IL33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.45497879
2central nervous system myelination (GO:0022010)5.45497879
3surfactant homeostasis (GO:0043129)5.25964511
4myelin maintenance (GO:0043217)4.86622714
5negative regulation of fatty acid transport (GO:2000192)4.43799574
6chemical homeostasis within a tissue (GO:0048875)4.36900403
7mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.23227258
8blood vessel maturation (GO:0001955)4.13594024
9kidney mesenchyme development (GO:0072074)3.97795005
10metanephric mesenchyme development (GO:0072075)3.94319613
11endothelium development (GO:0003158)3.91853161
12glycine transport (GO:0015816)3.88783960
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.83465185
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.72916872
15chondrocyte proliferation (GO:0035988)3.69326135
16pattern specification involved in kidney development (GO:0061004)3.65470159
17extracellular fibril organization (GO:0043206)3.60576695
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.59763750
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.50077971
20cilium or flagellum-dependent cell motility (GO:0001539)3.45215515
21positive regulation of p38MAPK cascade (GO:1900745)3.41177429
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38551957
23atrial cardiac muscle cell action potential (GO:0086014)3.35603315
24L-amino acid import (GO:0043092)3.28431380
25hemidesmosome assembly (GO:0031581)3.22745986
26cellular potassium ion homeostasis (GO:0030007)3.20875867
27extracellular matrix assembly (GO:0085029)3.20134389
28ethanol oxidation (GO:0006069)3.17012629
29mesenchymal to epithelial transition (GO:0060231)3.16266126
30outer ear morphogenesis (GO:0042473)3.08364211
31regulation of vasculogenesis (GO:2001212)3.08015797
32regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.07984860
33endothelial cell morphogenesis (GO:0001886)3.07262004
34axonemal dynein complex assembly (GO:0070286)3.07201001
35developmental induction (GO:0031128)3.06361183
36import into cell (GO:0098657)3.05914794
37fibril organization (GO:0097435)3.05379696
38regulation of integrin-mediated signaling pathway (GO:2001044)3.04832417
39organ induction (GO:0001759)3.04488726
40negative regulation of complement activation (GO:0045916)3.02813609
41synaptic vesicle maturation (GO:0016188)3.02456768
42protein localization to endosome (GO:0036010)3.01182949
43cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98801290
44lymphangiogenesis (GO:0001946)2.98462827
45vascular endothelial growth factor signaling pathway (GO:0038084)2.97180493
46cell-cell signaling involved in cell fate commitment (GO:0045168)2.93497536
47regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.91950252
48potassium ion import (GO:0010107)2.89021189
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88952451
50regulation of transforming growth factor beta2 production (GO:0032909)2.88753091
51protein heterotrimerization (GO:0070208)2.88525627
52inner ear receptor cell differentiation (GO:0060113)2.88362412
53vitamin A metabolic process (GO:0006776)2.83408757
54cell differentiation involved in metanephros development (GO:0072202)2.83327262
55ethanol metabolic process (GO:0006067)2.82661092
56regulation of cholesterol biosynthetic process (GO:0045540)2.82546176
57metanephros development (GO:0001656)2.81622066
58cilium movement (GO:0003341)2.81465625
59diterpenoid biosynthetic process (GO:0016102)2.79371782
60glomerular filtration (GO:0003094)2.77412522
61negative regulation of protein activation cascade (GO:2000258)2.74572428
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73978459
63negative regulation of humoral immune response (GO:0002921)2.73681812
64myelination (GO:0042552)2.70649779
65oligodendrocyte differentiation (GO:0048709)2.69848391
66regulation of mesonephros development (GO:0061217)2.68205285
67regulation of glomerulus development (GO:0090192)2.67875457
68ensheathment of neurons (GO:0007272)2.67036168
69axon ensheathment (GO:0008366)2.67036168
70regulation of endothelial cell differentiation (GO:0045601)2.66772864
71myelination in peripheral nervous system (GO:0022011)2.64062548
72peripheral nervous system axon ensheathment (GO:0032292)2.64062548
73regulation of apoptotic cell clearance (GO:2000425)2.61415841
74renal filtration (GO:0097205)2.60485725
75mesodermal cell differentiation (GO:0048333)2.59832380
76regulation of p38MAPK cascade (GO:1900744)2.59624816
77branch elongation of an epithelium (GO:0060602)2.58719223
78positive regulation of osteoblast proliferation (GO:0033690)2.56859247
79sequestering of extracellular ligand from receptor (GO:0035581)2.56252763
80amino acid import (GO:0043090)2.55840992
81positive regulation of mesonephros development (GO:0061213)2.55576101
82regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.55336775
83purine nucleotide transport (GO:0015865)2.55205232
84mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55072081
85mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55072081
86cell migration involved in sprouting angiogenesis (GO:0002042)2.54823865
87gap junction assembly (GO:0016264)2.54626302
88regulation of cardiac muscle cell contraction (GO:0086004)2.53484247
89prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.52364824
90endocrine hormone secretion (GO:0060986)2.52320231
91fibroblast migration (GO:0010761)2.51690733
92positive regulation of macrophage cytokine production (GO:0060907)2.50608608
93negative regulation of response to reactive oxygen species (GO:1901032)2.50597517
94phospholipid homeostasis (GO:0055091)2.50508434
95interleukin-6-mediated signaling pathway (GO:0070102)2.50407200
96negative regulation of cardiac muscle tissue growth (GO:0055022)2.50220239
97negative regulation of heart growth (GO:0061117)2.50220239
98mechanoreceptor differentiation (GO:0042490)2.49982662
99regulation of lipoprotein metabolic process (GO:0050746)2.48075583
100metanephric epithelium development (GO:0072207)2.47456779
101regulation of glomerular filtration (GO:0003093)2.47028787
102negative regulation of chondrocyte differentiation (GO:0032331)2.46821127
103wound healing, spreading of epidermal cells (GO:0035313)2.45584455
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.44667290
105negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.43943172
106mesonephros development (GO:0001823)2.43663882
107primary alcohol catabolic process (GO:0034310)2.43609467
108amino-acid betaine metabolic process (GO:0006577)2.43410494
109lateral sprouting from an epithelium (GO:0060601)2.41445595
110heart valve formation (GO:0003188)2.41025292
111regulation of chemokine-mediated signaling pathway (GO:0070099)2.40966631
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40711433
113regulation of complement activation (GO:0030449)2.40072959
114lens fiber cell development (GO:0070307)2.39905082
115negative regulation of endothelial cell migration (GO:0010596)2.39559446
116polyol transport (GO:0015791)2.38721581
117negative regulation of protein localization to cell surface (GO:2000009)2.38683108
118locomotory exploration behavior (GO:0035641)2.37806901
119positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.37743057
120sodium-independent organic anion transport (GO:0043252)2.37469697
121lung vasculature development (GO:0060426)2.37465519
122cell adhesion mediated by integrin (GO:0033627)2.37294621
123glomerulus development (GO:0032835)2.37039420
124negative regulation of organic acid transport (GO:0032891)2.36873579
125pericardium development (GO:0060039)2.36676259
126lymph vessel development (GO:0001945)2.36340041
127apical protein localization (GO:0045176)2.35353995
128lung lobe morphogenesis (GO:0060463)2.33939217
129positive regulation of receptor recycling (GO:0001921)2.33800405
130keratan sulfate catabolic process (GO:0042340)2.33526146
131complement activation, classical pathway (GO:0006958)2.33474387
132renal absorption (GO:0070293)2.33178297
133potassium ion homeostasis (GO:0055075)2.32695235
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.31659848
135negative regulation of metanephros development (GO:0072217)2.31536328
136response to follicle-stimulating hormone (GO:0032354)2.29999696
137asymmetric protein localization (GO:0008105)2.29570979
138regulation of plasminogen activation (GO:0010755)2.29006345
139positive regulation of metanephros development (GO:0072216)2.28161224
140positive regulation of vasculogenesis (GO:2001214)2.28115807
141positive regulation of urine volume (GO:0035810)2.26354229
142one-carbon compound transport (GO:0019755)2.26350069
143cellular sodium ion homeostasis (GO:0006883)2.26204652
144smooth muscle tissue development (GO:0048745)2.25630572
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.25456541
146cellular response to sterol (GO:0036315)2.25400635
147regulation of protein activation cascade (GO:2000257)2.24968412
148negative regulation of cardiac muscle tissue development (GO:0055026)2.24831157
149mesenchymal cell proliferation (GO:0010463)2.24728213
150complement activation (GO:0006956)2.23338904
151macroautophagy (GO:0016236)2.23260364
152cranial suture morphogenesis (GO:0060363)2.22251097
153peptidyl-tyrosine autophosphorylation (GO:0038083)2.22231180
154limb bud formation (GO:0060174)2.22185642
155regulation of organ formation (GO:0003156)2.22111751
156collagen fibril organization (GO:0030199)2.21149587
157regulation of osteoblast proliferation (GO:0033688)2.20725649
158mesonephric epithelium development (GO:0072163)2.19924283
159negative regulation of smooth muscle cell migration (GO:0014912)2.19495564
160endothelial cell chemotaxis (GO:0035767)2.19175129
161cellular glucuronidation (GO:0052695)2.18880838
162axis elongation (GO:0003401)2.18793846
163membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.18491124
164enteric nervous system development (GO:0048484)2.18293724
165desmosome organization (GO:0002934)2.16178219
166regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.15932935
167regulation of actin filament-based movement (GO:1903115)2.14775238
168oligosaccharide biosynthetic process (GO:0009312)2.14603375
169branching involved in salivary gland morphogenesis (GO:0060445)2.13422798
170sodium ion export (GO:0071436)2.13347551
171positive regulation of endothelial cell differentiation (GO:0045603)2.13199504
172purine ribonucleotide transport (GO:0015868)2.13013201
173glomerular basement membrane development (GO:0032836)2.12944926
174negative regulation of blood vessel endothelial cell migration (GO:0043537)2.12795400
175proximal/distal pattern formation (GO:0009954)2.11760472
176epithelial cilium movement (GO:0003351)2.11721333
177venous blood vessel morphogenesis (GO:0048845)2.11277477
178apoptotic cell clearance (GO:0043277)2.10960502
179receptor catabolic process (GO:0032801)2.10904431
180Notch signaling involved in heart development (GO:0061314)2.10698442
181glutamate secretion (GO:0014047)2.09755614
182regulation of synaptic vesicle exocytosis (GO:2000300)2.09510155
183positive regulation of potassium ion transport (GO:0043268)2.09406335
184renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.09286087
185regulation of phospholipase A2 activity (GO:0032429)2.08287208
186mesonephric tubule development (GO:0072164)2.08100309
187retinal metabolic process (GO:0042574)2.07568148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06312123
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.77277268
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.70471966
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.38473107
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.37034851
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28427739
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14276700
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11800695
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05425010
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05425010
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.03564999
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02519097
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97917526
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95298782
15AR_21572438_ChIP-Seq_LNCaP_Human1.95164899
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89946811
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.89286210
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86613190
19EZH2_22144423_ChIP-Seq_EOC_Human1.85773574
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80819805
21DROSHA_22980978_ChIP-Seq_HELA_Human1.80193135
22* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78708305
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78134205
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78100267
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76783936
26GBX2_23144817_ChIP-Seq_PC3_Human1.67551473
27AHR_22903824_ChIP-Seq_MCF-7_Human1.61040209
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59759735
29* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58350264
30* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58350264
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58158390
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54656945
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54288750
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.48573446
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.47395045
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46671266
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45970649
38TP53_18474530_ChIP-ChIP_U2OS_Human1.45610816
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.42735690
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41574639
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41150160
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.40162612
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39076548
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.38543867
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36464177
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33089024
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.32134249
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28325831
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27657271
50SOX2_20726797_ChIP-Seq_SW620_Human1.25666383
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24140902
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23950112
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22113002
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.20824111
55CJUN_26792858_Chip-Seq_BT549_Human1.18400227
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17905795
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16627130
58* TBX20_22328084_ChIP-Seq_HEART_Mouse1.15875789
59* TBX20_22080862_ChIP-Seq_HEART_Mouse1.15875789
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15365643
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14309095
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14280146
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13485764
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13140739
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12747361
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11772808
67* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11540517
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11101198
69BRD4_25478319_ChIP-Seq_HGPS_Human1.10920845
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10895004
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.10845105
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09672200
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.09334165
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09309150
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08161869
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07827118
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.05097480
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.04409654
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04184468
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03559188
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.03262784
82* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03169945
83STAT3_23295773_ChIP-Seq_U87_Human1.01773385
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01533342
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01025519
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.00233719
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99882017
88AR_25329375_ChIP-Seq_VCAP_Human0.99607061
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99440532
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.99341562
91FOXA2_19822575_ChIP-Seq_HepG2_Human0.98671812
92P300_19829295_ChIP-Seq_ESCs_Human0.98612214
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97726272
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97671258
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97531281
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.97301689
97NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96794481
98TAF15_26573619_Chip-Seq_HEK293_Human0.96331307
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96047621
100BCAT_22108803_ChIP-Seq_LS180_Human0.95936795
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.95697351
102KLF5_25053715_ChIP-Seq_YYC3_Human0.95303007
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95070909
104* CDX2_22108803_ChIP-Seq_LS180_Human0.94917701
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94618662
106TP53_16413492_ChIP-PET_HCT116_Human0.94302953
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93907142
108* FOXO3_23340844_ChIP-Seq_DLD1_Human0.93770380
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.93721664
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93615537
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93594739
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93594702
113RXR_22108803_ChIP-Seq_LS180_Human0.93579551
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.91944709
115CLOCK_20551151_ChIP-Seq_293T_Human0.91665724
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91616401
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91517594
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91448459
119* TP63_23658742_ChIP-Seq_EP156T_Human0.90905091
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.90890511
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90342509
122* SMAD4_21799915_ChIP-Seq_A2780_Human0.89836691
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88963989
124KDM2B_26808549_Chip-Seq_K562_Human0.88720121
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88355078
126* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87568907
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86602850
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85122794
129ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84501741
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84218913
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84081230
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.83346625
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83234582
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.82061719
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82035801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog3.58008108
2MP0003279_aneurysm3.42337956
3MP0001177_atelectasis3.23909390
4MP0001958_emphysema2.88414066
5MP0003705_abnormal_hypodermis_morpholog2.70821291
6MP0010030_abnormal_orbit_morphology2.60510628
7MP0003690_abnormal_glial_cell2.51247080
8MP0001346_abnormal_lacrimal_gland2.45667793
9MP0004885_abnormal_endolymph2.42035296
10MP0000534_abnormal_ureter_morphology2.41803097
11MP0006054_spinal_hemorrhage2.39572139
12MP0005275_abnormal_skin_tensile2.33094651
13MP0000566_synostosis2.26060321
14MP0003942_abnormal_urinary_system2.25206314
15MP0000383_abnormal_hair_follicle2.13035418
16MP0000920_abnormal_myelination2.10962367
17MP0002133_abnormal_respiratory_system2.10443223
18MP0005388_respiratory_system_phenotype2.10443223
19MP0002295_abnormal_pulmonary_circulatio2.08959434
20MP0010678_abnormal_skin_adnexa2.06221769
21MP0003011_delayed_dark_adaptation1.93477763
22MP0004859_abnormal_synaptic_plasticity1.87636319
23MP0002822_catalepsy1.84165088
24MP0008438_abnormal_cutaneous_collagen1.82427088
25MP0005171_absent_coat_pigmentation1.81002280
26MP0000579_abnormal_nail_morphology1.78918001
27MP0003075_altered_response_to1.76132108
28MP0001984_abnormal_olfaction1.74353328
29MP0000767_abnormal_smooth_muscle1.72945452
30MP0009840_abnormal_foam_cell1.71656010
31MP0003950_abnormal_plasma_membrane1.68492753
32MP0005503_abnormal_tendon_morphology1.66595708
33MP0005595_abnormal_vascular_smooth1.64339881
34MP0003880_abnormal_central_pattern1.63992767
35MP0000013_abnormal_adipose_tissue1.60335064
36MP0010352_gastrointestinal_tract_polyps1.54366973
37MP0005623_abnormal_meninges_morphology1.51562768
38MP0008004_abnormal_stomach_pH1.49450662
39MP0000762_abnormal_tongue_morphology1.47808920
40MP0005164_abnormal_response_to1.47142377
41MP0002233_abnormal_nose_morphology1.46843622
42MP0003453_abnormal_keratinocyte_physiol1.43348181
43MP0001486_abnormal_startle_reflex1.42173814
44MP0010368_abnormal_lymphatic_system1.40748095
45MP0006138_congestive_heart_failure1.40022470
46MP0005394_taste/olfaction_phenotype1.39888399
47MP0005499_abnormal_olfactory_system1.39888399
48MP0000537_abnormal_urethra_morphology1.39846630
49MP0000465_gastrointestinal_hemorrhage1.38058339
50MP0002796_impaired_skin_barrier1.37826949
51MP0003115_abnormal_respiratory_system1.37750073
52MP0002282_abnormal_trachea_morphology1.37315903
53MP0004043_abnormal_pH_regulation1.34632435
54MP0001881_abnormal_mammary_gland1.34595605
55MP0004084_abnormal_cardiac_muscle1.34415629
56MP0001542_abnormal_bone_strength1.33582081
57MP0003828_pulmonary_edema1.32160058
58MP0002249_abnormal_larynx_morphology1.31772167
59MP0003329_amyloid_beta_deposits1.31502304
60MP0000467_abnormal_esophagus_morphology1.27789933
61MP0004215_abnormal_myocardial_fiber1.25386179
62MP0002254_reproductive_system_inflammat1.25315375
63MP0000751_myopathy1.24606383
64MP0003091_abnormal_cell_migration1.24563636
65MP0004484_altered_response_of1.23361582
66MP0002132_abnormal_respiratory_system1.23017409
67MP0000249_abnormal_blood_vessel1.22529026
68MP0005167_abnormal_blood-brain_barrier1.22430259
69MP0005257_abnormal_intraocular_pressure1.20423377
70MP0000343_altered_response_to1.19563598
71MP0008789_abnormal_olfactory_epithelium1.18705667
72MP0005248_abnormal_Harderian_gland1.18695401
73MP0000647_abnormal_sebaceous_gland1.17926724
74MP0003635_abnormal_synaptic_transmissio1.16722344
75MP0004272_abnormal_basement_membrane1.16449133
76MP0001879_abnormal_lymphatic_vessel1.13250615
77MP0005409_darkened_coat_color1.13022951
78MP0008569_lethality_at_weaning1.13006281
79MP0009745_abnormal_behavioral_response1.12945988
80MP0005646_abnormal_pituitary_gland1.12745321
81MP0004270_analgesia1.12526747
82MP0002272_abnormal_nervous_system1.11472718
83MP0005165_increased_susceptibility_to1.08264823
84MP0005166_decreased_susceptibility_to1.07002218
85MP0003634_abnormal_glial_cell1.06625198
86MP0009250_abnormal_appendicular_skeleto1.06025421
87MP0008775_abnormal_heart_ventricle1.04950816
88MP0002896_abnormal_bone_mineralization1.04907851
89MP0005377_hearing/vestibular/ear_phenot1.04586478
90MP0003878_abnormal_ear_physiology1.04586478
91MP0003724_increased_susceptibility_to1.02460644
92MP0002168_other_aberrant_phenotype1.02339731
93MP0002128_abnormal_blood_circulation1.01937698
94MP0002064_seizures0.99587856
95MP0000639_abnormal_adrenal_gland0.99242908
96MP0001299_abnormal_eye_distance/0.94314643
97MP0008875_abnormal_xenobiotic_pharmacok0.93141494
98MP0005385_cardiovascular_system_phenoty0.92976863
99MP0001544_abnormal_cardiovascular_syste0.92976863
100MP0001851_eye_inflammation0.92760379
101MP0002090_abnormal_vision0.91127112
102MP0005620_abnormal_muscle_contractility0.91089373
103MP0003938_abnormal_ear_development0.90880682
104MP0005023_abnormal_wound_healing0.88677533
105MP0004036_abnormal_muscle_relaxation0.85609816
106MP0003633_abnormal_nervous_system0.84786249
107MP0002063_abnormal_learning/memory/cond0.84715011
108MP0000462_abnormal_digestive_system0.84191168
109MP0002108_abnormal_muscle_morphology0.84172450
110MP0000230_abnormal_systemic_arterial0.83930928
111MP0002060_abnormal_skin_morphology0.83264442
112MP0005187_abnormal_penis_morphology0.82950638
113MP0000003_abnormal_adipose_tissue0.82112858
114MP0001614_abnormal_blood_vessel0.82098029
115MP0002098_abnormal_vibrissa_morphology0.81629267
116MP0004883_abnormal_blood_vessel0.81122197
117MP0004858_abnormal_nervous_system0.80905817
118MP0002909_abnormal_adrenal_gland0.80244974
119MP0004130_abnormal_muscle_cell0.79606352
120MP0009053_abnormal_anal_canal0.79504691
121MP0005670_abnormal_white_adipose0.78814416
122MP0003191_abnormal_cellular_cholesterol0.78261071
123MP0004134_abnormal_chest_morphology0.78115081
124MP0002972_abnormal_cardiac_muscle0.77759136
125MP0003941_abnormal_skin_development0.77555445
126MP0002998_abnormal_bone_remodeling0.76832044
127MP0000750_abnormal_muscle_regeneration0.76822899
128MP0002734_abnormal_mechanical_nocicepti0.76148331
129MP0003566_abnormal_cell_adhesion0.75560070
130MP0010771_integument_phenotype0.75512527
131MP0000955_abnormal_spinal_cord0.75347056
132MP0001919_abnormal_reproductive_system0.75079809
133MP0009384_cardiac_valve_regurgitation0.73746237
134MP0001970_abnormal_pain_threshold0.73718062
135MP0004742_abnormal_vestibular_system0.73463092
136MP0008995_early_reproductive_senescence0.73128199
137MP0005508_abnormal_skeleton_morphology0.72899654
138MP0008260_abnormal_autophagy0.72067039
139MP0002933_joint_inflammation0.71263393
140MP0003300_gastrointestinal_ulcer0.69917803
141MP0004085_abnormal_heartbeat0.69648888
142MP0010234_abnormal_vibrissa_follicle0.68837230
143MP0002332_abnormal_exercise_endurance0.68612387
144MP0003631_nervous_system_phenotype0.68400677
145MP0009780_abnormal_chondrocyte_physiolo0.67976550
146MP0000604_amyloidosis0.67928875
147MP0001175_abnormal_lung_morphology0.67353264
148MP0003045_fibrosis0.66862555
149MP0002925_abnormal_cardiovascular_devel0.66324367
150MP0001501_abnormal_sleep_pattern0.64650951
151MP0002127_abnormal_cardiovascular_syste0.63768570
152MP0000627_abnormal_mammary_gland0.63236797
153MP0001915_intracranial_hemorrhage0.63171044
154MP0002971_abnormal_brown_adipose0.60941893
155MP0005375_adipose_tissue_phenotype0.60013540
156MP0005330_cardiomyopathy0.59092524
157MP0005666_abnormal_adipose_tissue0.58063809
158MP0010329_abnormal_lipoprotein_level0.57383704

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.65391899
2Aortic dissection (HP:0002647)4.85211429
3Potter facies (HP:0002009)4.83919557
4Facial shape deformation (HP:0011334)4.83919557
5Aplasia involving bones of the upper limbs (HP:0009823)4.82575000
6Aplasia of the phalanges of the hand (HP:0009802)4.82575000
7Aplasia involving bones of the extremities (HP:0009825)4.82575000
8Aortic aneurysm (HP:0004942)4.75870516
9Vascular tortuosity (HP:0004948)4.36927998
10Arterial tortuosity (HP:0005116)4.24695841
11Interstitial pulmonary disease (HP:0006530)4.14044051
12Neurofibrillary tangles (HP:0002185)4.11103653
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.82921907
14Abnormality of cochlea (HP:0000375)3.58402678
15Complement deficiency (HP:0004431)3.56408482
16Premature rupture of membranes (HP:0001788)3.55183332
17Morphological abnormality of the inner ear (HP:0011390)3.45592574
18Rhinitis (HP:0012384)3.38986572
19Limb dystonia (HP:0002451)3.38958873
20Broad metatarsal (HP:0001783)3.37925769
21Abnormal ciliary motility (HP:0012262)3.37918029
22Onycholysis (HP:0001806)3.37812193
23Abnormal respiratory motile cilium physiology (HP:0012261)3.30805777
24Megalencephaly (HP:0001355)3.28770762
25Cerebral inclusion bodies (HP:0100314)3.11904146
26Dysphonia (HP:0001618)3.07003119
27Abnormal respiratory epithelium morphology (HP:0012253)3.03866624
28Abnormal respiratory motile cilium morphology (HP:0005938)3.03866624
29Partial duplication of thumb phalanx (HP:0009944)3.03318824
30Torticollis (HP:0000473)3.03272072
31Chronic bronchitis (HP:0004469)3.00943215
32Cerebral hypomyelination (HP:0006808)2.94960400
33Absent/shortened dynein arms (HP:0200106)2.93964281
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.93964281
35Split foot (HP:0001839)2.91397141
36Stomach cancer (HP:0012126)2.90749069
37Abnormality of complement system (HP:0005339)2.89751779
38Alacrima (HP:0000522)2.89660953
39Tetraparesis (HP:0002273)2.88518479
40Bronchomalacia (HP:0002780)2.84409957
41Alopecia of scalp (HP:0002293)2.81271502
42Partial duplication of the phalanx of hand (HP:0009999)2.81177629
43Ulnar bowing (HP:0003031)2.80133620
44Absent frontal sinuses (HP:0002688)2.77303625
45Soft skin (HP:0000977)2.75466099
46Wormian bones (HP:0002645)2.74388157
47Spondylolisthesis (HP:0003302)2.73828927
48Supranuclear gaze palsy (HP:0000605)2.72727184
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68772557
50Nephritis (HP:0000123)2.64924664
51Humeroradial synostosis (HP:0003041)2.63640198
52Synostosis involving the elbow (HP:0003938)2.63640198
53Coronal craniosynostosis (HP:0004440)2.60632457
54Overgrowth (HP:0001548)2.58306380
55Mitral stenosis (HP:0001718)2.58232592
56Pulmonary artery stenosis (HP:0004415)2.57790648
57Striae distensae (HP:0001065)2.54735429
58Abnormality of the nasal mucosa (HP:0000433)2.51691359
59Turricephaly (HP:0000262)2.51330590
60Recurrent corneal erosions (HP:0000495)2.51129527
61Axonal loss (HP:0003447)2.50422636
62Atrophic scars (HP:0001075)2.49573980
63Milia (HP:0001056)2.49309179
64Focal segmental glomerulosclerosis (HP:0000097)2.48914294
65Overriding aorta (HP:0002623)2.48373069
66Hypoplastic left heart (HP:0004383)2.47790133
67Cerebral aneurysm (HP:0004944)2.45428576
68Onion bulb formation (HP:0003383)2.43269128
69Abnormal auditory evoked potentials (HP:0006958)2.41262917
70Thickened helices (HP:0000391)2.39827586
71Abnormality of the middle phalanges of the toes (HP:0010183)2.38811279
72Atrioventricular block (HP:0001678)2.38241964
73Fragile nails (HP:0001808)2.37680909
74Bladder diverticulum (HP:0000015)2.37574686
75Glomerulosclerosis (HP:0000096)2.36957088
76Stenosis of the external auditory canal (HP:0000402)2.35441701
77Neonatal short-limb short stature (HP:0008921)2.35378097
78Mitral valve prolapse (HP:0001634)2.32357117
79Respiratory distress (HP:0002098)2.29635813
80Craniofacial dystonia (HP:0012179)2.27085101
81Arnold-Chiari malformation (HP:0002308)2.26693523
82Type 1 muscle fiber predominance (HP:0003803)2.24061838
83Short hallux (HP:0010109)2.23327971
84Increased corneal curvature (HP:0100692)2.22009494
85Keratoconus (HP:0000563)2.22009494
86Aneurysm (HP:0002617)2.21512846
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.20764717
88Osteolytic defects of the hand bones (HP:0009699)2.20764717
89Esophageal atresia (HP:0002032)2.19709915
90Right ventricular cardiomyopathy (HP:0011663)2.16638901
91Hematochezia (HP:0002573)2.15954006
92Spontaneous hematomas (HP:0007420)2.14676681
93Systemic lupus erythematosus (HP:0002725)2.14459200
94Focal dystonia (HP:0004373)2.14201459
95Shallow orbits (HP:0000586)2.12988653
96Glomerulonephritis (HP:0000099)2.11849806
97Hypoplasia of the iris (HP:0007676)2.10412227
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08696087
99Myokymia (HP:0002411)2.07733293
100Dilatation of the ascending aorta (HP:0005111)2.06978607
101Mixed hearing impairment (HP:0000410)2.05439441
102Vertebral compression fractures (HP:0002953)2.04614935
103Bifid scrotum (HP:0000048)2.03619331
104Cervical subluxation (HP:0003308)2.02438656
105Bronchiectasis (HP:0002110)2.02143612
106Segmental peripheral demyelination/remyelination (HP:0003481)2.01905251
107Abnormality of the axillary hair (HP:0100134)2.01882307
108Abnormality of secondary sexual hair (HP:0009888)2.01882307
109Conjugated hyperbilirubinemia (HP:0002908)1.99688868
110Polycythemia (HP:0001901)1.99012703
111Muscle fiber splitting (HP:0003555)1.98966414
112Pterygium (HP:0001059)1.98435190
113Nasolacrimal duct obstruction (HP:0000579)1.95370513
114Abnormality of incisor morphology (HP:0011063)1.94161587
115Aplasia/Hypoplasia of the hallux (HP:0008362)1.93958510
116Abnormality of the 2nd finger (HP:0004100)1.93835287
117Hyperkalemia (HP:0002153)1.93682272
118Ankle contracture (HP:0006466)1.93190642
119Mesangial abnormality (HP:0001966)1.92889984
120Decreased lacrimation (HP:0000633)1.91540323
121Aqueductal stenosis (HP:0002410)1.91426863
122Hypoplastic heart (HP:0001961)1.90949933
123Aortic regurgitation (HP:0001659)1.89176414
124Choreoathetosis (HP:0001266)1.88602177
125Knee flexion contracture (HP:0006380)1.88119165
126Tachypnea (HP:0002789)1.87680081
127Preauricular pit (HP:0004467)1.87148309
128Periauricular skin pits (HP:0100277)1.87148309
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.86954808
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86954808
131Bell-shaped thorax (HP:0001591)1.85894577
132Rectal prolapse (HP:0002035)1.85133137
133Conjunctival telangiectasia (HP:0000524)1.84670245
134Plantar hyperkeratosis (HP:0007556)1.84300119
135Hydroxyprolinuria (HP:0003080)1.84080070
136Abnormality of proline metabolism (HP:0010907)1.84080070
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83908763
138Hypokalemic alkalosis (HP:0001949)1.83830562
139Germ cell neoplasia (HP:0100728)1.83532975
140Occipital encephalocele (HP:0002085)1.82107926
141Ectopia lentis (HP:0001083)1.81884115
142Postural instability (HP:0002172)1.81675289
143Joint laxity (HP:0001388)1.81662050
144Follicular hyperkeratosis (HP:0007502)1.81597941
145Mitral regurgitation (HP:0001653)1.81544212
146Tubulointerstitial abnormality (HP:0001969)1.81537070
147Venous insufficiency (HP:0005293)1.80893159
148Bronchitis (HP:0012387)1.80811267
149Premature skin wrinkling (HP:0100678)1.80349566
150Peripheral hypomyelination (HP:0007182)1.79431105
151Thick nail (HP:0001805)1.79132850
152Abnormality of molar (HP:0011077)1.79053565
153Abnormality of molar morphology (HP:0011070)1.79053565
154Action tremor (HP:0002345)1.79027897
155Broad ribs (HP:0000885)1.78952035
156Tubulointerstitial fibrosis (HP:0005576)1.78254631
157Hyperactive renin-angiotensin system (HP:0000841)1.78150266
158Mildly elevated creatine phosphokinase (HP:0008180)1.77735456
159Ankle clonus (HP:0011448)1.77624237
160Visceral angiomatosis (HP:0100761)1.76985820
161Spinal rigidity (HP:0003306)1.76781978
162Aortic valve stenosis (HP:0001650)1.76727798
163Abnormality of dentin (HP:0010299)1.76621009
164Broad distal phalanx of finger (HP:0009836)1.76498772
165Abnormality of the dental root (HP:0006486)1.74816466
166Taurodontia (HP:0000679)1.74816466
167Abnormality of permanent molar morphology (HP:0011071)1.74816466
168Wide anterior fontanel (HP:0000260)1.73721220
169Chorioretinal atrophy (HP:0000533)1.72891031
170Long nose (HP:0003189)1.72714512
171Gastrointestinal atresia (HP:0002589)1.72105303
172Renal salt wasting (HP:0000127)1.71788644
173Abnormality of the salivary glands (HP:0010286)1.71553813
174Progressive sensorineural hearing impairment (HP:0000408)1.71457795
175Hypoplastic labia majora (HP:0000059)1.70984812
176Lymphangioma (HP:0100764)1.70137349
177Heart block (HP:0012722)1.68950521
178Abnormality of the frontal sinuses (HP:0002687)1.68747156
179Limited hip movement (HP:0008800)1.68310641
180Narrow nasal bridge (HP:0000446)1.68117712
181Fragile skin (HP:0001030)1.68084224
182Cardiovascular calcification (HP:0011915)1.66362326
183Paraparesis (HP:0002385)1.66132443
184Hyporeflexia of lower limbs (HP:0002600)1.65701047
185Increased variability in muscle fiber diameter (HP:0003557)1.64530545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.86292747
2FGFR24.06783527
3LMTK23.98112489
4LATS13.34546284
5PRKD32.74500924
6TRIB32.59649587
7MYLK2.48606035
8NEK62.25736596
9SGK4942.22934755
10SGK2232.22934755
11EPHA32.07373155
12MAP3K21.96646680
13STK391.94497641
14MET1.92592305
15PRPF4B1.91362496
16PDK21.89389556
17EPHA41.72329801
18TGFBR11.65603019
19ILK1.58524956
20DAPK21.57227955
21TEC1.57089114
22MAPK121.56813782
23FGFR31.55950322
24MST41.53896990
25LIMK11.53516042
26PKN11.52268346
27PRKCH1.50528777
28WNK11.49945865
29NLK1.48509645
30MAPKAPK51.45905067
31EPHA21.42667233
32FRK1.34753273
33PIK3CG1.32510745
34NTRK11.28050740
35PRKG21.27480447
36FER1.23892432
37SGK31.22827439
38CAMK2B1.22431680
39STK38L1.22375680
40MAP3K31.21605498
41LRRK21.21540263
42OXSR11.20105510
43ROCK21.17016192
44CAMK2G1.14101568
45SIK11.13473258
46SGK21.12858280
47MAP4K21.11532926
48AKT31.10882823
49CSNK1A1L1.10462019
50STK31.07954165
51MST1R1.07772129
52PKN21.05538318
53BCR1.05269080
54BMX1.04661989
55PHKG21.03421827
56PHKG11.03421827
57PRKD11.03187376
58MOS1.02730571
59TTN0.99828704
60PAK60.99081141
61FLT30.97338181
62UHMK10.97243662
63DMPK0.95910922
64CAMK2D0.94775111
65PTK60.94044468
66KSR20.92859239
67MAP3K90.92636154
68FGFR10.91488308
69ERBB30.90243860
70PRKCE0.89726883
71PDPK10.89098634
72CSNK1G20.88034240
73NTRK30.87770844
74WNK40.87581496
75TESK10.86921519
76EPHB10.86609203
77GRK50.82950343
78PINK10.81155213
79JAK10.80864668
80DDR20.80048684
81MAPKAPK30.78732073
82TYRO30.78096971
83PDGFRA0.77734999
84CSNK1G30.76976477
85TRPM70.76176961
86GRK10.75144676
87MAP3K60.74585792
88PDGFRB0.74526793
89MAP3K70.73636841
90IGF1R0.72585216
91PAK30.72105408
92CDK50.69058207
93PIK3CA0.67863147
94DAPK30.66590974
95PRKAA20.64576477
96CASK0.64515076
97ROCK10.63056303
98PAK20.62436598
99PNCK0.62352729
100ERBB20.61902240
101MAP2K10.60576617
102PDK10.58453207
103STK380.58248979
104BMPR20.58036593
105FGFR40.57695243
106GSK3A0.57108811
107ERN10.56860124
108CAMK2A0.55157551
109CDC42BPA0.54462688
110BMPR1B0.54229150
111ADRBK10.53231357
112CSNK1G10.52937854
113IRAK10.52561770
114PTK20.51133001
115ZAP700.50836021
116TGFBR20.50825119
117MARK10.50458831
118RET0.49603740
119STK100.49523258
120NEK90.48635995
121CDK30.47911726
122PRKCQ0.47551051
123ERBB40.46452018
124NTRK20.46361977
125EPHB20.46165833
126KIT0.46095480
127SRC0.46057086
128KDR0.45013563
129PTK2B0.43866661
130PRKCZ0.43858629
131CAMKK10.43742311
132RPS6KA20.43497115
133TAOK20.43388259
134OBSCN0.43339283
135YES10.43292063
136STK240.43095864
137MAP3K10.43073871
138SGK10.42121257
139MAPK70.42113417
140MARK20.41012845
141RIPK10.39868958
142PLK20.39603785
143LATS20.39088442
144MAP2K20.38686037
145MAPK150.38395468
146MAP3K120.37910405
147MINK10.37632442
148INSR0.37089039

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.35230723
2Complement and coagulation cascades_Homo sapiens_hsa046102.39088312
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17377470
4Sulfur metabolism_Homo sapiens_hsa009202.14104612
5Mineral absorption_Homo sapiens_hsa049781.80843872
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71161333
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65011390
8Malaria_Homo sapiens_hsa051441.59745908
9Phenylalanine metabolism_Homo sapiens_hsa003601.55516093
10Fatty acid biosynthesis_Homo sapiens_hsa000611.54891302
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54208818
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51204877
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46725696
14Circadian rhythm_Homo sapiens_hsa047101.40951388
15Gastric acid secretion_Homo sapiens_hsa049711.40661089
16Linoleic acid metabolism_Homo sapiens_hsa005911.40416016
17Chemical carcinogenesis_Homo sapiens_hsa052041.39309414
18Tyrosine metabolism_Homo sapiens_hsa003501.37744769
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.37396539
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33837653
21beta-Alanine metabolism_Homo sapiens_hsa004101.31476614
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30970474
23Protein digestion and absorption_Homo sapiens_hsa049741.29461774
24Olfactory transduction_Homo sapiens_hsa047401.23175740
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22796298
26Vitamin B6 metabolism_Homo sapiens_hsa007501.21656438
27GABAergic synapse_Homo sapiens_hsa047271.20267889
28Tight junction_Homo sapiens_hsa045301.19696696
29Synaptic vesicle cycle_Homo sapiens_hsa047211.17806034
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17565679
31Pertussis_Homo sapiens_hsa051331.16606724
32Arachidonic acid metabolism_Homo sapiens_hsa005901.14638599
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12049376
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11587470
35Dorso-ventral axis formation_Homo sapiens_hsa043201.09925506
36Cocaine addiction_Homo sapiens_hsa050301.09469931
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08711536
38Retinol metabolism_Homo sapiens_hsa008301.07801602
39Fatty acid elongation_Homo sapiens_hsa000621.07414583
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05313369
41ECM-receptor interaction_Homo sapiens_hsa045121.04490909
42Axon guidance_Homo sapiens_hsa043601.04479038
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04008260
44Glycerolipid metabolism_Homo sapiens_hsa005610.98342644
45Salivary secretion_Homo sapiens_hsa049700.97063420
46Hippo signaling pathway_Homo sapiens_hsa043900.95886959
47Renin secretion_Homo sapiens_hsa049240.94001216
48Arginine biosynthesis_Homo sapiens_hsa002200.93631728
49Amphetamine addiction_Homo sapiens_hsa050310.91325263
50Morphine addiction_Homo sapiens_hsa050320.89064101
51Bile secretion_Homo sapiens_hsa049760.88999191
52Glutamatergic synapse_Homo sapiens_hsa047240.87317599
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86733212
54Vibrio cholerae infection_Homo sapiens_hsa051100.85826430
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85162209
56Staphylococcus aureus infection_Homo sapiens_hsa051500.84049556
57Gap junction_Homo sapiens_hsa045400.82752333
58Caffeine metabolism_Homo sapiens_hsa002320.82355467
59Circadian entrainment_Homo sapiens_hsa047130.82205453
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.81155496
61Fat digestion and absorption_Homo sapiens_hsa049750.80428923
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.80388385
63TGF-beta signaling pathway_Homo sapiens_hsa043500.80340300
64Melanoma_Homo sapiens_hsa052180.79609722
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79008846
66Fatty acid metabolism_Homo sapiens_hsa012120.78087637
67Rap1 signaling pathway_Homo sapiens_hsa040150.77189892
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76260236
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76211111
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75698790
71Melanogenesis_Homo sapiens_hsa049160.74682926
72Cholinergic synapse_Homo sapiens_hsa047250.74399493
73Starch and sucrose metabolism_Homo sapiens_hsa005000.73959422
74ErbB signaling pathway_Homo sapiens_hsa040120.72533749
75Amoebiasis_Homo sapiens_hsa051460.72416106
76Focal adhesion_Homo sapiens_hsa045100.72362999
77Bladder cancer_Homo sapiens_hsa052190.72174496
78Proteoglycans in cancer_Homo sapiens_hsa052050.70735973
79Taste transduction_Homo sapiens_hsa047420.70570508
80Tryptophan metabolism_Homo sapiens_hsa003800.69320623
81cAMP signaling pathway_Homo sapiens_hsa040240.67960033
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67653173
83Ether lipid metabolism_Homo sapiens_hsa005650.67626767
84Glutathione metabolism_Homo sapiens_hsa004800.67398252
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67052715
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66456880
87Histidine metabolism_Homo sapiens_hsa003400.66013792
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64175503
89Endometrial cancer_Homo sapiens_hsa052130.63961873
90Nicotine addiction_Homo sapiens_hsa050330.62678374
91Arginine and proline metabolism_Homo sapiens_hsa003300.62645044
92Dilated cardiomyopathy_Homo sapiens_hsa054140.62637505
93Glioma_Homo sapiens_hsa052140.61932624
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60568938
95Long-term potentiation_Homo sapiens_hsa047200.60268615
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60242543
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60169972
98Lysosome_Homo sapiens_hsa041420.59180985
99Small cell lung cancer_Homo sapiens_hsa052220.59084750
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58788811
101Adherens junction_Homo sapiens_hsa045200.57743285
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57583190
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57370346
104Dopaminergic synapse_Homo sapiens_hsa047280.57116170
105Thyroid cancer_Homo sapiens_hsa052160.56515224
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.55128791
107Insulin secretion_Homo sapiens_hsa049110.54650007
108ABC transporters_Homo sapiens_hsa020100.54390207
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54227350
110Choline metabolism in cancer_Homo sapiens_hsa052310.54144119
111Platelet activation_Homo sapiens_hsa046110.54008864
112Fatty acid degradation_Homo sapiens_hsa000710.53715988
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52833220
114GnRH signaling pathway_Homo sapiens_hsa049120.52400209
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51579245
116Ras signaling pathway_Homo sapiens_hsa040140.51329549
117Thyroid hormone synthesis_Homo sapiens_hsa049180.50682772
118Collecting duct acid secretion_Homo sapiens_hsa049660.50663275
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.50550342
120Prion diseases_Homo sapiens_hsa050200.50512546
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.50431627
122Peroxisome_Homo sapiens_hsa041460.50394602
123Pathways in cancer_Homo sapiens_hsa052000.49826873
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49717697
125PPAR signaling pathway_Homo sapiens_hsa033200.49349685
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48771375
127Ovarian steroidogenesis_Homo sapiens_hsa049130.48721715
128Phagosome_Homo sapiens_hsa041450.48575810
129African trypanosomiasis_Homo sapiens_hsa051430.48540186
130Long-term depression_Homo sapiens_hsa047300.48505168
131Estrogen signaling pathway_Homo sapiens_hsa049150.48267359
132Renal cell carcinoma_Homo sapiens_hsa052110.47578106
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46651464
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.46192055
135Pancreatic secretion_Homo sapiens_hsa049720.45695565
136Serotonergic synapse_Homo sapiens_hsa047260.45012433
137Folate biosynthesis_Homo sapiens_hsa007900.44656716
138Basal cell carcinoma_Homo sapiens_hsa052170.44606218
139Phototransduction_Homo sapiens_hsa047440.44062872
140TNF signaling pathway_Homo sapiens_hsa046680.43795631
141Insulin resistance_Homo sapiens_hsa049310.40108910
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39379887
143Sphingolipid metabolism_Homo sapiens_hsa006000.37102033

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