP-Seq_VCAP_Human0.75654508
131EGR1_19374776_ChIP-ChIP_THP-1_Human0.75442799
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75326370
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75239777
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75007038
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.74433291
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74235189
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.73693278
138DROSHA_22980978_ChIP-Seq_HELA_Human0.73295885
139RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72549780
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72103111
141GATA3_27048872_Chip-Seq_THYMUS_Human0.70751945
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70258519
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69812173
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.69336646
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68341344
146* PU1_27457419_Chip-Seq_LIVER_Mouse0.67115685
147* MYB_26560356_Chip-Seq_TH2_Human0.67092286
148VDR_24763502_ChIP-Seq_THP-1_Human0.66470399
149VDR_22108803_ChIP-Seq_LS180_Human0.66403335
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64910372
151* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64889383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.56521115
2MP0003724_increased_susceptibility_to4.79986764
3MP0003303_peritoneal_inflammation4.57430670
4MP0001984_abnormal_olfaction3.89077308
5MP0008004_abnormal_stomach_pH3.18042349
6MP0005257_abnormal_intraocular_pressure3.01552961
7MP0009840_abnormal_foam_cell2.92590268
8MP0002148_abnormal_hypersensitivity_rea2.91687109
9MP0009278_abnormal_bone_marrow2.79688699
10MP0009785_altered_susceptibility_to2.73245661
11MP0005000_abnormal_immune_tolerance2.73139872
12MP0003436_decreased_susceptibility_to2.72914606
13MP0005410_abnormal_fertilization2.65358588
14MP0002139_abnormal_hepatobiliary_system2.61552729
15MP0005167_abnormal_blood-brain_barrier2.61408377
16MP0003195_calcinosis2.57341258
17MP0004510_myositis2.45559049
18MP0005058_abnormal_lysosome_morphology2.39519152
19MP0002277_abnormal_respiratory_mucosa2.29941104
20MP0002419_abnormal_innate_immunity2.23908671
21MP0002254_reproductive_system_inflammat2.19477683
22MP0001533_abnormal_skeleton_physiology2.18819276
23MP0005451_abnormal_body_composition2.16822985
24MP0001835_abnormal_antigen_presentation2.14342124
25MP0005025_abnormal_response_to2.00389464
26MP0005164_abnormal_response_to1.98323225
27MP0009764_decreased_sensitivity_to1.98286419
28MP0002006_tumorigenesis1.91805033
29MP0010352_gastrointestinal_tract_polyps1.89208997
30MP0003075_altered_response_to1.84968595
31MP0004947_skin_inflammation1.79092647
32MP0002332_abnormal_exercise_endurance1.77867069
33MP0002723_abnormal_immune_serum1.76682210
34MP0003690_abnormal_glial_cell1.75490655
35MP0002452_abnormal_antigen_presenting1.73716545
36MP0003646_muscle_fatigue1.60034908
37MP0002138_abnormal_hepatobiliary_system1.59328452
38MP0001790_abnormal_immune_system1.59161388
39MP0005387_immune_system_phenotype1.59161388
40MP0008469_abnormal_protein_level1.57202499
41MP0003191_abnormal_cellular_cholesterol1.55512386
42MP0001800_abnormal_humoral_immune1.55232862
43MP0006054_spinal_hemorrhage1.54574170
44MP0005166_decreased_susceptibility_to1.50737582
45MP0001958_emphysema1.50647551
46MP0001853_heart_inflammation1.44337092
47MP0001819_abnormal_immune_cell1.37337088
48MP0005310_abnormal_salivary_gland1.37288368
49MP0002998_abnormal_bone_remodeling1.35017866
50MP0003806_abnormal_nucleotide_metabolis1.34808938
51MP0002420_abnormal_adaptive_immunity1.34383040
52MP0003448_altered_tumor_morphology1.32725454
53MP0001845_abnormal_inflammatory_respons1.31869389
54MP0005464_abnormal_platelet_physiology1.29196248
55MP0005360_urolithiasis1.28387116
56MP0003183_abnormal_peptide_metabolism1.24991542
57MP0000685_abnormal_immune_system1.24795765
58MP0000579_abnormal_nail_morphology1.22316610
59MP0010155_abnormal_intestine_physiology1.20947555
60MP0004858_abnormal_nervous_system1.20319918
61MP0010234_abnormal_vibrissa_follicle1.16692428
62MP0002736_abnormal_nociception_after1.15690994
63MP0005397_hematopoietic_system_phenotyp1.15024628
64MP0001545_abnormal_hematopoietic_system1.15024628
65MP0005535_abnormal_body_temperature1.14834736
66MP0003011_delayed_dark_adaptation1.14021369
67MP0003300_gastrointestinal_ulcer1.13775983
68MP0005390_skeleton_phenotype1.11600873
69MP0003705_abnormal_hypodermis_morpholog1.08834821
70MP0003453_abnormal_keratinocyte_physiol1.08026710
71MP0002928_abnormal_bile_duct1.07427140
72MP0000343_altered_response_to1.06805142
73MP0003045_fibrosis1.06179527
74MP0009333_abnormal_splenocyte_physiolog1.05751075
75MP0000604_amyloidosis1.04947187
76MP0005023_abnormal_wound_healing1.03475134
77MP0000858_altered_metastatic_potential0.99018760
78MP0004859_abnormal_synaptic_plasticity0.98721108
79MP0001663_abnormal_digestive_system0.97436763
80MP0001501_abnormal_sleep_pattern0.96403052
81MP0002877_abnormal_melanocyte_morpholog0.96252198
82MP0002653_abnormal_ependyma_morphology0.96019119
83MP0009763_increased_sensitivity_to0.94214354
84MP0005085_abnormal_gallbladder_physiolo0.93250482
85MP0003186_abnormal_redox_activity0.92976975
86MP0005671_abnormal_response_to0.90110490
87MP0010386_abnormal_urinary_bladder0.88519278
88MP0001881_abnormal_mammary_gland0.86793532
89MP0003172_abnormal_lysosome_physiology0.86146399
90MP0003252_abnormal_bile_duct0.84620977
91MP0002405_respiratory_system_inflammati0.83030744
92MP0001542_abnormal_bone_strength0.82626388
93MP0003950_abnormal_plasma_membrane0.82060115
94MP0000920_abnormal_myelination0.82048123
95MP0003091_abnormal_cell_migration0.81019751
96MP0000716_abnormal_immune_system0.80734056
97MP0004742_abnormal_vestibular_system0.80692007
98MP0004142_abnormal_muscle_tone0.80041756
99MP0002735_abnormal_chemical_nociception0.77829467
100MP0002837_dystrophic_cardiac_calcinosis0.77264747
101MP0002168_other_aberrant_phenotype0.77260444
102MP0005266_abnormal_metabolism0.75778788
103MP0003656_abnormal_erythrocyte_physiolo0.75525959
104MP0005448_abnormal_energy_balance0.74098594
105MP0000249_abnormal_blood_vessel0.71158038
106MP0002933_joint_inflammation0.67910738
107MP0000516_abnormal_urinary_system0.66296988
108MP0005367_renal/urinary_system_phenotyp0.66296988
109MP0003943_abnormal_hepatobiliary_system0.65915964
110MP0005379_endocrine/exocrine_gland_phen0.65737435
111MP0002429_abnormal_blood_cell0.65480925
112MP0005647_abnormal_sex_gland0.65275036
113MP0004043_abnormal_pH_regulation0.65037834
114MP0001727_abnormal_embryo_implantation0.63212051
115MP0003879_abnormal_hair_cell0.63141028
116MP0005595_abnormal_vascular_smooth0.62900721
117MP0005083_abnormal_biliary_tract0.62041525
118MP0005165_increased_susceptibility_to0.60617912
119MP0005381_digestive/alimentary_phenotyp0.59840562
120MP0003634_abnormal_glial_cell0.59322097
121MP0005187_abnormal_penis_morphology0.58857838
122MP0000371_diluted_coat_color0.58590867
123MP0002102_abnormal_ear_morphology0.58375414
124MP0002136_abnormal_kidney_physiology0.57885106
125MP0008873_increased_physiological_sensi0.56992386
126MP0009765_abnormal_xenobiotic_induced0.56653719
127MP0002398_abnormal_bone_marrow0.56424747
128MP0005084_abnormal_gallbladder_morpholo0.56401845
129MP0005319_abnormal_enzyme/_coenzyme0.56182319
130MP0001764_abnormal_homeostasis0.55897531
131MP0000230_abnormal_systemic_arterial0.55720034
132MP0008874_decreased_physiological_sensi0.55118260
133MP0003795_abnormal_bone_structure0.53633962
134MP0001968_abnormal_touch/_nociception0.53366455
135MP0004883_abnormal_blood_vessel0.52283923

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.66196416
2Abnormality of liposaccharide metabolism (HP:0010968)5.66196416
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.66196416
4Prostate neoplasm (HP:0100787)5.52064909
5Elevated erythrocyte sedimentation rate (HP:0003565)5.49575465
6Eczematoid dermatitis (HP:0000976)4.92632669
7Retrobulbar optic neuritis (HP:0100654)4.84901659
8Optic neuritis (HP:0100653)4.84901659
9Systemic lupus erythematosus (HP:0002725)4.82626959
10Stomatitis (HP:0010280)4.77789093
11Axonal loss (HP:0003447)4.57786306
12Basal ganglia calcification (HP:0002135)4.55100340
13Recurrent bacterial skin infections (HP:0005406)4.38352617
14Mediastinal lymphadenopathy (HP:0100721)4.27948052
15Recurrent abscess formation (HP:0002722)4.10723071
16Recurrent gram-negative bacterial infections (HP:0005420)4.01431620
17Vacuolated lymphocytes (HP:0001922)3.96305113
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.84650007
19Myositis (HP:0100614)3.77656767
20Nuclear cataract (HP:0100018)3.76118890
21Abnormality of macrophages (HP:0004311)3.68432921
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.62998487
23Vasculitis (HP:0002633)3.62914480
24Porencephaly (HP:0002132)3.60108400
25Severe visual impairment (HP:0001141)3.57765536
26Keratoconjunctivitis sicca (HP:0001097)3.53681879
27Autoimmune thrombocytopenia (HP:0001973)3.52947499
28Mutism (HP:0002300)3.47720185
29Loss of speech (HP:0002371)3.42786267
30Prolonged neonatal jaundice (HP:0006579)3.41614430
31Disinhibition (HP:0000734)3.40090281
32Keratoconjunctivitis (HP:0001096)3.25110360
33Generalized aminoaciduria (HP:0002909)3.11031196
34Gangrene (HP:0100758)3.10270459
35Urethral obstruction (HP:0000796)3.00629488
36Pulmonary artery stenosis (HP:0004415)2.98165271
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89610750
38Interstitial pulmonary disease (HP:0006530)2.86801703
39Neurofibrillary tangles (HP:0002185)2.76978557
40Fused cervical vertebrae (HP:0002949)2.74086460
41Pigmentary retinal degeneration (HP:0001146)2.71863804
42Abnormality of the prostate (HP:0008775)2.71041453
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.70438336
44Chronic otitis media (HP:0000389)2.64911121
45Prolonged bleeding time (HP:0003010)2.62230897
46Polyneuropathy (HP:0001271)2.61916929
47Chronic bronchitis (HP:0004469)2.55218755
48Tetraparesis (HP:0002273)2.54435438
49Joint swelling (HP:0001386)2.54200126
50Fatigue (HP:0012378)2.53862273
51Gastrointestinal stroma tumor (HP:0100723)2.53178283
52Bone pain (HP:0002653)2.52481713
53Asymmetric septal hypertrophy (HP:0001670)2.51863095
54Apathy (HP:0000741)2.48515506
55Parakeratosis (HP:0001036)2.47986598
56Nausea (HP:0002018)2.42945595
57Autoimmune hemolytic anemia (HP:0001890)2.42471279
58Amyloidosis (HP:0011034)2.40399613
59Pulmonary infiltrates (HP:0002113)2.39489241
60Glomerulonephritis (HP:0000099)2.39445667
61Short nail (HP:0001799)2.38666929
62Diminished motivation (HP:0000745)2.38524532
63Peritonitis (HP:0002586)2.35755106
64Esophageal neoplasm (HP:0100751)2.33935163
65Neoplasm of head and neck (HP:0012288)2.33935163
66Increased serum ferritin (HP:0003281)2.31767024
67Nephritis (HP:0000123)2.30089972
68Gingivitis (HP:0000230)2.30064377
69Thick nail (HP:0001805)2.28719540
70Leiomyosarcoma (HP:0100243)2.27771262
71Uterine leiomyosarcoma (HP:0002891)2.27771262
72Abnormality of the pericardium (HP:0001697)2.26609399
73Rhinitis (HP:0012384)2.26373994
74Pustule (HP:0200039)2.25437837
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24891122
76Metaphyseal irregularity (HP:0003025)2.24663309
77Recurrent skin infections (HP:0001581)2.21882566
78Abnormality of transition element cation homeostasis (HP:0011030)2.19796446
79Purpura (HP:0000979)2.19000776
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18959733
81Abnormality of polysaccharide metabolism (HP:0011012)2.18959733
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18959733
83Hemoptysis (HP:0002105)2.17961429
84Abnormality of the periventricular white matter (HP:0002518)2.17812485
85Mesangial abnormality (HP:0001966)2.16410750
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.15500789
87Absent/shortened dynein arms (HP:0200106)2.15500789
88Abnormality of the distal phalanges of the toes (HP:0010182)2.15350517
89Cleft eyelid (HP:0000625)2.15223723
90Premature loss of primary teeth (HP:0006323)2.14759214
91Hepatosplenomegaly (HP:0001433)2.13774713
92Increased cerebral lipofuscin (HP:0011813)2.13606022
93Recurrent viral infections (HP:0004429)2.13061479
94Renal Fanconi syndrome (HP:0001994)2.12245040
95Episodic fever (HP:0001954)2.12079015
96Vertigo (HP:0002321)2.11461077
97Nasal polyposis (HP:0100582)2.11324721
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10536805
99Gastrointestinal infarctions (HP:0005244)2.09941605
100Orchitis (HP:0100796)2.08204868
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.07752007
102Acrocyanosis (HP:0001063)2.06866335
103Increased neuronal autofluorescent lipopigment (HP:0002074)2.05909084
104Spastic tetraparesis (HP:0001285)2.05889830
105Portal hypertension (HP:0001409)2.04570797
106Lower limb hyperreflexia (HP:0002395)2.04278533
107Inappropriate behavior (HP:0000719)2.01791780
108Increased IgM level (HP:0003496)2.01687620
109Osteolytic defects of the hand bones (HP:0009699)2.01543382
110Osteolytic defects of the phalanges of the hand (HP:0009771)2.01543382
111Recurrent fungal infections (HP:0002841)2.01147047
112Dysostosis multiplex (HP:0000943)1.99534522
113Abnormality of the nasal mucosa (HP:0000433)1.98890839
114Arterial tortuosity (HP:0005116)1.97190706
115Vertebral compression fractures (HP:0002953)1.96961237
116Agnosia (HP:0010524)1.96733989
117Chronic hepatic failure (HP:0100626)1.96297174
118Abnormal rod and cone electroretinograms (HP:0008323)1.95777872
119Agitation (HP:0000713)1.95673737
120Abnormality of Sharpey fibers (HP:0100685)1.94830042
121Micronodular cirrhosis (HP:0001413)1.94244951
122Mucopolysacchariduria (HP:0008155)1.93922575
123Urinary glycosaminoglycan excretion (HP:0003541)1.93922575
124Muscle fiber splitting (HP:0003555)1.93247091
125Urticaria (HP:0001025)1.92788671
126Abnormality of iron homeostasis (HP:0011031)1.92280086
127Striae distensae (HP:0001065)1.92034060
128Abnormality of macular pigmentation (HP:0008002)1.91023514
129Chondrocalcinosis (HP:0000934)1.90997383
130Attenuation of retinal blood vessels (HP:0007843)1.90329504
131Arterial thrombosis (HP:0004420)1.90022746
132Male infertility (HP:0003251)1.89520410
133Increased IgE level (HP:0003212)1.88726487
134Petechiae (HP:0000967)1.88523118
135Hypergammaglobulinemia (HP:0010702)1.88502810
136Irregular vertebral endplates (HP:0003301)1.88423219
137Palpebral edema (HP:0100540)1.88414982
138Personality changes (HP:0000751)1.87384260
139Chronic obstructive pulmonary disease (HP:0006510)1.87367558
140Obstructive lung disease (HP:0006536)1.87367558
141Anorexia (HP:0002039)1.86752277
142Arthralgia (HP:0002829)1.86026838
143Keratitis (HP:0000491)1.85847471
144Abnormality of the costochondral junction (HP:0000919)1.84142978
145Abnormality of the hepatic vasculature (HP:0006707)1.83788616
146Hemorrhage of the eye (HP:0011885)1.83749528
147Abnormality of B cell number (HP:0010975)1.83166620
148Prolonged QT interval (HP:0001657)1.83149475
149Aplasia cutis congenita (HP:0001057)1.82838166
150Polydipsia (HP:0001959)1.82659135
151Abnormal drinking behavior (HP:0030082)1.82659135
152Poor head control (HP:0002421)1.82040890
153Exocrine pancreatic insufficiency (HP:0001738)1.81514459
154Opisthotonus (HP:0002179)1.80037590
155Emphysema (HP:0002097)1.78252029
156Amaurosis fugax (HP:0100576)1.77908658
157Recurrent pneumonia (HP:0006532)1.77684094
158Malnutrition (HP:0004395)1.77065017
159Progressive neurologic deterioration (HP:0002344)1.76767179
160Erythroderma (HP:0001019)1.75506852
161Absent frontal sinuses (HP:0002688)1.75460669
162Abnormality of purine metabolism (HP:0004352)1.74913326
163Periodontitis (HP:0000704)1.74773891
164Hyperextensible skin (HP:0000974)1.74646784
165Abnormality of the pleura (HP:0002103)1.74061238
166Plantar hyperkeratosis (HP:0007556)1.72592513
167Enlarged epiphyses (HP:0010580)1.71983744
168Palmoplantar hyperkeratosis (HP:0000972)1.71607201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.55348538
2ARAF4.50023234
3IRAK43.83741416
4CASK3.34686753
5MAP3K133.31159686
6MAP3K143.26453651
7RIPK43.07411018
8PIM22.85933750
9IRAK32.80337127
10MAP3K92.79600118
11TAOK22.75809853
12NME22.71821411
13TXK2.41642826
14TAOK12.35813803
15KSR22.33582977
16TYK22.13571810
17PLK42.08634978
18MAP3K112.05921363
19TBK12.03841629
20BRAF1.87717973
21CSK1.80905699
22STK38L1.79885876
23KIT1.74549021
24IRAK11.71711391
25IRAK21.66159398
26JAK11.64433916
27MAP3K21.64306321
28MAP3K121.51253065
29TGFBR21.47439608
30IKBKE1.46244779
31PKN11.45190475
32MAP3K51.43859049
33BLK1.42155470
34RIPK11.38770167
35FGR1.37293479
36TRIM281.35263005
37STK241.32217232
38MAP4K21.31747661
39ACVR1B1.30057838
40ERBB41.29622192
41GRK71.19919587
42ERBB31.19319146
43CDC42BPA1.17248870
44MATK1.06754839
45RAF11.05879975
46PIM11.03592418
47FRK0.99252345
48TYRO30.95917575
49NUAK10.94884341
50CCNB10.90496209
51MOS0.89540027
52BCKDK0.86947468
53LYN0.82849482
54PDK20.80500767
55HCK0.78974069
56EIF2AK20.76117093
57PLK20.76100468
58CAMKK20.75715826
59JAK30.75124373
60BMX0.74849085
61DYRK30.74637914
62STK100.73738075
63PIK3CG0.72857838
64FYN0.72532848
65JAK20.68679252
66MARK30.68358747
67STK30.65078993
68ADRBK20.64961372
69MAP3K30.64443101
70LATS10.63654131
71SIK20.62226233
72STK40.61941528
73BRD40.61885121
74IKBKB0.61540804
75DAPK30.60148743
76MAP2K60.59052647
77PRKD20.58190028
78ERN10.57209395
79RPS6KA40.56993364
80BMPR20.56396702
81GRK10.55953466
82CAMK1G0.55425781
83SYK0.55369692
84NTRK30.54791755
85ALK0.54764343
86CSNK1A1L0.53303166
87LATS20.50159358
88TRPM70.49723214
89MELK0.49374257
90DAPK20.48836399
91TESK10.46624916
92FES0.44432184
93LMTK20.43643537
94STK160.42641611
95MAP4K10.42211373
96CDK60.41297654
97NEK90.41258572
98PRKG20.41138991
99MUSK0.40811942
100PDK10.40000490
101INSRR0.39944842
102PAK30.39875113
103CAMK1D0.38836895
104MAP2K20.38608977
105MAP3K10.38535335
106PDPK10.38239769
107STK110.37938143
108LCK0.37587923
109PRKCQ0.37279859
110CSNK1G30.36861542
111EGFR0.36808113
112CSF1R0.36554383
113SIK30.36492516
114ABL20.36002293
115PRKCH0.34532456
116SGK10.34524062
117PKN20.34446202
118CSNK1G10.33852224
119MAPK40.33065934
120MAPK110.32044068
121TLK10.32025425
122CDK40.32007441
123DYRK1B0.31610138
124WNK10.30361523
125CHUK0.29782309
126DDR20.28769056
127PRKAA20.28005414
128PTK2B0.27895927
129CAMK2G0.27626819
130ABL10.26695400
131NLK0.26575874
132MAP2K10.26100709
133TAOK30.25789385
134ZAP700.25578461
135CLK10.25240036
136INSR0.24647138
137TNIK0.24576351
138STK380.23719767
139WNK30.21158378
140TESK20.19852999
141HIPK20.17511332
142BTK0.17262491

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.28495453
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.33992939
3Leishmaniasis_Homo sapiens_hsa051403.28639874
4Type I diabetes mellitus_Homo sapiens_hsa049403.20267748
5Olfactory transduction_Homo sapiens_hsa047403.07585509
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.90889066
7Staphylococcus aureus infection_Homo sapiens_hsa051502.69830975
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.41123709
9Pertussis_Homo sapiens_hsa051332.39714133
10African trypanosomiasis_Homo sapiens_hsa051432.35550422
11Legionellosis_Homo sapiens_hsa051342.26288710
12Prion diseases_Homo sapiens_hsa050202.24265678
13Malaria_Homo sapiens_hsa051442.21145666
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20211122
15Autoimmune thyroid disease_Homo sapiens_hsa053202.19692837
16Osteoclast differentiation_Homo sapiens_hsa043802.17634647
17Salmonella infection_Homo sapiens_hsa051322.13084002
18Influenza A_Homo sapiens_hsa051642.10949254
19NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09511989
20TNF signaling pathway_Homo sapiens_hsa046682.08044920
21Measles_Homo sapiens_hsa051621.94074781
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.89140158
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85851036
24Other glycan degradation_Homo sapiens_hsa005111.79088558
25Rheumatoid arthritis_Homo sapiens_hsa053231.75973011
26Tuberculosis_Homo sapiens_hsa051521.63760155
27Allograft rejection_Homo sapiens_hsa053301.53547982
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49404609
29Chemokine signaling pathway_Homo sapiens_hsa040621.38748008
30Dorso-ventral axis formation_Homo sapiens_hsa043201.36391324
31* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33018812
32Hematopoietic cell lineage_Homo sapiens_hsa046401.30980966
33Caffeine metabolism_Homo sapiens_hsa002321.28859138
34Asthma_Homo sapiens_hsa053101.25677455
35Herpes simplex infection_Homo sapiens_hsa051681.22715251
36Antigen processing and presentation_Homo sapiens_hsa046121.18039115
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15730779
38Toxoplasmosis_Homo sapiens_hsa051451.10748639
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.09210564
40Amoebiasis_Homo sapiens_hsa051461.09142232
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04391045
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03169497
43Hepatitis C_Homo sapiens_hsa051601.01889523
44* Jak-STAT signaling pathway_Homo sapiens_hsa046301.01607831
45Linoleic acid metabolism_Homo sapiens_hsa005911.00862860
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00700606
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99743689
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98660349
49Ether lipid metabolism_Homo sapiens_hsa005650.96086117
50Hepatitis B_Homo sapiens_hsa051610.94973831
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92907161
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92325396
53Platelet activation_Homo sapiens_hsa046110.83989980
54B cell receptor signaling pathway_Homo sapiens_hsa046620.76801498
55Collecting duct acid secretion_Homo sapiens_hsa049660.75766218
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.72210893
57Phagosome_Homo sapiens_hsa041450.72188133
58Ovarian steroidogenesis_Homo sapiens_hsa049130.70288350
59Mineral absorption_Homo sapiens_hsa049780.70134487
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.68888531
61Tryptophan metabolism_Homo sapiens_hsa003800.68881170
62Sulfur metabolism_Homo sapiens_hsa009200.67073772
63Epstein-Barr virus infection_Homo sapiens_hsa051690.65990373
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65976058
65VEGF signaling pathway_Homo sapiens_hsa043700.65044632
66Arginine biosynthesis_Homo sapiens_hsa002200.62119674
67Bladder cancer_Homo sapiens_hsa052190.57767463
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56934771
69Type II diabetes mellitus_Homo sapiens_hsa049300.53957893
70Primary immunodeficiency_Homo sapiens_hsa053400.50522821
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50058343
72Chronic myeloid leukemia_Homo sapiens_hsa052200.48232787
73Apoptosis_Homo sapiens_hsa042100.48163312
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47906333
75Lysosome_Homo sapiens_hsa041420.46782298
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45723870
77Shigellosis_Homo sapiens_hsa051310.44603653
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.43598789
79Renin-angiotensin system_Homo sapiens_hsa046140.43584790
80Notch signaling pathway_Homo sapiens_hsa043300.41924745
81Arachidonic acid metabolism_Homo sapiens_hsa005900.41666389
82Acute myeloid leukemia_Homo sapiens_hsa052210.39875873
83cAMP signaling pathway_Homo sapiens_hsa040240.39564265
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.39207717
85Galactose metabolism_Homo sapiens_hsa000520.39109262
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38840946
87Butanoate metabolism_Homo sapiens_hsa006500.38088272
88Complement and coagulation cascades_Homo sapiens_hsa046100.37981932
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37746226
90PPAR signaling pathway_Homo sapiens_hsa033200.36984183
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36695255
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35457831
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35007618
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34172265
95Small cell lung cancer_Homo sapiens_hsa052220.33424529
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31846799
97Cholinergic synapse_Homo sapiens_hsa047250.29345199
98Dilated cardiomyopathy_Homo sapiens_hsa054140.29235900
99Pancreatic cancer_Homo sapiens_hsa052120.29198591
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28519188
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.28498657
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28441715
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28367467
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.27303717
105Serotonergic synapse_Homo sapiens_hsa047260.26730730
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.25675170
107Systemic lupus erythematosus_Homo sapiens_hsa053220.25077348
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24733593
109T cell receptor signaling pathway_Homo sapiens_hsa046600.23825734
110ABC transporters_Homo sapiens_hsa020100.21602426
111Salivary secretion_Homo sapiens_hsa049700.21458297
112GnRH signaling pathway_Homo sapiens_hsa049120.21356428
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21329270
114Fatty acid biosynthesis_Homo sapiens_hsa000610.21021867
115Morphine addiction_Homo sapiens_hsa050320.20193997
116Sphingolipid metabolism_Homo sapiens_hsa006000.19914849
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19570603
118HIF-1 signaling pathway_Homo sapiens_hsa040660.19214953
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19035500
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18253584
121Melanogenesis_Homo sapiens_hsa049160.17843275
122Long-term depression_Homo sapiens_hsa047300.17769767
123Estrogen signaling pathway_Homo sapiens_hsa049150.17009121
124MAPK signaling pathway_Homo sapiens_hsa040100.16982429
125Phototransduction_Homo sapiens_hsa047440.16763173
126Viral myocarditis_Homo sapiens_hsa054160.16594445
127Gastric acid secretion_Homo sapiens_hsa049710.16305373
128Oxytocin signaling pathway_Homo sapiens_hsa049210.16254502
129Histidine metabolism_Homo sapiens_hsa003400.14804060
130ECM-receptor interaction_Homo sapiens_hsa045120.14725189
131Renal cell carcinoma_Homo sapiens_hsa052110.14558679
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.14542427
133Prolactin signaling pathway_Homo sapiens_hsa049170.14516706

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