IL23A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1natural killer cell activation involved in immune response (GO:0002323)7.38780132
2* positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)7.17528278
3regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)7.04109681
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)7.04109681
5* regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)6.47277513
6regulation of T-helper 1 cell differentiation (GO:0045625)6.38147684
7* positive regulation of T-helper cell differentiation (GO:0045624)6.19984648
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.17910582
9regulation of chronic inflammatory response (GO:0002676)5.96664123
10* regulation of activation of Janus kinase activity (GO:0010533)5.54421091
11* positive regulation of T-helper 1 type immune response (GO:0002827)5.44653385
12cellular response to exogenous dsRNA (GO:0071360)5.29116253
13regulation of fever generation (GO:0031620)4.84151347
14response to protozoan (GO:0001562)4.78167741
15regulation of dendritic cell antigen processing and presentation (GO:0002604)4.75747593
16positive regulation of heat generation (GO:0031652)4.67698396
17* regulation of T-helper cell differentiation (GO:0045622)4.64007600
18* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.61324690
19regulation of response to tumor cell (GO:0002834)4.59400724
20positive regulation of response to tumor cell (GO:0002836)4.59400724
21positive regulation of immune response to tumor cell (GO:0002839)4.59400724
22regulation of immune response to tumor cell (GO:0002837)4.59400724
23negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.58372933
24response to peptidoglycan (GO:0032494)4.57452798
25* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.43531621
26* regulation of memory T cell differentiation (GO:0043380)4.34725486
27negative regulation of interleukin-17 production (GO:0032700)4.33791476
28positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.32889552
29adhesion of symbiont to host cell (GO:0044650)4.30691222
30virion attachment to host cell (GO:0019062)4.30691222
31regulation of MHC class I biosynthetic process (GO:0045343)4.25213458
32T-helper 1 type immune response (GO:0042088)4.22449726
33positive regulation of natural killer cell differentiation (GO:0032825)4.15944444
34* regulation of T-helper 1 type immune response (GO:0002825)4.15645042
35regulation of interleukin-2 biosynthetic process (GO:0045076)4.13409994
36cellular response to interferon-beta (GO:0035458)4.13285162
37* positive regulation of interleukin-17 production (GO:0032740)4.12045063
38negative regulation of interleukin-12 production (GO:0032695)4.07796808
39* positive regulation of natural killer cell activation (GO:0032816)3.95833858
40negative regulation of type 2 immune response (GO:0002829)3.93726098
41regulation of interferon-gamma biosynthetic process (GO:0045072)3.90316301
42fatty acid elongation (GO:0030497)3.87362587
43negative regulation of T cell mediated immunity (GO:0002710)3.87114222
44* positive regulation of NF-kappaB import into nucleus (GO:0042346)3.84374336
45T-helper cell differentiation (GO:0042093)3.83680717
46CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.83680717
47central nervous system myelination (GO:0022010)3.83376463
48axon ensheathment in central nervous system (GO:0032291)3.83376463
49negative regulation of growth of symbiont in host (GO:0044130)3.83206684
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.83206684
51modulation of growth of symbiont involved in interaction with host (GO:0044144)3.83206684
52regulation of growth of symbiont in host (GO:0044126)3.83206684
53regulation of T cell cytokine production (GO:0002724)3.79352361
54positive regulation of gamma-delta T cell activation (GO:0046645)3.74487416
55regulation of heat generation (GO:0031650)3.73668100
56* positive regulation of alpha-beta T cell proliferation (GO:0046641)3.72679898
57positive regulation of interleukin-2 production (GO:0032743)3.70964593
58regulation of inflammatory response to antigenic stimulus (GO:0002861)3.70018954
59response to interferon-beta (GO:0035456)3.69859869
60Rap protein signal transduction (GO:0032486)3.68443636
61leukocyte aggregation (GO:0070486)3.67995060
62* positive regulation of interleukin-12 production (GO:0032735)3.67873077
63regulation of cytokine secretion involved in immune response (GO:0002739)3.64747285
64regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.63892671
65regulation of vitamin D biosynthetic process (GO:0060556)3.58730146
66* regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.58583242
67response to hepatocyte growth factor (GO:0035728)3.58488939
68cellular response to hepatocyte growth factor stimulus (GO:0035729)3.58488939
69positive regulation of actin filament depolymerization (GO:0030836)3.56988517
70* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.56829154
71* regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.54140847
72regulation of interferon-alpha production (GO:0032647)3.51662183
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.47378964
74T cell differentiation involved in immune response (GO:0002292)3.46788833
75alpha-beta T cell differentiation involved in immune response (GO:0002293)3.46788833
76alpha-beta T cell activation involved in immune response (GO:0002287)3.46788833
77positive regulation of isotype switching (GO:0045830)3.46366922
78* positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.42025562
79* regulation of interleukin-12 production (GO:0032655)3.41369440
80response to muramyl dipeptide (GO:0032495)3.39559621
81* positive regulation of activated T cell proliferation (GO:0042104)3.39515714
82positive regulation of monocyte chemotaxis (GO:0090026)3.38987222
83regulation of podosome assembly (GO:0071801)3.36594348
84lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34001128
85* regulation of interleukin-17 production (GO:0032660)3.33475776
86adhesion of symbiont to host (GO:0044406)3.32391663
87branching involved in labyrinthine layer morphogenesis (GO:0060670)3.32031864
88* regulation of natural killer cell activation (GO:0032814)3.31542702
89positive regulation of antigen processing and presentation (GO:0002579)3.30658681
90regulation of lymphocyte chemotaxis (GO:1901623)3.29452782
91regulation of isotype switching to IgG isotypes (GO:0048302)3.28899014
92cellular response to type I interferon (GO:0071357)3.28536041
93type I interferon signaling pathway (GO:0060337)3.28536041
94regulation of type 2 immune response (GO:0002828)3.28476630
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.27706236
96regulation of natural killer cell mediated immunity (GO:0002715)3.27706236
97positive regulation of chemokine biosynthetic process (GO:0045080)3.26498252
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24512268
99axon ensheathment (GO:0008366)3.23885154
100ensheathment of neurons (GO:0007272)3.23885154
101myelination (GO:0042552)3.23635112
102response to type I interferon (GO:0034340)3.22837721
103* positive regulation of defense response to virus by host (GO:0002230)3.22324128
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21562454
105positive regulation of lymphocyte migration (GO:2000403)3.21378721
106regulation of chemokine biosynthetic process (GO:0045073)3.18213785
107negative regulation of amino acid transport (GO:0051956)3.16049839
108regulation of vitamin metabolic process (GO:0030656)3.15838793
109regulation of isotype switching (GO:0045191)3.15312834
110regulation of regulatory T cell differentiation (GO:0045589)3.13692534
111regulation of membrane protein ectodomain proteolysis (GO:0051043)3.12319936
112* positive regulation of interferon-gamma production (GO:0032729)3.12076987
113positive regulation of type 2 immune response (GO:0002830)3.11872335
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.09123799
115cholesterol biosynthetic process (GO:0006695)3.08548175
116regulation of interleukin-12 biosynthetic process (GO:0045075)3.08287768
117defense response to protozoan (GO:0042832)3.07930967
118* negative regulation of interleukin-10 production (GO:0032693)3.07102452
119positive regulation of DNA recombination (GO:0045911)3.05766957
120* regulation of defense response to virus by host (GO:0050691)3.03377517
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.99825906
122positive regulation of acute inflammatory response (GO:0002675)2.99672940
123negative regulation of nitric oxide biosynthetic process (GO:0045019)2.99611688
124* regulation of alpha-beta T cell proliferation (GO:0046640)2.99181136
125detection of other organism (GO:0098543)2.98565437
126negative regulation by host of viral transcription (GO:0043922)2.96983737
127regulation of immunoglobulin secretion (GO:0051023)2.96844311
128positive regulation of B cell mediated immunity (GO:0002714)2.94852702
129positive regulation of immunoglobulin mediated immune response (GO:0002891)2.94852702
130NIK/NF-kappaB signaling (GO:0038061)2.91542381
131negative regulation of cytokine production involved in immune response (GO:0002719)2.91104467
132sexual reproduction (GO:0019953)2.90307132
133* regulation of T cell mediated immunity (GO:0002709)2.83054242
134myeloid dendritic cell differentiation (GO:0043011)2.82975696
135positive regulation of natural killer cell mediated immunity (GO:0002717)2.82749001
136positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.82749001
137regulation of antigen processing and presentation (GO:0002577)2.82489662
138positive regulation of cytokine biosynthetic process (GO:0042108)2.79488079
139eosinophil migration (GO:0072677)2.77836836
140* regulation of NF-kappaB import into nucleus (GO:0042345)2.75546904
141lymphocyte chemotaxis (GO:0048247)2.73784592
142negative regulation of viral genome replication (GO:0045071)2.72645451
143regulation of heterotypic cell-cell adhesion (GO:0034114)2.72135397
144superoxide anion generation (GO:0042554)2.71651272
145T cell activation involved in immune response (GO:0002286)2.67330763
146* positive regulation of interleukin-10 production (GO:0032733)2.65291810
147positive regulation of interferon-alpha production (GO:0032727)2.64792616
148negative regulation of neurotransmitter secretion (GO:0046929)2.61855902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.71647303
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19747358
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.00793719
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.74796097
5* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.37546842
6GATA1_22025678_ChIP-Seq_K562_Human3.30399109
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.87594681
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.61216342
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56539834
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48839766
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47556869
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.46160166
13MYB_26560356_Chip-Seq_TH2_Human2.31702764
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.19507219
15MAF_26560356_Chip-Seq_TH1_Human2.17891371
16VDR_21846776_ChIP-Seq_THP-1_Human2.11870703
17MYC_22102868_ChIP-Seq_BL_Human2.11486803
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10894913
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.04109683
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96201760
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95025273
22GBX2_23144817_ChIP-Seq_PC3_Human1.94271149
23SPI1_23547873_ChIP-Seq_NB4_Human1.93129897
24MYB_26560356_Chip-Seq_TH1_Human1.86248154
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85629494
26VDR_24763502_ChIP-Seq_THP-1_Human1.84394206
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83787469
28VDR_24787735_ChIP-Seq_THP-1_Human1.83467104
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81280120
30SCL_19346495_ChIP-Seq_HPC-7_Human1.79327611
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75717449
32MAF_26560356_Chip-Seq_TH2_Human1.74915022
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73527425
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70910579
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70662045
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70546817
37SPI1_23127762_ChIP-Seq_K562_Human1.70398845
38UTX_26944678_Chip-Seq_JUKART_Human1.69453118
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68659534
40ER_23166858_ChIP-Seq_MCF-7_Human1.67239224
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66253206
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.60552352
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60096141
44VDR_22108803_ChIP-Seq_LS180_Human1.59884475
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57302014
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57038668
47GATA3_26560356_Chip-Seq_TH2_Human1.56809274
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.56295960
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.54098517
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.50960434
51GATA3_27048872_Chip-Seq_THYMUS_Human1.48181432
52NCOR1_26117541_ChIP-Seq_K562_Human1.47168699
53GATA1_19941826_ChIP-Seq_K562_Human1.42292984
54FUS_26573619_Chip-Seq_HEK293_Human1.41555569
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41537444
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40928479
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40120767
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34868764
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34008754
60TAF15_26573619_Chip-Seq_HEK293_Human1.33773242
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33305542
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32850185
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29920110
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29785515
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.29053930
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28983048
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28289561
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28289561
69* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28155325
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27454027
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26779234
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26266258
73* SOX2_20726797_ChIP-Seq_SW620_Human1.26177877
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.25622405
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24949297
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24613585
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22279694
78TCF7_22412390_ChIP-Seq_EML_Mouse1.20072653
79* PU_27001747_Chip-Seq_BMDM_Mouse1.19956476
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.19663594
81RUNX_20019798_ChIP-Seq_JUKART_Human1.18983514
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17535992
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17535992
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17535992
85IGF1R_20145208_ChIP-Seq_DFB_Human1.16128663
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15510725
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15223420
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14786637
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13468489
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13069837
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12829875
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.12344522
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11716774
94* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11331852
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11260067
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11047620
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11028147
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.09952947
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09455236
100DROSHA_22980978_ChIP-Seq_HELA_Human1.09169146
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.08803040
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08772347
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07818101
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07283519
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07242600
106KDM2B_26808549_Chip-Seq_DND41_Human1.06597817
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06169589
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05642274
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05544294
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.05019488
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.03886590
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03877904
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02828047
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02717951
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01294242
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01095786
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.00470920
118CJUN_26792858_Chip-Seq_BT549_Human1.00456753
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00271213
120GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00089879
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99968064
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99925549
123MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97827422
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97121444
125GATA2_19941826_ChIP-Seq_K562_Human0.96983095
126TP53_18474530_ChIP-ChIP_U2OS_Human0.96929199
127SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96298777
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95366632
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94825041
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94730019
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94614296
132P300_19829295_ChIP-Seq_ESCs_Human0.94120018
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93897115
134TFEB_21752829_ChIP-Seq_HELA_Human0.93829976
135P300_18555785_Chip-Seq_ESCs_Mouse0.91598825
136* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91552505
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.90476320
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90275785
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90199782
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90124109
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89119786
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88996623
143PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88737279
144* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88641287
145TAL1_26923725_Chip-Seq_HPCs_Mouse0.88297394
146P53_22387025_ChIP-Seq_ESCs_Mouse0.88250189
147SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88191684
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87288008
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87234518
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86332625
151HTT_18923047_ChIP-ChIP_STHdh_Human0.86326253
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86270055
153LXR_22292898_ChIP-Seq_THP-1_Human0.86227252
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85984923
155CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85683256
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85649079
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.84869479
158SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84143573
159SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84019861
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.84008786
161SMRT_27268052_Chip-Seq_Bcells_Human0.83934883
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.83813209
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83537614
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83464847
165BCL6_27268052_Chip-Seq_Bcells_Human0.83463359
166STAT1_20625510_ChIP-Seq_HELA_Human0.82959709
167LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82655120
168CDX2_22108803_ChIP-Seq_LS180_Human0.81263648
169VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81227799
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80673372
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80673372
172SOX2_18555785_Chip-Seq_ESCs_Mouse0.79719305
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79626965
174RNF2_18974828_ChIP-Seq_MESCs_Mouse0.79318646
175EZH2_18974828_ChIP-Seq_MESCs_Mouse0.79318646
176BCOR_27268052_Chip-Seq_Bcells_Human0.77209920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation6.26939634
2* MP0009785_altered_susceptibility_to4.07851656
3MP0002148_abnormal_hypersensitivity_rea3.79567708
4MP0000920_abnormal_myelination3.70989940
5MP0003690_abnormal_glial_cell3.61651352
6MP0002254_reproductive_system_inflammat3.53432677
7MP0003300_gastrointestinal_ulcer3.52721554
8MP0003724_increased_susceptibility_to3.06290310
9MP0000685_abnormal_immune_system2.78461874
10* MP0005000_abnormal_immune_tolerance2.73305707
11MP0001348_abnormal_lacrimal_gland2.71843557
12MP0001346_abnormal_lacrimal_gland2.67053310
13MP0005623_abnormal_meninges_morphology2.64694124
14* MP0005025_abnormal_response_to2.51725262
15MP0001835_abnormal_antigen_presentation2.49450914
16MP0005310_abnormal_salivary_gland2.33601871
17* MP0002419_abnormal_innate_immunity2.28750889
18MP0005671_abnormal_response_to2.26438931
19MP0009764_decreased_sensitivity_to2.17422683
20MP0003453_abnormal_keratinocyte_physiol2.12554524
21MP0003763_abnormal_thymus_physiology1.94576683
22MP0008057_abnormal_DNA_replication1.91792131
23MP0003880_abnormal_central_pattern1.86962967
24MP0001790_abnormal_immune_system1.80951347
25MP0005387_immune_system_phenotype1.80951347
26MP0009333_abnormal_splenocyte_physiolog1.80689840
27* MP0002723_abnormal_immune_serum1.80484174
28MP0004510_myositis1.79676194
29MP0005451_abnormal_body_composition1.77953500
30MP0002006_tumorigenesis1.75040024
31MP0004947_skin_inflammation1.74978056
32MP0003436_decreased_susceptibility_to1.73588366
33MP0002332_abnormal_exercise_endurance1.64199590
34MP0000383_abnormal_hair_follicle1.63751829
35MP0003950_abnormal_plasma_membrane1.61650812
36* MP0002452_abnormal_antigen_presenting1.60714488
37MP0003303_peritoneal_inflammation1.59069444
38MP0003448_altered_tumor_morphology1.56244354
39MP0003329_amyloid_beta_deposits1.52669663
40* MP0001800_abnormal_humoral_immune1.49722946
41MP0010678_abnormal_skin_adnexa1.46411636
42MP0009840_abnormal_foam_cell1.41776396
43MP0009278_abnormal_bone_marrow1.41439745
44MP0000604_amyloidosis1.40961418
45MP0005397_hematopoietic_system_phenotyp1.40178358
46MP0001545_abnormal_hematopoietic_system1.40178358
47MP0010352_gastrointestinal_tract_polyps1.37355462
48MP0002876_abnormal_thyroid_physiology1.36540672
49* MP0001819_abnormal_immune_cell1.36297446
50MP0004270_analgesia1.36064612
51MP0003195_calcinosis1.35142622
52* MP0002420_abnormal_adaptive_immunity1.33517467
53MP0008004_abnormal_stomach_pH1.32049844
54* MP0001845_abnormal_inflammatory_respons1.30573891
55MP0003075_altered_response_to1.29119300
56* MP0008469_abnormal_protein_level1.28983664
57MP0002138_abnormal_hepatobiliary_system1.27958213
58* MP0009765_abnormal_xenobiotic_induced1.24558136
59MP0002722_abnormal_immune_system1.24354311
60MP0001485_abnormal_pinna_reflex1.23778450
61MP0002139_abnormal_hepatobiliary_system1.23582471
62MP0000689_abnormal_spleen_morphology1.23531792
63MP0003806_abnormal_nucleotide_metabolis1.20805458
64MP0001851_eye_inflammation1.19533404
65MP0001501_abnormal_sleep_pattern1.18931176
66MP0003634_abnormal_glial_cell1.16753653
67MP0005167_abnormal_blood-brain_barrier1.11269719
68MP0001533_abnormal_skeleton_physiology1.11010158
69MP0004742_abnormal_vestibular_system1.10259618
70MP0001905_abnormal_dopamine_level1.09691246
71MP0002405_respiratory_system_inflammati1.05931502
72MP0005164_abnormal_response_to1.05696987
73MP0000858_altered_metastatic_potential1.03375616
74MP0001663_abnormal_digestive_system1.01386260
75MP0002277_abnormal_respiratory_mucosa0.98699223
76MP0003632_abnormal_nervous_system0.95106626
77MP0005464_abnormal_platelet_physiology0.94137843
78MP0000703_abnormal_thymus_morphology0.91945768
79MP0003172_abnormal_lysosome_physiology0.90932996
80MP0005166_decreased_susceptibility_to0.90530211
81MP0000465_gastrointestinal_hemorrhage0.90388946
82MP0002295_abnormal_pulmonary_circulatio0.90044655
83MP0001919_abnormal_reproductive_system0.88764195
84MP0003646_muscle_fatigue0.88677181
85* MP0000716_abnormal_immune_system0.88286062
86* MP0010155_abnormal_intestine_physiology0.87113081
87MP0004885_abnormal_endolymph0.83815356
88MP0003828_pulmonary_edema0.83672493
89MP0005058_abnormal_lysosome_morphology0.81215584
90MP0000613_abnormal_salivary_gland0.80012157
91MP0002734_abnormal_mechanical_nocicepti0.77585688
92MP0005645_abnormal_hypothalamus_physiol0.72067815
93MP0003866_abnormal_defecation0.72017580
94MP0000462_abnormal_digestive_system0.71511601
95MP0005390_skeleton_phenotype0.70241669
96MP0002933_joint_inflammation0.69292051
97MP0000343_altered_response_to0.69195294
98MP0010307_abnormal_tumor_latency0.69017408
99MP0008874_decreased_physiological_sensi0.68296695
100MP0000678_abnormal_parathyroid_gland0.67220781
101MP0001440_abnormal_grooming_behavior0.67105191
102MP0004808_abnormal_hematopoietic_stem0.64865755
103MP0000470_abnormal_stomach_morphology0.64435187
104MP0008875_abnormal_xenobiotic_pharmacok0.64019946
105MP0005666_abnormal_adipose_tissue0.63515346
106MP0005023_abnormal_wound_healing0.63441330
107MP0002733_abnormal_thermal_nociception0.62366166
108MP0000490_abnormal_crypts_of0.62121134
109MP0001873_stomach_inflammation0.61739410
110* MP0009763_increased_sensitivity_to0.61658596
111MP0005171_absent_coat_pigmentation0.60955810
112MP0005647_abnormal_sex_gland0.60217330
113MP0003091_abnormal_cell_migration0.59130143
114MP0001853_heart_inflammation0.58762177
115MP0001727_abnormal_embryo_implantation0.58423045
116MP0001542_abnormal_bone_strength0.58232433
117MP0003045_fibrosis0.57965868
118MP0000778_abnormal_nervous_system0.57807191
119MP0005266_abnormal_metabolism0.57651458
120MP0000249_abnormal_blood_vessel0.57474953
121MP0005535_abnormal_body_temperature0.57432274
122* MP0002429_abnormal_blood_cell0.57312856
123* MP0002398_abnormal_bone_marrow0.57194588
124* MP0002019_abnormal_tumor_incidence0.56600209
125MP0002272_abnormal_nervous_system0.56571810
126MP0001881_abnormal_mammary_gland0.55975400
127MP0002693_abnormal_pancreas_physiology0.55960819
128MP0000609_abnormal_liver_physiology0.55632698
129MP0003656_abnormal_erythrocyte_physiolo0.54000293
130MP0005381_digestive/alimentary_phenotyp0.53956957
131MP0003959_abnormal_lean_body0.53896665
132MP0002998_abnormal_bone_remodeling0.53732409
133MP0005319_abnormal_enzyme/_coenzyme0.53513063

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.59747328
2Stomatitis (HP:0010280)5.01625638
3Retrobulbar optic neuritis (HP:0100654)4.79965648
4Optic neuritis (HP:0100653)4.79965648
5Sensory axonal neuropathy (HP:0003390)4.76514110
6Eczematoid dermatitis (HP:0000976)4.70461757
7Gastrointestinal infarctions (HP:0005244)4.50976822
8Recurrent abscess formation (HP:0002722)4.30870394
9T lymphocytopenia (HP:0005403)4.24549097
10Abnormality of glycolipid metabolism (HP:0010969)4.14144829
11Abnormality of liposaccharide metabolism (HP:0010968)4.14144829
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.14144829
13Neurofibrillary tangles (HP:0002185)4.11723966
14Recurrent bacterial skin infections (HP:0005406)4.04375533
15Orchitis (HP:0100796)4.02769973
16Keratoconjunctivitis (HP:0001096)3.97025286
17Abnormality of T cell number (HP:0011839)3.94711158
18Recurrent skin infections (HP:0001581)3.90785409
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.88177191
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.88177191
21Thick nail (HP:0001805)3.87259699
22Abnormality of macrophages (HP:0004311)3.82459967
23Interstitial pulmonary disease (HP:0006530)3.79954112
24Autoimmune hemolytic anemia (HP:0001890)3.66579856
25IgG deficiency (HP:0004315)3.62453254
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60574202
27Elevated erythrocyte sedimentation rate (HP:0003565)3.57093456
28Recurrent gram-negative bacterial infections (HP:0005420)3.55331177
29Gangrene (HP:0100758)3.52071897
30Prolonged neonatal jaundice (HP:0006579)3.50041538
31Myositis (HP:0100614)3.49624565
32Vasculitis (HP:0002633)3.43393508
33Vacuolated lymphocytes (HP:0001922)3.40899234
34Autoimmune thrombocytopenia (HP:0001973)3.27644086
35Fused cervical vertebrae (HP:0002949)3.27267799
36Akinesia (HP:0002304)3.22044743
37Mediastinal lymphadenopathy (HP:0100721)3.18789244
38Recurrent cutaneous fungal infections (HP:0011370)3.13235596
39Chronic mucocutaneous candidiasis (HP:0002728)3.13235596
40Recurrent viral infections (HP:0004429)3.12058722
41Amaurosis fugax (HP:0100576)3.09223072
42Xerostomia (HP:0000217)3.04703332
43Hypertensive crisis (HP:0100735)3.02594729
44Congenital ichthyosiform erythroderma (HP:0007431)2.95491557
45IgA deficiency (HP:0002720)2.91349836
46Increased IgM level (HP:0003496)2.90051123
47Combined immunodeficiency (HP:0005387)2.86799736
48Increased serum ferritin (HP:0003281)2.86256622
49Abnormality of T cells (HP:0002843)2.84635962
50Stenosis of the external auditory canal (HP:0000402)2.81597349
51Purpura (HP:0000979)2.77364676
52Abnormality of the corticospinal tract (HP:0002492)2.76838774
53Keratoconjunctivitis sicca (HP:0001097)2.76628557
54Cerebral hemorrhage (HP:0001342)2.71772794
55Dysostosis multiplex (HP:0000943)2.71347158
56Cerebral inclusion bodies (HP:0100314)2.67630559
57Meningitis (HP:0001287)2.64715241
58Conical tooth (HP:0000698)2.63891677
59Increased cerebral lipofuscin (HP:0011813)2.59809746
60Chronic diarrhea (HP:0002028)2.59481119
61Colitis (HP:0002583)2.59442527
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.56906194
63Hemorrhage of the eye (HP:0011885)2.54623669
64Severe combined immunodeficiency (HP:0004430)2.53767902
65Obstructive lung disease (HP:0006536)2.52955149
66Chronic obstructive pulmonary disease (HP:0006510)2.52955149
67Abnormality of B cell number (HP:0010975)2.52596147
68Loss of speech (HP:0002371)2.52205910
69Hemoptysis (HP:0002105)2.51797296
70B lymphocytopenia (HP:0010976)2.51001996
71Nausea (HP:0002018)2.48843702
72Thin bony cortex (HP:0002753)2.47981750
73Inflammation of the large intestine (HP:0002037)2.47850565
74Hepatosplenomegaly (HP:0001433)2.47796846
75Joint swelling (HP:0001386)2.46812574
76Recurrent fungal infections (HP:0002841)2.44488571
77Chest pain (HP:0100749)2.43131668
78Gingivitis (HP:0000230)2.40964000
79Asplenia (HP:0001746)2.40731078
80Gastrointestinal stroma tumor (HP:0100723)2.40572175
81Onion bulb formation (HP:0003383)2.40360907
82Spastic paraparesis (HP:0002313)2.38987201
83Abnormality of the endocardium (HP:0004306)2.37484147
84Erythroderma (HP:0001019)2.37136099
85Nuclear cataract (HP:0100018)2.36748909
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36662475
87Hypergammaglobulinemia (HP:0010702)2.35983396
88Flat occiput (HP:0005469)2.35798727
89Alacrima (HP:0000522)2.33791053
90Small epiphyses (HP:0010585)2.32186307
91Gastrointestinal inflammation (HP:0004386)2.32110720
92Polyneuropathy (HP:0001271)2.31032720
93Arterial thrombosis (HP:0004420)2.30844873
94Supranuclear gaze palsy (HP:0000605)2.30343212
95Double outlet right ventricle (HP:0001719)2.30183822
96Congenital malformation of the right heart (HP:0011723)2.30183822
97Generalized aminoaciduria (HP:0002909)2.28810591
98Absent hand (HP:0004050)2.28373842
99Abnormal delayed hypersensitivity skin test (HP:0002963)2.27041928
100Cerebral hypomyelination (HP:0006808)2.24787853
101Disinhibition (HP:0000734)2.23547804
102Decreased subcutaneous fat (HP:0001002)2.22001800
103Granulocytopenia (HP:0001913)2.20530014
104Metaphyseal irregularity (HP:0003025)2.18941545
105Pulmonary infiltrates (HP:0002113)2.17991491
106Peripheral hypomyelination (HP:0007182)2.17608237
107Recurrent pneumonia (HP:0006532)2.13404361
108Abnormality of the pleura (HP:0002103)2.13061242
109Slow saccadic eye movements (HP:0000514)2.12353353
110Enlarged epiphyses (HP:0010580)2.12133075
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.11706701
112Abnormality of iron homeostasis (HP:0011031)2.11073476
113Glomerulopathy (HP:0100820)2.08695893
114Abnormality of calcium-phosphate metabolism (HP:0100530)2.07646018
115Hematochezia (HP:0002573)2.07405590
116Cellulitis (HP:0100658)2.06583164
117Lymphopenia (HP:0001888)2.06312583
118Systemic lupus erythematosus (HP:0002725)2.05635813
119Increased IgE level (HP:0003212)2.05505191
120Acne (HP:0001061)2.03372760
121Petechiae (HP:0000967)2.02839910
122Delayed epiphyseal ossification (HP:0002663)2.01962284
123Abnormality of eosinophils (HP:0001879)2.00126322
124Abnormality of the pericardium (HP:0001697)1.98231686
125Respiratory distress (HP:0002098)1.98224092
126Increased circulating renin level (HP:0000848)1.97141222
127Urticaria (HP:0001025)1.96612184
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.94945644
129Cupped ear (HP:0000378)1.94926682
130Neoplasm of head and neck (HP:0012288)1.94202012
131Esophageal neoplasm (HP:0100751)1.94202012
132Recurrent bronchitis (HP:0002837)1.94060954
133Paraparesis (HP:0002385)1.92262851
134Leukocytosis (HP:0001974)1.91830714
135Anorexia (HP:0002039)1.91540708
136Oral leukoplakia (HP:0002745)1.91333748
137Diminished movement (HP:0002374)1.90326605
138Premature skin wrinkling (HP:0100678)1.89457030
139Chronic otitis media (HP:0000389)1.89089635
140Pustule (HP:0200039)1.87905011
141Hyperphosphatemia (HP:0002905)1.87577796
142Spastic gait (HP:0002064)1.84301110
143Depressed nasal tip (HP:0000437)1.82856339
144Encephalitis (HP:0002383)1.82597842
145Pulmonary embolism (HP:0002204)1.78337395
146Intention tremor (HP:0002080)1.77516432
147Anomalous pulmonary venous return (HP:0010772)1.76433394
148Septo-optic dysplasia (HP:0100842)1.75417740
149Arthralgia (HP:0002829)1.75128956
150Cone-rod dystrophy (HP:0000548)1.74271826
151Absent septum pellucidum (HP:0001331)1.73890257
152Esophageal atresia (HP:0002032)1.73722651
153Abnormality of proline metabolism (HP:0010907)1.73110003
154Hydroxyprolinuria (HP:0003080)1.73110003
155Keratitis (HP:0000491)1.72866411
156Basal ganglia calcification (HP:0002135)1.70785108
157Eosinophilia (HP:0001880)1.70211459
158Abnormal auditory evoked potentials (HP:0006958)1.69151255
159Porencephaly (HP:0002132)1.68970900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.32993557
2EPHB14.08932718
3MAP3K144.08830669
4TNIK3.44681439
5MST43.37582322
6OXSR13.14699843
7BCR2.81179174
8IRAK32.81164451
9TAOK22.65584113
10IRAK42.62431044
11TBK12.40208661
12FGR2.38226836
13NME22.38073551
14WNK42.36365519
15PBK2.23927271
16TXK2.15183619
17IKBKB2.10814619
18ERN12.06151707
19MATK2.04825326
20BLK1.88824782
21IKBKE1.73838712
22ADRBK21.70317434
23MAP3K131.69531570
24PKN11.69257410
25ARAF1.66694293
26ICK1.62100448
27ERBB41.59393857
28MET1.58213452
29CDK191.56890297
30BMPR21.49757234
31EPHA31.49324174
32TAOK31.43886577
33DDR21.43664071
34MARK31.43303547
35MAP3K111.31723669
36IRAK11.30437278
37ZAP701.29680446
38MAP3K31.28435432
39CHUK1.28279464
40CSK1.25398277
41WNK11.20380799
42PIM11.16752480
43JAK31.15980786
44KSR21.12892552
45TAOK11.11508076
46PRKCQ1.07991094
47BTK1.06069731
48CLK11.05463892
49NTRK11.03837197
50RIPK11.03021446
51SIK31.01572009
52FGFR20.99404221
53MAP3K10.99071743
54TEC0.97427172
55ROCK20.96275792
56MAP3K90.95187210
57MAP2K30.93789091
58LIMK10.93090735
59NUAK10.91418698
60IRAK20.90011561
61MAP4K10.89858713
62NLK0.87603629
63MAP3K50.87197856
64PRPF4B0.87011086
65NEK60.86299981
66PIM20.83936441
67CSNK1A1L0.81197370
68CDC42BPA0.79877126
69BMPR1B0.79653927
70UHMK10.78278181
71MELK0.78268850
72GRK70.77037738
73PAK60.75514521
74CSNK1G30.74463161
75STK100.71722538
76EPHA20.67496278
77SIK20.67355291
78FYN0.61298165
79EPHB20.61187733
80EIF2AK20.59389689
81BMX0.59187525
82LYN0.57770706
83ABL10.56575635
84ABL20.56098104
85PRKCD0.54865488
86LCK0.53928229
87RAF10.52260109
88CAMK2D0.49615029
89PRKCE0.48441078
90MAPK110.47462346
91MAPKAPK50.46981317
92JAK20.46387037
93ITK0.46001216
94CSNK1G10.45849428
95HIPK20.43347797
96BRAF0.42621864
97PAK30.42253939
98RIPK40.42240241
99CSF1R0.41144684
100HCK0.39977765
101MAP3K80.39892699
102TGFBR20.39791307
103PDK10.39635205
104CDK40.39171386
105BCKDK0.38868924
106MAP2K60.37853090
107CDK140.37414294
108KSR10.37074319
109DYRK20.36490219
110TESK20.36048830
111CAMK2B0.35494908
112RPS6KA50.35200660
113MOS0.35061831
114EIF2AK30.34041917
115TYRO30.33900664
116JAK10.33876773
117STK30.33329199
118TYK20.33193178
119DYRK1B0.33090201
120PDK20.32566805
121STK110.32563024
122FGFR40.32047171
123FES0.32009198
124MAPK40.31635131
125ADRBK10.31496833
126CSNK1G20.31088053
127INSR0.29795032
128TLK10.29230825
129LRRK20.28582264
130PTK60.28129845
131TRPM70.28125781
132GRK60.28120707
133EGFR0.27424641
134PRKCG0.27311441
135CSNK1D0.26519648
136CAMK2A0.25760693
137CSNK1A10.24290511
138MAPKAPK20.23406693
139TNK20.22638049
140SYK0.22312465
141CDK50.21833427
142MST1R0.21433471
143PAK10.20895329
144CDK60.18320477
145MAPK30.18126441
146FGFR30.17380493
147RPS6KA10.15740485
148PDPK10.15487928
149DYRK30.14511101

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.30650120
2Type I diabetes mellitus_Homo sapiens_hsa049404.23218266
3Allograft rejection_Homo sapiens_hsa053304.19578497
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.88947821
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.75901222
6Leishmaniasis_Homo sapiens_hsa051402.67110970
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.65522922
8* Rheumatoid arthritis_Homo sapiens_hsa053232.64272757
9Legionellosis_Homo sapiens_hsa051342.63650760
10Steroid biosynthesis_Homo sapiens_hsa001002.62430153
11* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44227242
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.43973538
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.41681169
14Malaria_Homo sapiens_hsa051442.32484306
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30585008
16African trypanosomiasis_Homo sapiens_hsa051432.28170534
17Autoimmune thyroid disease_Homo sapiens_hsa053202.19648980
18Asthma_Homo sapiens_hsa053102.17134705
19Salmonella infection_Homo sapiens_hsa051322.02395195
20* Pertussis_Homo sapiens_hsa051331.82004931
21* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70379006
22TNF signaling pathway_Homo sapiens_hsa046681.55383428
23Measles_Homo sapiens_hsa051621.51664121
24Hematopoietic cell lineage_Homo sapiens_hsa046401.51224128
25Other glycan degradation_Homo sapiens_hsa005111.47991059
26Staphylococcus aureus infection_Homo sapiens_hsa051501.46402228
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.45117953
28* Tuberculosis_Homo sapiens_hsa051521.43477254
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41453949
30Osteoclast differentiation_Homo sapiens_hsa043801.34327223
31Ether lipid metabolism_Homo sapiens_hsa005651.32231527
32Fatty acid elongation_Homo sapiens_hsa000621.32038054
33Amoebiasis_Homo sapiens_hsa051461.15703839
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15396545
35Prion diseases_Homo sapiens_hsa050201.15299122
36Chemokine signaling pathway_Homo sapiens_hsa040621.13608538
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11543023
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07878730
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05946518
40Acute myeloid leukemia_Homo sapiens_hsa052211.04689121
41Influenza A_Homo sapiens_hsa051640.97022906
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91746293
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91532689
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90163512
45Toxoplasmosis_Homo sapiens_hsa051450.84989622
46Phagosome_Homo sapiens_hsa041450.83638062
47Hepatitis C_Homo sapiens_hsa051600.78533979
48* Jak-STAT signaling pathway_Homo sapiens_hsa046300.77196997
49Herpes simplex infection_Homo sapiens_hsa051680.75207335
50Prolactin signaling pathway_Homo sapiens_hsa049170.74135366
51Shigellosis_Homo sapiens_hsa051310.70726880
52Collecting duct acid secretion_Homo sapiens_hsa049660.70333999
53Axon guidance_Homo sapiens_hsa043600.69316756
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68494671
55Histidine metabolism_Homo sapiens_hsa003400.66942863
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65084524
57VEGF signaling pathway_Homo sapiens_hsa043700.61729551
58Viral myocarditis_Homo sapiens_hsa054160.57583774
59Primary immunodeficiency_Homo sapiens_hsa053400.57506886
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56569405
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55311214
62Sphingolipid metabolism_Homo sapiens_hsa006000.54458042
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53887164
64Bladder cancer_Homo sapiens_hsa052190.53672281
65Linoleic acid metabolism_Homo sapiens_hsa005910.53496187
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.53478699
67Protein export_Homo sapiens_hsa030600.52213674
68HTLV-I infection_Homo sapiens_hsa051660.51781132
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51311180
70T cell receptor signaling pathway_Homo sapiens_hsa046600.50977106
71Type II diabetes mellitus_Homo sapiens_hsa049300.50903787
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47310509
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46296495
74Arachidonic acid metabolism_Homo sapiens_hsa005900.44815366
75Systemic lupus erythematosus_Homo sapiens_hsa053220.44558671
76Arginine and proline metabolism_Homo sapiens_hsa003300.44411637
77Viral carcinogenesis_Homo sapiens_hsa052030.43644378
78Lysosome_Homo sapiens_hsa041420.41585849
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41120169
80Oxidative phosphorylation_Homo sapiens_hsa001900.40961688
81Hepatitis B_Homo sapiens_hsa051610.40774802
82B cell receptor signaling pathway_Homo sapiens_hsa046620.40431729
83Proteasome_Homo sapiens_hsa030500.39558414
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39232175
85Ovarian steroidogenesis_Homo sapiens_hsa049130.38001147
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37125901
87Sulfur metabolism_Homo sapiens_hsa009200.35408764
88Vibrio cholerae infection_Homo sapiens_hsa051100.34691764
89Ras signaling pathway_Homo sapiens_hsa040140.34503220
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.32690806
91Apoptosis_Homo sapiens_hsa042100.32435691
92Complement and coagulation cascades_Homo sapiens_hsa046100.31614512
93Chronic myeloid leukemia_Homo sapiens_hsa052200.30283414
94MAPK signaling pathway_Homo sapiens_hsa040100.30089271
95HIF-1 signaling pathway_Homo sapiens_hsa040660.29610987
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29471561
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.29165536
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28152175
99Endocytosis_Homo sapiens_hsa041440.27203359
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.26727697
101Renal cell carcinoma_Homo sapiens_hsa052110.25325735
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24688826
103Pancreatic cancer_Homo sapiens_hsa052120.24598259
104Insulin resistance_Homo sapiens_hsa049310.22589754
105Serotonergic synapse_Homo sapiens_hsa047260.22087245
106Antigen processing and presentation_Homo sapiens_hsa046120.21475361
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21352255
108Alzheimers disease_Homo sapiens_hsa050100.21238030
109Butanoate metabolism_Homo sapiens_hsa006500.20316854
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.18406373
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.17672556
112FoxO signaling pathway_Homo sapiens_hsa040680.16242114
113Epstein-Barr virus infection_Homo sapiens_hsa051690.15969070
114Dorso-ventral axis formation_Homo sapiens_hsa043200.14850421
115Fructose and mannose metabolism_Homo sapiens_hsa000510.13845623
116ECM-receptor interaction_Homo sapiens_hsa045120.13760089
117Small cell lung cancer_Homo sapiens_hsa052220.13141641
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.12378322
119Glutathione metabolism_Homo sapiens_hsa004800.11033432
120Proteoglycans in cancer_Homo sapiens_hsa052050.10805539
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.10247375
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09992768
123mTOR signaling pathway_Homo sapiens_hsa041500.09727460
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09568853
125Ribosome_Homo sapiens_hsa030100.08760330
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08028748
127Basal transcription factors_Homo sapiens_hsa030220.07021384
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06963860
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06788146
130Non-small cell lung cancer_Homo sapiens_hsa052230.04968406
131Mineral absorption_Homo sapiens_hsa049780.04882790
132Galactose metabolism_Homo sapiens_hsa000520.01567293
133Prostate cancer_Homo sapiens_hsa052150.00910027
134Homologous recombination_Homo sapiens_hsa03440-0.0066637

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