IL32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.12243092
2cytidine metabolic process (GO:0046087)8.12243092
3cytidine catabolic process (GO:0006216)8.12243092
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.32973630
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.66349988
6DNA deamination (GO:0045006)5.91014669
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88951294
8cellular response to interleukin-15 (GO:0071350)5.83901360
9negative T cell selection (GO:0043383)5.62462508
10positive regulation of gamma-delta T cell activation (GO:0046645)5.40752530
11response to interleukin-15 (GO:0070672)5.33597490
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.18414381
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.14398306
14regulation of regulatory T cell differentiation (GO:0045589)5.13147281
15T cell migration (GO:0072678)5.04906384
16negative thymic T cell selection (GO:0045060)4.97984909
17positive thymic T cell selection (GO:0045059)4.90586293
18positive T cell selection (GO:0043368)4.87224447
19negative regulation of cell killing (GO:0031342)4.87009055
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.87009055
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85875635
22regulation of B cell receptor signaling pathway (GO:0050855)4.83577472
23regulation of gamma-delta T cell differentiation (GO:0045586)4.81670582
24Arp2/3 complex-mediated actin nucleation (GO:0034314)4.81060989
25antigen processing and presentation of endogenous antigen (GO:0019883)4.74000913
26regulation of T cell tolerance induction (GO:0002664)4.73066965
27thymic T cell selection (GO:0045061)4.61278489
28regulation of natural killer cell mediated immunity (GO:0002715)4.51725837
29regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.51725837
30positive regulation of natural killer cell mediated immunity (GO:0002717)4.49815693
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.42045063
32positive regulation of tolerance induction (GO:0002645)4.29299190
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.28554081
34regulation of gamma-delta T cell activation (GO:0046643)4.26438784
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.21800288
36regulation of leukocyte mediated cytotoxicity (GO:0001910)4.19462473
37actin nucleation (GO:0045010)4.15585719
38T cell selection (GO:0045058)4.14531914
39positive regulation of T cell mediated cytotoxicity (GO:0001916)4.12491281
40negative regulation of T cell apoptotic process (GO:0070233)4.05023397
41regulation of T cell mediated cytotoxicity (GO:0001914)4.02085821
42T cell costimulation (GO:0031295)4.00764099
43positive regulation of cell killing (GO:0031343)3.98604063
44lymphocyte costimulation (GO:0031294)3.95434005
45T cell receptor signaling pathway (GO:0050852)3.93244742
46positive regulation of calcium-mediated signaling (GO:0050850)3.92674031
47negative regulation of viral genome replication (GO:0045071)3.88809040
48regulation of activation of Janus kinase activity (GO:0010533)3.87016002
49regulation of alpha-beta T cell proliferation (GO:0046640)3.84372510
50regulation of cell killing (GO:0031341)3.84341852
51regulation of tolerance induction (GO:0002643)3.83409160
52pyrimidine nucleoside catabolic process (GO:0046135)3.73701378
53regulation of interleukin-2 biosynthetic process (GO:0045076)3.73289480
54positive regulation of interleukin-8 secretion (GO:2000484)3.69952462
55cytolysis (GO:0019835)3.64393949
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.64162901
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.62716369
58dendritic cell chemotaxis (GO:0002407)3.59660024
59lymphocyte chemotaxis (GO:0048247)3.59044184
60eosinophil chemotaxis (GO:0048245)3.56577288
61regulation of T cell receptor signaling pathway (GO:0050856)3.54180506
62antigen receptor-mediated signaling pathway (GO:0050851)3.53088837
63regulation of lymphocyte chemotaxis (GO:1901623)3.52709857
64regulation of B cell differentiation (GO:0045577)3.51089222
65positive regulation of B cell differentiation (GO:0045579)3.50581208
66regulation of isotype switching to IgG isotypes (GO:0048302)3.50180857
67regulation of chronic inflammatory response (GO:0002676)3.44851481
68NIK/NF-kappaB signaling (GO:0038061)3.41094011
69tolerance induction (GO:0002507)3.40010645
70negative regulation by host of viral transcription (GO:0043922)3.37025295
71lymphocyte migration (GO:0072676)3.36642534
72antigen processing and presentation via MHC class Ib (GO:0002475)3.33424093
73positive regulation of lymphocyte migration (GO:2000403)3.32072362
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31230054
75positive regulation of T cell chemotaxis (GO:0010820)3.24699735
76regulation of T cell chemotaxis (GO:0010819)3.24699735
77type I interferon signaling pathway (GO:0060337)3.24235446
78cellular response to type I interferon (GO:0071357)3.24235446
79response to type I interferon (GO:0034340)3.20447887
80positive regulation of interleukin-4 production (GO:0032753)3.20447692
81leukocyte aggregation (GO:0070486)3.19809881
82eosinophil migration (GO:0072677)3.18806637
83macrophage chemotaxis (GO:0048246)3.17933028
84positive regulation of defense response to virus by host (GO:0002230)3.17800575
85cellular defense response (GO:0006968)3.13343544
86activated T cell proliferation (GO:0050798)3.13167724
87negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.05951398
88dendritic cell migration (GO:0036336)3.05590473
89positive regulation of T cell mediated immunity (GO:0002711)3.04719085
90chemokine-mediated signaling pathway (GO:0070098)3.03995097
91regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01561477
92positive regulation of lymphocyte mediated immunity (GO:0002708)3.01238833
93immunoglobulin mediated immune response (GO:0016064)3.00840928
94regulation of T cell apoptotic process (GO:0070232)2.97787652
95regulation of lymphocyte migration (GO:2000401)2.96577417
96regulation of interleukin-8 secretion (GO:2000482)2.89593314
97response to interferon-beta (GO:0035456)2.88149817
98negative regulation of leukocyte mediated immunity (GO:0002704)2.84233537
99regulation of viral genome replication (GO:0045069)2.83392827
100positive regulation of T cell migration (GO:2000406)2.81620910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.49391270
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.72873375
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.63839946
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.35238084
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.95340290
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45047402
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.41110077
8RUNX_20019798_ChIP-Seq_JUKART_Human3.34881068
9* MYB_26560356_Chip-Seq_TH2_Human3.23591953
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.17934101
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82484909
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68604576
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65216935
14MYB_26560356_Chip-Seq_TH1_Human2.49838934
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41967129
16MAF_26560356_Chip-Seq_TH1_Human2.40747434
17* UTX_26944678_Chip-Seq_JUKART_Human2.35614425
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30698710
19* GATA3_27048872_Chip-Seq_THYMUS_Human2.24568181
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22762982
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18868645
22MAF_26560356_Chip-Seq_TH2_Human2.08524484
23GATA3_26560356_Chip-Seq_TH2_Human1.84874311
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83100893
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82609380
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.78703022
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72531537
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69762038
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67607567
30SPI1_23547873_ChIP-Seq_NB4_Human1.64733833
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64600707
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56153865
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.55348162
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52799745
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51845154
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46464449
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41204258
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.38400694
39* BCL6_27268052_Chip-Seq_Bcells_Human1.36513500
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35280387
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33505040
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32430217
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27075103
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26569768
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21657146
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19813223
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19714086
48VDR_24763502_ChIP-Seq_THP-1_Human1.17456162
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15413977
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14198028
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.13041987
52SPI1_23127762_ChIP-Seq_K562_Human1.10219299
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10107098
54* BCOR_27268052_Chip-Seq_Bcells_Human1.08322207
55MYC_22102868_ChIP-Seq_BL_Human1.06712509
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05187376
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05044886
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04865898
59SA1_27219007_Chip-Seq_Bcells_Human1.01059120
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99764712
61P300_27268052_Chip-Seq_Bcells_Human0.99290446
62RXR_22158963_ChIP-Seq_LIVER_Mouse0.96700886
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96652767
64* ELF1_20517297_ChIP-Seq_JURKAT_Human0.96510827
65CIITA_25753668_ChIP-Seq_RAJI_Human0.94612824
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94265355
67MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93321595
68* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92775151
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92577267
70* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91554667
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91221965
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88663024
73LXR_22292898_ChIP-Seq_THP-1_Human0.87636652
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87487021
75VDR_21846776_ChIP-Seq_THP-1_Human0.87001150
76SCL_19346495_ChIP-Seq_HPC-7_Human0.86176474
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86008288
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84651771
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84005828
80NANOG_20526341_ChIP-Seq_ESCs_Human0.83366758
81GATA1_22025678_ChIP-Seq_K562_Human0.81336228
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81246407
83CTCF_20526341_ChIP-Seq_ESCs_Human0.80902545
84SPI1_20517297_ChIP-Seq_HL60_Human0.80587559
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79216979
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77862823
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77435507
88* YY1_22570637_ChIP-Seq_MALME-3M_Human0.76596795
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76542819
90* TAF2_19829295_ChIP-Seq_ESCs_Human0.74133596
91VDR_23849224_ChIP-Seq_CD4+_Human0.73354410
92* GATA3_26560356_Chip-Seq_TH1_Human0.73006557
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72741470
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72356980
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71250651
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.70072296
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69568557
98* ELK3_25401928_ChIP-Seq_HUVEC_Human0.69359005
99ETS1_21867929_ChIP-Seq_TH2_Mouse0.69192833
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68842225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.92171816
2MP0003763_abnormal_thymus_physiology4.12115210
3MP0009785_altered_susceptibility_to3.65340610
4MP0001835_abnormal_antigen_presentation3.56271170
5MP0009333_abnormal_splenocyte_physiolog3.36944676
6MP0005000_abnormal_immune_tolerance3.17450037
7MP0001800_abnormal_humoral_immune3.09179970
8MP0003436_decreased_susceptibility_to2.94475153
9MP0005025_abnormal_response_to2.88648209
10MP0001790_abnormal_immune_system2.85161516
11MP0005387_immune_system_phenotype2.85161516
12MP0000685_abnormal_immune_system2.78307592
13MP0003866_abnormal_defecation2.75850865
14MP0002723_abnormal_immune_serum2.72309186
15MP0006082_CNS_inflammation2.71987617
16MP0002420_abnormal_adaptive_immunity2.64467422
17MP0010155_abnormal_intestine_physiology2.60303603
18MP0001819_abnormal_immune_cell2.59685723
19MP0002148_abnormal_hypersensitivity_rea2.54980575
20MP0001873_stomach_inflammation2.51284994
21MP0002166_altered_tumor_susceptibility2.49739184
22MP0002452_abnormal_antigen_presenting2.33800272
23MP0003724_increased_susceptibility_to2.32132155
24MP0005360_urolithiasis2.22463379
25MP0002398_abnormal_bone_marrow2.08662962
26MP0000716_abnormal_immune_system2.06840313
27MP0002419_abnormal_innate_immunity2.03931407
28MP0002405_respiratory_system_inflammati2.01512079
29MP0001845_abnormal_inflammatory_respons1.93733597
30MP0002933_joint_inflammation1.88880086
31MP0002138_abnormal_hepatobiliary_system1.87224161
32MP0000703_abnormal_thymus_morphology1.84555800
33MP0002006_tumorigenesis1.81049067
34MP0002139_abnormal_hepatobiliary_system1.75839598
35MP0004947_skin_inflammation1.74281363
36MP0002722_abnormal_immune_system1.73517410
37MP0000689_abnormal_spleen_morphology1.70003134
38MP0002429_abnormal_blood_cell1.60071946
39MP0008469_abnormal_protein_level1.50080045
40MP0003045_fibrosis1.48227826
41MP0005464_abnormal_platelet_physiology1.46638251
42MP0001533_abnormal_skeleton_physiology1.41696040
43MP0003448_altered_tumor_morphology1.38839614
44MP0005085_abnormal_gallbladder_physiolo1.35765786
45MP0001853_heart_inflammation1.32504274
46MP0001666_abnormal_nutrient_absorption1.31875591
47MP0003300_gastrointestinal_ulcer1.30279708
48MP0005365_abnormal_bile_salt1.25237177
49MP0005310_abnormal_salivary_gland1.24815659
50MP0003252_abnormal_bile_duct1.20681219
51MP0002277_abnormal_respiratory_mucosa1.18379412
52MP0005166_decreased_susceptibility_to1.16480327
53MP0009763_increased_sensitivity_to1.13797340
54MP0000858_altered_metastatic_potential1.09857802
55MP0009840_abnormal_foam_cell1.06354980
56MP0003183_abnormal_peptide_metabolism1.04999679
57MP0009764_decreased_sensitivity_to1.04501637
58MP0002876_abnormal_thyroid_physiology1.04195289
59MP0003806_abnormal_nucleotide_metabolis1.01679421
60MP0009643_abnormal_urine_homeostasis0.95473687
61MP0000465_gastrointestinal_hemorrhage0.91819406
62MP0004381_abnormal_hair_follicle0.88480562
63MP0002132_abnormal_respiratory_system0.85434985
64MP0000604_amyloidosis0.84771883
65MP0000490_abnormal_crypts_of0.81638199
66MP0002136_abnormal_kidney_physiology0.81145544
67MP0005075_abnormal_melanosome_morpholog0.81087375
68MP0002998_abnormal_bone_remodeling0.79846177
69MP0002693_abnormal_pancreas_physiology0.74239815
70MP0010329_abnormal_lipoprotein_level0.74227813
71MP0001765_abnormal_ion_homeostasis0.73332872
72MP0008875_abnormal_xenobiotic_pharmacok0.69304048
73MP0000609_abnormal_liver_physiology0.68569574
74MP0003075_altered_response_to0.68097669
75MP0001663_abnormal_digestive_system0.66693059
76MP0002019_abnormal_tumor_incidence0.65794201
77MP0009765_abnormal_xenobiotic_induced0.64501739
78MP0001919_abnormal_reproductive_system0.64347680
79MP0002163_abnormal_gland_morphology0.64096346
80MP0000249_abnormal_blood_vessel0.62450752
81MP0005584_abnormal_enzyme/coenzyme_acti0.61786505
82MP0003195_calcinosis0.59484137
83MP0001764_abnormal_homeostasis0.58203559
84MP0005377_hearing/vestibular/ear_phenot0.57714707
85MP0003878_abnormal_ear_physiology0.57714707
86MP0005332_abnormal_amino_acid0.56833071
87MP0005319_abnormal_enzyme/_coenzyme0.55556406
88MP0001851_eye_inflammation0.55053483
89MP0005636_abnormal_mineral_homeostasis0.55045222
90MP0000477_abnormal_intestine_morphology0.55023289
91MP0009642_abnormal_blood_homeostasis0.55019226
92MP0008872_abnormal_physiological_respon0.52152782
93MP0001661_extended_life_span0.51549213
94MP0005390_skeleton_phenotype0.50751908
95MP0002009_preneoplasia0.50705001
96MP0008873_increased_physiological_sensi0.49866298
97MP0003868_abnormal_feces_composition0.49031701
98MP0003303_peritoneal_inflammation0.48090303
99MP0004147_increased_porphyrin_level0.47847826
100MP0003795_abnormal_bone_structure0.47403724

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.97191869
2Abnormality of T cell number (HP:0011839)6.63168821
3Autoimmune hemolytic anemia (HP:0001890)5.12079035
4Abnormality of T cells (HP:0002843)5.05567902
5Elevated erythrocyte sedimentation rate (HP:0003565)4.93154589
6IgG deficiency (HP:0004315)4.84326293
7Chronic diarrhea (HP:0002028)4.58611842
8Severe combined immunodeficiency (HP:0004430)4.50194679
9Increased IgM level (HP:0003496)4.40399544
10Aplastic anemia (HP:0001915)4.13850546
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.13468186
12Stomatitis (HP:0010280)4.07007239
13Myositis (HP:0100614)3.81620188
14Abnormality of macrophages (HP:0004311)3.80811357
15Recurrent bronchitis (HP:0002837)3.73840448
16Abnormality of eosinophils (HP:0001879)3.68563257
17Encephalitis (HP:0002383)3.62280142
18Hypoproteinemia (HP:0003075)3.60514372
19Meningitis (HP:0001287)3.60486003
20Eczematoid dermatitis (HP:0000976)3.57413971
21Combined immunodeficiency (HP:0005387)3.56536753
22Joint swelling (HP:0001386)3.51923638
23Abnormality of T cell physiology (HP:0011840)3.45337866
24Pustule (HP:0200039)3.43125417
25Vasculitis (HP:0002633)3.42537068
26Recurrent fungal infections (HP:0002841)3.39427881
27Gastrointestinal infarctions (HP:0005244)3.39385980
28Lymphopenia (HP:0001888)3.37202330
29Pulmonary infiltrates (HP:0002113)3.37131137
30Recurrent viral infections (HP:0004429)3.28975101
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.28484285
32Retrobulbar optic neuritis (HP:0100654)3.27093553
33Optic neuritis (HP:0100653)3.27093553
34IgM deficiency (HP:0002850)3.24487834
35Eosinophilia (HP:0001880)3.24418863
36Obstructive lung disease (HP:0006536)3.22428508
37Chronic obstructive pulmonary disease (HP:0006510)3.22428508
38Chronic mucocutaneous candidiasis (HP:0002728)3.20938567
39Recurrent cutaneous fungal infections (HP:0011370)3.20938567
40Orchitis (HP:0100796)3.20859076
41Thyroiditis (HP:0100646)3.15153140
42Abnormality of the prostate (HP:0008775)3.13203481
43Leukocytosis (HP:0001974)3.04181988
44Granulocytopenia (HP:0001913)3.04118808
45Recurrent abscess formation (HP:0002722)2.91912756
46Autoimmune thrombocytopenia (HP:0001973)2.82061395
47Recurrent bacterial skin infections (HP:0005406)2.77440670
48Gangrene (HP:0100758)2.76421400
49Hemoptysis (HP:0002105)2.73699356
50Mediastinal lymphadenopathy (HP:0100721)2.73624723
51Chest pain (HP:0100749)2.73015023
52Abnormality of B cell number (HP:0010975)2.69802190
53Recurrent skin infections (HP:0001581)2.69525905
54Agammaglobulinemia (HP:0004432)2.68926964
55Hypergammaglobulinemia (HP:0010702)2.68661523
56Panhypogammaglobulinemia (HP:0003139)2.67002455
57Pulmonary embolism (HP:0002204)2.65941426
58Abnormality of the pleura (HP:0002103)2.46942677
59Keratoconjunctivitis sicca (HP:0001097)2.46019118
60Lymphoma (HP:0002665)2.40441071
61Hypoplasia of the thymus (HP:0000778)2.37631564
62B lymphocytopenia (HP:0010976)2.36551892
63IgA deficiency (HP:0002720)2.33045899
64Keratoconjunctivitis (HP:0001096)2.29987430
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26772472
66Bronchitis (HP:0012387)2.24415036
67Skin rash (HP:0000988)2.23319044
68Recurrent gram-negative bacterial infections (HP:0005420)2.22798526
69Acute hepatic failure (HP:0006554)2.22209765
70Increased IgE level (HP:0003212)2.18750092
71Inflammation of the large intestine (HP:0002037)2.14212174
72Systemic lupus erythematosus (HP:0002725)2.08158166
73Spontaneous hematomas (HP:0007420)2.05450076
74Ureteral stenosis (HP:0000071)2.05192368
75Pancreatitis (HP:0001733)2.04359466
76Abnormal albumin level (HP:0012116)2.04139791
77Hypoalbuminemia (HP:0003073)2.04139791
78Anorexia (HP:0002039)2.04139351
79Glomerulopathy (HP:0100820)1.99682297
80Pulmonary fibrosis (HP:0002206)1.99247593
81Gastrointestinal inflammation (HP:0004386)1.99146045
82Arterial thrombosis (HP:0004420)1.98000187
83Hemiplegia (HP:0002301)1.97281527
84Recurrent otitis media (HP:0000403)1.96519196
85Epistaxis (HP:0000421)1.96346946
86Hypochromic anemia (HP:0001931)1.96135410
87Gastrointestinal stroma tumor (HP:0100723)1.95702906
88Purpura (HP:0000979)1.92724208
89Urticaria (HP:0001025)1.92083991
90Cerebral palsy (HP:0100021)1.89922820
91Ureteral obstruction (HP:0006000)1.89871162
92Increased serum ferritin (HP:0003281)1.86818570
93Thrombophlebitis (HP:0004418)1.85265563
94Polyneuropathy (HP:0001271)1.84505290
95Gingival bleeding (HP:0000225)1.83186340
96Arthralgia (HP:0002829)1.82799653
97Abnormality of the pericardium (HP:0001697)1.80806001
98Malnutrition (HP:0004395)1.79763972
99Abnormality of male internal genitalia (HP:0000022)1.77156910
100Gingivitis (HP:0000230)1.77091298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.96883326
2KDR4.87377075
3MAP4K14.74135325
4TESK24.47232233
5ITK2.81741446
6TAOK32.56740488
7FES2.33056270
8ZAP702.18254920
9CSK2.09716970
10RIPK41.97039409
11IKBKE1.94929535
12GRK61.93736577
13TESK11.88389134
14SYK1.83826007
15LCK1.80740040
16TBK11.70425467
17TYK21.64487874
18JAK31.63296249
19BTK1.60875451
20MAP3K121.60790281
21MAP3K111.53007977
22PRKCQ1.52670401
23JAK11.44732403
24BCKDK1.43159615
25MAPKAPK31.38577522
26TLK11.37205023
27MAP3K141.31322342
28ERN11.22566464
29IKBKB1.22290321
30LYN1.19406977
31TEC1.15975082
32TNK21.14076695
33BLK1.13214603
34LIMK11.11697068
35GRK71.09792719
36FGFR41.08954328
37CSF1R1.05238102
38ADRBK21.02204209
39IRAK40.95853366
40HCK0.90532071
41MST40.89624766
42PIK3CA0.88027060
43JAK20.83370473
44MAPK110.81273363
45FYN0.79392759
46MAP2K60.76310325
47SCYL20.71531990
48CAMKK20.70825758
49KIT0.70196478
50PIM10.67805486
51DAPK10.66508739
52MUSK0.65382615
53PIK3CG0.64657833
54VRK20.63908489
55PDK10.63600776
56MYLK0.62291283
57STK100.60288094
58MAP2K20.57477847
59TYRO30.56873760
60EPHB10.53629586
61PRPF4B0.52607253
62IGF1R0.52409678
63ZAK0.51655741
64MAP3K130.49814405
65MAPKAPK20.48036853
66MARK30.47869541
67SIK30.47597336
68BMPR20.43555261
69INSR0.43281709
70ACVR1B0.41300559
71NLK0.40922294
72FGFR30.39959135
73MATK0.39393894
74CLK10.38650653
75GRK10.37859947
76MAP4K20.37485224
77CAMKK10.36802129
78PRKCH0.35836797
79MAP3K30.35347050
80VRK10.34711488
81WNK40.33922078
82EPHA30.33850265
83TGFBR20.32639084
84TAOK20.32074071
85MAP3K50.30784406
86CDK40.28624922
87PASK0.28074172
88FGR0.27575659
89OBSCN0.27040620
90MAPK120.26871546
91TRPM70.25850692
92PTK60.25546445
93MAP3K10.25318784
94ROCK10.24057987
95PRKCD0.23091999
96MAP3K70.22939298
97PDGFRB0.22431773
98LRRK20.22405016
99PRKCA0.22310809
100MAPK30.22087421

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.02779277
2Graft-versus-host disease_Homo sapiens_hsa053324.02211203
3Autoimmune thyroid disease_Homo sapiens_hsa053203.68361465
4Allograft rejection_Homo sapiens_hsa053303.54729150
5Antigen processing and presentation_Homo sapiens_hsa046123.33730055
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.19171796
7T cell receptor signaling pathway_Homo sapiens_hsa046603.16511664
8Hematopoietic cell lineage_Homo sapiens_hsa046402.70729445
9Type I diabetes mellitus_Homo sapiens_hsa049402.58884432
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36448723
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.18542953
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12467804
13Measles_Homo sapiens_hsa051622.10700407
14Proteasome_Homo sapiens_hsa030502.08957781
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.01068583
16Viral myocarditis_Homo sapiens_hsa054161.83711051
17Staphylococcus aureus infection_Homo sapiens_hsa051501.67594127
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.64574119
19Caffeine metabolism_Homo sapiens_hsa002321.59264694
20Rheumatoid arthritis_Homo sapiens_hsa053231.54494626
21Asthma_Homo sapiens_hsa053101.38562697
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36232698
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35205837
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26500727
25Leishmaniasis_Homo sapiens_hsa051401.26325744
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23130842
27Shigellosis_Homo sapiens_hsa051311.15956346
28Chemokine signaling pathway_Homo sapiens_hsa040621.15948998
29Osteoclast differentiation_Homo sapiens_hsa043801.13967062
30Salmonella infection_Homo sapiens_hsa051321.13915377
31Malaria_Homo sapiens_hsa051441.13686338
32Herpes simplex infection_Homo sapiens_hsa051681.11140633
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10131465
34Fat digestion and absorption_Homo sapiens_hsa049751.09653792
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05898249
36Retinol metabolism_Homo sapiens_hsa008301.00412163
37Jak-STAT signaling pathway_Homo sapiens_hsa046300.99949005
38Linoleic acid metabolism_Homo sapiens_hsa005910.99908225
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.98106840
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.93322792
41TNF signaling pathway_Homo sapiens_hsa046680.92535051
42Chemical carcinogenesis_Homo sapiens_hsa052040.87774494
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86582744
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83857529
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81182343
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79860240
47B cell receptor signaling pathway_Homo sapiens_hsa046620.79232829
48Pertussis_Homo sapiens_hsa051330.79210250
49Complement and coagulation cascades_Homo sapiens_hsa046100.78578973
50Influenza A_Homo sapiens_hsa051640.74937843
51Apoptosis_Homo sapiens_hsa042100.74488612
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.71992774
53Vitamin digestion and absorption_Homo sapiens_hsa049770.70534308
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69686631
55African trypanosomiasis_Homo sapiens_hsa051430.66234868
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65338702
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64244526
58Renin-angiotensin system_Homo sapiens_hsa046140.60686981
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.59777060
60Sulfur metabolism_Homo sapiens_hsa009200.58788781
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58397807
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58109144
63Prion diseases_Homo sapiens_hsa050200.55680977
64Tuberculosis_Homo sapiens_hsa051520.54379861
65Legionellosis_Homo sapiens_hsa051340.51371921
66Toxoplasmosis_Homo sapiens_hsa051450.50950405
67Oxidative phosphorylation_Homo sapiens_hsa001900.50577803
68Epstein-Barr virus infection_Homo sapiens_hsa051690.50528621
69Arachidonic acid metabolism_Homo sapiens_hsa005900.48081733
70Peroxisome_Homo sapiens_hsa041460.47933369
71Systemic lupus erythematosus_Homo sapiens_hsa053220.47600492
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.46834587
73HTLV-I infection_Homo sapiens_hsa051660.44798762
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44341330
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44113375
76Parkinsons disease_Homo sapiens_hsa050120.44015054
77Starch and sucrose metabolism_Homo sapiens_hsa005000.37987440
78Mineral absorption_Homo sapiens_hsa049780.37304755
79Phenylalanine metabolism_Homo sapiens_hsa003600.36290461
80Endocytosis_Homo sapiens_hsa041440.33531865
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33104228
82Arginine biosynthesis_Homo sapiens_hsa002200.30537522
83PPAR signaling pathway_Homo sapiens_hsa033200.28748955
84Hepatitis C_Homo sapiens_hsa051600.28035175
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.27914779
86Fatty acid degradation_Homo sapiens_hsa000710.27489477
87Viral carcinogenesis_Homo sapiens_hsa052030.26657995
88Fructose and mannose metabolism_Homo sapiens_hsa000510.23992376
89Tryptophan metabolism_Homo sapiens_hsa003800.23212221
90ABC transporters_Homo sapiens_hsa020100.21413016
91Histidine metabolism_Homo sapiens_hsa003400.21354895
92Alzheimers disease_Homo sapiens_hsa050100.20767772
93Glycerolipid metabolism_Homo sapiens_hsa005610.20635083
94Nitrogen metabolism_Homo sapiens_hsa009100.20600763
95Hepatitis B_Homo sapiens_hsa051610.18402584
96Platelet activation_Homo sapiens_hsa046110.18344838
97Bile secretion_Homo sapiens_hsa049760.17481829
98Butanoate metabolism_Homo sapiens_hsa006500.15585317
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13780828
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12496290

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