IL31RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.53609882
2desmosome organization (GO:0002934)6.75323220
3ribosomal small subunit biogenesis (GO:0042274)5.76369595
4viral transcription (GO:0019083)5.60425598
5cell adhesion mediated by integrin (GO:0033627)5.36299959
6translational termination (GO:0006415)5.34597043
7regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.24606089
8regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.24606089
9membrane raft organization (GO:0031579)5.23999508
10establishment of skin barrier (GO:0061436)5.21141447
11adenosine metabolic process (GO:0046085)5.05760179
12negative regulation of keratinocyte proliferation (GO:0010839)4.94525548
13outer ear morphogenesis (GO:0042473)4.75067377
14keratinocyte proliferation (GO:0043616)4.69359669
15maturation of SSU-rRNA (GO:0030490)4.66874287
16skin morphogenesis (GO:0043589)4.43936812
17response to peptidoglycan (GO:0032494)4.41812552
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41764612
19positive regulation of megakaryocyte differentiation (GO:0045654)4.33352165
20cotranslational protein targeting to membrane (GO:0006613)4.31855424
21regulation of water loss via skin (GO:0033561)4.30240309
22protein targeting to ER (GO:0045047)4.27603902
23translational elongation (GO:0006414)4.26837097
24sympathetic nervous system development (GO:0048485)4.18526124
25cellular response to vitamin D (GO:0071305)4.16908747
26regulation of glucocorticoid metabolic process (GO:0031943)4.12637011
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09405072
28cellular protein complex disassembly (GO:0043624)4.07295024
29protein hydroxylation (GO:0018126)4.06578478
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.06464041
31gland morphogenesis (GO:0022612)4.04893639
32mesodermal cell differentiation (GO:0048333)4.03196502
33positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.02576794
34protein localization to endoplasmic reticulum (GO:0070972)4.00603318
35cranial nerve morphogenesis (GO:0021602)3.99776614
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.98172270
37prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.96910727
38viral life cycle (GO:0019058)3.86440656
39regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.83351188
40regulation of metalloenzyme activity (GO:0048552)3.81303732
41epidermis development (GO:0008544)3.80095611
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79604852
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.71238018
44mitotic chromosome condensation (GO:0007076)3.68858674
45angiogenesis involved in wound healing (GO:0060055)3.66555662
46multicellular organismal water homeostasis (GO:0050891)3.59063973
47protein localization to endosome (GO:0036010)3.56293375
48limb bud formation (GO:0060174)3.54878924
49AMP metabolic process (GO:0046033)3.51500643
50negative regulation of osteoblast proliferation (GO:0033689)3.51011591
51negative regulation of leukocyte chemotaxis (GO:0002689)3.50336119
52cell-substrate junction assembly (GO:0007044)3.49305734
53positive regulation of actin filament depolymerization (GO:0030836)3.47203291
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46951147
55hair follicle morphogenesis (GO:0031069)3.46394460
56protein maturation by protein folding (GO:0022417)3.44867804
57positive regulation of keratinocyte differentiation (GO:0045618)3.43562745
58wound healing, spreading of epidermal cells (GO:0035313)3.42967308
59heart valve formation (GO:0003188)3.42114513
60cell wall macromolecule catabolic process (GO:0016998)3.39614698
61protein complex disassembly (GO:0043241)3.38672654
62membrane protein ectodomain proteolysis (GO:0006509)3.37163358
63water homeostasis (GO:0030104)3.34459772
64cellular copper ion homeostasis (GO:0006878)3.26533689
65type B pancreatic cell proliferation (GO:0044342)3.26208931
66negative regulation of bone remodeling (GO:0046851)3.24765315
67negative regulation of anoikis (GO:2000811)3.24636866
68regulation of keratinocyte proliferation (GO:0010837)3.20941077
69regulation of female gonad development (GO:2000194)3.20888546
70regulation of interleukin-8 secretion (GO:2000482)3.18630619
71substrate-dependent cell migration (GO:0006929)3.18334334
72translational initiation (GO:0006413)3.17230125
73membrane budding (GO:0006900)3.16591020
74pore complex assembly (GO:0046931)3.13987533
75regulation of neurotransmitter uptake (GO:0051580)3.13053614
76macromolecular complex disassembly (GO:0032984)3.12444830
77keratinization (GO:0031424)3.12039128
78detection of bacterium (GO:0016045)3.11034776
79myoblast migration (GO:0051451)3.10916109
80Golgi transport vesicle coating (GO:0048200)3.09614150
81COPI coating of Golgi vesicle (GO:0048205)3.09614150
82regulation of hair follicle development (GO:0051797)3.08928251
83ribosomal large subunit biogenesis (GO:0042273)3.08386516
84regulation of keratinocyte differentiation (GO:0045616)3.05916943
85positive regulation of hair follicle development (GO:0051798)3.04748936
86positive regulation of hair cycle (GO:0042635)3.04748936
87negative regulation of interleukin-8 production (GO:0032717)3.04207979
88hepatocyte differentiation (GO:0070365)3.03205974
89neutrophil mediated immunity (GO:0002446)3.03187962
90regulation of hair cycle (GO:0042634)3.02326534
91positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01675009
92positive regulation of catecholamine secretion (GO:0033605)3.00118014
93iron ion import (GO:0097286)2.99767830
94negative regulation of osteoclast differentiation (GO:0045671)2.99230200
95detection of other organism (GO:0098543)2.99152239
96maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98756481
97response to xenobiotic stimulus (GO:0009410)2.95285287
98protein targeting to membrane (GO:0006612)2.95005825
99protein heterotetramerization (GO:0051290)2.94811784
100hyaluronan catabolic process (GO:0030214)2.94699140
101response to gravity (GO:0009629)2.94678134
102fusion of sperm to egg plasma membrane (GO:0007342)2.93255760
103natural killer cell mediated immunity (GO:0002228)2.92995214
104natural killer cell mediated cytotoxicity (GO:0042267)2.92995214
105membrane protein intracellular domain proteolysis (GO:0031293)2.92037965
106nuclear pore complex assembly (GO:0051292)2.90933650
107hypotonic response (GO:0006971)2.90732278
108mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.90253954
109otic vesicle formation (GO:0030916)2.89483647
110pyrimidine nucleoside salvage (GO:0043097)2.89114322
111pyrimidine-containing compound salvage (GO:0008655)2.89114322
112actin filament depolymerization (GO:0030042)2.87975095
113negative regulation of bone mineralization (GO:0030502)2.87583322
114cellular response to vitamin (GO:0071295)2.86321389
115wound healing, spreading of cells (GO:0044319)2.86297176
116embryonic viscerocranium morphogenesis (GO:0048703)2.85365252
117interleukin-1-mediated signaling pathway (GO:0070498)2.84811258
118mitotic sister chromatid cohesion (GO:0007064)2.84677270
119negative regulation of chemokine production (GO:0032682)2.83808560
120positive regulation of odontogenesis (GO:0042482)2.82464381
121peptidyl-proline hydroxylation (GO:0019511)2.81770862
122regulation of proton transport (GO:0010155)2.81343448
123lymph vessel development (GO:0001945)2.81150152
124negative regulation of hormone biosynthetic process (GO:0032353)2.81027281
125negative regulation of hormone metabolic process (GO:0032351)2.81027281
126thyroid gland development (GO:0030878)2.79201646
127pinocytosis (GO:0006907)2.79034898
128kynurenine metabolic process (GO:0070189)2.77824428
129positive regulation of urine volume (GO:0035810)2.77482309
130positive regulation of granulocyte differentiation (GO:0030854)2.77298401
131SMAD protein complex assembly (GO:0007183)2.76661010
132peptide cross-linking (GO:0018149)2.75169649
133negative regulation of fibroblast apoptotic process (GO:2000270)2.74780907
134cell wall macromolecule metabolic process (GO:0044036)2.73548523
135regulation of B cell differentiation (GO:0045577)2.73010514
136negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72618850
137positive regulation of epidermis development (GO:0045684)2.71885810
138cellular response to exogenous dsRNA (GO:0071360)2.71710568
139ribosome assembly (GO:0042255)2.71600689
140negative regulation of phagocytosis (GO:0050765)2.68528362
141negative regulation of interleukin-17 production (GO:0032700)2.68360607
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66315392
143positive regulation of interleukin-8 secretion (GO:2000484)2.65509718
144reactive oxygen species biosynthetic process (GO:1903409)2.65478872
145lateral sprouting from an epithelium (GO:0060601)2.65086300
146keratinocyte differentiation (GO:0030216)2.64581111
147positive regulation of type 2 immune response (GO:0002830)2.64523381
148nuclear-transcribed mRNA catabolic process (GO:0000956)2.64064868
149response to UV-B (GO:0010224)2.61811026
150negative regulation of biomineral tissue development (GO:0070168)2.61675664
151peripheral nervous system neuron development (GO:0048935)2.60094303
152protein retention in ER lumen (GO:0006621)2.59613138
153cellular response to arsenic-containing substance (GO:0071243)2.59514934
154regulation of interleukin-8 biosynthetic process (GO:0045414)2.57310823
155barbed-end actin filament capping (GO:0051016)2.57005590
156regulation of dopamine secretion (GO:0014059)2.56921649
157lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56524054
158chondrocyte proliferation (GO:0035988)2.55399217
159retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51460163
160membrane protein proteolysis (GO:0033619)2.51219332
161DNA packaging (GO:0006323)2.49699611
162lipopolysaccharide metabolic process (GO:0008653)2.49420613
163ER overload response (GO:0006983)2.46976055
164positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.46557247
165stress fiber assembly (GO:0043149)2.44773519
166regulation of interleukin-12 biosynthetic process (GO:0045075)2.41739567
167regulation of anoikis (GO:2000209)2.41550930
168heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.41381597
169histone-serine phosphorylation (GO:0035404)2.40799936
170regulation of chronic inflammatory response (GO:0002676)2.40715592
171chromosome condensation (GO:0030261)2.40637065
172COPII vesicle coating (GO:0048208)2.40477609
173myeloid leukocyte mediated immunity (GO:0002444)2.39563447
174copper ion homeostasis (GO:0055070)2.38898521
175neutrophil activation involved in immune response (GO:0002283)2.37640024
176glomerular visceral epithelial cell development (GO:0072015)2.37518883
177regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.36551197
178detection of molecule of bacterial origin (GO:0032490)2.36338503
179muscle cell migration (GO:0014812)2.35219372
180leukocyte mediated cytotoxicity (GO:0001909)2.35021633
181positive regulation of interleukin-12 production (GO:0032735)2.34010313
182negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.34007041
183regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31280607
184cellular response to zinc ion (GO:0071294)2.29627545
185regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29424863
186negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.28449748
187cortical actin cytoskeleton organization (GO:0030866)2.28115614
188indole-containing compound catabolic process (GO:0042436)2.27818584
189indolalkylamine catabolic process (GO:0046218)2.27818584
190tryptophan catabolic process (GO:0006569)2.27818584
191oligosaccharide catabolic process (GO:0009313)2.27122123
192regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.26436368
193negative regulation of JAK-STAT cascade (GO:0046426)2.24213234
194hemidesmosome assembly (GO:0031581)12.6025574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.76961756
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.77614516
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse5.47204651
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.96320839
5E2F7_22180533_ChIP-Seq_HELA_Human4.47857328
6RBPJ_22232070_ChIP-Seq_NCS_Mouse4.45901123
7IGF1R_20145208_ChIP-Seq_DFB_Human3.55487393
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18877827
9* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.01657656
10* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.92345067
11* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.88291947
12AR_21572438_ChIP-Seq_LNCaP_Human2.82770220
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.66664644
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57735542
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54710796
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.51027172
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.42133384
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40971071
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36156461
20AR_21909140_ChIP-Seq_LNCAP_Human2.30090567
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.29094982
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.22742118
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20282142
24P63_26484246_Chip-Seq_KERATINOCYTES_Human2.17532381
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17268663
26* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11337122
27SCL_19346495_ChIP-Seq_HPC-7_Human2.08392430
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08096984
29* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07162881
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.06965661
31* ATF3_27146783_Chip-Seq_COLON_Human2.03242711
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.99265998
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97292979
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96361302
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.92293726
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92231909
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92231909
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82529020
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82401918
40TFEB_21752829_ChIP-Seq_HELA_Human1.79124366
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78690507
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76724918
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73088771
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71695923
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.64439398
46TAF15_26573619_Chip-Seq_HEK293_Human1.64239008
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.63631094
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.62723273
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60860137
50VDR_24787735_ChIP-Seq_THP-1_Human1.59247841
51* CJUN_26792858_Chip-Seq_BT549_Human1.58433519
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55504532
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55071286
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54026575
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53567447
56ELK1_19687146_ChIP-ChIP_HELA_Human1.51288830
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50888512
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49483743
59VDR_24763502_ChIP-Seq_THP-1_Human1.49013971
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48381277
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.47331431
62MYC_18940864_ChIP-ChIP_HL60_Human1.40815369
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40630069
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.40197795
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39011766
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35192064
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32963004
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29881178
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28120694
70* TP63_23658742_ChIP-Seq_EP156T_Human1.19995719
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19758863
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19448873
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19448873
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19448873
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.19329408
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18535735
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18398967
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17721092
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17407019
80BCAT_22108803_ChIP-Seq_LS180_Human1.16163096
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15512835
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14224654
83EGR1_19032775_ChIP-ChIP_M12_Human1.12490772
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10206932
85CSB_26484114_Chip-Seq_FIBROBLAST_Human1.09498837
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08545958
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08110704
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.05481906
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03106219
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02270550
91* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02101981
92TP53_16413492_ChIP-PET_HCT116_Human1.01650059
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00592059
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00592059
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97699774
96TP53_22127205_ChIP-Seq_IMR90_Human0.96522422
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.95949002
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95415454
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94232050
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94028498
101HTT_18923047_ChIP-ChIP_STHdh_Human0.93733270
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93597670
103SPI1_23547873_ChIP-Seq_NB4_Human0.93202134
104SPI1_23127762_ChIP-Seq_K562_Human0.92747810
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.92670817
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91751219
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.90102937
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88915760
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88807974
110CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88350324
111CLOCK_20551151_ChIP-Seq_293T_Human0.87565509
112EWS_26573619_Chip-Seq_HEK293_Human0.87488058
113ZNF263_19887448_ChIP-Seq_K562_Human0.87384161
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86843606
115RNF2_27304074_Chip-Seq_ESCs_Mouse0.84894293
116ELF5_23300383_ChIP-Seq_T47D_Human0.84433096
117VDR_21846776_ChIP-Seq_THP-1_Human0.84391798
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.83954369
119CDX2_22108803_ChIP-Seq_LS180_Human0.83844708
120* TP63_22573176_ChIP-Seq_HFKS_Human0.83098327
121TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82968983
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.82023091
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81977376
124* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81291680
125GATA1_22025678_ChIP-Seq_K562_Human0.80743960
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80360839
127GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80235142
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.80205517
129AHR_22903824_ChIP-Seq_MCF-7_Human0.79994643
130* GATA3_21867929_ChIP-Seq_TH1_Mouse0.78800749
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78028316
132PHF8_20622853_ChIP-Seq_HELA_Human0.77994875
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77669292
134CBP_21632823_ChIP-Seq_H3396_Human0.77187682
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76799538
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76369478
137SALL4_22934838_ChIP-ChIP_CD34+_Human0.75905219
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75463571
139RUNX_20019798_ChIP-Seq_JUKART_Human0.74746376
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74434789
141ETV1_20927104_ChIP-Seq_GIST48_Human0.74364834
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.73645531
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73505878
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73201224
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72418460
146TBL1_22424771_ChIP-Seq_293T_Human0.71949785
147TP53_18474530_ChIP-ChIP_U2OS_Human0.71339384
148RBPJ_21746931_ChIP-Seq_IB4_Human0.70299807
149SOX2_20726797_ChIP-Seq_SW620_Human0.69155557
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.69074170
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.68988299
152HNFA_21074721_ChIP-Seq_CACO-2_Human0.68702194
153GATA6_21074721_ChIP-Seq_CACO-2_Human0.68174569
154STAT1_17558387_ChIP-Seq_HELA_Human0.68092332
155TCF4_22108803_ChIP-Seq_LS180_Human0.66986537
156IRF8_21731497_ChIP-ChIP_J774_Mouse0.66905908
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66752149
158SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.66094815
159UBF1/2_26484160_Chip-Seq_HMECs_Human0.65754091
160SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65533351
161BRD4_25478319_ChIP-Seq_HGPS_Human0.65196891
162TDRD3_21172665_ChIP-Seq_MCF-7_Human0.64389469
163FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.63063229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.83826557
2MP0003950_abnormal_plasma_membrane4.68893061
3MP0002877_abnormal_melanocyte_morpholog4.05503248
4MP0002060_abnormal_skin_morphology3.89823626
5MP0010234_abnormal_vibrissa_follicle3.70384714
6MP0002009_preneoplasia3.68296462
7MP0002254_reproductive_system_inflammat3.39338234
8MP0004381_abnormal_hair_follicle3.34521689
9MP0000427_abnormal_hair_cycle3.31181737
10MP0002796_impaired_skin_barrier3.19539128
11MP0000579_abnormal_nail_morphology3.07608696
12MP0001346_abnormal_lacrimal_gland2.99456438
13MP0000762_abnormal_tongue_morphology2.85365107
14MP0002332_abnormal_exercise_endurance2.83151609
15MP0003191_abnormal_cellular_cholesterol2.76319267
16MP0001851_eye_inflammation2.73560110
17MP0001216_abnormal_epidermal_layer2.65819123
18MP0005623_abnormal_meninges_morphology2.59184494
19MP0003941_abnormal_skin_development2.46862338
20MP0002249_abnormal_larynx_morphology2.40555026
21MP0004510_myositis2.39697283
22MP0002098_abnormal_vibrissa_morphology2.38087009
23MP0000383_abnormal_hair_follicle2.37048918
24MP0009697_abnormal_copulation2.34633042
25MP0002132_abnormal_respiratory_system2.34006456
26MP0002396_abnormal_hematopoietic_system2.26225548
27MP0000678_abnormal_parathyroid_gland2.25722123
28MP0000749_muscle_degeneration2.24302385
29MP0010771_integument_phenotype2.24182384
30MP0003091_abnormal_cell_migration2.20169609
31MP0003806_abnormal_nucleotide_metabolis2.16654335
32MP0001919_abnormal_reproductive_system2.09710437
33MP0000467_abnormal_esophagus_morphology2.05310848
34MP0005257_abnormal_intraocular_pressure2.00179385
35MP0000750_abnormal_muscle_regeneration1.99774821
36MP0000465_gastrointestinal_hemorrhage1.97786824
37MP0005501_abnormal_skin_physiology1.97056404
38MP0010368_abnormal_lymphatic_system1.96459779
39MP0000647_abnormal_sebaceous_gland1.92965103
40MP0004947_skin_inflammation1.92153288
41MP0010678_abnormal_skin_adnexa1.91919695
42MP0000751_myopathy1.91577190
43MP0004233_abnormal_muscle_weight1.90984785
44MP0003453_abnormal_keratinocyte_physiol1.90086770
45MP0004272_abnormal_basement_membrane1.86121729
46MP0002166_altered_tumor_susceptibility1.85629506
47MP0003705_abnormal_hypodermis_morpholog1.82668623
48MP0001849_ear_inflammation1.80825969
49MP0006082_CNS_inflammation1.80307403
50MP0003828_pulmonary_edema1.77689463
51MP0000377_abnormal_hair_follicle1.74439908
52MP0005164_abnormal_response_to1.69188647
53MP0003136_yellow_coat_color1.67132893
54MP0001853_heart_inflammation1.65290217
55MP0000569_abnormal_digit_pigmentation1.63350320
56MP0002102_abnormal_ear_morphology1.62758134
57MP0005410_abnormal_fertilization1.62684052
58MP0009840_abnormal_foam_cell1.59110194
59MP0008438_abnormal_cutaneous_collagen1.57670585
60MP0005058_abnormal_lysosome_morphology1.53745242
61MP0000733_abnormal_muscle_development1.50932758
62MP0002269_muscular_atrophy1.46764450
63MP0003646_muscle_fatigue1.43840754
64MP0003763_abnormal_thymus_physiology1.39762802
65MP0001191_abnormal_skin_condition1.37960906
66MP0001986_abnormal_taste_sensitivity1.37347657
67MP0010094_abnormal_chromosome_stability1.33811097
68MP0002006_tumorigenesis1.31662395
69MP0005165_increased_susceptibility_to1.27682829
70MP0000858_altered_metastatic_potential1.27045942
71MP0003566_abnormal_cell_adhesion1.26035682
72MP0002148_abnormal_hypersensitivity_rea1.24050727
73MP0000372_irregular_coat_pigmentation1.22611416
74MP0009931_abnormal_skin_appearance1.21184140
75MP0006054_spinal_hemorrhage1.20971963
76MP0009379_abnormal_foot_pigmentation1.20758357
77MP0002735_abnormal_chemical_nociception1.18782742
78MP0004808_abnormal_hematopoietic_stem1.18191289
79MP0005174_abnormal_tail_pigmentation1.17888230
80MP0000747_muscle_weakness1.16933327
81MP0000566_synostosis1.16776866
82MP0005076_abnormal_cell_differentiation1.16549461
83MP0002233_abnormal_nose_morphology1.15891403
84MP0004858_abnormal_nervous_system1.11105710
85MP0000685_abnormal_immune_system1.10792474
86MP0000490_abnormal_crypts_of1.09487719
87MP0000358_abnormal_cell_content/1.08378394
88MP0000759_abnormal_skeletal_muscle1.07974160
89MP0002282_abnormal_trachea_morphology1.07880287
90MP0003075_altered_response_to1.07337090
91MP0009250_abnormal_appendicular_skeleto1.06275361
92MP0003221_abnormal_cardiomyocyte_apopto1.05267047
93MP0001243_abnormal_dermal_layer1.04322259
94MP0001542_abnormal_bone_strength1.04245317
95MP0001879_abnormal_lymphatic_vessel1.03560714
96MP0001270_distended_abdomen1.02782990
97MP0002095_abnormal_skin_pigmentation1.02055265
98MP0001340_abnormal_eyelid_morphology1.01830228
99MP0005389_reproductive_system_phenotype1.01130747
100MP0008789_abnormal_olfactory_epithelium1.00961763
101* MP0002419_abnormal_innate_immunity1.00783785
102MP0004087_abnormal_muscle_fiber1.00272628
103MP0003111_abnormal_nucleus_morphology0.97431935
104MP0003656_abnormal_erythrocyte_physiolo0.97186953
105MP0005360_urolithiasis0.96989670
106MP0005670_abnormal_white_adipose0.96424995
107MP0003724_increased_susceptibility_to0.96188015
108MP0003755_abnormal_palate_morphology0.96132522
109MP0005621_abnormal_cell_physiology0.95050821
110MP0005266_abnormal_metabolism0.93361057
111MP0005330_cardiomyopathy0.93163963
112MP0002998_abnormal_bone_remodeling0.93006310
113MP0009278_abnormal_bone_marrow0.92730275
114MP0009785_altered_susceptibility_to0.92510109
115MP0003448_altered_tumor_morphology0.92468177
116MP0002896_abnormal_bone_mineralization0.90952031
117MP0005197_abnormal_uvea_morphology0.89302357
118MP0005464_abnormal_platelet_physiology0.89229958
119MP0010352_gastrointestinal_tract_polyps0.87767434
120MP0000470_abnormal_stomach_morphology0.87428480
121MP0009764_decreased_sensitivity_to0.87354063
122MP0009053_abnormal_anal_canal0.85886802
123MP0001533_abnormal_skeleton_physiology0.85275121
124MP0005595_abnormal_vascular_smooth0.84868816
125MP0010155_abnormal_intestine_physiology0.84703296
126MP0003300_gastrointestinal_ulcer0.81879225
127MP0000538_abnormal_urinary_bladder0.81800388
128MP0005275_abnormal_skin_tensile0.80064875
129MP0000249_abnormal_blood_vessel0.79896590
130MP0008007_abnormal_cellular_replicative0.79888370
131MP0000613_abnormal_salivary_gland0.79836563
132MP0001299_abnormal_eye_distance/0.78973695
133MP0009765_abnormal_xenobiotic_induced0.78922563
134MP0000627_abnormal_mammary_gland0.78836312
135MP0000428_abnormal_craniofacial_morphol0.78520716
136MP0002234_abnormal_pharynx_morphology0.77669611
137* MP0002452_abnormal_antigen_presenting0.76837041
138MP0003045_fibrosis0.76726050
139MP0005310_abnormal_salivary_gland0.76547837
140MP0002106_abnormal_muscle_physiology0.76184838
141MP0003195_calcinosis0.75975938
142MP0002163_abnormal_gland_morphology0.74918847
143MP0003077_abnormal_cell_cycle0.74825437
144MP0002972_abnormal_cardiac_muscle0.74632412
145MP0005023_abnormal_wound_healing0.73316765
146MP0005376_homeostasis/metabolism_phenot0.72648139
147MP0001348_abnormal_lacrimal_gland0.72394017
148MP0001545_abnormal_hematopoietic_system0.72030233
149MP0005397_hematopoietic_system_phenotyp0.72030233
150MP0000367_abnormal_coat/_hair0.69736656
151MP0010030_abnormal_orbit_morphology0.68353669
152MP0002177_abnormal_outer_ear0.68056830
153MP0001529_abnormal_vocalization0.68018168
154MP0000681_abnormal_thyroid_gland0.67485400
155MP0005000_abnormal_immune_tolerance0.66947647
156MP0003718_maternal_effect0.66512744
157MP0000343_altered_response_to0.66486567
158MP0001835_abnormal_antigen_presentation0.65574200
159MP0003011_delayed_dark_adaptation0.65436672
160MP0005379_endocrine/exocrine_gland_phen0.61735924
161MP0005508_abnormal_skeleton_morphology0.58586984
162MP0003436_decreased_susceptibility_to0.57521307
163MP0004957_abnormal_blastocyst_morpholog0.57261618
164MP0009333_abnormal_splenocyte_physiolog0.55894195
165MP0005409_darkened_coat_color0.55888551
166MP0002019_abnormal_tumor_incidence0.55657681
167MP0008057_abnormal_DNA_replication0.54888128
168MP0002109_abnormal_limb_morphology0.54645538
169MP0000049_abnormal_middle_ear0.53469246
170MP0003693_abnormal_embryo_hatching0.52698639
171MP0008260_abnormal_autophagy0.51840974

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)8.83927509
2Plantar hyperkeratosis (HP:0007556)6.11900567
3Abnormality of cells of the erythroid lineage (HP:0012130)5.48062723
4Abnormal number of erythroid precursors (HP:0012131)4.95552179
5Short nail (HP:0001799)4.56022799
6Milia (HP:0001056)4.53144510
7Nemaline bodies (HP:0003798)3.92438720
8Osteolytic defects of the phalanges of the hand (HP:0009771)3.83402086
9Osteolytic defects of the hand bones (HP:0009699)3.83402086
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.77183720
11* Amyloidosis (HP:0011034)3.72056291
12Down-sloping shoulders (HP:0200021)3.61568678
13Muscle fiber inclusion bodies (HP:0100299)3.60496779
14Fatigue (HP:0012378)3.59890777
15Xerostomia (HP:0000217)3.57942364
16Abnormal blistering of the skin (HP:0008066)3.55232260
17Reticulocytopenia (HP:0001896)3.54887315
18Premature rupture of membranes (HP:0001788)3.52210999
19Hypoplastic labia majora (HP:0000059)3.51747026
20Reduced subcutaneous adipose tissue (HP:0003758)3.46672588
21Glucose intolerance (HP:0000833)3.39949736
22Hypotrichosis (HP:0001006)3.38237027
23Upper limb muscle weakness (HP:0003484)3.29102218
2411 pairs of ribs (HP:0000878)3.22916515
25Distal lower limb muscle weakness (HP:0009053)3.22734170
26Chronic obstructive pulmonary disease (HP:0006510)3.19505738
27Obstructive lung disease (HP:0006536)3.19505738
28Abnormality of the labia majora (HP:0012881)3.16025533
29Erythema (HP:0010783)3.10064462
30Pili torti (HP:0003777)3.07131204
31Difficulty climbing stairs (HP:0003551)3.06005714
32Limb-girdle muscle atrophy (HP:0003797)3.04271308
33Myocardial infarction (HP:0001658)3.01782864
34Vertebral compression fractures (HP:0002953)2.99708146
35Atrophic scars (HP:0001075)2.99564033
36Premature skin wrinkling (HP:0100678)2.96261831
37Conical tooth (HP:0000698)2.93844487
38Parakeratosis (HP:0001036)2.93597375
39Palmoplantar hyperkeratosis (HP:0000972)2.92858174
40Chin dimple (HP:0010751)2.88252546
41Increased connective tissue (HP:0009025)2.84016402
42Vascular calcification (HP:0004934)2.82859428
43Distal lower limb amyotrophy (HP:0008944)2.81983908
44Nail dystrophy (HP:0008404)2.81768962
45Volvulus (HP:0002580)2.81329771
46Syringomyelia (HP:0003396)2.79236837
47Spinal cord lesions (HP:0100561)2.79236837
48Thick nail (HP:0001805)2.78014962
49Abnormal hemoglobin (HP:0011902)2.74849879
50Congenital malformation of the right heart (HP:0011723)2.74449716
51Double outlet right ventricle (HP:0001719)2.74449716
52Shoulder girdle muscle weakness (HP:0003547)2.73868963
53Broad face (HP:0000283)2.73527965
54Abnormality of glycolipid metabolism (HP:0010969)2.71949293
55Abnormality of liposaccharide metabolism (HP:0010968)2.71949293
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.71949293
57Myositis (HP:0100614)2.71868051
58Palmar hyperkeratosis (HP:0010765)2.68743355
59Abnormality of the parathyroid morphology (HP:0011766)2.68116081
60Cardiovascular calcification (HP:0011915)2.61310231
61Concave nail (HP:0001598)2.61198263
62Hypodontia (HP:0000668)2.61047362
63Pustule (HP:0200039)2.59912160
64Aplasia/Hypoplasia of the earlobes (HP:0009906)2.59343600
65Spondylolisthesis (HP:0003302)2.57370419
66Termporal pattern (HP:0011008)2.53779881
67Insidious onset (HP:0003587)2.53779881
68Absent eyebrow (HP:0002223)2.53453162
69Poikiloderma (HP:0001029)2.52286925
70Lip pit (HP:0100267)2.51081662
71Pelvic girdle muscle weakness (HP:0003749)2.49155445
72Abnormality of the hip-girdle musculature (HP:0001445)2.48089022
73Abnormality of the musculature of the pelvis (HP:0001469)2.48089022
74Arterial tortuosity (HP:0005116)2.48061349
75Orthostatic hypotension (HP:0001278)2.47410362
76Ankyloglossia (HP:0010296)2.47075994
77Pallor (HP:0000980)2.46160899
78Onycholysis (HP:0001806)2.44483825
79Spinal rigidity (HP:0003306)2.43643217
80Asymmetric septal hypertrophy (HP:0001670)2.35630401
81Exercise-induced muscle cramps (HP:0003710)2.33877495
82Ectropion (HP:0000656)2.32996681
83Progressive sensorineural hearing impairment (HP:0000408)2.32887215
84Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.32124878
85Thrombocytosis (HP:0001894)2.31962422
86Ridged nail (HP:0001807)2.31788671
87Tetraparesis (HP:0002273)2.31236069
88Aplasia/Hypoplasia of the scapulae (HP:0006713)2.31108048
89Hypoplastic scapulae (HP:0000882)2.31108048
90Abnormality of the aortic arch (HP:0012303)2.29622704
91Abnormality of the dental root (HP:0006486)2.26785265
92Taurodontia (HP:0000679)2.26785265
93Abnormality of permanent molar morphology (HP:0011071)2.26785265
94Right ventricular cardiomyopathy (HP:0011663)2.25629548
95Popliteal pterygium (HP:0009756)2.25451295
96Bronchomalacia (HP:0002780)2.24029408
97Anhidrosis (HP:0000970)2.23196334
98EMG: myopathic abnormalities (HP:0003458)2.22882509
99Neck muscle weakness (HP:0000467)2.21918181
100Hyperhidrosis (HP:0000975)2.18843778
101Hypoplastic female external genitalia (HP:0012815)2.18445699
102Entropion (HP:0000621)2.18383913
103Sparse eyelashes (HP:0000653)2.18343451
104Decreased subcutaneous fat (HP:0001002)2.18026557
105Insulin resistance (HP:0000855)2.16731365
106Interstitial pulmonary disease (HP:0006530)2.16191229
107Mitral stenosis (HP:0001718)2.15363410
108Woolly hair (HP:0002224)2.12321960
109Orchitis (HP:0100796)2.11659153
110Hypoplasia of dental enamel (HP:0006297)2.11463821
111Abnormality of the phalanges of the 5th finger (HP:0004213)2.09165392
112Eczematoid dermatitis (HP:0000976)2.08246893
113Labial hypoplasia (HP:0000066)2.07046216
114Abnormality of molar (HP:0011077)2.06519772
115Abnormality of molar morphology (HP:0011070)2.06519772
116Sparse scalp hair (HP:0002209)2.05980769
117Rhabdomyolysis (HP:0003201)2.05879102
118Aqueductal stenosis (HP:0002410)2.04504802
119Macrocytic anemia (HP:0001972)2.04133689
120Vascular tortuosity (HP:0004948)2.03901347
121Premature loss of primary teeth (HP:0006323)2.03539764
122Progressive hearing impairment (HP:0001730)2.03207296
123Myoglobinuria (HP:0002913)2.01869343
124Abnormal glucose tolerance (HP:0001952)2.00531833
125Abnormality of the umbilical cord (HP:0010881)2.00457148
126Wormian bones (HP:0002645)1.99381823
127Follicular hyperkeratosis (HP:0007502)1.98788819
128Limb-girdle muscle weakness (HP:0003325)1.95966406
129Abnormality of the labia (HP:0000058)1.95354096
130Muscular dystrophy (HP:0003560)1.94504536
131Increased IgE level (HP:0003212)1.93873000
132Abnormality of the dental pulp (HP:0006479)1.93316577
133Seborrheic dermatitis (HP:0001051)1.92960691
134Abnormality of the distal phalanges of the toes (HP:0010182)1.92788303
135Blepharitis (HP:0000498)1.92539798
136Abnormality of the musculature of the hand (HP:0001421)1.92244010
137Generalized amyotrophy (HP:0003700)1.91784714
138Carious teeth (HP:0000670)1.91744504
139Shallow orbits (HP:0000586)1.89812605
140Stenosis of the external auditory canal (HP:0000402)1.89669073
141Nuclear cataract (HP:0100018)1.89086568
142Nasolacrimal duct obstruction (HP:0000579)1.88863492
143Choroideremia (HP:0001139)1.87473346
144Bilateral sensorineural hearing impairment (HP:0008619)1.86821103
145Abnormality of lateral ventricle (HP:0030047)1.86319270
146Abnormality of the labia minora (HP:0012880)1.86180147
147Flattened epiphyses (HP:0003071)1.85699771
148Achilles tendon contracture (HP:0001771)1.85564425
149Type 1 muscle fiber predominance (HP:0003803)1.85219675
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.85176266
151Abnormality of the intrinsic pathway (HP:0010989)1.85060590
152Alopecia of scalp (HP:0002293)1.84812174
153Recurrent abscess formation (HP:0002722)1.83981810
154Abnormality of the preputium (HP:0100587)1.83931839
155Abnormality of the pericardium (HP:0001697)1.83807180
156Abnormality of the middle phalanges of the toes (HP:0010183)1.83716411
157Neurofibrillary tangles (HP:0002185)1.82228480
158Lower limb amyotrophy (HP:0007210)1.82224894
159Abnormality of oral frenula (HP:0000190)1.80977652
160Elbow flexion contracture (HP:0002987)1.80087693
161Periodontitis (HP:0000704)1.79397426
162Abnormal sex determination (HP:0012244)1.78751002
163Sex reversal (HP:0012245)1.78751002
164Abnormal autonomic nervous system physiology (HP:0012332)1.78166580
165Unilateral renal agenesis (HP:0000122)1.77926759
166Reduced antithrombin III activity (HP:0001976)1.77783978
167Type I transferrin isoform profile (HP:0003642)1.77744733
168Abnormal spermatogenesis (HP:0008669)1.77427095
169Abnormality of macrophages (HP:0004311)1.75157440
170Recurrent bacterial skin infections (HP:0005406)1.74941306
171Esophageal atresia (HP:0002032)1.74007284
172Elevated erythrocyte sedimentation rate (HP:0003565)1.73390469
173Selective tooth agenesis (HP:0001592)1.72899030
174Cerebral inclusion bodies (HP:0100314)1.72547868
175Aplasia involving bones of the upper limbs (HP:0009823)1.71862384
176Aplasia of the phalanges of the hand (HP:0009802)1.71862384
177Aplasia involving bones of the extremities (HP:0009825)1.71862384
178Upper limb amyotrophy (HP:0009129)1.71658121
179Distal upper limb amyotrophy (HP:0007149)1.71658121
180Autoimmune thrombocytopenia (HP:0001973)1.70399992
181Exercise-induced myalgia (HP:0003738)1.69397670
182Long toe (HP:0010511)1.68742465
183Cone-rod dystrophy (HP:0000548)1.67632351
184Increased serum ferritin (HP:0003281)1.66829242
185Hand muscle atrophy (HP:0009130)1.66703697
186Abnormality of the sella turcica (HP:0002679)1.63185738
187Large earlobe (HP:0009748)1.62845250
188Natal tooth (HP:0000695)1.61387375
189Abnormality of the common coagulation pathway (HP:0010990)1.61107326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.93859356
2MAP3K33.86986483
3MAPKAPK33.67292476
4MAP3K23.35769885
5EEF2K3.25010435
6EPHA23.17314323
7MAP3K62.97577165
8MET2.88204464
9FGFR22.65889654
10ERN12.54668501
11LIMK12.46564601
12BMPR22.39382386
13NME22.36780696
14ERBB42.35282784
15TTN2.30334304
16TTK2.14963692
17RPS6KB22.14585187
18LATS12.12726597
19PBK2.09710502
20CLK12.06376156
21TESK12.02254719
22PIM22.01195002
23PTK21.98540197
24PAK41.93520533
25LMTK21.90419744
26TESK21.89064114
27LRRK21.87113589
28LATS21.85857595
29BMPR1B1.83807474
30MAP3K141.78470575
31ARAF1.77838793
32PTK2B1.75769528
33TAOK31.69281984
34TGFBR21.68814686
35HIPK21.65006758
36KIT1.54184630
37STK241.52807284
38BUB11.45737068
39CDK121.42346712
40PLK41.42182824
41MAPKAPK51.42001589
42ICK1.40494149
43SCYL21.39078233
44CSF1R1.39069904
45MAP3K121.37297524
46PAK61.25969966
47RAF11.25718250
48MAP3K131.24574103
49EIF2AK31.18807628
50MAPK111.18282736
51TRPM71.17951523
52ERBB31.17141802
53STK31.17054178
54CAMKK21.11848037
55STK381.11590070
56BRAF1.11489323
57KSR11.10923471
58GRK71.10380707
59CDC71.07165379
60TAOK21.06798998
61EPHA31.06649128
62SIK31.05691684
63PNCK1.02436585
64RPS6KL11.01020053
65RPS6KC11.01020053
66BRSK20.99886572
67ABL20.99743008
68RPS6KA20.98590827
69RIPK40.98201040
70EIF2AK10.97902098
71NEK20.97318697
72IRAK40.96333010
73TEC0.94015748
74PIK3CG0.92531788
75TYK20.92018010
76FLT30.91505960
77RET0.90911055
78NEK10.89533593
79PDGFRA0.88926752
80CAMKK10.87481121
81PDGFRB0.87413953
82MAPK130.84734796
83ZAP700.84265354
84JAK20.83046729
85RPS6KA60.81686457
86AURKB0.80807060
87MAPK40.80392075
88BTK0.80378158
89TRIM280.77917209
90PRKD20.75248332
91NTRK10.74537206
92MAP2K30.74471299
93DMPK0.73854114
94OBSCN0.73804878
95KSR20.73651093
96EPHB10.72736598
97MAP3K80.72676406
98PHKG10.72209988
99PHKG20.72209988
100YES10.72097652
101NLK0.67823738
102DYRK20.63751356
103IKBKB0.63682796
104ADRBK10.63161727
105PRKCH0.62364646
106FGFR30.61195883
107STK100.60705588
108PLK20.60122314
109MOS0.60107190
110CHEK20.59561977
111GSK3A0.58850937
112CDK80.58836757
113TNIK0.58389471
114FES0.58388072
115BMX0.57850990
116STK38L0.57566513
117PAK20.57475739
118BCR0.56789296
119NUAK10.56402345
120TBK10.56302170
121EPHB20.55677439
122MATK0.55461313
123JAK30.54970082
124MAP2K40.54806858
125FGFR10.53521430
126NTRK20.52448535
127STK110.52052383
128MAPKAPK20.51258988
129DAPK20.50234560
130MYLK0.50197980
131PAK10.48802758
132ILK0.48088095
133CDK90.47652365
134IRAK10.46080623
135BRSK10.46026533
136SRPK10.45858513
137DDR20.43901852
138MAP2K70.43754231
139ROCK10.42698178
140ATM0.42605694
141CSNK1D0.41849323
142ABL10.40095218
143MINK10.40092261
144CSNK1G20.39349420
145ITK0.39177249
146MAP2K10.38818981
147IRAK20.38581283
148CDK70.38571489
149MST1R0.38493592
150PRKCI0.38115936
151VRK10.37441978
152PIM10.37383007
153MAPK30.37173542
154MAP3K90.36866191
155MTOR0.36771819
156FGR0.34361608
157JAK10.33754911
158MELK0.33179795
159CAMK1G0.32542731
160NEK90.31720396

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.36860456
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.95866717
3DNA replication_Homo sapiens_hsa030302.92667712
4Other glycan degradation_Homo sapiens_hsa005112.49036797
5Non-homologous end-joining_Homo sapiens_hsa034502.42062650
6p53 signaling pathway_Homo sapiens_hsa041152.32276337
7Legionellosis_Homo sapiens_hsa051342.23623690
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21614536
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08718568
10Cell cycle_Homo sapiens_hsa041102.05523811
11Shigellosis_Homo sapiens_hsa051311.97902228
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95358519
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93974652
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89119556
15Toxoplasmosis_Homo sapiens_hsa051451.86299743
16Leishmaniasis_Homo sapiens_hsa051401.85000713
17Mismatch repair_Homo sapiens_hsa034301.76910906
18Bladder cancer_Homo sapiens_hsa052191.70495003
19Homologous recombination_Homo sapiens_hsa034401.68067315
20Protein digestion and absorption_Homo sapiens_hsa049741.66192101
21RNA degradation_Homo sapiens_hsa030181.62188985
22Focal adhesion_Homo sapiens_hsa045101.61844251
23African trypanosomiasis_Homo sapiens_hsa051431.56292666
24Proteasome_Homo sapiens_hsa030501.54822171
25Amoebiasis_Homo sapiens_hsa051461.53579908
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49579908
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49150502
28Nucleotide excision repair_Homo sapiens_hsa034201.48080086
29N-Glycan biosynthesis_Homo sapiens_hsa005101.42237683
30Influenza A_Homo sapiens_hsa051641.41558279
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40078530
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38954198
33Pentose phosphate pathway_Homo sapiens_hsa000301.35789624
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35066067
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35062140
36Ovarian steroidogenesis_Homo sapiens_hsa049131.34227572
37Pancreatic cancer_Homo sapiens_hsa052121.33997229
38Base excision repair_Homo sapiens_hsa034101.27568159
39Dorso-ventral axis formation_Homo sapiens_hsa043201.26693520
40Fanconi anemia pathway_Homo sapiens_hsa034601.25646193
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24149471
42Galactose metabolism_Homo sapiens_hsa000521.22799494
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22668362
44Adherens junction_Homo sapiens_hsa045201.20285061
45Oocyte meiosis_Homo sapiens_hsa041141.19670167
46Tuberculosis_Homo sapiens_hsa051521.19046518
47Dilated cardiomyopathy_Homo sapiens_hsa054141.17688947
48Sphingolipid metabolism_Homo sapiens_hsa006001.14657114
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12654645
50ECM-receptor interaction_Homo sapiens_hsa045121.09240766
51Pertussis_Homo sapiens_hsa051331.08974519
52TGF-beta signaling pathway_Homo sapiens_hsa043501.08031977
53Lysosome_Homo sapiens_hsa041421.07733026
54Acute myeloid leukemia_Homo sapiens_hsa052211.07560077
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07475926
56Renal cell carcinoma_Homo sapiens_hsa052111.06411206
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05845647
58Hematopoietic cell lineage_Homo sapiens_hsa046401.05041583
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04281255
60Apoptosis_Homo sapiens_hsa042101.01658896
61Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01392344
62Chronic myeloid leukemia_Homo sapiens_hsa052201.00476294
63Thyroid cancer_Homo sapiens_hsa052160.95563689
64Measles_Homo sapiens_hsa051620.94182975
65Malaria_Homo sapiens_hsa051440.92244666
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91651084
67Small cell lung cancer_Homo sapiens_hsa052220.90039218
68Melanoma_Homo sapiens_hsa052180.87131190
69Pathways in cancer_Homo sapiens_hsa052000.84472854
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82958897
71Basal cell carcinoma_Homo sapiens_hsa052170.81213395
72Platelet activation_Homo sapiens_hsa046110.80784804
73MicroRNAs in cancer_Homo sapiens_hsa052060.80116203
74Salivary secretion_Homo sapiens_hsa049700.79438217
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.79276518
76Fructose and mannose metabolism_Homo sapiens_hsa000510.77428659
77VEGF signaling pathway_Homo sapiens_hsa043700.77036347
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76148393
79Circadian rhythm_Homo sapiens_hsa047100.75843806
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75465683
81Viral carcinogenesis_Homo sapiens_hsa052030.75230969
82Viral myocarditis_Homo sapiens_hsa054160.75118852
83Pyrimidine metabolism_Homo sapiens_hsa002400.74758023
84B cell receptor signaling pathway_Homo sapiens_hsa046620.74413869
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.74360284
86Taste transduction_Homo sapiens_hsa047420.73169083
87Colorectal cancer_Homo sapiens_hsa052100.72952476
88Osteoclast differentiation_Homo sapiens_hsa043800.72756796
89Basal transcription factors_Homo sapiens_hsa030220.72268732
90Gastric acid secretion_Homo sapiens_hsa049710.71947275
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.71297373
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69337209
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68604999
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68430178
95Salmonella infection_Homo sapiens_hsa051320.67821885
96Histidine metabolism_Homo sapiens_hsa003400.67032823
97Endocytosis_Homo sapiens_hsa041440.66692527
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66545587
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66134138
100Hepatitis B_Homo sapiens_hsa051610.65736403
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65388598
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64945630
103Serotonergic synapse_Homo sapiens_hsa047260.64775138
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63309071
105Primary immunodeficiency_Homo sapiens_hsa053400.63187088
106RNA transport_Homo sapiens_hsa030130.63002074
107Prolactin signaling pathway_Homo sapiens_hsa049170.62618718
108ErbB signaling pathway_Homo sapiens_hsa040120.62521250
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.60198374
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59986305
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59847319
112Glutathione metabolism_Homo sapiens_hsa004800.59306581
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59162136
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57931440
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57292050
116Herpes simplex infection_Homo sapiens_hsa051680.55739934
117ABC transporters_Homo sapiens_hsa020100.55258566
118Antigen processing and presentation_Homo sapiens_hsa046120.54619691
119Wnt signaling pathway_Homo sapiens_hsa043100.53971566
120Phagosome_Homo sapiens_hsa041450.53415716
121Folate biosynthesis_Homo sapiens_hsa007900.52458241
122HIF-1 signaling pathway_Homo sapiens_hsa040660.52138820
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.51947596
124Purine metabolism_Homo sapiens_hsa002300.50200879
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.50185849
126FoxO signaling pathway_Homo sapiens_hsa040680.49819404
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48893242
128Hepatitis C_Homo sapiens_hsa051600.47825027
129Long-term depression_Homo sapiens_hsa047300.47441541
130Hippo signaling pathway_Homo sapiens_hsa043900.46819054
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46534822
132Epstein-Barr virus infection_Homo sapiens_hsa051690.46423008
133Insulin resistance_Homo sapiens_hsa049310.46205340
134cAMP signaling pathway_Homo sapiens_hsa040240.45019043
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44545937
136GnRH signaling pathway_Homo sapiens_hsa049120.44516427
137Notch signaling pathway_Homo sapiens_hsa043300.44098881
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43789932
139Non-small cell lung cancer_Homo sapiens_hsa052230.43750089
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.42896146
141Renin-angiotensin system_Homo sapiens_hsa046140.42889060
142Sulfur metabolism_Homo sapiens_hsa009200.42505646
143Endometrial cancer_Homo sapiens_hsa052130.41855518
144Rap1 signaling pathway_Homo sapiens_hsa040150.41710560
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40804407
146Phototransduction_Homo sapiens_hsa047440.40778323
147Glioma_Homo sapiens_hsa052140.40683843
148Proteoglycans in cancer_Homo sapiens_hsa052050.40091629
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40041600
150Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38225623
151TNF signaling pathway_Homo sapiens_hsa046680.37912150

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