IL31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of isotype switching (GO:0045830)9.99721952
2reproduction (GO:0000003)9.96690557
3cilium or flagellum-dependent cell motility (GO:0001539)9.93417134
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)9.83545174
5positive regulation of granulocyte differentiation (GO:0030854)9.64993448
6axonemal dynein complex assembly (GO:0070286)9.60601948
7negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.48417413
8cytokine production involved in immune response (GO:0002367)9.39484143
9spermatid development (GO:0007286)9.32983532
10epithelial cilium movement (GO:0003351)9.20109138
11positive regulation of immunoglobulin production (GO:0002639)9.10808908
12positive regulation of chemokine biosynthetic process (GO:0045080)9.07708352
13response to mercury ion (GO:0046689)9.02904963
14CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)8.92652616
15T-helper cell differentiation (GO:0042093)8.92652616
16positive regulation of DNA recombination (GO:0045911)8.78246961
17motile cilium assembly (GO:0044458)8.76172717
18regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)8.73455593
19negative regulation of alpha-beta T cell differentiation (GO:0046639)8.60912032
20negative regulation of acute inflammatory response (GO:0002674)8.58042314
21regulation of MHC class II biosynthetic process (GO:0045346)8.46549241
22regulation of interleukin-13 production (GO:0032656)8.31570165
23regulation of cilium movement (GO:0003352)8.12959434
24alpha-beta T cell differentiation involved in immune response (GO:0002293)7.86719155
25alpha-beta T cell activation involved in immune response (GO:0002287)7.86719155
26T cell differentiation involved in immune response (GO:0002292)7.86719155
27male meiosis (GO:0007140)7.83764032
28cilium movement (GO:0003341)7.77055280
29T cell lineage commitment (GO:0002360)7.69480803
30synaptonemal complex assembly (GO:0007130)7.69049010
31negative regulation of nitric oxide biosynthetic process (GO:0045019)7.63726164
32synaptonemal complex organization (GO:0070193)7.58717057
33single fertilization (GO:0007338)7.52924850
34sperm capacitation (GO:0048240)7.50152991
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.16854546
36piRNA metabolic process (GO:0034587)7.01768807
37regulation of chemokine biosynthetic process (GO:0045073)6.99705273
38regulation of proton transport (GO:0010155)6.96764606
39regulation of immunoglobulin production (GO:0002637)6.60251871
40regulation of isotype switching (GO:0045191)6.51397407
41positive regulation of B cell proliferation (GO:0030890)6.32620126
42spermatogenesis (GO:0007283)6.31862197
43male gamete generation (GO:0048232)6.29579502
44negative regulation of inclusion body assembly (GO:0090084)6.29412510
45fertilization (GO:0009566)6.21765716
46regulation of granulocyte differentiation (GO:0030852)6.17138431
47cytokine biosynthetic process (GO:0042089)6.13391089
48microtubule depolymerization (GO:0007019)6.11545717
49production of molecular mediator of immune response (GO:0002440)6.06240092
50CD4-positive, alpha-beta T cell differentiation (GO:0043367)5.96711890
51organic cation transport (GO:0015695)5.88170733
52gamete generation (GO:0007276)5.81279843
53defense response to protozoan (GO:0042832)5.80755543
54positive regulation of activated T cell proliferation (GO:0042104)5.65480197
55spermatid nucleus differentiation (GO:0007289)5.57151158
56regulation of macrophage activation (GO:0043030)5.55816770
57CD4-positive, alpha-beta T cell activation (GO:0035710)5.49046863
58positive regulation of immunoglobulin mediated immune response (GO:0002891)5.37780814
59positive regulation of B cell mediated immunity (GO:0002714)5.37780814
60negative regulation of alpha-beta T cell activation (GO:0046636)5.33952436
61cellular process involved in reproduction in multicellular organism (GO:0022412)5.33015589
62microtubule severing (GO:0051013)5.27531011
63regulation of inclusion body assembly (GO:0090083)5.23712600
64chromosome organization involved in meiosis (GO:0070192)5.22204223
65calcium ion-dependent exocytosis (GO:0017156)5.21856329
66germ cell development (GO:0007281)5.18209060
67cell recognition (GO:0008037)5.17839771
68kinetochore assembly (GO:0051382)5.10400024
69ventricular system development (GO:0021591)5.04566370
70positive regulation of organelle assembly (GO:1902117)5.02146262
71cytokine metabolic process (GO:0042107)4.96547999
72response to protozoan (GO:0001562)4.92106133
73male meiosis I (GO:0007141)4.86964061
74innate immune response in mucosa (GO:0002227)4.74743542
75chromosome condensation (GO:0030261)4.72076126
76T cell mediated immunity (GO:0002456)4.69249055
77positive regulation of production of molecular mediator of immune response (GO:0002702)4.66717240
78regulation of microtubule-based movement (GO:0060632)4.64869111
79regulation of T-helper cell differentiation (GO:0045622)4.60248221
80multicellular organismal reproductive process (GO:0048609)4.54874140
81positive regulation of JAK-STAT cascade (GO:0046427)4.52751519
82DNA methylation involved in gamete generation (GO:0043046)4.51004009
83meiotic nuclear division (GO:0007126)4.50786598
84DNA packaging (GO:0006323)4.42973955
85monoubiquitinated protein deubiquitination (GO:0035520)4.39233534
86regulation of B cell proliferation (GO:0030888)4.34450737
87positive regulation of B cell activation (GO:0050871)4.32625631
88glycerol ether metabolic process (GO:0006662)4.30287888
89alpha-beta T cell differentiation (GO:0046632)4.27783155
90positive regulation of interleukin-10 production (GO:0032733)4.17905105
91negative regulation of T cell differentiation (GO:0045581)4.11699775
92kinetochore organization (GO:0051383)4.08056486
93seminiferous tubule development (GO:0072520)3.98616728
94signal transduction in absence of ligand (GO:0038034)3.97584794
95extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)3.97584794
96ether metabolic process (GO:0018904)3.96715871
97meiosis I (GO:0007127)3.94871095
98regulation of activated T cell proliferation (GO:0046006)3.93961346
99mucosal immune response (GO:0002385)3.89921751
100negative regulation of osteoclast differentiation (GO:0045671)3.87932901
101protein polyglutamylation (GO:0018095)3.84397726
102negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.80331534
103chaperone-mediated protein complex assembly (GO:0051131)3.78076287
104multicellular organismal development (GO:0007275)3.65565484
105regulation of immunoglobulin mediated immune response (GO:0002889)3.64688686
106alpha-beta T cell activation (GO:0046631)3.64065749
107regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.62192220
108organ or tissue specific immune response (GO:0002251)3.60075322
109single strand break repair (GO:0000012)3.58080347
110regulation of B cell mediated immunity (GO:0002712)3.53393343
111T cell activation involved in immune response (GO:0002286)3.52115294
112left/right pattern formation (GO:0060972)3.51478354
113negative regulation of adaptive immune response (GO:0002820)3.44002286
114regulation of spindle checkpoint (GO:0090231)3.43856836
115protein K11-linked deubiquitination (GO:0035871)3.41692631
116positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.36946782
117sexual reproduction (GO:0019953)3.36937599
118negative regulation of lymphocyte differentiation (GO:0045620)3.35516415
119regulation of JAK-STAT cascade (GO:0046425)3.33288131
120meiotic cell cycle (GO:0051321)3.22206663
121genitalia morphogenesis (GO:0035112)3.21464145
122regulation of production of molecular mediator of immune response (GO:0002700)3.16160277
123microtubule polymerization or depolymerization (GO:0031109)3.16103973
124regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.15265527
125dendritic cell differentiation (GO:0097028)3.06714910
126meiotic cell cycle process (GO:1903046)3.06123330
127regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.05783839
128sequestering of actin monomers (GO:0042989)3.04467460
129positive regulation of macrophage activation (GO:0043032)3.03566794
130protein localization to cilium (GO:0061512)3.00638500
131negative regulation of B cell apoptotic process (GO:0002903)3.00256220
132nucleus organization (GO:0006997)2.99626285
133synapsis (GO:0007129)2.99366785
134amino-acid betaine transport (GO:0015838)2.96918339
135carnitine transport (GO:0015879)2.96918339
136regulation of regulatory T cell differentiation (GO:0045589)2.94808965
137regulation of B cell activation (GO:0050864)2.94460626
138negative regulation of myeloid leukocyte differentiation (GO:0002762)2.85083332
139carnitine transmembrane transport (GO:1902603)2.83754832
140mitotic sister chromatid cohesion (GO:0007064)2.83373279
141regulation of interleukin-10 production (GO:0032653)2.80659381
142regulation of DNA recombination (GO:0000018)2.72535639
143cilium organization (GO:0044782)2.72380711
144positive regulation of interleukin-17 production (GO:0032740)2.71684444
145glycolytic process (GO:0006096)2.68046426
146polyol catabolic process (GO:0046174)2.67882832
147cellular component assembly involved in morphogenesis (GO:0010927)2.67554839
148regulation of immunoglobulin secretion (GO:0051023)2.66174883
149interferon-gamma secretion (GO:0072643)2.65914956
150centriole assembly (GO:0098534)2.65864571
151microtubule-based movement (GO:0007018)2.65448404
152cilium morphogenesis (GO:0060271)2.63779085
153gene silencing by RNA (GO:0031047)2.62131420
154protein refolding (GO:0042026)2.61672006
155intraciliary transport (GO:0042073)2.61286223
156cilium assembly (GO:0042384)2.60392151
157nucleoside diphosphate phosphorylation (GO:0006165)2.59028128
158lymphocyte mediated immunity (GO:0002449)2.56749707
159negative regulation of organelle assembly (GO:1902116)2.54940016
160peptidyl-glutamic acid modification (GO:0018200)2.52718175
161alditol metabolic process (GO:0019400)2.50607968
162axoneme assembly (GO:0035082)2.49485535
163chaperone-mediated protein transport (GO:0072321)2.48517159
164natural killer cell mediated immunity (GO:0002228)2.45801294
165natural killer cell mediated cytotoxicity (GO:0042267)2.45801294
166lactate metabolic process (GO:0006089)2.45330102
167cellular response to oxygen radical (GO:0071450)2.45101144
168removal of superoxide radicals (GO:0019430)2.45101144
169cellular response to superoxide (GO:0071451)2.45101144
170centriole replication (GO:0007099)2.44725654
171regulation of centriole replication (GO:0046599)2.43882031
172protein localization to chromosome, centromeric region (GO:0071459)2.43234835
173positive regulation of lymphocyte mediated immunity (GO:0002708)2.42608070
174estrogen biosynthetic process (GO:0006703)2.42150065
175interferon-gamma production (GO:0032609)2.41535717
176positive regulation of myeloid leukocyte differentiation (GO:0002763)2.40420287
177nuclear pore complex assembly (GO:0051292)2.37759265
178histone exchange (GO:0043486)2.35986363
179GTP biosynthetic process (GO:0006183)2.34052726
180cell wall macromolecule catabolic process (GO:0016998)14.4878239
181cell wall macromolecule metabolic process (GO:0044036)14.4878239
182regulation of isotype switching to IgG isotypes (GO:0048302)14.2350222
183fusion of sperm to egg plasma membrane (GO:0007342)13.8208564
184acrosome assembly (GO:0001675)12.9997880
185sperm motility (GO:0030317)12.8852640
186regulation of podosome assembly (GO:0071801)12.7775334
187sperm-egg recognition (GO:0035036)11.9816093
188CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)11.8998576
189negative regulation of T-helper cell differentiation (GO:0045623)11.8538088
190negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.8538088
191multicellular organism reproduction (GO:0032504)11.8519140
192acrosome reaction (GO:0007340)11.2698741
193regulation of chronic inflammatory response (GO:0002676)11.2078951
194cell-cell recognition (GO:0009988)10.7486435
195plasma membrane fusion (GO:0045026)10.4876472
196binding of sperm to zona pellucida (GO:0007339)10.4799176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.15302798
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.13917059
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12857476
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.41394017
5CREB1_15753290_ChIP-ChIP_HEK293T_Human4.07115598
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.68853045
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.61424393
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57067239
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.31041996
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.19170597
11EZH2_22144423_ChIP-Seq_EOC_Human3.01849229
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.92952829
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.92350512
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.84901035
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67484409
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64754733
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56703877
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.46715682
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42494895
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.41976727
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.40203887
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36327142
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31626078
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22174181
25VDR_22108803_ChIP-Seq_LS180_Human2.21758851
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21697406
27PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19220478
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18786472
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18639887
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.16874495
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14686217
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.13584080
33GATA3_26560356_Chip-Seq_TH2_Human2.06435741
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06283339
35LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05449443
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01570893
37GATA1_26923725_Chip-Seq_HPCs_Mouse2.00035626
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.98425785
39ZNF274_21170338_ChIP-Seq_K562_Hela1.92580616
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.90176355
41FOXP3_21729870_ChIP-Seq_TREG_Human1.84906753
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.83173257
43VDR_23849224_ChIP-Seq_CD4+_Human1.82839540
44STAT1_17558387_ChIP-Seq_HELA_Human1.79757788
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76931965
46ZNF263_19887448_ChIP-Seq_K562_Human1.75429010
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73934407
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.73440716
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73115533
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72147915
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70966219
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.70745282
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68741225
54MYC_18940864_ChIP-ChIP_HL60_Human1.66012315
55RUNX_20019798_ChIP-Seq_JUKART_Human1.65642990
56MYB_26560356_Chip-Seq_TH2_Human1.64417803
57GATA3_21867929_ChIP-Seq_CD8_Mouse1.64121209
58DCP1A_22483619_ChIP-Seq_HELA_Human1.63313858
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.58103228
60KDM2B_26808549_Chip-Seq_REH_Human1.57037485
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56898907
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51985238
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51104510
64EWS_26573619_Chip-Seq_HEK293_Human1.49928328
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49195228
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49187577
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.49084255
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48970035
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46378705
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45839512
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.45054126
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44978915
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.44951055
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.42930819
75* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42330350
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42087690
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40870415
78CBP_20019798_ChIP-Seq_JUKART_Human1.40870415
79TP53_16413492_ChIP-PET_HCT116_Human1.40263038
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39911661
81WDR5_24793694_ChIP-Seq_LNCAP_Human1.38691664
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35263913
83* GATA3_21867929_ChIP-Seq_TH1_Mouse1.34322326
84ELK1_19687146_ChIP-ChIP_HELA_Human1.33946624
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33922824
86TAF15_26573619_Chip-Seq_HEK293_Human1.33798746
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32866832
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32472022
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.30544491
90GF1_26923725_Chip-Seq_HPCs_Mouse1.29718584
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.29218862
92TTF2_22483619_ChIP-Seq_HELA_Human1.28623615
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.28501683
94XRN2_22483619_ChIP-Seq_HELA_Human1.27878662
95RNF2_27304074_Chip-Seq_NSC_Mouse1.26315084
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25469203
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23943744
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.23752637
99CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22208449
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21588901
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21460669
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21354674
103* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19126799
104TP53_22573176_ChIP-Seq_HFKS_Human1.18742124
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.18736418
106SPI1_26923725_Chip-Seq_HPCs_Mouse1.18729165
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.18155694
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18154517
109P53_21459846_ChIP-Seq_SAOS-2_Human1.17716311
110* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17371427
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17214844
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17137984
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16554861
114P53_22387025_ChIP-Seq_ESCs_Mouse1.14941736
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.14179848
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13533130
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13218105
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13149641
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13149641
120P300_18555785_Chip-Seq_ESCs_Mouse1.12714594
121LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12176473
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12126938
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11725032
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11688983
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10587194
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09004378
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08551324
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.08187156
129MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07225451
130PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07164824
131IRF1_19129219_ChIP-ChIP_H3396_Human1.06875986
132* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06748897
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06696052
134FUS_26573619_Chip-Seq_HEK293_Human1.06352439
135SMAD_19615063_ChIP-ChIP_OVARY_Human1.06125478
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06082236
137ERA_21632823_ChIP-Seq_H3396_Human1.05660149
138LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05361707
139REST_21632747_ChIP-Seq_MESCs_Mouse1.05123162
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04521880
141GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04483909
142FLI1_21867929_ChIP-Seq_CD8_Mouse1.04295360
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.04161128
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03763344
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.01702973
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.01366943
147PHF8_20622853_ChIP-Seq_HELA_Human1.00633129
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.99348318
149CTCF_18555785_Chip-Seq_ESCs_Mouse0.98819410
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98009788
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97002973
152PU1_27457419_Chip-Seq_LIVER_Mouse0.96766231
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96445055
154CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95493038
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94181147
156TAF2_19829295_ChIP-Seq_ESCs_Human0.94084065
157* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94002877
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.93392620
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93371449
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.92952944
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92637468
162E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92349936
163* GF1B_26923725_Chip-Seq_HPCs_Mouse0.91775711
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91114427
165SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90898749
166TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90404042
167ERG_20517297_ChIP-Seq_VCAP_Human0.90345876
168STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88972374
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88556889
170CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87024118
171GATA3_26560356_Chip-Seq_TH1_Human0.85258055
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84923031
173ELF5_23300383_ChIP-Seq_T47D_Human0.84271488
174RBPJ_21746931_ChIP-Seq_IB4_Human0.84061487
175PRDM14_20953172_ChIP-Seq_ESCs_Human0.83610040
176BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.83454553
177GATA6_21074721_ChIP-Seq_CACO-2_Human0.83160049
178BCAT_22108803_ChIP-Seq_LS180_Human0.83123294
179* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81495686
180IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81130662
181VDR_24787735_ChIP-Seq_THP-1_Human0.80610191
182RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79866713
183RARB_24833708_ChIP-Seq_LIVER_Mouse0.79223344
184YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77419866
185EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77354935
186STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77345158
187MYC_19079543_ChIP-ChIP_MESCs_Mouse0.77192801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation8.66200039
2MP0003698_abnormal_male_reproductive5.95080513
3MP0001929_abnormal_gametogenesis5.58915786
4MP0008875_abnormal_xenobiotic_pharmacok5.34236210
5MP0008877_abnormal_DNA_methylation4.55882340
6MP0005310_abnormal_salivary_gland4.00488082
7MP0002210_abnormal_sex_determination3.55400800
8MP0008872_abnormal_physiological_respon3.35864128
9MP0002161_abnormal_fertility/fecundity3.24706466
10MP0002653_abnormal_ependyma_morphology3.05092022
11MP0001145_abnormal_male_reproductive2.98339153
12MP0002009_preneoplasia2.76668454
13MP0000653_abnormal_sex_gland2.64071262
14MP0005670_abnormal_white_adipose2.28283586
15MP0005387_immune_system_phenotype2.04345075
16MP0001790_abnormal_immune_system2.04345075
17MP0005410_abnormal_fertilization15.7316432
18MP0001348_abnormal_lacrimal_gland11.3917796
19MP0001663_abnormal_digestive_system1.78260782
20MP0000604_amyloidosis1.65119819
21MP0005000_abnormal_immune_tolerance1.61556276
22MP0005623_abnormal_meninges_morphology1.61159812
23MP0001800_abnormal_humoral_immune1.56762224
24MP0005501_abnormal_skin_physiology1.54686307
25MP0005166_decreased_susceptibility_to1.52634264
26MP0003300_gastrointestinal_ulcer1.49121333
27MP0008058_abnormal_DNA_repair1.46842006
28MP0003646_muscle_fatigue1.41957096
29MP0002166_altered_tumor_susceptibility1.39855886
30MP0005381_digestive/alimentary_phenotyp1.26118015
31MP0002160_abnormal_reproductive_system1.25675874
32MP0009046_muscle_twitch1.24373265
33MP0002148_abnormal_hypersensitivity_rea1.23871092
34MP0004233_abnormal_muscle_weight1.23807955
35MP0000477_abnormal_intestine_morphology1.21863150
36MP0003329_amyloid_beta_deposits1.21353325
37MP0008057_abnormal_DNA_replication1.17536402
38MP0002006_tumorigenesis1.16128656
39MP0002282_abnormal_trachea_morphology1.14314316
40MP0003718_maternal_effect1.08231844
41MP0001765_abnormal_ion_homeostasis1.05870144
42MP0005025_abnormal_response_to1.04380792
43MP0001984_abnormal_olfaction1.01755367
44MP0002277_abnormal_respiratory_mucosa0.99818321
45MP0003186_abnormal_redox_activity0.98213339
46MP0003195_calcinosis0.98107109
47MP0005647_abnormal_sex_gland0.96087356
48MP0000685_abnormal_immune_system0.95857301
49MP0003191_abnormal_cellular_cholesterol0.93906978
50MP0001502_abnormal_circadian_rhythm0.89839948
51MP0010094_abnormal_chromosome_stability0.88185060
52MP0009840_abnormal_foam_cell0.85843079
53MP0008469_abnormal_protein_level0.83008788
54MP0001835_abnormal_antigen_presentation0.82827620
55MP0005671_abnormal_response_to0.82463833
56MP0002234_abnormal_pharynx_morphology0.76814102
57MP0008995_early_reproductive_senescence0.75832262
58MP0002138_abnormal_hepatobiliary_system0.74468318
59MP0002102_abnormal_ear_morphology0.74419524
60MP0003699_abnormal_female_reproductive0.70414470
61MP0009278_abnormal_bone_marrow0.69186770
62MP0002420_abnormal_adaptive_immunity0.68666763
63MP0002405_respiratory_system_inflammati0.67591640
64MP0001879_abnormal_lymphatic_vessel0.67339273
65MP0005319_abnormal_enzyme/_coenzyme0.66611080
66MP0010771_integument_phenotype0.65149139
67MP0005584_abnormal_enzyme/coenzyme_acti0.64775985
68MP0001853_heart_inflammation0.64580711
69MP0001819_abnormal_immune_cell0.64399101
70MP0005389_reproductive_system_phenotype0.64255862
71MP0002452_abnormal_antigen_presenting0.62514317
72MP0003111_abnormal_nucleus_morphology0.62271629
73MP0001188_hyperpigmentation0.61306738
74MP0009765_abnormal_xenobiotic_induced0.59898815
75MP0010352_gastrointestinal_tract_polyps0.59590997
76MP0003763_abnormal_thymus_physiology0.59388018
77MP0005085_abnormal_gallbladder_physiolo0.59295758
78MP0001119_abnormal_female_reproductive0.58234439
79MP0001881_abnormal_mammary_gland0.56075250
80MP0005636_abnormal_mineral_homeostasis0.55511698
81MP0002429_abnormal_blood_cell0.53563135
82MP0000716_abnormal_immune_system0.52233803
83MP0005423_abnormal_somatic_nervous0.51305980
84MP0001845_abnormal_inflammatory_respons0.50848287
85MP0004142_abnormal_muscle_tone0.49162223
86MP0004808_abnormal_hematopoietic_stem0.48865995
87MP0004742_abnormal_vestibular_system0.48497910
88MP0010307_abnormal_tumor_latency0.48099001
89MP0002132_abnormal_respiratory_system0.48034677
90MP0003448_altered_tumor_morphology0.47925219
91MP0000465_gastrointestinal_hemorrhage0.47898196
92MP0004036_abnormal_muscle_relaxation0.47024927
93MP0001545_abnormal_hematopoietic_system0.46060530
94MP0005397_hematopoietic_system_phenotyp0.46060530
95MP0003633_abnormal_nervous_system0.45994508
96MP0008007_abnormal_cellular_replicative0.44747711
97MP0002419_abnormal_innate_immunity0.44634689
98MP0004782_abnormal_surfactant_physiolog0.44478183
99MP0000490_abnormal_crypts_of0.44331083
100MP0002928_abnormal_bile_duct0.43827210
101MP0003786_premature_aging0.42319932
102MP0001986_abnormal_taste_sensitivity0.42021715
103MP0001293_anophthalmia0.41624506
104MP0002557_abnormal_social/conspecific_i0.41563193
105MP0006072_abnormal_retinal_apoptosis0.40782445
106MP0008873_increased_physiological_sensi0.40776564
107MP0003011_delayed_dark_adaptation0.40613284
108MP0003115_abnormal_respiratory_system0.40362781
109MP0003878_abnormal_ear_physiology0.40011517
110MP0005377_hearing/vestibular/ear_phenot0.40011517
111MP0010155_abnormal_intestine_physiology0.39967308
112MP0003303_peritoneal_inflammation0.39741553
113MP0000427_abnormal_hair_cycle0.39698969
114MP0004145_abnormal_muscle_electrophysio0.39204922
115MP0000470_abnormal_stomach_morphology0.38421524
116MP0003959_abnormal_lean_body0.37844106
117MP0001730_embryonic_growth_arrest0.37782922
118MP0003077_abnormal_cell_cycle0.37286708
119MP0006082_CNS_inflammation0.34471369
120MP0000598_abnormal_liver_morphology0.33460866
121MP0005451_abnormal_body_composition0.32964798
122MP0000609_abnormal_liver_physiology0.32617966
123MP0009115_abnormal_fat_cell0.29162166
124MP0002019_abnormal_tumor_incidence0.28808521
125MP0003045_fibrosis0.28425516
126MP0009333_abnormal_splenocyte_physiolog0.28295827
127MP0003567_abnormal_fetal_cardiomyocyte0.28176291
128MP0003631_nervous_system_phenotype0.28172771
129MP0005666_abnormal_adipose_tissue0.27935013
130MP0005646_abnormal_pituitary_gland0.27851198
131MP0002269_muscular_atrophy0.27504918
132MP0002398_abnormal_bone_marrow0.27287848
133MP0001764_abnormal_homeostasis0.26941461
134MP0002722_abnormal_immune_system0.26594318
135MP0010329_abnormal_lipoprotein_level0.26362926
136MP0002933_joint_inflammation0.25901199
137MP0001324_abnormal_eye_pigmentation0.25136401
138MP0005395_other_phenotype0.25061227
139MP0003656_abnormal_erythrocyte_physiolo0.24915856
140MP0000703_abnormal_thymus_morphology0.24453500
141MP0005551_abnormal_eye_electrophysiolog0.24421888
142MP0000358_abnormal_cell_content/0.23948119
143MP0000313_abnormal_cell_death0.23065570
144MP0002723_abnormal_immune_serum0.22942065
145MP0002693_abnormal_pancreas_physiology0.22907638
146MP0004019_abnormal_vitamin_homeostasis0.22101858
147MP0005253_abnormal_eye_physiology0.22032945
148MP0000534_abnormal_ureter_morphology0.21979223
149MP0002169_no_abnormal_phenotype0.21311036
150MP0003950_abnormal_plasma_membrane0.21267806
151MP0002873_normal_phenotype0.21114989
152MP0003693_abnormal_embryo_hatching0.21096268
153MP0003861_abnormal_nervous_system0.20433310
154MP0003866_abnormal_defecation0.20176967
155MP0001672_abnormal_embryogenesis/_devel0.20107018
156MP0005380_embryogenesis_phenotype0.20107018
157MP0002971_abnormal_brown_adipose0.20088452
158MP0002736_abnormal_nociception_after0.19925578
159MP0002084_abnormal_developmental_patter0.19477687
160MP0004084_abnormal_cardiac_muscle0.19443093
161MP0000432_abnormal_head_morphology0.18774570
162MP0006036_abnormal_mitochondrial_physio0.18506133
163MP0003787_abnormal_imprinting0.18295589
164MP0001727_abnormal_embryo_implantation0.18110923
165MP0003984_embryonic_growth_retardation0.17948817
166MP0004133_heterotaxia0.17893723
167MP0004811_abnormal_neuron_physiology0.17327968
168MP0005391_vision/eye_phenotype0.16794878
169MP0000689_abnormal_spleen_morphology0.16271516
170MP0003436_decreased_susceptibility_to0.16152427

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.55782201
2Abnormal respiratory epithelium morphology (HP:0012253)8.62022901
3Abnormal respiratory motile cilium morphology (HP:0005938)8.62022901
4Fatigue (HP:0012378)8.27341205
5Rhinitis (HP:0012384)8.14297410
6Abnormal ciliary motility (HP:0012262)7.69172200
7Chronic bronchitis (HP:0004469)7.46640449
8Large for gestational age (HP:0001520)7.29544084
9Nasal polyposis (HP:0100582)6.75155800
10Infertility (HP:0000789)6.46474510
11Abnormality of the nasal mucosa (HP:0000433)5.52825438
12Hypoplasia of the ulna (HP:0003022)5.31198495
13Fibular aplasia (HP:0002990)5.08386697
14Progressive muscle weakness (HP:0003323)4.95285072
15Aplasia/Hypoplasia of the ulna (HP:0006495)4.95216168
16Bronchitis (HP:0012387)4.86070097
17Male infertility (HP:0003251)4.82834096
18Increased hepatocellular lipid droplets (HP:0006565)4.82624077
19Colon cancer (HP:0003003)4.76896842
20Bronchiectasis (HP:0002110)4.71493171
21Abnormal pupillary function (HP:0007686)4.67143754
22Absent rod-and cone-mediated responses on ERG (HP:0007688)4.55683692
23Exertional dyspnea (HP:0002875)4.13268960
24Forearm undergrowth (HP:0009821)4.08023378
25Abnormal spermatogenesis (HP:0008669)4.06119929
26Lipid accumulation in hepatocytes (HP:0006561)4.04419990
27Nephronophthisis (HP:0000090)4.03744300
28Aplastic anemia (HP:0001915)3.96409832
29Paralysis (HP:0003470)3.75196160
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.62301154
31Microvesicular hepatic steatosis (HP:0001414)3.60761639
32Ependymoma (HP:0002888)3.59101433
33Recurrent sinusitis (HP:0011108)3.53393015
34Renal Fanconi syndrome (HP:0001994)3.50173062
35Radial bowing (HP:0002986)3.43741727
36Hypercalciuria (HP:0002150)3.41548776
37Recurrent otitis media (HP:0000403)3.39131884
38Deep philtrum (HP:0002002)3.33913739
39Pendular nystagmus (HP:0012043)3.30790849
40Increased intramyocellular lipid droplets (HP:0012240)3.20589253
41Adactyly (HP:0009776)3.12870301
42Recurrent bronchitis (HP:0002837)3.12356529
43Cavernous hemangioma (HP:0001048)3.06145813
44Abnormality of the renal medulla (HP:0100957)3.02156908
45Azoospermia (HP:0000027)2.96079615
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.94176954
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89103568
48Molar tooth sign on MRI (HP:0002419)2.88626528
49Abnormality of midbrain morphology (HP:0002418)2.88626528
50Medial flaring of the eyebrow (HP:0010747)2.87271065
51Cerebral hemorrhage (HP:0001342)2.83396704
52Abnormal rod and cone electroretinograms (HP:0008323)2.81930833
533-Methylglutaconic aciduria (HP:0003535)2.81230815
54Abnormality of the proximal phalanges of the hand (HP:0009834)2.79041711
55Respiratory difficulties (HP:0002880)2.73904315
56Limb hypertonia (HP:0002509)2.73825086
57Short tibia (HP:0005736)2.73333409
58Increased muscle lipid content (HP:0009058)2.72418179
59Increased serum lactate (HP:0002151)2.69784256
60Synostosis involving the elbow (HP:0003938)2.69718396
61Humeroradial synostosis (HP:0003041)2.69718396
62Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.69163121
63Short 1st metacarpal (HP:0010034)2.69163121
64Vertebral fusion (HP:0002948)2.61514757
65Neuroblastoma (HP:0003006)2.60989472
66Primitive neuroectodermal tumor (HP:0030065)2.60989472
67Neuroblastic tumors (HP:0004376)2.60989472
68Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.60989472
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.58905119
70IgG deficiency (HP:0004315)2.53904127
71Generalized amyotrophy (HP:0003700)2.52760745
72Tubular atrophy (HP:0000092)2.51807420
73Impulsivity (HP:0100710)2.42418993
74Spinal cord compression (HP:0002176)2.42042582
75Exercise intolerance (HP:0003546)2.41261146
76Abnormality of the 1st metacarpal (HP:0010009)2.39670948
77Tubulointerstitial nephritis (HP:0001970)2.38248063
78Abnormal albumin level (HP:0012116)2.34836034
79Hypoalbuminemia (HP:0003073)2.34836034
80Astrocytoma (HP:0009592)2.32365866
81Abnormality of the astrocytes (HP:0100707)2.32365866
82Partial agenesis of the corpus callosum (HP:0001338)2.31094671
83Neoplasm of the small intestine (HP:0100833)2.30029030
84Tubulointerstitial abnormality (HP:0001969)2.27780990
85Angiofibromas (HP:0010615)2.26216738
86Adenoma sebaceum (HP:0009720)2.26216738
87Increased CSF lactate (HP:0002490)2.25881562
88Aplasia/hypoplasia of the uterus (HP:0008684)2.24138999
89Hypoplasia of the radius (HP:0002984)2.23809424
90Urticaria (HP:0001025)2.22438836
91Hyperphosphaturia (HP:0003109)2.21338135
92Enlarged epiphyses (HP:0010580)2.20832200
93Bony spicule pigmentary retinopathy (HP:0007737)2.20718585
94Neoplasm of the peripheral nervous system (HP:0100007)2.20476419
95Progressive microcephaly (HP:0000253)2.18646350
96Pheochromocytoma (HP:0002666)2.17832028
97Aplasia/Hypoplasia of the fibula (HP:0006492)2.16578796
98Abnormality of the middle phalanges of the toes (HP:0010183)2.16569772
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.13612539
100Bowed forearm bones (HP:0003956)2.12838662
101Bowing of the arm (HP:0006488)2.12838662
102Nephrocalcinosis (HP:0000121)2.12493560
103Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.04883019
104Pancreatic fibrosis (HP:0100732)2.02323207
105Delayed CNS myelination (HP:0002188)2.02237486
106Hamartoma of the eye (HP:0010568)2.01993001
107Tubulointerstitial fibrosis (HP:0005576)2.01620243
108Stomatitis (HP:0010280)2.01524094
109Posterior subcapsular cataract (HP:0007787)2.01169604
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.9177596
111Absent/shortened dynein arms (HP:0200106)12.4007998
112Dynein arm defect of respiratory motile cilia (HP:0012255)12.4007998
113Symphalangism affecting the phalanges of the hand (HP:0009773)1.99844410
114Conjunctival hamartoma (HP:0100780)1.99230434
115Aplasia/hypoplasia of the humerus (HP:0006507)1.96436670
116Postaxial foot polydactyly (HP:0001830)1.96361624
117Portal hypertension (HP:0001409)1.95290265
118Tongue fasciculations (HP:0001308)1.94987295
119Abnormality of the phalanges of the 5th finger (HP:0004213)1.94262374
120Lactic acidosis (HP:0003128)1.92197210
121Nervous tissue neoplasm (HP:0030060)1.91801712
122Neuroectodermal neoplasm (HP:0030061)1.91801712
123Neuroepithelial neoplasm (HP:0030063)1.91801712
124Abnormality of renal resorption (HP:0011038)1.91219131
125Facial cleft (HP:0002006)1.91176302
126Congenital hepatic fibrosis (HP:0002612)1.90169980
127Oral leukoplakia (HP:0002745)1.89312287
128Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.88277353
129Respiratory insufficiency due to muscle weakness (HP:0002747)1.87997634
130Mitochondrial inheritance (HP:0001427)1.87846530
131Cerebellar hypoplasia (HP:0001321)1.87792093
132Abnormality of the hepatic vasculature (HP:0006707)1.86641047
133Gonadotropin excess (HP:0000837)1.85948356
134Microglossia (HP:0000171)1.82865778
135Abnormal drinking behavior (HP:0030082)1.81508978
136Polydipsia (HP:0001959)1.81508978
137Chronic sinusitis (HP:0011109)1.79280959
138Muscle fibrillation (HP:0010546)1.78045586
139Decreased central vision (HP:0007663)1.77866309
140Congenital primary aphakia (HP:0007707)1.76434206
141Gait imbalance (HP:0002141)1.75668810
142Dyschromatopsia (HP:0007641)1.71555645
143Bile duct proliferation (HP:0001408)1.67953133
144Abnormal biliary tract physiology (HP:0012439)1.67953133
145Abnormality of saccadic eye movements (HP:0000570)1.63994008
146Postaxial hand polydactyly (HP:0001162)1.61601276
147Stage 5 chronic kidney disease (HP:0003774)1.61415973
148Median cleft lip (HP:0000161)1.60627970
149Abnormality of the renal cortex (HP:0011035)1.58859420
150Short ribs (HP:0000773)1.58541175
151Cholecystitis (HP:0001082)1.57781337
152Abnormal gallbladder physiology (HP:0012438)1.57781337
153Abnormality of renal excretion (HP:0011036)1.57572676
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.56662841
155Aplasia/Hypoplasia of the lens (HP:0008063)1.55156727
156Spastic tetraparesis (HP:0001285)1.54677828
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54176467
158Fibular hypoplasia (HP:0003038)1.51745543
159Renal dysplasia (HP:0000110)1.50734973
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.50328260
161Heterotopia (HP:0002282)1.49890774
162Cystic liver disease (HP:0006706)1.49878060
163Nephrogenic diabetes insipidus (HP:0009806)1.47665016
164Absent frontal sinuses (HP:0002688)1.46747561
165Oculomotor apraxia (HP:0000657)1.44988012
166Genital tract atresia (HP:0001827)1.44701828
167Abnormality of ocular smooth pursuit (HP:0000617)1.43507642
168Increased IgM level (HP:0003496)1.41197492
169Spontaneous abortion (HP:0005268)1.37712740
170Impaired smooth pursuit (HP:0007772)1.37139531
171Taurodontia (HP:0000679)1.35321290
172Abnormality of permanent molar morphology (HP:0011071)1.35321290
173Abnormality of the dental root (HP:0006486)1.35321290
174Vaginal atresia (HP:0000148)1.34259942
175Optic nerve hypoplasia (HP:0000609)1.33493363
176Poor coordination (HP:0002370)1.32109159
177Double outlet right ventricle (HP:0001719)1.30968428
178Congenital malformation of the right heart (HP:0011723)1.30968428
179Easy fatigability (HP:0003388)1.27870020
180Abnormal urine output (HP:0012590)1.27838376
181True hermaphroditism (HP:0010459)1.27595662
182Abnormality of the dental pulp (HP:0006479)1.27509908
183Impaired proprioception (HP:0010831)1.27267341
184Bundle branch block (HP:0011710)1.27017461
185Choroideremia (HP:0001139)1.26814653
186Pancreatic cysts (HP:0001737)1.26114479
187Abnormality of molar morphology (HP:0011070)1.26093240
188Abnormality of molar (HP:0011077)1.26093240
189Deformed sella turcica (HP:0002681)1.25046161
190Absent eyebrow (HP:0002223)1.24377596
191Abnormality of the lower motor neuron (HP:0002366)1.23346203
192Hemorrhage of the eye (HP:0011885)1.22203296
193J-shaped sella turcica (HP:0002680)1.21009150
194Absent epiphyses (HP:0010577)1.20004074
195Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.20004074
196Asymmetric septal hypertrophy (HP:0001670)1.19595883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.36685491
2PDK48.36685491
3BRD45.97205721
4TESK15.46860117
5PDK25.33419449
6PRKD34.30340177
7ICK3.75250368
8NME13.69728113
9EIF2AK13.27309316
10TNIK3.18141971
11PIK3CG2.82703702
12TSSK62.57329728
13SRPK12.49398329
14PTK2B2.46335656
15STK392.38612324
16WNK42.38594373
17STK42.32616384
18PBK12.6515020
19STK381.83171120
20NEK21.79507340
21STK241.37988028
22PDK11.36500455
23MST41.32620937
24ADRBK21.26046278
25PNCK1.22843833
26VRK21.21245876
27DYRK1B1.20059664
28TYRO31.10889104
29EIF2AK31.08416499
30NLK1.05136072
31MKNK21.02879161
32BRSK21.00771253
33DYRK30.99462200
34TNK20.99406940
35ZAP700.97659516
36AKT30.90885009
37WEE10.86408190
38STK38L0.85738549
39CCNB10.85501138
40TXK0.84890524
41CHEK20.84041575
42TTK0.82108574
43PDPK10.79443173
44WNK10.79437673
45EEF2K0.77563247
46STK30.77030367
47MAP4K10.74672328
48RIPK40.73769618
49TLK10.73752106
50LMTK20.70698083
51PAK60.68950830
52IRAK10.68648982
53CSK0.68134692
54PLK40.65663478
55TEC0.63251129
56MKNK10.61658764
57PASK0.60157049
58TESK20.59739543
59IKBKB0.59594608
60CDK80.58315305
61CHEK10.57354239
62MAP3K120.55355967
63TAOK30.54090731
64CDC70.52615415
65MAPK150.50053450
66BCKDK0.49965429
67PAK40.49159169
68NTRK20.48504264
69LCK0.46790942
70TAOK10.46107254
71NME20.45658478
72BRSK10.45489959
73MET0.43099455
74MUSK0.42610196
75RPS6KA40.38645973
76ATR0.37780002
77MAP2K60.35798658
78PLK10.35683234
79ATM0.35268599
80IRAK40.35153284
81MST1R0.34948705
82BMPR1B0.34566756
83GRK10.34181193
84MYLK0.33794929
85GSK3A0.33604145
86PINK10.33350162
87MAP2K70.33263578
88FGR0.32857585
89PAK10.32840460
90ADRBK10.30956527
91CDK120.30377703
92MAP2K20.29710516
93STK100.29040131
94PRKCG0.28239748
95IRAK20.27100721
96PRKCQ0.26832964
97MAP3K110.25933165
98BMX0.25081290
99MARK30.23787921
100EIF2AK20.23783644
101PDGFRB0.22987838
102GRK70.22943686
103CAMK1D0.22902124
104NEK60.22037964
105PAK30.21680783
106FES0.21622279
107PAK20.20284939
108MELK0.19998234
109MAP3K100.18618104
110CSF1R0.18023103
111RPS6KA10.17803115
112MAP3K50.17234609
113PRKAA10.16424159
114CDK30.16178915
115CAMK1G0.14150984
116MAPKAPK50.13732146
117PIM10.13333070
118MARK20.12340429
119CDK90.11932563
120CSNK2A10.11731662
121FGFR10.11498355
122CDK150.11479645
123MTOR0.11265989
124RPS6KB10.11247617
125BTK0.10837519
126CAMK2G0.10837036
127PRKCZ0.10666629
128PRKG20.09740477
129CDK10.09462785
130MAP3K40.09451208
131CAMKK10.09323444
132VRK10.08948632
133CSNK2A20.08607410
134ALK0.08452539
135CDK180.08014458
136AURKB0.07916834
137CDK20.07903091
138MAP3K140.07842600
139CAMK2D0.07729543
140AURKA0.07691555
141CDK11A0.07638652
142TRIM280.07524524
143STK110.07097627
144JAK30.07076043
145ITK0.07046458
146MAP3K60.06639097
147ACVR1B0.06385817
148CDK40.06335478
149GSK3B0.06203325
150INSR0.05828663
151MAPK80.05811573
152EGFR0.05409279
153IGF1R0.05278272
154CASK0.04343887
155SIK30.04258809
156PRKG10.03186020
157PKN10.03128619
158BMPR20.02991807
159RPS6KA50.02954202
160TBK10.02950175
161MAP3K30.02339322
162DAPK20.02299140
163BRAF0.01720393
164PRKACG0.01553338
165CHUK0.01189154
166PRKCB0.01161991
167LYN0.01124075
168MAP3K10.00969216
169TGFBR10.00679608
170RET0.00581993
171IRAK30.00130227
172ABL1-2.7566553

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.07812083
2Fatty acid biosynthesis_Homo sapiens_hsa000613.85720589
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.75848760
4Fc epsilon RI signaling pathway_Homo sapiens_hsa046643.48605311
5Allograft rejection_Homo sapiens_hsa053303.33999447
6Basal transcription factors_Homo sapiens_hsa030223.10101127
7Pyruvate metabolism_Homo sapiens_hsa006202.97093766
8Pentose phosphate pathway_Homo sapiens_hsa000302.77349123
9Asthma_Homo sapiens_hsa053102.68549984
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67127102
11Linoleic acid metabolism_Homo sapiens_hsa005912.66274300
12Hematopoietic cell lineage_Homo sapiens_hsa046402.55279324
13Propanoate metabolism_Homo sapiens_hsa006402.36022146
14Autoimmune thyroid disease_Homo sapiens_hsa053202.34346987
15Glucagon signaling pathway_Homo sapiens_hsa049222.33844610
16RNA polymerase_Homo sapiens_hsa030202.06373504
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98476900
18Protein export_Homo sapiens_hsa030601.90472354
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.85213622
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83476117
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.78627814
22Fanconi anemia pathway_Homo sapiens_hsa034601.76673930
23Oocyte meiosis_Homo sapiens_hsa041141.75760572
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.74112487
25Glycerolipid metabolism_Homo sapiens_hsa005611.68577462
26Graft-versus-host disease_Homo sapiens_hsa053321.65115668
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.57276311
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53295932
29Selenocompound metabolism_Homo sapiens_hsa004501.52219741
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.51003421
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.50122677
32Type I diabetes mellitus_Homo sapiens_hsa049401.43916571
33PPAR signaling pathway_Homo sapiens_hsa033201.34412275
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30562593
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25721039
36RNA transport_Homo sapiens_hsa030131.23334985
37Mineral absorption_Homo sapiens_hsa049781.21896167
38Ether lipid metabolism_Homo sapiens_hsa005651.19524294
39Carbon metabolism_Homo sapiens_hsa012001.17370330
40Amphetamine addiction_Homo sapiens_hsa050311.17205722
41T cell receptor signaling pathway_Homo sapiens_hsa046601.16065882
42Dorso-ventral axis formation_Homo sapiens_hsa043201.15233617
43Antigen processing and presentation_Homo sapiens_hsa046121.13348132
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11869389
45mRNA surveillance pathway_Homo sapiens_hsa030151.09867779
46Proteasome_Homo sapiens_hsa030501.09745719
47Renin-angiotensin system_Homo sapiens_hsa046141.08733424
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.05917581
49Biosynthesis of amino acids_Homo sapiens_hsa012301.04887504
50Purine metabolism_Homo sapiens_hsa002301.04316372
51Fat digestion and absorption_Homo sapiens_hsa049751.03972915
52Leishmaniasis_Homo sapiens_hsa051401.03289945
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00365865
54Fructose and mannose metabolism_Homo sapiens_hsa000510.97987146
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87300986
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85365347
57Renin secretion_Homo sapiens_hsa049240.84829004
58Cardiac muscle contraction_Homo sapiens_hsa042600.79161830
59Huntingtons disease_Homo sapiens_hsa050160.77356601
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.77311624
61Ribosome_Homo sapiens_hsa030100.76272947
62Fatty acid metabolism_Homo sapiens_hsa012120.73376094
63Fatty acid degradation_Homo sapiens_hsa000710.72531424
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71737967
65Systemic lupus erythematosus_Homo sapiens_hsa053220.71172959
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70521693
67Primary immunodeficiency_Homo sapiens_hsa053400.69337358
68Caffeine metabolism_Homo sapiens_hsa002320.65170416
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.63919659
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63584222
71Glutathione metabolism_Homo sapiens_hsa004800.61266240
72Mismatch repair_Homo sapiens_hsa034300.58904581
73Measles_Homo sapiens_hsa051620.58834082
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57984781
75Steroid biosynthesis_Homo sapiens_hsa001000.57847361
76Cell cycle_Homo sapiens_hsa041100.56076409
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53975501
78Legionellosis_Homo sapiens_hsa051340.52939818
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52924522
80Arachidonic acid metabolism_Homo sapiens_hsa005900.51278528
81Spliceosome_Homo sapiens_hsa030400.51246256
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.48532606
83Chemokine signaling pathway_Homo sapiens_hsa040620.47193267
84Insulin secretion_Homo sapiens_hsa049110.46509106
85Long-term potentiation_Homo sapiens_hsa047200.46357312
86Chemical carcinogenesis_Homo sapiens_hsa052040.46048261
87Estrogen signaling pathway_Homo sapiens_hsa049150.42830934
88Oxidative phosphorylation_Homo sapiens_hsa001900.42468749
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41432033
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.41051698
91Collecting duct acid secretion_Homo sapiens_hsa049660.40988141
92Thyroid hormone synthesis_Homo sapiens_hsa049180.39493885
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39365521
94Toxoplasmosis_Homo sapiens_hsa051450.39182973
95Herpes simplex infection_Homo sapiens_hsa051680.37628263
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37519527
97RNA degradation_Homo sapiens_hsa030180.36102481
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35544423
99Inositol phosphate metabolism_Homo sapiens_hsa005620.34630196
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34024571
101Homologous recombination_Homo sapiens_hsa034400.33780675
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33700668
103Endocytosis_Homo sapiens_hsa041440.33600111
104Arginine and proline metabolism_Homo sapiens_hsa003300.33170670
105Pyrimidine metabolism_Homo sapiens_hsa002400.33089020
106Hedgehog signaling pathway_Homo sapiens_hsa043400.32688153
107Viral carcinogenesis_Homo sapiens_hsa052030.32047791
108Malaria_Homo sapiens_hsa051440.31411869
109Bile secretion_Homo sapiens_hsa049760.31354466
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.31098940
111Nitrogen metabolism_Homo sapiens_hsa009100.30058784
112Calcium signaling pathway_Homo sapiens_hsa040200.27941516
113Pancreatic secretion_Homo sapiens_hsa049720.27720377
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27009132
115Rheumatoid arthritis_Homo sapiens_hsa053230.27006222
116ABC transporters_Homo sapiens_hsa020100.26911185
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25463483
118Salmonella infection_Homo sapiens_hsa051320.25386282
119VEGF signaling pathway_Homo sapiens_hsa043700.24387988
120Circadian rhythm_Homo sapiens_hsa047100.24306538
121TNF signaling pathway_Homo sapiens_hsa046680.24132100
122AMPK signaling pathway_Homo sapiens_hsa041520.23689222
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22055339
124Ovarian steroidogenesis_Homo sapiens_hsa049130.21623059
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.20010517
126HTLV-I infection_Homo sapiens_hsa051660.19913248
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19809141
128Metabolic pathways_Homo sapiens_hsa011000.19653490
129Nucleotide excision repair_Homo sapiens_hsa034200.19261955
130Phototransduction_Homo sapiens_hsa047440.18912062
131Peroxisome_Homo sapiens_hsa041460.18148425
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18072438
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15465521
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11735339
135Parkinsons disease_Homo sapiens_hsa050120.11698252
136TGF-beta signaling pathway_Homo sapiens_hsa043500.08782514
137Apoptosis_Homo sapiens_hsa042100.05719599
138Epstein-Barr virus infection_Homo sapiens_hsa051690.04631310
139One carbon pool by folate_Homo sapiens_hsa006700.03415519
140Olfactory transduction_Homo sapiens_hsa047400.01230129
141Small cell lung cancer_Homo sapiens_hsa052220.00017967
142Pancreatic cancer_Homo sapiens_hsa05212-0.0901965
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0865500
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0720267
145Prolactin signaling pathway_Homo sapiens_hsa04917-0.0719306
146Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0717735
147Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0705565
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650-0.0574491
149Alzheimers disease_Homo sapiens_hsa05010-0.0566590
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0542926
151Non-homologous end-joining_Homo sapiens_hsa03450-0.0494231
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400-0.0429088
153Salivary secretion_Homo sapiens_hsa04970-0.0205398
154Type II diabetes mellitus_Homo sapiens_hsa04930-0.0183103
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0171860
156Retinol metabolism_Homo sapiens_hsa00830-0.0078700
157Viral myocarditis_Homo sapiens_hsa05416-0.0071792

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »