IL2RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.79365281
2positive regulation of gamma-delta T cell activation (GO:0046645)6.27623342
3tolerance induction (GO:0002507)6.21530250
4negative T cell selection (GO:0043383)5.84352317
5regulation of vitamin D biosynthetic process (GO:0060556)5.77274679
6regulation of interleukin-2 biosynthetic process (GO:0045076)5.73583960
7regulation of gamma-delta T cell differentiation (GO:0045586)5.58879307
8tyrosine phosphorylation of STAT protein (GO:0007260)5.54408765
9negative thymic T cell selection (GO:0045060)5.53560265
10positive regulation of natural killer cell differentiation (GO:0032825)5.46606930
11regulation of isotype switching to IgG isotypes (GO:0048302)5.40592293
12regulation of regulatory T cell differentiation (GO:0045589)5.24025857
13regulation of gamma-delta T cell activation (GO:0046643)5.02901549
14cytidine deamination (GO:0009972)4.86725190
15cytidine metabolic process (GO:0046087)4.86725190
16cytidine catabolic process (GO:0006216)4.86725190
17regulation of interleukin-12 biosynthetic process (GO:0045075)4.85321809
18regulation of T-helper 1 cell differentiation (GO:0045625)4.78417045
19* response to interleukin-15 (GO:0070672)4.74410703
20regulation of immunoglobulin secretion (GO:0051023)4.70538692
21positive regulation of interleukin-2 production (GO:0032743)4.65113231
22regulation of vitamin metabolic process (GO:0030656)4.57680207
23positive regulation of interleukin-17 production (GO:0032740)4.55478262
24pyrimidine ribonucleoside catabolic process (GO:0046133)4.49071659
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.48975174
26interferon-gamma production (GO:0032609)4.48508894
27positive regulation of T cell cytokine production (GO:0002726)4.46744561
28positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.44663732
29positive regulation of isotype switching (GO:0045830)4.43780685
30CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.41895475
31T cell selection (GO:0045058)4.41734268
32positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.40931653
33thymic T cell selection (GO:0045061)4.38458480
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32879672
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32879672
36positive T cell selection (GO:0043368)4.30842595
37positive regulation of defense response to virus by host (GO:0002230)4.30465302
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.27496288
39positive regulation of immunoglobulin mediated immune response (GO:0002891)4.21299517
40positive regulation of B cell mediated immunity (GO:0002714)4.21299517
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18623500
42positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.18156210
43positive regulation of natural killer cell mediated immunity (GO:0002717)4.18156210
44positive regulation of humoral immune response (GO:0002922)4.15650706
45positive thymic T cell selection (GO:0045059)4.15634951
46regulation of memory T cell differentiation (GO:0043380)4.15612326
47defense response to protozoan (GO:0042832)4.15315214
48regulation of podosome assembly (GO:0071801)4.14142643
49regulation of alpha-beta T cell proliferation (GO:0046640)4.10195508
50T cell costimulation (GO:0031295)4.05455096
51DNA deamination (GO:0045006)4.04202085
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.01256541
53lymphocyte costimulation (GO:0031294)3.99390500
54negative regulation of viral genome replication (GO:0045071)3.96778288
55regulation of chronic inflammatory response (GO:0002676)3.95985573
56negative regulation of interleukin-12 production (GO:0032695)3.94088019
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.92430658
58regulation of natural killer cell mediated immunity (GO:0002715)3.92430658
59regulation of interleukin-2 production (GO:0032663)3.91019845
60positive regulation of tolerance induction (GO:0002645)3.90316615
61activated T cell proliferation (GO:0050798)3.89957732
62regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.85055362
63regulation of lymphocyte chemotaxis (GO:1901623)3.85002017
64positive regulation of alpha-beta T cell proliferation (GO:0046641)3.84409073
65myeloid dendritic cell differentiation (GO:0043011)3.80918572
66response to protozoan (GO:0001562)3.80594026
67cellular response to type I interferon (GO:0071357)3.80434721
68type I interferon signaling pathway (GO:0060337)3.80434721
69positive regulation of chemokine biosynthetic process (GO:0045080)3.79263583
70antigen processing and presentation of endogenous antigen (GO:0019883)3.78670346
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78068275
72eosinophil chemotaxis (GO:0048245)3.76532754
73positive regulation of lymphocyte mediated immunity (GO:0002708)3.75824465
74response to type I interferon (GO:0034340)3.75118247
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.74803656
76positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.73633742
77positive regulation of DNA recombination (GO:0045911)3.73054218
78T cell receptor signaling pathway (GO:0050852)3.71268618
79NIK/NF-kappaB signaling (GO:0038061)3.70010209
80negative regulation of cell killing (GO:0031342)3.68343279
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.68343279
82positive regulation of immunoglobulin production (GO:0002639)3.67402218
83regulation of isotype switching (GO:0045191)3.66288313
84regulation of natural killer cell differentiation (GO:0032823)3.62313500
85regulation of T-helper cell differentiation (GO:0045622)3.57930626
86regulation of immunoglobulin production (GO:0002637)3.57306584
87regulation of immunoglobulin mediated immune response (GO:0002889)3.56509544
88alpha-beta T cell differentiation involved in immune response (GO:0002293)3.55454255
89alpha-beta T cell activation involved in immune response (GO:0002287)3.55454255
90T cell differentiation involved in immune response (GO:0002292)3.55454255
91regulation of interleukin-12 production (GO:0032655)3.55070838
92regulation of T cell tolerance induction (GO:0002664)3.55034417
93myeloid dendritic cell activation (GO:0001773)3.54502580
94positive regulation of interleukin-12 production (GO:0032735)3.52981912
95T cell homeostasis (GO:0043029)3.52438020
96regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.52380014
97regulation of tolerance induction (GO:0002643)3.49664242
98positive regulation of macrophage differentiation (GO:0045651)3.49614684
99* positive regulation of activated T cell proliferation (GO:0042104)3.49602502
100mucosal-associated lymphoid tissue development (GO:0048537)3.47967767
101Peyers patch development (GO:0048541)3.47967767
102regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.47785308
103positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.47785308
104T cell lineage commitment (GO:0002360)3.47097507
105regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.46904140
106regulation of B cell mediated immunity (GO:0002712)3.46419440
107negative regulation by host of viral transcription (GO:0043922)3.43392164
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.43297628
109negative regulation of T cell mediated immunity (GO:0002710)3.41014149
110positive regulation of cell killing (GO:0031343)3.40683107
111negative regulation of thymocyte apoptotic process (GO:0070244)3.39437409
112regulation of leukocyte mediated cytotoxicity (GO:0001910)3.38806016
113eosinophil migration (GO:0072677)3.36062895
114alpha-beta T cell differentiation (GO:0046632)3.31700168
115alpha-beta T cell activation (GO:0046631)3.29793323
116positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.27827194
117interferon-gamma-mediated signaling pathway (GO:0060333)3.25593946
118leukocyte aggregation (GO:0070486)3.25028462
119regulation of lymphocyte mediated immunity (GO:0002706)3.24465691
120regulation of T-helper 1 type immune response (GO:0002825)3.24300150
121lymphocyte chemotaxis (GO:0048247)3.23165223
122regulation of T cell cytokine production (GO:0002724)3.23164307
123* cellular response to interleukin-15 (GO:0071350)3.22868157
124positive regulation of lymphocyte migration (GO:2000403)3.21582547
125negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21376780
126regulation of interleukin-1 beta secretion (GO:0050706)3.20795767
127regulation of cytokine production involved in inflammatory response (GO:1900015)3.20021046
128regulation of chemokine biosynthetic process (GO:0045073)3.19947564
129positive regulation of cell fate commitment (GO:0010455)3.19808772
130positive regulation of leukocyte mediated immunity (GO:0002705)3.19444127
131positive regulation of interleukin-1 beta secretion (GO:0050718)3.19109264
132regulation of mononuclear cell migration (GO:0071675)3.18341755
133positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13952371
134regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.13288102
135positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.13059683
136positive regulation of T cell mediated immunity (GO:0002711)3.11189748
137T cell migration (GO:0072678)3.10768463
138antigen receptor-mediated signaling pathway (GO:0050851)3.10310647
139positive regulation of calcium-mediated signaling (GO:0050850)3.10193228
140regulation of response to interferon-gamma (GO:0060330)3.09792042
141regulation of cell killing (GO:0031341)3.09191665
142regulation of activation of Janus kinase activity (GO:0010533)3.08904717
143positive regulation of interleukin-10 production (GO:0032733)3.08851879
144T-helper cell differentiation (GO:0042093)3.08168958
145CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.08168958
146natural killer cell activation (GO:0030101)3.07895845
147positive regulation of astrocyte differentiation (GO:0048711)3.06902036
148positive regulation of T-helper 1 type immune response (GO:0002827)3.06012134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.56096211
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.48841292
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.58879999
4* BP1_19119308_ChIP-ChIP_Hs578T_Human5.04648865
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.96620072
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.85666186
7MYC_22102868_ChIP-Seq_BL_Human3.74405674
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.64585960
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35873156
10RUNX_20019798_ChIP-Seq_JUKART_Human3.07053398
11* MYB_26560356_Chip-Seq_TH2_Human3.04985024
12MAF_26560356_Chip-Seq_TH1_Human2.81729116
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79323154
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.70921534
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63978643
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61338955
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54610610
18* MYB_26560356_Chip-Seq_TH1_Human2.50405118
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.36771764
20VDR_21846776_ChIP-Seq_THP-1_Human2.35901589
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35633860
22UTX_26944678_Chip-Seq_JUKART_Human2.26526991
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08203148
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.07330596
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05833538
26TCF7_22412390_ChIP-Seq_EML_Mouse2.01538838
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94931053
28* MAF_26560356_Chip-Seq_TH2_Human1.93977631
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90173888
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83231126
31VDR_24763502_ChIP-Seq_THP-1_Human1.79266886
32GATA1_22025678_ChIP-Seq_K562_Human1.77888275
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76883186
34* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75280051
35* GATA3_27048872_Chip-Seq_THYMUS_Human1.72843493
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72682034
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67498332
38* KDM2B_26808549_Chip-Seq_DND41_Human1.63518117
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63011368
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61810396
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.60770395
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.58379877
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52172029
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49088587
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43669157
46SPI1_23547873_ChIP-Seq_NB4_Human1.42767553
47CIITA_25753668_ChIP-Seq_RAJI_Human1.42131402
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41641751
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41411279
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.39653942
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39394659
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37820956
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.37134214
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36958183
55SCL_19346495_ChIP-Seq_HPC-7_Human1.34229860
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34064864
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.31543506
58* IRF8_27001747_Chip-Seq_BMDM_Mouse1.30116224
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28054074
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26785822
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24554832
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23165612
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21143476
64VDR_23849224_ChIP-Seq_CD4+_Human1.19685050
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18465637
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15199041
67* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13213871
68* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12294928
69PU_27001747_Chip-Seq_BMDM_Mouse1.11282420
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10525248
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09968118
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08999799
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08287368
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05378872
75* FOXP3_21729870_ChIP-Seq_TREG_Human1.05014060
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03931572
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03613913
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03046419
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02865527
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02745164
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02672376
82SPI1_23127762_ChIP-Seq_K562_Human1.02492620
83XRN2_22483619_ChIP-Seq_HELA_Human1.02393586
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00780196
85GATA3_26560356_Chip-Seq_TH2_Human1.00525089
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99449343
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97134585
88ELK1_19687146_ChIP-ChIP_HELA_Human0.95735880
89KDM5A_27292631_Chip-Seq_BREAST_Human0.95500275
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94330241
91EGR1_19032775_ChIP-ChIP_M12_Human0.93974066
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.91789760
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91426966
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.90835701
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90604535
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90403382
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87749859
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87287773
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87011764
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86924400
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86765585
102AR_21909140_ChIP-Seq_LNCAP_Human0.86630340
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.86116396
104HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85053371
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83550406
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81802172
107NCOR1_26117541_ChIP-Seq_K562_Human0.81640247
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81490645
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.81411524
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80936142
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80006019
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79588003
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.78068411
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77747342
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76835415
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76303255
117TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75823465
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.75506846
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.74477579
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74160440
121GABP_17652178_ChIP-ChIP_JURKAT_Human0.72879038
122EST1_17652178_ChIP-ChIP_JURKAT_Human0.72874356
123RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72419817
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72131500
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71612895
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71532158
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.70752809
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69322709
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68837531
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67521350
131ELF5_23300383_ChIP-Seq_T47D_Human0.66813011
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.66216932
133GATA3_26560356_Chip-Seq_TH1_Human0.65954011
134* STAT1_20625510_ChIP-Seq_HELA_Human0.64911533
135SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.64795363
136* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64572014
137TTF2_22483619_ChIP-Seq_HELA_Human0.64438873
138VDR_24787735_ChIP-Seq_THP-1_Human0.64225077
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63843876
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.63728443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.53766334
2MP0003300_gastrointestinal_ulcer4.05757139
3MP0005671_abnormal_response_to3.98908608
4MP0000685_abnormal_immune_system3.75045547
5MP0003436_decreased_susceptibility_to3.30664531
6MP0001790_abnormal_immune_system3.24677777
7MP0005387_immune_system_phenotype3.24677777
8MP0001835_abnormal_antigen_presentation3.07527816
9MP0009333_abnormal_splenocyte_physiolog3.02992600
10* MP0001800_abnormal_humoral_immune2.92134326
11MP0002396_abnormal_hematopoietic_system2.86322346
12MP0005000_abnormal_immune_tolerance2.79502214
13MP0009785_altered_susceptibility_to2.68966645
14MP0002405_respiratory_system_inflammati2.67655470
15MP0000703_abnormal_thymus_morphology2.53779308
16* MP0002398_abnormal_bone_marrow2.52060357
17MP0002166_altered_tumor_susceptibility2.51431650
18* MP0002723_abnormal_immune_serum2.50309329
19MP0001873_stomach_inflammation2.47972381
20MP0003303_peritoneal_inflammation2.41663008
21* MP0003866_abnormal_defecation2.39436973
22* MP0002420_abnormal_adaptive_immunity2.32942745
23MP0001853_heart_inflammation2.32427124
24* MP0002452_abnormal_antigen_presenting2.29587421
25* MP0010155_abnormal_intestine_physiology2.28836379
26* MP0001819_abnormal_immune_cell2.28607395
27MP0002006_tumorigenesis2.17449710
28MP0005025_abnormal_response_to2.15304135
29MP0008057_abnormal_DNA_replication2.15285313
30* MP0000716_abnormal_immune_system2.11943429
31* MP0002722_abnormal_immune_system2.07655682
32MP0002933_joint_inflammation2.05512479
33* MP0000689_abnormal_spleen_morphology1.99842599
34MP0002148_abnormal_hypersensitivity_rea1.98854638
35MP0004808_abnormal_hematopoietic_stem1.94047438
36MP0004510_myositis1.89388000
37MP0010352_gastrointestinal_tract_polyps1.80053446
38* MP0002429_abnormal_blood_cell1.76084414
39MP0003724_increased_susceptibility_to1.64200539
40MP0000490_abnormal_crypts_of1.59489744
41MP0005076_abnormal_cell_differentiation1.58266371
42MP0000465_gastrointestinal_hemorrhage1.56717954
43* MP0001845_abnormal_inflammatory_respons1.55421788
44MP0004947_skin_inflammation1.55042934
45MP0006082_CNS_inflammation1.54181322
46MP0005310_abnormal_salivary_gland1.49636835
47MP0002419_abnormal_innate_immunity1.48915664
48MP0010094_abnormal_chromosome_stability1.47603272
49MP0005451_abnormal_body_composition1.46171330
50MP0003045_fibrosis1.32214543
51MP0004381_abnormal_hair_follicle1.31717199
52MP0003448_altered_tumor_morphology1.23957311
53MP0003693_abnormal_embryo_hatching1.22963810
54MP0001545_abnormal_hematopoietic_system1.20569469
55MP0005397_hematopoietic_system_phenotyp1.20569469
56MP0003077_abnormal_cell_cycle1.20406697
57MP0001533_abnormal_skeleton_physiology1.18471977
58MP0001881_abnormal_mammary_gland1.17974426
59MP0002163_abnormal_gland_morphology1.12432059
60MP0005464_abnormal_platelet_physiology1.08974257
61MP0005166_decreased_susceptibility_to1.08749252
62MP0002277_abnormal_respiratory_mucosa1.08590533
63MP0002019_abnormal_tumor_incidence1.07274456
64MP0003075_altered_response_to1.06863842
65MP0000569_abnormal_digit_pigmentation1.05813724
66MP0003111_abnormal_nucleus_morphology1.03983593
67MP0000858_altered_metastatic_potential1.03305634
68MP0002877_abnormal_melanocyte_morpholog0.99169428
69MP0008469_abnormal_protein_level0.96527073
70MP0002254_reproductive_system_inflammat0.95939355
71MP0008961_abnormal_basal_metabolism0.91635952
72MP0000350_abnormal_cell_proliferation0.89660745
73MP0004957_abnormal_blastocyst_morpholog0.87631983
74MP0008007_abnormal_cellular_replicative0.87611351
75MP0010307_abnormal_tumor_latency0.87399765
76MP0009278_abnormal_bone_marrow0.86935211
77MP0001851_eye_inflammation0.86492493
78MP0002693_abnormal_pancreas_physiology0.84806664
79MP0000604_amyloidosis0.82372468
80MP0002138_abnormal_hepatobiliary_system0.80007895
81MP0000343_altered_response_to0.77852658
82MP0002332_abnormal_exercise_endurance0.77711707
83MP0000627_abnormal_mammary_gland0.77520961
84MP0005058_abnormal_lysosome_morphology0.77100712
85MP0000372_irregular_coat_pigmentation0.76294177
86MP0003806_abnormal_nucleotide_metabolis0.75950621
87MP0000477_abnormal_intestine_morphology0.74495540
88MP0009764_decreased_sensitivity_to0.73194888
89MP0003172_abnormal_lysosome_physiology0.72713722
90MP0002998_abnormal_bone_remodeling0.71155500
91MP0003646_muscle_fatigue0.70551712
92MP0001919_abnormal_reproductive_system0.66952866
93MP0001348_abnormal_lacrimal_gland0.66709342
94MP0005381_digestive/alimentary_phenotyp0.65568401
95MP0001663_abnormal_digestive_system0.65411155
96MP0000313_abnormal_cell_death0.65387465
97MP0005023_abnormal_wound_healing0.64373742
98MP0003195_calcinosis0.63407559
99MP0005167_abnormal_blood-brain_barrier0.63317356
100MP0002009_preneoplasia0.63267405
101MP0001958_emphysema0.61893882
102MP0002139_abnormal_hepatobiliary_system0.60788858
103MP0008877_abnormal_DNA_methylation0.60337689
104MP0001730_embryonic_growth_arrest0.60335420
105MP0005379_endocrine/exocrine_gland_phen0.59682898
106MP0002088_abnormal_embryonic_growth/wei0.56972834
107MP0001727_abnormal_embryo_implantation0.56630661
108MP0008004_abnormal_stomach_pH0.56282974
109MP0009765_abnormal_xenobiotic_induced0.55971955
110MP0000609_abnormal_liver_physiology0.54660654
111MP0005075_abnormal_melanosome_morpholog0.54592841
112MP0009763_increased_sensitivity_to0.53789028
113MP0000371_diluted_coat_color0.53738608
114MP0009840_abnormal_foam_cell0.53294171
115MP0003984_embryonic_growth_retardation0.53287207
116MP0001501_abnormal_sleep_pattern0.52811353
117MP0001243_abnormal_dermal_layer0.52439452
118MP0008873_increased_physiological_sensi0.52308335
119MP0005165_increased_susceptibility_to0.51212222
120MP0001216_abnormal_epidermal_layer0.50461087
121MP0003453_abnormal_keratinocyte_physiol0.50452807
122MP0002086_abnormal_extraembryonic_tissu0.47808896
123MP0005390_skeleton_phenotype0.47181657
124MP0008058_abnormal_DNA_repair0.46739218
125MP0001849_ear_inflammation0.46222057
126MP0001672_abnormal_embryogenesis/_devel0.46029531
127MP0005380_embryogenesis_phenotype0.46029531
128MP0002136_abnormal_kidney_physiology0.46026985
129MP0005584_abnormal_enzyme/coenzyme_acti0.44353583
130MP0003091_abnormal_cell_migration0.43849295

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.84613246
2Optic neuritis (HP:0100653)4.84613246
3Stomatitis (HP:0010280)4.65499013
4Myositis (HP:0100614)4.63863401
5* T lymphocytopenia (HP:0005403)4.62153310
6IgM deficiency (HP:0002850)4.57552385
7Panhypogammaglobulinemia (HP:0003139)4.56543813
8* Abnormality of T cell number (HP:0011839)4.46623545
9Recurrent cutaneous fungal infections (HP:0011370)4.46464155
10Chronic mucocutaneous candidiasis (HP:0002728)4.46464155
11B lymphocytopenia (HP:0010976)4.44399949
12Abnormality of B cell number (HP:0010975)4.44399949
13Elevated erythrocyte sedimentation rate (HP:0003565)4.38392670
14Severe combined immunodeficiency (HP:0004430)4.37678816
15* Abnormality of T cells (HP:0002843)4.36548502
16* Recurrent fungal infections (HP:0002841)4.29928056
17Recurrent bronchitis (HP:0002837)4.16394535
18Orchitis (HP:0100796)4.10347842
19Abnormal delayed hypersensitivity skin test (HP:0002963)4.08939424
20Abnormality of T cell physiology (HP:0011840)4.04708178
21Increased density of long bones (HP:0006392)3.89396819
22Combined immunodeficiency (HP:0005387)3.88658489
23Autoimmune thrombocytopenia (HP:0001973)3.82485588
24IgG deficiency (HP:0004315)3.78947099
25Eczematoid dermatitis (HP:0000976)3.76853072
26Pulmonary infiltrates (HP:0002113)3.70152976
27Abnormality of the fingertips (HP:0001211)3.66056127
28* Recurrent viral infections (HP:0004429)3.61949122
29Hemoptysis (HP:0002105)3.60928302
30Persistence of primary teeth (HP:0006335)3.56848493
31* Chronic diarrhea (HP:0002028)3.48027745
32Arterial thrombosis (HP:0004420)3.36651668
33Inflammation of the large intestine (HP:0002037)3.34888102
34Nasal polyposis (HP:0100582)3.30505376
35Gastrointestinal inflammation (HP:0004386)3.29996866
36Vasculitis (HP:0002633)3.28170602
37Chronic otitis media (HP:0000389)3.25437647
38Keratoconjunctivitis sicca (HP:0001097)3.23039543
39Gastrointestinal infarctions (HP:0005244)3.20139549
40Thrombocytosis (HP:0001894)3.17982027
41Abnormality of macrophages (HP:0004311)3.17249918
42* IgA deficiency (HP:0002720)3.05881057
43Eosinophilia (HP:0001880)3.03295025
44Keratoconjunctivitis (HP:0001096)2.96636333
45Abnormality of liposaccharide metabolism (HP:0010968)2.95896122
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.95896122
47Abnormality of glycolipid metabolism (HP:0010969)2.95896122
48Increased IgM level (HP:0003496)2.89706614
49Mediastinal lymphadenopathy (HP:0100721)2.89638327
50Lymphoma (HP:0002665)2.88159587
51Abnormality of eosinophils (HP:0001879)2.88086312
52Meningitis (HP:0001287)2.86745177
53Cheilitis (HP:0100825)2.85710448
54Increased IgE level (HP:0003212)2.83714868
55Autoimmune hemolytic anemia (HP:0001890)2.81083248
56Leukocytosis (HP:0001974)2.74998753
57Acute myeloid leukemia (HP:0004808)2.73922628
58Polyneuropathy (HP:0001271)2.72266046
59Recurrent bacterial skin infections (HP:0005406)2.68856330
60Lymphopenia (HP:0001888)2.68165813
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.64070225
62Thyroiditis (HP:0100646)2.62992734
63Granulocytopenia (HP:0001913)2.61361570
64Abnormality of the nasal mucosa (HP:0000433)2.60995445
65Chest pain (HP:0100749)2.58843467
66Gangrene (HP:0100758)2.58209093
67Encephalitis (HP:0002383)2.52015167
68Pulmonary embolism (HP:0002204)2.50665177
69Aplastic anemia (HP:0001915)2.50322429
70Amaurosis fugax (HP:0100576)2.47308507
71Abnormality of the pericardium (HP:0001697)2.38663749
72Hypoproteinemia (HP:0003075)2.37129993
73Recurrent abscess formation (HP:0002722)2.33949715
74Cutis marmorata (HP:0000965)2.33796886
75Fatigue (HP:0012378)2.28780791
76Vacuolated lymphocytes (HP:0001922)2.27340712
77Gastrointestinal stroma tumor (HP:0100723)2.27157319
78Hypergammaglobulinemia (HP:0010702)2.26584632
79Pulmonary fibrosis (HP:0002206)2.26174389
80Bronchitis (HP:0012387)2.24559205
81Recurrent skin infections (HP:0001581)2.21942384
82Obstructive lung disease (HP:0006536)2.12480965
83Chronic obstructive pulmonary disease (HP:0006510)2.12480965
84Recurrent sinusitis (HP:0011108)2.12360321
85Basal cell carcinoma (HP:0002671)2.11540325
86Parakeratosis (HP:0001036)2.11331662
87Abnormality of the endocardium (HP:0004306)2.07445281
88Pustule (HP:0200039)2.04761917
89Abnormality of the prostate (HP:0008775)2.04140653
90* Joint swelling (HP:0001386)2.03939537
91Skin rash (HP:0000988)2.03510681
92Ureteral stenosis (HP:0000071)2.03190332
93Abnormality of the pleura (HP:0002103)2.01805857
94Acne (HP:0001061)1.99412551
95Gingival bleeding (HP:0000225)1.98903510
96Somatic mutation (HP:0001428)1.96810174
97Increased serum ferritin (HP:0003281)1.96545637
98Acute hepatic failure (HP:0006554)1.96297312
99Agammaglobulinemia (HP:0004432)1.96139512
100Interstitial pulmonary disease (HP:0006530)1.95562265
101Periodontitis (HP:0000704)1.94074500
102Abnormality of the peritoneum (HP:0002585)1.93824273
103Spontaneous hematomas (HP:0007420)1.93358431
104Thrombophlebitis (HP:0004418)1.91565302
105Leukopenia (HP:0001882)1.91493367
106Ureteral obstruction (HP:0006000)1.90429321
107Dyschromatopsia (HP:0007641)1.88798557
108Adactyly (HP:0009776)1.88773058
109Anorexia (HP:0002039)1.85587142
110Abnormal platelet volume (HP:0011876)1.84522167
111Gingivitis (HP:0000230)1.83823155
112Papilloma (HP:0012740)1.83649576
113Verrucae (HP:0200043)1.83649576
114Esophageal varix (HP:0002040)1.82825379
115Anhidrosis (HP:0000970)1.81851999
116Dysmetric saccades (HP:0000641)1.81316136
117Glomerulopathy (HP:0100820)1.81280736
118Hematochezia (HP:0002573)1.79670431
119Hypoplasia of the thymus (HP:0000778)1.78246030
120Keratitis (HP:0000491)1.77814873
121Episodic fever (HP:0001954)1.77752534
122Emphysema (HP:0002097)1.77497987
123Volvulus (HP:0002580)1.77114143
124* Arthralgia (HP:0002829)1.75809344
125Skull defect (HP:0001362)1.75260914
126Porencephaly (HP:0002132)1.75002324
127Systemic lupus erythematosus (HP:0002725)1.71406995
128Retinopathy (HP:0000488)1.71103690
129Pancreatitis (HP:0001733)1.69445494
130Alveolar cell carcinoma (HP:0006519)1.69297147
131Paresthesia (HP:0003401)1.67895581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.54961758
2MAP4K15.23873276
3JAK33.85546048
4EEF2K3.77272199
5ZAP702.80365644
6ITK2.71454160
7FGFR42.47666228
8GRK72.46591601
9MAP3K142.39593111
10CDK122.15272299
11STK102.03923252
12EPHB11.96380389
13MATK1.95517552
14RIPK41.90109334
15EPHA31.89528555
16FGFR31.88724385
17TSSK61.85771126
18TYK21.84825309
19ADRBK21.81141145
20NLK1.77256383
21TEC1.73063909
22TAOK21.63163025
23CDC71.57956585
24JAK11.53687899
25LCK1.53393788
26MAP2K61.52105783
27IRAK41.47947523
28ALK1.43131391
29TRIB31.41541179
30SYK1.41218846
31HCK1.39834332
32KDR1.39663109
33PIM21.37136023
34BTK1.36082172
35BMPR21.32147881
36EIF2AK31.31645419
37MAP3K71.27053578
38IKBKB1.22745993
39MAP3K101.20066310
40PKN21.18598772
41PIM11.18444849
42CHUK1.16255447
43GRK61.15060052
44IKBKE1.13766281
45CDK41.10088012
46JAK21.07840732
47CLK11.05687606
48PRPF4B1.05008705
49PRKCQ1.02465045
50LRRK21.01275395
51SIK21.00733830
52CSK0.99860927
53TBK10.99085015
54RIPK10.98761240
55NME10.95527662
56CAMKK20.94596573
57MST40.94354377
58MOS0.91387292
59MAPK110.89708912
60PIK3CA0.87714238
61CDK60.87005124
62MAPKAPK30.84960938
63FES0.84873260
64BRD40.84079413
65TLK10.83035532
66PASK0.82251749
67RPS6KA40.78784049
68TESK20.78335871
69NEK20.76405370
70PTK60.73664108
71NME20.72791118
72PRKCH0.72326285
73BLK0.72115750
74MAP3K130.71929787
75RPS6KB20.70469660
76TGFBR20.69241223
77HIPK20.64160223
78TAOK30.63600083
79MAP3K80.62616318
80CHEK10.60990533
81LYN0.60318389
82MAP3K30.60254213
83EIF2AK20.59408863
84TAOK10.58480254
85IRAK10.57868939
86FGFR10.53950193
87PDGFRB0.53371587
88SIK30.52394439
89CDK90.51087555
90NUAK10.51041899
91DAPK10.50915490
92MAP3K110.48308385
93MAPKAPK20.47049183
94WNK40.46036151
95ATR0.45879103
96DAPK20.45502206
97KIT0.43318493
98PDK10.43153398
99BCR0.42959932
100PLK30.42953460
101RAF10.42754070
102BCKDK0.42280711
103FGR0.42004778
104STK240.41598056
105STK40.41162602
106TNK20.40843472
107RPS6KB10.40785410
108MARK30.39714404
109EGFR0.38765494
110RPS6KA50.37314139
111MTOR0.37281392
112ROCK20.36988752
113MELK0.36611421
114PAK20.35550330
115MAP3K120.35208912
116ATM0.35130999
117TYRO30.34672205
118FYN0.34334608
119MAP2K30.33060990
120NTRK20.32768741
121TGFBR10.32548361
122SGK30.30841516
123SRPK10.30807808
124SIK10.30654437
125ACVR1B0.29989443
126CSF1R0.29489596
127DDR20.29365505
128IGF1R0.28908720
129CDK20.28575088
130MAP3K50.28555540
131IRAK30.28046394
132CSNK1D0.27997102
133MAP3K10.27555629
134MAP4K20.27074243
135MARK20.27070440
136VRK20.26900482
137CDC42BPA0.26403110
138INSR0.25368586
139RET0.24663297
140CAMKK10.23366882
141MAPK30.20332714
142MAPK40.14499284
143NTRK10.11233181

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.51461203
2Allograft rejection_Homo sapiens_hsa053303.97271277
3Primary immunodeficiency_Homo sapiens_hsa053403.69052898
4T cell receptor signaling pathway_Homo sapiens_hsa046603.38811624
5Asthma_Homo sapiens_hsa053103.16360828
6Autoimmune thyroid disease_Homo sapiens_hsa053203.12871925
7Type I diabetes mellitus_Homo sapiens_hsa049402.84851016
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.81957778
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.71455262
10Graft-versus-host disease_Homo sapiens_hsa053322.69691016
11* Measles_Homo sapiens_hsa051622.37432084
12* Jak-STAT signaling pathway_Homo sapiens_hsa046302.36662268
13Proteasome_Homo sapiens_hsa030502.03969704
14African trypanosomiasis_Homo sapiens_hsa051431.89306746
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80440236
16* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68432243
17Leishmaniasis_Homo sapiens_hsa051401.66004072
18Osteoclast differentiation_Homo sapiens_hsa043801.63341802
19Antigen processing and presentation_Homo sapiens_hsa046121.57992133
20Viral myocarditis_Homo sapiens_hsa054161.56062651
21Acute myeloid leukemia_Homo sapiens_hsa052211.55808589
22One carbon pool by folate_Homo sapiens_hsa006701.43473745
23B cell receptor signaling pathway_Homo sapiens_hsa046621.43263007
24Chronic myeloid leukemia_Homo sapiens_hsa052201.39284062
25* Hematopoietic cell lineage_Homo sapiens_hsa046401.39130638
26Herpes simplex infection_Homo sapiens_hsa051681.38425648
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36791152
28Toxoplasmosis_Homo sapiens_hsa051451.36083222
29TNF signaling pathway_Homo sapiens_hsa046681.32296440
30DNA replication_Homo sapiens_hsa030301.31813780
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26813577
32Hepatitis B_Homo sapiens_hsa051611.26341743
33Prolactin signaling pathway_Homo sapiens_hsa049171.24596945
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20884828
35* HTLV-I infection_Homo sapiens_hsa051661.19615002
36Viral carcinogenesis_Homo sapiens_hsa052031.18704178
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16273113
38Chemokine signaling pathway_Homo sapiens_hsa040621.15263412
39Non-homologous end-joining_Homo sapiens_hsa034501.10474556
40Epstein-Barr virus infection_Homo sapiens_hsa051691.06246967
41Spliceosome_Homo sapiens_hsa030401.00984836
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97955112
43Influenza A_Homo sapiens_hsa051640.96993491
44Legionellosis_Homo sapiens_hsa051340.95001848
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92398537
46RNA transport_Homo sapiens_hsa030130.92352304
47Apoptosis_Homo sapiens_hsa042100.91724514
48Pancreatic cancer_Homo sapiens_hsa052120.91066134
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89323670
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.88795181
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87804911
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80273523
53Small cell lung cancer_Homo sapiens_hsa052220.79833995
54mRNA surveillance pathway_Homo sapiens_hsa030150.79553029
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79447599
56Mismatch repair_Homo sapiens_hsa034300.78579604
57MicroRNAs in cancer_Homo sapiens_hsa052060.76759575
58Cell cycle_Homo sapiens_hsa041100.75522650
59Shigellosis_Homo sapiens_hsa051310.75111895
60Base excision repair_Homo sapiens_hsa034100.73672047
61Rheumatoid arthritis_Homo sapiens_hsa053230.70842209
62HIF-1 signaling pathway_Homo sapiens_hsa040660.69177917
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68382270
64Prion diseases_Homo sapiens_hsa050200.68077582
65RNA degradation_Homo sapiens_hsa030180.67202839
66p53 signaling pathway_Homo sapiens_hsa041150.64558778
67Ribosome_Homo sapiens_hsa030100.64408965
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.64332947
69Tuberculosis_Homo sapiens_hsa051520.64239707
70Colorectal cancer_Homo sapiens_hsa052100.63089384
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.61002883
72Lysosome_Homo sapiens_hsa041420.59765451
73Hepatitis C_Homo sapiens_hsa051600.57873425
74Renal cell carcinoma_Homo sapiens_hsa052110.57602201
75VEGF signaling pathway_Homo sapiens_hsa043700.56460338
76Malaria_Homo sapiens_hsa051440.56235246
77Non-small cell lung cancer_Homo sapiens_hsa052230.55012109
78Prostate cancer_Homo sapiens_hsa052150.53187446
79MAPK signaling pathway_Homo sapiens_hsa040100.49958677
80Pertussis_Homo sapiens_hsa051330.49908351
81Notch signaling pathway_Homo sapiens_hsa043300.48910254
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48884469
83Protein export_Homo sapiens_hsa030600.48587096
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47897466
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46433314
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43834075
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43165442
88mTOR signaling pathway_Homo sapiens_hsa041500.43040871
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.42930158
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41599197
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41571872
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.41326207
93Homologous recombination_Homo sapiens_hsa034400.41053296
94Salmonella infection_Homo sapiens_hsa051320.39019346
95Platelet activation_Homo sapiens_hsa046110.36167995
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35538111
97Thyroid cancer_Homo sapiens_hsa052160.35126116
98Systemic lupus erythematosus_Homo sapiens_hsa053220.32362117
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31305342
100Staphylococcus aureus infection_Homo sapiens_hsa051500.31248704
101Dorso-ventral axis formation_Homo sapiens_hsa043200.30830086
102Pathways in cancer_Homo sapiens_hsa052000.28730444
103FoxO signaling pathway_Homo sapiens_hsa040680.28505399
104Fanconi anemia pathway_Homo sapiens_hsa034600.27809266
105Nucleotide excision repair_Homo sapiens_hsa034200.26273465
106Lysine degradation_Homo sapiens_hsa003100.26141419
107Insulin resistance_Homo sapiens_hsa049310.25852177
108Sulfur metabolism_Homo sapiens_hsa009200.25179533
109ErbB signaling pathway_Homo sapiens_hsa040120.24943895
110Phagosome_Homo sapiens_hsa041450.24515169
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23161337
112Regulation of autophagy_Homo sapiens_hsa041400.22449223
113Amoebiasis_Homo sapiens_hsa051460.21868518
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21723448
115Type II diabetes mellitus_Homo sapiens_hsa049300.19392586
116Other glycan degradation_Homo sapiens_hsa005110.18868257
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17352779
118Endometrial cancer_Homo sapiens_hsa052130.17072141
119RNA polymerase_Homo sapiens_hsa030200.14975365
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.14828794
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13027874
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.08122056
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06407817
124Tryptophan metabolism_Homo sapiens_hsa003800.05084836
125Pyrimidine metabolism_Homo sapiens_hsa002400.04762263
126Collecting duct acid secretion_Homo sapiens_hsa049660.03467550
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.02111084
128Basal transcription factors_Homo sapiens_hsa03022-0.0613151
129Bladder cancer_Homo sapiens_hsa05219-0.0499782
130Linoleic acid metabolism_Homo sapiens_hsa00591-0.0471889
131Mineral absorption_Homo sapiens_hsa04978-0.0011442

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