IL20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.47256888
2regulation of female gonad development (GO:2000194)9.27732563
3piRNA metabolic process (GO:0034587)9.20888909
4establishment of skin barrier (GO:0061436)8.75096748
5attachment of spindle microtubules to kinetochore (GO:0008608)7.40861378
6meiotic cell cycle (GO:0051321)7.02124163
7regulation of cell proliferation involved in kidney development (GO:1901722)6.93387408
8female gamete generation (GO:0007292)6.86199072
9mitotic metaphase plate congression (GO:0007080)6.52310819
10desmosome organization (GO:0002934)6.30418089
11DNA methylation involved in gamete generation (GO:0043046)6.02263277
12mitotic chromosome condensation (GO:0007076)5.97085408
13regulation of meiosis (GO:0040020)5.95822492
14ear development (GO:0043583)5.93261504
15multicellular organismal water homeostasis (GO:0050891)5.81323096
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.49642966
17metaphase plate congression (GO:0051310)5.45787343
18negative regulation of meiosis (GO:0045835)5.41510269
19histone H2A monoubiquitination (GO:0035518)5.32804593
20intestinal epithelial cell development (GO:0060576)5.27138580
21male meiosis (GO:0007140)5.25727239
22mitotic sister chromatid segregation (GO:0000070)5.19969210
23establishment of chromosome localization (GO:0051303)5.14746536
24meiotic chromosome segregation (GO:0045132)5.03410485
25hepatocyte apoptotic process (GO:0097284)5.02670976
26protein K6-linked ubiquitination (GO:0085020)4.98370483
27regulation of exit from mitosis (GO:0007096)4.86968798
28negative regulation of smooth muscle cell differentiation (GO:0051151)4.84355201
29regulation of acrosome reaction (GO:0060046)4.82601669
30histone H2A ubiquitination (GO:0033522)4.80760620
31oocyte maturation (GO:0001556)4.79145921
32water homeostasis (GO:0030104)4.71278067
33keratinocyte development (GO:0003334)4.69250540
34regulation of meiotic cell cycle (GO:0051445)4.63643151
35keratinocyte differentiation (GO:0030216)4.60438280
36hair cycle (GO:0042633)4.58300032
37molting cycle (GO:0042303)4.58300032
38DNA damage induced protein phosphorylation (GO:0006975)4.56106860
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.53997210
40negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.53464098
41notochord development (GO:0030903)4.47197737
42regulation of DNA methylation (GO:0044030)4.44379771
43* positive regulation of keratinocyte differentiation (GO:0045618)4.44351864
44regulation of sister chromatid cohesion (GO:0007063)4.44284755
45maturation of 5.8S rRNA (GO:0000460)4.41795240
46base-excision repair, AP site formation (GO:0006285)4.41154428
47trophectodermal cell differentiation (GO:0001829)4.38821731
48regulation of mitotic spindle organization (GO:0060236)4.37299553
49glycerophospholipid catabolic process (GO:0046475)4.36201092
50cardiac right ventricle morphogenesis (GO:0003215)4.31689082
51positive regulation of cellular amide metabolic process (GO:0034250)4.29789151
52chromatin remodeling at centromere (GO:0031055)4.27264241
53multicellular organism reproduction (GO:0032504)4.26018757
54CENP-A containing nucleosome assembly (GO:0034080)4.25292607
55negative regulation of meiotic cell cycle (GO:0051447)4.14320001
56sister chromatid segregation (GO:0000819)4.12065623
57positive regulation of glomerulus development (GO:0090193)4.10912506
58protein localization to kinetochore (GO:0034501)3.99122000
59* positive regulation of epidermis development (GO:0045684)3.98952656
60mammary gland epithelial cell proliferation (GO:0033598)3.98237329
61positive regulation of Cdc42 GTPase activity (GO:0043089)3.96931025
62DNA replication-independent nucleosome organization (GO:0034724)3.96004698
63DNA replication-independent nucleosome assembly (GO:0006336)3.96004698
64chromosome segregation (GO:0007059)3.94982179
65oogenesis (GO:0048477)3.94171309
66regulation of spindle organization (GO:0090224)3.93918360
67amyloid precursor protein catabolic process (GO:0042987)3.87863770
68outflow tract morphogenesis (GO:0003151)3.87287498
69chaperone-mediated protein transport (GO:0072321)3.87213538
70surfactant homeostasis (GO:0043129)3.85816425
71epidermal cell differentiation (GO:0009913)3.84724664
72epithelial cell differentiation involved in prostate gland development (GO:0060742)3.84254996
73cellular response to interferon-alpha (GO:0035457)3.82265144
74regulation of meiosis I (GO:0060631)3.80026493
75uterus development (GO:0060065)3.79347446
76skin morphogenesis (GO:0043589)3.78840150
77regulation of histone H3-K27 methylation (GO:0061085)3.78738994
78epithelial cell maturation (GO:0002070)3.77356889
79protein complex localization (GO:0031503)3.75735745
80histone exchange (GO:0043486)3.75224588
81pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.68588181
82spindle checkpoint (GO:0031577)3.68517300
83bundle of His cell to Purkinje myocyte communication (GO:0086069)3.65345166
84regulation of transforming growth factor beta2 production (GO:0032909)3.63603347
85DNA methylation (GO:0006306)3.62621522
86DNA alkylation (GO:0006305)3.62621522
87citrulline biosynthetic process (GO:0019240)3.62003514
88protein localization to chromosome, centromeric region (GO:0071459)3.61933204
89negative regulation of DNA-templated transcription, elongation (GO:0032785)3.60647017
90negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.60647017
91regulation of vitamin D biosynthetic process (GO:0060556)3.59383480
92regulation of retinoic acid receptor signaling pathway (GO:0048385)3.58658669
93interferon-gamma secretion (GO:0072643)3.58481182
94epidermis development (GO:0008544)3.57870926
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54618514
96gene silencing by RNA (GO:0031047)3.54342500
97* positive regulation of epidermal cell differentiation (GO:0045606)3.53292868
98kinetochore assembly (GO:0051382)3.53057077
99regulation of mammary gland epithelial cell proliferation (GO:0033599)3.52463838
100negative regulation of interferon-gamma production (GO:0032689)3.52119630
101mammary gland epithelial cell differentiation (GO:0060644)3.51276786
102ovulation cycle (GO:0042698)3.47774682
103kinetochore organization (GO:0051383)3.47474605
104female gonad development (GO:0008585)3.46462349
105linoleic acid metabolic process (GO:0043651)3.45048627
106positive regulation of chromosome segregation (GO:0051984)3.43977541
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.43909707
108regulation of chromosome segregation (GO:0051983)3.43498254
109negative regulation of cell division (GO:0051782)3.42995046
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.42787996
111regulation of RIG-I signaling pathway (GO:0039535)3.41877776
112negative regulation of reproductive process (GO:2000242)3.41468490
113chemical homeostasis within a tissue (GO:0048875)3.38876179
114cell differentiation involved in embryonic placenta development (GO:0060706)3.37801343
115protein localization to chromosome (GO:0034502)3.36966854
116negative regulation of nuclear division (GO:0051784)3.34309461
117regulation of protein localization to cell surface (GO:2000008)3.33137922
118keratinocyte proliferation (GO:0043616)3.33017247
119mitotic spindle checkpoint (GO:0071174)3.32163512
120Golgi transport vesicle coating (GO:0048200)3.28693093
121COPI coating of Golgi vesicle (GO:0048205)3.28693093
122negative regulation of hormone metabolic process (GO:0032351)3.28191743
123negative regulation of hormone biosynthetic process (GO:0032353)3.28191743
124norepinephrine metabolic process (GO:0042415)3.27208383
125positive regulation of humoral immune response (GO:0002922)3.26776855
126positive regulation of hair follicle development (GO:0051798)3.23143900
127positive regulation of hair cycle (GO:0042635)3.23143900
128cellular zinc ion homeostasis (GO:0006882)3.22967571
129branching involved in mammary gland duct morphogenesis (GO:0060444)3.20313128
130type B pancreatic cell development (GO:0003323)3.18565018
131positive regulation of megakaryocyte differentiation (GO:0045654)3.17461159
132mammary gland alveolus development (GO:0060749)3.17369584
133regulation of hypersensitivity (GO:0002883)3.17279997
134reproduction (GO:0000003)3.16586602
135face development (GO:0060324)3.13800767
136nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.12824021
137positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11405465
138positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11405465
139positive regulation of mitotic sister chromatid separation (GO:1901970)3.11405465
140branching involved in labyrinthine layer morphogenesis (GO:0060670)3.11132638
141fertilization (GO:0009566)3.10986797
142negative regulation of keratinocyte proliferation (GO:0010839)3.09729408
143chromatin assembly or disassembly (GO:0006333)3.09643869
144microtubule anchoring (GO:0034453)3.07636619
145ovarian follicle development (GO:0001541)3.07252951
146cytoskeleton-dependent cytokinesis (GO:0061640)3.07142166
147positive regulation of cholesterol efflux (GO:0010875)3.06720923
148auditory receptor cell differentiation (GO:0042491)3.06589764
149phosphatidylglycerol biosynthetic process (GO:0006655)3.02757496
150mitotic spindle assembly checkpoint (GO:0007094)3.01875429
151negative regulation of chromosome segregation (GO:0051985)3.01437705
152DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.00302170
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99992161
154mitotic nuclear envelope disassembly (GO:0007077)2.99732899
155rRNA methylation (GO:0031167)2.99492427
156negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99212745
157negative regulation of sister chromatid segregation (GO:0033046)2.99212745
158tight junction assembly (GO:0070830)2.96018221
159fatty acid elongation (GO:0030497)2.95732546
160regulation of establishment of cell polarity (GO:2000114)2.95165833
161zinc ion transmembrane transport (GO:0071577)2.94663268
162trivalent inorganic anion homeostasis (GO:0072506)2.86188899
163phosphate ion homeostasis (GO:0055062)2.86188899
164activation of MAPKKK activity (GO:0000185)2.84087435
165cardiac ventricle morphogenesis (GO:0003208)2.81675623
166regulation of glomerulus development (GO:0090192)2.81401055
167regulation of interleukin-13 production (GO:0032656)2.78281388
168T-helper cell differentiation (GO:0042093)2.77676495
169CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.77676495
170regulation of chromatin binding (GO:0035561)2.73950798
171signal transduction in absence of ligand (GO:0038034)2.73923301
172extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.73923301
173eyelid development in camera-type eye (GO:0061029)2.72306600
174amyloid precursor protein metabolic process (GO:0042982)2.71837887
175mesonephros development (GO:0001823)2.71698093
176phosphatidylinositol 3-kinase signaling (GO:0014065)2.71612534
177* regulation of epidermis development (GO:0045682)2.70274174
178ectoderm development (GO:0007398)2.70196690
179L-alpha-amino acid transmembrane transport (GO:1902475)2.67911855
180regulation of transforming growth factor beta1 production (GO:0032908)2.67599162
181regulation of establishment or maintenance of cell polarity (GO:0032878)2.67523200
182ceramide biosynthetic process (GO:0046513)2.66909700
183maternal placenta development (GO:0001893)2.66012848
184regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65730687
185oocyte development (GO:0048599)2.65658014
186maintenance of gastrointestinal epithelium (GO:0030277)2.65622511
187* regulation of keratinocyte differentiation (GO:0045616)2.63392266
188response to iron ion (GO:0010039)2.62121418
189post-embryonic morphogenesis (GO:0009886)2.62043329
190glucose 6-phosphate metabolic process (GO:0051156)2.61328787
191adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60709545
192lipoxygenase pathway (GO:0019372)2.56969218
193negative regulation of transcription by competitive promoter binding (GO:0010944)2.56074993
194phospholipid efflux (GO:0033700)2.55860186
195positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.55720683
196regulation of vitamin metabolic process (GO:0030656)2.53722662
197keratinization (GO:0031424)12.1446821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human6.38498014
2ESR2_21235772_ChIP-Seq_MCF-7_Human5.69556192
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.46012544
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.38119957
5ESR1_15608294_ChIP-ChIP_MCF-7_Human5.09866968
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.88677089
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.73346241
8E2F7_22180533_ChIP-Seq_HELA_Human3.72412556
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.43664334
10AR_21909140_ChIP-Seq_LNCAP_Human3.37408907
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33547438
12KAP1_22055183_ChIP-Seq_ESCs_Mouse3.31744546
13EZH2_22144423_ChIP-Seq_EOC_Human3.31016410
14HIF1A_21447827_ChIP-Seq_MCF-7_Human3.24983717
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04309199
16RUNX1_27514584_Chip-Seq_MCF-7_Human2.95753839
17RACK7_27058665_Chip-Seq_MCF-7_Human2.81273081
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.74918815
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.69938965
20* GATA3_24758297_ChIP-Seq_MCF-7_Human2.64767082
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.49434514
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.35809262
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35345651
24ZNF263_19887448_ChIP-Seq_K562_Human2.34826353
25IGF1R_20145208_ChIP-Seq_DFB_Human2.32630411
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23870550
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21650178
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.21134374
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.21009946
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14233127
31AHR_22903824_ChIP-Seq_MCF-7_Human1.92236175
32ELF5_23300383_ChIP-Seq_T47D_Human1.90624566
33CLOCK_20551151_ChIP-Seq_293T_Human1.90315174
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83388596
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83388596
36EWS_26573619_Chip-Seq_HEK293_Human1.79884040
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.79508172
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72208679
39LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71950209
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71493505
41* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.70001114
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67895656
43MYC_18940864_ChIP-ChIP_HL60_Human1.67519108
44RNF2_27304074_Chip-Seq_NSC_Mouse1.66954026
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65862734
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64522540
47PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63939818
48FUS_26573619_Chip-Seq_HEK293_Human1.63869004
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63783885
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63235253
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58865980
52ATF3_27146783_Chip-Seq_COLON_Human1.58458758
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56441922
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52644269
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49307298
56RUNX1_26923725_Chip-Seq_HPCs_Mouse1.46585020
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45822086
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45499798
59STAT1_17558387_ChIP-Seq_HELA_Human1.45069283
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43520093
61TCF7_22412390_ChIP-Seq_EML_Mouse1.42882681
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41178796
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41120890
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.39777879
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39197742
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36709944
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36016967
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35318011
69GATA6_25053715_ChIP-Seq_YYC3_Human1.35134610
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34026544
71STAT3_23295773_ChIP-Seq_U87_Human1.33135881
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32861272
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32472625
74HTT_18923047_ChIP-ChIP_STHdh_Human1.32452213
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31695107
76* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30823283
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30448235
78CDX2_22108803_ChIP-Seq_LS180_Human1.29796009
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28659207
80TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27613356
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26789038
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.26458899
83* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25519975
84* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24935834
85KDM5A_27292631_Chip-Seq_BREAST_Human1.24734832
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23627356
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23464786
88ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23439665
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22011690
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21588806
91* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21228148
92* NFE2_27457419_Chip-Seq_LIVER_Mouse1.20546233
93* STAT3_18555785_Chip-Seq_ESCs_Mouse1.18351124
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18337056
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17354520
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17354520
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16523472
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16309558
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.15675365
100NFYA_21822215_ChIP-Seq_K562_Human1.15626831
101AR_21572438_ChIP-Seq_LNCaP_Human1.14748819
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14482337
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.14336563
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.13537245
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.13186111
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13117328
107* CTCF_18555785_Chip-Seq_ESCs_Mouse1.11713078
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11108280
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10395899
110* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10076086
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.09722633
112* KLF4_18555785_Chip-Seq_ESCs_Mouse1.09545748
113TP53_16413492_ChIP-PET_HCT116_Human1.08875254
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08075431
115ETV1_20927104_ChIP-Seq_GIST48_Human1.07944208
116* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07684819
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.07666653
118* OCT4_18555785_Chip-Seq_ESCs_Mouse1.07641991
119BCAT_22108803_ChIP-Seq_LS180_Human1.07138331
120SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06722917
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.06426096
122CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05766178
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.05756672
124KDM2B_26808549_Chip-Seq_REH_Human1.05522712
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05467987
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05139846
127* CREB1_26743006_Chip-Seq_LNCaP_Human1.03386833
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03063221
129RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03048556
130VDR_22108803_ChIP-Seq_LS180_Human1.01753711
131MYC_22102868_ChIP-Seq_BL_Human1.01501152
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00356204
133* SOX2_18555785_Chip-Seq_ESCs_Mouse1.00267880
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99905024
135KLF5_25053715_ChIP-Seq_YYC3_Human0.99883521
136* CMYC_18555785_Chip-Seq_ESCs_Mouse0.99671418
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.99529801
138* NMYC_18555785_Chip-Seq_ESCs_Mouse0.99488874
139LXR_22292898_ChIP-Seq_THP-1_Human0.98979111
140* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98705323
141* ZFX_18555785_Chip-Seq_ESCs_Mouse0.98677333
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98547467
143KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98062536
144ERG_20517297_ChIP-Seq_VCAP_Human0.97512157
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97477933
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97418247
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97356573
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.96948019
149SMAD4_21799915_ChIP-Seq_A2780_Human0.96522332
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96365888
151KDM2B_26808549_Chip-Seq_DND41_Human0.96358197
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.96031332
153* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95884175
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.95743076
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94949875
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94109719
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93160824
158GBX2_23144817_ChIP-Seq_PC3_Human0.93027128
159SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92398264
160FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92345886
161SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91995614
162EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91621198
163CHD1_26751641_Chip-Seq_LNCaP_Human0.91586279
164GF1B_26923725_Chip-Seq_HPCs_Mouse0.91125376
165GATA1_22025678_ChIP-Seq_K562_Human0.91019470
166ISL1_27105846_Chip-Seq_CPCs_Mouse0.90746764
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90694003
168TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89821532
169TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89807728
170KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87439721
171KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87439721
172KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87439721
173SOX2_20726797_ChIP-Seq_SW620_Human0.84303476
174KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83521151
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81846359
176ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81832746
177VDR_21846776_ChIP-Seq_THP-1_Human0.81200462
178STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79694636
179KDM2B_26808549_Chip-Seq_K562_Human0.78822482
180TFEB_21752829_ChIP-Seq_HELA_Human0.78535653
181ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78122393
182PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77573859
183KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77316652
184ER_23166858_ChIP-Seq_MCF-7_Human0.76822557
185DCP1A_22483619_ChIP-Seq_HELA_Human0.75907010
186BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75521272
187SMC4_20622854_ChIP-Seq_HELA_Human0.73940443
188SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.72638301
189TP63_19390658_ChIP-ChIP_HaCaT_Human0.70919676
190NOTCH1_21737748_ChIP-Seq_TLL_Human0.70839696
191WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70043509
192TRIM28_21343339_ChIP-Seq_HEK293_Human0.69620812
193RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69258010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004185_abnormal_adipocyte_glucose7.68178923
2MP0003718_maternal_effect7.01024249
3MP0002796_impaired_skin_barrier6.36745973
4MP0005451_abnormal_body_composition5.34769247
5MP0002102_abnormal_ear_morphology4.77578861
6MP0003941_abnormal_skin_development4.66754741
7MP0003646_muscle_fatigue4.57432415
8MP0003693_abnormal_embryo_hatching4.10370552
9MP0008877_abnormal_DNA_methylation3.83722954
10MP0005501_abnormal_skin_physiology3.54464968
11MP0010094_abnormal_chromosome_stability3.41650959
12MP0005666_abnormal_adipose_tissue3.14946181
13MP0005395_other_phenotype3.09999224
14MP0004381_abnormal_hair_follicle3.04369717
15MP0001119_abnormal_female_reproductive2.96760092
16MP0003699_abnormal_female_reproductive2.86469411
17MP0004957_abnormal_blastocyst_morpholog2.85859066
18MP0003111_abnormal_nucleus_morphology2.70830069
19MP0003191_abnormal_cellular_cholesterol2.69992218
20MP0003077_abnormal_cell_cycle2.67649414
21MP0002751_abnormal_autonomic_nervous2.67373085
22MP0000579_abnormal_nail_morphology2.67134178
23MP0002098_abnormal_vibrissa_morphology2.54639217
24MP0002653_abnormal_ependyma_morphology2.51263370
25MP0003787_abnormal_imprinting2.44450425
26MP0001929_abnormal_gametogenesis2.37798714
27MP0000653_abnormal_sex_gland2.26950790
28MP0003315_abnormal_perineum_morphology2.20584407
29MP0005408_hypopigmentation2.20407725
30MP0001216_abnormal_epidermal_layer2.07353545
31MP0004782_abnormal_surfactant_physiolog2.06458296
32MP0002249_abnormal_larynx_morphology2.00663693
33MP0000377_abnormal_hair_follicle1.92844301
34MP0009840_abnormal_foam_cell1.90450940
35MP0005375_adipose_tissue_phenotype1.88731821
36MP0002210_abnormal_sex_determination1.86839686
37MP0005187_abnormal_penis_morphology1.84863766
38MP0008932_abnormal_embryonic_tissue1.78115682
39MP0003937_abnormal_limbs/digits/tail_de1.77826499
40MP0005076_abnormal_cell_differentiation1.75181003
41MP0002139_abnormal_hepatobiliary_system1.74941459
42MP0005275_abnormal_skin_tensile1.72358374
43MP0009764_decreased_sensitivity_to1.66272717
44MP0010771_integument_phenotype1.65552006
45MP0000462_abnormal_digestive_system1.64194417
46MP0004233_abnormal_muscle_weight1.63751416
47MP0000467_abnormal_esophagus_morphology1.63254825
48MP0002060_abnormal_skin_morphology1.62670400
49MP0002161_abnormal_fertility/fecundity1.57925160
50MP0000627_abnormal_mammary_gland1.56976198
51MP0001905_abnormal_dopamine_level1.56182793
52MP0004947_skin_inflammation1.50251529
53MP0005646_abnormal_pituitary_gland1.48770295
54MP0000537_abnormal_urethra_morphology1.47460075
55MP0005083_abnormal_biliary_tract1.47435604
56MP0010368_abnormal_lymphatic_system1.45974597
57MP0003705_abnormal_hypodermis_morpholog1.43335218
58MP0002009_preneoplasia1.42907786
59MP0003121_genomic_imprinting1.41302382
60MP0010386_abnormal_urinary_bladder1.38429628
61MP0006292_abnormal_olfactory_placode1.37807693
62MP0001145_abnormal_male_reproductive1.29200368
63MP0010234_abnormal_vibrissa_follicle1.25612289
64MP0009931_abnormal_skin_appearance1.24485259
65MP0003221_abnormal_cardiomyocyte_apopto1.19893747
66MP0004145_abnormal_muscle_electrophysio1.18595334
67MP0008260_abnormal_autophagy1.17474975
68MP0005248_abnormal_Harderian_gland1.16693817
69MP0003566_abnormal_cell_adhesion1.14128111
70MP0001727_abnormal_embryo_implantation1.13073685
71MP0005075_abnormal_melanosome_morpholog1.13068172
72MP0000350_abnormal_cell_proliferation1.11574923
73MP0006072_abnormal_retinal_apoptosis1.11165256
74MP0002148_abnormal_hypersensitivity_rea1.11112226
75MP0002085_abnormal_embryonic_tissue1.07195735
76MP0002736_abnormal_nociception_after1.05940099
77MP0002295_abnormal_pulmonary_circulatio1.05309921
78MP0009384_cardiac_valve_regurgitation1.05257725
79MP0000639_abnormal_adrenal_gland1.01416460
80MP0002877_abnormal_melanocyte_morpholog1.00931392
81MP0005360_urolithiasis1.00040059
82MP0003453_abnormal_keratinocyte_physiol0.99860115
83MP0002254_reproductive_system_inflammat0.97327163
84MP0000490_abnormal_crypts_of0.97037562
85MP0001881_abnormal_mammary_gland0.92862420
86MP0008004_abnormal_stomach_pH0.92844600
87MP0002019_abnormal_tumor_incidence0.92389212
88MP0002160_abnormal_reproductive_system0.91301786
89MP0001485_abnormal_pinna_reflex0.90221595
90MP0005595_abnormal_vascular_smooth0.89653779
91MP0001919_abnormal_reproductive_system0.89132447
92MP0003936_abnormal_reproductive_system0.88907636
93MP0003123_paternal_imprinting0.88854657
94MP0000566_synostosis0.88712931
95MP0003950_abnormal_plasma_membrane0.87922008
96MP0001529_abnormal_vocalization0.87045712
97MP0002177_abnormal_outer_ear0.85934132
98MP0003890_abnormal_embryonic-extraembry0.84482649
99MP0000613_abnormal_salivary_gland0.83439486
100MP0002166_altered_tumor_susceptibility0.82766646
101MP0008058_abnormal_DNA_repair0.81874364
102MP0000647_abnormal_sebaceous_gland0.80737444
103MP0004264_abnormal_extraembryonic_tissu0.80633550
104MP0005448_abnormal_energy_balance0.79917803
105MP0000367_abnormal_coat/_hair0.78843639
106MP0005389_reproductive_system_phenotype0.78298987
107MP0001697_abnormal_embryo_size0.77601667
108MP0001915_intracranial_hemorrhage0.77594842
109MP0010352_gastrointestinal_tract_polyps0.77250462
110MP0002282_abnormal_trachea_morphology0.76635498
111MP0005334_abnormal_fat_pad0.76424517
112MP0002089_abnormal_postnatal_growth/wei0.76118032
113MP0010678_abnormal_skin_adnexa0.75868732
114MP0001730_embryonic_growth_arrest0.75386853
115MP0003698_abnormal_male_reproductive0.75237972
116MP0001243_abnormal_dermal_layer0.73953163
117MP0003638_abnormal_response/metabolism_0.73247376
118MP0002006_tumorigenesis0.73018848
119MP0005058_abnormal_lysosome_morphology0.72867479
120MP0009672_abnormal_birth_weight0.72511936
121MP0001191_abnormal_skin_condition0.72223839
122MP0002084_abnormal_developmental_patter0.71071183
123MP0009780_abnormal_chondrocyte_physiolo0.69336350
124MP0005310_abnormal_salivary_gland0.68537670
125MP0000762_abnormal_tongue_morphology0.67585274
126MP0000427_abnormal_hair_cycle0.66907925
127MP0001672_abnormal_embryogenesis/_devel0.64986513
128MP0005380_embryogenesis_phenotype0.64986513
129MP0003763_abnormal_thymus_physiology0.64823282
130MP0003942_abnormal_urinary_system0.64308570
131MP0003755_abnormal_palate_morphology0.63329600
132MP0001790_abnormal_immune_system0.63065109
133MP0005387_immune_system_phenotype0.63065109
134MP0002909_abnormal_adrenal_gland0.62779946
135MP0008875_abnormal_xenobiotic_pharmacok0.62556470
136MP0004510_myositis0.61172071
137MP0009250_abnormal_appendicular_skeleto0.60556669
138MP0005381_digestive/alimentary_phenotyp0.60236681
139MP0009697_abnormal_copulation0.59633015
140MP0002138_abnormal_hepatobiliary_system0.59479040
141MP0001346_abnormal_lacrimal_gland0.56928404
142MP0001873_stomach_inflammation0.56433633
143MP0000750_abnormal_muscle_regeneration0.56367426
144MP0000678_abnormal_parathyroid_gland0.56083659
145MP0004859_abnormal_synaptic_plasticity0.55164343
146MP0002116_abnormal_craniofacial_bone0.54086613
147MP0000470_abnormal_stomach_morphology0.53826886
148MP0005409_darkened_coat_color0.53606268
149MP0000465_gastrointestinal_hemorrhage0.53572580
150MP0000383_abnormal_hair_follicle0.53191190
151MP0005621_abnormal_cell_physiology0.53119138
152MP0000858_altered_metastatic_potential0.53099104
153MP0002932_abnormal_joint_morphology0.52675750
154MP0005023_abnormal_wound_healing0.52445570
155MP0001340_abnormal_eyelid_morphology0.51117580
156MP0006138_congestive_heart_failure0.50505278
157MP0002837_dystrophic_cardiac_calcinosis0.49514089
158MP0004270_analgesia0.49068412
159MP0001968_abnormal_touch/_nociception0.48744661
160MP0004484_altered_response_of0.48722553
161MP0005257_abnormal_intraocular_pressure0.48607784
162MP0010307_abnormal_tumor_latency0.47582584
163MP0000026_abnormal_inner_ear0.47239075
164MP0001944_abnormal_pancreas_morphology0.46684098
165MP0000538_abnormal_urinary_bladder0.45271112
166MP0000432_abnormal_head_morphology0.45238424
167MP0003183_abnormal_peptide_metabolism0.42570245
168MP0010155_abnormal_intestine_physiology0.42366947
169MP0003943_abnormal_hepatobiliary_system0.42073633
170MP0009703_decreased_birth_body0.41397080
171MP0001664_abnormal_digestion0.40393875
172MP0009785_altered_susceptibility_to0.40053081
173MP0001666_abnormal_nutrient_absorption0.38678171
174MP0003948_abnormal_gas_homeostasis0.37825822
175MP0004808_abnormal_hematopoietic_stem0.37577122
176MP0001177_atelectasis0.37075091
177MP0008057_abnormal_DNA_replication0.36517876
178MP0008961_abnormal_basal_metabolism0.36242259

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)6.19990498
2Congenital ichthyosiform erythroderma (HP:0007431)6.15284995
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.48511207
4Cortical dysplasia (HP:0002539)5.38584145
5Premature ovarian failure (HP:0008209)4.85801690
6Parakeratosis (HP:0001036)4.84628789
7Septate vagina (HP:0001153)4.82302567
8Increased IgE level (HP:0003212)4.73230457
9Palmoplantar hyperkeratosis (HP:0000972)4.63403212
10Chromsome breakage (HP:0040012)4.53305400
11Infertility (HP:0000789)4.33228300
12Palmar hyperkeratosis (HP:0010765)4.31601592
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.28478987
14Distal lower limb muscle weakness (HP:0009053)3.96683467
15Papillary thyroid carcinoma (HP:0002895)3.87726130
16Erythema (HP:0010783)3.86526408
17Plantar hyperkeratosis (HP:0007556)3.81291049
18Erythroderma (HP:0001019)3.76712084
19Onycholysis (HP:0001806)3.76260765
20Breast hypoplasia (HP:0003187)3.69901051
21Shawl scrotum (HP:0000049)3.68892119
22Flat capital femoral epiphysis (HP:0003370)3.68054421
23Pseudobulbar signs (HP:0002200)3.66812321
24Axonal loss (HP:0003447)3.60663772
25Micronodular cirrhosis (HP:0001413)3.44334166
26Ectropion (HP:0000656)3.42683650
27Right ventricular cardiomyopathy (HP:0011663)3.36571752
28Spondylolisthesis (HP:0003302)3.35797191
29Abnormality of placental membranes (HP:0011409)3.33995839
30Amniotic constriction ring (HP:0009775)3.33995839
31Deep philtrum (HP:0002002)3.32815431
32Adrenal hypoplasia (HP:0000835)3.32801300
33Pulmonary fibrosis (HP:0002206)3.32077410
34Hypergonadotropic hypogonadism (HP:0000815)3.30170437
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30048363
36J-shaped sella turcica (HP:0002680)3.29629058
37Rhabdomyosarcoma (HP:0002859)3.26906946
38Hypotrichosis (HP:0001006)3.24397698
39Abnormality of the labia minora (HP:0012880)3.22719116
40Thick nail (HP:0001805)3.22047264
41Corneal erosion (HP:0200020)3.18424651
42Insulin-resistant diabetes mellitus (HP:0000831)3.16508462
43Birth length less than 3rd percentile (HP:0003561)3.16184215
44Secondary amenorrhea (HP:0000869)3.15441735
45Arterial tortuosity (HP:0005116)3.12537239
46Gangrene (HP:0100758)3.07131158
47Abnormality of the fovea (HP:0000493)3.00927862
48Microglossia (HP:0000171)2.97620061
49Hypoplasia of the fovea (HP:0007750)2.95470677
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.95470677
51Asymmetry of the thorax (HP:0001555)2.95066176
52Ventricular fibrillation (HP:0001663)2.94434798
53Curly hair (HP:0002212)2.93531905
54Germ cell neoplasia (HP:0100728)2.92063592
55Supernumerary spleens (HP:0009799)2.90762641
56Amelogenesis imperfecta (HP:0000705)2.86562103
57Cholecystitis (HP:0001082)2.86102160
58Abnormal gallbladder physiology (HP:0012438)2.86102160
59Patellar aplasia (HP:0006443)2.86070090
60Deep venous thrombosis (HP:0002625)2.85060358
61Oral leukoplakia (HP:0002745)2.77623938
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76276274
63Abnormality of chromosome stability (HP:0003220)2.73596007
64Vascular tortuosity (HP:0004948)2.68148618
65Sloping forehead (HP:0000340)2.66611492
66Abnormality of the fingertips (HP:0001211)2.65863521
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.64137590
68Palmoplantar keratoderma (HP:0000982)2.63300128
69Nail dystrophy (HP:0008404)2.63276796
70Abnormality of chromosome segregation (HP:0002916)2.63115489
71Hypohidrosis (HP:0000966)2.62002294
72Chorioretinal atrophy (HP:0000533)2.60837290
73Exostoses (HP:0100777)2.59652228
74Akinesia (HP:0002304)2.59463790
75Insidious onset (HP:0003587)2.58879218
76Termporal pattern (HP:0011008)2.58879218
77Aplasia/Hypoplasia of the patella (HP:0006498)2.55887569
78Hyperglycemia (HP:0003074)2.53333433
79Abnormality of the preputium (HP:0100587)2.50189664
80Breast carcinoma (HP:0003002)2.49025662
81Hyperparathyroidism (HP:0000843)2.48003658
82Absent radius (HP:0003974)2.46981456
83Absent forearm bone (HP:0003953)2.37745874
84Aplasia involving forearm bones (HP:0009822)2.37745874
85Oligodactyly (hands) (HP:0001180)2.37383922
86Abnormality of abdominal situs (HP:0011620)2.36947222
87Abdominal situs inversus (HP:0003363)2.36947222
88Natal tooth (HP:0000695)2.34881916
89Advanced eruption of teeth (HP:0006288)2.34192312
90Alopecia of scalp (HP:0002293)2.30134307
91Ridged nail (HP:0001807)2.29209178
92Abnormality of the gastric mucosa (HP:0004295)2.26745703
93Woolly hair (HP:0002224)2.26677369
94Follicular hyperkeratosis (HP:0007502)2.25900357
95Aplasia/Hypoplasia of the breasts (HP:0010311)2.25781267
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24754083
97Lip pit (HP:0100267)2.21018616
98Fragile nails (HP:0001808)2.19815967
99Abdominal distention (HP:0003270)2.19208676
100Pruritus (HP:0000989)2.18658139
101Nonprogressive disorder (HP:0003680)2.18303573
102Severe Myopia (HP:0011003)2.18215609
103Loss of speech (HP:0002371)2.17371380
104Abnormality of the proximal phalanges of the hand (HP:0009834)2.16801511
105Neoplasm of striated muscle (HP:0009728)2.15792274
106Sandal gap (HP:0001852)2.15677725
107Breast aplasia (HP:0100783)2.14904112
108Hypoparathyroidism (HP:0000829)2.14850100
109Facial hemangioma (HP:0000329)2.14572344
110Primary amenorrhea (HP:0000786)2.13795905
111Medulloblastoma (HP:0002885)2.13414195
112Aplasia involving bones of the extremities (HP:0009825)2.13179563
113Aplasia involving bones of the upper limbs (HP:0009823)2.13179563
114Aplasia of the phalanges of the hand (HP:0009802)2.13179563
115Esophageal varix (HP:0002040)2.11530376
116Interstitial pulmonary disease (HP:0006530)2.10512702
117Oligodactyly (HP:0012165)2.10430123
118Abnormality of the salivary glands (HP:0010286)2.08528770
119Pterygium (HP:0001059)2.06928166
120Chronic bronchitis (HP:0004469)2.06741274
121Flat acetabular roof (HP:0003180)2.05148622
122Aplasia/Hypoplasia of the uvula (HP:0010293)2.03982344
123Combined immunodeficiency (HP:0005387)2.03852941
124Small intestinal stenosis (HP:0012848)2.02455706
125Duodenal stenosis (HP:0100867)2.02455706
126Atelectasis (HP:0100750)2.01926437
127Hyporeflexia of lower limbs (HP:0002600)2.01882298
128Retrobulbar optic neuritis (HP:0100654)2.01369001
129Optic neuritis (HP:0100653)2.01369001
130Abnormality of the frontal sinuses (HP:0002687)2.00058833
131Abnormality of nail color (HP:0100643)12.4864120
132Male infertility (HP:0003251)11.2237557
133Hypoplastic iliac wings (HP:0002866)1.99852687
134Dehydration (HP:0001944)1.99695683
135Wrist flexion contracture (HP:0001239)1.98951071
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.97997923
137Absent frontal sinuses (HP:0002688)1.97014354
138Sparse eyelashes (HP:0000653)1.94794618
139Acute myeloid leukemia (HP:0004808)1.93895228
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92682281
141Abnormal auditory evoked potentials (HP:0006958)1.92196588
142Popliteal pterygium (HP:0009756)1.90815987
143Abnormal lung lobation (HP:0002101)1.90777432
144Aplastic anemia (HP:0001915)1.89747267
145Fetal akinesia sequence (HP:0001989)1.88627145
146Sparse lateral eyebrow (HP:0005338)1.88346514
147Thyroid carcinoma (HP:0002890)1.87773143
148Capillary hemangiomas (HP:0005306)1.86899302
149Thin bony cortex (HP:0002753)1.85567619
150Facial shape deformation (HP:0011334)1.85094889
151Potter facies (HP:0002009)1.85094889
152Fibular aplasia (HP:0002990)1.84990521
153Deformed sella turcica (HP:0002681)1.83666668
154Arachnodactyly (HP:0001166)1.83275641
155Posterior embryotoxon (HP:0000627)1.82710157
156Bicornuate uterus (HP:0000813)1.81390635
157Aplasia cutis congenita (HP:0001057)1.80796034
158Meckel diverticulum (HP:0002245)1.80224058
159Short thumb (HP:0009778)1.79662116
160Aplasia/Hypoplasia of the macula (HP:0008059)1.77988012
161Long nose (HP:0003189)1.77172739
162Anterior segment dysgenesis (HP:0007700)1.77164898
163Unilateral renal agenesis (HP:0000122)1.77092805
164Acute lymphatic leukemia (HP:0006721)1.76864488
165Malnutrition (HP:0004395)1.73419361
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72903321
167Seborrheic dermatitis (HP:0001051)1.72780303
168Autoamputation (HP:0001218)1.72558417
169Abnormality of the epiphysis of the femoral head (HP:0010574)1.72434907
170Bone pain (HP:0002653)1.72295098
171Abnormal blistering of the skin (HP:0008066)1.72280341
172Abnormality of the line of Schwalbe (HP:0008048)1.69849424
173Testicular neoplasm (HP:0010788)1.69271069
174Diminished movement (HP:0002374)1.67471261
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66975337
176Short nail (HP:0001799)1.63289247
177Conjunctival hamartoma (HP:0100780)1.63095980
178Abnormality of secondary sexual hair (HP:0009888)1.63029826
179Abnormality of the axillary hair (HP:0100134)1.63029826
180Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62793864
181Increased neuronal autofluorescent lipopigment (HP:0002074)1.61944375
182Hyperhidrosis (HP:0000975)1.61702138
183Lack of skin elasticity (HP:0100679)1.60801707
184Patellar dislocation (HP:0002999)1.59653863
185Polygenic inheritance (HP:0010982)1.58847683
186Anonychia (HP:0001798)1.58521171
187Aplasia of the musculature (HP:0100854)1.57118391
188Long toe (HP:0010511)1.55384603
189Villous atrophy (HP:0011473)1.53541289
190Abnormality of small intestinal villus morphology (HP:0011472)1.53541289
191Reticulocytosis (HP:0001923)1.53316303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.92225812
2MAP3K64.96376251
3SIK14.89483026
4TAOK34.29496979
5TTK4.03656797
6TRIB33.77760241
7ERBB43.38193080
8MOS3.35664190
9LATS13.17848043
10IRAK33.14358089
11BRAF3.11537013
12PLK42.99054806
13MAP3K92.98134821
14MUSK2.96415356
15KSR22.90368786
16LATS22.82760276
17SCYL22.77474573
18ARAF2.62991948
19MAP3K132.42723390
20TESK12.41390021
21BMPR22.38699373
22GRK62.25563670
23NEK62.18857326
24NME22.13608361
25RAF12.04222401
26STK102.02399960
27EEF2K1.97590300
28FGFR41.97004273
29PKN21.95670230
30NUAK11.88183207
31STK38L1.87563489
32MAP2K21.85934460
33SIK31.85701041
34CHEK21.78403154
35CDC71.77904664
36SMG11.73747680
37TSSK61.71739902
38MELK1.70057232
39KSR11.55636668
40PIM21.45725655
41DYRK31.45103503
42MAP3K41.43701429
43NEK11.41108384
44PIK3CA1.37560563
45NEK21.37526101
46CSNK1G11.35403691
47NEK91.35292832
48PLK11.34924767
49PRKD31.31224444
50CDK91.29704331
51STK31.27290136
52CSNK1G31.25524819
53PAK61.25035526
54LMTK21.24031523
55TAOK11.21993705
56EIF2AK21.19987345
57CDK81.19783599
58PAK41.18820304
59IKBKB1.18544836
60MAP3K81.18102995
61IKBKE1.17598867
62DMPK1.13452521
63TESK21.13190274
64SRPK11.12636496
65RIPK11.12243174
66MAP3K141.11024781
67MAP2K71.08233844
68MAP3K121.07395448
69MAP3K21.06732030
70TAOK21.05321211
71CSNK1A1L1.04957755
72CSNK1G21.00661772
73ICK0.99392429
74MTOR0.98859119
75DYRK20.96741431
76TBK10.95805441
77MAPK130.94871383
78MAP3K30.92795869
79NLK0.92606498
80CDK70.91422720
81BUB10.91053510
82PRKAA20.88671961
83RPS6KB10.88322371
84AURKB0.86319623
85CSF1R0.85874320
86MAPKAPK30.85255615
87DYRK1B0.81204832
88VRK10.80809211
89AURKA0.77376484
90VRK20.76641660
91MAPKAPK50.75262861
92CAMK2G0.74738649
93ABL20.72348959
94PDGFRA0.71668518
95MAPK40.69307705
96FER0.64474090
97PDGFRB0.64333609
98MAPKAPK20.62119220
99PRKAA10.61307112
100MAP2K40.60238562
101PRKD20.59487853
102EIF2AK30.59487250
103CAMK2B0.59357545
104CDK60.58123006
105PRKCI0.57321830
106YES10.55423873
107CDK120.55159046
108CAMK2D0.53876597
109RET0.52967328
110WEE10.51962285
111PLK30.51413272
112TYRO30.49744127
113CHEK10.48289199
114TAF10.47992331
115ATM0.44857874
116PTK20.43215356
117NTRK20.41715786
118RPS6KA20.40924138
119PTK60.40298514
120RPS6KA10.39934534
121ILK0.37127565
122STK160.36510745
123CAMK2A0.35080316
124BRD40.34167108
125TRIM280.33440339
126HIPK20.33020434
127STK240.32958709
128MAPK80.32392573
129RPS6KL10.31632249
130RPS6KC10.31632249
131ABL10.30675833
132BMPR1B0.30660939
133MAP3K10.30058767
134RPS6KA40.28970455
135MAP3K50.27879669
136ERN10.27863734
137JAK10.27861161
138PDPK10.27760793
139LIMK10.27365914
140EIF2AK10.26112682
141IRAK10.25779916
142IRAK40.25239962
143AKT10.24097932
144STK380.24091982
145MAPK90.23811758
146CDK10.22419576
147JAK20.22331904
148TRPM70.22118548
149CLK10.21947287
150CSNK1A10.21128681
151CSNK1D0.20139241
152RPS6KB20.20123279
153PBK0.19218026
154SGK20.18705501
155MAPK30.18588375
156RPS6KA60.18173286
157PRKG10.17759053
158CDK20.17154634
159MAPK110.16007530
160CHUK0.15528231
161PIM10.15014685
162CDK40.14991945
163SGK2230.14326125
164SGK4940.14326125
165PAK30.14242109
166EPHA40.13793405
167STK110.13472827
168MAP2K10.12803996
169PASK0.12803944
170IRAK20.11511072
171MARK20.11275812
172KIT0.10995412
173ERBB20.10900407
174ROCK10.09291988
175CSNK1E0.08957475

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.41284109
2Cell cycle_Homo sapiens_hsa041104.03001827
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.78268441
4Basal transcription factors_Homo sapiens_hsa030223.70576732
5RNA degradation_Homo sapiens_hsa030183.64641360
6Homologous recombination_Homo sapiens_hsa034402.84509822
7Base excision repair_Homo sapiens_hsa034102.82084978
8Sphingolipid metabolism_Homo sapiens_hsa006002.76180821
9Linoleic acid metabolism_Homo sapiens_hsa005912.70672213
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66218779
11Ether lipid metabolism_Homo sapiens_hsa005652.64699558
12Vitamin B6 metabolism_Homo sapiens_hsa007502.57582645
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37459705
14Fanconi anemia pathway_Homo sapiens_hsa034602.37448516
15Oocyte meiosis_Homo sapiens_hsa041142.27105681
16Pancreatic cancer_Homo sapiens_hsa052122.22097820
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.14849567
18Hepatitis C_Homo sapiens_hsa051602.02831421
19p53 signaling pathway_Homo sapiens_hsa041152.01968613
20Dorso-ventral axis formation_Homo sapiens_hsa043201.98260255
21Acute myeloid leukemia_Homo sapiens_hsa052211.97014900
22Circadian rhythm_Homo sapiens_hsa047101.93355374
23Non-homologous end-joining_Homo sapiens_hsa034501.85648092
24GnRH signaling pathway_Homo sapiens_hsa049121.81493561
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80180429
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74805973
27ErbB signaling pathway_Homo sapiens_hsa040121.73328925
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72749562
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70721053
30Nucleotide excision repair_Homo sapiens_hsa034201.66967435
31Mismatch repair_Homo sapiens_hsa034301.61923903
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60892083
33Legionellosis_Homo sapiens_hsa051341.56889450
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.56830795
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.56385669
36TGF-beta signaling pathway_Homo sapiens_hsa043501.51700414
37Insulin resistance_Homo sapiens_hsa049311.46088753
38Prostate cancer_Homo sapiens_hsa052151.45729679
39MicroRNAs in cancer_Homo sapiens_hsa052061.43316634
40DNA replication_Homo sapiens_hsa030301.40994302
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39846724
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.39447981
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.38624795
44Colorectal cancer_Homo sapiens_hsa052101.35091218
45Inositol phosphate metabolism_Homo sapiens_hsa005621.31379212
46RNA transport_Homo sapiens_hsa030131.27561462
47Influenza A_Homo sapiens_hsa051641.25666096
48Insulin signaling pathway_Homo sapiens_hsa049101.21824905
49Viral carcinogenesis_Homo sapiens_hsa052031.19891538
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18800513
51B cell receptor signaling pathway_Homo sapiens_hsa046621.17851119
52RNA polymerase_Homo sapiens_hsa030201.15740593
53Vibrio cholerae infection_Homo sapiens_hsa051101.15617608
54Systemic lupus erythematosus_Homo sapiens_hsa053221.14983293
55One carbon pool by folate_Homo sapiens_hsa006701.14112994
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.13322603
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12962534
58Fructose and mannose metabolism_Homo sapiens_hsa000511.12373864
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10029665
60Lysosome_Homo sapiens_hsa041421.09717826
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08787551
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08169527
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08119428
64Choline metabolism in cancer_Homo sapiens_hsa052311.05054459
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04712423
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04459509
67AMPK signaling pathway_Homo sapiens_hsa041521.03489751
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02341162
69Alcoholism_Homo sapiens_hsa050341.01439441
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98442448
71Endocytosis_Homo sapiens_hsa041440.96817013
72Prolactin signaling pathway_Homo sapiens_hsa049170.96635064
73Glioma_Homo sapiens_hsa052140.95166895
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94776943
75Prion diseases_Homo sapiens_hsa050200.94082460
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.93946230
77VEGF signaling pathway_Homo sapiens_hsa043700.93755651
78Measles_Homo sapiens_hsa051620.93376437
79Shigellosis_Homo sapiens_hsa051310.93367027
80Salmonella infection_Homo sapiens_hsa051320.92168683
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91444684
82HIF-1 signaling pathway_Homo sapiens_hsa040660.90096420
83Tight junction_Homo sapiens_hsa045300.89543396
84Long-term depression_Homo sapiens_hsa047300.87397291
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.85548134
86Proteoglycans in cancer_Homo sapiens_hsa052050.84379003
87Melanoma_Homo sapiens_hsa052180.82832949
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82154449
89Herpes simplex infection_Homo sapiens_hsa051680.77740898
90Type II diabetes mellitus_Homo sapiens_hsa049300.76635972
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.76306623
92Apoptosis_Homo sapiens_hsa042100.75976285
93Adherens junction_Homo sapiens_hsa045200.75332152
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75030638
95Ras signaling pathway_Homo sapiens_hsa040140.73281667
96Hippo signaling pathway_Homo sapiens_hsa043900.70438917
97Other glycan degradation_Homo sapiens_hsa005110.68434996
98Amoebiasis_Homo sapiens_hsa051460.66595634
99T cell receptor signaling pathway_Homo sapiens_hsa046600.65991552
100Arachidonic acid metabolism_Homo sapiens_hsa005900.65854516
101Fatty acid elongation_Homo sapiens_hsa000620.65341202
102Pyrimidine metabolism_Homo sapiens_hsa002400.63849839
103Sulfur relay system_Homo sapiens_hsa041220.63706185
104Serotonergic synapse_Homo sapiens_hsa047260.62927459
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62393400
106Tuberculosis_Homo sapiens_hsa051520.61698241
107Osteoclast differentiation_Homo sapiens_hsa043800.60649030
108Glutamatergic synapse_Homo sapiens_hsa047240.59239750
109Epstein-Barr virus infection_Homo sapiens_hsa051690.59031167
110Bladder cancer_Homo sapiens_hsa052190.58042214
111Pentose phosphate pathway_Homo sapiens_hsa000300.54655107
112Toxoplasmosis_Homo sapiens_hsa051450.54452215
113Histidine metabolism_Homo sapiens_hsa003400.53751670
114* Jak-STAT signaling pathway_Homo sapiens_hsa046300.53524097
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53400039
116Small cell lung cancer_Homo sapiens_hsa052220.53099015
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52636029
118Renal cell carcinoma_Homo sapiens_hsa052110.51106733
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51104556
120beta-Alanine metabolism_Homo sapiens_hsa004100.50889065
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.48941365
122Rheumatoid arthritis_Homo sapiens_hsa053230.47722377
123Folate biosynthesis_Homo sapiens_hsa007900.47436779
124FoxO signaling pathway_Homo sapiens_hsa040680.47315808
125Spliceosome_Homo sapiens_hsa030400.45778903
126Arginine and proline metabolism_Homo sapiens_hsa003300.45197659
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.44329209
128Protein export_Homo sapiens_hsa030600.42263908
129ABC transporters_Homo sapiens_hsa020100.42256293
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41818101
131Thyroid cancer_Homo sapiens_hsa052160.41752627
132MAPK signaling pathway_Homo sapiens_hsa040100.41606197
133mTOR signaling pathway_Homo sapiens_hsa041500.41456596
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40435137
135Estrogen signaling pathway_Homo sapiens_hsa049150.40133860
136Endometrial cancer_Homo sapiens_hsa052130.39254565
137HTLV-I infection_Homo sapiens_hsa051660.39216229
138Non-small cell lung cancer_Homo sapiens_hsa052230.38434587
139Purine metabolism_Homo sapiens_hsa002300.38029782
140Lysine degradation_Homo sapiens_hsa003100.35368773
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33689241
142Butanoate metabolism_Homo sapiens_hsa006500.33104766
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30051229
144Chronic myeloid leukemia_Homo sapiens_hsa052200.29692370
145TNF signaling pathway_Homo sapiens_hsa046680.29243054
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.28807546
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.26467189
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26130148
149Retinol metabolism_Homo sapiens_hsa008300.25833981
150Notch signaling pathway_Homo sapiens_hsa043300.25799108
151mRNA surveillance pathway_Homo sapiens_hsa030150.25729244
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24941420
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24860892
154Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24385034
155Hepatitis B_Homo sapiens_hsa051610.22973475
156cAMP signaling pathway_Homo sapiens_hsa040240.22631217
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.21701472
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21368062
159Pyruvate metabolism_Homo sapiens_hsa006200.21215650
160Pathways in cancer_Homo sapiens_hsa052000.18977841
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.18778969
162Wnt signaling pathway_Homo sapiens_hsa043100.18383903
163Oxytocin signaling pathway_Homo sapiens_hsa049210.18176724
164Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16739202
165Huntingtons disease_Homo sapiens_hsa050160.16735511
166Platelet activation_Homo sapiens_hsa046110.15484961

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