IL1RL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of endothelial cell differentiation (GO:0045601)9.90706119
2response to follicle-stimulating hormone (GO:0032354)8.70757862
3hemoglobin metabolic process (GO:0020027)7.92611986
4eyelid development in camera-type eye (GO:0061029)7.23964853
5positive regulation of mitotic sister chromatid separation (GO:1901970)7.07883637
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)7.07883637
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)7.07883637
8chondrocyte proliferation (GO:0035988)6.85688680
9cellular response to cholesterol (GO:0071397)6.68202369
10regulation of macrophage differentiation (GO:0045649)6.65706949
11negative regulation of axon extension involved in axon guidance (GO:0048843)6.57393714
12cellular response to sterol (GO:0036315)6.57012907
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.47209961
14positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)6.36259982
15sequestering of extracellular ligand from receptor (GO:0035581)5.95787717
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.79821141
17positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)5.70847059
18collagen fibril organization (GO:0030199)5.30190728
19negative regulation of complement activation (GO:0045916)5.21663623
20negative regulation of leukocyte chemotaxis (GO:0002689)5.19947247
21negative regulation of axon guidance (GO:1902668)5.14735000
22activin receptor signaling pathway (GO:0032924)5.12663866
23cellular response to gonadotropin stimulus (GO:0071371)5.05872328
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.97207920
25mesenchymal-epithelial cell signaling (GO:0060638)4.95994118
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.95775858
27regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)4.95681649
28regulation of interferon-gamma biosynthetic process (GO:0045072)4.92812383
29response to sterol (GO:0036314)4.87638779
30tyrosine phosphorylation of STAT protein (GO:0007260)4.86877016
31response to cholesterol (GO:0070723)4.69505810
32negative regulation of Ras GTPase activity (GO:0034261)4.68925031
33negative regulation of protein activation cascade (GO:2000258)4.63905028
34regulation of endothelial cell chemotaxis (GO:2001026)4.62130717
35positive regulation of actin filament depolymerization (GO:0030836)4.60090677
36L-serine transport (GO:0015825)4.45694384
37neuron projection extension involved in neuron projection guidance (GO:1902284)4.44133894
38axon extension involved in axon guidance (GO:0048846)4.44133894
39positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)4.39661325
40macroautophagy (GO:0016236)4.38747637
41* positive regulation of macrophage activation (GO:0043032)4.37097175
42establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)4.30897340
43protein localization to cell surface (GO:0034394)4.30886887
44skin morphogenesis (GO:0043589)4.26261246
45regulation of axon extension involved in axon guidance (GO:0048841)4.25437155
46plasma membrane repair (GO:0001778)4.09849868
47cellular response to interleukin-4 (GO:0071353)4.05947017
48positive regulation of chromosome segregation (GO:0051984)4.03841685
49heterochromatin organization (GO:0070828)4.01397849
50polyamine biosynthetic process (GO:0006596)4.00180093
51negative regulation of humoral immune response (GO:0002921)3.99874036
52positive regulation of erythrocyte differentiation (GO:0045648)3.95993690
53cell adhesion mediated by integrin (GO:0033627)3.95823807
54endodermal cell differentiation (GO:0035987)3.93422128
55negative regulation of fatty acid transport (GO:2000192)3.93342819
56response to gonadotropin (GO:0034698)3.90032572
57chondroitin sulfate biosynthetic process (GO:0030206)3.84477469
58protein heterotrimerization (GO:0070208)3.83771856
59cellular response to interferon-alpha (GO:0035457)3.78997400
60* negative regulation of interferon-gamma production (GO:0032689)3.78972718
61hepatocyte apoptotic process (GO:0097284)3.78905524
62cellular biogenic amine catabolic process (GO:0042402)3.77587919
63amine catabolic process (GO:0009310)3.77587919
64serine transport (GO:0032329)3.77135853
65positive regulation of receptor recycling (GO:0001921)3.71745901
66negative regulation of Rho protein signal transduction (GO:0035024)3.70415111
67positive regulation of catenin import into nucleus (GO:0035413)3.66068436
68negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.62854554
69glycoprotein catabolic process (GO:0006516)3.61564544
70regulation of axon guidance (GO:1902667)3.60417582
71histone-serine phosphorylation (GO:0035404)3.56266981
72regulation of B cell differentiation (GO:0045577)3.55962681
73wound healing, spreading of epidermal cells (GO:0035313)3.48786970
74cell migration involved in sprouting angiogenesis (GO:0002042)3.48510661
75dermatan sulfate biosynthetic process (GO:0030208)3.47290446
76positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.47119133
77apoptotic cell clearance (GO:0043277)3.43462554
78positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.42815115
79vascular smooth muscle contraction (GO:0014829)3.42044289
80negative regulation of endothelial cell apoptotic process (GO:2000352)3.38017274
81positive regulation of endothelial cell apoptotic process (GO:2000353)3.35154208
82peptidyl-proline hydroxylation (GO:0019511)3.33449711
83regulation of integrin-mediated signaling pathway (GO:2001044)3.32338648
84regulation of membrane protein ectodomain proteolysis (GO:0051043)3.29631610
85regulation of monocyte chemotaxis (GO:0090025)3.28187618
86regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.27473465
87response to interleukin-4 (GO:0070670)3.25711614
88regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.23865520
89endothelial cell proliferation (GO:0001935)3.22279603
90wound healing (GO:0042060)3.18254060
91positive regulation of reproductive process (GO:2000243)3.17474625
92blood vessel maturation (GO:0001955)3.16426323
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15751142
94wound healing, spreading of cells (GO:0044319)3.15415266
95retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14278765
96histamine secretion (GO:0001821)3.13979444
97dermatan sulfate metabolic process (GO:0030205)3.12083496
98positive regulation of macrophage differentiation (GO:0045651)3.11103876
99positive regulation of odontogenesis (GO:0042482)3.10273778
100collagen metabolic process (GO:0032963)3.08964386
101protein hydroxylation (GO:0018126)3.07568858
102regulation of cell aging (GO:0090342)3.07335772
103regulation of hippo signaling (GO:0035330)3.03719039
104decidualization (GO:0046697)3.03211805
105cGMP-mediated signaling (GO:0019934)3.02886745
106regulation of mitotic spindle organization (GO:0060236)3.02339353
107positive regulation of mast cell degranulation (GO:0043306)3.01197952
108positive regulation of mast cell activation involved in immune response (GO:0033008)3.01197952
109positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.00606758
110artery smooth muscle contraction (GO:0014824)3.00465506
111negative regulation of chondrocyte differentiation (GO:0032331)3.00183175
112extracellular regulation of signal transduction (GO:1900115)2.99360757
113extracellular negative regulation of signal transduction (GO:1900116)2.99360757
114regulation of endocrine process (GO:0044060)2.99131645
115positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99010673
116regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.98049584
117platelet aggregation (GO:0070527)2.97930740
118regulation of cellular senescence (GO:2000772)2.97159797
119regulation of penile erection (GO:0060405)2.96816259
120regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.96431544
121ganglion development (GO:0061548)2.95801773
122cellular response to ATP (GO:0071318)2.95423317
123collagen catabolic process (GO:0030574)2.95340546
124regulation of chemokine-mediated signaling pathway (GO:0070099)2.94458194
125positive regulation of natural killer cell differentiation (GO:0032825)2.94167998
126positive regulation of leukocyte degranulation (GO:0043302)2.92495607
127heart trabecula formation (GO:0060347)2.91250841
128mesodermal cell differentiation (GO:0048333)2.89988620
129extracellular matrix disassembly (GO:0022617)2.89255194
130nuclear pore complex assembly (GO:0051292)2.89049153
131mRNA transcription (GO:0009299)2.87908660
132regulation of podosome assembly (GO:0071801)2.87074939
133positive regulation of endothelial cell migration (GO:0010595)2.86468402
134nerve growth factor signaling pathway (GO:0038180)2.86045754
135positive regulation of angiogenesis (GO:0045766)2.85791043
136positive regulation of astrocyte differentiation (GO:0048711)2.85400232
137germ cell migration (GO:0008354)2.84327086
138regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.84257368
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.83993090
140response to fluid shear stress (GO:0034405)2.83034594
141positive regulation of fibroblast migration (GO:0010763)2.82712703
142positive regulation of JAK-STAT cascade (GO:0046427)2.82700372
143positive regulation of urine volume (GO:0035810)2.82430134
144multicellular organismal macromolecule metabolic process (GO:0044259)2.82153852
145angiotensin maturation (GO:0002003)2.82012646
146maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81871413
147substrate adhesion-dependent cell spreading (GO:0034446)2.81655522
148negative regulation of B cell proliferation (GO:0030889)2.81277806
149lipoprotein metabolic process (GO:0042157)2.79669272
150positive regulation vascular endothelial growth factor production (GO:0010575)2.78310832
151DNA integration (GO:0015074)2.78033904
152endothelium development (GO:0003158)2.77608274
153blood vessel endothelial cell migration (GO:0043534)2.75789952
154mitotic G2 DNA damage checkpoint (GO:0007095)2.75311066
155positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.74440532
156lymphangiogenesis (GO:0001946)2.74423397
157negative regulation of DNA repair (GO:0045738)2.74398864
158chondrocyte development (GO:0002063)2.74294154
159establishment or maintenance of bipolar cell polarity (GO:0061245)2.74031629
160establishment or maintenance of apical/basal cell polarity (GO:0035088)2.74031629
161behavioral response to ethanol (GO:0048149)2.73800021
162negative regulation of bone mineralization (GO:0030502)2.73027436
163regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72835445
164positive regulation of osteoblast proliferation (GO:0033690)2.72641066
165positive regulation of endothelial cell proliferation (GO:0001938)2.72572100
166positive regulation of axon extension (GO:0045773)2.71032171
167negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.70917756
168patterning of blood vessels (GO:0001569)2.70231555
169epithelial cell-cell adhesion (GO:0090136)2.69012865
170regulation of tight junction assembly (GO:2000810)2.69000009
171pore complex assembly (GO:0046931)2.67535379
172negative regulation of smooth muscle cell differentiation (GO:0051151)2.66317294
173cellular response to vitamin D (GO:0071305)2.65469205
174multicellular organismal metabolic process (GO:0044236)2.64026576
175negative chemotaxis (GO:0050919)2.63839323
176multicellular organismal catabolic process (GO:0044243)2.62827574
177tonic smooth muscle contraction (GO:0014820)2.62826632
178protein localization to endosome (GO:0036010)2.61616798
179production of molecular mediator involved in inflammatory response (GO:0002532)2.60256717
180COPI coating of Golgi vesicle (GO:0048205)2.60135725
181Golgi transport vesicle coating (GO:0048200)2.60135725
182hippo signaling (GO:0035329)2.60039164
183negative regulation of bone remodeling (GO:0046851)2.59043766
184cellular response to amino acid stimulus (GO:0071230)2.58613697
185nuclear pore organization (GO:0006999)2.56657985
186protein retention in ER lumen (GO:0006621)2.56561589
187positive regulation of Rho protein signal transduction (GO:0035025)2.56480277
188cortical actin cytoskeleton organization (GO:0030866)2.56141874
189regulation of hypersensitivity (GO:0002883)2.55808235
190regulation of gonadotropin secretion (GO:0032276)11.6334691
191negative regulation of macrophage differentiation (GO:0045650)11.1632216
192cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.9298587
193endocrine hormone secretion (GO:0060986)10.0210467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.17452672
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.96110144
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.43425533
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.13858603
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.96206948
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91274661
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88049285
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.85046513
9E2F7_22180533_ChIP-Seq_HELA_Human3.83215448
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.82457876
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.64495083
12RBPJ_22232070_ChIP-Seq_NCS_Mouse3.48456609
13TP63_17297297_ChIP-ChIP_HaCaT_Human3.28774719
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10084716
15SCL_19346495_ChIP-Seq_HPC-7_Human2.83999449
16* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.81569351
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.80254455
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.69031293
19* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.60964411
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59819918
21VDR_22108803_ChIP-Seq_LS180_Human2.58011621
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.54486928
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51063821
24CLOCK_20551151_ChIP-Seq_293T_Human2.49645594
25BRD4_25478319_ChIP-Seq_HGPS_Human2.46772930
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.42992774
27CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34367521
28GATA1_22025678_ChIP-Seq_K562_Human2.22471717
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15027655
30CJUN_26792858_Chip-Seq_BT549_Human2.13100896
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.10271185
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.10271185
33TCF4_18268006_ChIP-ChIP_LS174T_Human2.09634664
34AR_21909140_ChIP-Seq_LNCAP_Human2.06855242
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00211725
36ZNF274_21170338_ChIP-Seq_K562_Hela1.97786271
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96907975
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91723625
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91589348
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.81516921
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81173269
42* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79319433
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76667378
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.75671610
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75037238
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75037238
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.72771268
48ELK1_19687146_ChIP-ChIP_HELA_Human1.70019649
49TP53_16413492_ChIP-PET_HCT116_Human1.68522097
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65643431
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63645249
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62845707
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60980789
54ATF3_27146783_Chip-Seq_COLON_Human1.60920385
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.60410938
56* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58677571
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57199152
58* SMAD3_21741376_ChIP-Seq_HESCs_Human1.54691460
59TP53_22127205_ChIP-Seq_IMR90_Human1.52412164
60* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50862385
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.49474539
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48822747
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48733404
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.46297918
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46286930
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.46224495
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45080459
68TP53_18474530_ChIP-ChIP_U2OS_Human1.44436577
69TFEB_21752829_ChIP-Seq_HELA_Human1.44398766
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.43773566
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43625826
72SMAD4_21799915_ChIP-Seq_A2780_Human1.42712067
73BCAT_22108803_ChIP-Seq_LS180_Human1.42339927
74* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40742867
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40545854
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39054053
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38933880
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36442962
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36285969
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36194616
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35979373
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.35636074
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34871748
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34853758
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34771893
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33313710
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32181246
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31730244
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29255907
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28455883
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27891433
92* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27667429
93CDX2_22108803_ChIP-Seq_LS180_Human1.25552616
94SOX2_20726797_ChIP-Seq_SW620_Human1.25029749
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24815105
96VDR_24787735_ChIP-Seq_THP-1_Human1.23928425
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.23839415
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23668863
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.22053690
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21825980
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20797093
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20470545
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20333777
104MYB_26560356_Chip-Seq_TH2_Human1.20223388
105ER_23166858_ChIP-Seq_MCF-7_Human1.20020843
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18819545
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17818044
108TP63_23658742_ChIP-Seq_EP156T_Human1.14440035
109* E2F1_21310950_ChIP-Seq_MCF-7_Human1.13914353
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.13656261
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09187698
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.08583526
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08386833
114MYC_22102868_ChIP-Seq_BL_Human1.06322506
115AHR_22903824_ChIP-Seq_MCF-7_Human1.06141099
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05869981
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05567921
118VDR_24763502_ChIP-Seq_THP-1_Human1.05550398
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04755837
120* SMAD3_21741376_ChIP-Seq_EPCs_Human1.03581578
121MAF_26560356_Chip-Seq_TH1_Human1.03348591
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.02900088
123* FLI1_27457419_Chip-Seq_LIVER_Mouse1.02795267
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02550826
125* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01161076
126* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00634107
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.99339637
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99289640
129MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99206583
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99147964
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98891755
132NFI_21473784_ChIP-Seq_ESCs_Mouse0.98782920
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98188256
134NCOR1_26117541_ChIP-Seq_K562_Human0.98150435
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98101837
136CBP_20019798_ChIP-Seq_JUKART_Human0.97317693
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97317693
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96496454
139RUNX_20019798_ChIP-Seq_JUKART_Human0.96248321
140MYB_26560356_Chip-Seq_TH1_Human0.96144475
141EP300_21415370_ChIP-Seq_HL-1_Mouse0.95681462
142UTX_26944678_Chip-Seq_JUKART_Human0.94446424
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93813005
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93208903
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92291965
146* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91898437
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91161470
148* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90250898
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89909267
150VDR_21846776_ChIP-Seq_THP-1_Human0.89829553
151KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89493917
152AR_25329375_ChIP-Seq_VCAP_Human0.89063017
153* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89041198
154* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88908646
155TCF4_23295773_ChIP-Seq_U87_Human0.88834307
156LXR_22158963_ChIP-Seq_LIVER_Mouse0.88517444
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88455395
158DCP1A_22483619_ChIP-Seq_HELA_Human0.87459134
159TCF7_22412390_ChIP-Seq_EML_Mouse0.86119999
160* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85918731
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85720048
162* STAT3_23295773_ChIP-Seq_U87_Human0.85554259
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85356497
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84689521
165PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82892290
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82495327
167FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82014343
168KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81869271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.64410267
2MP0005187_abnormal_penis_morphology7.62040441
3MP0005670_abnormal_white_adipose7.58246182
4MP0003315_abnormal_perineum_morphology4.96619006
5MP0002009_preneoplasia4.82924307
6MP0003705_abnormal_hypodermis_morpholog4.73739037
7MP0005275_abnormal_skin_tensile4.35845142
8MP0003279_aneurysm3.65928237
9MP0005503_abnormal_tendon_morphology3.33740477
10MP0010352_gastrointestinal_tract_polyps3.04483008
11MP0005623_abnormal_meninges_morphology3.02304400
12MP0002006_tumorigenesis2.96678153
13MP0002877_abnormal_melanocyte_morpholog2.93987188
14MP0003300_gastrointestinal_ulcer2.87278972
15MP0009384_cardiac_valve_regurgitation2.86800998
16MP0001958_emphysema2.80600658
17MP0005023_abnormal_wound_healing2.40112376
18MP0003091_abnormal_cell_migration2.31848489
19MP0002166_altered_tumor_susceptibility2.21193755
20MP0002148_abnormal_hypersensitivity_rea2.12258795
21MP0001879_abnormal_lymphatic_vessel2.09758732
22MP0004215_abnormal_myocardial_fiber2.08717726
23MP0003303_peritoneal_inflammation2.03882680
24MP0003566_abnormal_cell_adhesion2.00816262
25MP0003045_fibrosis1.98771101
26MP0003136_yellow_coat_color1.98698820
27MP0008877_abnormal_DNA_methylation1.92844960
28MP0005508_abnormal_skeleton_morphology1.87730809
29MP0006054_spinal_hemorrhage1.83174173
30MP0002060_abnormal_skin_morphology1.83116394
31MP0004264_abnormal_extraembryonic_tissu1.78836488
32MP0001243_abnormal_dermal_layer1.77745711
33MP0005167_abnormal_blood-brain_barrier1.77455160
34MP0002933_joint_inflammation1.72719816
35MP0002796_impaired_skin_barrier1.70500194
36MP0008004_abnormal_stomach_pH1.70017653
37MP0001348_abnormal_lacrimal_gland1.69047654
38MP0000733_abnormal_muscle_development1.67075104
39MP0001542_abnormal_bone_strength1.67028968
40MP0005076_abnormal_cell_differentiation1.61227978
41MP0004084_abnormal_cardiac_muscle1.61120504
42MP0010030_abnormal_orbit_morphology1.58449292
43MP0004808_abnormal_hematopoietic_stem1.57399219
44MP0002896_abnormal_bone_mineralization1.56722897
45MP0002098_abnormal_vibrissa_morphology1.55438838
46MP0005397_hematopoietic_system_phenotyp1.54869198
47MP0001545_abnormal_hematopoietic_system1.54869198
48MP0001299_abnormal_eye_distance/1.43614741
49MP0005666_abnormal_adipose_tissue1.41750967
50MP0003787_abnormal_imprinting1.41511186
51MP0009278_abnormal_bone_marrow1.40337930
52MP0002295_abnormal_pulmonary_circulatio1.31601856
53MP0005390_skeleton_phenotype1.30008297
54MP0003828_pulmonary_edema1.26937143
55MP0005595_abnormal_vascular_smooth1.25905409
56MP0002168_other_aberrant_phenotype1.22572113
57MP0003868_abnormal_feces_composition1.22465957
58MP0003385_abnormal_body_wall1.21720748
59MP0009250_abnormal_appendicular_skeleto1.21634699
60MP0001533_abnormal_skeleton_physiology1.20525673
61MP0005257_abnormal_intraocular_pressure1.17347477
62MP0001986_abnormal_taste_sensitivity1.17290578
63MP0003806_abnormal_nucleotide_metabolis1.15796762
64MP0000465_gastrointestinal_hemorrhage1.14513260
65MP0002876_abnormal_thyroid_physiology1.14435171
66MP0006138_congestive_heart_failure1.14215082
67MP0008007_abnormal_cellular_replicative1.14008970
68MP0004272_abnormal_basement_membrane1.11893713
69MP0009697_abnormal_copulation1.11463253
70MP0004947_skin_inflammation1.10048043
71MP0002998_abnormal_bone_remodeling1.05813589
72MP0000428_abnormal_craniofacial_morphol1.04823234
73MP0009053_abnormal_anal_canal1.01353453
74MP0000767_abnormal_smooth_muscle1.01056619
75MP0006072_abnormal_retinal_apoptosis1.00532762
76MP0003795_abnormal_bone_structure1.00379697
77MP0003252_abnormal_bile_duct0.99801471
78MP0002113_abnormal_skeleton_development0.99490613
79MP0003436_decreased_susceptibility_to0.97900789
80MP0010307_abnormal_tumor_latency0.95785576
81MP0002115_abnormal_skeleton_extremities0.95753995
82MP0005171_absent_coat_pigmentation0.94402829
83MP0009379_abnormal_foot_pigmentation0.94121122
84MP0002396_abnormal_hematopoietic_system0.93344689
85MP0001873_stomach_inflammation0.91469089
86MP0003724_increased_susceptibility_to0.91435269
87MP0005375_adipose_tissue_phenotype0.90066455
88MP0000681_abnormal_thyroid_gland0.88780706
89MP0000858_altered_metastatic_potential0.88679623
90MP0003011_delayed_dark_adaptation0.88440750
91MP0003942_abnormal_urinary_system0.88050578
92MP0000490_abnormal_crypts_of0.87725538
93MP0009764_decreased_sensitivity_to0.87683179
94MP0003950_abnormal_plasma_membrane0.87357804
95MP0001853_heart_inflammation0.86268677
96MP0005165_increased_susceptibility_to0.83257950
97MP0010368_abnormal_lymphatic_system0.81748697
98MP0002128_abnormal_blood_circulation0.81406853
99MP0000750_abnormal_muscle_regeneration0.78386425
100MP0004484_altered_response_of0.78349949
101MP0004510_myositis0.77526351
102MP0003937_abnormal_limbs/digits/tail_de0.76712760
103MP0000627_abnormal_mammary_gland0.76476144
104MP0003448_altered_tumor_morphology0.75179753
105MP0000467_abnormal_esophagus_morphology0.74333093
106MP0000343_altered_response_to0.74181098
107MP0000163_abnormal_cartilage_morphology0.73196724
108MP0005197_abnormal_uvea_morphology0.72146013
109MP0008770_decreased_survivor_rate0.71676012
110MP0002089_abnormal_postnatal_growth/wei0.70866329
111MP0009333_abnormal_splenocyte_physiolog0.70617308
112MP0005174_abnormal_tail_pigmentation0.70377175
113MP0005395_other_phenotype0.69597441
114MP0004036_abnormal_muscle_relaxation0.69117451
115MP0000249_abnormal_blood_vessel0.68227013
116MP0000647_abnormal_sebaceous_gland0.67934723
117MP0000013_abnormal_adipose_tissue0.67629585
118MP0010771_integument_phenotype0.67114138
119MP0008775_abnormal_heart_ventricle0.66431560
120MP0003755_abnormal_palate_morphology0.66298510
121MP0002177_abnormal_outer_ear0.66286492
122MP0000534_abnormal_ureter_morphology0.66019050
123MP0001915_intracranial_hemorrhage0.65695970
124MP0002932_abnormal_joint_morphology0.65656133
125MP0002405_respiratory_system_inflammati0.64695851
126MP0005000_abnormal_immune_tolerance0.64653515
127MP0001790_abnormal_immune_system0.63929908
128MP0005387_immune_system_phenotype0.63929908
129MP0003283_abnormal_digestive_organ0.63245372
130MP0003453_abnormal_keratinocyte_physiol0.63234483
131MP0000230_abnormal_systemic_arterial0.62854556
132MP0001177_atelectasis0.62553241
133MP0000432_abnormal_head_morphology0.61596195
134MP0003191_abnormal_cellular_cholesterol0.61014985
135MP0001614_abnormal_blood_vessel0.60448169
136MP0005253_abnormal_eye_physiology0.58491638
137MP0002133_abnormal_respiratory_system0.58306013
138MP0005388_respiratory_system_phenotype0.58306013
139MP0002925_abnormal_cardiovascular_devel0.57204915
140MP0004197_abnormal_fetal_growth/weight/0.56943833
141MP0003115_abnormal_respiratory_system0.56616095
142MP0005621_abnormal_cell_physiology0.56336164
143MP0000569_abnormal_digit_pigmentation0.56239460
144MP0002109_abnormal_limb_morphology0.55524803
145MP0005164_abnormal_response_to0.54842624
146MP0004134_abnormal_chest_morphology0.54653937
147MP0005084_abnormal_gallbladder_morpholo0.54639501
148MP0008057_abnormal_DNA_replication0.52983591
149MP0001784_abnormal_fluid_regulation0.52412651
150MP0001119_abnormal_female_reproductive0.52212566
151MP0001175_abnormal_lung_morphology0.48752356
152MP0003936_abnormal_reproductive_system0.47972456
153MP0002138_abnormal_hepatobiliary_system0.47593705
154MP0004782_abnormal_surfactant_physiolog0.45604107
155MP0009780_abnormal_chondrocyte_physiolo0.44581013
156MP0005365_abnormal_bile_salt0.43321846
157MP0005501_abnormal_skin_physiology0.42922613
158MP0002127_abnormal_cardiovascular_syste0.40882714
159MP0001270_distended_abdomen0.40229689
160MP0001501_abnormal_sleep_pattern0.38585408
161MP0005464_abnormal_platelet_physiology0.38154834
162MP0000383_abnormal_hair_follicle0.35709475
163MP0005330_cardiomyopathy0.34072756

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)9.48710202
2Premature rupture of membranes (HP:0001788)8.11791341
3Protrusio acetabuli (HP:0003179)7.17051609
4Peritonitis (HP:0002586)5.31122491
5Cervical subluxation (HP:0003308)4.86861075
6Ectropion (HP:0000656)4.50104398
7Aortic dissection (HP:0002647)4.47552589
8Shallow orbits (HP:0000586)4.42291727
9Dilatation of the ascending aorta (HP:0005111)4.35526757
10Papilledema (HP:0001085)4.23823371
11Abnormality of chromosome segregation (HP:0002916)4.21156026
12Tubulointerstitial nephritis (HP:0001970)4.20202493
13Hyperkalemia (HP:0002153)4.18449456
14Soft skin (HP:0000977)4.10471374
15Spinal cord lesions (HP:0100561)4.09122512
16Syringomyelia (HP:0003396)4.09122512
17Thickened helices (HP:0000391)4.08003546
18Ankle contracture (HP:0006466)3.91859141
19Hemorrhage of the eye (HP:0011885)3.91400586
20Atrophic scars (HP:0001075)3.77256283
21Short nail (HP:0001799)3.77025161
22Aortic aneurysm (HP:0004942)3.76533861
23Thick nail (HP:0001805)3.75887048
24Global brain atrophy (HP:0002283)3.70120585
25Fragile skin (HP:0001030)3.53489555
26Vertebral compression fractures (HP:0002953)3.53062216
27Genu recurvatum (HP:0002816)3.44745955
28Large for gestational age (HP:0001520)3.44461895
29Generalized myoclonic seizures (HP:0002123)3.38188691
30Bladder diverticulum (HP:0000015)3.35335248
31Cerebral aneurysm (HP:0004944)3.34550436
32Increased density of long bones (HP:0006392)3.32143010
33Increased CSF protein (HP:0002922)3.27841888
34Hyporeflexia of lower limbs (HP:0002600)3.27137437
35Erythema (HP:0010783)3.26042831
36Blepharitis (HP:0000498)3.25850430
37Increased mean platelet volume (HP:0011877)3.19675907
38Wrist flexion contracture (HP:0001239)3.16912274
39Wormian bones (HP:0002645)3.16470964
40Abnormality of dentin (HP:0010299)3.15363094
41Ankyloglossia (HP:0010296)3.06287590
42Mitral valve prolapse (HP:0001634)3.00961682
43Osteolytic defects of the hand bones (HP:0009699)2.98766976
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.98766976
45Blue sclerae (HP:0000592)2.96650606
46Increased connective tissue (HP:0009025)2.96492971
47Abnormal platelet volume (HP:0011876)2.96176374
48Abnormality of dental color (HP:0011073)2.94288973
49Biconcave vertebral bodies (HP:0004586)2.93414525
50Bowel diverticulosis (HP:0005222)2.92235239
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91898654
52Abnormal protein N-linked glycosylation (HP:0012347)2.91898654
53Abnormal protein glycosylation (HP:0012346)2.91898654
54Abnormal glycosylation (HP:0012345)2.91898654
55Mesomelia (HP:0003027)2.91778531
56Spastic paraparesis (HP:0002313)2.87747228
57Autoamputation (HP:0001218)2.86877935
58Radial bowing (HP:0002986)2.84054574
59Sensory axonal neuropathy (HP:0003390)2.76657062
60Bilateral sensorineural hearing impairment (HP:0008619)2.76191788
61Neonatal short-limb short stature (HP:0008921)2.74911837
62Coronal craniosynostosis (HP:0004440)2.72068250
63Spinal rigidity (HP:0003306)2.69353168
64Broad face (HP:0000283)2.64985085
65Broad metatarsal (HP:0001783)2.64947972
66Abnormality of the intrinsic pathway (HP:0010989)2.61820286
67Menorrhagia (HP:0000132)2.59923612
68Autoimmune thrombocytopenia (HP:0001973)2.58715241
69Redundant skin (HP:0001582)2.57167687
70Infantile muscular hypotonia (HP:0008947)2.56456304
71Abnormality of the peritoneum (HP:0002585)2.55660220
72White forelock (HP:0002211)2.55434439
73Cone-rod dystrophy (HP:0000548)2.54242820
74Spinal cord compression (HP:0002176)2.53470037
75Vascular tortuosity (HP:0004948)2.52181206
76Oligomenorrhea (HP:0000876)2.51433583
77Abnormal delivery (HP:0001787)2.49431323
78Hypoplastic ischia (HP:0003175)2.47207669
79Hematochezia (HP:0002573)2.46529645
80Sparse eyelashes (HP:0000653)2.45293421
81Aplastic anemia (HP:0001915)2.44477005
82Abnormality of the acetabulum (HP:0003170)2.40522471
83Deviation of the hallux (HP:0010051)2.37696161
84Keratitis (HP:0000491)2.37445520
85Abnormality of the calcaneus (HP:0008364)2.36480386
86Abnormality of the ischium (HP:0003174)2.34011734
87Tetraparesis (HP:0002273)2.32270949
88Autoimmune hemolytic anemia (HP:0001890)2.32216461
89Hallux valgus (HP:0001822)2.29778748
90Bowing of the arm (HP:0006488)2.29506953
91Bowed forearm bones (HP:0003956)2.29506953
92Patchy hypopigmentation of hair (HP:0011365)2.28343495
93Facial diplegia (HP:0001349)2.25863901
94Follicular hyperkeratosis (HP:0007502)2.24168806
95Distal lower limb amyotrophy (HP:0008944)2.23056913
96Dysmetria (HP:0001310)2.22996438
97Nail dystrophy (HP:0008404)2.22849502
98Spontaneous hematomas (HP:0007420)2.22370150
99Premature skin wrinkling (HP:0100678)2.21618035
100Ulnar bowing (HP:0003031)2.21115276
101Congenital, generalized hypertrichosis (HP:0004540)2.20823337
102Tibial bowing (HP:0002982)2.20204242
103Cerebral hemorrhage (HP:0001342)2.18272991
104Elbow flexion contracture (HP:0002987)2.17918673
105Mitral regurgitation (HP:0001653)2.14305629
106Slender build (HP:0001533)2.14061152
107Hypertensive crisis (HP:0100735)2.13858568
108Arterial tortuosity (HP:0005116)2.11848129
109Hyperextensible skin (HP:0000974)2.09885702
110Overgrowth (HP:0001548)2.07285229
111Abnormality of incisor morphology (HP:0011063)2.06943434
112Thin bony cortex (HP:0002753)2.06635646
113Abnormality of chloride homeostasis (HP:0011422)2.05743890
114Enlarged kidneys (HP:0000105)2.02154648
115Absent frontal sinuses (HP:0002688)2.00635833
116Abnormal auditory evoked potentials (HP:0006958)2.00427373
117Abnormality of the distal phalanges of the toes (HP:0010182)1.99163534
118Fibular aplasia (HP:0002990)1.96895439
119Difficulty climbing stairs (HP:0003551)1.96003144
120Atelectasis (HP:0100750)1.95954699
121Type 1 muscle fiber predominance (HP:0003803)1.95573109
122Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95186975
123Skull defect (HP:0001362)1.94490480
124Decreased testicular size (HP:0008734)1.93789473
125Corneal dystrophy (HP:0001131)1.93329932
126Nonimmune hydrops fetalis (HP:0001790)1.92420031
127Renal cortical cysts (HP:0000803)1.92000590
128Aneurysm (HP:0002617)1.90817767
129Polycythemia (HP:0001901)1.90382726
130Broad long bones (HP:0005622)1.90129583
131Decreased skull ossification (HP:0004331)1.89855405
132Spondylolisthesis (HP:0003302)1.88886276
133Beaking of vertebral bodies (HP:0004568)1.88151137
134Alveolar cell carcinoma (HP:0006519)1.87606095
135Ectopia lentis (HP:0001083)1.86947844
136Abnormality of the pericardium (HP:0001697)1.86472522
137Ovoid vertebral bodies (HP:0003300)1.84939442
138Synophrys (HP:0000664)1.84639717
139Focal seizures (HP:0007359)1.83175934
140Distal upper limb amyotrophy (HP:0007149)1.82702571
141Upper limb amyotrophy (HP:0009129)1.82702571
142Scapular winging (HP:0003691)1.82471975
143Rectal prolapse (HP:0002035)1.82363220
144Abnormality of skull ossification (HP:0002703)1.81251673
145Aplasia involving bones of the upper limbs (HP:0009823)1.81191583
146Aplasia of the phalanges of the hand (HP:0009802)1.81191583
147Aplasia involving bones of the extremities (HP:0009825)1.81191583
148Abnormality of oral frenula (HP:0000190)1.81016057
149Hypogonadotrophic hypogonadism (HP:0000044)1.80938169
150Stenosis of the external auditory canal (HP:0000402)1.80261842
151Delayed cranial suture closure (HP:0000270)1.79102619
152Camptodactyly of toe (HP:0001836)1.78142865
153Achilles tendon contracture (HP:0001771)1.76938347
154Mildly elevated creatine phosphokinase (HP:0008180)1.76687099
155Coxa vara (HP:0002812)1.76668518
156Abnormality of the odontoid process (HP:0003310)1.76342079
157Joint laxity (HP:0001388)1.75595519
158High pitched voice (HP:0001620)1.74988948
159Muscle fibrillation (HP:0010546)1.74954746
160Glucose intolerance (HP:0000833)1.74951791
161Tubular atrophy (HP:0000092)1.74694750
162Venous abnormality (HP:0002624)1.73910794
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73857217
164Adactyly (HP:0009776)1.73029128
165Short middle phalanx of the 5th finger (HP:0004220)1.72049679
166Neoplasm of the tracheobronchial system (HP:0100552)1.72049619
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.71647093
168Natal tooth (HP:0000695)1.71487584
169Lower limb amyotrophy (HP:0007210)1.70678912
170Anhidrosis (HP:0000970)1.69991503
171Gastrointestinal infarctions (HP:0005244)1.69457850
172Persistence of primary teeth (HP:0006335)1.68987652
173Tongue fasciculations (HP:0001308)1.68472546
174Metaphyseal dysplasia (HP:0100255)1.68395858
175Buphthalmos (HP:0000557)1.66946952
176Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66924842
177Decreased subcutaneous fat (HP:0001002)1.66687620
178Impaired platelet aggregation (HP:0003540)1.66682740
179Abnormal platelet function (HP:0011869)1.66682740
180Atrial fibrillation (HP:0005110)1.66510841
181Thin skin (HP:0000963)1.66463865
182Joint stiffness (HP:0001387)1.66352593
183Aortic regurgitation (HP:0001659)1.65207782
184Epiphyseal dysplasia (HP:0002656)1.64578799
185Delayed closure of the anterior fontanelle (HP:0001476)1.63886428
186Esophageal varix (HP:0002040)1.60704560
187Reduced subcutaneous adipose tissue (HP:0003758)1.60592677
188Asymmetric septal hypertrophy (HP:0001670)1.60205076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.06390644
2TTN4.64489996
3DDR24.25432448
4BMPR23.85217014
5EEF2K3.64500875
6PDGFRA3.07412175
7TXK2.99384157
8TRIB32.90538867
9AKT32.83418271
10PRPF4B2.59853215
11NME22.46305051
12TRPM72.33392244
13PKN22.24780303
14SCYL22.23267527
15BMX2.13904921
16MAP3K122.12573082
17LATS12.05950966
18PAK22.05603201
19TAOK32.05583630
20RPS6KA42.03169028
21INSRR1.87717587
22LRRK21.76335393
23CDK91.74408164
24LATS21.74008981
25NEK91.72896247
26CDK31.71504225
27LIMK11.61650767
28NEK61.60552279
29TESK21.60343372
30STK31.58402330
31MYLK1.52321367
32TEC1.51064599
33TESK11.50056995
34EPHA21.48801506
35PTK21.41450906
36PIM21.30017665
37STK101.26650689
38MOS1.24169452
39MAP4K21.20207929
40PLK21.18850349
41JAK11.17566392
42PAK31.16394012
43PDGFRB1.14447662
44JAK31.13584821
45STK38L1.12896813
46TGFBR11.10790429
47CDC71.08836725
48FER1.08398094
49KIT1.07836508
50CDK61.06525105
51FGFR11.06209133
52PAK41.05797968
53FRK1.02723217
54SIK10.99435357
55NEK20.99363141
56EIF2AK10.96232605
57MAP3K30.95249595
58CDC42BPA0.94243555
59PRKD20.92735878
60TAOK20.92448940
61MAP3K80.92269915
62MKNK10.86864999
63ERBB30.86193597
64PASK0.85351054
65MAPKAPK50.84097069
66JAK20.83333434
67IRAK10.81574508
68PTK60.80613529
69DMPK0.79511157
70EPHB20.79496672
71FES0.78783908
72ACVR1B0.78432438
73PLK30.78220604
74TGFBR20.77648087
75ERN10.76941012
76BRSK20.75981968
77PTK2B0.74895715
78ADRBK20.73543740
79CAMKK20.73210836
80PRKCE0.70565824
81ALK0.69503381
82MTOR0.68337619
83BMPR1B0.68328749
84PIK3CG0.67878345
85NUAK10.64930245
86KDR0.62998788
87CSNK1A10.62105741
88AURKB0.61778231
89TLK10.61296172
90PIK3CA0.61279768
91TBK10.60953188
92MAP2K70.60852711
93MAPK110.60682724
94TTK0.59693108
95ILK0.59098543
96PRKD30.58965767
97HCK0.58484423
98PNCK0.58405069
99MAP2K30.57757821
100ZAK0.56940454
101MAP3K10.56176470
102INSR0.55881516
103STK380.55338227
104MKNK20.55027467
105PAK10.53974902
106MST1R0.53230098
107ROCK10.51262949
108MET0.50862859
109CAMKK10.50860899
110CSK0.50613004
111ERBB20.48718281
112ABL20.47726644
113IKBKB0.47255823
114MAP3K140.47037624
115ITK0.46856902
116CDK120.44176055
117DAPK20.44054637
118ADRBK10.43676107
119PRKCH0.43232204
120CDK150.41480823
121PLK10.41048736
122ROCK20.40306070
123ZAP700.39986393
124WEE10.39816498
125MAP2K10.38896467
126DYRK20.38789806
127FGFR30.38616808
128MAPKAPK20.38110037
129CDK140.38051746
130CDK180.37501615
131IGF1R0.37491001
132EPHA30.37436867
133MATK0.36931540
134RIPK10.36916665
135CDK40.36334875
136BUB10.35790241
137EPHB10.35605573
138CLK10.35319433
139EIF2AK20.34954119
140CAMK1G0.34529021
141CDK11A0.32527037
142SRC0.31612095
143ABL10.31441165
144TYK20.28793597
145PKN10.27643092
146PRKD10.22948342
147SGK20.22687829
148EIF2AK30.22403018
149PDPK10.21285026
150MAP2K20.20133128
151CAMK40.19887638
152MAP3K40.19700706
153EPHA40.19202458
154BTK0.18766493
155PHKG20.17351705
156PHKG10.17351705
157GRK70.17193529
158IRAK20.16202630
159PRKCA0.15934169
160ERBB40.15749071
161NTRK10.15739835
162PBK0.15549623
163SGK30.15460873

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.48704130
2Fatty acid biosynthesis_Homo sapiens_hsa000613.87922450
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62494159
4Renin-angiotensin system_Homo sapiens_hsa046142.52676990
5ECM-receptor interaction_Homo sapiens_hsa045122.51042419
6Allograft rejection_Homo sapiens_hsa053302.39366186
7Autoimmune thyroid disease_Homo sapiens_hsa053202.26713481
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22575293
9Malaria_Homo sapiens_hsa051442.13780443
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.12327359
11Focal adhesion_Homo sapiens_hsa045102.07004438
12Shigellosis_Homo sapiens_hsa051311.96560482
13Proteoglycans in cancer_Homo sapiens_hsa052051.93423447
14Complement and coagulation cascades_Homo sapiens_hsa046101.89495554
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75261359
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74986556
17p53 signaling pathway_Homo sapiens_hsa041151.73120364
18Dorso-ventral axis formation_Homo sapiens_hsa043201.67738426
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66026164
20MicroRNAs in cancer_Homo sapiens_hsa052061.63630206
21Chronic myeloid leukemia_Homo sapiens_hsa052201.63512311
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.59562153
23Calcium signaling pathway_Homo sapiens_hsa040201.57196874
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54378554
25Small cell lung cancer_Homo sapiens_hsa052221.52949020
26Bladder cancer_Homo sapiens_hsa052191.52323743
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51003287
28Hematopoietic cell lineage_Homo sapiens_hsa046401.48380536
29TNF signaling pathway_Homo sapiens_hsa046681.48293637
30Leishmaniasis_Homo sapiens_hsa051401.46334681
31Adherens junction_Homo sapiens_hsa045201.46317590
32Basal transcription factors_Homo sapiens_hsa030221.45615040
33One carbon pool by folate_Homo sapiens_hsa006701.42730385
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42327387
35Amoebiasis_Homo sapiens_hsa051461.38863150
36Viral carcinogenesis_Homo sapiens_hsa052031.37521424
37Platelet activation_Homo sapiens_hsa046111.37237418
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34493843
39Viral myocarditis_Homo sapiens_hsa054161.30763104
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29884515
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25310020
42ABC transporters_Homo sapiens_hsa020101.23881683
43TGF-beta signaling pathway_Homo sapiens_hsa043501.23591976
44Arginine and proline metabolism_Homo sapiens_hsa003301.22610451
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17132178
46Sulfur metabolism_Homo sapiens_hsa009201.16714136
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.16642871
48Melanoma_Homo sapiens_hsa052181.16129495
49Salmonella infection_Homo sapiens_hsa051321.14197317
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13771579
51Toxoplasmosis_Homo sapiens_hsa051451.12308131
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11329616
53Apoptosis_Homo sapiens_hsa042101.11255564
54Cell cycle_Homo sapiens_hsa041101.11181085
55PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09264066
56GnRH signaling pathway_Homo sapiens_hsa049121.08995972
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.07640581
58Sphingolipid metabolism_Homo sapiens_hsa006001.07087122
59Phagosome_Homo sapiens_hsa041451.04287465
60Pancreatic cancer_Homo sapiens_hsa052121.00591498
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99478732
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99380140
63Lysosome_Homo sapiens_hsa041420.98670297
64Hepatitis B_Homo sapiens_hsa051610.96923048
65Dilated cardiomyopathy_Homo sapiens_hsa054140.96644342
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.94903574
67Protein digestion and absorption_Homo sapiens_hsa049740.93161267
68Pertussis_Homo sapiens_hsa051330.91317077
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90127294
70Glioma_Homo sapiens_hsa052140.89408311
71HTLV-I infection_Homo sapiens_hsa051660.88636510
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86741510
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84940348
74Measles_Homo sapiens_hsa051620.83801412
75Rap1 signaling pathway_Homo sapiens_hsa040150.83251937
76Osteoclast differentiation_Homo sapiens_hsa043800.82071692
77Systemic lupus erythematosus_Homo sapiens_hsa053220.81141408
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.80456973
79PPAR signaling pathway_Homo sapiens_hsa033200.79562632
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78668602
81Selenocompound metabolism_Homo sapiens_hsa004500.77885133
82Hippo signaling pathway_Homo sapiens_hsa043900.77435589
83T cell receptor signaling pathway_Homo sapiens_hsa046600.76162266
84Legionellosis_Homo sapiens_hsa051340.75466663
85Thyroid hormone synthesis_Homo sapiens_hsa049180.73946697
86Basal cell carcinoma_Homo sapiens_hsa052170.72841229
87Insulin resistance_Homo sapiens_hsa049310.72604248
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72204924
89N-Glycan biosynthesis_Homo sapiens_hsa005100.71971361
90Wnt signaling pathway_Homo sapiens_hsa043100.70865561
91Prostate cancer_Homo sapiens_hsa052150.70665358
92Arachidonic acid metabolism_Homo sapiens_hsa005900.69690276
93Taste transduction_Homo sapiens_hsa047420.69624655
94RNA transport_Homo sapiens_hsa030130.68999858
95Rheumatoid arthritis_Homo sapiens_hsa053230.68078812
96HIF-1 signaling pathway_Homo sapiens_hsa040660.66598203
97Collecting duct acid secretion_Homo sapiens_hsa049660.66269418
98Ether lipid metabolism_Homo sapiens_hsa005650.66084042
99DNA replication_Homo sapiens_hsa030300.66038949
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.64621556
101Linoleic acid metabolism_Homo sapiens_hsa005910.62519288
102Pathways in cancer_Homo sapiens_hsa052000.61751140
103African trypanosomiasis_Homo sapiens_hsa051430.60245949
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59049326
105Tuberculosis_Homo sapiens_hsa051520.58411861
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.57997594
107Axon guidance_Homo sapiens_hsa043600.57936382
108Fat digestion and absorption_Homo sapiens_hsa049750.57730876
109VEGF signaling pathway_Homo sapiens_hsa043700.57472973
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.56890817
111Hedgehog signaling pathway_Homo sapiens_hsa043400.55826915
112Renin secretion_Homo sapiens_hsa049240.54235941
113Epstein-Barr virus infection_Homo sapiens_hsa051690.53132614
114Melanogenesis_Homo sapiens_hsa049160.51854128
115Proteasome_Homo sapiens_hsa030500.51848165
116Endocytosis_Homo sapiens_hsa041440.50783593
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50556451
118Gap junction_Homo sapiens_hsa045400.50225141
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50160339
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.49413572
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49243919
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48848355
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.48624304
124Protein export_Homo sapiens_hsa030600.48293150
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.47925435
126Colorectal cancer_Homo sapiens_hsa052100.47572603
127FoxO signaling pathway_Homo sapiens_hsa040680.46490481
128Ovarian steroidogenesis_Homo sapiens_hsa049130.46465369
129Olfactory transduction_Homo sapiens_hsa047400.46109416
130Chemokine signaling pathway_Homo sapiens_hsa040620.45872172
131ErbB signaling pathway_Homo sapiens_hsa040120.45300621
132Antigen processing and presentation_Homo sapiens_hsa046120.44684258
133Mineral absorption_Homo sapiens_hsa049780.44203675
134Vitamin digestion and absorption_Homo sapiens_hsa049770.44109559
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43187330
136Renal cell carcinoma_Homo sapiens_hsa052110.42955141
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.42909883
138Acute myeloid leukemia_Homo sapiens_hsa052210.40337915
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39535614
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39499094
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38097626
142Non-small cell lung cancer_Homo sapiens_hsa052230.37864177
143Ras signaling pathway_Homo sapiens_hsa040140.37732626
144Serotonergic synapse_Homo sapiens_hsa047260.37693074
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37402701
146Prolactin signaling pathway_Homo sapiens_hsa049170.37129519
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37120615
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36581287
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36547769
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35576341
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35513859
152Tight junction_Homo sapiens_hsa045300.34375273

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