IL27RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.74730773
2negative T cell selection (GO:0043383)7.43465326
3negative thymic T cell selection (GO:0045060)7.27671633
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.96143752
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.96143752
6positive thymic T cell selection (GO:0045059)6.59667175
7regulation of gamma-delta T cell differentiation (GO:0045586)6.49687171
8negative regulation of cell killing (GO:0031342)6.48179230
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.48179230
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.46948998
11thymic T cell selection (GO:0045061)6.12104368
12antigen processing and presentation of endogenous antigen (GO:0019883)6.04287037
13positive T cell selection (GO:0043368)5.98525322
14response to interleukin-15 (GO:0070672)5.98067526
15regulation of gamma-delta T cell activation (GO:0046643)5.87222612
16cellular response to interleukin-15 (GO:0071350)5.76308117
17T cell selection (GO:0045058)5.69690148
18interferon-gamma production (GO:0032609)5.39523658
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.36949334
20regulation of T cell tolerance induction (GO:0002664)5.31811999
21leukocyte aggregation (GO:0070486)5.31129190
22T cell migration (GO:0072678)5.30836798
23T cell receptor signaling pathway (GO:0050852)5.03874885
24* regulation of isotype switching to IgG isotypes (GO:0048302)4.89378997
25regulation of B cell receptor signaling pathway (GO:0050855)4.73623795
26T cell costimulation (GO:0031295)4.73534795
27positive regulation of tolerance induction (GO:0002645)4.71580849
28lymphocyte costimulation (GO:0031294)4.70097772
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51597347
30antigen receptor-mediated signaling pathway (GO:0050851)4.46232215
31regulation of regulatory T cell differentiation (GO:0045589)4.45967166
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38812943
33positive regulation by organism of defense response of other organism involved in symbiotic interact4.38812943
34modulation by symbiont of host immune response (GO:0052553)4.38812943
35positive regulation by symbiont of host defense response (GO:0052509)4.38812943
36modulation by symbiont of host defense response (GO:0052031)4.38812943
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38812943
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.37494594
39regulation of alpha-beta T cell proliferation (GO:0046640)4.30208851
40regulation of T cell receptor signaling pathway (GO:0050856)4.24148647
41tolerance induction (GO:0002507)4.22784913
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.21364916
43regulation of tolerance induction (GO:0002643)4.13216522
44regulation of interleukin-2 biosynthetic process (GO:0045076)4.10620664
45positive regulation of alpha-beta T cell proliferation (GO:0046641)4.02620941
46positive regulation of isotype switching (GO:0045830)3.92376464
47positive regulation of interleukin-2 production (GO:0032743)3.85148220
48antigen processing and presentation via MHC class Ib (GO:0002475)3.82045441
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.79980984
50mast cell activation (GO:0045576)3.77539589
51immunoglobulin mediated immune response (GO:0016064)3.77098631
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.74503263
53ribosomal small subunit assembly (GO:0000028)3.70996341
54detection of bacterium (GO:0016045)3.68722901
55regulation of B cell differentiation (GO:0045577)3.65168007
56regulation of response to interferon-gamma (GO:0060330)3.64389633
57negative regulation of T cell mediated immunity (GO:0002710)3.64147840
58regulation of natural killer cell mediated immunity (GO:0002715)3.62714022
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.62714022
60positive regulation of natural killer cell mediated immunity (GO:0002717)3.60748726
61positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.60748726
62detection of other organism (GO:0098543)3.60187017
63regulation of interferon-beta biosynthetic process (GO:0045357)3.60126184
64regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.59401923
65sequestering of actin monomers (GO:0042989)3.57164725
66neutrophil activation involved in immune response (GO:0002283)3.55132045
67T cell homeostasis (GO:0043029)3.54627023
68B cell receptor signaling pathway (GO:0050853)3.54061517
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.53836294
70negative regulation of leukocyte mediated immunity (GO:0002704)3.51845963
71activated T cell proliferation (GO:0050798)3.51327940
72T cell differentiation (GO:0030217)3.50822600
73macrophage activation involved in immune response (GO:0002281)3.48843998
74cellular extravasation (GO:0045123)3.47208259
75negative regulation of interleukin-12 production (GO:0032695)3.46127973
76regulation of type I interferon-mediated signaling pathway (GO:0060338)3.44156810
77positive regulation of DNA recombination (GO:0045911)3.38648879
78positive regulation of granulocyte differentiation (GO:0030854)3.38564581
79B cell mediated immunity (GO:0019724)3.38030153
80positive regulation of humoral immune response (GO:0002922)3.38005916
81positive regulation of immunoglobulin mediated immune response (GO:0002891)3.37946222
82positive regulation of B cell mediated immunity (GO:0002714)3.37946222
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.37645296
84leukocyte cell-cell adhesion (GO:0007159)3.36778959
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.34929668
86alpha-beta T cell activation (GO:0046631)3.33425686
87positive regulation of immunoglobulin production (GO:0002639)3.27538170
88NIK/NF-kappaB signaling (GO:0038061)3.27140212
89natural killer cell activation (GO:0030101)3.23846441
90T cell activation (GO:0042110)3.22027862
91alpha-beta T cell differentiation (GO:0046632)3.20623114
92negative regulation of lymphocyte mediated immunity (GO:0002707)3.19118546
93response to type I interferon (GO:0034340)3.18759192
94respiratory burst (GO:0045730)3.18147826
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.18026348
96response to host immune response (GO:0052572)3.15718070
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15718070
98negative regulation of T cell receptor signaling pathway (GO:0050860)3.15284445
99regulation of T cell mediated cytotoxicity (GO:0001914)3.15270035
100negative regulation of phagocytosis (GO:0050765)3.14172310
101immune response-activating cell surface receptor signaling pathway (GO:0002429)3.13758098
102viral transcription (GO:0019083)3.13464714
103* regulation of isotype switching (GO:0045191)3.13230499
104myeloid cell activation involved in immune response (GO:0002275)3.12951517
105response to muramyl dipeptide (GO:0032495)3.12320155
106negative regulation of innate immune response (GO:0045824)3.12166322
107cellular response to type I interferon (GO:0071357)3.11992733
108type I interferon signaling pathway (GO:0060337)3.11992733
109regulation of defense response to virus by virus (GO:0050690)3.10812619
110CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.09210585
111mast cell activation involved in immune response (GO:0002279)3.07773545
112mast cell degranulation (GO:0043303)3.07773545
113leukocyte degranulation (GO:0043299)3.07494365
114response to peptidoglycan (GO:0032494)3.06349863
115interferon-gamma-mediated signaling pathway (GO:0060333)3.05957318
116regulation of cell killing (GO:0031341)3.05757671
117lymphocyte homeostasis (GO:0002260)3.04595072
118lymphocyte migration (GO:0072676)3.03164310
119regulation of interleukin-2 production (GO:0032663)3.01585331
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.01504656
121lymph node development (GO:0048535)3.01219119
122positive regulation of B cell differentiation (GO:0045579)3.00641218
123* regulation of immunoglobulin mediated immune response (GO:0002889)3.00398364
124negative regulation of erythrocyte differentiation (GO:0045647)3.00283804
125B cell homeostasis (GO:0001782)2.99259916
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98555927
127positive regulation of cell killing (GO:0031343)2.98327145
128translational termination (GO:0006415)2.97839134
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96875673
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92939491
131response to host (GO:0075136)2.92939491
132response to host defenses (GO:0052200)2.92939491
133negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88590988
134neutrophil activation (GO:0042119)2.84462196
135regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.82276922
136regulation of alpha-beta T cell activation (GO:0046634)2.81079513
137regulation of T cell mediated immunity (GO:0002709)2.80790914
138defense response to protozoan (GO:0042832)2.80730465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.73830928
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.53076368
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.18962535
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.90915410
5MYC_22102868_ChIP-Seq_BL_Human3.51812114
6RUNX_20019798_ChIP-Seq_JUKART_Human3.40775205
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.28569144
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27601613
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.26545110
10E2F7_22180533_ChIP-Seq_HELA_Human3.25630998
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22854469
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.20401895
13MYB_26560356_Chip-Seq_TH2_Human3.03976694
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94737548
15MAF_26560356_Chip-Seq_TH1_Human2.83267103
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69166754
17MYB_26560356_Chip-Seq_TH1_Human2.63733479
18UTX_26944678_Chip-Seq_JUKART_Human2.61053174
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.57372353
20SCL_19346495_ChIP-Seq_HPC-7_Human2.56037123
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.53815043
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37896182
23VDR_21846776_ChIP-Seq_THP-1_Human2.36626716
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.33765827
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10614120
26SPI1_23547873_ChIP-Seq_NB4_Human2.06091277
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.05287626
28* MAF_26560356_Chip-Seq_TH2_Human2.02319956
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.99025603
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98328459
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89813748
32TCF7_22412390_ChIP-Seq_EML_Mouse1.88747537
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87679501
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87109537
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87086825
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84869639
37GATA3_27048872_Chip-Seq_THYMUS_Human1.84549407
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82974572
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82690094
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82013184
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74291194
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.72890416
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.72189166
44VDR_24763502_ChIP-Seq_THP-1_Human1.69256676
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65342583
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56388638
47CIITA_25753668_ChIP-Seq_RAJI_Human1.53649557
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52814788
49KDM2B_26808549_Chip-Seq_DND41_Human1.44652963
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44119268
51VDR_23849224_ChIP-Seq_CD4+_Human1.40692191
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39263758
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38104659
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37219282
55SPI1_23127762_ChIP-Seq_K562_Human1.36866973
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30212987
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29237093
58FOXP3_21729870_ChIP-Seq_TREG_Human1.29004730
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26055402
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23600492
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19649611
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19601355
63GATA3_26560356_Chip-Seq_TH2_Human1.18335719
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16317755
65PU_27001747_Chip-Seq_BMDM_Mouse1.16188886
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16011384
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15955671
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.15742894
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14048045
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.11916311
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11098986
72LXR_22292898_ChIP-Seq_THP-1_Human1.11005435
73BCOR_27268052_Chip-Seq_Bcells_Human1.10603824
74* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08556746
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06310295
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05684320
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.03968825
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03783217
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02009450
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01696816
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99642363
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97528853
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95869927
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.95100112
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93064268
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.92231951
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92153425
88P300_27268052_Chip-Seq_Bcells_Human0.91810760
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91131488
90P68_20966046_ChIP-Seq_HELA_Human0.91048142
91TFEB_21752829_ChIP-Seq_HELA_Human0.90885319
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90825069
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90752373
94XRN2_22483619_ChIP-Seq_HELA_Human0.90528881
95GATA1_22025678_ChIP-Seq_K562_Human0.90306564
96GABP_17652178_ChIP-ChIP_JURKAT_Human0.89650512
97VDR_24787735_ChIP-Seq_THP-1_Human0.89295750
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89155012
99SPI1_20517297_ChIP-Seq_HL60_Human0.88555979
100GATA1_19941826_ChIP-Seq_K562_Human0.87769036
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87438453
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86291020
103ELK1_19687146_ChIP-ChIP_HELA_Human0.85975457
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85483987
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84582753
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82822613
107EST1_17652178_ChIP-ChIP_JURKAT_Human0.81144544
108* NCOR1_26117541_ChIP-Seq_K562_Human0.79927186
109MYC_19079543_ChIP-ChIP_MESCs_Mouse0.77070393
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.76634737
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75256259
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.73584734
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72481654
114BCL6_27268052_Chip-Seq_Bcells_Human0.70759654
115SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.70401336
116RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67951302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.55405446
2MP0005671_abnormal_response_to4.52353535
3MP0000685_abnormal_immune_system3.80103527
4MP0001835_abnormal_antigen_presentation3.66729935
5MP0001800_abnormal_humoral_immune3.33993361
6MP0005387_immune_system_phenotype3.07690226
7MP0001790_abnormal_immune_system3.07690226
8* MP0002420_abnormal_adaptive_immunity2.92208890
9* MP0002398_abnormal_bone_marrow2.92072858
10MP0005000_abnormal_immune_tolerance2.91581728
11MP0002166_altered_tumor_susceptibility2.88748603
12MP0002396_abnormal_hematopoietic_system2.88273376
13* MP0001819_abnormal_immune_cell2.87365549
14MP0009785_altered_susceptibility_to2.85370791
15* MP0002723_abnormal_immune_serum2.84121949
16MP0009333_abnormal_splenocyte_physiolog2.77128719
17MP0002452_abnormal_antigen_presenting2.72981268
18MP0001873_stomach_inflammation2.66417043
19MP0000703_abnormal_thymus_morphology2.55623948
20* MP0000716_abnormal_immune_system2.52378314
21* MP0005025_abnormal_response_to2.50213098
22MP0002405_respiratory_system_inflammati2.45434936
23MP0002722_abnormal_immune_system2.43282959
24MP0000689_abnormal_spleen_morphology2.38916922
25MP0003724_increased_susceptibility_to2.37516969
26MP0003436_decreased_susceptibility_to2.37055092
27MP0002006_tumorigenesis2.29134403
28MP0003866_abnormal_defecation2.23870396
29MP0006082_CNS_inflammation2.19611659
30MP0010155_abnormal_intestine_physiology2.19181109
31* MP0002429_abnormal_blood_cell2.10126794
32MP0004947_skin_inflammation2.03967795
33MP0002148_abnormal_hypersensitivity_rea1.98292291
34MP0002419_abnormal_innate_immunity1.94456535
35MP0005464_abnormal_platelet_physiology1.90051877
36MP0003300_gastrointestinal_ulcer1.88576690
37MP0002933_joint_inflammation1.88140370
38MP0004808_abnormal_hematopoietic_stem1.84932937
39MP0001845_abnormal_inflammatory_respons1.71522710
40MP0001853_heart_inflammation1.66477803
41MP0000465_gastrointestinal_hemorrhage1.56436582
42MP0004510_myositis1.55992028
43MP0003303_peritoneal_inflammation1.51786670
44MP0001545_abnormal_hematopoietic_system1.39779612
45MP0005397_hematopoietic_system_phenotyp1.39779612
46MP0000858_altered_metastatic_potential1.35677258
47MP0003172_abnormal_lysosome_physiology1.33186966
48MP0000490_abnormal_crypts_of1.33183035
49MP0005075_abnormal_melanosome_morpholog1.32672267
50MP0005310_abnormal_salivary_gland1.22379792
51MP0008260_abnormal_autophagy1.21229509
52MP0008469_abnormal_protein_level1.20645946
53MP0003191_abnormal_cellular_cholesterol1.19067536
54MP0002019_abnormal_tumor_incidence1.10780458
55MP0004381_abnormal_hair_follicle1.08285170
56MP0005058_abnormal_lysosome_morphology1.05394572
57MP0003806_abnormal_nucleotide_metabolis1.04446392
58MP0001851_eye_inflammation1.03290666
59MP0003448_altered_tumor_morphology1.01382321
60MP0001533_abnormal_skeleton_physiology1.00417447
61MP0005451_abnormal_body_composition0.95929612
62MP0005174_abnormal_tail_pigmentation0.95629116
63MP0010352_gastrointestinal_tract_polyps0.93786350
64MP0002009_preneoplasia0.93074323
65MP0003183_abnormal_peptide_metabolism0.92091046
66MP0002132_abnormal_respiratory_system0.90604410
67MP0009840_abnormal_foam_cell0.87820454
68MP0002277_abnormal_respiratory_mucosa0.87206322
69MP0008057_abnormal_DNA_replication0.85288619
70MP0009278_abnormal_bone_marrow0.85052245
71MP0005023_abnormal_wound_healing0.84880408
72MP0002138_abnormal_hepatobiliary_system0.83945904
73MP0002254_reproductive_system_inflammat0.83782038
74MP0003828_pulmonary_edema0.82679229
75MP0003077_abnormal_cell_cycle0.79966284
76MP0002998_abnormal_bone_remodeling0.78187957
77MP0009763_increased_sensitivity_to0.74149686
78MP0009765_abnormal_xenobiotic_induced0.70226776
79MP0009764_decreased_sensitivity_to0.67460905
80MP0000477_abnormal_intestine_morphology0.66678262
81MP0003045_fibrosis0.66243074
82MP0008007_abnormal_cellular_replicative0.65480834
83MP0000604_amyloidosis0.65356903
84MP0002095_abnormal_skin_pigmentation0.62216362
85MP0005390_skeleton_phenotype0.62146975
86MP0008961_abnormal_basal_metabolism0.61785894
87MP0004883_abnormal_blood_vessel0.61146300
88MP0003075_altered_response_to0.61113462
89MP0001663_abnormal_digestive_system0.58815744
90MP0003656_abnormal_erythrocyte_physiolo0.55962168
91MP0004782_abnormal_surfactant_physiolog0.55229396
92MP0001348_abnormal_lacrimal_gland0.54972382
93MP0003943_abnormal_hepatobiliary_system0.54879093
94MP0008058_abnormal_DNA_repair0.54193790
95MP0000313_abnormal_cell_death0.54109033
96MP0000609_abnormal_liver_physiology0.53182439
97MP0010094_abnormal_chromosome_stability0.52466393
98MP0001191_abnormal_skin_condition0.51289645
99MP0002877_abnormal_melanocyte_morpholog0.50991823
100MP0003795_abnormal_bone_structure0.50889747
101MP0002163_abnormal_gland_morphology0.50755626
102MP0002136_abnormal_kidney_physiology0.50492367
103MP0004957_abnormal_blastocyst_morpholog0.50485096
104MP0003693_abnormal_embryo_hatching0.50206536
105MP0006054_spinal_hemorrhage0.48276483
106MP0001986_abnormal_taste_sensitivity0.47307787
107MP0008874_decreased_physiological_sensi0.47213289
108MP0000015_abnormal_ear_pigmentation0.46946453
109MP0000249_abnormal_blood_vessel0.46609099
110MP0005381_digestive/alimentary_phenotyp0.45575852
111MP0003453_abnormal_keratinocyte_physiol0.45526425
112MP0008873_increased_physiological_sensi0.44217497
113MP0000598_abnormal_liver_morphology0.43236589
114MP0002332_abnormal_exercise_endurance0.43105457
115MP0010234_abnormal_vibrissa_follicle0.40992152
116MP0000343_altered_response_to0.40106031
117MP0002083_premature_death0.37181751
118MP0002693_abnormal_pancreas_physiology0.36362721
119MP0001243_abnormal_dermal_layer0.35376651
120MP0001216_abnormal_epidermal_layer0.34398505
121MP0000367_abnormal_coat/_hair0.34380316
122MP0009379_abnormal_foot_pigmentation0.34171852
123MP0005166_decreased_susceptibility_to0.34116740

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.95505102
2Abnormality of T cell number (HP:0011839)6.64366752
3Elevated erythrocyte sedimentation rate (HP:0003565)5.67527903
4Recurrent bronchitis (HP:0002837)5.35463019
5Abnormality of T cells (HP:0002843)5.33578817
6IgM deficiency (HP:0002850)5.03138365
7Severe combined immunodeficiency (HP:0004430)4.98681697
8Chronic otitis media (HP:0000389)4.81596654
9Combined immunodeficiency (HP:0005387)4.73178042
10Abnormality of macrophages (HP:0004311)4.52953150
11Nasal polyposis (HP:0100582)4.44837091
12Recurrent fungal infections (HP:0002841)4.43773865
13Stomatitis (HP:0010280)4.43234086
14Recurrent viral infections (HP:0004429)4.40329348
15Panhypogammaglobulinemia (HP:0003139)4.39235887
16Myositis (HP:0100614)4.36178058
17IgG deficiency (HP:0004315)4.32525935
18Chronic mucocutaneous candidiasis (HP:0002728)4.09889011
19Recurrent cutaneous fungal infections (HP:0011370)4.09889011
20Abnormality of the nasal mucosa (HP:0000433)4.00507392
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.90789458
22Pustule (HP:0200039)3.83181330
23Abnormality of T cell physiology (HP:0011840)3.81930117
24Lymphopenia (HP:0001888)3.80065784
25Autoimmune hemolytic anemia (HP:0001890)3.73910878
26Abnormality of cells of the lymphoid lineage (HP:0012140)3.64322746
27Chronic diarrhea (HP:0002028)3.62988054
28Eczematoid dermatitis (HP:0000976)3.55560367
29Abnormality of the fingertips (HP:0001211)3.50988323
30Abnormality of eosinophils (HP:0001879)3.43681925
31Thyroiditis (HP:0100646)3.43238279
32Thrombocytosis (HP:0001894)3.40381114
33Agammaglobulinemia (HP:0004432)3.33885107
34B lymphocytopenia (HP:0010976)3.30854951
35Abnormality of B cell number (HP:0010975)3.30854951
36Recurrent gram-negative bacterial infections (HP:0005420)3.21643010
37Leukocytosis (HP:0001974)3.17722576
38Meningitis (HP:0001287)3.15132804
39Autoimmune thrombocytopenia (HP:0001973)3.14430146
40Spontaneous hematomas (HP:0007420)3.12125677
41Joint swelling (HP:0001386)3.06496752
42Recurrent sinusitis (HP:0011108)3.05756509
43Increased IgM level (HP:0003496)3.04555394
44Vasculitis (HP:0002633)3.03424906
45Hypoplasia of the thymus (HP:0000778)3.00850507
46Bronchitis (HP:0012387)3.00208808
47Eosinophilia (HP:0001880)2.94493300
48Orchitis (HP:0100796)2.93857618
49Urticaria (HP:0001025)2.92054711
50Optic neuritis (HP:0100653)2.90654757
51Retrobulbar optic neuritis (HP:0100654)2.90654757
52Basal cell carcinoma (HP:0002671)2.90482725
53Inflammation of the large intestine (HP:0002037)2.90129412
54Hemoptysis (HP:0002105)2.87110519
55Gastrointestinal inflammation (HP:0004386)2.85357763
56Recurrent abscess formation (HP:0002722)2.83961502
57Granulocytopenia (HP:0001913)2.81783711
58IgA deficiency (HP:0002720)2.81542525
59Lymphoma (HP:0002665)2.80244083
60Prolonged bleeding time (HP:0003010)2.78906636
61Encephalitis (HP:0002383)2.76295937
62Epistaxis (HP:0000421)2.75190526
63Hypochromic anemia (HP:0001931)2.74097358
64Recurrent skin infections (HP:0001581)2.72071175
65Mediastinal lymphadenopathy (HP:0100721)2.69438110
66Pulmonary infiltrates (HP:0002113)2.65743656
67Chronic sinusitis (HP:0011109)2.58848472
68Papilloma (HP:0012740)2.51752665
69Verrucae (HP:0200043)2.51752665
70Hypergammaglobulinemia (HP:0010702)2.49706102
71Petechiae (HP:0000967)2.47229922
72Anorexia (HP:0002039)2.47033241
73Gingivitis (HP:0000230)2.46520272
74Increased IgE level (HP:0003212)2.41665143
75Gastrointestinal infarctions (HP:0005244)2.40830733
76Obstructive lung disease (HP:0006536)2.40234371
77Chronic obstructive pulmonary disease (HP:0006510)2.40234371
78Chest pain (HP:0100749)2.35422452
79Arterial thrombosis (HP:0004420)2.31447161
80Abnormality of cells of the erythroid lineage (HP:0012130)2.29444121
81Stomach cancer (HP:0012126)2.28397730
82Abnormality of liposaccharide metabolism (HP:0010968)2.26783198
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.26783198
84Abnormality of glycolipid metabolism (HP:0010969)2.26783198
85Osteomyelitis (HP:0002754)2.25831571
86Recurrent otitis media (HP:0000403)2.24962918
87Abnormal number of erythroid precursors (HP:0012131)2.23967662
88Gastrointestinal stroma tumor (HP:0100723)2.23730094
89Pulmonary embolism (HP:0002204)2.22604998
90Gingival bleeding (HP:0000225)2.21048450
91Keratoconjunctivitis sicca (HP:0001097)2.20052841
92Fatigue (HP:0012378)2.18881874
93Poikiloderma (HP:0001029)2.16769925
94Abnormality of the prostate (HP:0008775)2.15863180
95Microcytic anemia (HP:0001935)2.14532356
96Recurrent bacterial skin infections (HP:0005406)2.10102944
97Abnormal platelet volume (HP:0011876)2.09860271
98Keratitis (HP:0000491)2.09490843
99Colitis (HP:0002583)2.06437181
100Gangrene (HP:0100758)2.04711367
101Cheilitis (HP:0100825)2.03488937
102Amaurosis fugax (HP:0100576)2.03460145
103Increased serum ferritin (HP:0003281)2.02488780
104Vacuolated lymphocytes (HP:0001922)2.01854696
105Increased cerebral lipofuscin (HP:0011813)2.01604517
106Skin rash (HP:0000988)2.01410839
107Sepsis (HP:0100806)2.00811964
108Emphysema (HP:0002097)2.00643111
109Cellulitis (HP:0100658)1.99632460
110Aplastic anemia (HP:0001915)1.99271107
111Episodic fever (HP:0001954)1.98760459
112Keratoconjunctivitis (HP:0001096)1.98024701
113Hepatosplenomegaly (HP:0001433)1.96524980
114Abnormality of the pleura (HP:0002103)1.95772443
115Acute hepatic failure (HP:0006554)1.94661071
116Abnormal platelet function (HP:0011869)1.94125095
117Impaired platelet aggregation (HP:0003540)1.94125095
118Glomerulopathy (HP:0100820)1.93461763
119Hepatitis (HP:0012115)1.92990456
120Viral hepatitis (HP:0006562)1.91753888
121Reticulocytopenia (HP:0001896)1.90432638
122Aplasia/Hypoplasia of the thymus (HP:0010515)1.88093332
123Skin ulcer (HP:0200042)1.87564429
124Ureteral stenosis (HP:0000071)1.87124484
125Bronchiectasis (HP:0002110)1.83300120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.02320013
2TXK5.78849493
3RIPK43.66884085
4JAK33.16719751
5ZAP703.11672729
6ITK2.97392053
7FGFR42.93489150
8IKBKE2.76683043
9TYK22.70000808
10STK102.51724180
11PRPF4B2.46568165
12GRK62.18793787
13NLK2.07785317
14NME21.99538697
15JAK11.99086861
16LCK1.97399035
17TEC1.92939612
18FGFR31.82128832
19KIT1.80431885
20TBK11.76500300
21BTK1.76113286
22KDR1.75956836
23MAP3K141.69019886
24SYK1.64011038
25MAP3K131.60064622
26MAP3K111.56451764
27EEF2K1.50764579
28CSK1.44454260
29HCK1.38097067
30MAP3K101.33309541
31TGFBR21.28620379
32LRRK21.25306501
33IRAK41.22881952
34BLK1.22661935
35SIK21.18137069
36IKBKB1.18072554
37SMG11.16719322
38TLK11.16545441
39MAP3K31.13388464
40PRKCQ1.10802982
41PKN21.09637321
42TESK21.08853431
43MARK31.05359145
44MST41.03252762
45TNK21.03132170
46FGR1.01605437
47TGFBR11.00239090
48PRKCH0.99617539
49MAP3K10.96508004
50PIM10.95638893
51BMPR20.95341547
52CLK10.93909052
53CSF1R0.93341056
54LYN0.90725846
55FES0.90170341
56TAOK20.89898902
57SIK30.88320954
58MAP3K120.86767897
59JAK20.84764040
60RPS6KA40.82239296
61FLT30.79083941
62MAP2K20.78671915
63ERN10.78438606
64MATK0.76071404
65MAP3K70.75598366
66MAP2K30.74600013
67CHUK0.68512684
68CDK40.59993464
69TRIB30.59755181
70CAMKK20.59018790
71PASK0.58832373
72IRAK30.49906939
73CAMKK10.49390813
74MAP2K60.49114494
75PIK3CG0.48150111
76MARK20.48032771
77SRPK10.47426831
78HIPK20.46652312
79PRKD20.45217561
80MAPKAPK20.44314937
81PIM20.44182236
82PDGFRB0.43959721
83MAPK110.43583122
84PDK10.43479401
85MAPK70.40763218
86STK40.40453878
87ACVR1B0.40044524
88NEK90.39707321
89RPS6KL10.38834717
90RPS6KC10.38834717
91MAP3K80.37842926
92EPHA30.37656120
93TYRO30.37491733
94PDPK10.37079352
95IGF1R0.35620005
96PTK60.35254521
97FYN0.34790642
98INSR0.34254749
99TTN0.33537787
100IRAK10.33049217
101GRK70.32624051
102MAPK40.31340600
103SCYL20.30815528
104MAPK120.30520442
105TAOK10.30490116
106BCKDK0.30396048
107RPS6KB20.30222242
108EPHB10.29248337
109MAPK30.27731586
110RAF10.27079907
111MAP3K50.26967729
112TAOK30.26941375
113RPS6KA50.26753759
114CDK120.26251394
115RPS6KA60.25774498
116BRD40.25522457
117CDK90.25322471
118CDC42BPA0.24504524
119SIK10.24468169
120RPS6KA10.24158885
121CDK60.24113679
122MELK0.23842864
123KSR20.23496602
124ABL10.23192885
125ALK0.22651528
126TRPM70.22016736
127ATR0.21849255
128YES10.20118239
129TNIK0.19761382
130FGFR10.18577013
131STK240.18536084

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.97714176
2T cell receptor signaling pathway_Homo sapiens_hsa046603.66787328
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.12268820
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.99657621
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.93953149
6Measles_Homo sapiens_hsa051622.85697183
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.64382669
8Antigen processing and presentation_Homo sapiens_hsa046122.58221843
9Hematopoietic cell lineage_Homo sapiens_hsa046402.43167129
10Allograft rejection_Homo sapiens_hsa053302.40324213
11Graft-versus-host disease_Homo sapiens_hsa053322.12715794
12Ribosome_Homo sapiens_hsa030102.09838999
13B cell receptor signaling pathway_Homo sapiens_hsa046622.06199816
14Leishmaniasis_Homo sapiens_hsa051401.99037448
15Osteoclast differentiation_Homo sapiens_hsa043801.86812715
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80868044
17Viral myocarditis_Homo sapiens_hsa054161.78241183
18Herpes simplex infection_Homo sapiens_hsa051681.77908468
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77146292
20Autoimmune thyroid disease_Homo sapiens_hsa053201.74223294
21* Jak-STAT signaling pathway_Homo sapiens_hsa046301.71627337
22Acute myeloid leukemia_Homo sapiens_hsa052211.34133222
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31052969
24Hepatitis B_Homo sapiens_hsa051611.29247980
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28329804
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28108183
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.26315854
28DNA replication_Homo sapiens_hsa030301.25207609
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24160216
30Chemokine signaling pathway_Homo sapiens_hsa040621.23964932
31Toxoplasmosis_Homo sapiens_hsa051451.23647508
32Asthma_Homo sapiens_hsa053101.18774880
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18076736
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16291667
35Shigellosis_Homo sapiens_hsa051311.14614353
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12565340
37Influenza A_Homo sapiens_hsa051641.10842752
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06976179
39HTLV-I infection_Homo sapiens_hsa051661.06777380
40Spliceosome_Homo sapiens_hsa030401.06247712
41Platelet activation_Homo sapiens_hsa046111.02898231
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02240585
43Apoptosis_Homo sapiens_hsa042100.99423645
44TNF signaling pathway_Homo sapiens_hsa046680.95797797
45Mismatch repair_Homo sapiens_hsa034300.94942743
46Non-homologous end-joining_Homo sapiens_hsa034500.94135249
47Base excision repair_Homo sapiens_hsa034100.92708493
48Epstein-Barr virus infection_Homo sapiens_hsa051690.92314805
49Malaria_Homo sapiens_hsa051440.89464001
50Colorectal cancer_Homo sapiens_hsa052100.87838732
51Legionellosis_Homo sapiens_hsa051340.86580736
52Pancreatic cancer_Homo sapiens_hsa052120.86338915
53Hepatitis C_Homo sapiens_hsa051600.80989312
54Staphylococcus aureus infection_Homo sapiens_hsa051500.79399679
55Phagosome_Homo sapiens_hsa041450.78984993
56Chronic myeloid leukemia_Homo sapiens_hsa052200.78070087
57Viral carcinogenesis_Homo sapiens_hsa052030.77659595
58p53 signaling pathway_Homo sapiens_hsa041150.77076720
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75396990
60Prolactin signaling pathway_Homo sapiens_hsa049170.74060151
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71915611
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71062460
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71008713
64Lysosome_Homo sapiens_hsa041420.70423731
65Thyroid cancer_Homo sapiens_hsa052160.67106016
66VEGF signaling pathway_Homo sapiens_hsa043700.65703809
67Type I diabetes mellitus_Homo sapiens_hsa049400.65362234
68RNA degradation_Homo sapiens_hsa030180.65133585
69Tuberculosis_Homo sapiens_hsa051520.64936743
70Pertussis_Homo sapiens_hsa051330.60817732
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60582033
72Nucleotide excision repair_Homo sapiens_hsa034200.58850374
73Systemic lupus erythematosus_Homo sapiens_hsa053220.56256624
74Homologous recombination_Homo sapiens_hsa034400.52225812
75Non-small cell lung cancer_Homo sapiens_hsa052230.51216463
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.50201142
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49545825
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49466089
79Notch signaling pathway_Homo sapiens_hsa043300.49423087
80Other glycan degradation_Homo sapiens_hsa005110.47473478
81Caffeine metabolism_Homo sapiens_hsa002320.47318320
82Salmonella infection_Homo sapiens_hsa051320.46989580
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46889047
84Small cell lung cancer_Homo sapiens_hsa052220.43870996
85Pyrimidine metabolism_Homo sapiens_hsa002400.43100890
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40981933
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.39945653
88Dorso-ventral axis formation_Homo sapiens_hsa043200.39540573
89RNA polymerase_Homo sapiens_hsa030200.35737335
90FoxO signaling pathway_Homo sapiens_hsa040680.35625739
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35169130
92Renal cell carcinoma_Homo sapiens_hsa052110.34387836
93Rheumatoid arthritis_Homo sapiens_hsa053230.34256098
94RNA transport_Homo sapiens_hsa030130.34215133
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34044470
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.30283271
97Endocytosis_Homo sapiens_hsa041440.30072759
98mTOR signaling pathway_Homo sapiens_hsa041500.29854948
99Rap1 signaling pathway_Homo sapiens_hsa040150.29746101
100Proteasome_Homo sapiens_hsa030500.27861397
101Inositol phosphate metabolism_Homo sapiens_hsa005620.27190677
102Insulin resistance_Homo sapiens_hsa049310.26433391
103Fanconi anemia pathway_Homo sapiens_hsa034600.26251022
104HIF-1 signaling pathway_Homo sapiens_hsa040660.25838046
105Ether lipid metabolism_Homo sapiens_hsa005650.25449541
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24141043
107mRNA surveillance pathway_Homo sapiens_hsa030150.24133719
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23593632
109Pathways in cancer_Homo sapiens_hsa052000.23510794
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.23108919
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22465537
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.21814994
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21398413
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20907255
115Pentose phosphate pathway_Homo sapiens_hsa000300.20786511
116MAPK signaling pathway_Homo sapiens_hsa040100.20477591
117Cell cycle_Homo sapiens_hsa041100.19559997
118African trypanosomiasis_Homo sapiens_hsa051430.19021183
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17712728
120Prostate cancer_Homo sapiens_hsa052150.17149690
121Choline metabolism in cancer_Homo sapiens_hsa052310.14168242
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13779836
123Endometrial cancer_Homo sapiens_hsa052130.10681880
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.09008195

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