IL1R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte migration involved in inflammatory response (GO:0002523)6.04512140
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.18676867
3negative regulation of cell killing (GO:0031342)5.18676867
4detection of bacterium (GO:0016045)5.03284602
5regulation of dendritic cell antigen processing and presentation (GO:0002604)4.97895748
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.97864080
7positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.92492690
8detection of other organism (GO:0098543)4.88997131
9antigen processing and presentation of endogenous antigen (GO:0019883)4.85729880
10positive regulation of respiratory burst (GO:0060267)4.84545253
11negative regulation of interleukin-12 production (GO:0032695)4.83837223
12leukocyte aggregation (GO:0070486)4.83495529
13positive regulation of antigen processing and presentation (GO:0002579)4.49924582
14regulation of interferon-beta biosynthetic process (GO:0045357)4.43097896
15cellular extravasation (GO:0045123)4.37626358
16response to peptidoglycan (GO:0032494)4.36887474
17response to host immune response (GO:0052572)4.22364029
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22364029
19neutrophil activation involved in immune response (GO:0002283)4.20816748
20microglial cell activation (GO:0001774)4.19464478
21detection of external biotic stimulus (GO:0098581)4.17121480
22detection of molecule of bacterial origin (GO:0032490)3.97308221
23macrophage activation involved in immune response (GO:0002281)3.93546956
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.88211479
25response to host (GO:0075136)3.88211479
26response to host defenses (GO:0052200)3.88211479
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80670544
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80670544
29regulation of antigen processing and presentation (GO:0002577)3.80250688
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.78800796
31positive regulation of granulocyte chemotaxis (GO:0071624)3.78539299
32response to muramyl dipeptide (GO:0032495)3.67850837
33regulation of gamma-delta T cell activation (GO:0046643)3.64979869
34regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.64284747
35positive regulation of neutrophil migration (GO:1902624)3.63720725
36positive regulation of neutrophil chemotaxis (GO:0090023)3.63720725
37germinal center formation (GO:0002467)3.63320367
38NIK/NF-kappaB signaling (GO:0038061)3.60805866
39regulation of B cell receptor signaling pathway (GO:0050855)3.59679724
40response to interleukin-15 (GO:0070672)3.59423449
41detection of biotic stimulus (GO:0009595)3.56450139
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.53722675
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.47388297
44regulation of T-helper 2 cell differentiation (GO:0045628)3.47191685
45positive regulation of gamma-delta T cell activation (GO:0046645)3.45413392
46type I interferon signaling pathway (GO:0060337)3.43047903
47cellular response to type I interferon (GO:0071357)3.43047903
48regulation of hypersensitivity (GO:0002883)3.43045571
49response to type I interferon (GO:0034340)3.39786570
50negative regulation of leukocyte mediated immunity (GO:0002704)3.38912479
51production of molecular mediator involved in inflammatory response (GO:0002532)3.32333975
52defense response to protozoan (GO:0042832)3.30687115
53neutrophil activation (GO:0042119)3.29216770
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28787881
55negative regulation of T cell mediated immunity (GO:0002710)3.25383421
56respiratory burst (GO:0045730)3.24260656
57cellular response to interleukin-15 (GO:0071350)3.22283269
58granulocyte activation (GO:0036230)3.21165168
59regulation of mast cell activation (GO:0033003)3.21018797
60T-helper 1 type immune response (GO:0042088)3.18992569
61regulation of leukocyte degranulation (GO:0043300)3.17216331
62negative regulation of T-helper cell differentiation (GO:0045623)3.17124196
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17124196
64regulation of neutrophil migration (GO:1902622)3.16997482
65regulation of neutrophil chemotaxis (GO:0090022)3.16997482
66myeloid dendritic cell differentiation (GO:0043011)3.16095806
67positive regulation of cellular amide metabolic process (GO:0034250)3.15680747
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15614479
69myeloid leukocyte mediated immunity (GO:0002444)3.15517075
70immunoglobulin mediated immune response (GO:0016064)3.14955323
71positive regulation of macrophage activation (GO:0043032)3.13244790
72positive regulation of mast cell activation (GO:0033005)3.12134699
73neutrophil mediated immunity (GO:0002446)3.10812597
74B cell mediated immunity (GO:0019724)3.08825256
75positive regulation of monocyte chemotaxis (GO:0090026)3.07858184
76positive regulation of interferon-alpha production (GO:0032727)3.07361399
77myeloid leukocyte activation (GO:0002274)3.06233289
78negative regulation of cytokine production involved in immune response (GO:0002719)3.04284605
79regulation of granulocyte chemotaxis (GO:0071622)3.04203023
80positive regulation of mast cell activation involved in immune response (GO:0033008)3.00906627
81positive regulation of mast cell degranulation (GO:0043306)3.00906627
82regulation of tolerance induction (GO:0002643)2.99671565
83myeloid cell activation involved in immune response (GO:0002275)2.99520027
84myeloid dendritic cell activation (GO:0001773)2.98144526
85response to protozoan (GO:0001562)2.97795033
86positive regulation of T-helper 1 type immune response (GO:0002827)2.97397573
87regulation of gamma-delta T cell differentiation (GO:0045586)2.96598777
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94606799
89regulation of interferon-alpha production (GO:0032647)2.92874182
90negative regulation of interleukin-6 production (GO:0032715)2.92396783
91leukocyte degranulation (GO:0043299)2.91595736
92negative regulation of growth of symbiont in host (GO:0044130)2.91282897
93negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.91282897
94modulation of growth of symbiont involved in interaction with host (GO:0044144)2.91282897
95regulation of growth of symbiont in host (GO:0044126)2.91282897
96antigen processing and presentation via MHC class Ib (GO:0002475)2.90562649
97hydrogen peroxide biosynthetic process (GO:0050665)2.89666781
98superoxide anion generation (GO:0042554)2.88283918
99regulation of mast cell degranulation (GO:0043304)2.87828085
100regulation of monocyte chemotaxis (GO:0090025)2.87491115
101regulation of podosome assembly (GO:0071801)2.87276322
102T-helper cell differentiation (GO:0042093)2.86414984
103CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86414984
104regulation of macrophage cytokine production (GO:0010935)2.85810786
105dendritic cell migration (GO:0036336)2.85121242
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84398881
107defense response to fungus (GO:0050832)2.84155432
108regulation of T cell tolerance induction (GO:0002664)2.83284561
109regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.82652969
110leukotriene metabolic process (GO:0006691)2.81671233
111neutrophil chemotaxis (GO:0030593)2.81313089
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81236222
113granulocyte chemotaxis (GO:0071621)2.81214151
114sequestering of metal ion (GO:0051238)2.81148872
115positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.80665641
116lipoxygenase pathway (GO:0019372)2.79208794
117positive regulation by symbiont of host defense response (GO:0052509)2.79074970
118modulation by symbiont of host defense response (GO:0052031)2.79074970
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79074970
120modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79074970
121positive regulation by organism of defense response of other organism involved in symbiotic interact2.79074970
122modulation by symbiont of host immune response (GO:0052553)2.79074970
123negative regulation of interleukin-17 production (GO:0032700)2.78867888
124dendritic cell chemotaxis (GO:0002407)2.78382385
125positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.77601062
126response to fungus (GO:0009620)2.77562268
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.76515998
128regulation of T-helper 1 cell differentiation (GO:0045625)2.74124972
129positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73322934
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72921840
131neutrophil migration (GO:1990266)2.72866599
132macrophage activation (GO:0042116)2.72805132
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71390706
134growth hormone receptor signaling pathway (GO:0060396)2.71054244
135T cell activation involved in immune response (GO:0002286)2.70940945
136negative regulation of complement activation (GO:0045916)2.69699391
137regulation of activation of Janus kinase activity (GO:0010533)2.69694697
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.68888551
139regulation of mast cell activation involved in immune response (GO:0033006)2.68830091
140positive regulation of interleukin-12 production (GO:0032735)2.68598310
141positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.67844792
142tolerance induction (GO:0002507)2.66565032
143interferon-gamma-mediated signaling pathway (GO:0060333)2.65508794
144positive regulation of tumor necrosis factor production (GO:0032760)2.64146988
145positive regulation of humoral immune response (GO:0002922)2.63592067
146leukocyte cell-cell adhesion (GO:0007159)2.63243408
147positive regulation of toll-like receptor signaling pathway (GO:0034123)2.63084834
148natural killer cell activation involved in immune response (GO:0002323)2.63052033
149negative regulation of bone resorption (GO:0045779)2.62891276
150regulation of respiratory burst (GO:0060263)2.62786690
151defense response to Gram-positive bacterium (GO:0050830)2.62001943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.08376922
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.83308217
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.46320119
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.34991583
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02276414
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83260306
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.22730372
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.21121324
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05307039
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00370183
11* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.98366046
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.96389906
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86948149
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73581956
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72070035
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.54343329
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.53530073
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39681106
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27808271
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23100944
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15134004
22RUNX_20019798_ChIP-Seq_JUKART_Human2.07782436
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06558030
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92952201
25MYB_26560356_Chip-Seq_TH2_Human1.86353281
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.78778777
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77189542
28SCL_19346495_ChIP-Seq_HPC-7_Human1.75503189
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74542016
30VDR_24787735_ChIP-Seq_THP-1_Human1.72353056
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71759843
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71721757
33* SPI1_23547873_ChIP-Seq_NB4_Human1.69116419
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.67847398
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66783655
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62742997
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61309853
38MAF_26560356_Chip-Seq_TH1_Human1.59556396
39* VDR_24763502_ChIP-Seq_THP-1_Human1.52947890
40GATA1_22025678_ChIP-Seq_K562_Human1.50415994
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.46357821
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.46113686
43* PU_27001747_Chip-Seq_BMDM_Mouse1.44636229
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42544360
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42178135
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39224998
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.38668257
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38512118
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37850338
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36910511
51SPI1_23127762_ChIP-Seq_K562_Human1.36020873
52MYC_22102868_ChIP-Seq_BL_Human1.35888879
53KDM2B_26808549_Chip-Seq_DND41_Human1.34547577
54* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32984533
55* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32984533
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31998547
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30694969
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.28661233
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27688594
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25095656
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24184556
62MYB_26560356_Chip-Seq_TH1_Human1.23577109
63GATA3_26560356_Chip-Seq_TH2_Human1.23524342
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22125648
65GATA3_27048872_Chip-Seq_THYMUS_Human1.20532869
66EGR1_19032775_ChIP-ChIP_M12_Human1.20179323
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18531300
68* VDR_21846776_ChIP-Seq_THP-1_Human1.17501405
69* SOX2_20726797_ChIP-Seq_SW620_Human1.16517911
70* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15062190
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14958882
72* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12802187
73* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12682926
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.11899040
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11586234
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11327134
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07809495
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07289358
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06278159
80CJUN_26792858_Chip-Seq_BT549_Human1.06057641
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05651057
82LXR_22292898_ChIP-Seq_THP-1_Human1.05379311
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05078269
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04301476
85TCF7_22412390_ChIP-Seq_EML_Mouse1.02625303
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02283941
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00972410
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.00707434
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97769587
90* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97586897
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97219718
92* UTX_26944678_Chip-Seq_JUKART_Human0.95555266
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94858083
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94818873
95GATA1_19941826_ChIP-Seq_K562_Human0.92855231
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92091705
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.92033463
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91544156
99BCL6_27268052_Chip-Seq_Bcells_Human0.90704538
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90520727
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90074234
102* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89866317
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89360198
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.88733886
105* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87134556
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85628662
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85526778
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85270508
109BCOR_27268052_Chip-Seq_Bcells_Human0.84963285
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84601265
111GATA2_19941826_ChIP-Seq_K562_Human0.84109897
112* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82882749
113* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82777969
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82697851
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82578851
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82403620
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82324830
118SPI1_20517297_ChIP-Seq_HL60_Human0.81510741
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78938780
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78938780
121TP63_23658742_ChIP-Seq_EP156T_Human0.77517564
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77137441
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76965969
124MAF_26560356_Chip-Seq_TH2_Human0.75953120
125SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72921657
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72658527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.21810844
2MP0002254_reproductive_system_inflammat3.67580741
3MP0009785_altered_susceptibility_to3.41859291
4MP0003436_decreased_susceptibility_to3.37197167
5MP0002148_abnormal_hypersensitivity_rea3.22886475
6MP0000685_abnormal_immune_system3.13913124
7MP0003303_peritoneal_inflammation3.01246790
8MP0002419_abnormal_innate_immunity2.79954816
9MP0004510_myositis2.75981893
10MP0005671_abnormal_response_to2.69020464
11MP0001790_abnormal_immune_system2.68814486
12MP0005387_immune_system_phenotype2.68814486
13MP0005025_abnormal_response_to2.64869780
14MP0005000_abnormal_immune_tolerance2.61749478
15MP0001853_heart_inflammation2.49798531
16MP0003724_increased_susceptibility_to2.47322586
17MP0001800_abnormal_humoral_immune2.35676962
18MP0002452_abnormal_antigen_presenting2.23194601
19MP0004947_skin_inflammation2.20990795
20MP0002723_abnormal_immune_serum2.14086948
21MP0002138_abnormal_hepatobiliary_system2.09813971
22MP0001819_abnormal_immune_cell2.02833219
23MP0002420_abnormal_adaptive_immunity2.01615767
24MP0001533_abnormal_skeleton_physiology2.01351113
25MP0002405_respiratory_system_inflammati1.98816064
26MP0008260_abnormal_autophagy1.96591937
27MP0003453_abnormal_keratinocyte_physiol1.95792870
28MP0010234_abnormal_vibrissa_follicle1.90159377
29MP0002796_impaired_skin_barrier1.85265328
30MP0002877_abnormal_melanocyte_morpholog1.85044577
31MP0005451_abnormal_body_composition1.84429071
32MP0009278_abnormal_bone_marrow1.81505655
33MP0001845_abnormal_inflammatory_respons1.79586188
34MP0005310_abnormal_salivary_gland1.79003598
35MP0006082_CNS_inflammation1.76094287
36MP0003448_altered_tumor_morphology1.75400023
37MP0003172_abnormal_lysosome_physiology1.73346467
38MP0004381_abnormal_hair_follicle1.67937910
39MP0009764_decreased_sensitivity_to1.67286824
40MP0002132_abnormal_respiratory_system1.64678538
41MP0001542_abnormal_bone_strength1.60114462
42MP0000858_altered_metastatic_potential1.59786495
43MP0010155_abnormal_intestine_physiology1.59093412
44MP0000383_abnormal_hair_follicle1.57467395
45MP0005464_abnormal_platelet_physiology1.57356032
46MP0001851_eye_inflammation1.50876669
47MP0003300_gastrointestinal_ulcer1.48277294
48MP0000604_amyloidosis1.46146622
49MP0003941_abnormal_skin_development1.46142069
50MP0002060_abnormal_skin_morphology1.42582423
51MP0005275_abnormal_skin_tensile1.42192568
52MP0010678_abnormal_skin_adnexa1.38221188
53MP0003566_abnormal_cell_adhesion1.36712721
54MP0008004_abnormal_stomach_pH1.35928682
55MP0000716_abnormal_immune_system1.35751062
56MP0001216_abnormal_epidermal_layer1.34630624
57MP0002277_abnormal_respiratory_mucosa1.33657960
58MP0000343_altered_response_to1.33582115
59MP0002998_abnormal_bone_remodeling1.33572562
60MP0010352_gastrointestinal_tract_polyps1.32788862
61MP0003828_pulmonary_edema1.29098529
62MP0002398_abnormal_bone_marrow1.26131828
63MP0008469_abnormal_protein_level1.21753983
64MP0002006_tumorigenesis1.21007452
65MP0005397_hematopoietic_system_phenotyp1.18989802
66MP0001545_abnormal_hematopoietic_system1.18989802
67MP0003806_abnormal_nucleotide_metabolis1.16741704
68MP0002166_altered_tumor_susceptibility1.14607927
69MP0009333_abnormal_splenocyte_physiolog1.13916064
70MP0000465_gastrointestinal_hemorrhage1.13535422
71MP0003191_abnormal_cellular_cholesterol1.13311305
72MP0005023_abnormal_wound_healing1.11143799
73MP0005166_decreased_susceptibility_to1.10962014
74MP0005390_skeleton_phenotype1.09580734
75MP0001348_abnormal_lacrimal_gland1.08962773
76MP0002396_abnormal_hematopoietic_system1.08763393
77MP0005164_abnormal_response_to1.08086442
78MP0003045_fibrosis1.07712939
79MP0003075_altered_response_to1.07430964
80MP0003763_abnormal_thymus_physiology1.07243988
81MP0002429_abnormal_blood_cell1.05553780
82MP0008438_abnormal_cutaneous_collagen1.03418392
83MP0002933_joint_inflammation1.01939000
84MP0003690_abnormal_glial_cell0.99802656
85MP0002722_abnormal_immune_system0.99136565
86MP0003183_abnormal_peptide_metabolism0.98461565
87MP0003656_abnormal_erythrocyte_physiolo0.95969593
88MP0009840_abnormal_foam_cell0.95032928
89MP0005058_abnormal_lysosome_morphology0.94383678
90MP0004782_abnormal_surfactant_physiolog0.94150786
91MP0005501_abnormal_skin_physiology0.93635272
92MP0000703_abnormal_thymus_morphology0.93319242
93MP0004883_abnormal_blood_vessel0.92688824
94MP0009763_increased_sensitivity_to0.90681018
95MP0000681_abnormal_thyroid_gland0.87063311
96MP0003866_abnormal_defecation0.86318215
97MP0003279_aneurysm0.86277594
98MP0009931_abnormal_skin_appearance0.85557309
99MP0000689_abnormal_spleen_morphology0.83703787
100MP0001663_abnormal_digestive_system0.83582646
101MP0001191_abnormal_skin_condition0.82460864
102MP0010771_integument_phenotype0.82389666
103MP0001346_abnormal_lacrimal_gland0.79269220
104MP0000569_abnormal_digit_pigmentation0.78333555
105MP0001873_stomach_inflammation0.78291735
106MP0005167_abnormal_blood-brain_barrier0.77858040
107MP0000767_abnormal_smooth_muscle0.77042543
108MP0009765_abnormal_xenobiotic_induced0.76681504
109MP0001958_emphysema0.74927161
110MP0001243_abnormal_dermal_layer0.74337674
111MP0005076_abnormal_cell_differentiation0.72902651
112MP0000377_abnormal_hair_follicle0.72517901
113MP0002332_abnormal_exercise_endurance0.71834854
114MP0001881_abnormal_mammary_gland0.71762143
115MP0000249_abnormal_blood_vessel0.71744831
116MP0003795_abnormal_bone_structure0.70454510
117MP0003638_abnormal_response/metabolism_0.69547325
118MP0005174_abnormal_tail_pigmentation0.69214368
119MP0008874_decreased_physiological_sensi0.67086665
120MP0003221_abnormal_cardiomyocyte_apopto0.65619871
121MP0005319_abnormal_enzyme/_coenzyme0.62135533
122MP0000015_abnormal_ear_pigmentation0.61065401
123MP0003091_abnormal_cell_migration0.59778329
124MP0004808_abnormal_hematopoietic_stem0.58485124
125MP0000920_abnormal_myelination0.56499146
126MP0004264_abnormal_extraembryonic_tissu0.53376142
127MP0000609_abnormal_liver_physiology0.52228249

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.01242681
2Recurrent abscess formation (HP:0002722)5.20957810
3Myositis (HP:0100614)5.00485720
4Recurrent bacterial skin infections (HP:0005406)4.91140329
5Orchitis (HP:0100796)4.68102988
6Retrobulbar optic neuritis (HP:0100654)4.32372523
7Optic neuritis (HP:0100653)4.32372523
8Recurrent gram-negative bacterial infections (HP:0005420)4.08714431
9Spondylolisthesis (HP:0003302)4.03147541
10Osteolytic defects of the hand bones (HP:0009699)3.94229039
11Osteolytic defects of the phalanges of the hand (HP:0009771)3.94229039
12Abnormality of macrophages (HP:0004311)3.91488594
13Absent frontal sinuses (HP:0002688)3.85055119
14Elevated erythrocyte sedimentation rate (HP:0003565)3.77342452
15Persistence of primary teeth (HP:0006335)3.70208184
16Obstructive lung disease (HP:0006536)3.66827344
17Chronic obstructive pulmonary disease (HP:0006510)3.66827344
18Mediastinal lymphadenopathy (HP:0100721)3.62583735
19Systemic lupus erythematosus (HP:0002725)3.52295606
20Recurrent fungal infections (HP:0002841)3.42846200
21Hydroxyprolinuria (HP:0003080)3.32020784
22Abnormality of proline metabolism (HP:0010907)3.32020784
23Vacuolated lymphocytes (HP:0001922)3.27567254
24Keratoconjunctivitis sicca (HP:0001097)3.26574721
25Chronic otitis media (HP:0000389)3.18689857
26Recurrent skin infections (HP:0001581)3.18224300
27Gastrointestinal infarctions (HP:0005244)3.14807518
28Keratoconjunctivitis (HP:0001096)3.09754143
29Gingivitis (HP:0000230)3.05286358
30Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.03612023
31Increased IgE level (HP:0003212)3.02245847
32Chest pain (HP:0100749)2.96850881
33Amyloidosis (HP:0011034)2.95705982
34Episodic fever (HP:0001954)2.95570761
35Stomatitis (HP:0010280)2.94193258
36Prolonged bleeding time (HP:0003010)2.93199169
37Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.90776526
38Thick nail (HP:0001805)2.89839681
39Vasculitis (HP:0002633)2.80615852
40Meningitis (HP:0001287)2.79161224
41Osteomyelitis (HP:0002754)2.78790607
42Hypochromic microcytic anemia (HP:0004840)2.77245008
43Cellulitis (HP:0100658)2.74178301
44Abnormality of the frontal sinuses (HP:0002687)2.69104394
45Pustule (HP:0200039)2.67214051
46Epistaxis (HP:0000421)2.66973694
47Hemoptysis (HP:0002105)2.65130569
48Arterial thrombosis (HP:0004420)2.63125317
49Pulmonary infiltrates (HP:0002113)2.60764553
50Interstitial pulmonary disease (HP:0006530)2.60397579
51T lymphocytopenia (HP:0005403)2.56447350
52Hypochromic anemia (HP:0001931)2.56379484
53Gangrene (HP:0100758)2.55966154
54Abnormality of T cell number (HP:0011839)2.53699039
55Recurrent cutaneous fungal infections (HP:0011370)2.49074364
56Chronic mucocutaneous candidiasis (HP:0002728)2.49074364
57Abnormality of liposaccharide metabolism (HP:0010968)2.47352778
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.47352778
59Abnormality of glycolipid metabolism (HP:0010969)2.47352778
60Urticaria (HP:0001025)2.45102234
61Plantar hyperkeratosis (HP:0007556)2.43246175
62Inflammation of the large intestine (HP:0002037)2.40040449
63Increased IgM level (HP:0003496)2.37209976
64Premature loss of primary teeth (HP:0006323)2.36668953
65Mucopolysacchariduria (HP:0008155)2.32362438
66Urinary glycosaminoglycan excretion (HP:0003541)2.32362438
67Petechiae (HP:0000967)2.31315432
68Leukocytosis (HP:0001974)2.29601389
69Abnormality of the peritoneum (HP:0002585)2.28593440
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27726956
71Peritonitis (HP:0002586)2.27649547
72Gastrointestinal inflammation (HP:0004386)2.26873893
73Recurrent viral infections (HP:0004429)2.26800559
74Increased cerebral lipofuscin (HP:0011813)2.26135726
75Gingival bleeding (HP:0000225)2.25516048
76Spontaneous hematomas (HP:0007420)2.24624699
77Purpura (HP:0000979)2.22327987
78Ridged nail (HP:0001807)2.20202016
79Xerostomia (HP:0000217)2.19324922
80Abnormality of the endocardium (HP:0004306)2.18807850
81Keratitis (HP:0000491)2.18493549
82Recurrent bronchitis (HP:0002837)2.18205877
83Skin ulcer (HP:0200042)2.17956682
84Segmental peripheral demyelination/remyelination (HP:0003481)2.16846596
85Loss of speech (HP:0002371)2.15961440
86Periodontitis (HP:0000704)2.13737897
87Abnormality of T cells (HP:0002843)2.13721337
88Milia (HP:0001056)2.12697317
89Palmoplantar hyperkeratosis (HP:0000972)2.12624383
90Acne (HP:0001061)2.12277924
91Glomerulopathy (HP:0100820)2.11069300
92Encephalitis (HP:0002383)2.10660386
93Granulocytopenia (HP:0001913)2.09924206
94Thickened calvaria (HP:0002684)2.09680980
95Cervical subluxation (HP:0003308)2.09568152
96Dysostosis multiplex (HP:0000943)2.09345399
97Increased serum ferritin (HP:0003281)2.08896192
98Delayed closure of the anterior fontanelle (HP:0001476)2.07844120
99Eosinophilia (HP:0001880)2.07278490
100Joint swelling (HP:0001386)2.06791307
101Hepatosplenomegaly (HP:0001433)2.06622378
102Abnormal hemoglobin (HP:0011902)2.05272188
103Abnormality of polysaccharide metabolism (HP:0011012)2.04122607
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04122607
105Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04122607
106Cheilitis (HP:0100825)2.01657164
107Anorexia (HP:0002039)2.01645275
108Vertigo (HP:0002321)2.01465233
109Autoimmune thrombocytopenia (HP:0001973)2.00993510
110Disinhibition (HP:0000734)2.00474964
111Sepsis (HP:0100806)1.99666666
112IgM deficiency (HP:0002850)1.99208065
113Parakeratosis (HP:0001036)1.99201534
114Hematochezia (HP:0002573)1.99176715
115Nasal polyposis (HP:0100582)1.98909337
116Abnormality of the nasal mucosa (HP:0000433)1.98420730
117Erythema (HP:0010783)1.97993676
118Right ventricular cardiomyopathy (HP:0011663)1.97939944
119Microcytic anemia (HP:0001935)1.97053824
120Hypotrichosis (HP:0001006)1.97018701
121Palmar hyperkeratosis (HP:0010765)1.96459863
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.96213415
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.95834718
124Polyneuropathy (HP:0001271)1.95144828
125Distal lower limb muscle weakness (HP:0009053)1.95080649
126Abnormality of the pericardium (HP:0001697)1.94798063
127Autoimmune hemolytic anemia (HP:0001890)1.92990945
128Malnutrition (HP:0004395)1.91952140
129Abnormality of iron homeostasis (HP:0011031)1.91904654
130Alopecia of scalp (HP:0002293)1.91755380
131Slow saccadic eye movements (HP:0000514)1.91556983
132Hypergammaglobulinemia (HP:0010702)1.91394070
133Ulnar deviation of the wrist (HP:0003049)1.90220675
134Fragile nails (HP:0001808)1.88026021
135Recurrent pneumonia (HP:0006532)1.87281078
136Abnormality of the pleura (HP:0002103)1.87090739
137Onycholysis (HP:0001806)1.86066442
138Pulmonary embolism (HP:0002204)1.85833232
139Colitis (HP:0002583)1.85359319
140Abnormality of T cell physiology (HP:0011840)1.83679082
141Abnormal platelet volume (HP:0011876)1.83155570
142Skin rash (HP:0000988)1.82484066
143Thrombophlebitis (HP:0004418)1.76286245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.36274449
2BLK4.03666199
3EPHB13.07807069
4IRAK42.97202697
5MAP4K12.67075756
6TYK22.51725395
7RIPK42.51004225
8TRPM72.47135855
9TBK12.39687820
10IRAK32.34947535
11MST42.19481143
12JAK32.12126297
13IKBKB2.11218423
14CSK2.10940554
15ERN12.08986661
16TXK2.08350821
17EPHA32.08190930
18TGFBR22.08103948
19IKBKE1.98549536
20ERBB31.98294134
21TNK21.80727037
22MAP3K131.77619531
23FGR1.66798205
24JAK11.64873221
25STK101.60396010
26PRPF4B1.54603455
27CHUK1.54185129
28BMPR21.50877494
29STK241.49137455
30BTK1.48751081
31KSR21.48451576
32HCK1.47184475
33IRAK21.46097612
34MAP3K31.46047671
35TEC1.42101621
36ZAP701.41393242
37MST1R1.36059858
38MAP3K61.32965219
39ITK1.29950792
40FGFR41.29090860
41CLK11.27851255
42SIK31.26887817
43MAP2K31.25055890
44MAP3K121.22392676
45PIM21.19341846
46LRRK21.17593832
47FGFR31.17159330
48JAK21.17090984
49YES11.15246423
50SYK1.14996494
51TAOK31.14086133
52KIT1.13607338
53MARK31.09683123
54MAPKAPK31.03738893
55TESK11.02664074
56TAOK21.01195016
57PIK3CG0.97675447
58PIM10.97186651
59IRAK10.92662746
60FES0.92372362
61PTK60.91957996
62LCK0.90891561
63MARK20.90778146
64NLK0.89749879
65LYN0.85450559
66CDC42BPA0.85233483
67MAP3K10.83518734
68EIF2AK20.82322767
69PRKD20.81469767
70MAPKAPK20.81373468
71LIMK10.80923496
72PDPK10.76720307
73MAP3K50.75522421
74MATK0.75384218
75CSF1R0.75117743
76RPS6KA40.68288523
77MAP2K40.66766280
78TTN0.66575741
79TESK20.62915807
80GRK60.62534369
81PTK2B0.60445388
82SGK30.58657409
83KSR10.58351572
84GRK70.57667274
85RIPK10.57303903
86DAPK20.56094640
87MAPKAPK50.55413875
88RAF10.53675115
89MAP2K60.53072188
90ABL10.52923228
91PRKCD0.52169999
92SIK20.51148493
93MAPK120.49223973
94ALK0.48771781
95MAP3K70.48633057
96PRKCQ0.48477284
97MAPK70.47627697
98DMPK0.47371906
99RET0.47044678
100TRIB30.45423478
101MOS0.44896761
102FRK0.44797706
103WNK10.44048454
104PTK20.42389339
105STK30.40808772
106STK110.40231334
107STK380.39567939
108MAPK40.39279676
109PRKG20.39117808
110CDK190.38197016
111MAP3K110.37714779
112SIK10.36508100
113FYN0.36070043
114CDK60.35922914
115DYRK1B0.35900463
116MYLK0.35398240
117PBK0.34640090
118SGK20.34578848
119SMG10.34438013
120ACVR1B0.33050288
121RPS6KA60.29511960
122IGF1R0.28907457
123EGFR0.28405302
124PDK10.27629723
125PAK40.26859128
126KDR0.24474815
127MAP3K20.24212442
128BMX0.24042170
129FER0.23848282
130NEK90.22686236
131HIPK20.22291089
132RPS6KL10.22202669
133RPS6KC10.22202669
134TAOK10.22060021
135GSK3A0.21461168
136RPS6KA10.20990460

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.98904793
2Leishmaniasis_Homo sapiens_hsa051402.98847532
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75989806
4Osteoclast differentiation_Homo sapiens_hsa043802.68490141
5Staphylococcus aureus infection_Homo sapiens_hsa051502.54075409
6Allograft rejection_Homo sapiens_hsa053302.53732516
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.53545242
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30085243
9Graft-versus-host disease_Homo sapiens_hsa053322.19732063
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.02824817
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.99455683
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98856004
13Pertussis_Homo sapiens_hsa051331.98197387
14TNF signaling pathway_Homo sapiens_hsa046681.86116238
15Tuberculosis_Homo sapiens_hsa051521.85555237
16Legionellosis_Homo sapiens_hsa051341.78288542
17Rheumatoid arthritis_Homo sapiens_hsa053231.77525808
18Autoimmune thyroid disease_Homo sapiens_hsa053201.76887738
19* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.75299584
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.74536083
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.73238682
22* Hematopoietic cell lineage_Homo sapiens_hsa046401.70527110
23Measles_Homo sapiens_hsa051621.69910189
24Toxoplasmosis_Homo sapiens_hsa051451.62015678
25Salmonella infection_Homo sapiens_hsa051321.54164453
26Apoptosis_Homo sapiens_hsa042101.46014882
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45024982
28Primary immunodeficiency_Homo sapiens_hsa053401.44332053
29B cell receptor signaling pathway_Homo sapiens_hsa046621.44273202
30Lysosome_Homo sapiens_hsa041421.44131589
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.42288204
32Chemokine signaling pathway_Homo sapiens_hsa040621.41547003
33Antigen processing and presentation_Homo sapiens_hsa046121.36619238
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34605620
35Shigellosis_Homo sapiens_hsa051311.33863371
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31123929
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27250944
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26029333
39Malaria_Homo sapiens_hsa051441.25413251
40Influenza A_Homo sapiens_hsa051641.25137409
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22744777
42Phagosome_Homo sapiens_hsa041451.18377136
43T cell receptor signaling pathway_Homo sapiens_hsa046601.18185958
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17712059
45Type I diabetes mellitus_Homo sapiens_hsa049401.15794988
46Histidine metabolism_Homo sapiens_hsa003401.11050155
47Other glycan degradation_Homo sapiens_hsa005111.10947538
48Viral myocarditis_Homo sapiens_hsa054161.09059684
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06162384
50Herpes simplex infection_Homo sapiens_hsa051681.05311982
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03736907
52African trypanosomiasis_Homo sapiens_hsa051430.97086790
53Hepatitis B_Homo sapiens_hsa051610.95444822
54Non-small cell lung cancer_Homo sapiens_hsa052230.91385924
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90804998
56* Amoebiasis_Homo sapiens_hsa051460.87962240
57Acute myeloid leukemia_Homo sapiens_hsa052210.87539237
58Complement and coagulation cascades_Homo sapiens_hsa046100.84914488
59Hepatitis C_Homo sapiens_hsa051600.84102575
60Platelet activation_Homo sapiens_hsa046110.80271970
61Arachidonic acid metabolism_Homo sapiens_hsa005900.79196599
62Renal cell carcinoma_Homo sapiens_hsa052110.79186760
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75053903
64Pancreatic cancer_Homo sapiens_hsa052120.74232571
65Endocytosis_Homo sapiens_hsa041440.72415070
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71190786
67Dorso-ventral axis formation_Homo sapiens_hsa043200.71126146
68* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69542542
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65334885
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64787567
71Chronic myeloid leukemia_Homo sapiens_hsa052200.64218802
72Sphingolipid metabolism_Homo sapiens_hsa006000.60494635
73Prolactin signaling pathway_Homo sapiens_hsa049170.60360804
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60293575
75HIF-1 signaling pathway_Homo sapiens_hsa040660.59572942
76Notch signaling pathway_Homo sapiens_hsa043300.59127231
77Small cell lung cancer_Homo sapiens_hsa052220.58667032
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.58199364
79Proteoglycans in cancer_Homo sapiens_hsa052050.56828316
80VEGF signaling pathway_Homo sapiens_hsa043700.55934623
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55772068
82GnRH signaling pathway_Homo sapiens_hsa049120.55461589
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52749986
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51822792
85Type II diabetes mellitus_Homo sapiens_hsa049300.50008354
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.48783578
87Focal adhesion_Homo sapiens_hsa045100.47119401
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47097595
89Caffeine metabolism_Homo sapiens_hsa002320.46923480
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.46741003
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46466803
92Bladder cancer_Homo sapiens_hsa052190.44155273
93Choline metabolism in cancer_Homo sapiens_hsa052310.42725688
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.41283831
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40871692
96FoxO signaling pathway_Homo sapiens_hsa040680.40829174
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40510071
98Endometrial cancer_Homo sapiens_hsa052130.39454624
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39324172
100Epstein-Barr virus infection_Homo sapiens_hsa051690.38580399
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38139958
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37014651
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36940081
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36929737
105Rap1 signaling pathway_Homo sapiens_hsa040150.36417436
106Collecting duct acid secretion_Homo sapiens_hsa049660.35310153
107Insulin resistance_Homo sapiens_hsa049310.34870743
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34579849
109Galactose metabolism_Homo sapiens_hsa000520.33984649
110mTOR signaling pathway_Homo sapiens_hsa041500.33767976
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.32471836
112Ovarian steroidogenesis_Homo sapiens_hsa049130.31115979
113Ras signaling pathway_Homo sapiens_hsa040140.30157494
114* MAPK signaling pathway_Homo sapiens_hsa040100.29790013
115Adherens junction_Homo sapiens_hsa045200.29409247
116* HTLV-I infection_Homo sapiens_hsa051660.29134066
117Pathways in cancer_Homo sapiens_hsa052000.28783290
118p53 signaling pathway_Homo sapiens_hsa041150.28613295
119ECM-receptor interaction_Homo sapiens_hsa045120.28049059
120Prostate cancer_Homo sapiens_hsa052150.27151451
121Viral carcinogenesis_Homo sapiens_hsa052030.26720321
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26477970
123Phenylalanine metabolism_Homo sapiens_hsa003600.26447639
124MicroRNAs in cancer_Homo sapiens_hsa052060.25084321

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