IL26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to interleukin-15 (GO:0070672)8.09585143
2positive regulation of osteoclast differentiation (GO:0045672)7.76817288
3cellular response to interleukin-15 (GO:0071350)7.44663348
4regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.19471139
5regulation of interleukin-6 biosynthetic process (GO:0045408)7.12916978
6regulation of immunoglobulin secretion (GO:0051023)7.12815870
7negative regulation of thymocyte apoptotic process (GO:0070244)7.11525255
8myeloid dendritic cell differentiation (GO:0043011)6.68409353
9regulation of interleukin-12 biosynthetic process (GO:0045075)6.48863484
10positive regulation of T cell cytokine production (GO:0002726)6.46773387
11regulation of interleukin-8 biosynthetic process (GO:0045414)6.06348772
12alpha-beta T cell differentiation (GO:0046632)5.87282785
13regulation of interleukin-2 biosynthetic process (GO:0045076)5.82259175
14myeloid dendritic cell activation (GO:0001773)5.72705298
15cytokine biosynthetic process (GO:0042089)5.40756826
16positive regulation of transcription regulatory region DNA binding (GO:2000679)5.39533944
17signal peptide processing (GO:0006465)5.18134237
18alpha-beta T cell activation (GO:0046631)5.02900458
19poly(A)+ mRNA export from nucleus (GO:0016973)4.85920003
20T-helper 1 type immune response (GO:0042088)4.83218108
21negative regulation of T-helper cell differentiation (GO:0045623)4.70984481
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.70984481
23T-helper cell differentiation (GO:0042093)4.70833893
24CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.70833893
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69729820
26negative T cell selection (GO:0043383)4.65091693
27regulation of T cell cytokine production (GO:0002724)4.61595389
28tolerance induction (GO:0002507)4.56865413
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47721848
30positive regulation of myeloid leukocyte differentiation (GO:0002763)4.47409399
31regulation of thymocyte apoptotic process (GO:0070243)4.46367747
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.45710500
33cytokine metabolic process (GO:0042107)4.40600364
34DNA double-strand break processing (GO:0000729)4.39224057
35interleukin-1-mediated signaling pathway (GO:0070498)4.33372818
36regulation of interleukin-2 production (GO:0032663)4.25627963
37negative thymic T cell selection (GO:0045060)4.19245517
38alpha-beta T cell differentiation involved in immune response (GO:0002293)4.16637872
39alpha-beta T cell activation involved in immune response (GO:0002287)4.16637872
40T cell differentiation involved in immune response (GO:0002292)4.16637872
41regulation of B cell receptor signaling pathway (GO:0050855)4.10570256
42NIK/NF-kappaB signaling (GO:0038061)4.02670284
43nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)4.01485454
44negative regulation of T cell apoptotic process (GO:0070233)3.91570035
45CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.90950485
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90362500
47regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.87088461
48antigen processing and presentation of endogenous antigen (GO:0019883)3.78169575
49sleep (GO:0030431)3.73100045
50membrane protein intracellular domain proteolysis (GO:0031293)3.68771941
51regulation of T-helper 1 cell differentiation (GO:0045625)3.68641301
52positive regulation of alpha-beta T cell proliferation (GO:0046641)3.65993114
53CD4-positive, alpha-beta T cell activation (GO:0035710)3.61975446
54lymph node development (GO:0048535)3.61120959
55negative regulation of T cell mediated immunity (GO:0002710)3.59056362
56dendritic cell differentiation (GO:0097028)3.58805168
57tyrosine phosphorylation of STAT protein (GO:0007260)3.58680746
58positive regulation of interleukin-2 production (GO:0032743)3.57706289
59cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)3.54705894
60regulation of regulatory T cell differentiation (GO:0045589)3.53137839
61negative regulation of cell killing (GO:0031342)3.51321710
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51321710
63regulation of immunoglobulin production (GO:0002637)3.50918707
64adenosine metabolic process (GO:0046085)3.50145961
65leukocyte aggregation (GO:0070486)3.48930562
66positive regulation of defense response to virus by host (GO:0002230)3.42161644
67regulation of chronic inflammatory response (GO:0002676)3.36105389
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.28448132
69T cell differentiation (GO:0030217)3.27158067
70regulation of gamma-delta T cell differentiation (GO:0045586)3.26239407
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25019926
72negative regulation of alpha-beta T cell differentiation (GO:0046639)3.23642806
73positive regulation of T cell mediated immunity (GO:0002711)3.23304458
74actin nucleation (GO:0045010)3.20347780
75negative regulation of adaptive immune response (GO:0002820)3.15321690
76positive T cell selection (GO:0043368)3.12180485
77thymic T cell selection (GO:0045061)3.10799041
78regulation of osteoclast differentiation (GO:0045670)3.09215718
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.08346104
80regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.08346104
81cellular response to interleukin-1 (GO:0071347)3.07100547
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.05247745
83mRNA modification (GO:0016556)3.04243448
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02480082
85regulation of T-helper 1 type immune response (GO:0002825)3.02038145
86male sex determination (GO:0030238)3.01873603
87T cell receptor signaling pathway (GO:0050852)2.98408213
88regulation of alpha-beta T cell proliferation (GO:0046640)2.97265707
89positive regulation of myeloid cell differentiation (GO:0045639)2.94704127
90regulation of T cell mediated immunity (GO:0002709)2.94278056
91positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.93821667
92regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.93821667
93positive regulation of mRNA catabolic process (GO:0061014)2.92248168
94positive regulation of T cell differentiation in thymus (GO:0033089)2.90641269
95positive regulation of granulocyte differentiation (GO:0030854)2.90164762
96T cell selection (GO:0045058)2.89464106
97response to muramyl dipeptide (GO:0032495)2.88282828
98natural killer cell activation involved in immune response (GO:0002323)2.84495066
99regulation of T cell mediated cytotoxicity (GO:0001914)2.82657850
100regulation of cytokine production involved in inflammatory response (GO:1900015)14.7425133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.71515224
2FLI1_27457419_Chip-Seq_LIVER_Mouse5.68633011
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.48882084
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.87852362
5* RUNX_20019798_ChIP-Seq_JUKART_Human4.24584789
6PCGF2_27294783_Chip-Seq_ESCs_Mouse4.04701984
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.70667048
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.56002284
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18944229
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16702482
11MYB_26560356_Chip-Seq_TH2_Human2.96255279
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84869820
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.82184864
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.62259656
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.34354162
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.32444036
17EZH2_27294783_Chip-Seq_NPCs_Mouse2.18102216
18SCL_19346495_ChIP-Seq_HPC-7_Human2.13397244
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13231365
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.11498547
21MYB_26560356_Chip-Seq_TH1_Human2.11357913
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09247149
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.03303716
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.97324590
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96166915
26* MAF_26560356_Chip-Seq_TH1_Human1.85796332
27SMAD1_18555785_Chip-Seq_ESCs_Mouse1.76958840
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68368991
29CRX_20693478_ChIP-Seq_RETINA_Mouse1.68332459
30CTCF_18555785_Chip-Seq_ESCs_Mouse1.64652001
31SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.63204378
32* GATA3_27048872_Chip-Seq_THYMUS_Human1.62414179
33PU1_27457419_Chip-Seq_LIVER_Mouse1.61101681
34OCT4_18555785_Chip-Seq_ESCs_Mouse1.60529692
35RUNX1_27457419_Chip-Seq_LIVER_Mouse1.60501436
36GATA3_26560356_Chip-Seq_TH2_Human1.60326809
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59420010
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58360567
39NMYC_18555785_Chip-Seq_ESCs_Mouse1.58239661
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58080883
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.56091342
42GATA1_22025678_ChIP-Seq_K562_Human1.54802939
43P300_18555785_Chip-Seq_ESCs_Mouse1.54188924
44EGR1_19032775_ChIP-ChIP_M12_Human1.51819462
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51551113
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50479615
47MYC_22102868_ChIP-Seq_BL_Human1.49806232
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.48003122
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.47103825
50KLF4_18555785_Chip-Seq_ESCs_Mouse1.46194305
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.45386379
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43655032
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.43315408
54VDR_23849224_ChIP-Seq_CD4+_Human1.41580268
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40642199
56PU_27001747_Chip-Seq_BMDM_Mouse1.39311535
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.39279697
58ESRRB_18555785_Chip-Seq_ESCs_Mouse1.38135469
59MAF_26560356_Chip-Seq_TH2_Human1.36350583
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34763262
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.34006211
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32975836
63P53_22387025_ChIP-Seq_ESCs_Mouse1.32118593
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.31763847
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29219960
66UTX_26944678_Chip-Seq_JUKART_Human1.20735415
67SPI1_23547873_ChIP-Seq_NB4_Human1.15858935
68ZNF274_21170338_ChIP-Seq_K562_Hela1.13429282
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13316885
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12497702
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12462020
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09147197
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08681496
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.08456534
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07312485
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03424640
77HTT_18923047_ChIP-ChIP_STHdh_Human1.02741992
78FOXP3_21729870_ChIP-Seq_TREG_Human1.02655212
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98636911
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98163605
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97920919
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97064548
83NANOG_18555785_Chip-Seq_ESCs_Mouse0.96657670
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94339795
85KDM5A_27292631_Chip-Seq_BREAST_Human0.94072045
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93643318
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90728524
88MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89723722
89GATA3_26560356_Chip-Seq_TH1_Human0.87870317
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85893778
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83968197
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83630731
93STAT1_20625510_ChIP-Seq_HELA_Human0.78711450
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78643399
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76000591
96RUNX1_22412390_ChIP-Seq_EML_Mouse0.75750814
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75498152
98DCP1A_22483619_ChIP-Seq_HELA_Human0.74006544
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71135226
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69582914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation5.33798763
2MP0003436_decreased_susceptibility_to5.01132269
3MP0005387_immune_system_phenotype4.70822025
4MP0001790_abnormal_immune_system4.70822025
5MP0009785_altered_susceptibility_to4.60493011
6MP0005671_abnormal_response_to4.50224154
7MP0001835_abnormal_antigen_presentation3.97827519
8MP0001849_ear_inflammation3.87761088
9MP0010155_abnormal_intestine_physiology3.35474632
10MP0003763_abnormal_thymus_physiology3.00405307
11MP0005000_abnormal_immune_tolerance2.95860230
12MP0001800_abnormal_humoral_immune2.86403581
13MP0002148_abnormal_hypersensitivity_rea2.80563381
14MP0002405_respiratory_system_inflammati2.59886388
15MP0002723_abnormal_immune_serum2.50507221
16MP0001533_abnormal_skeleton_physiology2.41964646
17MP0003724_increased_susceptibility_to2.31541180
18MP0005025_abnormal_response_to2.29589079
19MP0002452_abnormal_antigen_presenting2.19647710
20MP0001873_stomach_inflammation2.04861836
21MP0002420_abnormal_adaptive_immunity2.03390174
22MP0001819_abnormal_immune_cell2.02987327
23MP0008875_abnormal_xenobiotic_pharmacok1.99450715
24MP0002876_abnormal_thyroid_physiology1.99107281
25MP0000685_abnormal_immune_system1.95627853
26MP0001853_heart_inflammation1.95089830
27MP0003866_abnormal_defecation1.81208985
28MP0005310_abnormal_salivary_gland1.76431088
29MP0004947_skin_inflammation1.76386437
30MP0000703_abnormal_thymus_morphology1.71129528
31MP0005187_abnormal_penis_morphology1.65357157
32MP0000490_abnormal_crypts_of1.65338490
33MP0002166_altered_tumor_susceptibility1.63016574
34MP0002722_abnormal_immune_system1.62473573
35MP0001243_abnormal_dermal_layer1.61615787
36MP0000716_abnormal_immune_system1.61486107
37MP0001845_abnormal_inflammatory_respons1.59859281
38MP0002398_abnormal_bone_marrow1.53617388
39MP0000689_abnormal_spleen_morphology1.43366655
40MP0002998_abnormal_bone_remodeling1.41823463
41MP0002254_reproductive_system_inflammat1.40383355
42MP0005390_skeleton_phenotype1.39680886
43MP0003195_calcinosis1.39489920
44MP0008873_increased_physiological_sensi1.39089467
45MP0002095_abnormal_skin_pigmentation1.34419490
46MP0002419_abnormal_innate_immunity1.32328437
47MP0003300_gastrointestinal_ulcer1.29326118
48MP0002429_abnormal_blood_cell1.27169878
49MP0008469_abnormal_protein_level1.16878487
50MP0002006_tumorigenesis1.14713950
51MP0009333_abnormal_splenocyte_physiolog1.11611794
52MP0002138_abnormal_hepatobiliary_system1.09525449
53MP0000465_gastrointestinal_hemorrhage1.02031181
54MP0002396_abnormal_hematopoietic_system1.00473023
55MP0005076_abnormal_cell_differentiation0.99665198
56MP0003303_peritoneal_inflammation0.99116637
57MP0002277_abnormal_respiratory_mucosa0.97319360
58MP0004510_myositis0.95889887
59MP0001216_abnormal_epidermal_layer0.95002875
60MP0001851_eye_inflammation0.92974217
61MP0006082_CNS_inflammation0.91431276
62MP0003828_pulmonary_edema0.90771898
63MP0008569_lethality_at_weaning0.89336458
64MP0005319_abnormal_enzyme/_coenzyme0.86909785
65MP0004019_abnormal_vitamin_homeostasis0.86642746
66MP0001765_abnormal_ion_homeostasis0.85888681
67MP0010030_abnormal_orbit_morphology0.84255241
68MP0009931_abnormal_skin_appearance0.82172049
69MP0001348_abnormal_lacrimal_gland0.75765626
70MP0003252_abnormal_bile_duct0.74971880
71MP0004134_abnormal_chest_morphology0.73196094
72MP0001529_abnormal_vocalization0.71213889
73MP0003795_abnormal_bone_structure0.69068214
74MP0009764_decreased_sensitivity_to0.69017033
75MP0005584_abnormal_enzyme/coenzyme_acti0.67244666
76MP0001663_abnormal_digestive_system0.63411004
77MP0000627_abnormal_mammary_gland0.55679330
78MP0003448_altered_tumor_morphology0.54814310
79MP0008438_abnormal_cutaneous_collagen0.53615397
80MP0001191_abnormal_skin_condition0.52437328
81MP0005379_endocrine/exocrine_gland_phen0.51523133
82MP0008872_abnormal_physiological_respon0.49170702
83MP0001501_abnormal_sleep_pattern0.48660772
84MP0002009_preneoplasia0.48641678
85MP0009763_increased_sensitivity_to0.48327497
86MP0002060_abnormal_skin_morphology0.47313143
87MP0002163_abnormal_gland_morphology0.46846147
88MP0000367_abnormal_coat/_hair0.46411804
89MP0000477_abnormal_intestine_morphology0.45162953
90MP0000647_abnormal_sebaceous_gland0.44300612
91MP0000015_abnormal_ear_pigmentation0.43055290
92MP0000609_abnormal_liver_physiology0.41001688
93MP0005381_digestive/alimentary_phenotyp0.40139616
94MP0002282_abnormal_trachea_morphology0.39883877
95MP0001340_abnormal_eyelid_morphology0.39761325
96MP0004381_abnormal_hair_follicle0.39674938
97MP0005636_abnormal_mineral_homeostasis0.38622975
98MP0002113_abnormal_skeleton_development0.38052905
99MP0001919_abnormal_reproductive_system0.37051648
100MP0005075_abnormal_melanosome_morpholog0.36557762

Predicted human phenotypes

RankGene SetZ-score
1Recurrent cutaneous fungal infections (HP:0011370)7.92020572
2Chronic mucocutaneous candidiasis (HP:0002728)7.92020572
3Cheilitis (HP:0100825)5.92829599
4Hemoptysis (HP:0002105)5.23733174
5Autoimmune hemolytic anemia (HP:0001890)5.00537539
6Recurrent fungal infections (HP:0002841)4.90175797
7Periodontitis (HP:0000704)4.78101032
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.54992924
9Abnormality of T cell number (HP:0011839)4.53168161
10Keratoconjunctivitis sicca (HP:0001097)4.46566545
11T lymphocytopenia (HP:0005403)4.44851523
12Keratoconjunctivitis (HP:0001096)4.38897967
13Abnormality of T cells (HP:0002843)4.36464776
14Severe combined immunodeficiency (HP:0004430)4.29890043
15Autoimmune thrombocytopenia (HP:0001973)4.19187416
16Increased IgM level (HP:0003496)4.18575283
17Premature loss of primary teeth (HP:0006323)4.12690831
18Abnormality of T cell physiology (HP:0011840)4.07120487
19IgG deficiency (HP:0004315)4.01195190
20Stomatitis (HP:0010280)3.98981184
21Median cleft lip (HP:0000161)3.97970755
22Increased hepatocellular lipid droplets (HP:0006565)3.94676320
23Optic neuritis (HP:0100653)3.90037838
24Retrobulbar optic neuritis (HP:0100654)3.90037838
25Pulmonary infiltrates (HP:0002113)3.89377531
26Panhypogammaglobulinemia (HP:0003139)3.75996882
27Lipid accumulation in hepatocytes (HP:0006561)3.74994755
28Orchitis (HP:0100796)3.60394282
29IgA deficiency (HP:0002720)3.43716853
30Combined immunodeficiency (HP:0005387)3.38353938
31Myositis (HP:0100614)3.24651869
32Xerostomia (HP:0000217)3.23789147
33Abnormality of eosinophils (HP:0001879)3.07840802
34Renal Fanconi syndrome (HP:0001994)3.05095146
35Encephalitis (HP:0002383)2.98658815
3611 pairs of ribs (HP:0000878)2.84665189
37Mesomelia (HP:0003027)2.84138920
38Malignant hyperthermia (HP:0002047)2.82913501
39Thyroiditis (HP:0100646)2.81562640
40Recurrent skin infections (HP:0001581)2.77923379
41Joint swelling (HP:0001386)2.74005324
42Recurrent viral infections (HP:0004429)2.72403850
43Long clavicles (HP:0000890)2.70105012
44Spinal cord lesions (HP:0100561)2.68426061
45Syringomyelia (HP:0003396)2.68426061
46Exertional dyspnea (HP:0002875)2.67919070
47Abnormality of the endocardium (HP:0004306)2.65580032
48Vasculitis (HP:0002633)2.59496733
49Granulocytopenia (HP:0001913)2.55153370
50Nonimmune hydrops fetalis (HP:0001790)2.50927790
51IgM deficiency (HP:0002850)2.49855518
52Skin rash (HP:0000988)2.48995765
53Abnormality of the pleura (HP:0002103)2.48117920
54Metaphyseal cupping (HP:0003021)2.45696379
55Abnormality of primary teeth (HP:0006481)2.43365048
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.40390785
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39839837
58Chronic diarrhea (HP:0002028)2.37605944
59Elevated erythrocyte sedimentation rate (HP:0003565)2.37492200
60Keratitis (HP:0000491)2.35294987
61Eosinophilia (HP:0001880)2.34060138
62Lymphopenia (HP:0001888)2.33790705
63Respiratory difficulties (HP:0002880)2.33199043
64Gangrene (HP:0100758)2.31796296
65Increased intramyocellular lipid droplets (HP:0012240)2.31702199
66Meningitis (HP:0001287)2.28659798
67Leukocytosis (HP:0001974)2.27972127
68Hypoproteinemia (HP:0003075)2.18612187
69Loss of speech (HP:0002371)2.18522849
70Abnormal foot bone ossification (HP:0010675)2.18149272
71Abnormality of the prostate (HP:0008775)2.17609949
72Recurrent bronchitis (HP:0002837)2.15453283
73Lower limb hyperreflexia (HP:0002395)2.14006158
74Hepatosplenomegaly (HP:0001433)2.12885721
75Pulmonary fibrosis (HP:0002206)2.12875916
76Pancreatic islet-cell hyperplasia (HP:0004510)2.09002557
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08770373
78Short 4th metacarpal (HP:0010044)2.08770373
79Arterial thrombosis (HP:0004420)2.08536258
80Gastrointestinal infarctions (HP:0005244)2.07362168
81Conical tooth (HP:0000698)2.06972815
82Postaxial foot polydactyly (HP:0001830)2.06098388
83Pruritus (HP:0000989)2.05602549
84Increased muscle lipid content (HP:0009058)2.04663767
85Neutropenia (HP:0001875)2.03819509
86Chronic otitis media (HP:0000389)2.03401050
87Pulmonary embolism (HP:0002204)1.96388097
88Anhidrosis (HP:0000970)1.95506210
89Acrocyanosis (HP:0001063)1.94820454
90Polyneuropathy (HP:0001271)1.94589588
91Brittle hair (HP:0002299)1.93775375
92Abnormality of B cell number (HP:0010975)1.89043741
93Glomerulopathy (HP:0100820)1.84558038
94Toxemia of pregnancy (HP:0100603)1.84415161
95Limb hypertonia (HP:0002509)1.81158422
96Chest pain (HP:0100749)1.79707616
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79125628
98Absent frontal sinuses (HP:0002688)1.79035281
99Porencephaly (HP:0002132)1.75796433
100Hypergammaglobulinemia (HP:0010702)1.75007010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.05935527
2NEK15.59740456
3MAP3K144.71091303
4STK393.75794442
5IKBKE3.27098849
6WNK43.19688791
7JAK13.02919767
8ACVR1B3.00136732
9JAK32.71820984
10CLK12.58215817
11IKBKB2.36962835
12TYK22.36459513
13MAP4K12.10847474
14TBK11.91804091
15TLK11.82593967
16LCK1.61260225
17KIT1.58665436
18OXSR11.58653891
19FGFR41.54786329
20EIF2AK21.51582870
21CDK41.42933785
22GRK61.40560486
23TAOK31.38618408
24FGFR31.33445233
25CSF1R1.30424502
26CHUK1.20209206
27MAP2K21.10754488
28PRKCH1.10109675
29MAP2K61.08959225
30PHKG21.03541160
31PHKG11.03541160
32MST41.01169203
33MAPK110.97807376
34CDK70.95941706
35PRKCQ0.89033661
36TNK20.87303903
37RPS6KB10.81606004
38BMPR20.80233965
39TTK0.77394209
40WNK10.73487116
41CSK0.73394012
42MAP3K130.69952399
43VRK10.66092543
44EPHA30.65862468
45BCR0.65569323
46NEK60.65004595
47TSSK60.64826850
48ATR0.64700718
49ITK0.63201603
50TIE10.62226999
51RPS6KA60.61256901
52FES0.60357862
53RPS6KC10.60269141
54RPS6KL10.60269141
55MAP3K120.60146862
56JAK20.58885848
57MAPK30.58314654
58SGK30.56021068
59HIPK20.55385680
60HCK0.55056752
61STK100.54700513
62ADRBK20.54535613
63SYK0.54432793
64STK40.53570877
65PAK30.52236403
66ZAK0.52074706
67LYN0.51246824
68PIM10.50389210
69IGF1R0.49223945
70MAP3K30.48288075
71NEK90.46909737
72SGK20.46863626
73NUAK10.46077720
74PRPF4B0.45311447
75BCKDK0.43978822
76SIK10.43597132
77INSR0.43273659
78MAP2K30.41584202
79MAPKAPK30.40878482
80KDR0.40208043
81CHEK10.36430172
82ILK0.36294090
83PRKG20.36074493
84TEC0.35650080
85PIK3CG0.35057552
86NLK0.34987609
87MAP3K40.34491953
88SGK10.34039380
89TRPM70.33561620
90EGFR0.31451149
91CDK60.29601437
92ZAP700.28753991
93MUSK0.28635683
94BTK0.28308437
95IRAK10.27876393
96PDK10.27567095
97FGFR10.23772890
98ABL10.22322372
99FYN0.20822556
100MAPK120.20820320

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002327.27758504
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053216.71553928
3Primary immunodeficiency_Homo sapiens_hsa053404.32176371
4Measles_Homo sapiens_hsa051622.97361610
5Autoimmune thyroid disease_Homo sapiens_hsa053202.87778538
6Allograft rejection_Homo sapiens_hsa053302.67992871
7* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.59485389
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.37244749
9Jak-STAT signaling pathway_Homo sapiens_hsa046302.28453356
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.28348598
11Graft-versus-host disease_Homo sapiens_hsa053322.13464675
12T cell receptor signaling pathway_Homo sapiens_hsa046602.12897769
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77854478
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74855060
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72027279
16Asthma_Homo sapiens_hsa053101.70287802
17Rheumatoid arthritis_Homo sapiens_hsa053231.60964923
18Leishmaniasis_Homo sapiens_hsa051401.60337982
19Type I diabetes mellitus_Homo sapiens_hsa049401.58052235
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.56492622
21Proteasome_Homo sapiens_hsa030501.44169049
22Hematopoietic cell lineage_Homo sapiens_hsa046401.29436535
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25469780
24TNF signaling pathway_Homo sapiens_hsa046681.24091459
25Antigen processing and presentation_Homo sapiens_hsa046121.23728572
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23130495
27Herpes simplex infection_Homo sapiens_hsa051681.21575922
28Osteoclast differentiation_Homo sapiens_hsa043801.20933223
29Toxoplasmosis_Homo sapiens_hsa051451.08463277
30Protein export_Homo sapiens_hsa030601.03192953
31Hepatitis C_Homo sapiens_hsa051601.02834033
32Influenza A_Homo sapiens_hsa051641.00148794
33Malaria_Homo sapiens_hsa051440.96367969
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96076628
35Chemokine signaling pathway_Homo sapiens_hsa040620.93863558
36B cell receptor signaling pathway_Homo sapiens_hsa046620.92724306
37Epstein-Barr virus infection_Homo sapiens_hsa051690.88725194
38HTLV-I infection_Homo sapiens_hsa051660.86312923
39Homologous recombination_Homo sapiens_hsa034400.78041781
40Apoptosis_Homo sapiens_hsa042100.70998646
41Hepatitis B_Homo sapiens_hsa051610.69707872
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68408274
43Pertussis_Homo sapiens_hsa051330.67001868
44Viral myocarditis_Homo sapiens_hsa054160.66134534
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.65098625
46Viral carcinogenesis_Homo sapiens_hsa052030.63451043
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56251565
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55217654
49Non-small cell lung cancer_Homo sapiens_hsa052230.53596956
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.53587421
51MAPK signaling pathway_Homo sapiens_hsa040100.53069760
52Nucleotide excision repair_Homo sapiens_hsa034200.53019794
53Shigellosis_Homo sapiens_hsa051310.51135096
54Tuberculosis_Homo sapiens_hsa051520.49918773
55Acute myeloid leukemia_Homo sapiens_hsa052210.49414216
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48878174
57Fanconi anemia pathway_Homo sapiens_hsa034600.48720380
58Phototransduction_Homo sapiens_hsa047440.47861515
59Inositol phosphate metabolism_Homo sapiens_hsa005620.47855939
60Small cell lung cancer_Homo sapiens_hsa052220.46559924
61Prolactin signaling pathway_Homo sapiens_hsa049170.43373703
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.38893928
63Endocytosis_Homo sapiens_hsa041440.37827844
64Dorso-ventral axis formation_Homo sapiens_hsa043200.37100068
65RNA degradation_Homo sapiens_hsa030180.36956942
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32532159
67Legionellosis_Homo sapiens_hsa051340.30914149
68mRNA surveillance pathway_Homo sapiens_hsa030150.29721324
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28976140
70Arachidonic acid metabolism_Homo sapiens_hsa005900.28678686
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28029093
72RNA polymerase_Homo sapiens_hsa030200.27700010
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26613370
74Mismatch repair_Homo sapiens_hsa034300.24559206
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23395728
76DNA replication_Homo sapiens_hsa030300.22463937
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22179995
78Propanoate metabolism_Homo sapiens_hsa006400.21693004
79African trypanosomiasis_Homo sapiens_hsa051430.21133084
80Basal transcription factors_Homo sapiens_hsa030220.21012500
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20646968
82Olfactory transduction_Homo sapiens_hsa047400.18846086
83FoxO signaling pathway_Homo sapiens_hsa040680.17700684
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15898742
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15770601
86Nitrogen metabolism_Homo sapiens_hsa009100.14086943
87One carbon pool by folate_Homo sapiens_hsa006700.13798417
88Insulin resistance_Homo sapiens_hsa049310.12687159
89Purine metabolism_Homo sapiens_hsa002300.10552287
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09332586
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08162671
92Spliceosome_Homo sapiens_hsa030400.07747088
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06408657
94Chemical carcinogenesis_Homo sapiens_hsa052040.05578798
95Staphylococcus aureus infection_Homo sapiens_hsa051500.05411376
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.03689045
97Chronic myeloid leukemia_Homo sapiens_hsa052200.02918411
98Circadian rhythm_Homo sapiens_hsa047100.02794754
99Platelet activation_Homo sapiens_hsa046110.02740876
100Systemic lupus erythematosus_Homo sapiens_hsa053220.00674251

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