IL2RB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)9.45518757
2positive regulation of gamma-delta T cell activation (GO:0046645)7.35314256
3negative T cell selection (GO:0043383)7.27075593
4negative thymic T cell selection (GO:0045060)7.24205666
5negative regulation of cell killing (GO:0031342)6.97005121
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.97005121
7positive thymic T cell selection (GO:0045059)6.62403502
8regulation of isotype switching to IgG isotypes (GO:0048302)6.44991160
9regulation of natural killer cell mediated immunity (GO:0002715)6.32335125
10regulation of natural killer cell mediated cytotoxicity (GO:0042269)6.32335125
11regulation of gamma-delta T cell differentiation (GO:0045586)6.28236948
12thymic T cell selection (GO:0045061)6.08459960
13* response to interleukin-15 (GO:0070672)5.93244874
14positive T cell selection (GO:0043368)5.85272691
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.83677141
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.83677141
17tolerance induction (GO:0002507)5.66199830
18regulation of gamma-delta T cell activation (GO:0046643)5.61229280
19T cell migration (GO:0072678)5.58901425
20activated T cell proliferation (GO:0050798)5.43480566
21T cell selection (GO:0045058)5.41693616
22cytolysis (GO:0019835)5.19586127
23* cellular response to interleukin-15 (GO:0071350)5.14754887
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.13888979
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.11274629
26positive regulation of natural killer cell mediated immunity (GO:0002717)5.11274629
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.10215883
28leukocyte aggregation (GO:0070486)5.10157038
29regulation of T cell tolerance induction (GO:0002664)5.09281197
30regulation of leukocyte mediated cytotoxicity (GO:0001910)5.02108919
31regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.93668446
32antigen processing and presentation of endogenous antigen (GO:0019883)4.84676465
33natural killer cell activation (GO:0030101)4.69219351
34T cell receptor signaling pathway (GO:0050852)4.66477625
35T cell costimulation (GO:0031295)4.65926129
36positive regulation of isotype switching (GO:0045830)4.63348799
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.60509371
38lymphocyte costimulation (GO:0031294)4.57335432
39regulation of cell killing (GO:0031341)4.57062751
40cellular defense response (GO:0006968)4.50924630
41regulation of B cell receptor signaling pathway (GO:0050855)4.34032320
42positive regulation of tolerance induction (GO:0002645)4.24136213
43positive regulation of cell killing (GO:0031343)4.17520169
44regulation of interleukin-2 biosynthetic process (GO:0045076)4.16993946
45positive regulation of immunoglobulin mediated immune response (GO:0002891)4.14314706
46positive regulation of B cell mediated immunity (GO:0002714)4.14314706
47negative regulation of T cell mediated immunity (GO:0002710)4.12371445
48regulation of alpha-beta T cell proliferation (GO:0046640)4.10080570
49regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.05848800
50regulation of response to interferon-gamma (GO:0060330)4.04191607
51positive regulation of alpha-beta T cell proliferation (GO:0046641)4.01172517
52regulation of isotype switching (GO:0045191)3.96356481
53antigen receptor-mediated signaling pathway (GO:0050851)3.94377548
54B cell receptor signaling pathway (GO:0050853)3.94025820
55positive regulation of DNA recombination (GO:0045911)3.93789950
56negative regulation of leukocyte mediated immunity (GO:0002704)3.88994943
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88067045
58positive regulation of humoral immune response (GO:0002922)3.86550133
59regulation of memory T cell differentiation (GO:0043380)3.86529773
60type I interferon signaling pathway (GO:0060337)3.84814521
61cellular response to type I interferon (GO:0071357)3.84814521
62response to type I interferon (GO:0034340)3.82767231
63antigen processing and presentation via MHC class Ib (GO:0002475)3.81648682
64alpha-beta T cell activation (GO:0046631)3.77151331
65positive regulation of interleukin-2 production (GO:0032743)3.75591358
66regulation of immunoglobulin mediated immune response (GO:0002889)3.74609302
67alpha-beta T cell differentiation (GO:0046632)3.74264316
68regulation of regulatory T cell differentiation (GO:0045589)3.71537873
69alpha-beta T cell differentiation involved in immune response (GO:0002293)3.67652110
70alpha-beta T cell activation involved in immune response (GO:0002287)3.67652110
71T cell differentiation involved in immune response (GO:0002292)3.67652110
72regulation of interleukin-12 biosynthetic process (GO:0045075)3.66766928
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.65991731
74regulation of tolerance induction (GO:0002643)3.65726993
75regulation of lymphocyte mediated immunity (GO:0002706)3.65459855
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.63729580
77positive regulation of T cell mediated cytotoxicity (GO:0001916)3.62700738
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62571352
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62571352
80positive regulation by organism of defense response of other organism involved in symbiotic interact3.62571352
81modulation by symbiont of host immune response (GO:0052553)3.62571352
82positive regulation by symbiont of host defense response (GO:0052509)3.62571352
83modulation by symbiont of host defense response (GO:0052031)3.62571352
84positive regulation of lymphocyte mediated immunity (GO:0002708)3.61368735
85regulation of B cell mediated immunity (GO:0002712)3.60888909
86detection of bacterium (GO:0016045)3.56467743
87response to muramyl dipeptide (GO:0032495)3.54572650
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.52350891
89T-helper cell differentiation (GO:0042093)3.52350891
90regulation of T cell mediated cytotoxicity (GO:0001914)3.51653448
91regulation of T cell receptor signaling pathway (GO:0050856)3.51562959
92immunoglobulin mediated immune response (GO:0016064)3.47712610
93leukocyte cell-cell adhesion (GO:0007159)3.47070318
94lymphocyte migration (GO:0072676)3.46816687
95negative regulation of innate immune response (GO:0045824)3.45386323
96T cell differentiation (GO:0030217)3.45156270
97positive regulation of interferon-gamma production (GO:0032729)3.43657612
98regulation of B cell differentiation (GO:0045577)3.41917821
99tyrosine phosphorylation of STAT protein (GO:0007260)3.41220245
100positive regulation of B cell differentiation (GO:0045579)3.40617667
101detection of other organism (GO:0098543)3.40479634
102positive regulation of immunoglobulin production (GO:0002639)3.40434148
103cellular extravasation (GO:0045123)3.40430599
104negative regulation of lymphocyte mediated immunity (GO:0002707)3.40274546
105CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.38243094
106positive regulation of T-helper 1 type immune response (GO:0002827)3.36806159
107T cell homeostasis (GO:0043029)3.36174463
108T cell activation involved in immune response (GO:0002286)3.32293181
109positive regulation of defense response to virus by host (GO:0002230)3.29138668
110interferon-gamma-mediated signaling pathway (GO:0060333)3.24431548
111T cell proliferation (GO:0042098)3.24063115
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23112534
113T cell activation (GO:0042110)3.16765002
114regulation of immunoglobulin production (GO:0002637)3.16737141
115NIK/NF-kappaB signaling (GO:0038061)3.16398507
116neutrophil activation involved in immune response (GO:0002283)3.15551279
117macrophage activation involved in immune response (GO:0002281)3.15156146
118natural killer cell differentiation (GO:0001779)3.14242590
119regulation of type I interferon-mediated signaling pathway (GO:0060338)3.13444946
120mast cell activation (GO:0045576)3.13376750
121regulation of T-helper 1 type immune response (GO:0002825)3.13209128
122positive regulation of granulocyte differentiation (GO:0030854)3.12017125
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11925067
124regulation of T cell mediated immunity (GO:0002709)3.10842456
125heterotypic cell-cell adhesion (GO:0034113)3.10704369
126B cell homeostasis (GO:0001782)3.10598601
127positive regulation of T cell mediated immunity (GO:0002711)3.10522861
128Peyers patch development (GO:0048541)3.10042124
129mucosal-associated lymphoid tissue development (GO:0048537)3.10042124
130negative regulation of T cell receptor signaling pathway (GO:0050860)3.08491204
131regulation of interleukin-2 production (GO:0032663)3.08071896
132leukocyte degranulation (GO:0043299)3.07604078
133positive regulation of leukocyte mediated immunity (GO:0002705)3.05704055
134negative regulation of interleukin-12 production (GO:0032695)3.05348600
135negative regulation of phagocytosis (GO:0050765)3.04166380
136regulation of alpha-beta T cell activation (GO:0046634)3.02787911
137B cell mediated immunity (GO:0019724)3.01063184
138myeloid dendritic cell differentiation (GO:0043011)2.99037276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.62582381
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.71440922
3* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.48645106
4STAT4_19710469_ChIP-ChIP_TH1__Mouse4.23349875
5RUNX_20019798_ChIP-Seq_JUKART_Human3.99290232
6MYC_22102868_ChIP-Seq_BL_Human3.57180439
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.56510592
8MYB_26560356_Chip-Seq_TH2_Human3.56099845
9E2F7_22180533_ChIP-Seq_HELA_Human3.48994018
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.24599091
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20131147
12MAF_26560356_Chip-Seq_TH1_Human3.13820728
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.06211537
14MYB_26560356_Chip-Seq_TH1_Human3.06150958
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00638010
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.99371743
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.92903406
18UTX_26944678_Chip-Seq_JUKART_Human2.78711789
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44713206
20VDR_21846776_ChIP-Seq_THP-1_Human2.40148195
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.36871771
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28161130
23TCF7_22412390_ChIP-Seq_EML_Mouse2.23100234
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.19379402
25MAF_26560356_Chip-Seq_TH2_Human2.17845621
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.17230190
27GATA3_27048872_Chip-Seq_THYMUS_Human2.15473085
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.10179479
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.06756045
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98148794
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96627390
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95627405
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93459896
34KDM2B_26808549_Chip-Seq_DND41_Human1.92997315
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86131312
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82918580
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.82188981
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.81702003
39VDR_24763502_ChIP-Seq_THP-1_Human1.80865771
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80277757
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70902860
42SPI1_23547873_ChIP-Seq_NB4_Human1.68586270
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66937592
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63508518
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63259518
46SCL_19346495_ChIP-Seq_HPC-7_Human1.62620949
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60255248
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54194209
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45134627
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42190940
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41386978
52GATA1_22025678_ChIP-Seq_K562_Human1.39511922
53SPI1_23127762_ChIP-Seq_K562_Human1.36522074
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.34072785
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28596975
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27910243
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.27169606
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24668559
59GATA3_26560356_Chip-Seq_TH2_Human1.24350778
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21983487
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19815782
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17449805
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.16280049
64BCL6_27268052_Chip-Seq_Bcells_Human1.15151720
65PU_27001747_Chip-Seq_BMDM_Mouse1.14815689
66CIITA_25753668_ChIP-Seq_RAJI_Human1.14127670
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12677980
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08448816
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07090987
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06203777
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03986886
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02982044
73NCOR1_26117541_ChIP-Seq_K562_Human0.98808185
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97709176
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97453092
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96173738
77IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94705671
78BCOR_27268052_Chip-Seq_Bcells_Human0.94659733
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90185688
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.89099245
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88443810
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86525275
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85766457
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85295115
85LXR_22292898_ChIP-Seq_THP-1_Human0.84260950
86SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.82815190
87VDR_24787735_ChIP-Seq_THP-1_Human0.81817591
88P300_27268052_Chip-Seq_Bcells_Human0.80993086
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80193194
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80192516
91GATA3_26560356_Chip-Seq_TH1_Human0.80145039
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.79237852
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77941841
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77832614
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77567062
96GATA1_19941826_ChIP-Seq_K562_Human0.77549170
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76957337
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75794864
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75527716
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75500069
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75230411
102GATA2_19941826_ChIP-Seq_K562_Human0.74826627
103VDR_23849224_ChIP-Seq_CD4+_Human0.74322562
104* SA1_27219007_Chip-Seq_ERYTHROID_Human0.74251237
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.72975638
106SPI1_20517297_ChIP-Seq_HL60_Human0.72659218
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69327935
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.69304161
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67643125
110* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67534734
111ERG_20887958_ChIP-Seq_HPC-7_Mouse0.67194559
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67178868
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65958571
114FOXP3_21729870_ChIP-Seq_TREG_Human0.64540695
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.63589851
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63443994
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.61838765
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61178449
119CLOCK_20551151_ChIP-Seq_293T_Human0.59217902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005671_abnormal_response_to5.34864097
2MP0003763_abnormal_thymus_physiology4.73788745
3MP0006082_CNS_inflammation4.62955930
4MP0000685_abnormal_immune_system3.33162947
5* MP0001800_abnormal_humoral_immune3.24950500
6MP0001835_abnormal_antigen_presentation3.21590152
7MP0009785_altered_susceptibility_to3.19025577
8MP0001790_abnormal_immune_system3.18081363
9MP0005387_immune_system_phenotype3.18081363
10* MP0002420_abnormal_adaptive_immunity2.86946234
11* MP0002723_abnormal_immune_serum2.84967773
12* MP0001819_abnormal_immune_cell2.82798153
13MP0009333_abnormal_splenocyte_physiolog2.82064346
14* MP0005000_abnormal_immune_tolerance2.79676759
15MP0005025_abnormal_response_to2.68819697
16MP0003300_gastrointestinal_ulcer2.64178841
17* MP0002398_abnormal_bone_marrow2.62305261
18MP0001873_stomach_inflammation2.58569739
19MP0002405_respiratory_system_inflammati2.58433862
20MP0003866_abnormal_defecation2.57970317
21* MP0002452_abnormal_antigen_presenting2.50873550
22MP0010155_abnormal_intestine_physiology2.46287786
23MP0002166_altered_tumor_susceptibility2.43852598
24* MP0000703_abnormal_thymus_morphology2.38052735
25MP0003448_altered_tumor_morphology2.36624639
26* MP0000716_abnormal_immune_system2.34209557
27MP0003436_decreased_susceptibility_to2.29801759
28MP0002006_tumorigenesis2.25045254
29MP0003724_increased_susceptibility_to2.24098558
30* MP0002722_abnormal_immune_system2.19281325
31MP0004947_skin_inflammation2.05836538
32* MP0000689_abnormal_spleen_morphology2.04385195
33MP0002933_joint_inflammation2.03809560
34MP0002396_abnormal_hematopoietic_system1.91335290
35MP0000858_altered_metastatic_potential1.88728818
36* MP0002429_abnormal_blood_cell1.88576807
37MP0002148_abnormal_hypersensitivity_rea1.78239408
38MP0004510_myositis1.76410133
39MP0002419_abnormal_innate_immunity1.75624265
40* MP0001845_abnormal_inflammatory_respons1.72940855
41MP0010307_abnormal_tumor_latency1.64431950
42MP0005464_abnormal_platelet_physiology1.55305844
43MP0003303_peritoneal_inflammation1.54765280
44MP0000490_abnormal_crypts_of1.37192954
45MP0001851_eye_inflammation1.33735330
46MP0008469_abnormal_protein_level1.30402867
47MP0002132_abnormal_respiratory_system1.27271644
48MP0010352_gastrointestinal_tract_polyps1.24235641
49MP0005310_abnormal_salivary_gland1.23437785
50MP0004808_abnormal_hematopoietic_stem1.20067834
51MP0001853_heart_inflammation1.19568370
52MP0002019_abnormal_tumor_incidence1.14257578
53MP0001533_abnormal_skeleton_physiology1.14198060
54MP0003183_abnormal_peptide_metabolism1.12986347
55MP0000465_gastrointestinal_hemorrhage1.11912258
56MP0009763_increased_sensitivity_to1.04924068
57MP0002998_abnormal_bone_remodeling1.01374526
58MP0005076_abnormal_cell_differentiation0.99273089
59MP0004381_abnormal_hair_follicle0.97400281
60MP0008961_abnormal_basal_metabolism0.96496927
61MP0001348_abnormal_lacrimal_gland0.90678625
62MP0001986_abnormal_taste_sensitivity0.90187598
63MP0003950_abnormal_plasma_membrane0.89844102
64MP0001545_abnormal_hematopoietic_system0.84991942
65MP0005397_hematopoietic_system_phenotyp0.84991942
66MP0003045_fibrosis0.84735033
67MP0005023_abnormal_wound_healing0.77793624
68MP0005451_abnormal_body_composition0.76694659
69MP0002009_preneoplasia0.76263179
70MP0002277_abnormal_respiratory_mucosa0.75957519
71MP0003828_pulmonary_edema0.73460739
72MP0000343_altered_response_to0.72766207
73MP0008873_increased_physiological_sensi0.68477243
74MP0001881_abnormal_mammary_gland0.67384888
75MP0002138_abnormal_hepatobiliary_system0.65434317
76MP0000477_abnormal_intestine_morphology0.64745760
77MP0000604_amyloidosis0.63931670
78* MP0000609_abnormal_liver_physiology0.63550434
79MP0005166_decreased_susceptibility_to0.62341837
80MP0005075_abnormal_melanosome_morpholog0.61991591
81MP0003690_abnormal_glial_cell0.61145904
82MP0003453_abnormal_keratinocyte_physiol0.60629703
83MP0000920_abnormal_myelination0.57090239
84MP0003252_abnormal_bile_duct0.57066041
85MP0003091_abnormal_cell_migration0.55463236
86MP0009765_abnormal_xenobiotic_induced0.54112686
87MP0009764_decreased_sensitivity_to0.53033756
88MP0000015_abnormal_ear_pigmentation0.51870287
89MP0009278_abnormal_bone_marrow0.51624657
90MP0002163_abnormal_gland_morphology0.51286918
91MP0001663_abnormal_digestive_system0.49083963
92MP0003191_abnormal_cellular_cholesterol0.48988948
93MP0003077_abnormal_cell_cycle0.48717105
94MP0003795_abnormal_bone_structure0.48611798
95MP0008057_abnormal_DNA_replication0.48155627
96MP0002136_abnormal_kidney_physiology0.47470760
97MP0001216_abnormal_epidermal_layer0.46659490
98MP0003566_abnormal_cell_adhesion0.46631899
99MP0000249_abnormal_blood_vessel0.46231356
100MP0001243_abnormal_dermal_layer0.45432842
101MP0008007_abnormal_cellular_replicative0.44779467
102MP0001191_abnormal_skin_condition0.44344531
103MP0002693_abnormal_pancreas_physiology0.44062686
104MP0008260_abnormal_autophagy0.43764445
105MP0004883_abnormal_blood_vessel0.43175834
106MP0004957_abnormal_blastocyst_morpholog0.42550285
107MP0003943_abnormal_hepatobiliary_system0.41261924
108MP0003172_abnormal_lysosome_physiology0.41106624
109MP0003656_abnormal_erythrocyte_physiolo0.39760629
110MP0001765_abnormal_ion_homeostasis0.39666306
111MP0005381_digestive/alimentary_phenotyp0.39312671
112MP0004142_abnormal_muscle_tone0.38983371
113MP0004130_abnormal_muscle_cell0.38218884
114MP0002822_catalepsy0.37167240
115MP0005390_skeleton_phenotype0.36745820
116MP0000598_abnormal_liver_morphology0.34388125
117MP0000627_abnormal_mammary_gland0.34331094
118MP0010234_abnormal_vibrissa_follicle0.33173020
119MP0005645_abnormal_hypothalamus_physiol0.32683637
120MP0008874_decreased_physiological_sensi0.32299374
121MP0008569_lethality_at_weaning0.31491480

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.62315943
2Abnormality of T cell number (HP:0011839)6.29789253
3Myositis (HP:0100614)5.70713514
4Retrobulbar optic neuritis (HP:0100654)5.57282056
5Optic neuritis (HP:0100653)5.57282056
6Nasal polyposis (HP:0100582)5.39914109
7Orchitis (HP:0100796)4.95795121
8Encephalitis (HP:0002383)4.82113512
9Abnormality of T cells (HP:0002843)4.72185609
10Hemiplegia (HP:0002301)4.52871320
11IgM deficiency (HP:0002850)4.45754296
12Increased density of long bones (HP:0006392)4.43814503
13Abnormality of the nasal mucosa (HP:0000433)4.41548430
14Recurrent bronchitis (HP:0002837)4.37122996
15Severe combined immunodeficiency (HP:0004430)4.30595275
16Elevated erythrocyte sedimentation rate (HP:0003565)4.28543087
17Recurrent fungal infections (HP:0002841)4.23468827
18Hypoproteinemia (HP:0003075)4.14387063
19Recurrent bacterial skin infections (HP:0005406)4.12982002
20Keratoconjunctivitis sicca (HP:0001097)3.99252508
21Combined immunodeficiency (HP:0005387)3.95021495
22Stomatitis (HP:0010280)3.85953042
23Meningitis (HP:0001287)3.80703802
24Chronic otitis media (HP:0000389)3.79493802
25Panhypogammaglobulinemia (HP:0003139)3.69070511
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.65964859
27Recurrent viral infections (HP:0004429)3.63265132
28Recurrent cutaneous fungal infections (HP:0011370)3.61171365
29Chronic mucocutaneous candidiasis (HP:0002728)3.61171365
30Keratoconjunctivitis (HP:0001096)3.59891429
31Eczematoid dermatitis (HP:0000976)3.51009002
32Chronic diarrhea (HP:0002028)3.50881982
33Pulmonary infiltrates (HP:0002113)3.44374889
34Agammaglobulinemia (HP:0004432)3.42216279
35Hemoptysis (HP:0002105)3.41603422
36Abnormality of macrophages (HP:0004311)3.37116944
37Arterial thrombosis (HP:0004420)3.33157364
38Abnormality of the fingertips (HP:0001211)3.32834282
39Gastrointestinal stroma tumor (HP:0100723)3.31040824
40Increased serum ferritin (HP:0003281)3.26038966
41Hypoalbuminemia (HP:0003073)3.19939949
42Abnormal albumin level (HP:0012116)3.19939949
43Vasculitis (HP:0002633)3.17298908
44IgG deficiency (HP:0004315)3.13376992
45Abnormality of eosinophils (HP:0001879)3.10003909
46Abnormality of T cell physiology (HP:0011840)3.09646455
47Tetraplegia (HP:0002445)3.09082358
48Abnormality of the common coagulation pathway (HP:0010990)3.08541812
49Persistence of primary teeth (HP:0006335)3.05253717
50Pustule (HP:0200039)3.05017121
51Increased IgE level (HP:0003212)3.01105073
52Inflammation of the large intestine (HP:0002037)2.99723640
53Pulmonary embolism (HP:0002204)2.89604048
54Gastrointestinal inflammation (HP:0004386)2.88827908
55Autoimmune hemolytic anemia (HP:0001890)2.88741754
56Lymphoma (HP:0002665)2.85541750
57Leukocytosis (HP:0001974)2.85010134
58* Joint swelling (HP:0001386)2.84697993
59Increased CSF protein (HP:0002922)2.84235192
60Lymphopenia (HP:0001888)2.83461837
61Spontaneous hematomas (HP:0007420)2.81057100
62Recurrent gram-negative bacterial infections (HP:0005420)2.77964788
63Abnormality of iron homeostasis (HP:0011031)2.74695923
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.72398646
65Eosinophilia (HP:0001880)2.71989584
66Gastrointestinal infarctions (HP:0005244)2.71304152
67Papilloma (HP:0012740)2.69774275
68Verrucae (HP:0200043)2.69774275
69IgA deficiency (HP:0002720)2.69224124
70Thyroiditis (HP:0100646)2.62084397
71Urticaria (HP:0001025)2.57218093
72Abnormality of B cell number (HP:0010975)2.52509719
73B lymphocytopenia (HP:0010976)2.52509719
74Autoimmune thrombocytopenia (HP:0001973)2.49709906
75Gangrene (HP:0100758)2.49458978
76Mediastinal lymphadenopathy (HP:0100721)2.47181808
77Bronchitis (HP:0012387)2.41575244
78Anorexia (HP:0002039)2.38310362
79Emphysema (HP:0002097)2.36321305
80Hypochromic anemia (HP:0001931)2.34279997
81Granulocytopenia (HP:0001913)2.34134656
82Cellulitis (HP:0100658)2.33113688
83Chest pain (HP:0100749)2.27812699
84Abnormality of transition element cation homeostasis (HP:0011030)2.27639107
85Gingivitis (HP:0000230)2.26184164
86Papilledema (HP:0001085)2.23594492
87Recurrent abscess formation (HP:0002722)2.19458783
88Chronic obstructive pulmonary disease (HP:0006510)2.19362908
89Obstructive lung disease (HP:0006536)2.19362908
90Ureteral stenosis (HP:0000071)2.19350410
91Abnormality of the prostate (HP:0008775)2.11280045
92Premature loss of primary teeth (HP:0006323)2.11219931
93Recurrent skin infections (HP:0001581)2.10815172
94Restrictive lung disease (HP:0002091)2.10184448
95Cheilitis (HP:0100825)2.10109973
96Stomach cancer (HP:0012126)2.09457481
97Abnormal platelet volume (HP:0011876)2.09426410
98Recurrent sinusitis (HP:0011108)2.09168717
99Increased IgM level (HP:0003496)2.08787140
100Hypergammaglobulinemia (HP:0010702)2.08738479
101Abnormality of the endocardium (HP:0004306)2.02730907
102Hypoplasia of the thymus (HP:0000778)2.02209904
103Keratitis (HP:0000491)2.00846841
104Osteomyelitis (HP:0002754)2.00190916
105Epistaxis (HP:0000421)2.00107087
106Abnormality of the pleura (HP:0002103)2.00093315
107Basal cell carcinoma (HP:0002671)1.99777786
108Glomerulopathy (HP:0100820)1.99354417
109Skin ulcer (HP:0200042)1.98851619
110* Arthralgia (HP:0002829)1.98759075
111Increased intracranial pressure (HP:0002516)1.97693588
112Abnormality of intracranial pressure (HP:0012640)1.97693588
113Ureteral obstruction (HP:0006000)1.97693577
114Alveolar cell carcinoma (HP:0006519)1.96263870
115Prolonged bleeding time (HP:0003010)1.94768170
116Sepsis (HP:0100806)1.94018727
117Hypertriglyceridemia (HP:0002155)1.93837685
118Bilateral sensorineural hearing impairment (HP:0008619)1.93108761
119Hyponatremia (HP:0002902)1.91417802
120Thrombocytosis (HP:0001894)1.90263473
121Gingival bleeding (HP:0000225)1.88815204
122Chronic sinusitis (HP:0011109)1.87400977
123Colitis (HP:0002583)1.86368031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.62432053
2MAP4K15.11015840
3JAK33.45635505
4ITK3.32027469
5RIPK43.25023724
6PRPF4B3.10032992
7STK102.77483874
8FGFR42.70806856
9ZAP702.58086338
10TYK22.40902191
11GRK72.09489027
12GRK61.93703951
13* JAK11.87275989
14IKBKE1.85341750
15FGFR31.83280679
16MAP3K141.81257777
17EEF2K1.77688426
18EPHB11.71185877
19* LCK1.64706513
20TAOK31.59829880
21CSK1.52185024
22EPHA31.50701909
23NLK1.45639959
24MST41.45169246
25MAP3K101.43764502
26TBK11.42500977
27TRIB31.41211144
28ERN11.39635897
29IRAK31.39204637
30TEC1.37405192
31PRKCH1.34817526
32BTK1.33679363
33HCK1.29124404
34PRKCQ1.27244207
35KDR1.27127329
36BMPR21.26928401
37PIM11.23047297
38CDK121.21925899
39SYK1.19614596
40SIK21.18820414
41ADRBK21.18499776
42FES1.17717047
43TESK21.16047106
44MAP2K21.11593854
45MARK31.07065519
46CDK41.01242306
47JAK20.97897438
48LRRK20.96154663
49KIT0.93169430
50PKN20.89986873
51TNK20.87879904
52MAP3K70.87114702
53FGR0.86705759
54RPS6KA40.86582450
55MAP3K130.86299222
56IKBKB0.83987646
57TLK10.82443897
58TTN0.79209645
59BLK0.78835611
60CLK10.77825449
61ALK0.72886590
62SMG10.72825321
63CHUK0.69240931
64TYRO30.68547550
65MAPK120.68521414
66LYN0.65725578
67MAPK70.63461189
68CDC42BPA0.63294239
69SIK30.60785801
70TSSK60.60709108
71BRD40.59036431
72PDGFRB0.58166562
73FGFR10.57538216
74MOS0.57268828
75TAOK10.57034201
76MATK0.53749521
77TGFBR20.53732095
78DMPK0.51866800
79MELK0.50578288
80SIK10.50453553
81IRAK40.50429481
82CAMKK10.49350916
83HIPK20.49333334
84CAMKK20.48170697
85MAP3K110.47376551
86IRAK10.47020853
87PTK60.46190554
88EIF2AK20.44910551
89PDK10.44902004
90STK240.44411249
91RIPK10.43773163
92CDK60.43271889
93CDK30.42390700
94CDK90.40975117
95MAP3K10.40677922
96FYN0.39397378
97CSF1R0.39157492
98MAP3K30.38317562
99MARK20.38178584
100MAP2K60.37898413
101TAOK20.37726741
102MAP3K80.35852986
103GSK3A0.31206418
104PIK3CG0.30564660
105PDPK10.30319012
106NEK20.30311646
107PRKD20.29792495
108KSR20.28675711
109BMX0.28047546
110MAP2K30.27339193
111RPS6KL10.26540762
112RPS6KC10.26540762
113RET0.26467816
114* IGF1R0.26343137
115ABL10.24212361
116SGK30.24135107
117RPS6KA60.23912369
118MAPKAPK20.23297001
119YES10.22727083
120MAPK110.22711660
121* INSR0.22153472
122MAPK40.21647893
123STK110.20845143
124NEK60.20259349
125TRPM70.20137907
126PASK0.19235695
127RPS6KA50.18585375
128EGFR0.18215926
129NUAK10.17658800
130MAPK30.17463401
131SRC0.15282528

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053326.07529971
2Allograft rejection_Homo sapiens_hsa053304.59320714
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.14978701
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.99638754
5Primary immunodeficiency_Homo sapiens_hsa053403.93099944
6Autoimmune thyroid disease_Homo sapiens_hsa053203.57531571
7Type I diabetes mellitus_Homo sapiens_hsa049403.17203790
8T cell receptor signaling pathway_Homo sapiens_hsa046603.15143202
9Antigen processing and presentation_Homo sapiens_hsa046122.65457730
10Viral myocarditis_Homo sapiens_hsa054162.50337516
11* Measles_Homo sapiens_hsa051622.19805460
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.07305854
13Osteoclast differentiation_Homo sapiens_hsa043801.80724541
14* Jak-STAT signaling pathway_Homo sapiens_hsa046301.79112043
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.78854717
16Leishmaniasis_Homo sapiens_hsa051401.65289722
17B cell receptor signaling pathway_Homo sapiens_hsa046621.55293662
18Hematopoietic cell lineage_Homo sapiens_hsa046401.47416887
19Toxoplasmosis_Homo sapiens_hsa051451.38150919
20Apoptosis_Homo sapiens_hsa042101.30237534
21Chemokine signaling pathway_Homo sapiens_hsa040621.23252872
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.22985799
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18069133
24Acute myeloid leukemia_Homo sapiens_hsa052211.13261324
25TNF signaling pathway_Homo sapiens_hsa046681.13058453
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11055311
27Shigellosis_Homo sapiens_hsa051311.06320548
28Hepatitis B_Homo sapiens_hsa051611.06051798
29Herpes simplex infection_Homo sapiens_hsa051681.04655558
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03810108
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02809131
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99444909
33Pancreatic cancer_Homo sapiens_hsa052120.98924016
34Malaria_Homo sapiens_hsa051440.98016775
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95719828
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94623206
37* HTLV-I infection_Homo sapiens_hsa051660.93874331
38Chronic myeloid leukemia_Homo sapiens_hsa052200.89499679
39VEGF signaling pathway_Homo sapiens_hsa043700.89324822
40Prolactin signaling pathway_Homo sapiens_hsa049170.88455070
41Influenza A_Homo sapiens_hsa051640.87795881
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85360207
43Staphylococcus aureus infection_Homo sapiens_hsa051500.85251840
44Epstein-Barr virus infection_Homo sapiens_hsa051690.80298897
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78672597
46Colorectal cancer_Homo sapiens_hsa052100.77804336
47Platelet activation_Homo sapiens_hsa046110.76583614
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74033993
49Viral carcinogenesis_Homo sapiens_hsa052030.70785672
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67615205
51Legionellosis_Homo sapiens_hsa051340.65501482
52African trypanosomiasis_Homo sapiens_hsa051430.64592219
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.63431294
54Renal cell carcinoma_Homo sapiens_hsa052110.62981057
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61808056
56Tuberculosis_Homo sapiens_hsa051520.60545857
57Hepatitis C_Homo sapiens_hsa051600.58710477
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58147270
59Pertussis_Homo sapiens_hsa051330.56961267
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55801325
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55443018
62Salmonella infection_Homo sapiens_hsa051320.55113167
63Asthma_Homo sapiens_hsa053100.54935960
64Phagosome_Homo sapiens_hsa041450.54393696
65Small cell lung cancer_Homo sapiens_hsa052220.51258497
66* Endocytosis_Homo sapiens_hsa041440.49908919
67Non-small cell lung cancer_Homo sapiens_hsa052230.48843999
68p53 signaling pathway_Homo sapiens_hsa041150.44802085
69Rheumatoid arthritis_Homo sapiens_hsa053230.43289862
70MAPK signaling pathway_Homo sapiens_hsa040100.40033759
71* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39437930
72Systemic lupus erythematosus_Homo sapiens_hsa053220.38806038
73Notch signaling pathway_Homo sapiens_hsa043300.36328029
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35701617
75Insulin resistance_Homo sapiens_hsa049310.35423587
76mTOR signaling pathway_Homo sapiens_hsa041500.35138322
77FoxO signaling pathway_Homo sapiens_hsa040680.33414569
78HIF-1 signaling pathway_Homo sapiens_hsa040660.33317003
79Rap1 signaling pathway_Homo sapiens_hsa040150.32451952
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.31324916
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.31268762
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.29329500
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28483668
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27829973
85Other glycan degradation_Homo sapiens_hsa005110.27225619
86MicroRNAs in cancer_Homo sapiens_hsa052060.26038480
87Prostate cancer_Homo sapiens_hsa052150.25220982
88Spliceosome_Homo sapiens_hsa030400.24733008
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23976288
90GnRH signaling pathway_Homo sapiens_hsa049120.22886565
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22666924
92Focal adhesion_Homo sapiens_hsa045100.21183724
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20762995
94Ras signaling pathway_Homo sapiens_hsa040140.20652556
95Proteoglycans in cancer_Homo sapiens_hsa052050.20523685
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19876322
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19453023
98Adherens junction_Homo sapiens_hsa045200.18254813
99Pathways in cancer_Homo sapiens_hsa052000.18154342
100RNA degradation_Homo sapiens_hsa030180.16846978
101Inositol phosphate metabolism_Homo sapiens_hsa005620.16441281
102Endometrial cancer_Homo sapiens_hsa052130.16143525
103Lysine degradation_Homo sapiens_hsa003100.16077044
104Dorso-ventral axis formation_Homo sapiens_hsa043200.15850690
105Circadian rhythm_Homo sapiens_hsa047100.15327574
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14412476
107Choline metabolism in cancer_Homo sapiens_hsa052310.14271321
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13690991
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.13443772
110Type II diabetes mellitus_Homo sapiens_hsa049300.11074954
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09763082
112ABC transporters_Homo sapiens_hsa020100.09201145
113Regulation of autophagy_Homo sapiens_hsa041400.08872874
114mRNA surveillance pathway_Homo sapiens_hsa030150.08772417
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08731743
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.08113264

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