IL1RAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.20475374
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.20475374
3L-phenylalanine metabolic process (GO:0006558)6.56501853
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56501853
5aromatic amino acid family catabolic process (GO:0009074)5.85249241
6fatty acid elongation (GO:0030497)5.75095422
7axon ensheathment in central nervous system (GO:0032291)5.74390929
8central nervous system myelination (GO:0022010)5.74390929
9bile acid biosynthetic process (GO:0006699)5.14528540
10detection of molecule of bacterial origin (GO:0032490)4.81856734
11alpha-linolenic acid metabolic process (GO:0036109)4.66248656
12indole-containing compound catabolic process (GO:0042436)4.63953892
13indolalkylamine catabolic process (GO:0046218)4.63953892
14tryptophan catabolic process (GO:0006569)4.63953892
15glyoxylate metabolic process (GO:0046487)4.61955786
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.57194112
17kynurenine metabolic process (GO:0070189)4.42346490
18tryptophan metabolic process (GO:0006568)4.37219141
19bile acid metabolic process (GO:0008206)4.34645224
20protein carboxylation (GO:0018214)4.25949637
21peptidyl-glutamic acid carboxylation (GO:0017187)4.25949637
22regulation of fibrinolysis (GO:0051917)4.23042692
23complement activation, alternative pathway (GO:0006957)4.21750971
24negative regulation of fibrinolysis (GO:0051918)4.20821845
25hemidesmosome assembly (GO:0031581)4.16853657
26regulation of protein activation cascade (GO:2000257)4.16371017
27aromatic amino acid family metabolic process (GO:0009072)4.13299184
28tyrosine metabolic process (GO:0006570)4.11531989
29coenzyme catabolic process (GO:0009109)4.09793836
30high-density lipoprotein particle remodeling (GO:0034375)4.09554993
31very long-chain fatty acid metabolic process (GO:0000038)4.06754170
32cellular extravasation (GO:0045123)4.05128727
33urea cycle (GO:0000050)4.04672941
34urea metabolic process (GO:0019627)4.04672941
35negative regulation of protein activation cascade (GO:2000258)3.96895459
36cysteine metabolic process (GO:0006534)3.94515688
37regulation of complement activation (GO:0030449)3.90344142
38sulfur amino acid catabolic process (GO:0000098)3.87433406
39negative regulation of complement activation (GO:0045916)3.85725279
40cholesterol biosynthetic process (GO:0006695)3.82191801
41heme transport (GO:0015886)3.82034780
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80083947
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.80083947
44modulation by symbiont of host immune response (GO:0052553)3.80083947
45positive regulation by symbiont of host defense response (GO:0052509)3.80083947
46modulation by symbiont of host defense response (GO:0052031)3.80083947
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80083947
48macrophage activation involved in immune response (GO:0002281)3.79957250
49nitrogen cycle metabolic process (GO:0071941)3.79528690
50detection of external biotic stimulus (GO:0098581)3.75521295
51regulation of triglyceride catabolic process (GO:0010896)3.70136700
52plasma lipoprotein particle clearance (GO:0034381)3.68942485
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.68492149
54response to peptidoglycan (GO:0032494)3.66784950
55fatty-acyl-CoA biosynthetic process (GO:0046949)3.65005334
56long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.64017941
57cofactor catabolic process (GO:0051187)3.63630329
58cellular ketone body metabolic process (GO:0046950)3.62422492
59cellular response to ethanol (GO:0071361)3.62315747
60positive regulation of gamma-delta T cell activation (GO:0046645)3.62036207
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61724047
62opsonization (GO:0008228)3.61679179
63response to methylmercury (GO:0051597)3.61374967
64glutamate metabolic process (GO:0006536)3.61116904
65alpha-amino acid catabolic process (GO:1901606)3.61102915
66regulation of cholesterol esterification (GO:0010872)3.60310002
67neutrophil activation involved in immune response (GO:0002283)3.60179073
68detection of other organism (GO:0098543)3.58074291
69cholesterol efflux (GO:0033344)3.53959097
70amine catabolic process (GO:0009310)3.53224686
71cellular biogenic amine catabolic process (GO:0042402)3.53224686
72plasma lipoprotein particle remodeling (GO:0034369)3.52006512
73protein-lipid complex remodeling (GO:0034368)3.52006512
74macromolecular complex remodeling (GO:0034367)3.52006512
75ethanol oxidation (GO:0006069)3.50504844
76reverse cholesterol transport (GO:0043691)3.48678097
77triglyceride homeostasis (GO:0070328)3.45869099
78acylglycerol homeostasis (GO:0055090)3.45869099
79aldehyde catabolic process (GO:0046185)3.43412252
80sterol biosynthetic process (GO:0016126)3.37418240
81fibrinolysis (GO:0042730)3.36639779
82fatty-acyl-CoA metabolic process (GO:0035337)3.34983177
83cellular amino acid catabolic process (GO:0009063)3.34301255
84indolalkylamine metabolic process (GO:0006586)3.33425273
85acetyl-CoA metabolic process (GO:0006084)3.32437458
86short-chain fatty acid metabolic process (GO:0046459)3.31167037
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.30247486
88cellular glucuronidation (GO:0052695)3.30076310
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.30058071
90neutrophil mediated immunity (GO:0002446)3.29623553
91regulation of bile acid biosynthetic process (GO:0070857)3.29446042
92bile acid and bile salt transport (GO:0015721)3.29256707
93ensheathment of neurons (GO:0007272)3.27977736
94axon ensheathment (GO:0008366)3.27977736
95serine family amino acid catabolic process (GO:0009071)3.27835929
96detection of biotic stimulus (GO:0009595)3.27825230
97negative regulation of lipase activity (GO:0060192)3.26748484
98negative regulation of humoral immune response (GO:0002921)3.26452943
99myelination (GO:0042552)3.25814130
100negative regulation of sterol transport (GO:0032372)3.25741205
101negative regulation of cholesterol transport (GO:0032375)3.25741205
102regulation of interferon-beta biosynthetic process (GO:0045357)3.24880109
103negative regulation of interleukin-12 production (GO:0032695)3.24448054
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.22336820
105serine family amino acid biosynthetic process (GO:0009070)3.22113103
106microglial cell activation (GO:0001774)3.20487136
107dicarboxylic acid biosynthetic process (GO:0043650)3.20217102
108macrophage activation (GO:0042116)3.18099895
109very-low-density lipoprotein particle assembly (GO:0034379)3.17868231
110ketone body metabolic process (GO:1902224)3.16253429
111phospholipid efflux (GO:0033700)3.15660494
112thioester biosynthetic process (GO:0035384)3.15305309
113acyl-CoA biosynthetic process (GO:0071616)3.15305309
114homocysteine metabolic process (GO:0050667)3.15085517
115regulation of B cell receptor signaling pathway (GO:0050855)3.13234186
116L-serine metabolic process (GO:0006563)3.12624367
117thioester metabolic process (GO:0035383)3.12355786
118acyl-CoA metabolic process (GO:0006637)3.12355786
119long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.10395262
120aspartate family amino acid catabolic process (GO:0009068)3.09728582
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08404887
122cholesterol homeostasis (GO:0042632)3.07430644
123iron coordination entity transport (GO:1901678)3.05150495
124low-density lipoprotein particle remodeling (GO:0034374)3.04800045
125positive regulation of lipoprotein lipase activity (GO:0051006)3.04270357
126positive regulation of triglyceride lipase activity (GO:0061365)3.04270357
127regulation of cholesterol biosynthetic process (GO:0045540)3.04132639
128sterol homeostasis (GO:0055092)3.02810753
129serine family amino acid metabolic process (GO:0009069)3.02091430
130detection of bacterium (GO:0016045)3.02030531
131imidazole-containing compound metabolic process (GO:0052803)3.01927788
132glucuronate metabolic process (GO:0019585)3.01143123
133neutrophil activation (GO:0042119)3.00403466
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95125017
135negative regulation of cell killing (GO:0031342)2.95125017
136negative regulation of interleukin-17 production (GO:0032700)2.89981474
137negative regulation of lymphocyte mediated immunity (GO:0002707)2.89978397
138leukocyte migration involved in inflammatory response (GO:0002523)2.88659000
139regulation of gamma-delta T cell activation (GO:0046643)2.86929974
140T-helper 1 type immune response (GO:0042088)2.83937249
141production of molecular mediator involved in inflammatory response (GO:0002532)2.78929364
142granulocyte activation (GO:0036230)2.78788646
143regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.76104116
144interleukin-6-mediated signaling pathway (GO:0070102)2.73403286
145negative regulation of B cell mediated immunity (GO:0002713)2.73352067
146negative regulation of immunoglobulin mediated immune response (GO:0002890)2.73352067
147regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73119516
148iron ion import (GO:0097286)2.70614728
149response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68822920
150response to host immune response (GO:0052572)2.68822920
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65017264
152response to muramyl dipeptide (GO:0032495)2.64637185
153myeloid leukocyte mediated immunity (GO:0002444)2.63383926
154regulation of interleukin-12 biosynthetic process (GO:0045075)2.59813623
155response to interleukin-15 (GO:0070672)2.59469131
156myeloid cell activation involved in immune response (GO:0002275)2.58534223
157antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.56424206
158regulation of interleukin-8 biosynthetic process (GO:0045414)2.54801059
159negative regulation of T cell mediated immunity (GO:0002710)2.54514614
160regulation of interferon-alpha production (GO:0032647)2.54291249
161positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.54091383
162positive regulation of interferon-alpha production (GO:0032727)2.53133316
163germinal center formation (GO:0002467)2.52853442
164regulation of gamma-delta T cell differentiation (GO:0045586)2.49600037
165regulation of mast cell activation (GO:0033003)2.49558543
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48632678
167response to host (GO:0075136)2.48632678
168response to host defenses (GO:0052200)2.48632678
169antigen processing and presentation of endogenous antigen (GO:0019883)2.48089878
170positive regulation of hemostasis (GO:1900048)2.47471330
171positive regulation of blood coagulation (GO:0030194)2.47471330
172positive regulation of coagulation (GO:0050820)2.45827598
173hypotonic response (GO:0006971)2.45751363
174negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.44849625
175cytokine secretion (GO:0050663)2.43512937
176negative regulation of cAMP-mediated signaling (GO:0043951)2.40988063
177regulation of humoral immune response (GO:0002920)2.40040327
178defense response to protozoan (GO:0042832)2.40010992
179negative regulation of Rho protein signal transduction (GO:0035024)2.37130462
180negative regulation of adaptive immune response (GO:0002820)2.37059964
181positive regulation of toll-like receptor signaling pathway (GO:0034123)2.36689877
182positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.36471521
183growth hormone receptor signaling pathway (GO:0060396)2.35482895
184antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.34481003
185response to type I interferon (GO:0034340)2.33950221
186type I interferon signaling pathway (GO:0060337)2.33438016
187cellular response to type I interferon (GO:0071357)2.33438016
188regulation of mast cell activation involved in immune response (GO:0033006)2.33234973
189positive regulation of mast cell activation (GO:0033005)2.32891443
190disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.30253839
191killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.30253839
192negative regulation of leukocyte mediated immunity (GO:0002704)2.28363281
193cellular response to interleukin-15 (GO:0071350)2.28257742
194regulation of acute inflammatory response (GO:0002673)2.28225821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.98836295
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.92731133
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.42954675
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.13108445
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92187556
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.66379020
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60118543
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.40946577
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.27038719
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.92929658
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.84660572
12* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80884048
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.66712021
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66222066
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.61949735
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.35745150
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25065213
18* GBX2_23144817_ChIP-Seq_PC3_Human2.17325143
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17298959
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.14675266
21VDR_24787735_ChIP-Seq_THP-1_Human2.05207846
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04989988
23TAF15_26573619_Chip-Seq_HEK293_Human2.04468484
24RUNX_20019798_ChIP-Seq_JUKART_Human1.96822539
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92140672
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91570609
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79163098
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78699615
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.75094342
30* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73714418
31HTT_18923047_ChIP-ChIP_STHdh_Human1.66174503
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64378682
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62060761
34SCL_19346495_ChIP-Seq_HPC-7_Human1.56771608
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51883654
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51222381
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49211663
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49211663
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48698951
40AR_21572438_ChIP-Seq_LNCaP_Human1.47722713
41TP63_23658742_ChIP-Seq_EP156T_Human1.45465755
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45141168
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44115511
44CJUN_26792858_Chip-Seq_BT549_Human1.43573907
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41017702
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40599902
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40374003
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37394598
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34622666
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34622666
51SPI1_23127762_ChIP-Seq_K562_Human1.34163394
52* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31250161
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31177096
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30933582
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.28802249
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26180105
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.25405676
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25350406
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24061287
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.23976725
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23616318
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23072437
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20879280
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20040133
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19916589
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17369142
67GATA1_22025678_ChIP-Seq_K562_Human1.16498394
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16250236
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.14675551
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14151621
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13431086
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13431086
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13314233
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13300500
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12535255
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11809609
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11660089
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.11433683
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11071318
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10870287
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10144994
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09727502
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.09069541
84P300_19829295_ChIP-Seq_ESCs_Human1.08535753
85* GATA3_26560356_Chip-Seq_TH2_Human1.08264825
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07716612
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07478601
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07146305
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07029837
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06899942
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.06547616
92IGF1R_20145208_ChIP-Seq_DFB_Human1.05207798
93ER_23166858_ChIP-Seq_MCF-7_Human1.05025336
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04936021
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04353358
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.04011618
97MYB_26560356_Chip-Seq_TH2_Human1.03952879
98* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03948122
99EZH2_22144423_ChIP-Seq_EOC_Human1.01991786
100* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01827237
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01259783
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01027575
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00962208
104* EZH2_27294783_Chip-Seq_ESCs_Mouse1.00754211
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00078594
106* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99727876
107VDR_24763502_ChIP-Seq_THP-1_Human0.98008457
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97700559
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96219095
110* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95998882
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.95154167
112* GATA3_27048872_Chip-Seq_THYMUS_Human0.94762740
113DROSHA_22980978_ChIP-Seq_HELA_Human0.94355207
114BCAT_22108803_ChIP-Seq_LS180_Human0.94054703
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93949504
116* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93820467
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93584721
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93377044
119* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93094705
120RXR_22108803_ChIP-Seq_LS180_Human0.92899212
121EZH2_27304074_Chip-Seq_ESCs_Mouse0.92201277
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89280544
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89083268
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88870028
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87610233
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.85809126
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85679575
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85004319
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84610094
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.84523873
131SMAD4_21799915_ChIP-Seq_A2780_Human0.84277402
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84023398
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83194171
134VDR_22108803_ChIP-Seq_LS180_Human0.81990924
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80673538
136* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80263630
137* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79386149
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.79033379
139TP53_18474530_ChIP-ChIP_U2OS_Human0.78800692
140* STAT3_23295773_ChIP-Seq_U87_Human0.78237699
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78003149
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.77870467
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.77642437
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77482162
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.77475664
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.77390596
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77091248
148* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76791285
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76569420
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76484862
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76445112
152TP53_16413492_ChIP-PET_HCT116_Human0.76295451
153SOX2_19829295_ChIP-Seq_ESCs_Human0.76128776
154NANOG_19829295_ChIP-Seq_ESCs_Human0.76128776
155AHR_22903824_ChIP-Seq_MCF-7_Human0.76014789
156RNF2_27304074_Chip-Seq_ESCs_Mouse0.75915165
157ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75799188
158THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75724588
159KDM2B_26808549_Chip-Seq_REH_Human0.75431651
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75422171
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75228570
162CBP_21632823_ChIP-Seq_H3396_Human0.74232537
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.73386944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.68761512
2MP0005360_urolithiasis5.98701497
3MP0005085_abnormal_gallbladder_physiolo5.12585932
4MP0005365_abnormal_bile_salt4.70933119
5MP0008875_abnormal_xenobiotic_pharmacok4.23979680
6MP0003806_abnormal_nucleotide_metabolis4.03416380
7MP0000569_abnormal_digit_pigmentation3.08407712
8MP0003195_calcinosis3.04581837
9MP0000920_abnormal_myelination3.02496291
10MP0003436_decreased_susceptibility_to2.86968679
11MP0003252_abnormal_bile_duct2.85729674
12MP0003303_peritoneal_inflammation2.83366418
13MP0009840_abnormal_foam_cell2.81006594
14MP0010329_abnormal_lipoprotein_level2.60739539
15MP0005083_abnormal_biliary_tract2.47822385
16MP0003690_abnormal_glial_cell2.41117561
17MP0001835_abnormal_antigen_presentation2.40710777
18MP0002419_abnormal_innate_immunity2.40253013
19MP0005332_abnormal_amino_acid2.27776479
20MP0006054_spinal_hemorrhage2.27108804
21MP0009785_altered_susceptibility_to2.17687483
22MP0005164_abnormal_response_to2.16208507
23MP0003329_amyloid_beta_deposits2.15023448
24MP0001666_abnormal_nutrient_absorption2.12918027
25MP0003300_gastrointestinal_ulcer2.11504554
26MP0003183_abnormal_peptide_metabolism2.01820726
27MP0002118_abnormal_lipid_homeostasis1.93707922
28MP0002148_abnormal_hypersensitivity_rea1.91293741
29MP0005025_abnormal_response_to1.89659569
30MP0005451_abnormal_body_composition1.85661221
31MP0004883_abnormal_blood_vessel1.83982933
32MP0001800_abnormal_humoral_immune1.78646258
33MP0005000_abnormal_immune_tolerance1.78156605
34MP0000604_amyloidosis1.78126019
35MP0001790_abnormal_immune_system1.77846736
36MP0005387_immune_system_phenotype1.77846736
37MP0003045_fibrosis1.76999949
38MP0005464_abnormal_platelet_physiology1.75217013
39MP0003950_abnormal_plasma_membrane1.73575439
40MP0003880_abnormal_central_pattern1.71110225
41MP0000685_abnormal_immune_system1.71055057
42MP0003868_abnormal_feces_composition1.65917878
43MP0001533_abnormal_skeleton_physiology1.65536631
44* MP0002723_abnormal_immune_serum1.65457531
45MP0003828_pulmonary_edema1.64501869
46MP0005671_abnormal_response_to1.62653172
47MP0002452_abnormal_antigen_presenting1.60391738
48MP0004947_skin_inflammation1.59906457
49MP0003172_abnormal_lysosome_physiology1.55400487
50MP0005409_darkened_coat_color1.54633198
51MP0003191_abnormal_cellular_cholesterol1.54412748
52MP0001851_eye_inflammation1.50630833
53MP0005584_abnormal_enzyme/coenzyme_acti1.48505103
54MP0004381_abnormal_hair_follicle1.46104216
55MP0000609_abnormal_liver_physiology1.45105125
56MP0002420_abnormal_adaptive_immunity1.42000412
57MP0002405_respiratory_system_inflammati1.41716652
58MP0001819_abnormal_immune_cell1.40833816
59MP0008057_abnormal_DNA_replication1.35229535
60MP0004019_abnormal_vitamin_homeostasis1.33118378
61MP0004270_analgesia1.31320682
62MP0002168_other_aberrant_phenotype1.31176867
63MP0004142_abnormal_muscle_tone1.29025628
64MP0003566_abnormal_cell_adhesion1.27428981
65MP0005023_abnormal_wound_healing1.27421400
66MP0003656_abnormal_erythrocyte_physiolo1.27080276
67MP0003453_abnormal_keratinocyte_physiol1.24175449
68MP0003011_delayed_dark_adaptation1.22359048
69MP0001845_abnormal_inflammatory_respons1.20760869
70MP0001661_extended_life_span1.18568648
71MP0004885_abnormal_endolymph1.17969179
72MP0005310_abnormal_salivary_gland1.17403574
73MP0003632_abnormal_nervous_system1.17248069
74MP0005397_hematopoietic_system_phenotyp1.17111899
75MP0001545_abnormal_hematopoietic_system1.17111899
76MP0000015_abnormal_ear_pigmentation1.16889293
77MP0000371_diluted_coat_color1.16287618
78MP0010155_abnormal_intestine_physiology1.14729824
79MP0005319_abnormal_enzyme/_coenzyme1.11575286
80MP0005408_hypopigmentation1.11026010
81MP0002332_abnormal_exercise_endurance1.10949476
82MP0001764_abnormal_homeostasis1.09665879
83MP0001905_abnormal_dopamine_level1.07456467
84MP0009697_abnormal_copulation1.06494709
85MP0005275_abnormal_skin_tensile1.06312239
86MP0003634_abnormal_glial_cell1.05561214
87MP0002998_abnormal_bone_remodeling1.04916863
88MP0005174_abnormal_tail_pigmentation1.04910684
89MP0000465_gastrointestinal_hemorrhage1.04424582
90MP0002272_abnormal_nervous_system1.03891265
91MP0001529_abnormal_vocalization1.02823852
92MP0000858_altered_metastatic_potential1.02724577
93MP0002064_seizures1.02094375
94MP0001216_abnormal_epidermal_layer1.01113764
95MP0001486_abnormal_startle_reflex1.00801970
96MP0004484_altered_response_of0.99366267
97MP0000716_abnormal_immune_system0.98838528
98MP0002138_abnormal_hepatobiliary_system0.98807154
99MP0005166_decreased_susceptibility_to0.98233363
100MP0005167_abnormal_blood-brain_barrier0.97655449
101MP0003091_abnormal_cell_migration0.97288467
102MP0005171_absent_coat_pigmentation0.97121639
103MP0010678_abnormal_skin_adnexa0.94434552
104MP0003136_yellow_coat_color0.94344349
105MP0004742_abnormal_vestibular_system0.93338818
106MP0003631_nervous_system_phenotype0.93176328
107MP0010234_abnormal_vibrissa_follicle0.92919002
108MP0000427_abnormal_hair_cycle0.92603553
109MP0000249_abnormal_blood_vessel0.92073718
110MP0003448_altered_tumor_morphology0.92047645
111MP0002822_catalepsy0.91990615
112MP0001853_heart_inflammation0.91251470
113MP0002229_neurodegeneration0.90757057
114MP0004043_abnormal_pH_regulation0.88945267
115MP0005647_abnormal_sex_gland0.88854357
116MP0002396_abnormal_hematopoietic_system0.87570641
117MP0001915_intracranial_hemorrhage0.86558766
118MP0003633_abnormal_nervous_system0.86357405
119MP0003763_abnormal_thymus_physiology0.86054608
120MP0004859_abnormal_synaptic_plasticity0.86053529
121MP0006082_CNS_inflammation0.84602933
122MP0009745_abnormal_behavioral_response0.84292614
123MP0009278_abnormal_bone_marrow0.80412893
124MP0009765_abnormal_xenobiotic_induced0.80260811
125MP0000579_abnormal_nail_morphology0.79807788
126MP0003075_altered_response_to0.78530397
127MP0002398_abnormal_bone_marrow0.78234435
128MP0009384_cardiac_valve_regurgitation0.78211106
129MP0003186_abnormal_redox_activity0.77666818
130MP0002132_abnormal_respiratory_system0.77548776
131MP0005410_abnormal_fertilization0.77054765
132MP0009763_increased_sensitivity_to0.76738433
133MP0008438_abnormal_cutaneous_collagen0.76020106
134* MP0002060_abnormal_skin_morphology0.75656383
135MP0005075_abnormal_melanosome_morpholog0.73733512
136MP0000639_abnormal_adrenal_gland0.73019038
137MP0005551_abnormal_eye_electrophysiolog0.72539044
138MP0000383_abnormal_hair_follicle0.70979269
139MP0009643_abnormal_urine_homeostasis0.70418505
140MP0004147_increased_porphyrin_level0.68699065
141MP0000462_abnormal_digestive_system0.68411103
142MP0002295_abnormal_pulmonary_circulatio0.67008923
143MP0008874_decreased_physiological_sensi0.67007720
144MP0009764_decreased_sensitivity_to0.66929234
145MP0003635_abnormal_synaptic_transmissio0.66745353
146MP0005636_abnormal_mineral_homeostasis0.66173313
147MP0008260_abnormal_autophagy0.65988509
148MP0005058_abnormal_lysosome_morphology0.64978353
149MP0000778_abnormal_nervous_system0.64863879
150MP0005535_abnormal_body_temperature0.64861039
151MP0002090_abnormal_vision0.64517462
152MP0000647_abnormal_sebaceous_gland0.64499242
153MP0002876_abnormal_thyroid_physiology0.62237229
154MP0000566_synostosis0.60274367
155MP0001440_abnormal_grooming_behavior0.58872419
156MP0009046_muscle_twitch0.58815665
157MP0003724_increased_susceptibility_to0.57687490
158MP0002572_abnormal_emotion/affect_behav0.57486596
159MP0001177_atelectasis0.57129748
160MP0000598_abnormal_liver_morphology0.56111888
161MP0005376_homeostasis/metabolism_phenot0.55804680
162MP0001485_abnormal_pinna_reflex0.55020517
163MP0009642_abnormal_blood_homeostasis0.52890933
164MP0002063_abnormal_learning/memory/cond0.52142926
165MP0008469_abnormal_protein_level0.51989326
166MP0001346_abnormal_lacrimal_gland0.48698311
167MP0002066_abnormal_motor_capabilities/c0.47689469
168MP0000467_abnormal_esophagus_morphology0.47069103
169MP0002971_abnormal_brown_adipose0.47068648

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.64769137
2Intrahepatic cholestasis (HP:0001406)6.63664166
3Deep venous thrombosis (HP:0002625)6.05614921
4Prolonged partial thromboplastin time (HP:0003645)5.50027672
5Xanthomatosis (HP:0000991)5.15821063
6Hypobetalipoproteinemia (HP:0003563)5.01189412
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.89158661
8Hyperlipoproteinemia (HP:0010980)4.87720804
9Orchitis (HP:0100796)4.59515387
10Retrobulbar optic neuritis (HP:0100654)4.46543737
11Optic neuritis (HP:0100653)4.46543737
12Complement deficiency (HP:0004431)4.35204046
13Neurofibrillary tangles (HP:0002185)4.30955433
14Myositis (HP:0100614)4.24915403
15Thick nail (HP:0001805)4.20390926
16Recurrent bacterial skin infections (HP:0005406)4.12604247
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.89842150
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.89842150
19Abnormality of methionine metabolism (HP:0010901)3.88760248
20Epidermoid cyst (HP:0200040)3.75835637
21Fat malabsorption (HP:0002630)3.67566744
22Recurrent abscess formation (HP:0002722)3.66806076
23Keratoconjunctivitis sicca (HP:0001097)3.60168480
24Milia (HP:0001056)3.58330095
25Joint hemorrhage (HP:0005261)3.55076117
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53912976
27Eczematoid dermatitis (HP:0000976)3.46223424
28Keratoconjunctivitis (HP:0001096)3.44734318
29Hypolipoproteinemia (HP:0010981)3.43384357
30Plantar hyperkeratosis (HP:0007556)3.40111098
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38907643
32Abnormality of the common coagulation pathway (HP:0010990)3.38101171
33Hyperammonemia (HP:0001987)3.35782612
34Conjugated hyperbilirubinemia (HP:0002908)3.31643794
35Cerebral inclusion bodies (HP:0100314)3.26466182
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.23093942
37Hyperglycinemia (HP:0002154)3.22122404
38Abnormality of the corticospinal tract (HP:0002492)3.19669644
39Onycholysis (HP:0001806)3.17146016
40Ketosis (HP:0001946)3.13537027
41Stomatitis (HP:0010280)3.11608539
42Abnormality of nail color (HP:0100643)3.09391729
43Elevated erythrocyte sedimentation rate (HP:0003565)3.09304243
44Steatorrhea (HP:0002570)3.08490011
45Abnormality of serine family amino acid metabolism (HP:0010894)3.05781058
46Abnormality of glycine metabolism (HP:0010895)3.05781058
47Abnormality of macrophages (HP:0004311)3.01774813
48Alopecia of scalp (HP:0002293)3.00646271
49Congenital sensorineural hearing impairment (HP:0008527)2.99604686
50Recurrent skin infections (HP:0001581)2.98965850
51Gangrene (HP:0100758)2.95687660
52Parakeratosis (HP:0001036)2.94434843
53Abnormality of complement system (HP:0005339)2.93052117
54Gastrointestinal infarctions (HP:0005244)2.82804377
55Peritonitis (HP:0002586)2.75272179
56Hypoalphalipoproteinemia (HP:0003233)2.73243214
57Sensory axonal neuropathy (HP:0003390)2.69554607
58Recurrent fungal infections (HP:0002841)2.67153390
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67076134
60Chronic mucocutaneous candidiasis (HP:0002728)2.66967199
61Recurrent cutaneous fungal infections (HP:0011370)2.66967199
62Hypercholesterolemia (HP:0003124)2.64266022
63Fragile nails (HP:0001808)2.63961505
64Palmoplantar hyperkeratosis (HP:0000972)2.63799911
65Arterial thrombosis (HP:0004420)2.63634324
66Cholecystitis (HP:0001082)2.61258141
67Abnormal gallbladder physiology (HP:0012438)2.61258141
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61242954
69Amyloidosis (HP:0011034)2.61215736
70Gingivitis (HP:0000230)2.59888808
71Subacute progressive viral hepatitis (HP:0006572)2.55878027
72Hemoptysis (HP:0002105)2.54958141
73Spastic paraparesis (HP:0002313)2.53339953
74Hypophosphatemic rickets (HP:0004912)2.52528522
75Pulmonary infiltrates (HP:0002113)2.52140957
76Glomerulonephritis (HP:0000099)2.51355810
77Fair hair (HP:0002286)2.50200329
78Vascular calcification (HP:0004934)2.49392561
79Abnormality of the intrinsic pathway (HP:0010989)2.47278037
80Spontaneous abortion (HP:0005268)2.47073290
81Pulmonary embolism (HP:0002204)2.46823764
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45963789
83Epistaxis (HP:0000421)2.45403255
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.44572032
85Pustule (HP:0200039)2.42967227
86Palmar hyperkeratosis (HP:0010765)2.42743510
87Urticaria (HP:0001025)2.41622326
88Hyperbilirubinemia (HP:0002904)2.40832641
89Acanthocytosis (HP:0001927)2.40648063
90Atrophic scars (HP:0001075)2.40197276
91Cheilitis (HP:0100825)2.39274363
92Cerebral hemorrhage (HP:0001342)2.35747351
93Periodontitis (HP:0000704)2.35263368
94Abnormal gallbladder morphology (HP:0012437)2.33661199
95Abnormality of fatty-acid metabolism (HP:0004359)2.33422170
96Episodic fever (HP:0001954)2.31863351
97Delayed CNS myelination (HP:0002188)2.31841523
98Abnormality of serum amino acid levels (HP:0003112)2.28592442
99Vasculitis (HP:0002633)2.27863641
100Spastic gait (HP:0002064)2.27501908
101Insidious onset (HP:0003587)2.27129889
102Termporal pattern (HP:0011008)2.27129889
103Hypoglycemic coma (HP:0001325)2.27030050
104Generalized hypopigmentation of hair (HP:0011358)2.26459990
105Abnormality of T cell number (HP:0011839)2.26264193
106Hyperglycinuria (HP:0003108)2.25619543
107Onion bulb formation (HP:0003383)2.24820065
108Increased cerebral lipofuscin (HP:0011813)2.24525012
109Cardiovascular calcification (HP:0011915)2.24277653
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.22323368
111Intention tremor (HP:0002080)2.21272706
112Skin nodule (HP:0200036)2.18984481
113Mediastinal lymphadenopathy (HP:0100721)2.18845282
114Abnormality of the axillary hair (HP:0100134)2.18405269
115Abnormality of secondary sexual hair (HP:0009888)2.18405269
116Blue irides (HP:0000635)2.18315517
117Increased IgE level (HP:0003212)2.17471548
118Abnormality of glycolysis (HP:0004366)2.17408509
119Increased serum pyruvate (HP:0003542)2.17408509
120Axonal loss (HP:0003447)2.17372136
121Confusion (HP:0001289)2.14122553
122Cerebral edema (HP:0002181)2.13355665
123Hypochromic microcytic anemia (HP:0004840)2.12859736
124Hypoplastic labia majora (HP:0000059)2.12806100
125Encephalitis (HP:0002383)2.12264173
126Abnormality of glycolipid metabolism (HP:0010969)2.10425807
127Abnormality of liposaccharide metabolism (HP:0010968)2.10425807
128Abnormality of glycosphingolipid metabolism (HP:0004343)2.10425807
129Mitral stenosis (HP:0001718)2.10355467
130Methylmalonic acidemia (HP:0002912)2.09780610
131T lymphocytopenia (HP:0005403)2.09322786
132Abnormal blistering of the skin (HP:0008066)2.08617870
133Metabolic acidosis (HP:0001942)2.08283126
134Scanning speech (HP:0002168)2.07782533
135Cholelithiasis (HP:0001081)2.07456951
136Spontaneous hematomas (HP:0007420)2.07221288
137Meningitis (HP:0001287)2.05218648
138Lower limb hyperreflexia (HP:0002395)2.04017334
139Systemic lupus erythematosus (HP:0002725)2.03917317
140Myocardial infarction (HP:0001658)2.03522834
141Chest pain (HP:0100749)2.01869733
142Rickets (HP:0002748)2.01707092
143Paraparesis (HP:0002385)2.01360540
144Opisthotonus (HP:0002179)2.01334808
145Prolonged bleeding time (HP:0003010)1.99900261
146Thrombophlebitis (HP:0004418)1.99645969
147Spastic tetraparesis (HP:0001285)1.98604561
148Irritability (HP:0000737)1.98533153
149Lethargy (HP:0001254)1.97412880
150Widely spaced teeth (HP:0000687)1.97036004
151Nephritis (HP:0000123)1.96671980
152Hyperventilation (HP:0002883)1.96123783
153Peripheral hypomyelination (HP:0007182)1.95731592
154Leukocytosis (HP:0001974)1.94937079
155Pruritus (HP:0000989)1.94375246
156Anorexia (HP:0002039)1.94293974
157Ketoacidosis (HP:0001993)1.92888743
158Abnormality of the labia majora (HP:0012881)1.92572961
159Peripheral demyelination (HP:0011096)1.92422593
160Dysmetria (HP:0001310)1.92175480
161Abnormality of vitamin metabolism (HP:0100508)1.89691948
162Abnormality of pyrimidine metabolism (HP:0004353)1.89635249
163Choroideremia (HP:0001139)1.88895077
164Eosinophilia (HP:0001880)1.88716740
165Abnormality of the gallbladder (HP:0005264)1.87943382
166Dicarboxylic aciduria (HP:0003215)1.87297580
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87297580
168Coronal craniosynostosis (HP:0004440)1.86982790
169Ectropion (HP:0000656)1.86861690
170Hepatocellular carcinoma (HP:0001402)1.86028624
171Viral hepatitis (HP:0006562)1.85368827
172Gingival bleeding (HP:0000225)1.85266738
173Nail dystrophy (HP:0008404)1.85248473
174Keratitis (HP:0000491)1.83900595
175Abnormality of the pleura (HP:0002103)1.83765236
176Infantile muscular hypotonia (HP:0008947)1.83629084
177Vacuolated lymphocytes (HP:0001922)1.83309280
178Brushfield spots (HP:0001088)1.83255180
179Stomach cancer (HP:0012126)1.82831145
180Supranuclear gaze palsy (HP:0000605)1.82325951
181Morphological abnormality of the pyramidal tract (HP:0002062)1.78515455
182Alkalosis (HP:0001948)1.78288393
183Turricephaly (HP:0000262)1.77303185
184Recurrent gram-negative bacterial infections (HP:0005420)1.77287903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.15918482
2FRK4.74872730
3OXSR13.77876943
4EPHB13.67453097
5BLK3.08054551
6FGFR22.74237885
7PKN12.61356893
8MAP3K22.50735759
9PBK2.49340082
10MAP3K32.40691103
11BCKDK2.40229525
12ERBB42.38827887
13MET2.19102407
14RIPK42.17524019
15EPHA42.06409307
16IRAK42.03529958
17TYK22.03240242
18BCR2.02639061
19SIK12.02516463
20MAP2K31.98518412
21TXK1.96158671
22TNIK1.90224716
23TGFBR21.85211823
24MAPKAPK51.82063627
25WNK41.68783321
26CASK1.68264916
27NTRK11.65206660
28JAK11.64720113
29ZAP701.59533616
30FGFR31.59228363
31CAMK2B1.57148176
32INSRR1.52162175
33CDK191.50177762
34FGFR41.39119956
35FGR1.35506155
36CSNK1G31.34479432
37BMPR21.34299844
38JAK31.33190518
39CSNK1A1L1.32143272
40MAP4K11.31468140
41IKBKE1.30963744
42FER1.30528190
43TESK21.30485851
44HCK1.29346565
45CSF1R1.26341531
46SGK4941.26281229
47SGK2231.26281229
48CAMK2G1.26050531
49JAK21.24593920
50CSNK1G21.23363408
51MAP3K131.21872432
52CSNK1G11.21719708
53MAP3K11.20561293
54KIT1.19429932
55IKBKB1.16931631
56WNK11.16836959
57MAP3K61.16342743
58ICK1.15886683
59SYK1.14094899
60PRPF4B1.13944986
61TAOK31.12128765
62CAMK2D1.12076443
63MATK1.07403500
64RAF11.04816666
65DAPK21.03903037
66LYN1.01720003
67MAPK151.01619102
68BTK1.01572122
69TNK21.01422834
70PRKCQ1.01276697
71GRK71.00929958
72YES11.00267305
73MAP2K41.00161148
74TEC0.98872515
75PDGFRB0.97857611
76GRK60.97328801
77PAK60.96751899
78PAK30.96321257
79TBK10.94607058
80CAMK2A0.94593438
81ROCK20.92508350
82MST1R0.92274650
83SGK30.91628391
84PDK20.87696123
85NTRK30.86468020
86TYRO30.86352231
87STK100.86230987
88NEK60.84169339
89PIK3CG0.84138444
90IRAK20.82404169
91LIMK10.82152455
92SGK20.82093023
93UHMK10.80859916
94ABL20.80394153
95LATS10.79663511
96LCK0.79590259
97ITK0.78816141
98PDPK10.78677894
99MARK20.78575519
100CLK10.77322461
101FES0.76046032
102ACVR1B0.75779217
103GSK3A0.75771872
104ADRBK20.75739087
105AKT30.73786715
106STK240.73387252
107ERN10.71978802
108ADRBK10.70993961
109MARK30.68690471
110CDK120.67077278
111MAP3K70.66895548
112STK38L0.66282310
113STK380.65583249
114IRAK10.65498665
115CDK50.62861743
116CAMKK20.62489872
117IRAK30.62171917
118KSR20.62030768
119CSK0.61585451
120PRKD10.61325710
121FLT30.59463444
122ABL10.58883713
123ERBB20.58759049
124PRKCE0.58438675
125CHUK0.58243338
126PDGFRA0.56738457
127PIK3CA0.56606236
128MAPK70.56404386
129PNCK0.56103138
130FYN0.55590399
131TGFBR10.53883423
132NEK90.51015729
133NLK0.50896860
134PRKCZ0.50402477
135SIK30.49727216
136MAP3K50.49695756
137ARAF0.49657583
138MUSK0.49610367
139MARK10.48971771
140MOS0.48409927
141PTK2B0.48187669
142PRKAA20.46946470
143MAPK40.46454111
144PRKG10.46449676
145PINK10.46190285
146RIPK10.46166641
147PRKCH0.46094995
148CDK140.45470943
149PRKACB0.44897399
150MAPK110.44592279
151PTK20.44310780
152CDK150.43603251
153MAPK120.43357363
154PDK10.42684835
155EPHA30.42449086
156CAMK1G0.41982154
157BMX0.41961333
158IGF1R0.41895373
159CDC42BPA0.41000778
160DYRK20.39134726
161PRKCG0.38756342
162RET0.38694824
163CDK180.38034413
164CSNK1D0.37405622
165NTRK20.37236541
166MAP3K140.37090235
167TRPM70.36500243
168GRK10.36361731

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.16691068
2Nitrogen metabolism_Homo sapiens_hsa009103.73447371
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.24676105
4Steroid biosynthesis_Homo sapiens_hsa001002.79382538
5Fatty acid elongation_Homo sapiens_hsa000622.73455449
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62388031
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61688845
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56831923
9Arginine biosynthesis_Homo sapiens_hsa002202.55347315
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51054588
11Complement and coagulation cascades_Homo sapiens_hsa046102.40617799
12Histidine metabolism_Homo sapiens_hsa003402.34145017
13Butanoate metabolism_Homo sapiens_hsa006502.33432413
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21849171
15Tryptophan metabolism_Homo sapiens_hsa003802.19319695
16Leishmaniasis_Homo sapiens_hsa051402.15836792
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15270641
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10010186
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08965543
20Osteoclast differentiation_Homo sapiens_hsa043802.06632472
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.96793806
22Peroxisome_Homo sapiens_hsa041461.95035298
23Fatty acid degradation_Homo sapiens_hsa000711.92730905
24Sulfur metabolism_Homo sapiens_hsa009201.91416047
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82888332
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76838466
27Chemical carcinogenesis_Homo sapiens_hsa052041.76408212
28Propanoate metabolism_Homo sapiens_hsa006401.74518775
29Fatty acid metabolism_Homo sapiens_hsa012121.73257044
30Tuberculosis_Homo sapiens_hsa051521.71567808
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68481705
32Dorso-ventral axis formation_Homo sapiens_hsa043201.67237716
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62359510
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61325008
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60134891
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60105923
37Retinol metabolism_Homo sapiens_hsa008301.60081086
38PPAR signaling pathway_Homo sapiens_hsa033201.55098702
39Toxoplasmosis_Homo sapiens_hsa051451.53487977
40Staphylococcus aureus infection_Homo sapiens_hsa051501.49789052
41beta-Alanine metabolism_Homo sapiens_hsa004101.45568460
42Pertussis_Homo sapiens_hsa051331.45433188
43Vitamin B6 metabolism_Homo sapiens_hsa007501.40608916
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40507116
45Hematopoietic cell lineage_Homo sapiens_hsa046401.39886185
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.38306552
47Legionellosis_Homo sapiens_hsa051341.37805630
48TNF signaling pathway_Homo sapiens_hsa046681.37592953
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.35093106
50Tyrosine metabolism_Homo sapiens_hsa003501.33775933
51Bile secretion_Homo sapiens_hsa049761.33276450
52Graft-versus-host disease_Homo sapiens_hsa053321.32802615
53Amoebiasis_Homo sapiens_hsa051461.31302806
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31071332
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29250761
56Caffeine metabolism_Homo sapiens_hsa002321.26256718
57Phenylalanine metabolism_Homo sapiens_hsa003601.25615945
58Measles_Homo sapiens_hsa051621.24333010
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24008677
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21747717
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21012953
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20087740
63Influenza A_Homo sapiens_hsa051641.15515764
64Arginine and proline metabolism_Homo sapiens_hsa003301.13002012
65B cell receptor signaling pathway_Homo sapiens_hsa046621.12521941
66Pyruvate metabolism_Homo sapiens_hsa006201.11781382
67Other glycan degradation_Homo sapiens_hsa005111.10886292
68Folate biosynthesis_Homo sapiens_hsa007901.09316437
69Allograft rejection_Homo sapiens_hsa053301.07479008
70Platelet activation_Homo sapiens_hsa046111.07433244
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07065661
72ABC transporters_Homo sapiens_hsa020101.06323638
73* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01577053
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.98898487
75Pancreatic cancer_Homo sapiens_hsa052120.98742134
76Acute myeloid leukemia_Homo sapiens_hsa052210.97542922
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.97189755
78Chemokine signaling pathway_Homo sapiens_hsa040620.95629216
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.94881948
80Vitamin digestion and absorption_Homo sapiens_hsa049770.89900922
81Ether lipid metabolism_Homo sapiens_hsa005650.89309882
82Phagosome_Homo sapiens_hsa041450.87785429
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87750890
84Fat digestion and absorption_Homo sapiens_hsa049750.86098239
85T cell receptor signaling pathway_Homo sapiens_hsa046600.85045831
86Autoimmune thyroid disease_Homo sapiens_hsa053200.83506459
87Starch and sucrose metabolism_Homo sapiens_hsa005000.81458576
88Selenocompound metabolism_Homo sapiens_hsa004500.81455998
89Hepatitis C_Homo sapiens_hsa051600.81235583
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81176087
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81057861
92Non-small cell lung cancer_Homo sapiens_hsa052230.77985963
93Small cell lung cancer_Homo sapiens_hsa052220.76680248
94Insulin resistance_Homo sapiens_hsa049310.74931593
95Antigen processing and presentation_Homo sapiens_hsa046120.74740096
96Prolactin signaling pathway_Homo sapiens_hsa049170.74219390
97Hepatitis B_Homo sapiens_hsa051610.72983200
98Rheumatoid arthritis_Homo sapiens_hsa053230.71683442
99FoxO signaling pathway_Homo sapiens_hsa040680.70667079
100ECM-receptor interaction_Homo sapiens_hsa045120.70156295
101VEGF signaling pathway_Homo sapiens_hsa043700.69857830
102Type I diabetes mellitus_Homo sapiens_hsa049400.68123260
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67871838
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.67133304
105Glutathione metabolism_Homo sapiens_hsa004800.66325650
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66175634
107Biosynthesis of amino acids_Homo sapiens_hsa012300.65151922
108Chronic myeloid leukemia_Homo sapiens_hsa052200.64860172
109Prion diseases_Homo sapiens_hsa050200.64650992
110Linoleic acid metabolism_Homo sapiens_hsa005910.64539521
111Renal cell carcinoma_Homo sapiens_hsa052110.64065767
112Salmonella infection_Homo sapiens_hsa051320.63600679
113Asthma_Homo sapiens_hsa053100.62794212
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62499146
115Glycerolipid metabolism_Homo sapiens_hsa005610.62210138
116Fatty acid biosynthesis_Homo sapiens_hsa000610.61563503
117Focal adhesion_Homo sapiens_hsa045100.61228248
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.60629716
119Herpes simplex infection_Homo sapiens_hsa051680.60272882
120Carbon metabolism_Homo sapiens_hsa012000.56556388
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55077346
122Sulfur relay system_Homo sapiens_hsa041220.52828500
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.51873449
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.51510398
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.51219971
126mTOR signaling pathway_Homo sapiens_hsa041500.48863300
127Choline metabolism in cancer_Homo sapiens_hsa052310.48636461
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.48416987
129Metabolic pathways_Homo sapiens_hsa011000.47737499
130ErbB signaling pathway_Homo sapiens_hsa040120.46916239
131Apoptosis_Homo sapiens_hsa042100.46497739
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44220249
133Proteoglycans in cancer_Homo sapiens_hsa052050.43817940
134Type II diabetes mellitus_Homo sapiens_hsa049300.42629871
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42265458
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37055518
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.35978873
138Lysine degradation_Homo sapiens_hsa003100.35172803
139GABAergic synapse_Homo sapiens_hsa047270.31794096
140Sphingolipid metabolism_Homo sapiens_hsa006000.30627824
141Ovarian steroidogenesis_Homo sapiens_hsa049130.22850683
142Axon guidance_Homo sapiens_hsa043600.22302267
143Glutamatergic synapse_Homo sapiens_hsa047240.19659770
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17576237
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14586680
146Pentose phosphate pathway_Homo sapiens_hsa000300.12509452
147Oxidative phosphorylation_Homo sapiens_hsa001900.11485760
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09898072
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.08526957
150Protein export_Homo sapiens_hsa030600.07925485
151Arachidonic acid metabolism_Homo sapiens_hsa005900.07829096
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.06669883
153Cocaine addiction_Homo sapiens_hsa050300.02576360
154Alzheimers disease_Homo sapiens_hsa050100.02167610
155African trypanosomiasis_Homo sapiens_hsa051430.02033478
156Lysosome_Homo sapiens_hsa041420.01641116
157Serotonergic synapse_Homo sapiens_hsa047260.01561836
158Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00090261
159Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0822921
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0681373
161Morphine addiction_Homo sapiens_hsa05032-0.0478137
162Mineral absorption_Homo sapiens_hsa04978-0.0459088
163Regulation of autophagy_Homo sapiens_hsa04140-0.0434831
164Long-term depression_Homo sapiens_hsa04730-0.0415477
165Malaria_Homo sapiens_hsa05144-0.0328499
166Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0273887
167Nicotine addiction_Homo sapiens_hsa05033-0.0145815
168Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0133300

Most similar genes based on co-expression Upload to Enrichr

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