IL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-2 biosynthetic process (GO:0045076)8.91168200
2tolerance induction (GO:0002507)8.75657621
3cytokine biosynthetic process (GO:0042089)8.64742338
4positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)8.25918565
5regulation of immunoglobulin secretion (GO:0051023)8.12367876
6regulation of interleukin-12 biosynthetic process (GO:0045075)7.57429441
7regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.45706950
8positive regulation of interleukin-17 production (GO:0032740)7.40312152
9negative regulation of interleukin-10 production (GO:0032693)7.39429527
10positive regulation of defense response to virus by host (GO:0002230)7.34808605
11cytokine metabolic process (GO:0042107)7.05064854
12T-helper cell differentiation (GO:0042093)6.85189625
13CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)6.85189625
14regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)6.76599574
15negative regulation of thymocyte apoptotic process (GO:0070244)6.67536765
16positive regulation of activated T cell proliferation (GO:0042104)6.67056348
17positive regulation of T cell mediated cytotoxicity (GO:0001916)6.59412420
18positive regulation of cell fate commitment (GO:0010455)6.46176356
19cellular response to interleukin-15 (GO:0071350)6.40043514
20response to interleukin-15 (GO:0070672)6.31313833
21positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.29172976
22regulation of T cell mediated cytotoxicity (GO:0001914)6.23845260
23positive regulation of T-helper 1 type immune response (GO:0002827)6.03519421
24very-low-density lipoprotein particle assembly (GO:0034379)5.98067925
25T cell differentiation involved in immune response (GO:0002292)5.92516958
26alpha-beta T cell differentiation involved in immune response (GO:0002293)5.92516958
27alpha-beta T cell activation involved in immune response (GO:0002287)5.92516958
28interferon-gamma production (GO:0032609)5.85359400
29positive regulation of T-helper cell differentiation (GO:0045624)5.84485145
30myeloid dendritic cell differentiation (GO:0043011)5.79300641
31viral protein processing (GO:0019082)5.69015181
32DNA double-strand break processing (GO:0000729)5.63495889
33positive regulation of transcription regulatory region DNA binding (GO:2000679)5.49222578
34positive regulation of osteoclast differentiation (GO:0045672)5.36932344
35regulation of transforming growth factor beta1 production (GO:0032908)5.15110874
36regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.14081235
37positive regulation of T cell cytokine production (GO:0002726)5.09357448
38regulation of interleukin-2 production (GO:0032663)5.07497778
39positive regulation of natural killer cell activation (GO:0032816)4.99004011
40T-helper 1 type immune response (GO:0042088)4.92525094
41positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.89397198
42regulation of activated T cell proliferation (GO:0046006)4.76887795
43myeloid dendritic cell activation (GO:0001773)4.74014631
44autophagic vacuole fusion (GO:0000046)4.68660654
45CD4-positive, alpha-beta T cell differentiation (GO:0043367)4.64932477
46regulation of T-helper 1 type immune response (GO:0002825)4.64289971
47signal peptide processing (GO:0006465)4.51100807
48regulation of T-helper cell differentiation (GO:0045622)4.50084168
49positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.47206917
50regulation of defense response to virus by host (GO:0050691)4.42292655
51regulation of cholesterol homeostasis (GO:2000188)4.39144710
52regulation of leukocyte mediated cytotoxicity (GO:0001910)4.34426590
53positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.32925982
54regulation of interleukin-17 production (GO:0032660)4.32579600
55CD4-positive, alpha-beta T cell activation (GO:0035710)4.24779257
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.21873903
57diacylglycerol metabolic process (GO:0046339)4.14366064
58positive regulation of cell killing (GO:0031343)4.13593229
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.11627111
60alpha-beta T cell differentiation (GO:0046632)4.07408835
61regulation of cell killing (GO:0031341)4.03150584
62regulation of gamma-delta T cell differentiation (GO:0045586)4.02681681
63mucosal-associated lymphoid tissue development (GO:0048537)4.02370575
64Peyers patch development (GO:0048541)4.02370575
65regulation of thymocyte apoptotic process (GO:0070243)4.00775291
66leukocyte aggregation (GO:0070486)3.97863635
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88729996
68virion assembly (GO:0019068)3.87077837
69macroautophagy (GO:0016236)3.86095234
70regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.85915694
71growth hormone receptor signaling pathway (GO:0060396)3.85298498
72T cell activation involved in immune response (GO:0002286)3.84675274
73NIK/NF-kappaB signaling (GO:0038061)3.80564749
74regulation of vitamin D biosynthetic process (GO:0060556)3.80184366
75interleukin-1-mediated signaling pathway (GO:0070498)3.76966844
76plasma lipoprotein particle assembly (GO:0034377)3.76376833
77alpha-beta T cell activation (GO:0046631)3.72385779
78regulation of natural killer cell activation (GO:0032814)3.71479891
79DNA deamination (GO:0045006)3.69139668
80regulation of T cell cytokine production (GO:0002724)3.68580447
81ether lipid metabolic process (GO:0046485)3.67583737
82organelle membrane fusion (GO:0090174)3.65286572
83mature B cell differentiation involved in immune response (GO:0002313)3.63489856
84cytidine metabolic process (GO:0046087)3.57963021
85cytidine catabolic process (GO:0006216)3.57963021
86cytidine deamination (GO:0009972)3.57963021
87regulation of T-helper 1 cell differentiation (GO:0045625)3.57913840
88positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.56159710
89poly(A)+ mRNA export from nucleus (GO:0016973)3.53692775
90regulation of gamma-delta T cell activation (GO:0046643)3.51392651
91pyrimidine ribonucleoside catabolic process (GO:0046133)3.50048874
92positive regulation of T cell mediated immunity (GO:0002711)3.45349055
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44928891
94negative regulation of cell killing (GO:0031342)3.44928891
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44245976
96protein carboxylation (GO:0018214)3.43873255
97peptidyl-glutamic acid carboxylation (GO:0017187)3.43873255
98inflammatory response to antigenic stimulus (GO:0002437)3.42047630
99protein-lipid complex assembly (GO:0065005)3.40529302
100regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.36640111
101regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.35200976
102T cell apoptotic process (GO:0070231)3.29954515
103positive regulation of interleukin-2 production (GO:0032743)3.27669721
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.27660467
105cellular response to interleukin-1 (GO:0071347)3.27254132
106regulation of immunoglobulin production (GO:0002637)3.26762493
107cellular response to growth hormone stimulus (GO:0071378)3.26122483
108regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.26094349
109polyamine biosynthetic process (GO:0006596)3.24007469
110activated T cell proliferation (GO:0050798)3.23460071
111lymphocyte apoptotic process (GO:0070227)3.22492208
112regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.21738743
113positive regulation of interferon-gamma production (GO:0032729)3.21165392
114positive regulation of alpha-beta T cell differentiation (GO:0046638)3.18315593
115leukocyte apoptotic process (GO:0071887)3.16930699
116positive regulation of myeloid leukocyte differentiation (GO:0002763)3.16275311
117positive regulation of gamma-delta T cell activation (GO:0046645)3.15972674
118positive regulation of interleukin-12 production (GO:0032735)3.15660363
119defense response to Gram-negative bacterium (GO:0050829)3.15130286
120lipid storage (GO:0019915)3.15127411
121regulation of response to interferon-gamma (GO:0060330)3.14711195
122regulation of regulatory T cell differentiation (GO:0045589)3.13710353
123regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.13272933
124negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.12087985
125regulation of T cell mediated immunity (GO:0002709)3.05795925
126dendritic cell differentiation (GO:0097028)3.03855647
127negative regulation of inclusion body assembly (GO:0090084)3.02010827
128positive regulation of keratinocyte differentiation (GO:0045618)3.01557085
129regulation of fever generation (GO:0031620)3.00845045
130regulation of interleukin-8 production (GO:0032677)3.00702701
131positive regulation of p38MAPK cascade (GO:1900745)3.00114773
132regulation of cytokine production involved in inflammatory response (GO:1900015)23.0294914
133positive regulation of heat generation (GO:0031652)2.95868058
134regulation of vitamin metabolic process (GO:0030656)2.95459298
135negative regulation of erythrocyte differentiation (GO:0045647)2.95315436
136mature B cell differentiation (GO:0002335)2.93345983
137mast cell activation involved in immune response (GO:0002279)2.92307238
138mast cell degranulation (GO:0043303)2.92307238
139valine metabolic process (GO:0006573)2.91710048
140somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91395453
141somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91395453
142isotype switching (GO:0045190)2.91395453
143natural killer cell activation (GO:0030101)2.90952452
144response to interferon-alpha (GO:0035455)2.89376322
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87883439
146negative regulation of T-helper cell differentiation (GO:0045623)2.87883439
147positive regulation of T cell differentiation (GO:0045582)2.86520233
148regulation of osteoclast differentiation (GO:0045670)2.85013894
149regulation of isotype switching to IgG isotypes (GO:0048302)2.81327890
150T cell differentiation (GO:0030217)2.81187295
151nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.81005780
152regulation of alpha-beta T cell differentiation (GO:0046637)2.79378292
153regulation of glycogen (starch) synthase activity (GO:2000465)2.78843890
154positive regulation of B cell differentiation (GO:0045579)2.77853691
155positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.77316516
156positive regulation of prostaglandin secretion (GO:0032308)2.72740615
157regulation of interleukin-12 production (GO:0032655)2.71607135
158Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67618540
159positive regulation of inflammatory response (GO:0050729)2.67173787
160positive regulation of bone resorption (GO:0045780)2.65772780
161proteoglycan metabolic process (GO:0006029)2.64570028
162negative regulation of T cell apoptotic process (GO:0070233)2.62818794
163regulation of transforming growth factor beta2 production (GO:0032909)2.56784159
164leukocyte degranulation (GO:0043299)2.54797729
165activation of NF-kappaB-inducing kinase activity (GO:0007250)2.54032321
166cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.51024465
167positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.48046399
168regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.48046399
169UV protection (GO:0009650)2.47189874
170positive regulation of myeloid cell differentiation (GO:0045639)2.46429540
171membrane protein intracellular domain proteolysis (GO:0031293)2.46092473
172cellular response to interferon-alpha (GO:0035457)2.41999115
173regulation of interleukin-6 production (GO:0032675)2.41128854
174positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.40583088
175positive regulation of leukocyte differentiation (GO:1902107)2.40414951
176regulation of interleukin-6 biosynthetic process (GO:0045408)12.9165578
177regulation of activation of Janus kinase activity (GO:0010533)12.7606942
178regulation of memory T cell differentiation (GO:0043380)12.4726883
179regulation of interleukin-8 biosynthetic process (GO:0045414)11.5712419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.06082102
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.72825789
3FLI1_27457419_Chip-Seq_LIVER_Mouse6.40563234
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.04612475
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.72395440
6PCGF2_27294783_Chip-Seq_ESCs_Mouse4.92672870
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.82874351
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.62832266
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.64035265
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.59252946
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.57875075
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.99754313
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.99366376
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.97268908
15CLOCK_20551151_ChIP-Seq_293T_Human2.55808454
16TCF7_22412390_ChIP-Seq_EML_Mouse2.54151017
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46588259
18MYB_26560356_Chip-Seq_TH2_Human2.42792112
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37830857
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26096891
21RUNX_20019798_ChIP-Seq_JUKART_Human2.26037241
22ZNF274_21170338_ChIP-Seq_K562_Hela2.23528877
23MYB_26560356_Chip-Seq_TH1_Human2.21106650
24MAF_26560356_Chip-Seq_TH1_Human2.18613926
25EZH2_27294783_Chip-Seq_NPCs_Mouse2.13979535
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10120274
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.08939003
28MYC_22102868_ChIP-Seq_BL_Human2.08579430
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99087711
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99076688
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98652445
32KDM2B_26808549_Chip-Seq_DND41_Human1.96009617
33SMAD1_18555785_Chip-Seq_ESCs_Mouse1.93300783
34OCT4_18555785_Chip-Seq_ESCs_Mouse1.92017929
35CTCF_18555785_Chip-Seq_ESCs_Mouse1.91636982
36P300_18555785_Chip-Seq_ESCs_Mouse1.90478153
37SOX2_18555785_Chip-Seq_ESCs_Mouse1.86304422
38EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.84766725
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83819933
40NMYC_18555785_Chip-Seq_ESCs_Mouse1.83425988
41KLF4_18555785_Chip-Seq_ESCs_Mouse1.82015725
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.80941735
43RUNX1_27457419_Chip-Seq_LIVER_Mouse1.78302398
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77240526
45UTX_26944678_Chip-Seq_JUKART_Human1.77086240
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75641856
47ZFX_18555785_Chip-Seq_ESCs_Mouse1.73282083
48PU1_27457419_Chip-Seq_LIVER_Mouse1.72649161
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.72168357
50VDR_22108803_ChIP-Seq_LS180_Human1.69930975
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69243788
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.69167612
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.69064687
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68943936
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68587415
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67987160
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67753932
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65694612
59ESRRB_18555785_Chip-Seq_ESCs_Mouse1.65550659
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.62201725
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.61066855
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60758948
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.60231441
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56388237
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.56058625
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.55063295
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.52558700
68P53_22387025_ChIP-Seq_ESCs_Mouse1.52169441
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50241399
70VDR_21846776_ChIP-Seq_THP-1_Human1.47800641
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46940207
72GATA3_27048872_Chip-Seq_THYMUS_Human1.45368290
73* CRX_20693478_ChIP-Seq_RETINA_Mouse1.44698869
74HTT_18923047_ChIP-ChIP_STHdh_Human1.44596259
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44307478
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.43690725
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42137158
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41762533
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.41516009
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.39681037
81* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36960612
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.35024081
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34851154
84VDR_24763502_ChIP-Seq_THP-1_Human1.34730913
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34299296
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34127000
87* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.33773771
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33240071
89MAF_26560356_Chip-Seq_TH2_Human1.30038612
90VDR_24787735_ChIP-Seq_THP-1_Human1.29904196
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28964007
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.27483501
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27143971
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.25969938
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.24324670
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.24068490
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23943587
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18015811
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.16651371
100* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15663300
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15106586
102PU_27001747_Chip-Seq_BMDM_Mouse1.15086467
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14217662
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12784757
105VDR_23849224_ChIP-Seq_CD4+_Human1.12717899
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12659386
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12319533
108* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07550250
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05744129
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05577835
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04547466
112EST1_17652178_ChIP-ChIP_JURKAT_Human1.04539336
113EGR1_19032775_ChIP-ChIP_M12_Human1.03333715
114ATF3_27146783_Chip-Seq_COLON_Human1.02442504
115KDM2B_26808549_Chip-Seq_K562_Human1.00908596
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00606116
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99623590
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99623590
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99583103
120PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99489827
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98844191
122SCL_19346495_ChIP-Seq_HPC-7_Human0.98485933
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97799022
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.96566638
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96391422
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96170263
127FOXP3_21729870_ChIP-Seq_TREG_Human0.95634862
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95053058
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.94872814
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.94508773
131KDM5A_27292631_Chip-Seq_BREAST_Human0.93565281
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.92872231
133GATA1_19941826_ChIP-Seq_K562_Human0.92802481
134GATA2_19941826_ChIP-Seq_K562_Human0.92485713
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92264857
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91843948
137* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89880698
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89834115
139NCOR1_26117541_ChIP-Seq_K562_Human0.89066491
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89018181
141GATA3_26560356_Chip-Seq_TH2_Human0.88450013
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88433276
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85469348
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85452048
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85378219
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.85369978
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84507612
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84182871
149CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83704500
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83658153
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82820670
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82773889
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82560972
154IGF1R_20145208_ChIP-Seq_DFB_Human0.82403049
155ELK1_19687146_ChIP-ChIP_HELA_Human0.82396062
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82177018
157ETS1_20019798_ChIP-Seq_JURKAT_Human0.79904279
158ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75871997
159IRF1_19129219_ChIP-ChIP_H3396_Human0.75297762
160TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72248451
161FOXA1_25329375_ChIP-Seq_VCAP_Human0.68053675
162FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68053675
163PADI4_21655091_ChIP-ChIP_MCF-7_Human0.67790934
164DCP1A_22483619_ChIP-Seq_HELA_Human0.61193988
165ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60685669
166TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.60545704
167SOX2_19829295_ChIP-Seq_ESCs_Human0.59645412
168NANOG_19829295_ChIP-Seq_ESCs_Human0.59645412
169SRF_21415370_ChIP-Seq_HL-1_Mouse0.59578350
170STAT1_20625510_ChIP-Seq_HELA_Human0.59117075
171CEBPB_22108803_ChIP-Seq_LS180_Human0.58932108
172POU3F2_20337985_ChIP-ChIP_501MEL_Human0.57026282
173UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.56762136
174BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.54794158
175PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.54425633
176TP53_16413492_ChIP-PET_HCT116_Human0.53976594
177MYC_18940864_ChIP-ChIP_HL60_Human0.53876342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation6.39826925
2MP0003300_gastrointestinal_ulcer3.67690406
3MP0003724_increased_susceptibility_to3.46326095
4MP0003303_peritoneal_inflammation3.41697237
5MP0004510_myositis3.27188382
6MP0003806_abnormal_nucleotide_metabolis2.86992461
7MP0010352_gastrointestinal_tract_polyps2.74327409
8MP0008961_abnormal_basal_metabolism2.72705025
9MP0008875_abnormal_xenobiotic_pharmacok2.72375530
10MP0005671_abnormal_response_to2.72359921
11MP0003866_abnormal_defecation2.70571249
12MP0005083_abnormal_biliary_tract2.70118389
13MP0004264_abnormal_extraembryonic_tissu2.66057260
14MP0005387_immune_system_phenotype2.65259093
15MP0001790_abnormal_immune_system2.65259093
16MP0002405_respiratory_system_inflammati2.63348168
17MP0005000_abnormal_immune_tolerance2.62513800
18MP0002277_abnormal_respiratory_mucosa2.50688915
19* MP0002723_abnormal_immune_serum2.42064742
20MP0000372_irregular_coat_pigmentation2.40147289
21MP0003638_abnormal_response/metabolism_2.31914908
22MP0001800_abnormal_humoral_immune2.31491230
23* MP0010155_abnormal_intestine_physiology2.26180885
24MP0000685_abnormal_immune_system2.21772313
25MP0003436_decreased_susceptibility_to2.10175461
26MP0001819_abnormal_immune_cell2.06436764
27MP0001502_abnormal_circadian_rhythm2.03781842
28MP0005187_abnormal_penis_morphology2.03402967
29MP0002420_abnormal_adaptive_immunity2.01834099
30MP0005076_abnormal_cell_differentiation1.96513416
31MP0002452_abnormal_antigen_presenting1.94782703
32MP0001881_abnormal_mammary_gland1.93821102
33MP0004947_skin_inflammation1.84332102
34MP0002419_abnormal_innate_immunity1.75921243
35MP0009278_abnormal_bone_marrow1.72717993
36MP0002398_abnormal_bone_marrow1.71303437
37MP0002877_abnormal_melanocyte_morpholog1.71201893
38MP0000716_abnormal_immune_system1.69873784
39* MP0009785_altered_susceptibility_to1.65541590
40MP0003763_abnormal_thymus_physiology1.61933931
41MP0000465_gastrointestinal_hemorrhage1.61021301
42MP0002138_abnormal_hepatobiliary_system1.60554036
43MP0005310_abnormal_salivary_gland1.55310818
44MP0005397_hematopoietic_system_phenotyp1.54948924
45MP0001545_abnormal_hematopoietic_system1.54948924
46* MP0001845_abnormal_inflammatory_respons1.53761491
47MP0009333_abnormal_splenocyte_physiolog1.52506739
48MP0002722_abnormal_immune_system1.46969905
49MP0001663_abnormal_digestive_system1.44755277
50MP0002998_abnormal_bone_remodeling1.44243152
51* MP0005025_abnormal_response_to1.43221949
52MP0002254_reproductive_system_inflammat1.42687092
53MP0000703_abnormal_thymus_morphology1.41375300
54MP0002876_abnormal_thyroid_physiology1.40520826
55MP0008569_lethality_at_weaning1.39170223
56MP0000003_abnormal_adipose_tissue1.37599138
57MP0001986_abnormal_taste_sensitivity1.35787638
58MP0003828_pulmonary_edema1.35783646
59* MP0000609_abnormal_liver_physiology1.35591931
60MP0001853_heart_inflammation1.34810596
61MP0002429_abnormal_blood_cell1.33224463
62MP0000604_amyloidosis1.30843750
63MP0002095_abnormal_skin_pigmentation1.29581014
64MP0003091_abnormal_cell_migration1.23471837
65MP0001533_abnormal_skeleton_physiology1.20154432
66MP0003453_abnormal_keratinocyte_physiol1.19964731
67MP0000858_altered_metastatic_potential1.19686125
68MP0004019_abnormal_vitamin_homeostasis1.19605887
69MP0000689_abnormal_spleen_morphology1.18706649
70MP0000427_abnormal_hair_cycle1.17966413
71MP0000343_altered_response_to1.15956951
72MP0001851_eye_inflammation1.15340157
73MP0010329_abnormal_lipoprotein_level1.14797862
74MP0005381_digestive/alimentary_phenotyp1.09480587
75MP0005084_abnormal_gallbladder_morpholo1.08324996
76MP0005448_abnormal_energy_balance1.07750549
77MP0003448_altered_tumor_morphology1.05875663
78MP0000627_abnormal_mammary_gland1.03211141
79MP0001873_stomach_inflammation1.03161229
80MP0000249_abnormal_blood_vessel1.02499825
81MP0009764_decreased_sensitivity_to1.01462256
82MP0004858_abnormal_nervous_system0.98491560
83MP0001501_abnormal_sleep_pattern0.98383934
84MP0008007_abnormal_cellular_replicative0.97542137
85MP0004885_abnormal_endolymph0.95745463
86* MP0008469_abnormal_protein_level0.94505683
87MP0003045_fibrosis0.94187753
88MP0003075_altered_response_to0.93927566
89MP0009765_abnormal_xenobiotic_induced0.92624100
90MP0005164_abnormal_response_to0.90867307
91MP0001835_abnormal_antigen_presentation0.90127462
92MP0003186_abnormal_redox_activity0.89610584
93MP0004808_abnormal_hematopoietic_stem0.88826926
94MP0002148_abnormal_hypersensitivity_rea0.88814239
95MP0005165_increased_susceptibility_to0.88659514
96MP0003787_abnormal_imprinting0.87516144
97MP0009840_abnormal_foam_cell0.85647657
98MP0003566_abnormal_cell_adhesion0.84676877
99MP0005390_skeleton_phenotype0.84532293
100MP0001764_abnormal_homeostasis0.83566428
101MP0002166_altered_tumor_susceptibility0.82478162
102MP0000733_abnormal_muscle_development0.82407118
103MP0003252_abnormal_bile_duct0.81925838
104MP0003943_abnormal_hepatobiliary_system0.80791844
105MP0000350_abnormal_cell_proliferation0.80543860
106MP0003329_amyloid_beta_deposits0.78416685
107MP0001529_abnormal_vocalization0.78004708
108MP0009763_increased_sensitivity_to0.77229123
109MP0003705_abnormal_hypodermis_morpholog0.76534298
110MP0004142_abnormal_muscle_tone0.75983832
111* MP0000477_abnormal_intestine_morphology0.74847967
112MP0003690_abnormal_glial_cell0.73136022
113MP0002693_abnormal_pancreas_physiology0.73007111
114MP0004782_abnormal_surfactant_physiolog0.72724357
115MP0005334_abnormal_fat_pad0.72494942
116MP0005464_abnormal_platelet_physiology0.72430387
117MP0001984_abnormal_olfaction0.72169767
118MP0008872_abnormal_physiological_respon0.71497326
119MP0006082_CNS_inflammation0.71297778
120MP0003795_abnormal_bone_structure0.68796926
121MP0001765_abnormal_ion_homeostasis0.68658699
122* MP0000490_abnormal_crypts_of0.67529294
123MP0002086_abnormal_extraembryonic_tissu0.66671985
124MP0005375_adipose_tissue_phenotype0.64675145
125MP0009115_abnormal_fat_cell0.64057038
126MP0005584_abnormal_enzyme/coenzyme_acti0.63908428
127MP0010307_abnormal_tumor_latency0.63517659
128* MP0008873_increased_physiological_sensi0.63308286
129MP0004134_abnormal_chest_morphology0.62941262
130MP0009931_abnormal_skin_appearance0.62311580
131MP0003936_abnormal_reproductive_system0.61675607
132MP0004215_abnormal_myocardial_fiber0.61356806
133MP0005636_abnormal_mineral_homeostasis0.61105511
134MP0001191_abnormal_skin_condition0.60435280
135MP0005365_abnormal_bile_salt0.60333246
136MP0000647_abnormal_sebaceous_gland0.60193633
137MP0003195_calcinosis0.58083458
138MP0000367_abnormal_coat/_hair0.57399927
139MP0004084_abnormal_cardiac_muscle0.53159488
140MP0002938_white_spotting0.50984917
141MP0002332_abnormal_exercise_endurance0.48446475
142MP0001666_abnormal_nutrient_absorption0.47613218
143MP0002006_tumorigenesis0.46579894
144MP0005595_abnormal_vascular_smooth0.45276235
145MP0008775_abnormal_heart_ventricle0.43552798
146MP0002098_abnormal_vibrissa_morphology0.41019980
147MP0010094_abnormal_chromosome_stability0.40871015
148* MP0005319_abnormal_enzyme/_coenzyme0.39108301

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)9.24361107
2Keratoconjunctivitis sicca (HP:0001097)8.08253299
3Keratoconjunctivitis (HP:0001096)7.33532250
4Stomatitis (HP:0010280)6.24262677
5IgM deficiency (HP:0002850)5.67183301
6Arterial thrombosis (HP:0004420)5.37493103
7Abnormality of B cell number (HP:0010975)5.30000581
8B lymphocytopenia (HP:0010976)5.30000581
9Increased IgM level (HP:0003496)5.26891542
10IgA deficiency (HP:0002720)4.69806565
11Pulmonary infiltrates (HP:0002113)4.62486809
12Increased density of long bones (HP:0006392)4.60594384
13Persistence of primary teeth (HP:0006335)4.60472975
14Increased hepatocellular lipid droplets (HP:0006565)4.25481442
15Hemoptysis (HP:0002105)4.21135605
16Recurrent skin infections (HP:0001581)4.13776933
17Vasculitis (HP:0002633)4.05380758
18Gastrointestinal stroma tumor (HP:0100723)4.03971988
19Lipid accumulation in hepatocytes (HP:0006561)3.96695690
20Gangrene (HP:0100758)3.93607624
21Pulmonary embolism (HP:0002204)3.90495302
22Anorexia (HP:0002039)3.82661543
23Periodontitis (HP:0000704)3.74029075
24Encephalitis (HP:0002383)3.50374323
25Recurrent bronchitis (HP:0002837)3.43026215
26Parakeratosis (HP:0001036)3.37570664
27Keratitis (HP:0000491)3.32856636
28Abnormality of proline metabolism (HP:0010907)3.30931743
29Hydroxyprolinuria (HP:0003080)3.30931743
30Skin rash (HP:0000988)3.29555084
31Amniotic constriction ring (HP:0009775)3.23770486
32Abnormality of placental membranes (HP:0011409)3.23770486
33Xerostomia (HP:0000217)3.20601497
34Renal Fanconi syndrome (HP:0001994)3.07503919
35Thrombophlebitis (HP:0004418)3.06264381
36Autoimmune hemolytic anemia (HP:0001890)2.99180977
37Tetraparesis (HP:0002273)2.95762821
38Abnormality of the pericardium (HP:0001697)2.85049695
39T lymphocytopenia (HP:0005403)2.83511006
40Recurrent fungal infections (HP:0002841)2.80034564
41Abnormality of T cells (HP:0002843)2.66789594
42Abnormality of T cell number (HP:0011839)2.64724273
43Exertional dyspnea (HP:0002875)2.64333225
44Abnormality of the endocardium (HP:0004306)2.63607240
45Autoimmune thrombocytopenia (HP:0001973)2.62969578
46Eczematoid dermatitis (HP:0000976)2.61360367
47Vertigo (HP:0002321)2.61054927
48Vertebral compression fractures (HP:0002953)2.59922356
49Acne (HP:0001061)2.59127323
50Metaphyseal cupping (HP:0003021)2.58273578
51Abnormality of the pleura (HP:0002103)2.57664226
52Polyneuropathy (HP:0001271)2.52098870
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.51794684
54Aplasia/Hypoplasia involving the musculature (HP:0001460)2.50573840
55Joint swelling (HP:0001386)2.48994486
56Increased intramyocellular lipid droplets (HP:0012240)2.48458267
57Abnormality of T cell physiology (HP:0011840)2.48108265
58Glomerulopathy (HP:0100820)2.45982922
59Interstitial pulmonary disease (HP:0006530)2.43389969
60Malignant hyperthermia (HP:0002047)2.41858802
61Aseptic necrosis (HP:0010885)2.40842192
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37139644
63Median cleft lip (HP:0000161)2.36855194
64Respiratory difficulties (HP:0002880)2.36792914
65Pruritus (HP:0000989)2.35377922
66Aplasia of the musculature (HP:0100854)2.34688907
67Arthralgia (HP:0002829)2.31149045
68Lower limb hyperreflexia (HP:0002395)2.30319958
69Increased IgE level (HP:0003212)2.22291326
70Abnormality of intracranial pressure (HP:0012640)2.21912467
71Increased intracranial pressure (HP:0002516)2.21912467
72Pancreatitis (HP:0001733)2.20581063
73Long clavicles (HP:0000890)2.19982018
7411 pairs of ribs (HP:0000878)2.19191952
75Abnormality of the fingertips (HP:0001211)2.17905320
76Abnormality of the nasal septum (HP:0000419)2.17253074
77Increased muscle lipid content (HP:0009058)2.16893334
78Postaxial foot polydactyly (HP:0001830)2.14937780
79Paresthesia (HP:0003401)2.11418695
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11233358
81Pancreatic islet-cell hyperplasia (HP:0004510)2.10713024
82Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08838959
83Abnormal albumin level (HP:0012116)2.06451795
84Hypoalbuminemia (HP:0003073)2.06451795
85Loss of speech (HP:0002371)2.04592214
86Hepatosplenomegaly (HP:0001433)2.04292902
87Hypoproteinemia (HP:0003075)2.01470890
88Recurrent sinusitis (HP:0011108)2.00612723
89Meningitis (HP:0001287)2.00607757
90Congenital ichthyosiform erythroderma (HP:0007431)2.00180355
91Optic neuritis (HP:0100653)12.0527916
92Retrobulbar optic neuritis (HP:0100654)12.0527916
93Orchitis (HP:0100796)10.9698721
94Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.99585833
95Vertebral hypoplasia (HP:0008417)1.99585833
96Hypothermia (HP:0002045)1.99565122
97Generalized aminoaciduria (HP:0002909)1.99479445
98Squamous cell carcinoma (HP:0002860)1.99370116
99Emphysema (HP:0002097)1.97150052
100Macroorchidism (HP:0000053)1.96568776
101Mesangial abnormality (HP:0001966)1.95730512
102Hyperphosphaturia (HP:0003109)1.93711620
103Increased neuronal autofluorescent lipopigment (HP:0002074)1.92571814
104Hematuria (HP:0000790)1.92352729
105Cerebral ischemia (HP:0002637)1.90848511
106Bronchitis (HP:0012387)1.90204762
107Abnormality of the renal cortex (HP:0011035)1.89219141
108Rectal prolapse (HP:0002035)1.86093391
109Severe combined immunodeficiency (HP:0004430)1.85885893
110Clumsiness (HP:0002312)1.85755070
111Depressed nasal tip (HP:0000437)1.85754711
112Skull defect (HP:0001362)1.85395469
113Memory impairment (HP:0002354)1.84472886
114Thyroiditis (HP:0100646)1.82518624
115Cutaneous melanoma (HP:0012056)1.82147910
116Tubular atrophy (HP:0000092)1.81975309
117Toxemia of pregnancy (HP:0100603)1.81199147
118Recurrent urinary tract infections (HP:0000010)1.79838289
119Limb hypertonia (HP:0002509)1.77411019
120IgG deficiency (HP:0004315)1.77212679
121Renal cortical cysts (HP:0000803)1.77123482
122Slender build (HP:0001533)1.76486865
123Hypergammaglobulinemia (HP:0010702)1.76122724
124Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74560138
125Increased CSF lactate (HP:0002490)1.74526471
126Abolished electroretinogram (ERG) (HP:0000550)1.73525673
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71998720
128Short 4th metacarpal (HP:0010044)1.71998720
129Chronic diarrhea (HP:0002028)1.71868983
130Nonimmune hydrops fetalis (HP:0001790)1.71010286
131Abnormality of eosinophils (HP:0001879)1.68576875
132Enlarged epiphyses (HP:0010580)1.67676844
133Poikilocytosis (HP:0004447)1.67456186
134Gastrointestinal infarctions (HP:0005244)1.66752420
135Abnormality of renal resorption (HP:0011038)1.66317790
136Abnormality of the fingernails (HP:0001231)1.65295640
137Chondrocalcinosis (HP:0000934)1.62848188
138Recurrent viral infections (HP:0004429)1.60552617
139Stillbirth (HP:0003826)1.60268210
140Pendular nystagmus (HP:0012043)1.59548403
141Mitral stenosis (HP:0001718)1.58995003
142Gonadal dysgenesis (HP:0000133)1.58356159
143Lymphopenia (HP:0001888)1.58037666
144Restrictive lung disease (HP:0002091)1.52536147
145Vertebral arch anomaly (HP:0008438)1.51377304
146Premature loss of primary teeth (HP:0006323)1.51300455
147Rhinitis (HP:0012384)1.51039880
148Abnormality of cells of the lymphoid lineage (HP:0012140)1.46057249
149Combined immunodeficiency (HP:0005387)1.45370174
150Abnormal blistering of the skin (HP:0008066)1.44997748
151Recurrent cutaneous fungal infections (HP:0011370)1.39444354
152Chronic mucocutaneous candidiasis (HP:0002728)1.39444354
153Osteomyelitis (HP:0002754)1.39179439
154Bone pain (HP:0002653)1.34925617
155Cheilitis (HP:0100825)1.32117201
156Acrocyanosis (HP:0001063)1.30888654
157Cranial hyperostosis (HP:0004437)1.30811723
158Leukocytosis (HP:0001974)1.28591908
159Nasal polyposis (HP:0100582)1.28318452
160Subaortic stenosis (HP:0001682)1.27888663
161Abnormality of the left ventricular outflow tract (HP:0011103)1.27888663
162Elevated erythrocyte sedimentation rate (HP:0003565)1.26437339
163Lymphoma (HP:0002665)1.24480150
164Acute myeloid leukemia (HP:0004808)1.22450870
165Abnormality of the common coagulation pathway (HP:0010990)1.21573333
166Back pain (HP:0003418)1.20905810
167Recurrent otitis media (HP:0000403)1.20811226
168Broad palm (HP:0001169)1.20775541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.20551484
2NEK17.11058124
3IRAK37.04500000
4TXK5.71081782
5ACVR1B3.69671677
6MAP2K63.54329163
7EPHB13.48438732
8EPHA33.46438415
9TBK12.54527642
10CLK12.49095733
11TSSK62.36021279
12ERBB42.18203095
13STK392.15703287
14JAK12.15655176
15MAP3K142.04745896
16OXSR12.03985966
17WNK42.00290346
18CDK121.92104473
19FGFR31.83701558
20PHKG21.68483618
21PHKG11.68483618
22BCR1.68396895
23TLK11.65571262
24CSF1R1.64535340
25ITK1.60063379
26FGFR41.59665288
27ZAK1.58914067
28ILK1.47787464
29JAK31.47004974
30MAPKAPK31.45942406
31MYLK1.43804606
32MAP4K11.43312732
33TEC1.42898245
34MAP3K21.37933817
35EEF2K1.37035881
36BMX1.35816309
37ADRBK21.35724063
38TIE11.32642824
39STK38L1.28151197
40PIM11.25214536
41PRKCH1.23481209
42MAPK151.23403333
43FES1.19896386
44MST41.18381428
45BTK1.17773328
46TRIM281.17319964
47DAPK11.13375927
48ERN11.10631950
49IRAK11.06280349
50ALK1.04605030
51STK241.03498402
52CHUK1.03162579
53NLK1.01411042
54PTK60.98830375
55BCKDK0.98708949
56BRD40.98703011
57SIK20.97523959
58PLK30.92694490
59SIK10.91151684
60TRIB30.89044059
61STK30.88767723
62RET0.88511376
63TNK20.87757958
64TTK0.86179778
65VRK10.85706843
66IKBKB0.84880280
67TYK20.84789962
68JAK20.84361981
69SIK30.84217641
70STK100.81750830
71HIPK20.80501808
72WNK10.79640839
73HCK0.74292132
74GRK60.69595264
75ZAP700.68099061
76CSNK1A1L0.67755977
77SYK0.66765440
78IKBKE0.66143001
79MAPKAPK20.65047030
80MAPKAPK50.63882400
81CASK0.63450582
82GSK3A0.63245476
83MAP3K30.62339692
84NME20.61468991
85DMPK0.60516805
86MATK0.57080003
87ATR0.56572477
88CDC42BPA0.55135759
89PAK60.54373436
90RPS6KA60.52980748
91SGK10.52666586
92RPS6KA40.51281631
93MAP2K30.49646122
94NUAK10.48746377
95PKN10.48045480
96MAP3K10.47803622
97MAP3K120.47555837
98RPS6KL10.47205765
99RPS6KC10.47205765
100CDK60.47085125
101SGK30.46319446
102CSK0.44077751
103RPS6KB20.43529887
104RPS6KB10.42397330
105MAP3K70.41980754
106MARK30.41361810
107MAP3K130.40014080
108RIPK10.37816078
109PDGFRB0.37593928
110MAP3K110.37033785
111MELK0.36377136
112PRKCQ0.35286199
113PRKG20.35107681
114FER0.35098351
115PRKCB0.34955722
116ATM0.34913544
117MAP3K50.34578426
118EGFR0.32585630
119PAK40.32493279
120PDPK10.32306432
121CSNK2A10.32168425
122PDK10.31796734
123LCK0.30986822
124CHEK10.30852195
125CAMK2A0.30246011
126CDK40.29829523
127EIF2AK20.29244944
128PRKCA0.29213961
129PNCK0.28993117
130IGF1R0.26953527
131CDK90.26636666
132LRRK20.25586759
133PRKDC0.25110341
134PRPF4B0.24832008
135MTOR0.23889411
136PRKACA0.23339156
137VRK20.23290932
138TGFBR20.22066353
139KIT0.21794468
140PINK10.21198079
141MAPK30.20937177
142ADRBK10.20629959
143PKN20.20235548
144LYN0.20182812
145SGK2230.19757579
146SGK4940.19757579
147STK110.19709780
148RPS6KA50.19058191
149TRPM70.18141364
150PRKG10.18001763
151CSNK1A10.17891042
152CAMK1G0.17687795
153ABL10.16233209
154SGK20.15442377
155MAP3K100.15408340
156MAPK80.15336147
157FYN0.15105056
158MKNK20.13691102
159MAP2K40.12752008
160RPS6KA10.12473869

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002328.11449868
2* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053216.11247647
3Proteasome_Homo sapiens_hsa030503.52231904
4Circadian rhythm_Homo sapiens_hsa047103.37192118
5Osteoclast differentiation_Homo sapiens_hsa043803.16128997
6Allograft rejection_Homo sapiens_hsa053303.04299949
7Protein export_Homo sapiens_hsa030602.93850439
8Autoimmune thyroid disease_Homo sapiens_hsa053202.83902109
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.61270393
10TNF signaling pathway_Homo sapiens_hsa046682.47685134
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.41707173
12* Jak-STAT signaling pathway_Homo sapiens_hsa046302.35395084
13T cell receptor signaling pathway_Homo sapiens_hsa046602.30855170
14Primary immunodeficiency_Homo sapiens_hsa053402.15927655
15Non-homologous end-joining_Homo sapiens_hsa034502.13629160
16Measles_Homo sapiens_hsa051622.00114017
17Prolactin signaling pathway_Homo sapiens_hsa049171.95135828
18Acute myeloid leukemia_Homo sapiens_hsa052211.87767711
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.81646773
20Graft-versus-host disease_Homo sapiens_hsa053321.77807038
21Rheumatoid arthritis_Homo sapiens_hsa053231.65712623
22B cell receptor signaling pathway_Homo sapiens_hsa046621.63175833
23Toxoplasmosis_Homo sapiens_hsa051451.60830044
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.54722148
25* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51690875
26Antigen processing and presentation_Homo sapiens_hsa046121.51070515
27Leishmaniasis_Homo sapiens_hsa051401.51001719
28Type I diabetes mellitus_Homo sapiens_hsa049401.47321787
29Legionellosis_Homo sapiens_hsa051341.46860984
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42233547
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.39493504
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34130834
33Type II diabetes mellitus_Homo sapiens_hsa049301.31659728
34Hepatitis B_Homo sapiens_hsa051611.31637021
35Basal transcription factors_Homo sapiens_hsa030221.30583649
36Chronic myeloid leukemia_Homo sapiens_hsa052201.29926987
37Asthma_Homo sapiens_hsa053101.29637969
38Lysine degradation_Homo sapiens_hsa003101.27838006
39Apoptosis_Homo sapiens_hsa042101.27731467
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27645085
41Influenza A_Homo sapiens_hsa051641.26819101
42Insulin resistance_Homo sapiens_hsa049311.26082218
43Nucleotide excision repair_Homo sapiens_hsa034201.23130919
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21523010
45Homologous recombination_Homo sapiens_hsa034401.21013724
46Selenocompound metabolism_Homo sapiens_hsa004501.15685813
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09920259
48Nitrogen metabolism_Homo sapiens_hsa009101.05646725
49MAPK signaling pathway_Homo sapiens_hsa040101.02507402
50Chemokine signaling pathway_Homo sapiens_hsa040621.02242107
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01067883
52RNA degradation_Homo sapiens_hsa030180.98047904
53Shigellosis_Homo sapiens_hsa051310.95159119
54Endocytosis_Homo sapiens_hsa041440.93752257
55Pancreatic cancer_Homo sapiens_hsa052120.93040168
56Fat digestion and absorption_Homo sapiens_hsa049750.92412018
57Epstein-Barr virus infection_Homo sapiens_hsa051690.90359648
58HTLV-I infection_Homo sapiens_hsa051660.89933543
59VEGF signaling pathway_Homo sapiens_hsa043700.89520422
60Dorso-ventral axis formation_Homo sapiens_hsa043200.89193261
61Estrogen signaling pathway_Homo sapiens_hsa049150.88900266
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87614975
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87059880
64Cocaine addiction_Homo sapiens_hsa050300.86322017
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85003781
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83714091
67Small cell lung cancer_Homo sapiens_hsa052220.83257155
68Renal cell carcinoma_Homo sapiens_hsa052110.83222635
69Regulation of autophagy_Homo sapiens_hsa041400.82658810
70Phototransduction_Homo sapiens_hsa047440.81258140
71Hepatitis C_Homo sapiens_hsa051600.81186099
72Hematopoietic cell lineage_Homo sapiens_hsa046400.79528513
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79310640
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79157413
75Herpes simplex infection_Homo sapiens_hsa051680.79033726
76Retinol metabolism_Homo sapiens_hsa008300.78470645
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78345817
78ErbB signaling pathway_Homo sapiens_hsa040120.77272863
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74651333
80FoxO signaling pathway_Homo sapiens_hsa040680.73616929
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.72914808
82Malaria_Homo sapiens_hsa051440.72556912
83Viral carcinogenesis_Homo sapiens_hsa052030.71142533
84Platelet activation_Homo sapiens_hsa046110.68584125
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68143264
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67755638
87African trypanosomiasis_Homo sapiens_hsa051430.67407860
88Oxidative phosphorylation_Homo sapiens_hsa001900.66035057
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65777889
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65588999
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65027313
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64005643
93Propanoate metabolism_Homo sapiens_hsa006400.63772715
94Salmonella infection_Homo sapiens_hsa051320.62872712
95Arginine and proline metabolism_Homo sapiens_hsa003300.62600988
96Tuberculosis_Homo sapiens_hsa051520.62294041
97mTOR signaling pathway_Homo sapiens_hsa041500.61670709
98MicroRNAs in cancer_Homo sapiens_hsa052060.60872440
99HIF-1 signaling pathway_Homo sapiens_hsa040660.60586924
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59425879
101Prion diseases_Homo sapiens_hsa050200.59233978
102Glycerolipid metabolism_Homo sapiens_hsa005610.57292336
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56084711
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56074532
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55337607
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54810943
107Parkinsons disease_Homo sapiens_hsa050120.52882137
108Long-term potentiation_Homo sapiens_hsa047200.52583233
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52157686
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51615703
111Prostate cancer_Homo sapiens_hsa052150.50756352
112Viral myocarditis_Homo sapiens_hsa054160.50465660
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.49424110
114Ether lipid metabolism_Homo sapiens_hsa005650.48975770
115Insulin signaling pathway_Homo sapiens_hsa049100.48816154
116Proteoglycans in cancer_Homo sapiens_hsa052050.48573301
117Colorectal cancer_Homo sapiens_hsa052100.47845899
118Amoebiasis_Homo sapiens_hsa051460.46227500
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.45467428
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44859343
121GnRH signaling pathway_Homo sapiens_hsa049120.44820623
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43118979
123Peroxisome_Homo sapiens_hsa041460.42608542
124Linoleic acid metabolism_Homo sapiens_hsa005910.42333331
125Non-small cell lung cancer_Homo sapiens_hsa052230.41880875
126Focal adhesion_Homo sapiens_hsa045100.40373331
127Renin secretion_Homo sapiens_hsa049240.39705056
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39525033
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.39354501
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38966718
131Purine metabolism_Homo sapiens_hsa002300.38934190
132Pathways in cancer_Homo sapiens_hsa052000.38434183
133Arginine biosynthesis_Homo sapiens_hsa002200.37976671
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37511599
135Glioma_Homo sapiens_hsa052140.37435984
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36578941
137Amphetamine addiction_Homo sapiens_hsa050310.36225652
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36033806
139Mismatch repair_Homo sapiens_hsa034300.35600835
140cAMP signaling pathway_Homo sapiens_hsa040240.35389530
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35385030
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35262018
143Fanconi anemia pathway_Homo sapiens_hsa034600.33769132
144Sulfur relay system_Homo sapiens_hsa041220.32245612
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28894409
146Chemical carcinogenesis_Homo sapiens_hsa052040.28287107
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23590013
148Tryptophan metabolism_Homo sapiens_hsa003800.20007926
149Pertussis_Homo sapiens_hsa051330.18108360
150RNA polymerase_Homo sapiens_hsa030200.16147029
151Steroid biosynthesis_Homo sapiens_hsa001000.15256421
152Starch and sucrose metabolism_Homo sapiens_hsa005000.11655849
153Vitamin digestion and absorption_Homo sapiens_hsa049770.11630995
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11626073
155RNA transport_Homo sapiens_hsa030130.10506288
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.09830643
157Olfactory transduction_Homo sapiens_hsa047400.09079059
158Huntingtons disease_Homo sapiens_hsa050160.08548702
159Collecting duct acid secretion_Homo sapiens_hsa049660.08111658
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05204812
161Metabolic pathways_Homo sapiens_hsa011000.05109525
162Systemic lupus erythematosus_Homo sapiens_hsa053220.04467645
163Calcium signaling pathway_Homo sapiens_hsa040200.04295792
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.03526952
165Alzheimers disease_Homo sapiens_hsa050100.03088687
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.02658441
167Glycosaminoglycan degradation_Homo sapiens_hsa005310.02616050

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