IL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of podosome assembly (GO:0071801)8.82656489
2positive regulation of isotype switching (GO:0045830)8.81105308
3positive regulation of immunoglobulin mediated immune response (GO:0002891)8.47584857
4positive regulation of B cell mediated immunity (GO:0002714)8.47584857
5* regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)8.40085772
6regulation of T cell chemotaxis (GO:0010819)7.93266554
7positive regulation of T cell chemotaxis (GO:0010820)7.93266554
8positive regulation of DNA recombination (GO:0045911)7.49785155
9regulation of interleukin-12 biosynthetic process (GO:0045075)7.32143583
10negative regulation of B cell apoptotic process (GO:0002903)7.24985323
11positive regulation of interleukin-17 production (GO:0032740)6.76530579
12regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)6.46279321
13positive regulation of immunoglobulin production (GO:0002639)6.46104065
14positive regulation of macrophage derived foam cell differentiation (GO:0010744)6.41804821
15regulation of immunoglobulin mediated immune response (GO:0002889)6.41103028
16regulation of vitamin D biosynthetic process (GO:0060556)6.40816836
17regulation of isotype switching (GO:0045191)6.24821783
18regulation of B cell mediated immunity (GO:0002712)6.19742636
19regulation of immunoglobulin production (GO:0002637)5.98280313
20regulation of lymphocyte chemotaxis (GO:1901623)5.91890868
21positive regulation of activated T cell proliferation (GO:0042104)5.88023585
22regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.86848228
23positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.86848228
24myeloid dendritic cell differentiation (GO:0043011)5.72623838
25positive regulation of humoral immune response (GO:0002922)5.72550173
26regulation of vitamin metabolic process (GO:0030656)5.69939182
27positive regulation of T cell cytokine production (GO:0002726)5.44981219
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.05680091
29regulation of chronic inflammatory response (GO:0002676)5.05414742
30activated T cell proliferation (GO:0050798)4.91404447
31myeloid dendritic cell activation (GO:0001773)4.88481748
32GTP biosynthetic process (GO:0006183)4.87042479
33pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)4.86059212
34UMP biosynthetic process (GO:0006222)4.86059212
35pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)4.86059212
36UMP metabolic process (GO:0046049)4.86059212
37regulation of interleukin-17 production (GO:0032660)4.81146124
38cellular response to nicotine (GO:0071316)4.77567408
39tyrosine phosphorylation of STAT protein (GO:0007260)4.70736233
40positive regulation of lymphocyte mediated immunity (GO:0002708)4.69981925
41positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.66396031
42positive regulation of B cell proliferation (GO:0030890)4.65774663
43regulation of B cell apoptotic process (GO:0002902)4.59704578
44extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)4.57362763
45signal transduction in absence of ligand (GO:0038034)4.57362763
46negative regulation of T cell mediated immunity (GO:0002710)4.56356969
47* positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)4.52658316
48positive regulation of interferon-gamma production (GO:0032729)4.52041727
49negative regulation of lymphocyte apoptotic process (GO:0070229)4.49841517
50regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.48726486
51regulation of response to tumor cell (GO:0002834)4.46534772
52positive regulation of response to tumor cell (GO:0002836)4.46534772
53positive regulation of immune response to tumor cell (GO:0002839)4.46534772
54regulation of immune response to tumor cell (GO:0002837)4.46534772
55UTP biosynthetic process (GO:0006228)4.45947485
56pyrimidine ribonucleoside biosynthetic process (GO:0046132)4.39564257
57regulation of activated T cell proliferation (GO:0046006)4.34633808
58regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.30756928
59regulation of memory T cell differentiation (GO:0043380)4.19777798
60pyrimidine ribonucleotide biosynthetic process (GO:0009220)4.19598328
61regulation of gamma-delta T cell differentiation (GO:0045586)4.16595689
62positive regulation of gamma-delta T cell activation (GO:0046645)4.12584646
63positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.10436965
64pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.09341821
65positive regulation of leukocyte mediated immunity (GO:0002705)3.97767107
66UTP metabolic process (GO:0046051)3.96612180
67* regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.92887888
68negative regulation of heart contraction (GO:0045822)3.88528326
69positive regulation of lymphocyte migration (GO:2000403)3.84041722
70negative regulation of blood circulation (GO:1903523)3.83296696
71positive regulation of production of molecular mediator of immune response (GO:0002702)3.82661228
72negative regulation of cytokine production involved in immune response (GO:0002719)3.82552994
73regulation of alpha-beta T cell proliferation (GO:0046640)3.75857296
74positive regulation of dendritic spine development (GO:0060999)3.75313068
75pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.75162089
76positive regulation of tissue remodeling (GO:0034105)3.73923272
77* positive regulation of JAK-STAT cascade (GO:0046427)3.73094797
78positive regulation of cell killing (GO:0031343)3.72778468
79pyrimidine ribonucleotide metabolic process (GO:0009218)3.72635457
80positive regulation of T cell migration (GO:2000406)3.69782968
81T cell proliferation (GO:0042098)3.69766531
82regulation of lymphocyte mediated immunity (GO:0002706)3.67621449
83regulation of gamma-delta T cell activation (GO:0046643)3.66225137
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.66055408
85positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.63766869
86positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.60781702
87regulation of T cell cytokine production (GO:0002724)3.58812021
88regulation of fever generation (GO:0031620)3.57931464
89negative regulation of growth of symbiont in host (GO:0044130)3.57634181
90negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.57634181
91modulation of growth of symbiont involved in interaction with host (GO:0044144)3.57634181
92regulation of growth of symbiont in host (GO:0044126)3.57634181
93positive regulation of T cell mediated cytotoxicity (GO:0001916)3.56665789
94CTP biosynthetic process (GO:0006241)3.56110320
95CTP metabolic process (GO:0046036)3.56110320
96positive regulation of organelle assembly (GO:1902117)3.55213753
97positive regulation of heat generation (GO:0031652)3.50601177
98positive regulation of chemokine biosynthetic process (GO:0045080)3.48644186
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47947554
100positive regulation of natural killer cell mediated immunity (GO:0002717)3.44773001
101positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.44773001
102positive regulation of adaptive immune response (GO:0002821)3.44014317
103lymph node development (GO:0048535)3.42087614
104guanosine-containing compound biosynthetic process (GO:1901070)3.41628488
105signal peptide processing (GO:0006465)3.41622629
106regulation of macrophage derived foam cell differentiation (GO:0010743)3.39197133
107protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)3.35002543
108natural killer cell activation (GO:0030101)3.34758189
109pyrimidine nucleotide biosynthetic process (GO:0006221)3.33929642
110pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.33704610
111negative regulation of alpha-beta T cell activation (GO:0046636)3.33016737
112regulation of dendritic spine development (GO:0060998)3.32771175
113negative regulation of production of molecular mediator of immune response (GO:0002701)3.31600549
114negative regulation of lymphocyte proliferation (GO:0050672)3.23741776
115negative regulation of mononuclear cell proliferation (GO:0032945)3.23741776
116positive regulation of type 2 immune response (GO:0002830)3.23301446
117regulation of production of molecular mediator of immune response (GO:0002700)3.23197121
118negative regulation of leukocyte apoptotic process (GO:2000107)3.22805890
119dendritic cell differentiation (GO:0097028)3.17756930
120negative T cell selection (GO:0043383)3.17095003
121T cell homeostasis (GO:0043029)3.15669352
122regulation of T cell migration (GO:2000404)3.15250794
123positive regulation of astrocyte differentiation (GO:0048711)3.14360234
124regulation of cell killing (GO:0031341)3.12085092
125negative regulation of lymphocyte mediated immunity (GO:0002707)3.10900228
126regulation of DNA recombination (GO:0000018)3.07678499
127ribosome biogenesis (GO:0042254)3.05315227
128pyrimidine nucleoside biosynthetic process (GO:0046134)3.03343779
129pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.03259800
130positive regulation of T cell differentiation (GO:0045582)3.02480294
131regulation of B cell proliferation (GO:0030888)3.02416491
132pyrimidine ribonucleoside metabolic process (GO:0046131)3.02209822
133regulation of interferon-gamma production (GO:0032649)3.01379609
134polarized epithelial cell differentiation (GO:0030859)2.91648731
135pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88268359
136nucleoside diphosphate phosphorylation (GO:0006165)2.88044830
137proteasome assembly (GO:0043248)2.86242075
138positive regulation of B cell activation (GO:0050871)2.85522385
139regulation of inflammatory response to antigenic stimulus (GO:0002861)2.82789069
140negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.81550555
141base-excision repair, AP site formation (GO:0006285)2.80334907
142tRNA aminoacylation (GO:0043039)2.80227746
143amino acid activation (GO:0043038)2.80227746
144response to gravity (GO:0009629)2.79163899
145cellular protein complex localization (GO:0034629)2.76910574
146regulation of lymphocyte apoptotic process (GO:0070228)2.74643395
147cellular response to interleukin-15 (GO:0071350)2.72922756
148interferon-gamma production (GO:0032609)2.71719094
149positive regulation of defense response to virus by host (GO:0002230)2.68137544
150regulation of isotype switching to IgG isotypes (GO:0048302)11.4145503
151regulation of immunoglobulin secretion (GO:0051023)11.0174837
152regulation of regulatory T cell differentiation (GO:0045589)10.5214763
153* positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)10.2631212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.96036406
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.67977944
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.32710665
4E2F7_22180533_ChIP-Seq_HELA_Human4.93776706
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.83210465
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.66377951
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.22476911
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.21609387
9STAT4_19710469_ChIP-ChIP_TH1__Mouse4.17561010
10NOTCH1_21737748_ChIP-Seq_TLL_Human4.09663209
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97111592
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.91448681
13MYC_22102868_ChIP-Seq_BL_Human3.56922641
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52061898
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.50873857
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34687849
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.34216672
18RUNX_20019798_ChIP-Seq_JUKART_Human3.32710499
19ETS1_20019798_ChIP-Seq_JURKAT_Human3.13072965
20EST1_17652178_ChIP-ChIP_JURKAT_Human3.10823332
21MYB_26560356_Chip-Seq_TH2_Human2.89449111
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82884506
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64194853
24FOXP3_21729870_ChIP-Seq_TREG_Human2.60118112
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49511999
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46569239
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45084041
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.37976857
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37735844
30MAF_26560356_Chip-Seq_TH1_Human2.37060866
31SMAD_19615063_ChIP-ChIP_OVARY_Human2.33435605
32MYB_26560356_Chip-Seq_TH1_Human2.29268652
33MYC_18555785_ChIP-Seq_MESCs_Mouse2.27128014
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22564076
35STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22455943
36DCP1A_22483619_ChIP-Seq_HELA_Human2.11054742
37TAF15_26573619_Chip-Seq_HEK293_Human2.08384801
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00013518
39TTF2_22483619_ChIP-Seq_HELA_Human1.99824701
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99073901
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96656853
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.89006542
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87575443
44UTX_26944678_Chip-Seq_JUKART_Human1.87544547
45XRN2_22483619_ChIP-Seq_HELA_Human1.84806220
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81898741
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80718286
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.80562183
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77662134
50MAF_26560356_Chip-Seq_TH2_Human1.77061849
51EGR1_19032775_ChIP-ChIP_M12_Human1.72660372
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70636489
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.70082339
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67485692
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66672924
56TCF7_22412390_ChIP-Seq_EML_Mouse1.64346131
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62860499
58KDM2B_26808549_Chip-Seq_DND41_Human1.62383684
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61086731
60EWS_26573619_Chip-Seq_HEK293_Human1.59277091
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57068349
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55429329
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55407065
64ZNF274_21170338_ChIP-Seq_K562_Hela1.54238756
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54025217
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50946073
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.50212616
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.48311981
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44671487
70VDR_24763502_ChIP-Seq_THP-1_Human1.44521712
71VDR_24787735_ChIP-Seq_THP-1_Human1.39568100
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.38692236
73VDR_21846776_ChIP-Seq_THP-1_Human1.36281312
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35590792
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34725066
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34599480
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.34407842
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34390854
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34175532
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33660056
81ZNF263_19887448_ChIP-Seq_K562_Human1.31574964
82AR_21909140_ChIP-Seq_LNCAP_Human1.30106642
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29964626
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26403630
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25133897
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.24752698
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.20221064
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18988684
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16826680
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.16416691
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16411175
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16124022
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16094434
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15779367
95CLOCK_20551151_ChIP-Seq_293T_Human1.10771981
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.10502388
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10149909
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07583990
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04180406
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03099937
101CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02974087
102ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02812697
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02219424
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02149557
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01587883
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00081447
107* PU_27001747_Chip-Seq_BMDM_Mouse1.00050324
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98694361
109GABP_19822575_ChIP-Seq_HepG2_Human0.97376371
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97326703
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95888723
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95778212
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94239598
114MYC_18940864_ChIP-ChIP_HL60_Human0.94011116
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93849160
116ERA_21632823_ChIP-Seq_H3396_Human0.93457326
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92008354
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91110643
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90675355
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90231728
121TP53_22573176_ChIP-Seq_HFKS_Human0.89939501
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89129458
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88994719
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88994428
125FOXM1_23109430_ChIP-Seq_U2OS_Human0.88777770
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88354174
127CTCF_20526341_ChIP-Seq_ESCs_Human0.88104303
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87707408
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87135175
130NANOG_19829295_ChIP-Seq_ESCs_Human0.87012674
131SOX2_19829295_ChIP-Seq_ESCs_Human0.87012674
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86877810
133SPI1_23547873_ChIP-Seq_NB4_Human0.83434215
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82747402
135ELK1_19687146_ChIP-ChIP_HELA_Human0.82236699
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82068215
137ELF5_23300383_ChIP-Seq_T47D_Human0.81315839
138* GATA3_26560356_Chip-Seq_TH2_Human0.80732631
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80286942
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78946748
141MYC_19030024_ChIP-ChIP_MESCs_Mouse0.78588160
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77439581
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.76417130
144* ELK3_25401928_ChIP-Seq_HUVEC_Human0.75737726
145VDR_23849224_ChIP-Seq_CD4+_Human0.74957979
146ATF3_27146783_Chip-Seq_COLON_Human0.74925315
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.72448792
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.66117846
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65167618
150SMRT_27268052_Chip-Seq_Bcells_Human0.64882442
151* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64507094
152SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63113371
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.62709478
154CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62022230
155* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61684084
156GATA1_19941826_ChIP-Seq_K562_Human0.61635705
157* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61507819
158PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61465329
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60388013
160UBF1/2_26484160_Chip-Seq_HMECs_Human0.60325687
161VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.59860920
162GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.59163742
163KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.58819041
164NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.58373416
165P300_27058665_Chip-Seq_ZR-75-30cells_Human0.57987103
166KDM5A_27292631_Chip-Seq_BREAST_Human0.57701376
167SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.56983835
168NCOR1_26117541_ChIP-Seq_K562_Human0.56936083
169RACK7_27058665_Chip-Seq_MCF-7_Human0.56774748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer8.58834492
2MP0001835_abnormal_antigen_presentation5.38144620
3MP0000604_amyloidosis4.89331890
4MP0005671_abnormal_response_to4.78332625
5MP0001853_heart_inflammation4.76523171
6MP0000465_gastrointestinal_hemorrhage4.67219992
7MP0004782_abnormal_surfactant_physiolog3.71239384
8MP0003436_decreased_susceptibility_to3.48006914
9MP0000685_abnormal_immune_system3.46521190
10MP0003763_abnormal_thymus_physiology3.18908289
11MP0001958_emphysema3.18168431
12MP0009333_abnormal_splenocyte_physiolog3.12767465
13MP0002405_respiratory_system_inflammati3.11209088
14MP0003303_peritoneal_inflammation2.86748876
15MP0003866_abnormal_defecation2.27850816
16MP0006082_CNS_inflammation2.22405151
17MP0009785_altered_susceptibility_to2.21609748
18MP0005000_abnormal_immune_tolerance2.18603798
19MP0001873_stomach_inflammation2.11765882
20MP0001800_abnormal_humoral_immune2.07349964
21MP0001790_abnormal_immune_system1.97780393
22MP0005387_immune_system_phenotype1.97780393
23MP0002398_abnormal_bone_marrow1.74689160
24MP0002723_abnormal_immune_serum1.70460313
25MP0004510_myositis1.64249716
26MP0001881_abnormal_mammary_gland1.61092349
27MP0003786_premature_aging1.58184162
28MP0001501_abnormal_sleep_pattern1.54922168
29MP0002420_abnormal_adaptive_immunity1.53984379
30MP0008057_abnormal_DNA_replication1.53935640
31MP0010155_abnormal_intestine_physiology1.53655247
32MP0001819_abnormal_immune_cell1.50441708
33MP0000689_abnormal_spleen_morphology1.50439743
34MP0002166_altered_tumor_susceptibility1.46709296
35MP0006292_abnormal_olfactory_placode1.45459822
36MP0000703_abnormal_thymus_morphology1.41580292
37* MP0005025_abnormal_response_to1.39410797
38MP0003329_amyloid_beta_deposits1.37832573
39MP0002722_abnormal_immune_system1.37160228
40MP0002396_abnormal_hematopoietic_system1.36128496
41MP0001845_abnormal_inflammatory_respons1.33361053
42MP0002452_abnormal_antigen_presenting1.31040533
43MP0000716_abnormal_immune_system1.28587130
44MP0010307_abnormal_tumor_latency1.26333339
45MP0004808_abnormal_hematopoietic_stem1.26178977
46MP0001533_abnormal_skeleton_physiology1.25752747
47MP0004147_increased_porphyrin_level1.17139835
48MP0002736_abnormal_nociception_after1.12671912
49MP0002429_abnormal_blood_cell1.10572435
50MP0002006_tumorigenesis1.09027315
51MP0002419_abnormal_innate_immunity1.08652635
52MP0004947_skin_inflammation1.01692061
53MP0004145_abnormal_muscle_electrophysio1.00145318
54* MP0002148_abnormal_hypersensitivity_rea0.99225217
55MP0008058_abnormal_DNA_repair0.97241089
56MP0004885_abnormal_endolymph0.93766443
57MP0002933_joint_inflammation0.90670768
58MP0008872_abnormal_physiological_respon0.89644229
59MP0003448_altered_tumor_morphology0.88304067
60MP0002234_abnormal_pharynx_morphology0.85944776
61MP0000609_abnormal_liver_physiology0.84910402
62MP0003718_maternal_effect0.84160158
63MP0000627_abnormal_mammary_gland0.79523863
64MP0005165_increased_susceptibility_to0.77475660
65MP0005076_abnormal_cell_differentiation0.74735728
66MP0005166_decreased_susceptibility_to0.74215106
67MP0003646_muscle_fatigue0.72692508
68MP0001968_abnormal_touch/_nociception0.72195730
69MP0009764_decreased_sensitivity_to0.72032805
70MP0001663_abnormal_digestive_system0.71859423
71MP0005670_abnormal_white_adipose0.71619565
72MP0002693_abnormal_pancreas_physiology0.71610036
73MP0002138_abnormal_hepatobiliary_system0.71320573
74MP0004742_abnormal_vestibular_system0.68513450
75MP0008961_abnormal_basal_metabolism0.66040537
76MP0002132_abnormal_respiratory_system0.66040168
77MP0002277_abnormal_respiratory_mucosa0.65625178
78MP0002019_abnormal_tumor_incidence0.65048637
79MP0001727_abnormal_embryo_implantation0.63902892
80MP0005448_abnormal_energy_balance0.63617932
81MP0003724_increased_susceptibility_to0.63398987
82MP0008260_abnormal_autophagy0.62286237
83MP0004264_abnormal_extraembryonic_tissu0.60871766
84MP0000249_abnormal_blood_vessel0.60654505
85MP0002837_dystrophic_cardiac_calcinosis0.60376962
86MP0005390_skeleton_phenotype0.60276343
87MP0003806_abnormal_nucleotide_metabolis0.59885665
88MP0005645_abnormal_hypothalamus_physiol0.58353740
89MP0005464_abnormal_platelet_physiology0.56532180
90MP0005636_abnormal_mineral_homeostasis0.55877866
91MP0002998_abnormal_bone_remodeling0.55761144
92MP0005310_abnormal_salivary_gland0.55565398
93MP0004142_abnormal_muscle_tone0.54779510
94MP0000490_abnormal_crypts_of0.53705708
95MP0003878_abnormal_ear_physiology0.52599743
96MP0005377_hearing/vestibular/ear_phenot0.52599743
97MP0001502_abnormal_circadian_rhythm0.52104644
98MP0008469_abnormal_protein_level0.52029099
99MP0003795_abnormal_bone_structure0.52029076
100MP0002938_white_spotting0.51795366
101MP0004197_abnormal_fetal_growth/weight/0.51016931
102MP0004036_abnormal_muscle_relaxation0.50915899
103MP0003453_abnormal_keratinocyte_physiol0.49498985
104MP0001919_abnormal_reproductive_system0.48064545
105MP0001440_abnormal_grooming_behavior0.47773242
106MP0003045_fibrosis0.47442005
107MP0005423_abnormal_somatic_nervous0.47367041
108MP0009765_abnormal_xenobiotic_induced0.45975839
109MP0009697_abnormal_copulation0.45542869
110MP0003656_abnormal_erythrocyte_physiolo0.44295288
111MP0001348_abnormal_lacrimal_gland0.43762108
112MP0001851_eye_inflammation0.41504670
113MP0004957_abnormal_blastocyst_morpholog0.41264052
114MP0004381_abnormal_hair_follicle0.39791717
115MP0005647_abnormal_sex_gland0.39688075
116MP0005381_digestive/alimentary_phenotyp0.38664598
117MP0003693_abnormal_embryo_hatching0.38299644
118MP0000858_altered_metastatic_potential0.38077257
119MP0009763_increased_sensitivity_to0.36739621
120MP0002254_reproductive_system_inflammat0.36724285
121MP0004133_heterotaxia0.36574194
122MP0000678_abnormal_parathyroid_gland0.36446098
123MP0005389_reproductive_system_phenotype0.35437313
124MP0001485_abnormal_pinna_reflex0.35305585
125MP0008569_lethality_at_weaning0.34758676
126MP0005388_respiratory_system_phenotype0.32656143
127MP0002133_abnormal_respiratory_system0.32656143
128MP0000598_abnormal_liver_morphology0.32551554
129MP0004270_analgesia0.32192180
130MP0008875_abnormal_xenobiotic_pharmacok0.31193070
131MP0002136_abnormal_kidney_physiology0.30963348
132MP0001545_abnormal_hematopoietic_system0.30046365
133MP0005397_hematopoietic_system_phenotyp0.30046365
134MP0003936_abnormal_reproductive_system0.29600680
135MP0005395_other_phenotype0.29391027
136MP0000350_abnormal_cell_proliferation0.28822732
137MP0003705_abnormal_hypodermis_morpholog0.28584328
138MP0003633_abnormal_nervous_system0.26488846
139MP0002089_abnormal_postnatal_growth/wei0.26373553
140MP0003091_abnormal_cell_migration0.24314655
141MP0003077_abnormal_cell_cycle0.22188533

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)8.16977777
2Increased IgM level (HP:0003496)6.57786947
3T lymphocytopenia (HP:0005403)6.22525050
4Persistence of primary teeth (HP:0006335)6.18361977
5Abnormality of T cell number (HP:0011839)6.08472963
6IgA deficiency (HP:0002720)5.75833263
7Gastrointestinal infarctions (HP:0005244)5.62174147
8Thrombocytosis (HP:0001894)5.22707137
9Abnormality of T cells (HP:0002843)4.96799645
10Acute necrotizing encephalopathy (HP:0006965)4.75611487
11Microvesicular hepatic steatosis (HP:0001414)4.58882083
12Elevated erythrocyte sedimentation rate (HP:0003565)4.53915373
13Acute encephalopathy (HP:0006846)4.40190106
14Nasal polyposis (HP:0100582)4.22155811
15Arterial thrombosis (HP:0004420)4.14517389
16Abnormal mitochondria in muscle tissue (HP:0008316)4.13225345
173-Methylglutaconic aciduria (HP:0003535)4.11985741
18Fatigue (HP:0012378)4.09596011
19Amaurosis fugax (HP:0100576)4.05865077
20Poor speech (HP:0002465)4.02016856
21Myocardial infarction (HP:0001658)3.95381908
22Progressive macrocephaly (HP:0004481)3.90241475
23Abnormality of T cell physiology (HP:0011840)3.83836870
24IgG deficiency (HP:0004315)3.81509736
25Dyschromatopsia (HP:0007641)3.77403964
26Peritonitis (HP:0002586)3.77400506
27Polycythemia (HP:0001901)3.60845650
28Increased hepatocellular lipid droplets (HP:0006565)3.56343143
29Severe combined immunodeficiency (HP:0004430)3.53348541
30Abnormality of the peritoneum (HP:0002585)3.50569782
31Abnormality of the nasal mucosa (HP:0000433)3.47112609
32Chest pain (HP:0100749)3.46248941
33Joint swelling (HP:0001386)3.43693751
34Eczematoid dermatitis (HP:0000976)3.37832435
35Spontaneous abortion (HP:0005268)3.31720711
36Recurrent viral infections (HP:0004429)3.20602898
37Abnormality of the anterior horn cell (HP:0006802)3.15314445
38Degeneration of anterior horn cells (HP:0002398)3.15314445
39Chronic diarrhea (HP:0002028)3.13390530
40Acute myeloid leukemia (HP:0004808)3.11739092
41Recurrent fungal infections (HP:0002841)3.11633335
42Abnormal pupillary function (HP:0007686)3.11052263
43Esophageal varix (HP:0002040)3.09380710
44Absent rod-and cone-mediated responses on ERG (HP:0007688)3.08816872
45Neoplasm of the peripheral nervous system (HP:0100007)3.08503420
46Cerebral hemorrhage (HP:0001342)3.06834432
47Mitochondrial inheritance (HP:0001427)3.06691251
48Combined immunodeficiency (HP:0005387)3.03209232
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98691220
50Congenital, generalized hypertrichosis (HP:0004540)2.93393265
51Lipid accumulation in hepatocytes (HP:0006561)2.90919269
52Increased CSF lactate (HP:0002490)2.90465228
53Mediastinal lymphadenopathy (HP:0100721)2.88144182
54Hepatocellular necrosis (HP:0001404)2.86459812
55Constricted visual fields (HP:0001133)2.78797923
56Somatic mutation (HP:0001428)2.78256198
57Abnormality of B cell number (HP:0010975)2.77855317
58B lymphocytopenia (HP:0010976)2.77855317
59Bicuspid aortic valve (HP:0001647)2.77313606
60Chronic sinusitis (HP:0011109)2.74272052
61Panhypogammaglobulinemia (HP:0003139)2.72621303
62Gingival bleeding (HP:0000225)2.72251362
63Peripheral hypomyelination (HP:0007182)2.70732295
64Thrombophlebitis (HP:0004418)2.69901766
65Diplopia (HP:0000651)2.64720911
66Abnormality of binocular vision (HP:0011514)2.64720911
67Cerebral edema (HP:0002181)2.63512346
68Oral leukoplakia (HP:0002745)2.62071024
69Exertional dyspnea (HP:0002875)2.60809524
70Acute lymphatic leukemia (HP:0006721)2.58232193
71Chronic otitis media (HP:0000389)2.56867818
72Optic disc pallor (HP:0000543)2.55693596
73Recurrent bronchitis (HP:0002837)2.54649549
74Hypergammaglobulinemia (HP:0010702)2.52976778
75Abnormality of the nasal septum (HP:0000419)2.52649474
76Type 2 muscle fiber atrophy (HP:0003554)2.50335985
77Exercise intolerance (HP:0003546)2.50250099
78Hepatitis (HP:0012115)2.49691884
79Abnormal biliary tract physiology (HP:0012439)2.48325929
80Bile duct proliferation (HP:0001408)2.48325929
81Sensorimotor neuropathy (HP:0007141)2.45719797
82Acute hepatic failure (HP:0006554)2.44479486
83Anorexia (HP:0002039)2.42676672
84Hepatosplenomegaly (HP:0001433)2.36672105
85Testicular atrophy (HP:0000029)2.35942539
86Leukodystrophy (HP:0002415)2.34163104
87Gingivitis (HP:0000230)2.31441596
88Premature loss of primary teeth (HP:0006323)2.30038013
89Rib fusion (HP:0000902)2.27596777
90Thoracolumbar scoliosis (HP:0002944)2.26910378
91Hepatic necrosis (HP:0002605)2.26251715
92Muscle fiber atrophy (HP:0100295)2.26063296
93Renal Fanconi syndrome (HP:0001994)2.23131268
94Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22471452
95Leukocytosis (HP:0001974)2.21492738
96Nephronophthisis (HP:0000090)2.20280699
97Pulmonary infiltrates (HP:0002113)2.19303425
98Dysmetric saccades (HP:0000641)2.18871544
99Limb hypertonia (HP:0002509)2.16193780
100Back pain (HP:0003418)2.15735137
101Delayed myelination (HP:0012448)2.13993224
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13785885
103Portal hypertension (HP:0001409)2.13312894
104Paralysis (HP:0003470)2.12365803
105Horseshoe kidney (HP:0000085)2.11210727
106Vertebral fusion (HP:0002948)2.06505980
107Septate vagina (HP:0001153)2.05915875
108Nausea (HP:0002018)2.04218154
109Abnormality of the ileum (HP:0001549)2.03675665
110Hypoplasia of the pons (HP:0012110)2.02077079
111Lymphoma (HP:0002665)2.01912777
112Premature graying of hair (HP:0002216)2.00997904
113Stomatitis (HP:0010280)10.9262902
114Submucous cleft hard palate (HP:0000176)1.99247827
115Pulmonary embolism (HP:0002204)1.99017189
116Meckel diverticulum (HP:0002245)1.98768692
117Fibular aplasia (HP:0002990)1.97775655
118Aplastic anemia (HP:0001915)1.95300652
1192-3 toe syndactyly (HP:0004691)1.95057962
120Abnormal number of incisors (HP:0011064)1.94947035
121Aplasia/hypoplasia of the uterus (HP:0008684)1.94108113
122Abnormality of the hepatic vasculature (HP:0006707)1.93835926
123Broad face (HP:0000283)1.92867094
124Megalencephaly (HP:0001355)1.91627614
125Mitral valve prolapse (HP:0001634)1.90253468
126Vasculitis (HP:0002633)1.90189390
127Upper limb muscle weakness (HP:0003484)1.89690470
128Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88390214
129Abnormality of the neuromuscular junction (HP:0003398)1.88207836
130Fatigable weakness (HP:0003473)1.88207836
131Abnormality of the pons (HP:0007361)1.87512830
132Increased intramyocellular lipid droplets (HP:0012240)1.87113475
133Respiratory difficulties (HP:0002880)1.86987558
134Spinal cord compression (HP:0002176)1.85985814
135Depressed nasal tip (HP:0000437)1.85869708
136Methylmalonic acidemia (HP:0002912)1.84179055
137Duplicated collecting system (HP:0000081)1.81450145
138Sensory axonal neuropathy (HP:0003390)1.80835579
139Acrocyanosis (HP:0001063)1.78947347
140Urinary urgency (HP:0000012)1.78694751
141Myositis (HP:0100614)1.77972466
142Exercise-induced muscle cramps (HP:0003710)1.77314958
143Arthralgia (HP:0002829)1.77012272
144Abnormality of the carotid arteries (HP:0005344)1.76766661
145Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76068022
146Abnormal delayed hypersensitivity skin test (HP:0002963)1.75469016
147Abnormality of the renal medulla (HP:0100957)1.75392430
148Delayed CNS myelination (HP:0002188)1.75000860
149Pancytopenia (HP:0001876)1.74675413
150Abnormal autonomic nervous system physiology (HP:0012332)1.73333391
151Absent thumb (HP:0009777)1.72546040
152Rhinitis (HP:0012384)1.72371290
153Abnormal rod and cone electroretinograms (HP:0008323)1.71631813
154Impaired smooth pursuit (HP:0007772)1.70780681
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.70437163
156Epistaxis (HP:0000421)1.69273794
157Lymphopenia (HP:0001888)1.69227549
158Optic neuritis (HP:0100653)1.68331486
159Retrobulbar optic neuritis (HP:0100654)1.68331486
160Abnormality of primary teeth (HP:0006481)1.63414450
161Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62118564
162Entropion (HP:0000621)1.60173656
163Abnormality of the prostate (HP:0008775)1.59388827
164Pallor (HP:0000980)1.59360447
165Porencephaly (HP:0002132)1.58693723
166Oligodontia (HP:0000677)1.58511511
167Neoplasm of the tracheobronchial system (HP:0100552)1.56424406
168Hammertoe (HP:0001765)1.56337311
169Abnormal platelet volume (HP:0011876)1.55026173
170Vertigo (HP:0002321)1.54665245
171Scanning speech (HP:0002168)1.54173073
172Gangrene (HP:0100758)1.53346585
173Eosinophilia (HP:0001880)1.53151530
174Migraine (HP:0002076)1.52372539
175Alveolar cell carcinoma (HP:0006519)1.51436095
176Abnormality of the Achilles tendon (HP:0005109)1.50332630
177Achilles tendon contracture (HP:0001771)1.50028472
178Increased mean platelet volume (HP:0011877)1.49573689
179Gastrointestinal stroma tumor (HP:0100723)1.48707367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.88927072
2MAP4K16.16368653
3PAK44.89169038
4TRIM284.70421187
5MAPKAPK34.57514195
6SIK34.13867135
7JAK34.03282443
8ZAP703.72549057
9MAP3K143.22115017
10TAOK12.99008301
11ITK2.89822743
12MAP3K112.68546367
13PIM22.63589370
14TAOK22.39049803
15SIK12.32020155
16CHUK2.13121787
17NME12.12724982
18IKBKB2.04689897
19MAP2K31.89688277
20EEF2K1.89041982
21MAP3K31.82417124
22MAP3K71.79616469
23MAP3K41.78996093
24MST1R1.78189136
25TEC1.72835816
26CSK1.62498434
27GRK11.59524858
28NEK11.56623987
29ADRBK21.47169502
30DAPK11.42859237
31NME21.30340669
32ALK1.22832109
33LCK1.20857409
34PRKD31.19251721
35EIF2AK21.18995367
36ICK1.17807620
37CSNK1A1L1.16451405
38RAF11.14518229
39TRIB31.13804667
40TSSK61.12974022
41PIM11.10760040
42BUB11.09497866
43BTK1.08929637
44HCK1.08222168
45ATR1.07720425
46SYK1.07594507
47NTRK21.06535766
48PAK21.04134790
49RPS6KA41.00088057
50JAK20.99322033
51TBK10.97614602
52FGFR40.95643572
53STK100.93095991
54MARK30.92645984
55FGFR10.88258957
56MAP3K80.87459267
57IKBKE0.86196136
58RPS6KA60.85213739
59TYK20.84488990
60MAP3K130.80514116
61CSNK1G30.78359150
62PRKCH0.76876050
63PKN20.76110965
64FES0.75907845
65PAK30.75794780
66RPS6KC10.75505193
67RPS6KL10.75505193
68BMPR20.73954628
69EIF2AK30.71787654
70PRKCQ0.71203742
71MAP3K50.70585004
72CDK120.70078106
73PRKCG0.68796955
74ACVR1B0.66646919
75TYRO30.66348095
76RPS6KA50.66273648
77ROCK20.65934776
78WNK40.65662518
79MST40.64169079
80PLK10.62775142
81PHKG20.62455306
82PHKG10.62455306
83GSK3A0.61905719
84MAP3K10.61093544
85PASK0.60659081
86ZAK0.59546931
87MAP3K100.58367707
88JAK10.57592204
89LRRK20.57545384
90VRK10.57440923
91MELK0.56249836
92FGFR30.55912243
93LYN0.54828404
94TLK10.54267658
95RPS6KA10.53375505
96CSNK1G10.52206423
97ERBB40.50818504
98DYRK20.50066499
99EPHB10.49480672
100SRPK10.47392258
101WNK30.47363599
102PDGFRB0.47195217
103SCYL20.45696975
104EIF2AK10.42917177
105INSRR0.41592699
106RPS6KB10.41187482
107CHEK10.40654236
108CSNK1G20.40344342
109MKNK20.39694613
110RPS6KB20.38169403
111EPHA30.37808742
112INSR0.36993407
113EGFR0.36491014
114OXSR10.36227983
115TGFBR10.36043511
116PDK10.35568123
117IGF1R0.35334930
118OBSCN0.34227863
119CDK70.33055302
120SIK20.32265730
121CSNK2A10.30923343
122BMX0.30743559
123STK40.29915501
124CDK40.29340768
125BMPR1B0.28715718
126PTK60.28491441
127PLK30.28315677
128UHMK10.27535490
129FRK0.25818012
130ABL10.25518712
131CAMKK20.25402558
132NEK20.24986358
133CSNK1E0.24188630
134PKN10.24001972
135NUAK10.23720242
136WNK10.23287698
137CDK60.22331248
138PRKG20.21899531
139PRKG10.21594781
140CSNK2A20.21339242
141GSK3B0.21090813
142MAPKAPK20.20191935
143NLK0.19912007
144AURKB0.18319893
145MAPK140.18239741
146PRKCB0.16794113
147KIT0.16350775
148TTN0.15883217
149GRK60.15761246
150CLK10.14725647
151PRKACG0.14303155
152KDR0.14122925
153MET0.13833561
154MKNK10.13406950

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053307.92390953
2Graft-versus-host disease_Homo sapiens_hsa053326.39076419
3Type I diabetes mellitus_Homo sapiens_hsa049405.87571408
4Autoimmune thyroid disease_Homo sapiens_hsa053204.63388971
5Proteasome_Homo sapiens_hsa030503.89910278
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.24363984
7T cell receptor signaling pathway_Homo sapiens_hsa046603.13867340
8Basal transcription factors_Homo sapiens_hsa030223.06887861
9Protein export_Homo sapiens_hsa030603.00227877
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.82085929
11* Asthma_Homo sapiens_hsa053102.44416826
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40270476
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.29997081
14* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.93175274
15* Jak-STAT signaling pathway_Homo sapiens_hsa046301.69975999
16Measles_Homo sapiens_hsa051621.65135053
17Primary immunodeficiency_Homo sapiens_hsa053401.59751695
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56686761
19Leishmaniasis_Homo sapiens_hsa051401.44724699
20TNF signaling pathway_Homo sapiens_hsa046681.41011303
21Pyrimidine metabolism_Homo sapiens_hsa002401.39659458
22* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37367094
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34964038
24Regulation of autophagy_Homo sapiens_hsa041401.34341124
25* Hematopoietic cell lineage_Homo sapiens_hsa046401.34272791
26Base excision repair_Homo sapiens_hsa034101.31869352
27Nucleotide excision repair_Homo sapiens_hsa034201.30757426
28Rheumatoid arthritis_Homo sapiens_hsa053231.26806038
29Antigen processing and presentation_Homo sapiens_hsa046121.18793729
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17775427
31Malaria_Homo sapiens_hsa051441.13102029
32Toxoplasmosis_Homo sapiens_hsa051451.07242390
33Salmonella infection_Homo sapiens_hsa051321.01901024
34Dorso-ventral axis formation_Homo sapiens_hsa043201.00929213
35Oxidative phosphorylation_Homo sapiens_hsa001901.00799137
36Osteoclast differentiation_Homo sapiens_hsa043801.00019219
37African trypanosomiasis_Homo sapiens_hsa051430.99188010
38HTLV-I infection_Homo sapiens_hsa051660.97997795
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97757700
40Systemic lupus erythematosus_Homo sapiens_hsa053220.97166194
41Amoebiasis_Homo sapiens_hsa051460.95717713
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92483389
43Herpes simplex infection_Homo sapiens_hsa051680.87392409
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85318048
45Chemokine signaling pathway_Homo sapiens_hsa040620.79087417
46Legionellosis_Homo sapiens_hsa051340.78235676
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77001918
48Viral myocarditis_Homo sapiens_hsa054160.76741277
49Prolactin signaling pathway_Homo sapiens_hsa049170.76711831
50Mismatch repair_Homo sapiens_hsa034300.74123292
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71636842
52Acute myeloid leukemia_Homo sapiens_hsa052210.68209588
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65823036
54Chronic myeloid leukemia_Homo sapiens_hsa052200.64989340
55Hepatitis B_Homo sapiens_hsa051610.61052042
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.60612789
57Mineral absorption_Homo sapiens_hsa049780.59615005
58* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59014425
59Viral carcinogenesis_Homo sapiens_hsa052030.58368363
60Pertussis_Homo sapiens_hsa051330.56115999
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55861045
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55007716
63Parkinsons disease_Homo sapiens_hsa050120.54748902
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.52333032
65Alzheimers disease_Homo sapiens_hsa050100.46787566
66Tuberculosis_Homo sapiens_hsa051520.46579025
67B cell receptor signaling pathway_Homo sapiens_hsa046620.46477555
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45202152
69Sulfur metabolism_Homo sapiens_hsa009200.44478089
70Influenza A_Homo sapiens_hsa051640.44213557
71One carbon pool by folate_Homo sapiens_hsa006700.43979682
72Fanconi anemia pathway_Homo sapiens_hsa034600.42377317
73Epstein-Barr virus infection_Homo sapiens_hsa051690.40587372
74Huntingtons disease_Homo sapiens_hsa050160.39777109
75Fructose and mannose metabolism_Homo sapiens_hsa000510.39187731
76Small cell lung cancer_Homo sapiens_hsa052220.36704486
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33336798
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32419911
79Shigellosis_Homo sapiens_hsa051310.32188751
80RNA transport_Homo sapiens_hsa030130.31493505
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30890389
82Purine metabolism_Homo sapiens_hsa002300.30551667
83MAPK signaling pathway_Homo sapiens_hsa040100.30097093
84* Apoptosis_Homo sapiens_hsa042100.29790411
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28150300
86Pancreatic cancer_Homo sapiens_hsa052120.27963899
87Vitamin digestion and absorption_Homo sapiens_hsa049770.27599179
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26101413
89Spliceosome_Homo sapiens_hsa030400.23225449
90Hepatitis C_Homo sapiens_hsa051600.21572893
91HIF-1 signaling pathway_Homo sapiens_hsa040660.21020461
92MicroRNAs in cancer_Homo sapiens_hsa052060.20058711
93Peroxisome_Homo sapiens_hsa041460.18637189
94Cardiac muscle contraction_Homo sapiens_hsa042600.18501732
95TGF-beta signaling pathway_Homo sapiens_hsa043500.18462910
96Cocaine addiction_Homo sapiens_hsa050300.18418741
97mTOR signaling pathway_Homo sapiens_hsa041500.16092328
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.15756947
99Insulin resistance_Homo sapiens_hsa049310.14827223
100Nicotine addiction_Homo sapiens_hsa050330.14469078
101Circadian rhythm_Homo sapiens_hsa047100.13369926
102Ribosome_Homo sapiens_hsa030100.12725974
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12702682
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.12586783
105Vitamin B6 metabolism_Homo sapiens_hsa007500.11885124
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.10194681
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09640536
108Phototransduction_Homo sapiens_hsa047440.09197116
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08727983
110* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08388198
111Type II diabetes mellitus_Homo sapiens_hsa049300.07844002
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06267196
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.06180665
114VEGF signaling pathway_Homo sapiens_hsa043700.04803115
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.04481229
116Alcoholism_Homo sapiens_hsa050340.03459435
117Colorectal cancer_Homo sapiens_hsa052100.03228970
118Nitrogen metabolism_Homo sapiens_hsa009100.02905955
119Metabolic pathways_Homo sapiens_hsa011000.02785510
120DNA replication_Homo sapiens_hsa030300.02439704
121RNA degradation_Homo sapiens_hsa030180.02166662
122Staphylococcus aureus infection_Homo sapiens_hsa051500.02031829
123mRNA surveillance pathway_Homo sapiens_hsa030150.01513117
124RNA polymerase_Homo sapiens_hsa030200.01116217
125Biosynthesis of amino acids_Homo sapiens_hsa01230-0.0785512
126Renin secretion_Homo sapiens_hsa04924-0.0765539
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964-0.0739784
128N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0687628
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0658721
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0646683
131Taste transduction_Homo sapiens_hsa04742-0.0518863
132Prion diseases_Homo sapiens_hsa05020-0.0513595
133Homologous recombination_Homo sapiens_hsa03440-0.0462341
134PPAR signaling pathway_Homo sapiens_hsa03320-0.0425033
135Retinol metabolism_Homo sapiens_hsa00830-0.0415119
136ErbB signaling pathway_Homo sapiens_hsa04012-0.0373362
137Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0309844
138Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0306609
139Proteoglycans in cancer_Homo sapiens_hsa05205-0.0297813
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0253353
141Platelet activation_Homo sapiens_hsa04611-0.0196278
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666-0.0192191
143Complement and coagulation cascades_Homo sapiens_hsa04610-0.0185421
144Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0179972
145Prostate cancer_Homo sapiens_hsa05215-0.0141648
146Thyroid cancer_Homo sapiens_hsa05216-0.0131299
147Olfactory transduction_Homo sapiens_hsa04740-0.0049188

Most similar genes based on co-expression Upload to Enrichr

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