IL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)9.69908696
2pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)8.93874040
3UMP metabolic process (GO:0046049)8.93874040
4pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)8.93874040
5UMP biosynthetic process (GO:0006222)8.93874040
6regulation of interleukin-12 biosynthetic process (GO:0045075)8.59375093
7regulation of T cell chemotaxis (GO:0010819)8.33688913
8positive regulation of T cell chemotaxis (GO:0010820)8.33688913
9* regulation of immunoglobulin secretion (GO:0051023)8.20570034
10* regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.91716580
11regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)7.73752331
12pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)7.48355043
13regulation of podosome assembly (GO:0071801)7.21793086
14regulation of memory T cell differentiation (GO:0043380)7.13598900
15regulation of vitamin D biosynthetic process (GO:0060556)6.92294007
16pyrimidine nucleoside monophosphate metabolic process (GO:0009129)6.89996102
17positive regulation of humoral immune response (GO:0002922)6.87388700
18regulation of vitamin metabolic process (GO:0030656)6.17413831
19positive regulation of macrophage derived foam cell differentiation (GO:0010744)6.15305552
20regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.13788658
21positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.13788658
22pyrimidine ribonucleoside biosynthetic process (GO:0046132)6.12055951
23negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)6.10142011
24tyrosine phosphorylation of STAT protein (GO:0007260)6.05988514
25* positive regulation of B cell mediated immunity (GO:0002714)6.00194326
26* positive regulation of immunoglobulin mediated immune response (GO:0002891)6.00194326
27regulation of lymphocyte chemotaxis (GO:1901623)5.86861634
28pyrimidine ribonucleotide biosynthetic process (GO:0009220)5.85136882
29myeloid dendritic cell differentiation (GO:0043011)5.83129157
30polarized epithelial cell differentiation (GO:0030859)5.79578625
31response to gravity (GO:0009629)5.75400128
32cellular response to nicotine (GO:0071316)5.74699950
33regulation of gamma-delta T cell differentiation (GO:0045586)5.65592631
34cellular protein complex localization (GO:0034629)5.60856600
35positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.59990809
36regulation of chronic inflammatory response (GO:0002676)5.29594411
37pyrimidine ribonucleotide metabolic process (GO:0009218)5.25083407
38signal peptide processing (GO:0006465)5.24965361
39positive regulation of T cell cytokine production (GO:0002726)5.22030058
40positive regulation of gamma-delta T cell activation (GO:0046645)5.18928260
41* regulation of isotype switching to IgG isotypes (GO:0048302)5.13314909
42regulation of gamma-delta T cell activation (GO:0046643)5.07245567
43myeloid dendritic cell activation (GO:0001773)5.03538894
44* regulation of immunoglobulin production (GO:0002637)4.98039105
45positive regulation of endothelial cell apoptotic process (GO:2000353)4.85736283
46regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.75035281
47positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.68351967
48GTP biosynthetic process (GO:0006183)4.66770678
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.66057169
50ribosome biogenesis (GO:0042254)4.63783429
51pyrimidine nucleotide biosynthetic process (GO:0006221)4.60943970
52* regulation of immunoglobulin mediated immune response (GO:0002889)4.57235262
53activated T cell proliferation (GO:0050798)4.57228377
54negative T cell selection (GO:0043383)4.50836605
55regulation of alpha-beta T cell proliferation (GO:0046640)4.47455044
56interferon-gamma production (GO:0032609)4.46560094
57negative regulation of T cell mediated immunity (GO:0002710)4.44506999
58behavioral response to nicotine (GO:0035095)4.44155449
59* positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)4.43599812
60regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.41501839
61* regulation of B cell mediated immunity (GO:0002712)4.40827196
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.39752607
63* positive regulation of isotype switching (GO:0045830)4.39114198
64regulation of fever generation (GO:0031620)4.36922547
65positive regulation of heat generation (GO:0031652)4.29174175
66pyrimidine nucleoside biosynthetic process (GO:0046134)4.28889962
67T cell proliferation (GO:0042098)4.21937037
68negative thymic T cell selection (GO:0045060)4.20294575
69positive regulation of defense response to virus by host (GO:0002230)4.19554480
70positive thymic T cell selection (GO:0045059)4.18873378
71* positive regulation of immunoglobulin production (GO:0002639)4.16907241
72UTP biosynthetic process (GO:0006228)4.12634515
73CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.09394844
74pyrimidine ribonucleoside metabolic process (GO:0046131)4.04416902
75positive regulation of alpha-beta T cell proliferation (GO:0046641)4.03193268
76T cell homeostasis (GO:0043029)3.98175362
77positive regulation of astrocyte differentiation (GO:0048711)3.98108665
78positive regulation of T cell migration (GO:2000406)3.96593648
79regulation of lymphocyte migration (GO:2000401)3.95299196
80positive T cell selection (GO:0043368)3.94727026
81response to interleukin-15 (GO:0070672)3.92674891
82CTP biosynthetic process (GO:0006241)3.92485646
83CTP metabolic process (GO:0046036)3.92485646
84embryonic hemopoiesis (GO:0035162)3.91825267
85positive regulation of immune response to tumor cell (GO:0002839)3.89637564
86regulation of immune response to tumor cell (GO:0002837)3.89637564
87regulation of response to tumor cell (GO:0002834)3.89637564
88positive regulation of response to tumor cell (GO:0002836)3.89637564
89* positive regulation of interleukin-17 production (GO:0032740)3.88072261
90* regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.86373947
91positive regulation of lymphocyte migration (GO:2000403)3.85294354
92protein complex localization (GO:0031503)3.84409102
93positive regulation of cell fate commitment (GO:0010455)3.76845157
94* positive regulation of lymphocyte mediated immunity (GO:0002708)3.71452374
95amine catabolic process (GO:0009310)3.71178179
96cellular biogenic amine catabolic process (GO:0042402)3.71178179
97* regulation of JAK-STAT cascade (GO:0046425)3.69546120
98folic acid transport (GO:0015884)3.68107064
99* positive regulation of JAK-STAT cascade (GO:0046427)3.67579826
100UTP metabolic process (GO:0046051)3.65023817
101cellular response to interleukin-15 (GO:0071350)3.63917650
102polyamine metabolic process (GO:0006595)3.57688367
103pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.57514253
104positive regulation of cell killing (GO:0031343)3.57128796
105regulation of activation of Janus kinase activity (GO:0010533)3.56475364
106* positive regulation of DNA recombination (GO:0045911)3.56124719
107positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.55602022
108positive regulation of natural killer cell mediated immunity (GO:0002717)3.53348510
109positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.53348510
110mucosal-associated lymphoid tissue development (GO:0048537)3.53301767
111Peyers patch development (GO:0048541)3.53301767
112tumor necrosis factor-mediated signaling pathway (GO:0033209)3.52805601
113pyrimidine nucleotide metabolic process (GO:0006220)3.52756894
114negative regulation of receptor activity (GO:2000272)3.51206120
115positive regulation of interleukin-12 production (GO:0032735)3.51188677
116positive regulation of organelle assembly (GO:1902117)3.51012471
117pyrimidine-containing compound biosynthetic process (GO:0072528)3.50871163
118folic acid metabolic process (GO:0046655)3.50316806
119oxygen transport (GO:0015671)3.49733004
120negative regulation of protein tyrosine kinase activity (GO:0061099)3.45205627
121positive regulation of T-helper 1 type immune response (GO:0002827)3.45146653
122negative regulation of alpha-beta T cell activation (GO:0046636)3.44788971
123alpha-beta T cell differentiation (GO:0046632)3.44494311
124modulation of growth of symbiont involved in interaction with host (GO:0044144)3.42755777
125regulation of growth of symbiont in host (GO:0044126)3.42755777
126negative regulation of growth of symbiont in host (GO:0044130)3.42755777
127negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.42755777
128regulation of T cell cytokine production (GO:0002724)3.41791417
129negative regulation of cytokine production involved in immune response (GO:0002719)3.40010184
130regulation of T cell migration (GO:2000404)3.39689593
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39592162
132positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39206615
133tRNA aminoacylation for protein translation (GO:0006418)3.37765730
134ribonucleoprotein complex biogenesis (GO:0022613)3.36809863
135tRNA aminoacylation (GO:0043039)3.34857164
136amino acid activation (GO:0043038)3.34857164
137lung lobe morphogenesis (GO:0060463)3.34364651
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31918421
139antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31918421
140regulation of macrophage derived foam cell differentiation (GO:0010743)3.29171379
141T cell costimulation (GO:0031295)3.28893991
142negative regulation of cell killing (GO:0031342)3.28236646
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28236646
144regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.27831418
145dendritic cell differentiation (GO:0097028)3.26157926
146hormone catabolic process (GO:0042447)3.26079600
147regulation of interleukin-12 production (GO:0032655)3.25887481
148pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.25333752
149positive regulation of DNA replication (GO:0045740)3.24408918
150* regulation of isotype switching (GO:0045191)3.23599605
151negative regulation of T cell differentiation in thymus (GO:0033085)3.23524238
152lymphocyte costimulation (GO:0031294)3.23019120
153regulation of heat generation (GO:0031650)3.21172620
154regulation of interleukin-2 biosynthetic process (GO:0045076)3.19676121
155embryonic placenta development (GO:0001892)3.17016316
156ER overload response (GO:0006983)3.13239549
157positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.03213958
158pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03148064
159COPII vesicle coating (GO:0048208)3.01761418
160guanosine-containing compound biosynthetic process (GO:1901070)3.00343070
161positive regulation of triglyceride biosynthetic process (GO:0010867)2.97347796
162ribosomal small subunit assembly (GO:0000028)2.92418975
163triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81764181
164rRNA processing (GO:0006364)2.81088630
165transcription from mitochondrial promoter (GO:0006390)2.80170692
166regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.77051480
167nucleoside diphosphate phosphorylation (GO:0006165)2.72269859
168postsynaptic membrane organization (GO:0001941)2.70068393
169ribosome assembly (GO:0042255)2.65484244
170viral protein processing (GO:0019082)2.64112613
171rRNA metabolic process (GO:0016072)2.63672897
172pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.62070445
173protein export from nucleus (GO:0006611)2.61755969
174positive regulation of macrophage differentiation (GO:0045651)2.60612663
175regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.60373841
176natural killer cell differentiation (GO:0001779)2.60204632
177positive regulation of T-helper cell differentiation (GO:0045624)2.58487348
178pyrimidine nucleoside metabolic process (GO:0006213)2.57603413
179negative regulation of acute inflammatory response (GO:0002674)2.56979991
180regulation of T cell mediated cytotoxicity (GO:0001914)2.54782682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.84400276
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.30750597
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.30692296
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.91183979
5E2F7_22180533_ChIP-Seq_HELA_Human4.59995857
6NOTCH1_21737748_ChIP-Seq_TLL_Human4.49005386
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.25996348
8STAT4_19710469_ChIP-ChIP_TH1__Mouse4.21193024
9EGR1_19374776_ChIP-ChIP_THP-1_Human4.19459341
10MYC_22102868_ChIP-Seq_BL_Human3.70140053
11RUNX_20019798_ChIP-Seq_JUKART_Human3.65812525
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.41159767
13SMAD_19615063_ChIP-ChIP_OVARY_Human3.39821483
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29877617
15GATA1_22025678_ChIP-Seq_K562_Human3.21743199
16RBPJ_22232070_ChIP-Seq_NCS_Mouse3.18773420
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02685104
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.92342201
19MYB_26560356_Chip-Seq_TH2_Human2.91712583
20* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.84712425
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.79703267
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66366995
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61777357
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61037769
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56658699
26MAF_26560356_Chip-Seq_TH1_Human2.54696099
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.53732412
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52701157
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45246178
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.41100710
31MYB_26560356_Chip-Seq_TH1_Human2.32268725
32* TAF15_26573619_Chip-Seq_HEK293_Human2.19945233
33EWS_26573619_Chip-Seq_HEK293_Human2.18104936
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14127952
35GATA3_27048872_Chip-Seq_THYMUS_Human2.12513199
36STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04657976
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03889693
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03833545
39UTX_26944678_Chip-Seq_JUKART_Human2.02240477
40TTF2_22483619_ChIP-Seq_HELA_Human1.99760451
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99591758
42ZNF274_21170338_ChIP-Seq_K562_Hela1.96810508
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96683279
44LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96466581
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89775942
46MAF_26560356_Chip-Seq_TH2_Human1.87793413
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87339006
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82935557
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82195781
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82073090
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.80746830
52TCF7_22412390_ChIP-Seq_EML_Mouse1.73490321
53EGR1_19032775_ChIP-ChIP_M12_Human1.71276812
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68110290
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67835495
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64020549
57KDM2B_26808549_Chip-Seq_DND41_Human1.60339938
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59137448
59CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.58995053
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52726512
61DCP1A_22483619_ChIP-Seq_HELA_Human1.50499670
62TP53_16413492_ChIP-PET_HCT116_Human1.47264972
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.45939008
64VDR_21846776_ChIP-Seq_THP-1_Human1.45901751
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45277185
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43757559
67VDR_24763502_ChIP-Seq_THP-1_Human1.43699141
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42498866
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41981106
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.38918869
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37912379
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37551268
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37013554
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34556656
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.32663949
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.31400848
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.31399224
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.31151890
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28474491
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26191151
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25271958
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.23734137
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23160359
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22789032
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22724706
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21001505
87* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20972907
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20238308
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19548367
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18950148
91PU_27001747_Chip-Seq_BMDM_Mouse1.16228479
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15481349
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.13813400
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.12081779
95AR_21909140_ChIP-Seq_LNCAP_Human1.11205680
96P300_18555785_Chip-Seq_ESCs_Mouse1.09866450
97VDR_24787735_ChIP-Seq_THP-1_Human1.09827053
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09047111
99* KLF4_18555785_Chip-Seq_ESCs_Mouse1.08740460
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08502145
101GATA3_26560356_Chip-Seq_TH2_Human1.08409602
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08347370
103* IRF8_27001747_Chip-Seq_BMDM_Mouse1.06407929
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06176699
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05576276
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05257593
107P53_21459846_ChIP-Seq_SAOS-2_Human1.04690490
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04579458
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04269477
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03556308
111VDR_23849224_ChIP-Seq_CD4+_Human1.03322269
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01996555
113ERA_21632823_ChIP-Seq_H3396_Human1.01474817
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.99919401
115SPI1_23547873_ChIP-Seq_NB4_Human0.99883883
116ELK1_19687146_ChIP-ChIP_HELA_Human0.97811596
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96459855
118ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96372760
119* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95322710
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94128511
121MYC_18940864_ChIP-ChIP_HL60_Human0.93908619
122NANOG_19829295_ChIP-Seq_ESCs_Human0.92664603
123SOX2_19829295_ChIP-Seq_ESCs_Human0.92664603
124ZNF263_19887448_ChIP-Seq_K562_Human0.91856272
125CLOCK_20551151_ChIP-Seq_293T_Human0.90993497
126MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90939439
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88853020
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87512283
129RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87327374
130CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86831714
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86257103
132* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85526649
133TP53_18474530_ChIP-ChIP_U2OS_Human0.85187466
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84113922
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82210708
136GBX2_23144817_ChIP-Seq_PC3_Human0.81967290
137ELF5_23300383_ChIP-Seq_T47D_Human0.80891566
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.80332313
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.80287321
140MYC_19829295_ChIP-Seq_ESCs_Human0.79819356
141KDM5A_27292631_Chip-Seq_BREAST_Human0.77754046
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77745331
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75868280
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75325882
145RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74386029
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74346001
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73597731
148IRF8_21731497_ChIP-ChIP_J774_Mouse0.73234621
149* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72278937
150ATF3_27146783_Chip-Seq_COLON_Human0.71188044
151CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71079845
152SPI1_23127762_ChIP-Seq_K562_Human0.68436277
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.68057307
154NCOR1_26117541_ChIP-Seq_K562_Human0.67778555
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66090334
156SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65297932
157FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.64262527
158GATA1_19941827_ChIP-Seq_MEL86_Mouse0.64057001
159FOXP3_21729870_ChIP-Seq_TREG_Human0.63663264
160XRN2_22483619_ChIP-Seq_HELA_Human0.62644091
161CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62226301
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.62009835
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61530290
164VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.61294027
165UBF1/2_26484160_Chip-Seq_HMECs_Human0.61287716
166FOXM1_23109430_ChIP-Seq_U2OS_Human0.60972610
167PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60834075
168PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59768193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.98594875
2MP0000685_abnormal_immune_system4.98752432
3MP0003763_abnormal_thymus_physiology4.40469353
4MP0003436_decreased_susceptibility_to4.38781128
5MP0003786_premature_aging3.90977288
6* MP0001835_abnormal_antigen_presentation3.87072085
7MP0006292_abnormal_olfactory_placode3.86529427
8MP0009333_abnormal_splenocyte_physiolog3.78711683
9MP0003303_peritoneal_inflammation3.44575705
10MP0003866_abnormal_defecation3.20902021
11MP0004147_increased_porphyrin_level3.04911828
12MP0004782_abnormal_surfactant_physiolog2.91088034
13MP0001790_abnormal_immune_system2.88212298
14MP0005387_immune_system_phenotype2.88212298
15MP0002736_abnormal_nociception_after2.84483100
16MP0005000_abnormal_immune_tolerance2.84170970
17* MP0002405_respiratory_system_inflammati2.79983894
18MP0009785_altered_susceptibility_to2.71613661
19MP0001800_abnormal_humoral_immune2.68581259
20MP0003329_amyloid_beta_deposits2.65266641
21MP0002234_abnormal_pharynx_morphology2.54489977
22MP0005670_abnormal_white_adipose2.54209117
23* MP0000604_amyloidosis2.53917086
24MP0006082_CNS_inflammation2.45533574
25MP0003878_abnormal_ear_physiology2.33130559
26MP0005377_hearing/vestibular/ear_phenot2.33130559
27MP0002148_abnormal_hypersensitivity_rea2.31592479
28MP0002723_abnormal_immune_serum2.29882216
29MP0004510_myositis2.24758822
30MP0001873_stomach_inflammation2.21849601
31MP0005025_abnormal_response_to2.20338745
32MP0001958_emphysema2.19847014
33* MP0002398_abnormal_bone_marrow2.19010963
34MP0003656_abnormal_erythrocyte_physiolo2.18772713
35MP0002166_altered_tumor_susceptibility2.17492479
36MP0008057_abnormal_DNA_replication2.13986212
37MP0010155_abnormal_intestine_physiology2.05543534
38MP0002420_abnormal_adaptive_immunity2.05472771
39* MP0003300_gastrointestinal_ulcer2.00973739
40MP0001819_abnormal_immune_cell2.00949188
41MP0000703_abnormal_thymus_morphology1.99421473
42MP0009697_abnormal_copulation1.96795124
43MP0002396_abnormal_hematopoietic_system1.95144620
44MP0001881_abnormal_mammary_gland1.91107366
45MP0001968_abnormal_touch/_nociception1.87991694
46MP0002452_abnormal_antigen_presenting1.85843304
47MP0004808_abnormal_hematopoietic_stem1.83206270
48* MP0000689_abnormal_spleen_morphology1.79764084
49MP0000716_abnormal_immune_system1.77313073
50MP0001502_abnormal_circadian_rhythm1.76992818
51MP0004885_abnormal_endolymph1.76834784
52MP0001501_abnormal_sleep_pattern1.67112760
53MP0002006_tumorigenesis1.67020130
54* MP0002722_abnormal_immune_system1.65087649
55MP0003718_maternal_effect1.57770240
56MP0001533_abnormal_skeleton_physiology1.54987686
57* MP0001845_abnormal_inflammatory_respons1.45868911
58MP0002938_white_spotting1.43101175
59* MP0002429_abnormal_blood_cell1.41619498
60MP0004133_heterotaxia1.38291208
61MP0004947_skin_inflammation1.37876617
62MP0002419_abnormal_innate_immunity1.34608243
63MP0004742_abnormal_vestibular_system1.32543649
64MP0010386_abnormal_urinary_bladder1.31204018
65MP0005423_abnormal_somatic_nervous1.30667437
66MP0002837_dystrophic_cardiac_calcinosis1.30480449
67MP0002933_joint_inflammation1.26267010
68MP0003724_increased_susceptibility_to1.24718439
69MP0010030_abnormal_orbit_morphology1.20959848
70MP0008872_abnormal_physiological_respon1.18923835
71MP0000678_abnormal_parathyroid_gland1.18155247
72MP0002138_abnormal_hepatobiliary_system1.18103878
73MP0003567_abnormal_fetal_cardiomyocyte1.16859993
74MP0008961_abnormal_basal_metabolism1.14495737
75MP0004145_abnormal_muscle_electrophysio1.12354105
76MP0003959_abnormal_lean_body1.09600345
77MP0001440_abnormal_grooming_behavior1.08418834
78MP0001984_abnormal_olfaction1.07763563
79MP0010307_abnormal_tumor_latency1.03134475
80MP0001661_extended_life_span1.02805409
81MP0009764_decreased_sensitivity_to1.02301801
82MP0004036_abnormal_muscle_relaxation1.01708371
83MP0000627_abnormal_mammary_gland1.01653252
84MP0002132_abnormal_respiratory_system1.00199045
85MP0005388_respiratory_system_phenotype0.98043567
86MP0002133_abnormal_respiratory_system0.98043567
87MP0001727_abnormal_embryo_implantation0.95237725
88MP0003879_abnormal_hair_cell0.93380086
89MP0003448_altered_tumor_morphology0.90733688
90MP0005166_decreased_susceptibility_to0.87524075
91MP0005165_increased_susceptibility_to0.86166889
92MP0000490_abnormal_crypts_of0.86106311
93* MP0001853_heart_inflammation0.85022402
94MP0005464_abnormal_platelet_physiology0.83456335
95MP0001293_anophthalmia0.82856308
96MP0001188_hyperpigmentation0.82466439
97MP0005636_abnormal_mineral_homeostasis0.81954515
98MP0008789_abnormal_olfactory_epithelium0.80729316
99MP0002019_abnormal_tumor_incidence0.79939419
100MP0002998_abnormal_bone_remodeling0.79871798
101MP0005390_skeleton_phenotype0.78091194
102MP0009053_abnormal_anal_canal0.77986233
103MP0001663_abnormal_digestive_system0.77884061
104MP0003119_abnormal_digestive_system0.77642204
105MP0000049_abnormal_middle_ear0.77436627
106MP0004142_abnormal_muscle_tone0.77243096
107MP0002282_abnormal_trachea_morphology0.76039014
108MP0003795_abnormal_bone_structure0.73193868
109* MP0000609_abnormal_liver_physiology0.72312110
110MP0002877_abnormal_melanocyte_morpholog0.72024142
111MP0008469_abnormal_protein_level0.71632277
112MP0002249_abnormal_larynx_morphology0.70901058
113MP0003938_abnormal_ear_development0.69359392
114MP0001851_eye_inflammation0.68783732
115MP0005076_abnormal_cell_differentiation0.68075402
116MP0000467_abnormal_esophagus_morphology0.67674092
117MP0000858_altered_metastatic_potential0.66477828
118MP0008995_early_reproductive_senescence0.64759636
119MP0001919_abnormal_reproductive_system0.62802131
120MP0005395_other_phenotype0.61224503
121MP0004381_abnormal_hair_follicle0.60953814
122MP0003453_abnormal_keratinocyte_physiol0.60075865
123MP0009765_abnormal_xenobiotic_induced0.58961105
124MP0002272_abnormal_nervous_system0.57755375
125MP0003646_muscle_fatigue0.56727607
126MP0003633_abnormal_nervous_system0.56557492
127MP0000747_muscle_weakness0.55808518
128MP0006072_abnormal_retinal_apoptosis0.54927960
129MP0001485_abnormal_pinna_reflex0.54505382
130MP0003693_abnormal_embryo_hatching0.53999831
131MP0001545_abnormal_hematopoietic_system0.52775358
132MP0005397_hematopoietic_system_phenotyp0.52775358
133MP0002135_abnormal_kidney_morphology0.52518278
134MP0002751_abnormal_autonomic_nervous0.52364099
135MP0009763_increased_sensitivity_to0.52047292
136* MP0000465_gastrointestinal_hemorrhage0.52021842
137MP0004957_abnormal_blastocyst_morpholog0.51737950
138MP0009278_abnormal_bone_marrow0.51364423
139MP0000598_abnormal_liver_morphology0.43637383
140MP0001348_abnormal_lacrimal_gland0.43457511
141MP0003936_abnormal_reproductive_system0.42133623
142MP0004197_abnormal_fetal_growth/weight/0.41953653
143MP0000350_abnormal_cell_proliferation0.41051451
144MP0003077_abnormal_cell_cycle0.40841768
145MP0008569_lethality_at_weaning0.39065438
146MP0005647_abnormal_sex_gland0.38483587
147MP0005381_digestive/alimentary_phenotyp0.37900468
148MP0002136_abnormal_kidney_physiology0.35742538
149MP0001765_abnormal_ion_homeostasis0.33610390
150MP0002089_abnormal_postnatal_growth/wei0.32305550
151MP0005310_abnormal_salivary_gland0.29943288
152MP0002083_premature_death0.27257850
153MP0001216_abnormal_epidermal_layer0.27099591
154MP0002088_abnormal_embryonic_growth/wei0.26396578

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)9.49768005
2Increased density of long bones (HP:0006392)8.06920486
3IgA deficiency (HP:0002720)7.33824377
4T lymphocytopenia (HP:0005403)6.35760210
5Abnormality of T cell number (HP:0011839)6.19012067
6Persistence of primary teeth (HP:0006335)5.99285335
73-Methylglutaconic aciduria (HP:0003535)5.97111245
8Abnormality of T cells (HP:0002843)5.79866462
9Microvesicular hepatic steatosis (HP:0001414)5.52961521
10Poor speech (HP:0002465)5.45916416
11Gastrointestinal infarctions (HP:0005244)5.36857943
12Abnormality of T cell physiology (HP:0011840)5.11535416
13Absent rod-and cone-mediated responses on ERG (HP:0007688)5.06638752
14IgG deficiency (HP:0004315)4.93164344
15Thrombocytosis (HP:0001894)4.88702628
16Elevated erythrocyte sedimentation rate (HP:0003565)4.44284961
17Bicuspid aortic valve (HP:0001647)4.11362396
18Fatigue (HP:0012378)4.08185116
19Acute lymphatic leukemia (HP:0006721)4.07782487
20Severe combined immunodeficiency (HP:0004430)4.01658598
21Amaurosis fugax (HP:0100576)3.95524328
22Congenital, generalized hypertrichosis (HP:0004540)3.88419143
23Chronic diarrhea (HP:0002028)3.87498792
24Bile duct proliferation (HP:0001408)3.80197332
25Abnormal biliary tract physiology (HP:0012439)3.80197332
26Myocardial infarction (HP:0001658)3.74252046
27Arterial thrombosis (HP:0004420)3.72463545
28Eczematoid dermatitis (HP:0000976)3.72234718
29Dyschromatopsia (HP:0007641)3.69836050
30Recurrent fungal infections (HP:0002841)3.62800631
31Sensorimotor neuropathy (HP:0007141)3.62372520
32Nasal polyposis (HP:0100582)3.59322737
33Neoplasm of the peripheral nervous system (HP:0100007)3.53823637
34Joint swelling (HP:0001386)3.50958303
35Panhypogammaglobulinemia (HP:0003139)3.47608954
36Hypergammaglobulinemia (HP:0010702)3.46136278
37Gingivitis (HP:0000230)3.45745679
38Combined immunodeficiency (HP:0005387)3.40350760
39Recurrent viral infections (HP:0004429)3.36035734
40Chest pain (HP:0100749)3.34610790
41Polycythemia (HP:0001901)3.33517320
42Broad face (HP:0000283)3.33440358
43Hepatitis (HP:0012115)3.24725399
44Testicular atrophy (HP:0000029)3.23775871
45Peritonitis (HP:0002586)3.17337267
46Abnormality of B cell number (HP:0010975)3.14026479
47B lymphocytopenia (HP:0010976)3.14026479
48Constricted visual fields (HP:0001133)3.09780671
49Mediastinal lymphadenopathy (HP:0100721)3.08549166
50Abnormality of the peritoneum (HP:0002585)3.06791474
51Back pain (HP:0003418)3.03278038
52Abnormality of the nasal septum (HP:0000419)2.98300809
53Type 2 muscle fiber atrophy (HP:0003554)2.97737312
54Acute myeloid leukemia (HP:0004808)2.97717024
55Somatic mutation (HP:0001428)2.96552506
56Increased hepatocellular lipid droplets (HP:0006565)2.95746261
57Abnormality of the nasal mucosa (HP:0000433)2.94508293
58Abnormal rod and cone electroretinograms (HP:0008323)2.93060351
59Oral leukoplakia (HP:0002745)2.88744929
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76648010
61Cerebral hemorrhage (HP:0001342)2.70546509
62Insomnia (HP:0100785)2.70243015
63Chronic sinusitis (HP:0011109)2.67089936
64Spontaneous abortion (HP:0005268)2.66733786
65Exertional dyspnea (HP:0002875)2.66711671
66Hyperlipoproteinemia (HP:0010980)2.63357190
67Premature loss of primary teeth (HP:0006323)2.59140954
68Rib fusion (HP:0000902)2.57863368
69Diplopia (HP:0000651)2.57540584
70Abnormality of binocular vision (HP:0011514)2.57540584
71Hepatosplenomegaly (HP:0001433)2.57075603
72Gingival bleeding (HP:0000225)2.54483071
73Bony spicule pigmentary retinopathy (HP:0007737)2.52637617
74Muscle fiber atrophy (HP:0100295)2.51987593
75Recurrent bronchitis (HP:0002837)2.50045486
76Peripheral hypomyelination (HP:0007182)2.48466429
77Delayed myelination (HP:0012448)2.48086292
78Esophageal varix (HP:0002040)2.46445575
79Abnormal ciliary motility (HP:0012262)2.45707402
80Hypoalphalipoproteinemia (HP:0003233)2.45534321
81Lipid accumulation in hepatocytes (HP:0006561)2.43199278
82Abnormal respiratory epithelium morphology (HP:0012253)2.38308630
83Abnormal respiratory motile cilium morphology (HP:0005938)2.38308630
84Vacuolated lymphocytes (HP:0001922)2.36672599
85Aplastic anemia (HP:0001915)2.36279427
86Fatigable weakness (HP:0003473)2.32654735
87Abnormality of the neuromuscular junction (HP:0003398)2.32654735
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31213182
89Horseshoe kidney (HP:0000085)2.28923560
90Nephronophthisis (HP:0000090)2.28274597
91Chorioretinal atrophy (HP:0000533)2.27170424
92Chronic otitis media (HP:0000389)2.24767295
93Agammaglobulinemia (HP:0004432)2.24514398
94Thrombophlebitis (HP:0004418)2.22000622
95Leukocytosis (HP:0001974)2.21093483
96Acute hepatic failure (HP:0006554)2.19738422
97Confusion (HP:0001289)2.18002435
98Basal cell carcinoma (HP:0002671)2.17973681
99Premature graying of hair (HP:0002216)2.17327407
100Elfin facies (HP:0004428)2.16768260
101Upper limb muscle weakness (HP:0003484)2.16002075
102Lymphoma (HP:0002665)2.15422736
103Malnutrition (HP:0004395)2.09389600
104Pancytopenia (HP:0001876)2.08045712
105Vertebral fusion (HP:0002948)2.07953721
106Thyroiditis (HP:0100646)2.03915396
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03619564
108Hypoplasia of the pons (HP:0012110)2.03215318
109Abnormal delayed hypersensitivity skin test (HP:0002963)2.02963498
110Septate vagina (HP:0001153)2.00559944
111Stomatitis (HP:0010280)13.7262726
112Pulmonary infiltrates (HP:0002113)1.99970667
113Increased intramyocellular lipid droplets (HP:0012240)1.90968168
114Neoplasm of the tracheobronchial system (HP:0100552)1.90837345
115Alveolar cell carcinoma (HP:0006519)1.90669315
116Depressed nasal tip (HP:0000437)1.88710470
117Renal Fanconi syndrome (HP:0001994)1.86292994
118Vasculitis (HP:0002633)1.85631032
119Abnormality of the carotid arteries (HP:0005344)1.85439901
120Malignant hyperthermia (HP:0002047)1.83881361
121Nonprogressive disorder (HP:0003680)1.83637313
122Hyperphosphaturia (HP:0003109)1.83232415
123Pallor (HP:0000980)1.81201971
124Abnormal number of incisors (HP:0011064)1.80368226
125Increased muscle lipid content (HP:0009058)1.79769214
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78921645
127Spastic paraparesis (HP:0002313)1.78321383
128Portal hypertension (HP:0001409)1.77548152
129IgM deficiency (HP:0002850)1.74458504
130Abnormality of the pons (HP:0007361)1.74024191
131Renovascular hypertension (HP:0100817)1.73243566
132Broad-based gait (HP:0002136)1.73064112
133Hyperacusis (HP:0010780)1.72264082
134Squamous cell carcinoma (HP:0002860)1.71231994
135Abnormal respiratory motile cilium physiology (HP:0012261)1.70987160
136Ectopic kidney (HP:0000086)1.70772499
137Overriding aorta (HP:0002623)1.70665341
138Abnormality of the prostate (HP:0008775)1.69648024
139Abnormality of primary teeth (HP:0006481)1.69597655
140Entropion (HP:0000621)1.69302024
141Submucous cleft hard palate (HP:0000176)1.69002987
142Abnormality of the anterior horn cell (HP:0006802)1.68746852
143Degeneration of anterior horn cells (HP:0002398)1.68746852
144Epistaxis (HP:0000421)1.67657971
145Bilateral microphthalmos (HP:0007633)1.67402968
146Spondylolisthesis (HP:0003302)1.67068002
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.66685657
148Eosinophilia (HP:0001880)1.66233278
149Encephalitis (HP:0002383)1.65890550
150Cutaneous melanoma (HP:0012056)1.65423187
151Abnormality of the frontal sinuses (HP:0002687)1.65275713
152Chromsome breakage (HP:0040012)1.65081956
153Colitis (HP:0002583)1.65025983
154Acrocyanosis (HP:0001063)1.63656814
155Lymphopenia (HP:0001888)1.62498192
156Dysmetric saccades (HP:0000641)1.62416470
157Abnormality of eosinophils (HP:0001879)1.62031899
158Abnormality of the hepatic vasculature (HP:0006707)1.61392398
159Gastrointestinal stroma tumor (HP:0100723)1.61005862
160Segmental peripheral demyelination/remyelination (HP:0003481)1.60803181
161Pulmonary embolism (HP:0002204)1.59890517
162Rhinitis (HP:0012384)1.58131606
163Recurrent cutaneous fungal infections (HP:0011370)1.57233630
164Chronic mucocutaneous candidiasis (HP:0002728)1.57233630
165Scanning speech (HP:0002168)1.56660994
166Arthralgia (HP:0002829)1.55599685
167Mitral valve prolapse (HP:0001634)1.54482861
168Osteolytic defects of the phalanges of the hand (HP:0009771)1.54467156
169Osteolytic defects of the hand bones (HP:0009699)1.54467156
170Oligodontia (HP:0000677)1.53246883
171Nausea (HP:0002018)1.52353541
172Poikiloderma (HP:0001029)1.51937670
173Urinary urgency (HP:0000012)1.50487778
174Neutropenia (HP:0001875)1.49256499
175Thoracolumbar scoliosis (HP:0002944)1.47338316
176Vertigo (HP:0002321)1.46965854
1772-3 toe syndactyly (HP:0004691)1.46153792
178Ureteral stenosis (HP:0000071)1.42374070
179Porencephaly (HP:0002132)1.40734605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PAK47.32716124
2TXK6.95571507
3MAP4K16.21671136
4ZAP704.14380562
5JAK33.61277048
6MAP3K143.20243913
7TAOK13.13865624
8MAP3K112.90251200
9ITK2.84551689
10PIM22.77973219
11TAOK22.68467371
12NEK12.38688570
13ICK2.34751115
14CHUK2.28685440
15IKBKB2.23017056
16MAP2K32.16286055
17MAP3K32.03862697
18PRKD32.03471820
19ADRBK21.96457002
20SIK31.94857124
21NME11.94332689
22TEC1.80117982
23MAP3K71.79851616
24MST1R1.77720527
25ZAK1.70194802
26ATR1.60247852
27GRK11.57697123
28EEF2K1.57649697
29CSK1.41793057
30BUB11.38997508
31NME21.29233380
32ACVR1B1.28821841
33LCK1.27023418
34RPS6KA41.25614288
35TSSK61.25402061
36DYRK21.14411856
37PIM11.10360679
38RAF11.09912778
39NTRK21.09208349
40HCK1.07807968
41PAK31.06676073
42ALK1.06520039
43TRIB31.05999207
44IKBKE1.05126822
45SYK1.04461761
46BTK1.02573934
47RPS6KA61.01793570
48MAP3K131.00781212
49TBK10.99811758
50PLK10.96883896
51BMPR20.94114011
52PAK20.93290780
53RPS6KC10.92060484
54RPS6KL10.92060484
55PRKCH0.90660936
56FGFR40.87224430
57UHMK10.86060002
58FGFR10.85630883
59STK100.85370105
60CDK120.85330255
61TYK20.83584963
62SIK10.81640490
63JAK20.78373226
64MAP3K50.77481523
65RPS6KA50.76293153
66NEK20.75933170
67MAP3K80.74639805
68PRKCQ0.73438968
69MAP3K100.72029478
70EIF2AK30.67930093
71PKN20.67052361
72MAP3K10.65621898
73RPS6KA10.64274995
74PASK0.61921442
75FGFR30.61289023
76ROCK20.60682191
77LYN0.59596948
78NUAK10.59120051
79JAK10.59073734
80ERBB30.59057588
81ERBB40.55907731
82LRRK20.55790504
83MAP3K40.55596525
84STK40.55336090
85FES0.55243450
86TYRO30.53557705
87TESK10.52590013
88GSK3A0.51805126
89PDK20.50059769
90GSK3B0.49531926
91WNK30.49479394
92MST40.49077144
93EIF2AK20.46865451
94MAPK140.46628436
95EIF2AK10.44381577
96PHKG20.43700692
97PHKG10.43700692
98INSRR0.43665606
99PDGFRB0.43326884
100MELK0.43032261
101ATM0.42514525
102CDK70.41570063
103CHEK10.40882789
104SRPK10.39473960
105MAP2K60.38244627
106MAPK100.37881550
107MKNK20.35819464
108SMG10.35782777
109CSNK2A10.35584421
110IGF1R0.35082247
111OBSCN0.34774550
112INSR0.34292251
113CDK40.34289601
114PDK10.32692912
115NLK0.32692778
116TGFBR10.29597266
117RPS6KA30.29017483
118EGFR0.28772779
119MAPKAPK20.28484536
120SCYL20.27786637
121CDK90.27470175
122CSNK1A1L0.26761818
123CDK60.26604618
124CDK10.26536976
125BRD40.26240110
126PRKCE0.25026540
127ERN10.24790801
128PLK30.24446197
129EPHB10.24380020
130PRKD20.24048946
131ABL10.23879390
132PRKDC0.23873664
133BMPR1B0.23824563
134CSNK2A20.23707631
135FRK0.23127091
136MAPK30.22135687
137CSNK1E0.21926925
138MAPK130.21822691
139ERBB20.21280095
140MAP2K70.20441337
141WNK10.19957894
142RPS6KB20.19504362
143SGK10.19133578
144CSNK1D0.18428256
145PRKCB0.17999310
146IRAK40.17556367
147RPS6KB10.16019892
148MTOR0.15457368
149GRK60.15417593
150SIK20.15404608
151MAPK80.15159204
152EPHA30.14862822
153MKNK10.14263681
154PTK60.13941264
155KDR0.13183747
156AURKB0.12794268

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053108.38651554
2* Allograft rejection_Homo sapiens_hsa053305.20121112
3Basal transcription factors_Homo sapiens_hsa030224.05326609
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.33999477
5* T cell receptor signaling pathway_Homo sapiens_hsa046603.27300571
6* Type I diabetes mellitus_Homo sapiens_hsa049403.04765449
7Primary immunodeficiency_Homo sapiens_hsa053402.90457053
8Protein export_Homo sapiens_hsa030602.86236834
9Proteasome_Homo sapiens_hsa030502.58419184
10* Graft-versus-host disease_Homo sapiens_hsa053322.54429352
11Hematopoietic cell lineage_Homo sapiens_hsa046402.50513995
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.49591640
13* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49384753
14* Autoimmune thyroid disease_Homo sapiens_hsa053202.48184558
15* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.26470398
16* Jak-STAT signaling pathway_Homo sapiens_hsa046301.95466288
17Dorso-ventral axis formation_Homo sapiens_hsa043201.94959161
18Pyrimidine metabolism_Homo sapiens_hsa002401.87056632
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84687052
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77984819
21Leishmaniasis_Homo sapiens_hsa051401.75472009
22TNF signaling pathway_Homo sapiens_hsa046681.69521665
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63698631
24* Intestinal immune network for IgA production_Homo sapiens_hsa046721.60781378
25* Measles_Homo sapiens_hsa051621.53781237
26Toxoplasmosis_Homo sapiens_hsa051451.52994659
27Malaria_Homo sapiens_hsa051441.48630179
28Viral myocarditis_Homo sapiens_hsa054161.47046309
29Base excision repair_Homo sapiens_hsa034101.46846326
30Antigen processing and presentation_Homo sapiens_hsa046121.41553904
31Osteoclast differentiation_Homo sapiens_hsa043801.36719817
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27517135
33Nucleotide excision repair_Homo sapiens_hsa034201.27442823
34Herpes simplex infection_Homo sapiens_hsa051681.24744177
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22397842
36Rheumatoid arthritis_Homo sapiens_hsa053231.19997222
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18175318
38Prolactin signaling pathway_Homo sapiens_hsa049171.13807735
39Legionellosis_Homo sapiens_hsa051341.11100601
40Mineral absorption_Homo sapiens_hsa049781.10768503
41Acute myeloid leukemia_Homo sapiens_hsa052211.03447412
42Apoptosis_Homo sapiens_hsa042101.02378253
43Chronic myeloid leukemia_Homo sapiens_hsa052200.93596454
44Systemic lupus erythematosus_Homo sapiens_hsa053220.92013426
45Salmonella infection_Homo sapiens_hsa051320.91774152
46* HTLV-I infection_Homo sapiens_hsa051660.91439897
47Hepatitis B_Homo sapiens_hsa051610.90862329
48* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86613411
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85863624
50Regulation of autophagy_Homo sapiens_hsa041400.85645425
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83034314
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.82457936
53Chemokine signaling pathway_Homo sapiens_hsa040620.81712222
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81480614
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80992585
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.80420453
57Amoebiasis_Homo sapiens_hsa051460.79731907
58African trypanosomiasis_Homo sapiens_hsa051430.77151873
59Viral carcinogenesis_Homo sapiens_hsa052030.74163412
60B cell receptor signaling pathway_Homo sapiens_hsa046620.73690469
61One carbon pool by folate_Homo sapiens_hsa006700.69727752
62Pertussis_Homo sapiens_hsa051330.69263200
63Oxidative phosphorylation_Homo sapiens_hsa001900.67836754
64Nicotine addiction_Homo sapiens_hsa050330.66789202
65Influenza A_Homo sapiens_hsa051640.66210510
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63349082
67Epstein-Barr virus infection_Homo sapiens_hsa051690.63052955
68Tuberculosis_Homo sapiens_hsa051520.62399129
69Circadian rhythm_Homo sapiens_hsa047100.61878880
70Small cell lung cancer_Homo sapiens_hsa052220.60052360
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55707880
72Shigellosis_Homo sapiens_hsa051310.55241126
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53115166
74RNA transport_Homo sapiens_hsa030130.51943404
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50513275
76Sulfur metabolism_Homo sapiens_hsa009200.50150907
77Spliceosome_Homo sapiens_hsa030400.48174561
78MAPK signaling pathway_Homo sapiens_hsa040100.47752203
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.47031371
80Pancreatic cancer_Homo sapiens_hsa052120.46237761
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43604559
82Hepatitis C_Homo sapiens_hsa051600.42317412
83Vitamin digestion and absorption_Homo sapiens_hsa049770.42263775
84Ribosome_Homo sapiens_hsa030100.42193089
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.38961090
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35582205
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.35565990
88Cardiac muscle contraction_Homo sapiens_hsa042600.35033712
89Parkinsons disease_Homo sapiens_hsa050120.34310099
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33573175
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32611106
92Vitamin B6 metabolism_Homo sapiens_hsa007500.30405027
93MicroRNAs in cancer_Homo sapiens_hsa052060.27621287
94HIF-1 signaling pathway_Homo sapiens_hsa040660.27255344
95Purine metabolism_Homo sapiens_hsa002300.26323019
96Fructose and mannose metabolism_Homo sapiens_hsa000510.25833278
97Insulin resistance_Homo sapiens_hsa049310.24894943
98Cocaine addiction_Homo sapiens_hsa050300.23312083
99Fanconi anemia pathway_Homo sapiens_hsa034600.23075322
100mTOR signaling pathway_Homo sapiens_hsa041500.21665236
101Olfactory transduction_Homo sapiens_hsa047400.19919789
102Alzheimers disease_Homo sapiens_hsa050100.19178373
103RNA polymerase_Homo sapiens_hsa030200.18869110
104Taste transduction_Homo sapiens_hsa047420.18033427
105mRNA surveillance pathway_Homo sapiens_hsa030150.17561232
106Colorectal cancer_Homo sapiens_hsa052100.16287492
107Complement and coagulation cascades_Homo sapiens_hsa046100.15572226
108RNA degradation_Homo sapiens_hsa030180.14894282
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.13395697
110VEGF signaling pathway_Homo sapiens_hsa043700.13140215
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.12920675
112PPAR signaling pathway_Homo sapiens_hsa033200.12690840
113TGF-beta signaling pathway_Homo sapiens_hsa043500.12616887
114Retinol metabolism_Homo sapiens_hsa008300.12586212
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.12434625
116Thyroid cancer_Homo sapiens_hsa052160.12302870
117Huntingtons disease_Homo sapiens_hsa050160.12228101
118Prostate cancer_Homo sapiens_hsa052150.10970681
119* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10842212
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09782215
121Type II diabetes mellitus_Homo sapiens_hsa049300.07841118
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07671210
123Phototransduction_Homo sapiens_hsa047440.06913561
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06774347
125Peroxisome_Homo sapiens_hsa041460.04535175
126Platelet activation_Homo sapiens_hsa046110.03276787
127p53 signaling pathway_Homo sapiens_hsa041150.03075599
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.02513514
129Insulin signaling pathway_Homo sapiens_hsa049100.02127728
130Linoleic acid metabolism_Homo sapiens_hsa005910.01643842
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.01447543
132ErbB signaling pathway_Homo sapiens_hsa040120.00621543
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.00525829
134Pathways in cancer_Homo sapiens_hsa05200-0.0599497
135Proteoglycans in cancer_Homo sapiens_hsa05205-0.0524539
136Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0494019
137Lysine degradation_Homo sapiens_hsa00310-0.0446963
138Calcium signaling pathway_Homo sapiens_hsa04020-0.0444617
139Metabolic pathways_Homo sapiens_hsa01100-0.0335963
140Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0304314
141Staphylococcus aureus infection_Homo sapiens_hsa05150-0.0277495
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0232804
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0169087
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0149394
145Other glycan degradation_Homo sapiens_hsa00511-0.0111766

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