IL20RB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.96342396
2regulation of water loss via skin (GO:0033561)8.21880619
3keratinization (GO:0031424)7.83523268
4cell-substrate junction assembly (GO:0007044)6.56243598
5keratinocyte proliferation (GO:0043616)6.31919508
6hemidesmosome assembly (GO:0031581)6.31438509
7sphingoid metabolic process (GO:0046519)6.27771485
8keratinocyte differentiation (GO:0030216)6.07414596
9regulation of keratinocyte proliferation (GO:0010837)6.00562391
10establishment of tissue polarity (GO:0007164)5.87683682
11establishment of planar polarity (GO:0001736)5.87683682
12polarized epithelial cell differentiation (GO:0030859)5.66831240
13multicellular organismal water homeostasis (GO:0050891)5.59167468
14regulation of phospholipase A2 activity (GO:0032429)5.59024475
15sphingosine metabolic process (GO:0006670)5.45598301
16interferon-gamma secretion (GO:0072643)5.43441561
17gap junction assembly (GO:0016264)5.28417548
18glucosamine-containing compound catabolic process (GO:1901072)5.25111112
19intermediate filament cytoskeleton organization (GO:0045104)5.02575633
20keratinocyte development (GO:0003334)4.88940171
21intermediate filament-based process (GO:0045103)4.87274077
22detection of bacterium (GO:0016045)4.85676759
23diol metabolic process (GO:0034311)4.83455720
24regulation of chemokine secretion (GO:0090196)4.82658008
25positive regulation of epidermal cell differentiation (GO:0045606)4.71420356
26epidermal cell differentiation (GO:0009913)4.69667087
27surfactant homeostasis (GO:0043129)4.67737574
28water homeostasis (GO:0030104)4.66864051
29hair cycle (GO:0042633)4.63823449
30molting cycle (GO:0042303)4.63823449
31regulation of ruffle assembly (GO:1900027)4.54375966
32regulation of cell proliferation involved in kidney development (GO:1901722)4.53225829
33lateral sprouting from an epithelium (GO:0060601)4.50801367
34regulation of hair follicle development (GO:0051797)4.38083798
35peptide cross-linking (GO:0018149)4.36348992
36detection of other organism (GO:0098543)4.29513552
37positive regulation of interleukin-8 secretion (GO:2000484)4.20241007
38intestinal epithelial cell development (GO:0060576)4.16732189
39chemical homeostasis within a tissue (GO:0048875)4.15773273
40regulation of keratinocyte differentiation (GO:0045616)4.12771154
41bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06380784
42epidermis development (GO:0008544)4.06217853
43epithelial cell differentiation involved in prostate gland development (GO:0060742)4.05272320
44regulation of interleukin-8 secretion (GO:2000482)4.00992604
45viral transcription (GO:0019083)3.95430980
46intermediate filament organization (GO:0045109)3.94154563
47positive regulation of chemokine secretion (GO:0090197)3.93912600
48positive regulation of keratinocyte differentiation (GO:0045618)3.93049130
49cell adhesion mediated by integrin (GO:0033627)3.89224668
50regulation of epidermis development (GO:0045682)3.85252277
51negative regulation of keratinocyte proliferation (GO:0010839)3.79548562
52cyclooxygenase pathway (GO:0019371)3.64573049
53translational termination (GO:0006415)3.63477051
54positive regulation of antigen processing and presentation (GO:0002579)3.58046872
55ribosomal small subunit biogenesis (GO:0042274)3.56592050
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.55253293
57regulation of hair cycle (GO:0042634)3.49339303
58negative regulation of stress fiber assembly (GO:0051497)3.47924626
59negative regulation of epidermis development (GO:0045683)3.42141456
60cellular response to interferon-alpha (GO:0035457)3.34795163
61cardiac right ventricle morphogenesis (GO:0003215)3.32230353
62regulation of transforming growth factor beta2 production (GO:0032909)3.29059897
63G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.27343870
64epithelium development (GO:0060429)3.27088154
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25196261
66skin development (GO:0043588)3.24413099
67ventricular cardiac muscle cell action potential (GO:0086005)3.24183235
68prostanoid biosynthetic process (GO:0046457)3.23867833
69prostaglandin biosynthetic process (GO:0001516)3.23867833
70regulation of epidermal cell differentiation (GO:0045604)3.23767928
71negative regulation of kidney development (GO:0090185)3.23483967
72gland morphogenesis (GO:0022612)3.19205258
73diterpenoid biosynthetic process (GO:0016102)3.17293719
74regulation of natural killer cell differentiation (GO:0032823)3.15475479
75morphogenesis of embryonic epithelium (GO:0016331)3.15237189
76T-helper cell differentiation (GO:0042093)3.12376955
77CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.12376955
78positive regulation of vesicle fusion (GO:0031340)3.09725728
79long-chain fatty acid biosynthetic process (GO:0042759)2.98539018
80lipoxygenase pathway (GO:0019372)2.98513855
81hypotonic response (GO:0006971)2.95266646
82positive regulation of monocyte chemotaxis (GO:0090026)2.95112048
83leukotriene metabolic process (GO:0006691)2.94762700
84sympathetic nervous system development (GO:0048485)2.94125128
85regulation of antigen processing and presentation (GO:0002577)2.92951629
86mesodermal cell differentiation (GO:0048333)2.92786824
87cell junction assembly (GO:0034329)2.92122443
88interleukin-1-mediated signaling pathway (GO:0070498)2.87107945
89positive regulation of hair cycle (GO:0042635)2.86916701
90positive regulation of hair follicle development (GO:0051798)2.86916701
91cell junction organization (GO:0034330)2.86663396
92viral life cycle (GO:0019058)2.86588565
93protein localization to endosome (GO:0036010)2.85844797
94hair follicle morphogenesis (GO:0031069)2.85525412
95amino sugar catabolic process (GO:0046348)2.84327541
96endodermal cell differentiation (GO:0035987)2.83185651
97L-serine transport (GO:0015825)2.81777633
98negative regulation of interleukin-8 production (GO:0032717)2.80331626
99terpenoid biosynthetic process (GO:0016114)2.80112829
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79237919
101phospholipid scrambling (GO:0017121)2.77939356
102molting cycle process (GO:0022404)2.77339968
103hair cycle process (GO:0022405)2.77339968
104endosome organization (GO:0007032)2.76926555
105regulation of endothelial cell chemotaxis (GO:2001026)2.76648890
106positive regulation of epidermis development (GO:0045684)2.73337842
107protein targeting to ER (GO:0045047)2.72918398
108regulation of glomerular filtration (GO:0003093)2.72305269
109regulation of transforming growth factor beta1 production (GO:0032908)2.71546245
110translational elongation (GO:0006414)2.70821403
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69919748
112ribosomal small subunit assembly (GO:0000028)2.69816928
113regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.69205819
114negative regulation of cell aging (GO:0090344)2.68901057
115cotranslational protein targeting to membrane (GO:0006613)2.68653493
116linoleic acid metabolic process (GO:0043651)2.68462107
117detection of external biotic stimulus (GO:0098581)2.68427701
118mitotic G1 DNA damage checkpoint (GO:0031571)2.67808153
119alpha-beta T cell differentiation involved in immune response (GO:0002293)2.67681782
120alpha-beta T cell activation involved in immune response (GO:0002287)2.67681782
121T cell differentiation involved in immune response (GO:0002292)2.67681782
122regulation of heart rate by cardiac conduction (GO:0086091)2.67402863
123negative regulation of actin filament bundle assembly (GO:0032232)2.66991659
124eyelid development in camera-type eye (GO:0061029)2.66210686
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65866157
126phosphatidylserine acyl-chain remodeling (GO:0036150)2.65855883
127epithelial cell-cell adhesion (GO:0090136)2.65468907
128maturation of SSU-rRNA (GO:0030490)2.65008689
129cellular protein complex disassembly (GO:0043624)2.64742761
130negative regulation of cell fate specification (GO:0009996)2.64602592
131negative regulation of chondrocyte differentiation (GO:0032331)2.64488974
132prostanoid metabolic process (GO:0006692)2.63860693
133prostaglandin metabolic process (GO:0006693)2.63860693
134positive regulation of interleukin-1 beta secretion (GO:0050718)2.62215042
135ectoderm development (GO:0007398)2.61657427
136natural killer cell mediated cytotoxicity (GO:0042267)2.59321130
137natural killer cell mediated immunity (GO:0002228)2.59321130
138epithelial cell proliferation (GO:0050673)2.57839327
139regulation of metalloenzyme activity (GO:0048552)2.55497637
140regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.55399723
141skin morphogenesis (GO:0043589)2.54661908
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54098725
143plasma membrane repair (GO:0001778)2.53388380
144positive regulation of cholesterol efflux (GO:0010875)2.53012796
145positive regulation of interleukin-1 beta production (GO:0032731)2.52777710
146icosanoid biosynthetic process (GO:0046456)2.52186940
147fatty acid derivative biosynthetic process (GO:1901570)2.52186940
148atrioventricular valve morphogenesis (GO:0003181)2.51232077
149protein localization to endoplasmic reticulum (GO:0070972)2.50939366
150* negative regulation of interferon-gamma production (GO:0032689)2.50800414
151nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50601822
152fatty acid elongation (GO:0030497)2.50155203
153cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.49620763
154phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48179216
155negative regulation of cell fate commitment (GO:0010454)2.48067006
156cellular copper ion homeostasis (GO:0006878)2.47189574
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47076822
158regulation of fibroblast apoptotic process (GO:2000269)2.46417072
159glomerular visceral epithelial cell development (GO:0072015)2.46346039
160mitotic G1/S transition checkpoint (GO:0044819)2.42698577
161G1 DNA damage checkpoint (GO:0044783)2.41424564
162negative regulation of epidermal cell differentiation (GO:0045605)2.39196920
163wound healing (GO:0042060)2.36046425
164desmosome organization (GO:0002934)11.9823360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.58051407
2ZNF263_19887448_ChIP-Seq_K562_Human3.06637919
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.60858537
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58632322
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.50093953
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05135012
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.02325848
8TP63_17297297_ChIP-ChIP_HaCaT_Human14.1772380
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97342118
10RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94506600
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.81065558
12ATF3_27146783_Chip-Seq_COLON_Human1.80026115
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70737435
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69212043
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69212043
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69110536
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67032837
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.55310140
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46408331
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.44488339
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.43640337
22ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39849605
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39704391
24* CJUN_26792858_Chip-Seq_BT549_Human1.37436221
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.36558891
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36382068
27AR_21572438_ChIP-Seq_LNCaP_Human1.36215490
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34400212
29* TP63_23658742_ChIP-Seq_EP156T_Human1.33429398
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.30470429
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.30332160
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30008099
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29286148
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28957983
35SOX2_20726797_ChIP-Seq_SW620_Human1.26739546
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26079623
37TP53_18474530_ChIP-ChIP_U2OS_Human1.25319155
38* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22991234
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22692162
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18085470
41AHR_22903824_ChIP-Seq_MCF-7_Human1.16505105
42RXR_22108803_ChIP-Seq_LS180_Human1.16363385
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15817625
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14042367
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13996632
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13733079
47VDR_22108803_ChIP-Seq_LS180_Human1.12559791
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12223823
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.10386740
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.09969690
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.09468408
52KLF5_25053715_ChIP-Seq_YYC3_Human1.08731576
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.08113582
54GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07818972
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07547470
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07446006
57GATA6_25053715_ChIP-Seq_YYC3_Human1.06792928
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06747133
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.05517761
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05303823
61GATA1_22025678_ChIP-Seq_K562_Human1.05026468
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.04990737
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03649743
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03649743
65RACK7_27058665_Chip-Seq_MCF-7_Human1.01517785
66JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98757684
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97948689
68RNF2_27304074_Chip-Seq_ESCs_Mouse0.97166220
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96924609
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95841182
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94560739
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94475600
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93316655
74* TP63_22573176_ChIP-Seq_HFKS_Human0.93242053
75RUNX1_27514584_Chip-Seq_MCF-7_Human0.92666004
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.92288178
77TP53_16413492_ChIP-PET_HCT116_Human0.92201088
78BCAT_22108803_ChIP-Seq_LS180_Human0.92042230
79AR_21909140_ChIP-Seq_LNCAP_Human0.91425531
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90539793
81TCF4_22108803_ChIP-Seq_LS180_Human0.89642657
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.88512478
83* GATA2_21666600_ChIP-Seq_HMVEC_Human0.88353009
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86776989
85P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84869356
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84640455
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84453101
88CBX2_27304074_Chip-Seq_ESCs_Mouse0.82451140
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81169170
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79199877
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79181990
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.78025729
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77977614
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77507797
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77487872
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77200621
97CEBPB_22108803_ChIP-Seq_LS180_Human0.76199314
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.75742342
99EGR1_19032775_ChIP-ChIP_M12_Human0.74628532
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73973033
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73417755
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72617703
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.72520480
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71587157
105CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71033751
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70402819
107* BRD4_25478319_ChIP-Seq_HGPS_Human0.70302627
108GATA4_25053715_ChIP-Seq_YYC3_Human0.70061727
109CLOCK_20551151_ChIP-Seq_293T_Human0.69254145
110AR_25329375_ChIP-Seq_VCAP_Human0.68349844
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.68063829
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67941210
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67800572
114RNF2_27304074_Chip-Seq_NSC_Mouse0.67149273
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66361945
116HNFA_21074721_ChIP-Seq_CACO-2_Human0.66057867
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66018352
118DROSHA_22980978_ChIP-Seq_HELA_Human0.65427125
119RBPJ_21746931_ChIP-Seq_IB4_Human0.64717433
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64668370
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64364037
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.63940033
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63934075
124PHF8_20622853_ChIP-Seq_HELA_Human0.63781629
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.63699127
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.63402381
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62734369
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.62590528
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.62558458
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62271294
131TP53_22127205_ChIP-Seq_IMR90_Human0.61500466
132PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.61412095
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.60450321
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.60436207
135ELF5_23300383_ChIP-Seq_T47D_Human0.60079203
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58866548
137CHD1_26751641_Chip-Seq_LNCaP_Human0.58198384
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.57301681
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56850308
140ETV1_20927104_ChIP-Seq_GIST48_Human0.56812990
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.56510689
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.56234108
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.55727283
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54195619
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.54113983
146CBX2_22325352_ChIP-Seq_293T-Rex_Human0.50956941
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50819167
148E2F1_20622854_ChIP-Seq_HELA_Human0.49671530
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.49633082
150TET1_21490601_ChIP-Seq_MESCs_Mouse0.48829766
151MYC_18555785_ChIP-Seq_MESCs_Mouse0.48254537
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.46797281
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.46525605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.86358875
2MP0004381_abnormal_hair_follicle4.95575072
3MP0002254_reproductive_system_inflammat4.89969662
4MP0005275_abnormal_skin_tensile4.57991479
5MP0003941_abnormal_skin_development4.42344217
6MP0010234_abnormal_vibrissa_follicle4.14951794
7MP0005501_abnormal_skin_physiology4.06349275
8MP0000383_abnormal_hair_follicle3.49089290
9MP0002060_abnormal_skin_morphology3.39930550
10MP0001216_abnormal_epidermal_layer3.21046040
11MP0010678_abnormal_skin_adnexa3.00954264
12MP0002098_abnormal_vibrissa_morphology2.98726945
13MP0001346_abnormal_lacrimal_gland2.83118579
14MP0010771_integument_phenotype2.81092099
15MP0003453_abnormal_keratinocyte_physiol2.78538431
16MP0000579_abnormal_nail_morphology2.71242904
17MP0000647_abnormal_sebaceous_gland2.52840342
18MP0009379_abnormal_foot_pigmentation2.45473996
19MP0004947_skin_inflammation2.34643981
20MP0005451_abnormal_body_composition2.24294192
21MP0000467_abnormal_esophagus_morphology2.22785349
22MP0000377_abnormal_hair_follicle2.09971226
23MP0009053_abnormal_anal_canal2.09580522
24MP0003136_yellow_coat_color2.07870001
25MP0002009_preneoplasia2.01240358
26MP0000566_synostosis1.89356569
27MP0000427_abnormal_hair_cycle1.81536864
28MP0001191_abnormal_skin_condition1.67481511
29MP0001851_eye_inflammation1.59470669
30MP0009931_abnormal_skin_appearance1.54257595
31MP0003566_abnormal_cell_adhesion1.54008983
32MP0004264_abnormal_extraembryonic_tissu1.53541125
33MP0004272_abnormal_basement_membrane1.45715249
34MP0008004_abnormal_stomach_pH1.42812115
35MP0000762_abnormal_tongue_morphology1.39603521
36MP0003705_abnormal_hypodermis_morpholog1.36954343
37MP0003436_decreased_susceptibility_to1.36821668
38MP0002006_tumorigenesis1.32604552
39MP0000367_abnormal_coat/_hair1.30266421
40* MP0002148_abnormal_hypersensitivity_rea1.24963519
41MP0002877_abnormal_melanocyte_morpholog1.22048807
42MP0004885_abnormal_endolymph1.21363268
43MP0004782_abnormal_surfactant_physiolog1.18898789
44MP0001243_abnormal_dermal_layer1.18666068
45MP0009780_abnormal_chondrocyte_physiolo1.15820104
46MP0004185_abnormal_adipocyte_glucose1.14661280
47MP0001849_ear_inflammation1.14530878
48MP0003950_abnormal_plasma_membrane1.06340260
49MP0002166_altered_tumor_susceptibility1.05741294
50MP0003191_abnormal_cellular_cholesterol1.01959403
51MP0005367_renal/urinary_system_phenotyp1.01225784
52MP0000516_abnormal_urinary_system1.01225784
53MP0003763_abnormal_thymus_physiology1.00531480
54MP0005409_darkened_coat_color0.99963372
55MP0002277_abnormal_respiratory_mucosa0.97133312
56MP0010352_gastrointestinal_tract_polyps0.96494834
57MP0001340_abnormal_eyelid_morphology0.94740319
58MP0000685_abnormal_immune_system0.93848867
59MP0000678_abnormal_parathyroid_gland0.92002200
60MP0008789_abnormal_olfactory_epithelium0.89423591
61MP0003806_abnormal_nucleotide_metabolis0.88904397
62MP0010030_abnormal_orbit_morphology0.87598261
63MP0003755_abnormal_palate_morphology0.86674415
64MP0001835_abnormal_antigen_presentation0.85389261
65MP0002095_abnormal_skin_pigmentation0.84513961
66MP0005000_abnormal_immune_tolerance0.82876879
67MP0005075_abnormal_melanosome_morpholog0.81520715
68MP0000627_abnormal_mammary_gland0.79244244
69MP0005023_abnormal_wound_healing0.78762167
70MP0005647_abnormal_sex_gland0.76069580
71MP0005387_immune_system_phenotype0.75545326
72MP0001790_abnormal_immune_system0.75545326
73MP0005025_abnormal_response_to0.74843185
74MP0005360_urolithiasis0.74642606
75MP0005076_abnormal_cell_differentiation0.74484644
76MP0002132_abnormal_respiratory_system0.72012903
77MP0009785_altered_susceptibility_to0.71756839
78MP0003011_delayed_dark_adaptation0.69797733
79MP0002111_abnormal_tail_morphology0.67425906
80MP0001188_hyperpigmentation0.67345941
81MP0000613_abnormal_salivary_gland0.64506923
82MP0009764_decreased_sensitivity_to0.62743283
83MP0005174_abnormal_tail_pigmentation0.62410282
84MP0002177_abnormal_outer_ear0.61476304
85MP0001984_abnormal_olfaction0.59293536
86MP0008260_abnormal_autophagy0.58684516
87MP0003828_pulmonary_edema0.58134478
88MP0000470_abnormal_stomach_morphology0.57929616
89MP0003183_abnormal_peptide_metabolism0.57612754
90MP0004957_abnormal_blastocyst_morpholog0.57502760
91MP0003724_increased_susceptibility_to0.56532710
92MP0000372_irregular_coat_pigmentation0.56238795
93MP0001800_abnormal_humoral_immune0.55152771
94MP0010155_abnormal_intestine_physiology0.54543630
95MP0000538_abnormal_urinary_bladder0.54028964
96MP0000537_abnormal_urethra_morphology0.53734887
97MP0003786_premature_aging0.53404419
98MP0002419_abnormal_innate_immunity0.53339948
99MP0005394_taste/olfaction_phenotype0.53159369
100MP0005499_abnormal_olfactory_system0.53159369
101MP0003315_abnormal_perineum_morphology0.52484054
102MP0005257_abnormal_intraocular_pressure0.51965744
103MP0002282_abnormal_trachea_morphology0.51571359
104MP0000013_abnormal_adipose_tissue0.51054040
105MP0000465_gastrointestinal_hemorrhage0.49097381
106MP0004019_abnormal_vitamin_homeostasis0.48670578
107MP0005671_abnormal_response_to0.48355303
108* MP0002723_abnormal_immune_serum0.47687332
109MP0001853_heart_inflammation0.47658406
110MP0001873_stomach_inflammation0.47438943
111MP0002452_abnormal_antigen_presenting0.46928415
112MP0005193_abnormal_anterior_eye0.46882390
113MP0003045_fibrosis0.45331809
114MP0001533_abnormal_skeleton_physiology0.45057483
115MP0006082_CNS_inflammation0.44804351
116MP0003448_altered_tumor_morphology0.43705366
117MP0005390_skeleton_phenotype0.43637014
118MP0005508_abnormal_skeleton_morphology0.41612243
119MP0000858_altered_metastatic_potential0.41418505
120MP0002249_abnormal_larynx_morphology0.41405452
121MP0001661_extended_life_span0.41119540
122MP0003693_abnormal_embryo_hatching0.40743597
123MP0005197_abnormal_uvea_morphology0.39812109
124MP0001784_abnormal_fluid_regulation0.39339297
125MP0008438_abnormal_cutaneous_collagen0.39256984
126MP0002234_abnormal_pharynx_morphology0.39159584
127MP0002163_abnormal_gland_morphology0.39094475
128* MP0001819_abnormal_immune_cell0.38876697
129* MP0002420_abnormal_adaptive_immunity0.38076150
130MP0000015_abnormal_ear_pigmentation0.37964745
131MP0004197_abnormal_fetal_growth/weight/0.37747252
132MP0001845_abnormal_inflammatory_respons0.36945345
133MP0002405_respiratory_system_inflammati0.36919632
134MP0005164_abnormal_response_to0.34171000
135MP0005248_abnormal_Harderian_gland0.33327496
136MP0000003_abnormal_adipose_tissue0.31451933
137MP0001299_abnormal_eye_distance/0.30212137
138MP0002233_abnormal_nose_morphology0.29996434
139MP0002896_abnormal_bone_mineralization0.29923670
140MP0002697_abnormal_eye_size0.29443406
141MP0003937_abnormal_limbs/digits/tail_de0.28520380
142MP0005083_abnormal_biliary_tract0.28028274
143MP0000432_abnormal_head_morphology0.26828061
144MP0005621_abnormal_cell_physiology0.26621283
145MP0001186_pigmentation_phenotype0.23724987
146MP0004043_abnormal_pH_regulation0.23405908
147MP0008932_abnormal_embryonic_tissue0.23122899
148MP0005503_abnormal_tendon_morphology0.22516523

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)6.52659569
2Increased IgE level (HP:0003212)6.06498516
3Plantar hyperkeratosis (HP:0007556)5.99296456
4Lip pit (HP:0100267)5.76654695
5Parakeratosis (HP:0001036)5.64167956
6Palmoplantar hyperkeratosis (HP:0000972)5.50749963
7Onycholysis (HP:0001806)5.23210401
8Palmar hyperkeratosis (HP:0010765)5.18940059
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.12682710
10Congenital ichthyosiform erythroderma (HP:0007431)5.03810530
11Oral leukoplakia (HP:0002745)4.95716639
12Woolly hair (HP:0002224)4.94816459
13Fragile nails (HP:0001808)4.93235817
14Erythema (HP:0010783)4.70839001
15Right ventricular cardiomyopathy (HP:0011663)4.57682981
16Erythroderma (HP:0001019)4.41113778
17Milia (HP:0001056)4.31854593
18Thick nail (HP:0001805)4.04224379
19Abnormality of nail color (HP:0100643)3.97434304
20Abnormality of the axillary hair (HP:0100134)3.74665268
21Abnormality of secondary sexual hair (HP:0009888)3.74665268
22Popliteal pterygium (HP:0009756)3.59903220
23Abnormal blistering of the skin (HP:0008066)3.56995946
24Absent eyelashes (HP:0000561)3.50111939
25Hypohidrosis (HP:0000966)3.47337636
26Sparse scalp hair (HP:0002209)3.32655651
27Sparse eyelashes (HP:0000653)3.29338798
28Selective tooth agenesis (HP:0001592)3.28067826
29Ectropion (HP:0000656)3.25855236
30Aplasia cutis congenita (HP:0001057)3.24162819
31Amniotic constriction ring (HP:0009775)3.23156886
32Abnormality of placental membranes (HP:0011409)3.23156886
33Gangrene (HP:0100758)3.21423221
34Corneal erosion (HP:0200020)3.14375553
35Pili torti (HP:0003777)3.12974773
36Natal tooth (HP:0000695)3.06554129
37Oligodontia (HP:0000677)3.04589884
38Dry hair (HP:0011359)3.04262117
39Alopecia of scalp (HP:0002293)3.03213288
40Pruritus (HP:0000989)3.00958038
41Nail dystrophy (HP:0008404)2.96133849
42Distal lower limb muscle weakness (HP:0009053)2.94110830
43Abnormality of cells of the erythroid lineage (HP:0012130)2.89877490
44Conjunctival hamartoma (HP:0100780)2.83498201
45Curly hair (HP:0002212)2.78681509
46Advanced eruption of teeth (HP:0006288)2.78209377
47Reticulocytopenia (HP:0001896)2.71340492
48Fatigable weakness (HP:0003473)2.67801139
49Abnormality of the neuromuscular junction (HP:0003398)2.67801139
50Acanthosis nigricans (HP:0000956)2.66693220
51Atrophic scars (HP:0001075)2.63956007
52Eczematoid dermatitis (HP:0000976)2.59832098
53Anhidrosis (HP:0000970)2.59127444
54Ridged nail (HP:0001807)2.58955557
55Anonychia (HP:0001798)2.58408012
56Ventricular tachycardia (HP:0004756)2.56966189
57Concave nail (HP:0001598)2.54377822
58Pustule (HP:0200039)2.50616491
59Abnormal number of erythroid precursors (HP:0012131)2.50274981
60Conical tooth (HP:0000698)2.47474892
61Hypoplasia of dental enamel (HP:0006297)2.46314555
62Absent hair (HP:0002298)2.46109160
63Duplicated collecting system (HP:0000081)2.43964005
64Palmoplantar keratoderma (HP:0000982)2.42902755
65Congenital, generalized hypertrichosis (HP:0004540)2.40848198
66Hypergammaglobulinemia (HP:0010702)2.37270510
67Absent eyebrow (HP:0002223)2.34675632
68Breast hypoplasia (HP:0003187)2.32674027
69Follicular hyperkeratosis (HP:0007502)2.31895688
70Hyperhidrosis (HP:0000975)2.31423047
71Abnormal hemoglobin (HP:0011902)2.30460583
72Ankyloglossia (HP:0010296)2.29675943
73Carious teeth (HP:0000670)2.29670420
74Premature loss of primary teeth (HP:0006323)2.28350240
75Septate vagina (HP:0001153)2.21642488
76Abnormality of the gastric mucosa (HP:0004295)2.20036711
77Labial hypoplasia (HP:0000066)2.19681496
78Squamous cell carcinoma (HP:0002860)2.19190113
79Split foot (HP:0001839)2.15407333
80Hyporeflexia of lower limbs (HP:0002600)2.11961033
81Hypoplastic labia majora (HP:0000059)2.11151089
82Dry skin (HP:0000958)2.10028391
83Abnormality of the renal collecting system (HP:0004742)2.08511175
84Hypoplastic female external genitalia (HP:0012815)2.06385199
85Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.05920626
86Xerostomia (HP:0000217)2.05536393
87Abnormality of the salivary glands (HP:0010286)2.05278554
88Prostate neoplasm (HP:0100787)2.03653820
89Blepharitis (HP:0000498)2.02720605
90Stenosis of the external auditory canal (HP:0000402)2.01941265
91White forelock (HP:0002211)1.99178724
92Corneal dystrophy (HP:0001131)1.98963906
93Abnormality of the fingernails (HP:0001231)1.98392564
94Recurrent corneal erosions (HP:0000495)1.96235508
95Orchitis (HP:0100796)1.93978136
96Abnormality of the labia majora (HP:0012881)1.92510225
97Skin ulcer (HP:0200042)1.91898875
98Epidermoid cyst (HP:0200040)1.91317785
99Hypodontia (HP:0000668)1.88569887
100Obstructive sleep apnea (HP:0002870)1.87037854
101Pallor (HP:0000980)1.86721594
102Areflexia of lower limbs (HP:0002522)1.86652620
103Ureteral duplication (HP:0000073)1.84034976
104Depressed nasal tip (HP:0000437)1.83156031
105Abnormal hair laboratory examination (HP:0003328)1.81541644
106Type I diabetes mellitus (HP:0100651)1.81527622
107Pterygium (HP:0001059)1.81140658
108Malignant hyperthermia (HP:0002047)1.79894375
109Patchy hypopigmentation of hair (HP:0011365)1.79683134
110Hypoplasia of the uterus (HP:0000013)1.78847623
111Cheilitis (HP:0100825)1.77468985
112Amelogenesis imperfecta (HP:0000705)1.76879229
113Autoamputation (HP:0001218)1.76211861
114Autoimmune hemolytic anemia (HP:0001890)1.73880477
115Slow-growing hair (HP:0002217)1.73374162
116Abnormality of hair growth rate (HP:0011363)1.73374162
117Fragile skin (HP:0001030)1.73159695
118Chronic otitis media (HP:0000389)1.72139901
119Abnormality of the nasal septum (HP:0000419)1.72126920
120Abnormality of the distal phalanges of the toes (HP:0010182)1.71417232
121Skin pits (HP:0100276)1.70986865
122Abnormality of the dental root (HP:0006486)1.70822225
123Taurodontia (HP:0000679)1.70822225
124Abnormality of permanent molar morphology (HP:0011071)1.70822225
125Macrocytic anemia (HP:0001972)1.70001981
126Abnormality of oral frenula (HP:0000190)1.69677843
127Brittle hair (HP:0002299)1.69565271
128Urticaria (HP:0001025)1.68653852
129Abnormality of the lacrimal duct (HP:0011481)1.66143968
130Furrowed tongue (HP:0000221)1.65904010
131Multifactorial inheritance (HP:0001426)1.65499882
132Optic neuritis (HP:0100653)1.64791705
133Retrobulbar optic neuritis (HP:0100654)1.64791705
134Myositis (HP:0100614)1.64192555
135Dehydration (HP:0001944)1.63679079
136Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63132158
137Severe Myopia (HP:0011003)1.62341453
138Laryngomalacia (HP:0001601)1.62306739
139Nasolacrimal duct obstruction (HP:0000579)1.61634990
140Abnormality of molar (HP:0011077)1.58686038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.97029332
2TGFBR13.59192592
3MST43.41852069
4MAP3K33.29209518
5MAPKAPK33.25423263
6MAP3K142.77148997
7ERBB32.50806276
8TRPM72.45422885
9MAP3K92.41873430
10IRAK32.41871778
11MAP3K22.40960628
12ARAF2.37829391
13MAP3K62.20811943
14NTRK12.16874660
15FER2.16699021
16FLT32.15491102
17EPHB22.13403738
18LMTK21.87713182
19TYK21.86327930
20PIK3CG1.84825705
21CDK31.80497679
22PTK21.74120488
23EPHA31.73832887
24STK241.71029909
25RIPK41.70721357
26SIK11.70078228
27LATS21.63974486
28RPS6KB21.61487246
29MAPKAPK51.58974157
30IRAK41.54412721
31FGFR21.53481770
32LATS11.51023621
33BMPR21.50176781
34PIM21.49557692
35IKBKE1.40073464
36TLK11.38162634
37MET1.35553536
38FGFR41.35342895
39RIPK11.33480137
40PDGFRA1.29366973
41STK101.26140303
42IKBKB1.22843725
43FGFR31.22108178
44STK38L1.21399573
45IRAK11.19821928
46INSRR1.16773094
47MOS1.13649619
48NTRK21.12847165
49NME21.12422996
50TGFBR21.12143433
51BLK1.11200904
52EIF2AK21.08524468
53CASK1.08492346
54GRK11.06686771
55DYRK1B1.01958662
56ITK1.01715949
57ERN11.00351977
58LRRK20.99374071
59EEF2K0.97399800
60GRK70.97255395
61MAP3K120.95319139
62NEK10.91707095
63BMX0.89156641
64PRPF4B0.87851086
65PTK60.85106820
66JAK10.83579643
67PDGFRB0.82991977
68PDK20.79100895
69TNK20.78740132
70MAP3K130.77459050
71DYRK30.75783726
72EPHB10.75739353
73CHUK0.75722566
74BCR0.75510468
75RPS6KA40.74706640
76HCK0.74576265
77MAPK70.74504922
78PAK40.71815992
79SIK30.71672756
80TTK0.71510186
81MAPKAPK20.70859660
82YES10.67404324
83BRAF0.67095221
84EIF2AK30.67070859
85EPHA20.66393395
86MAP2K60.66236299
87ZAK0.63946124
88RAF10.63540943
89TBK10.62500328
90HIPK20.61274705
91PBK0.61260331
92KSR20.60985193
93FGFR10.60620621
94SYK0.60394109
95ABL20.60034567
96FRK0.59076298
97PRKCE0.58569565
98PRKCI0.57988159
99TAOK20.56031970
100CDK60.54486600
101NME10.53966023
102TXK0.53848144
103MAP3K10.52783644
104JAK20.51874868
105BTK0.50993169
106MAPK150.50748950
107JAK30.50631460
108NLK0.50001400
109BUB10.49335336
110BMPR1B0.47901610
111STK390.47113446
112MATK0.46646663
113MUSK0.45984803
114WNK40.43652008
115ILK0.41530584
116RPS6KB10.41511686
117STK380.41145107
118ABL10.39417840
119PHKG10.39330266
120PHKG20.39330266
121RPS6KC10.37805171
122RPS6KL10.37805171
123ERBB40.36046106
124STK30.35029090
125DYRK1A0.34959339
126EIF2AK10.32481634
127RPS6KA60.32030128
128PRKD10.31772110
129TEC0.30709065
130IGF1R0.30566684
131LCK0.30164302
132MAP3K70.30073500
133ERBB20.30022762
134ADRBK10.29128382
135PRKCD0.28515187
136TESK10.27604965
137TIE10.27439052
138IRAK20.27415459
139OBSCN0.26885714
140MAP2K20.26137969
141GRK50.25358079
142NEK60.24163757
143PAK20.21910522
144WNK10.20701749
145MTOR0.20550954
146AURKB0.19491237
147MAP3K80.18806236
148KSR10.18471293
149RPS6KA20.18132518
150PRKD20.16913790
151TESK20.16025069
152AURKA0.15366933
153MAP2K10.15011169

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.47831458
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98471648
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.91033398
4Ribosome_Homo sapiens_hsa030102.70345875
5Sphingolipid metabolism_Homo sapiens_hsa006002.55850210
6Graft-versus-host disease_Homo sapiens_hsa053322.34630395
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04903794
8Steroid biosynthesis_Homo sapiens_hsa001002.02846465
9Arachidonic acid metabolism_Homo sapiens_hsa005901.91997468
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86813916
11Linoleic acid metabolism_Homo sapiens_hsa005911.84123930
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78220968
13Focal adhesion_Homo sapiens_hsa045101.64705078
14Bladder cancer_Homo sapiens_hsa052191.58812757
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58342149
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54814082
17Circadian rhythm_Homo sapiens_hsa047101.47527645
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.45852138
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44901955
20Leishmaniasis_Homo sapiens_hsa051401.41080547
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37801837
22Staphylococcus aureus infection_Homo sapiens_hsa051501.36300987
23Arginine biosynthesis_Homo sapiens_hsa002201.36067133
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.33202166
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32498800
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30161780
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26630395
28Dorso-ventral axis formation_Homo sapiens_hsa043201.24507478
29Histidine metabolism_Homo sapiens_hsa003401.19801695
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18807617
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18052935
32Pertussis_Homo sapiens_hsa051331.17011828
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14994211
34TNF signaling pathway_Homo sapiens_hsa046681.14358339
35Phenylalanine metabolism_Homo sapiens_hsa003601.12442923
36Primary immunodeficiency_Homo sapiens_hsa053401.09312465
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07739401
38Osteoclast differentiation_Homo sapiens_hsa043801.07369133
39Thyroid cancer_Homo sapiens_hsa052161.06140523
40One carbon pool by folate_Homo sapiens_hsa006701.04552944
41Basal cell carcinoma_Homo sapiens_hsa052171.04214888
42Sulfur metabolism_Homo sapiens_hsa009201.03562323
43Malaria_Homo sapiens_hsa051441.03099423
44Hematopoietic cell lineage_Homo sapiens_hsa046401.01429462
45Tuberculosis_Homo sapiens_hsa051520.98494606
46Taste transduction_Homo sapiens_hsa047420.97877985
47Toxoplasmosis_Homo sapiens_hsa051450.97365937
48Allograft rejection_Homo sapiens_hsa053300.96697749
49ErbB signaling pathway_Homo sapiens_hsa040120.96636542
50Adherens junction_Homo sapiens_hsa045200.95921266
51Ether lipid metabolism_Homo sapiens_hsa005650.95620885
52Fatty acid elongation_Homo sapiens_hsa000620.95280288
53Amoebiasis_Homo sapiens_hsa051460.94760877
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.93497522
55Rheumatoid arthritis_Homo sapiens_hsa053230.92659823
56Long-term depression_Homo sapiens_hsa047300.90274665
57Serotonergic synapse_Homo sapiens_hsa047260.90182976
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89838292
59p53 signaling pathway_Homo sapiens_hsa041150.89789009
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89303605
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89154372
62Pancreatic secretion_Homo sapiens_hsa049720.88669077
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88255959
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87792517
65African trypanosomiasis_Homo sapiens_hsa051430.87735532
66Measles_Homo sapiens_hsa051620.86229016
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86060755
68* Jak-STAT signaling pathway_Homo sapiens_hsa046300.85920284
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84600936
70GnRH signaling pathway_Homo sapiens_hsa049120.84269471
71Pathways in cancer_Homo sapiens_hsa052000.84201471
72N-Glycan biosynthesis_Homo sapiens_hsa005100.83037173
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82413538
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.81402996
75Legionellosis_Homo sapiens_hsa051340.80896104
76Hepatitis C_Homo sapiens_hsa051600.80529532
77Proteoglycans in cancer_Homo sapiens_hsa052050.79985957
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79540843
79Influenza A_Homo sapiens_hsa051640.79492182
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.79482539
81Asthma_Homo sapiens_hsa053100.79232046
82VEGF signaling pathway_Homo sapiens_hsa043700.78668728
83Renin secretion_Homo sapiens_hsa049240.78400356
84Nucleotide excision repair_Homo sapiens_hsa034200.77878336
85Inositol phosphate metabolism_Homo sapiens_hsa005620.75647441
86MicroRNAs in cancer_Homo sapiens_hsa052060.75154289
87Protein export_Homo sapiens_hsa030600.74399487
88ECM-receptor interaction_Homo sapiens_hsa045120.74016762
89Salmonella infection_Homo sapiens_hsa051320.73902096
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73741747
91Antigen processing and presentation_Homo sapiens_hsa046120.73683144
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73032767
93Chemokine signaling pathway_Homo sapiens_hsa040620.72625033
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.72251691
95Vitamin B6 metabolism_Homo sapiens_hsa007500.71825442
96Melanogenesis_Homo sapiens_hsa049160.71456163
97Calcium signaling pathway_Homo sapiens_hsa040200.69461762
98Endocytosis_Homo sapiens_hsa041440.68843237
99Ovarian steroidogenesis_Homo sapiens_hsa049130.68343218
100Glutamatergic synapse_Homo sapiens_hsa047240.68030699
101Axon guidance_Homo sapiens_hsa043600.67674569
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67253670
103Basal transcription factors_Homo sapiens_hsa030220.66932563
104Glioma_Homo sapiens_hsa052140.66242635
105T cell receptor signaling pathway_Homo sapiens_hsa046600.65910111
106Herpes simplex infection_Homo sapiens_hsa051680.65558993
107Apoptosis_Homo sapiens_hsa042100.64766959
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64651976
109Salivary secretion_Homo sapiens_hsa049700.64557559
110Ras signaling pathway_Homo sapiens_hsa040140.64545048
111ABC transporters_Homo sapiens_hsa020100.63826426
112Retinol metabolism_Homo sapiens_hsa008300.63051898
113Nicotine addiction_Homo sapiens_hsa050330.62598723
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62104248
115Platelet activation_Homo sapiens_hsa046110.62049607
116Hippo signaling pathway_Homo sapiens_hsa043900.61665110
117Autoimmune thyroid disease_Homo sapiens_hsa053200.60675962
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60528993
119Fatty acid biosynthesis_Homo sapiens_hsa000610.60154880
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59387258
121Shigellosis_Homo sapiens_hsa051310.57927904
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57176770
123Phototransduction_Homo sapiens_hsa047440.55619731
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55583794
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55555441
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54793418
127Mineral absorption_Homo sapiens_hsa049780.54736765
128Protein digestion and absorption_Homo sapiens_hsa049740.53695077
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53588016
130Collecting duct acid secretion_Homo sapiens_hsa049660.53226634
131Phagosome_Homo sapiens_hsa041450.52928894
132Glycerolipid metabolism_Homo sapiens_hsa005610.52889351
133Tyrosine metabolism_Homo sapiens_hsa003500.52418201
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.51686400
135Circadian entrainment_Homo sapiens_hsa047130.51672537
136Small cell lung cancer_Homo sapiens_hsa052220.51609735
137Tight junction_Homo sapiens_hsa045300.51344406
138Chemical carcinogenesis_Homo sapiens_hsa052040.51243031
139Insulin signaling pathway_Homo sapiens_hsa049100.50083083
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49470972
141Gastric acid secretion_Homo sapiens_hsa049710.48824523
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48509503
143Renal cell carcinoma_Homo sapiens_hsa052110.48483669
144RNA transport_Homo sapiens_hsa030130.48441285
145Glutathione metabolism_Homo sapiens_hsa004800.48431208
146TGF-beta signaling pathway_Homo sapiens_hsa043500.47500864
147Notch signaling pathway_Homo sapiens_hsa043300.47267323
148Pancreatic cancer_Homo sapiens_hsa052120.45779511
149Choline metabolism in cancer_Homo sapiens_hsa052310.42488689
150Cell cycle_Homo sapiens_hsa041100.42308260
151Chronic myeloid leukemia_Homo sapiens_hsa052200.40900208
152Melanoma_Homo sapiens_hsa052180.39408256
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37021861
154Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35960382
155Arginine and proline metabolism_Homo sapiens_hsa003300.35398228
156Metabolic pathways_Homo sapiens_hsa011000.34034424
157Dilated cardiomyopathy_Homo sapiens_hsa054140.33540150
158Biosynthesis of amino acids_Homo sapiens_hsa012300.28508644
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28027474
160Galactose metabolism_Homo sapiens_hsa000520.25359533

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