IL24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)8.78049631
2negative regulation of macrophage differentiation (GO:0045650)8.10784151
3regulation of interleukin-5 production (GO:0032674)7.83451560
4negative regulation of interferon-gamma production (GO:0032689)7.37713697
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)7.07485146
6endocrine hormone secretion (GO:0060986)6.40353618
7nucleotide transmembrane transport (GO:1901679)6.26028370
8keratinization (GO:0031424)6.21185899
9regulation of T-helper 1 type immune response (GO:0002825)6.11224196
10maturation of 5.8S rRNA (GO:0000460)5.85647252
11regulation of macrophage activation (GO:0043030)5.74998402
12mesodermal cell differentiation (GO:0048333)5.65952926
13response to follicle-stimulating hormone (GO:0032354)5.55036781
14regulation of macrophage differentiation (GO:0045649)5.50938949
15skin morphogenesis (GO:0043589)5.40039402
16regulation of endothelial cell differentiation (GO:0045601)5.38045925
17hemoglobin metabolic process (GO:0020027)5.36548585
18regulation of podosome assembly (GO:0071801)5.21849438
19negative regulation of protein oligomerization (GO:0032460)5.16616616
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)5.16475509
21negative regulation of adaptive immune response based on somatic recombination of immune receptors b5.16096575
22eyelid development in camera-type eye (GO:0061029)4.97390650
23hypotonic response (GO:0006971)4.84277872
24protein import into peroxisome matrix (GO:0016558)4.81380257
25cell-substrate junction assembly (GO:0007044)4.72833180
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68270665
27negative regulation of cell killing (GO:0031342)4.68270665
28cellular response to sterol (GO:0036315)4.67473764
29negative regulation of adaptive immune response (GO:0002820)4.66288797
30regulation of interferon-gamma biosynthetic process (GO:0045072)4.60400397
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.56821256
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.46424787
33nuclear pore complex assembly (GO:0051292)4.45879894
34desmosome organization (GO:0002934)4.41830402
35regulation of B cell differentiation (GO:0045577)4.39048008
36T-helper 1 type immune response (GO:0042088)4.37851418
37positive regulation of mitotic sister chromatid separation (GO:1901970)4.33732028
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.33732028
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.33732028
40cell adhesion mediated by integrin (GO:0033627)4.32505854
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29292801
42lung lobe morphogenesis (GO:0060463)4.25007799
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.18472304
44positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.14057772
45positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)4.04886079
46lipopolysaccharide biosynthetic process (GO:0009103)4.03310945
47cellular response to cholesterol (GO:0071397)3.99004572
48antigen processing and presentation of endogenous antigen (GO:0019883)3.93088122
49keratinocyte differentiation (GO:0030216)3.87949535
50substrate-dependent cell migration (GO:0006929)3.87729846
51interferon-gamma secretion (GO:0072643)3.86285146
52lipopolysaccharide metabolic process (GO:0008653)3.82532519
53tolerance induction (GO:0002507)3.82101655
54nuclear pore organization (GO:0006999)3.76389315
55tyrosine phosphorylation of STAT protein (GO:0007260)3.72731373
56response to sterol (GO:0036314)3.72544699
57hepatocyte differentiation (GO:0070365)3.69119690
58mannose metabolic process (GO:0006013)3.68365906
59positive regulation of immune response to tumor cell (GO:0002839)3.68204058
60regulation of immune response to tumor cell (GO:0002837)3.68204058
61regulation of response to tumor cell (GO:0002834)3.68204058
62positive regulation of response to tumor cell (GO:0002836)3.68204058
63regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.63734743
64positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.63734743
65positive regulation of macrophage differentiation (GO:0045651)3.61960620
66regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.61954747
67molting cycle (GO:0042303)3.61016494
68hair cycle (GO:0042633)3.61016494
69histone H4-K12 acetylation (GO:0043983)3.54636906
70macrophage activation involved in immune response (GO:0002281)3.53081035
71macroautophagy (GO:0016236)3.50204607
72regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.48805615
73positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.48805615
74positive regulation of Rho protein signal transduction (GO:0035025)3.48391400
75positive regulation of natural killer cell differentiation (GO:0032825)3.46438432
76regulation of interferon-gamma production (GO:0032649)3.45981976
77negative regulation of glycogen biosynthetic process (GO:0045719)3.39570403
78positive regulation of erythrocyte differentiation (GO:0045648)3.34400211
79positive regulation of chemokine production (GO:0032722)3.28835945
80RNA stabilization (GO:0043489)3.28308204
81mRNA stabilization (GO:0048255)3.28308204
82L-serine transport (GO:0015825)3.27909843
83mitotic sister chromatid cohesion (GO:0007064)3.26349928
84positive regulation of astrocyte differentiation (GO:0048711)3.26188010
85negative regulation of axon extension involved in axon guidance (GO:0048843)3.23691556
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22030116
87establishment of endothelial barrier (GO:0061028)3.20293827
88regulation of protein homooligomerization (GO:0032462)3.17715894
89negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)3.17689444
90chondroitin sulfate biosynthetic process (GO:0030206)3.16876090
91response to cholesterol (GO:0070723)3.13800364
92regulation of interleukin-12 biosynthetic process (GO:0045075)3.13638036
93trophoblast giant cell differentiation (GO:0060707)3.12357940
94positive regulation of isotype switching (GO:0045830)3.10914461
95regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.10727931
96positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.10727931
97negative regulation of Ras GTPase activity (GO:0034261)3.10701446
98DNA deamination (GO:0045006)3.08384841
99pore complex assembly (GO:0046931)3.07996151
100keratinocyte proliferation (GO:0043616)3.04666649
101negative regulation of keratinocyte proliferation (GO:0010839)3.03538920
102protein targeting to peroxisome (GO:0006625)3.03243347
103establishment of protein localization to peroxisome (GO:0072663)3.03243347
104protein localization to peroxisome (GO:0072662)3.03243347
105negative regulation of necroptotic process (GO:0060546)3.03173741
106antigen processing and presentation via MHC class Ib (GO:0002475)3.03042443
107cellular response to interferon-alpha (GO:0035457)3.02664058
108negative regulation of innate immune response (GO:0045824)3.01377475
109response to interleukin-15 (GO:0070672)3.00795310
110serine transport (GO:0032329)3.00703870
111regulation of membrane protein ectodomain proteolysis (GO:0051043)2.98640295
112positive regulation of immunoglobulin production (GO:0002639)2.96558955
113positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.94836402
114positive regulation of mRNA catabolic process (GO:0061014)2.94058897
115positive regulation of T cell chemotaxis (GO:0010820)2.93013160
116regulation of T cell chemotaxis (GO:0010819)2.93013160
117polyamine biosynthetic process (GO:0006596)2.91893264
118negative regulation of B cell proliferation (GO:0030889)2.91188818
119peroxisomal transport (GO:0043574)2.90959331
120regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.90049704
121regulation of immunoglobulin secretion (GO:0051023)2.89325331
122peptide cross-linking (GO:0018149)2.88492670
123regulation of T cell mediated cytotoxicity (GO:0001914)2.87526742
124lymphangiogenesis (GO:0001946)2.86782895
125epidermis development (GO:0008544)2.86573506
126cellular response to gonadotropin stimulus (GO:0071371)2.86306195
127regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.86070818
128positive regulation of DNA recombination (GO:0045911)2.83848545
129adaptation of signaling pathway (GO:0023058)2.82201127
130regulation of cytokine secretion involved in immune response (GO:0002739)2.80928041
131negative regulation of cytokine biosynthetic process (GO:0042036)2.80855589
132nucleotide transport (GO:0006862)2.79287201
133positive regulation of immunoglobulin mediated immune response (GO:0002891)2.77871093
134positive regulation of B cell mediated immunity (GO:0002714)2.77871093
135hepatocyte apoptotic process (GO:0097284)2.77389549
136leukocyte aggregation (GO:0070486)2.76970197
137muscle organ morphogenesis (GO:0048644)2.76788684
138ER overload response (GO:0006983)2.75671869
139cellular biogenic amine catabolic process (GO:0042402)2.75182677
140amine catabolic process (GO:0009310)2.75182677
141growth hormone receptor signaling pathway (GO:0060396)2.74701289
142regulation of DNA endoreduplication (GO:0032875)2.73128266
143regulation of natural killer cell differentiation (GO:0032823)2.70015825
144positive regulation of protein export from nucleus (GO:0046827)2.69634955
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68383472
146negative regulation of immune response (GO:0050777)2.68332262
147hippo signaling (GO:0035329)2.67374840
148positive regulation of gamma-delta T cell activation (GO:0046645)2.67268211
149renal filtration (GO:0097205)2.66601263
150regulation of cytokine production involved in inflammatory response (GO:1900015)2.66339617
151epidermal cell differentiation (GO:0009913)2.66192494
152positive regulation of T cell cytokine production (GO:0002726)2.65259951
153negative regulation of glycogen metabolic process (GO:0070874)2.64978200
154NLS-bearing protein import into nucleus (GO:0006607)2.63731398
155negative regulation of B cell activation (GO:0050869)2.62766597
156regulation of natural killer cell mediated immunity (GO:0002715)2.62488332
157regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62488332
158regulation of adaptive immune response based on somatic recombination of immune receptors built from2.62315964
159regulation of isotype switching to IgG isotypes (GO:0048302)2.61794744
160T cell apoptotic process (GO:0070231)2.61773090
161protein localization to kinetochore (GO:0034501)2.61695156
162positive regulation of mast cell activation (GO:0033005)2.61610825
163venous blood vessel morphogenesis (GO:0048845)2.59935764
164positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.58342617
165regulation of B cell receptor signaling pathway (GO:0050855)2.57174964
166negative regulation of cardiac muscle tissue growth (GO:0055022)2.55885123
167negative regulation of heart growth (GO:0061117)2.55885123
168positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.55365337
169regulation of alkaline phosphatase activity (GO:0010692)2.55119488
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54896020
171regulation of immunoglobulin production (GO:0002637)2.54305548
172myeloid dendritic cell differentiation (GO:0043011)2.53803312
173positive regulation of actin filament depolymerization (GO:0030836)2.52781073
174negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.52393214
175regulation of mRNA catabolic process (GO:0061013)2.51718783
176lymphocyte apoptotic process (GO:0070227)2.51085478
177positive regulation of mast cell activation involved in immune response (GO:0033008)2.50901017
178positive regulation of mast cell degranulation (GO:0043306)2.50901017
179regulation of adaptive immune response (GO:0002819)2.50503351
180interferon-gamma production (GO:0032609)2.50327593
181positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50115327
182negative regulation of fatty acid transport (GO:2000192)2.49945635
183regulation of endothelial cell chemotaxis (GO:2001026)2.48835562
184regulation of interleukin-2 biosynthetic process (GO:0045076)2.47958743
185keratinocyte development (GO:0003334)2.44245166
186leukocyte apoptotic process (GO:0071887)2.43762644
187regulation of integrin activation (GO:0033623)2.43713139
188regulation of B cell proliferation (GO:0030888)2.43138330
189positive regulation of chemokine secretion (GO:0090197)13.8902993
190regulation of chemokine secretion (GO:0090196)12.1317809
191positive regulation of macrophage activation (GO:0043032)11.0045876
192hemidesmosome assembly (GO:0031581)10.2224231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.07236292
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.33494900
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.24963244
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.13932027
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.99986276
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.82306104
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.65124482
8E2F7_22180533_ChIP-Seq_HELA_Human3.35151599
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06696621
10SCL_19346495_ChIP-Seq_HPC-7_Human2.99892289
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.97512471
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.80694236
13AR_21909140_ChIP-Seq_LNCAP_Human2.65262162
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.57522852
15* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.57035273
16* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.57035273
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55070154
18* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52340985
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.47170656
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.36939677
21* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27637413
22MYC_22102868_ChIP-Seq_BL_Human2.25932337
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13756766
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.12287671
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.11933014
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.11791173
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06985874
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06889024
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03223853
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02666209
31TP63_17297297_ChIP-ChIP_HaCaT_Human10.6056399
32CLOCK_20551151_ChIP-Seq_293T_Human1.99697303
33SPI1_23547873_ChIP-Seq_NB4_Human1.98766866
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97127773
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89303201
36ATF3_27146783_Chip-Seq_COLON_Human1.85063803
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84655382
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84502290
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81884813
40* ELK1_22589737_ChIP-Seq_MCF10A_Human1.81094073
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81063516
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.78363160
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77054818
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73226288
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.69740928
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69260135
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.68013561
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67771751
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67108990
50ZNF263_19887448_ChIP-Seq_K562_Human1.65391784
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.63708438
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63534393
53* MAF_26560356_Chip-Seq_TH2_Human1.63433074
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59749463
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57870890
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.56593106
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.56454608
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.56057557
59MAF_26560356_Chip-Seq_TH1_Human1.53457491
60* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53206298
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49637455
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49579494
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47699917
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46631226
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39894128
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38397413
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37894835
68* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36814803
69RUNX_20019798_ChIP-Seq_JUKART_Human1.36548824
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36481546
71TCF7_22412390_ChIP-Seq_EML_Mouse1.35042154
72GATA6_25053715_ChIP-Seq_YYC3_Human1.34957075
73BRD4_25478319_ChIP-Seq_HGPS_Human1.33192666
74KDM2B_26808549_Chip-Seq_DND41_Human1.32063410
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31023086
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30884005
77CJUN_26792858_Chip-Seq_BT549_Human1.30699343
78* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30646239
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30290953
80MYB_26560356_Chip-Seq_TH2_Human1.28810812
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.27232914
82* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26845640
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25749169
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.22881215
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22633243
86SOX2_20726797_ChIP-Seq_SW620_Human1.20936752
87MYB_26560356_Chip-Seq_TH1_Human1.20114069
88CIITA_25753668_ChIP-Seq_RAJI_Human1.19880153
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18417908
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17713755
91CHD1_26751641_Chip-Seq_LNCaP_Human1.16676444
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15717768
93* TCF4_18268006_ChIP-ChIP_LS174T_Human1.15019013
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.14941969
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14767411
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14363342
97FOXP3_21729870_ChIP-Seq_TREG_Human1.13947332
98KDM5A_27292631_Chip-Seq_BREAST_Human1.13803568
99VDR_24763502_ChIP-Seq_THP-1_Human1.13592822
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13365779
101VDR_21846776_ChIP-Seq_THP-1_Human1.12625838
102VDR_23849224_ChIP-Seq_CD4+_Human1.12449517
103MYC_18555785_ChIP-Seq_MESCs_Mouse1.11890432
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10236743
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09954407
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.08337981
107* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08289917
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06997101
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06855078
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06624534
111* GATA3_24758297_ChIP-Seq_MCF-7_Human1.06241524
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05311335
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04868453
114SPI1_23127762_ChIP-Seq_K562_Human1.04669380
115GATA1_19941826_ChIP-Seq_K562_Human1.04531598
116EGR1_19032775_ChIP-ChIP_M12_Human1.03905531
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03639050
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03211777
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03152848
120* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02286978
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02235639
122PU_27001747_Chip-Seq_BMDM_Mouse1.01984434
123JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99234843
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99108650
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97901395
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.97870850
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97668977
128FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96382791
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.95641277
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95548094
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95254104
132GATA1_22025678_ChIP-Seq_K562_Human0.94601749
133VDR_24787735_ChIP-Seq_THP-1_Human0.93844775
134UTX_26944678_Chip-Seq_JUKART_Human0.93792785
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92891291
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92749074
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92041923
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91870413
139KLF5_25053715_ChIP-Seq_YYC3_Human0.91605306
140E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90741935
141TP53_18474530_ChIP-ChIP_U2OS_Human0.90617534
142MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90350233
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90125709
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89661658
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.88798253
146* TP63_23658742_ChIP-Seq_EP156T_Human0.87951932
147GATA3_26560356_Chip-Seq_TH2_Human0.87737648
148STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87151109
149TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87141705
150* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87103527
151* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87055921
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86785186
153FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85986566
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.85736347
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84654447
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81664651
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80524421
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79056031
159GATA4_25053715_ChIP-Seq_YYC3_Human0.77894582
160GATA3_27048872_Chip-Seq_THYMUS_Human0.77223776
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76294362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.16844406
2MP0005670_abnormal_white_adipose4.89478029
3MP0005187_abnormal_penis_morphology4.45320193
4MP0003300_gastrointestinal_ulcer3.87853141
5MP0010234_abnormal_vibrissa_follicle3.71955167
6MP0003303_peritoneal_inflammation3.43669070
7MP0003705_abnormal_hypodermis_morpholog3.42966251
8MP0002009_preneoplasia3.19822943
9MP0005171_absent_coat_pigmentation3.14965887
10MP0003453_abnormal_keratinocyte_physiol3.01891919
11MP0002796_impaired_skin_barrier3.01129060
12MP0003315_abnormal_perineum_morphology2.95693341
13MP0000579_abnormal_nail_morphology2.94875735
14MP0010352_gastrointestinal_tract_polyps2.94240305
15MP0003566_abnormal_cell_adhesion2.81624847
16MP0005275_abnormal_skin_tensile2.68285591
17MP0001873_stomach_inflammation2.65282345
18MP0010678_abnormal_skin_adnexa2.62594098
19MP0005501_abnormal_skin_physiology2.61712774
20MP0005023_abnormal_wound_healing2.59093764
21MP0003724_increased_susceptibility_to2.54503653
22MP0000383_abnormal_hair_follicle2.51294074
23MP0000343_altered_response_to2.50543703
24MP0001348_abnormal_lacrimal_gland2.40605794
25MP0003436_decreased_susceptibility_to2.37477025
26MP0001216_abnormal_epidermal_layer2.30149987
27MP0009053_abnormal_anal_canal2.25711892
28MP0002060_abnormal_skin_morphology2.24278157
29MP0001849_ear_inflammation2.20502095
30MP0005076_abnormal_cell_differentiation2.18133404
31MP0003950_abnormal_plasma_membrane2.18071944
32MP0002132_abnormal_respiratory_system2.16956812
33MP0000537_abnormal_urethra_morphology2.10040214
34MP0004947_skin_inflammation1.92629505
35MP0000467_abnormal_esophagus_morphology1.79609858
36MP0010771_integument_phenotype1.77167498
37MP0000377_abnormal_hair_follicle1.74135600
38MP0002419_abnormal_innate_immunity1.73546132
39MP0000427_abnormal_hair_cycle1.71050976
40MP0002876_abnormal_thyroid_physiology1.65389745
41MP0002254_reproductive_system_inflammat1.64876664
42MP0000465_gastrointestinal_hemorrhage1.56964825
43MP0005310_abnormal_salivary_gland1.51618847
44MP0002933_joint_inflammation1.50924079
45MP0002396_abnormal_hematopoietic_system1.50680376
46MP0000627_abnormal_mammary_gland1.50425064
47MP0005164_abnormal_response_to1.49315498
48MP0004272_abnormal_basement_membrane1.48126806
49MP0009278_abnormal_bone_marrow1.47783567
50MP0010368_abnormal_lymphatic_system1.44878902
51MP0003763_abnormal_thymus_physiology1.44453752
52MP0004185_abnormal_adipocyte_glucose1.43993183
53MP0010155_abnormal_intestine_physiology1.42597341
54MP0000647_abnormal_sebaceous_gland1.41182604
55MP0003690_abnormal_glial_cell1.39981751
56MP0000733_abnormal_muscle_development1.36166939
57MP0000762_abnormal_tongue_morphology1.34985619
58MP0002098_abnormal_vibrissa_morphology1.34474906
59MP0002398_abnormal_bone_marrow1.33603282
60MP0005397_hematopoietic_system_phenotyp1.33297606
61MP0001545_abnormal_hematopoietic_system1.33297606
62MP0002998_abnormal_bone_remodeling1.31572519
63MP0001881_abnormal_mammary_gland1.29639696
64MP0000716_abnormal_immune_system1.28077982
65MP0005451_abnormal_body_composition1.23558865
66MP0005387_immune_system_phenotype1.23482307
67MP0001790_abnormal_immune_system1.23482307
68MP0003136_yellow_coat_color1.22553617
69MP0002234_abnormal_pharynx_morphology1.22220039
70MP0004510_myositis1.20435944
71MP0001800_abnormal_humoral_immune1.20372141
72MP0005671_abnormal_response_to1.19957709
73MP0009333_abnormal_splenocyte_physiolog1.19087891
74MP0001299_abnormal_eye_distance/1.17702502
75MP0009931_abnormal_skin_appearance1.15496253
76MP0001191_abnormal_skin_condition1.14537193
77MP0005000_abnormal_immune_tolerance1.14462430
78MP0003448_altered_tumor_morphology1.14209367
79MP0003091_abnormal_cell_migration1.11437121
80MP0004957_abnormal_blastocyst_morpholog1.11240646
81MP0002429_abnormal_blood_cell1.08771639
82MP0004197_abnormal_fetal_growth/weight/1.07285733
83MP0000858_altered_metastatic_potential1.06594021
84MP0004381_abnormal_hair_follicle1.05102555
85MP0001243_abnormal_dermal_layer1.03644836
86MP0000703_abnormal_thymus_morphology1.03038052
87MP0004782_abnormal_surfactant_physiolog1.02789171
88MP0003045_fibrosis1.02259916
89MP0001533_abnormal_skeleton_physiology1.02028743
90MP0001851_eye_inflammation1.01277857
91MP0003866_abnormal_defecation1.01039965
92MP0002006_tumorigenesis0.99090665
93MP0003693_abnormal_embryo_hatching0.98940247
94MP0005623_abnormal_meninges_morphology0.98836825
95MP0001835_abnormal_antigen_presentation0.97760459
96MP0004808_abnormal_hematopoietic_stem0.97324271
97MP0002722_abnormal_immune_system0.95400222
98MP0001853_heart_inflammation0.91943751
99MP0002405_respiratory_system_inflammati0.91842602
100MP0001986_abnormal_taste_sensitivity0.90107155
101MP0004858_abnormal_nervous_system0.88494389
102MP0009785_altered_susceptibility_to0.88405622
103MP0002452_abnormal_antigen_presenting0.86784666
104MP0000689_abnormal_spleen_morphology0.86550111
105MP0001958_emphysema0.86436720
106MP0000685_abnormal_immune_system0.86152064
107MP0002277_abnormal_respiratory_mucosa0.85367704
108MP0008789_abnormal_olfactory_epithelium0.84840836
109MP0008469_abnormal_protein_level0.83974198
110MP0008438_abnormal_cutaneous_collagen0.83063161
111MP0009840_abnormal_foam_cell0.82948021
112MP0000750_abnormal_muscle_regeneration0.82700165
113MP0008877_abnormal_DNA_methylation0.81197409
114MP0005666_abnormal_adipose_tissue0.80794370
115MP0002086_abnormal_extraembryonic_tissu0.80651566
116MP0001915_intracranial_hemorrhage0.79448615
117MP0004264_abnormal_extraembryonic_tissu0.77761819
118MP0002877_abnormal_melanocyte_morpholog0.76739406
119MP0002723_abnormal_immune_serum0.76355533
120MP0003806_abnormal_nucleotide_metabolis0.76232203
121MP0004484_altered_response_of0.75725232
122MP0005595_abnormal_vascular_smooth0.74404236
123MP0005464_abnormal_platelet_physiology0.73806862
124MP0001663_abnormal_digestive_system0.73796983
125MP0001119_abnormal_female_reproductive0.73645309
126MP0002282_abnormal_trachea_morphology0.73517370
127MP0001346_abnormal_lacrimal_gland0.72008799
128MP0009764_decreased_sensitivity_to0.71691678
129MP0002420_abnormal_adaptive_immunity0.71245960
130MP0005025_abnormal_response_to0.70782176
131MP0001730_embryonic_growth_arrest0.70560957
132MP0002148_abnormal_hypersensitivity_rea0.70197009
133MP0000350_abnormal_cell_proliferation0.69417498
134MP0001819_abnormal_immune_cell0.69111250
135MP0001845_abnormal_inflammatory_respons0.69058866
136MP0006054_spinal_hemorrhage0.68484570
137MP0000477_abnormal_intestine_morphology0.68148910
138MP0005166_decreased_susceptibility_to0.68121053
139MP0003828_pulmonary_edema0.67815719
140MP0001784_abnormal_fluid_regulation0.67086566
141MP0009763_increased_sensitivity_to0.67012420
142MP0002019_abnormal_tumor_incidence0.66771430
143MP0002166_altered_tumor_susceptibility0.66740755
144MP0004084_abnormal_cardiac_muscle0.65841651
145MP0010630_abnormal_cardiac_muscle0.65514935
146MP0005165_increased_susceptibility_to0.64966254
147MP0000920_abnormal_myelination0.64863349
148MP0002896_abnormal_bone_mineralization0.64417315
149MP0000367_abnormal_coat/_hair0.63264190
150MP0003787_abnormal_imprinting0.62463515
151MP0005394_taste/olfaction_phenotype0.62383230
152MP0005375_adipose_tissue_phenotype0.59334655
153MP0003252_abnormal_bile_duct0.50016165
154MP0003075_altered_response_to0.47940687
155MP0008775_abnormal_heart_ventricle0.47562710
156MP0000613_abnormal_salivary_gland0.45479980
157MP0005584_abnormal_enzyme/coenzyme_acti0.44867234
158MP0003172_abnormal_lysosome_physiology0.44374347

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.90459824
2Milia (HP:0001056)7.64237776
3Fragile nails (HP:0001808)6.34107281
4Atrophic scars (HP:0001075)6.22102552
5Follicular hyperkeratosis (HP:0007502)5.78253488
6Plantar hyperkeratosis (HP:0007556)5.21559002
7Abnormality of nail color (HP:0100643)5.10684736
8Delayed closure of the anterior fontanelle (HP:0001476)5.07090856
9Thick nail (HP:0001805)4.74316439
10Autoimmune thrombocytopenia (HP:0001973)4.65437975
11Flat occiput (HP:0005469)4.59211605
12Brushfield spots (HP:0001088)4.39356243
13Nail dystrophy (HP:0008404)4.26525675
14Papilledema (HP:0001085)4.24234936
15Rectal prolapse (HP:0002035)4.04167074
16Recurrent cutaneous fungal infections (HP:0011370)3.75156167
17Chronic mucocutaneous candidiasis (HP:0002728)3.75156167
18Keratitis (HP:0000491)3.68911484
19Autoimmune hemolytic anemia (HP:0001890)3.68835123
20Spastic paraparesis (HP:0002313)3.63924781
21Abnormal blistering of the skin (HP:0008066)3.54861641
22Aplastic anemia (HP:0001915)3.54286958
23Stomatitis (HP:0010280)3.51516557
24Asplenia (HP:0001746)3.51205793
25Recurrent fungal infections (HP:0002841)3.49822201
26Increased density of long bones (HP:0006392)3.49483216
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.34166255
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.27130382
29Aplasia/Hypoplasia of the spleen (HP:0010451)3.24374214
30Right ventricular cardiomyopathy (HP:0011663)3.18756033
31Lymphopenia (HP:0001888)3.16589671
32Gastrointestinal stroma tumor (HP:0100723)3.16329521
33Nasal polyposis (HP:0100582)3.14845790
34Abnormality of T cell physiology (HP:0011840)3.11911991
35Vasculitis (HP:0002633)2.97813854
36Interstitial pulmonary disease (HP:0006530)2.97247203
37Coronal craniosynostosis (HP:0004440)2.97176365
38Agammaglobulinemia (HP:0004432)2.94764084
39Abnormality of T cells (HP:0002843)2.94199740
40Palmoplantar hyperkeratosis (HP:0000972)2.93360605
41Keratoconjunctivitis (HP:0001096)2.88148774
42Pili torti (HP:0003777)2.87251121
43Alopecia of scalp (HP:0002293)2.85347043
44Recurrent bacterial skin infections (HP:0005406)2.82804301
45Abnormality of T cell number (HP:0011839)2.82072893
46Aplasia cutis congenita (HP:0001057)2.76400640
47Palmar hyperkeratosis (HP:0010765)2.75020406
48Ridged nail (HP:0001807)2.74802011
49White forelock (HP:0002211)2.73544297
50Delayed cranial suture closure (HP:0000270)2.71199771
51Fragile skin (HP:0001030)2.67816563
52Blepharitis (HP:0000498)2.62224100
53Hyporeflexia of lower limbs (HP:0002600)2.61919907
54Recurrent skin infections (HP:0001581)2.61640369
55Abnormality of B cell number (HP:0010975)2.60988648
56Abnormality of the nasal mucosa (HP:0000433)2.59155382
57Hypoplasia of dental enamel (HP:0006297)2.57811683
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.54787361
59Osteolytic defects of the hand bones (HP:0009699)2.54787361
60Gastrointestinal infarctions (HP:0005244)2.53306928
61Elevated erythrocyte sedimentation rate (HP:0003565)2.52092559
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.51469989
63Abnormality of macrophages (HP:0004311)2.51277549
64Fatigue (HP:0012378)2.48203089
65Global brain atrophy (HP:0002283)2.47202864
66Oligodontia (HP:0000677)2.45711308
67Eczematoid dermatitis (HP:0000976)2.45469523
68Increased CSF protein (HP:0002922)2.44541976
69Abnormality of chromosome segregation (HP:0002916)2.42480225
70Recurrent abscess formation (HP:0002722)2.40306379
71Recurrent bronchitis (HP:0002837)2.39580531
72Exercise-induced muscle cramps (HP:0003710)2.39225756
73Limb-girdle muscle atrophy (HP:0003797)2.38793125
74Muscle fiber splitting (HP:0003555)2.37657353
75Muscle fiber inclusion bodies (HP:0100299)2.36879923
76Primary adrenal insufficiency (HP:0008207)2.35061729
77Ankyloglossia (HP:0010296)2.34924391
78Granulocytopenia (HP:0001913)2.31856649
79Lymphangioma (HP:0100764)2.31334900
80Patchy hypopigmentation of hair (HP:0011365)2.30549811
81Trismus (HP:0000211)2.29107188
82Recurrent viral infections (HP:0004429)2.28107844
83Increased IgM level (HP:0003496)2.24250513
84Erythema (HP:0010783)2.24230437
85Nemaline bodies (HP:0003798)2.21827181
86Abnormality of incisor morphology (HP:0011063)2.20486417
87Epiphyseal stippling (HP:0010655)2.20438925
88Type I diabetes mellitus (HP:0100651)2.19735111
89Obstructive lung disease (HP:0006536)2.17828556
90Chronic obstructive pulmonary disease (HP:0006510)2.17828556
91Oral leukoplakia (HP:0002745)2.17269989
92Hypochromic anemia (HP:0001931)2.16177246
93Vascular calcification (HP:0004934)2.16009906
94Lymphoma (HP:0002665)2.15841320
95Paraparesis (HP:0002385)2.14552711
96Round ear (HP:0100830)2.13885673
97Abnormality of oral frenula (HP:0000190)2.13551766
98Abnormal protein glycosylation (HP:0012346)2.13147431
99Abnormal glycosylation (HP:0012345)2.13147431
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13147431
101Abnormal protein N-linked glycosylation (HP:0012347)2.13147431
102Hypoparathyroidism (HP:0000829)2.12326234
103Recurrent gram-negative bacterial infections (HP:0005420)2.11845061
104Hyperkalemia (HP:0002153)2.11247864
105Ulnar deviation of the wrist (HP:0003049)2.10870614
106Increased connective tissue (HP:0009025)2.10738483
107Anorexia (HP:0002039)2.10050454
108Abnormal auditory evoked potentials (HP:0006958)2.09273844
109Orchitis (HP:0100796)2.08239045
110Hemorrhage of the eye (HP:0011885)2.06822144
111Distal arthrogryposis (HP:0005684)2.06783389
112Pelvic girdle muscle weakness (HP:0003749)2.06761266
113Myositis (HP:0100614)2.06090967
114Spinal cord lesions (HP:0100561)2.05469775
115Syringomyelia (HP:0003396)2.05469775
116Ureteral stenosis (HP:0000071)2.05036817
117Eosinophilia (HP:0001880)2.03709078
118Abnormality of the gastric mucosa (HP:0004295)2.03054044
119Meningitis (HP:0001287)2.02586093
120Esophageal atresia (HP:0002032)2.01352303
121Deviation of the thumb (HP:0009603)2.00604410
122Anonychia (HP:0001798)1.99843187
123Pterygium (HP:0001059)1.98617963
124Scapular winging (HP:0003691)1.97655204
125IgA deficiency (HP:0002720)1.97247308
126Oligomenorrhea (HP:0000876)1.97065278
127Sparse eyelashes (HP:0000653)1.96995550
128Cardiovascular calcification (HP:0011915)1.96986223
129Frequent falls (HP:0002359)1.96865966
130Large for gestational age (HP:0001520)1.96767354
131Premature graying of hair (HP:0002216)1.95478272
132Back pain (HP:0003418)1.95300948
133Hypotrichosis (HP:0001006)1.95264061
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.94225242
135Woolly hair (HP:0002224)1.93328141
136Subacute progressive viral hepatitis (HP:0006572)1.92924623
137Type 1 muscle fiber predominance (HP:0003803)1.92792481
138Subaortic stenosis (HP:0001682)1.92024290
139Abnormality of the left ventricular outflow tract (HP:0011103)1.92024290
140Calcaneovalgus deformity (HP:0001848)1.91724140
141Emphysema (HP:0002097)1.91570739
142Abnormality of the calcaneus (HP:0008364)1.90557949
143Distal upper limb amyotrophy (HP:0007149)1.90493520
144Upper limb amyotrophy (HP:0009129)1.90493520
145Encephalitis (HP:0002383)1.88960291
146Skin ulcer (HP:0200042)1.88348911
147Achilles tendon contracture (HP:0001771)1.86925293
148Chest pain (HP:0100749)1.86242148
149Cerebral aneurysm (HP:0004944)1.85982184
150Loss of speech (HP:0002371)1.84446477
151Thickened helices (HP:0000391)1.83695831
152Ureteral obstruction (HP:0006000)1.83327135
153Chronic diarrhea (HP:0002028)1.82400537
154Sensory axonal neuropathy (HP:0003390)1.82115237
155Abnormality of the musculature of the pelvis (HP:0001469)1.81958007
156Abnormality of the hip-girdle musculature (HP:0001445)1.81958007
157Lip pit (HP:0100267)1.81639789
158Verrucae (HP:0200043)1.81047009
159Papilloma (HP:0012740)1.81047009
160Proximal placement of thumb (HP:0009623)1.80788783
161Pyloric stenosis (HP:0002021)1.78764720
162Biliary tract neoplasm (HP:0100574)1.76052805
163Distal lower limb muscle weakness (HP:0009053)1.75218030
164Curly hair (HP:0002212)1.75135236
165Cheilitis (HP:0100825)1.74702039
166T lymphocytopenia (HP:0005403)1.74510430
167Abnormality of the pericardium (HP:0001697)1.74420192
168Ectropion (HP:0000656)1.72578515
169Retrobulbar optic neuritis (HP:0100654)1.72312390
170Optic neuritis (HP:0100653)1.72312390
171Abnormality of the nasal septum (HP:0000419)1.71677809
172Abnormality of the Achilles tendon (HP:0005109)1.70856805
173Gangrene (HP:0100758)1.70555868
174Hyperhidrosis (HP:0000975)1.70484354
175Increased IgE level (HP:0003212)1.70075805
176Volvulus (HP:0002580)1.69932303
177Pustule (HP:0200039)1.68421394
178Abnormality of the distal phalanges of the toes (HP:0010182)1.67822987
179Myopathic facies (HP:0002058)1.67792072
180Focal segmental glomerulosclerosis (HP:0000097)1.67692225
181Abnormality of the fingernails (HP:0001231)1.67233563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CLK16.39519695
2EPHA25.66687238
3MAP3K134.53227531
4PASK4.48415081
5PRPF4B3.57154596
6LATS13.20872194
7STK103.04311435
8EPHB12.67853854
9TRIB32.57374358
10DMPK2.39430095
11LRRK22.33330438
12MST1R2.21737165
13MAP4K12.18320327
14PKN22.04627808
15CDK62.03070321
16NME11.99336137
17BMPR21.97075911
18LMTK21.95239115
19TAOK21.94985452
20CDK121.92622746
21ALK1.85553780
22FER1.81850580
23MST41.77345738
24PTK21.76259740
25AKT31.74367884
26CSK1.73009316
27TTN1.72670718
28FGR1.71195121
29IRAK31.69115911
30RPS6KA41.68846490
31TRIM281.62493431
32ERN11.58950941
33TAOK31.57273815
34TYK21.51024608
35PTK61.50820850
36STK31.50470587
37BMX1.50049692
38TXK1.49186628
39MAP3K31.46646466
40IRAK41.39770005
41RPS6KB21.34639918
42CAMKK11.33497755
43PAK21.28779105
44MAP3K121.27267161
45EEF2K1.27096730
46RIPK41.24164249
47MAP3K81.23559553
48ITK1.23543153
49SIK31.23237956
50IKBKB1.22416394
51NEK91.13799368
52JAK31.13265204
53CDK91.10636487
54PIM21.07725908
55BLK1.06627015
56ERBB31.04280444
57GRK61.00656851
58NUAK11.00218481
59EPHB20.97766891
60CDK30.96721625
61TESK10.96338356
62IRAK20.94579233
63MAP3K20.92737314
64BCR0.92341710
65ROCK20.91626710
66PAK40.89917655
67FGFR10.88611818
68RIPK10.88008479
69TGFBR20.87847248
70TSSK60.87535146
71EPHA30.87351062
72MET0.86529892
73IRAK10.85321498
74EGFR0.85059155
75PIK3CG0.83558345
76NEK20.82063403
77LYN0.80786798
78ILK0.80265859
79HCK0.80009538
80NEK10.79771472
81TAOK10.79695633
82SYK0.78219872
83PLK30.77662842
84SIK20.76230562
85FRK0.75930726
86NME20.74630028
87MAP3K70.74229973
88DDR20.73280192
89MAP3K10.71665172
90CDC70.70999906
91MTOR0.69550552
92CDC42BPA0.68752254
93FGFR30.68102829
94FGFR40.68082615
95NEK60.65618050
96JAK20.65265675
97PKN10.65222725
98PDGFRB0.64657036
99PRKD20.64499057
100LCK0.64229431
101TGFBR10.62557338
102MAP2K30.62079511
103CHUK0.61724063
104MARK20.61606517
105MAP3K110.61300219
106GSK3A0.60745791
107IKBKE0.60680682
108MAP3K140.60587080
109INSRR0.57779157
110MAPK110.55883603
111SCYL20.55345981
112MKNK10.55252221
113PHKG20.55119262
114PHKG10.55119262
115PLK20.55037510
116ZAK0.54880551
117LIMK10.53974652
118INSR0.53144793
119FES0.52745216
120AURKB0.52492889
121PTK2B0.51731590
122PDK10.51438674
123BTK0.51367228
124TESK20.50305634
125TEC0.50211672
126EIF2AK10.50196825
127MARK30.49388182
128LATS20.48119535
129PDPK10.47826691
130CSNK1E0.47808550
131MAPKAPK20.47288712
132WNK10.44625087
133TRPM70.44562378
134ZAP700.43795106
135TNK20.42365436
136JAK10.41560523
137PIM10.41483376
138PRKCQ0.40903183
139BRD40.40609852
140DYRK1B0.38737214
141MAP4K20.38523214
142MELK0.36296656
143STK390.35134874
144CSNK1D0.34690933
145MAPK40.34439302
146SIK10.34182088
147CDK40.33290180
148CSNK1A10.32902990
149IGF1R0.31695984
150KDR0.31377394
151PRKG20.30995093
152PRKD30.30868308
153ABL10.30634927
154TBK10.30020260
155ADRBK20.29641726
156STK380.27472838
157HIPK20.27354319
158CSF1R0.25153566
159MAPK30.24719834
160MAPK70.24319915
161STK160.23937019
162FYN0.22250072
163DYRK1A0.22187368
164SGK30.20419075
165PRKCI0.20202433
166MAP3K50.19516624

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005325.08151257
2Asthma_Homo sapiens_hsa053103.19921767
3Allograft rejection_Homo sapiens_hsa053303.07491190
4Small cell lung cancer_Homo sapiens_hsa052222.59355210
5Hematopoietic cell lineage_Homo sapiens_hsa046402.51802037
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51200557
7ECM-receptor interaction_Homo sapiens_hsa045122.34250678
8Type I diabetes mellitus_Homo sapiens_hsa049402.09107110
9T cell receptor signaling pathway_Homo sapiens_hsa046602.02754644
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.97154620
11Autoimmune thyroid disease_Homo sapiens_hsa053201.94434385
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93054736
13Toxoplasmosis_Homo sapiens_hsa051451.91928589
14Proteoglycans in cancer_Homo sapiens_hsa052051.85990232
15Amoebiasis_Homo sapiens_hsa051461.75914341
16Viral myocarditis_Homo sapiens_hsa054161.75739888
17* Jak-STAT signaling pathway_Homo sapiens_hsa046301.67582466
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66322680
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63114830
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61914224
21Focal adhesion_Homo sapiens_hsa045101.56316198
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.49808584
23MicroRNAs in cancer_Homo sapiens_hsa052061.49273117
24Adherens junction_Homo sapiens_hsa045201.48030526
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47969560
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.47254090
27Rheumatoid arthritis_Homo sapiens_hsa053231.44825765
28Antigen processing and presentation_Homo sapiens_hsa046121.43240253
29Malaria_Homo sapiens_hsa051441.41122600
30Graft-versus-host disease_Homo sapiens_hsa053321.39287176
31Leishmaniasis_Homo sapiens_hsa051401.37869632
32TNF signaling pathway_Homo sapiens_hsa046681.34349052
33Chronic myeloid leukemia_Homo sapiens_hsa052201.33868841
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.32006487
35* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30441197
36Thyroid cancer_Homo sapiens_hsa052161.29204009
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27194088
38Renal cell carcinoma_Homo sapiens_hsa052111.24673955
39Shigellosis_Homo sapiens_hsa051311.18968129
40RNA transport_Homo sapiens_hsa030131.17564120
41Influenza A_Homo sapiens_hsa051641.16738603
42HTLV-I infection_Homo sapiens_hsa051661.15039875
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14705050
44Bladder cancer_Homo sapiens_hsa052191.13616142
45Measles_Homo sapiens_hsa051621.13148383
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11335455
47Acute myeloid leukemia_Homo sapiens_hsa052211.11260082
48VEGF signaling pathway_Homo sapiens_hsa043701.10775857
49Viral carcinogenesis_Homo sapiens_hsa052031.10669654
50Dilated cardiomyopathy_Homo sapiens_hsa054141.07480449
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07204547
52Pancreatic cancer_Homo sapiens_hsa052121.06099082
53Other glycan degradation_Homo sapiens_hsa005111.05517592
54Nitrogen metabolism_Homo sapiens_hsa009101.05178135
55Phagosome_Homo sapiens_hsa041451.04405764
56Osteoclast differentiation_Homo sapiens_hsa043801.04350094
57B cell receptor signaling pathway_Homo sapiens_hsa046621.03487161
58Salmonella infection_Homo sapiens_hsa051321.02621770
59Pertussis_Homo sapiens_hsa051331.02082788
60RNA polymerase_Homo sapiens_hsa030201.01866845
61Tight junction_Homo sapiens_hsa045300.99968010
62Platelet activation_Homo sapiens_hsa046110.99233160
63Legionellosis_Homo sapiens_hsa051340.98413990
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97014467
65p53 signaling pathway_Homo sapiens_hsa041150.96449072
66Hippo signaling pathway_Homo sapiens_hsa043900.95918162
67Fatty acid biosynthesis_Homo sapiens_hsa000610.94643025
68Lysosome_Homo sapiens_hsa041420.93813714
69Primary immunodeficiency_Homo sapiens_hsa053400.93562721
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90092032
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86367734
72Hepatitis B_Homo sapiens_hsa051610.84638769
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83490000
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81855082
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81655817
76Pathways in cancer_Homo sapiens_hsa052000.80894392
77Sulfur relay system_Homo sapiens_hsa041220.80593270
78Epstein-Barr virus infection_Homo sapiens_hsa051690.79973320
79Apoptosis_Homo sapiens_hsa042100.79373687
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.78134126
81N-Glycan biosynthesis_Homo sapiens_hsa005100.77337166
82Insulin resistance_Homo sapiens_hsa049310.74481425
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73178674
84FoxO signaling pathway_Homo sapiens_hsa040680.72740125
85Colorectal cancer_Homo sapiens_hsa052100.72339378
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71452042
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71139428
88Cell cycle_Homo sapiens_hsa041100.69335538
89African trypanosomiasis_Homo sapiens_hsa051430.68563901
90Chemokine signaling pathway_Homo sapiens_hsa040620.68414315
91TGF-beta signaling pathway_Homo sapiens_hsa043500.68066288
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67636649
93HIF-1 signaling pathway_Homo sapiens_hsa040660.67311227
94Glioma_Homo sapiens_hsa052140.67111270
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64516336
96Tuberculosis_Homo sapiens_hsa051520.63740898
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62230686
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60851905
99Collecting duct acid secretion_Homo sapiens_hsa049660.59564585
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58813061
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58652922
102Non-small cell lung cancer_Homo sapiens_hsa052230.58360196
103One carbon pool by folate_Homo sapiens_hsa006700.57339631
104Herpes simplex infection_Homo sapiens_hsa051680.56531671
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56363253
106Prolactin signaling pathway_Homo sapiens_hsa049170.55866901
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55690401
108Proteasome_Homo sapiens_hsa030500.55533522
109Endocytosis_Homo sapiens_hsa041440.55303299
110mRNA surveillance pathway_Homo sapiens_hsa030150.54690007
111MAPK signaling pathway_Homo sapiens_hsa040100.54428724
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.52580813
113Hepatitis C_Homo sapiens_hsa051600.52378865
114Endometrial cancer_Homo sapiens_hsa052130.51892329
115Prostate cancer_Homo sapiens_hsa052150.51169515
116Rap1 signaling pathway_Homo sapiens_hsa040150.48252919
117RNA degradation_Homo sapiens_hsa030180.45845213
118GnRH signaling pathway_Homo sapiens_hsa049120.45781235
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45661186
120Axon guidance_Homo sapiens_hsa043600.45060435
121Staphylococcus aureus infection_Homo sapiens_hsa051500.44917245
122Complement and coagulation cascades_Homo sapiens_hsa046100.41767200
123ErbB signaling pathway_Homo sapiens_hsa040120.40797571
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39637490
125Dorso-ventral axis formation_Homo sapiens_hsa043200.38998065
126Pyrimidine metabolism_Homo sapiens_hsa002400.37141566
127Calcium signaling pathway_Homo sapiens_hsa040200.36996362
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35843249
129Circadian rhythm_Homo sapiens_hsa047100.35279024
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35221006
131ABC transporters_Homo sapiens_hsa020100.34440123
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.33211790
133Ribosome_Homo sapiens_hsa030100.30437433
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28467601
135mTOR signaling pathway_Homo sapiens_hsa041500.27217926
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25535029
137Regulation of autophagy_Homo sapiens_hsa041400.23568249

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