IL34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.84088087
2establishment of skin barrier (GO:0061436)5.79187862
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72386818
4synaptic vesicle maturation (GO:0016188)5.71957803
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.33342852
6vocalization behavior (GO:0071625)5.24133462
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.20757748
8glutamate secretion (GO:0014047)5.20749537
9synaptic vesicle exocytosis (GO:0016079)5.17090346
10regulation of water loss via skin (GO:0033561)5.11969178
11locomotory exploration behavior (GO:0035641)5.10680228
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98953123
13regulation of glutamate receptor signaling pathway (GO:1900449)4.80459522
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71460329
15regulation of synaptic vesicle exocytosis (GO:2000300)4.64265018
16keratinization (GO:0031424)4.50249525
17neuronal action potential propagation (GO:0019227)4.41941911
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.25893550
19regulation of neuronal synaptic plasticity (GO:0048168)4.24265354
20regulation of synaptic vesicle transport (GO:1902803)4.19229602
21neurotransmitter secretion (GO:0007269)4.14290522
22protein localization to synapse (GO:0035418)4.10973553
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.06149247
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.03907265
25neurotransmitter-gated ion channel clustering (GO:0072578)3.89467354
26proline transport (GO:0015824)3.88336175
27regulation of synapse structural plasticity (GO:0051823)3.88157671
28synaptic transmission, glutamatergic (GO:0035249)3.84322152
29layer formation in cerebral cortex (GO:0021819)3.82425684
30exploration behavior (GO:0035640)3.79172535
31multicellular organismal water homeostasis (GO:0050891)3.76553394
32neuron-neuron synaptic transmission (GO:0007270)3.68221649
33regulation of dendritic spine morphogenesis (GO:0061001)3.63910490
34positive regulation of membrane potential (GO:0045838)3.58081345
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57513366
36glutamate receptor signaling pathway (GO:0007215)3.56729084
37dendritic spine morphogenesis (GO:0060997)3.54308392
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53235780
39cellular potassium ion homeostasis (GO:0030007)3.52985996
40regulation of synaptic plasticity (GO:0048167)3.51542363
41long-term synaptic potentiation (GO:0060291)3.45390837
42activation of protein kinase A activity (GO:0034199)3.43899169
43long-term memory (GO:0007616)3.43592734
44positive regulation of neurotransmitter transport (GO:0051590)3.41874601
45sodium ion export (GO:0071436)3.41822763
46neuron cell-cell adhesion (GO:0007158)3.41586369
47water homeostasis (GO:0030104)3.40970565
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.33220196
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31825328
50G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31691136
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.29808022
52positive regulation of pseudopodium assembly (GO:0031274)3.29449549
53positive regulation of neurotransmitter secretion (GO:0001956)3.28222103
54regulation of postsynaptic membrane potential (GO:0060078)3.27858066
55regulation of guanylate cyclase activity (GO:0031282)3.27128765
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26083515
57neurotransmitter transport (GO:0006836)3.24592440
58adhesion of symbiont to host cell (GO:0044650)3.24028200
59virion attachment to host cell (GO:0019062)3.24028200
60positive regulation of vesicle fusion (GO:0031340)3.23083951
61regulation of vesicle fusion (GO:0031338)3.21414259
62gamma-aminobutyric acid transport (GO:0015812)3.20501495
63neuromuscular process controlling balance (GO:0050885)3.16897650
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.16465755
65regulation of clathrin-mediated endocytosis (GO:2000369)3.16424895
66cell communication involved in cardiac conduction (GO:0086065)3.14003602
67positive regulation of synapse maturation (GO:0090129)3.10927962
68neuromuscular process controlling posture (GO:0050884)3.09266766
69regulation of neurotransmitter levels (GO:0001505)3.05331689
70regulation of neurotransmitter secretion (GO:0046928)3.04922813
71positive regulation of guanylate cyclase activity (GO:0031284)3.04412642
72regulation of pseudopodium assembly (GO:0031272)3.03289308
73L-amino acid import (GO:0043092)3.03272197
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03156624
75regulation of dendritic spine development (GO:0060998)3.01637065
76glycine transport (GO:0015816)3.01018414
77positive regulation of synaptic transmission (GO:0050806)2.99683295
78regulation of synapse maturation (GO:0090128)2.98579367
79negative regulation of hormone metabolic process (GO:0032351)2.98326812
80negative regulation of hormone biosynthetic process (GO:0032353)2.98326812
81dendritic spine organization (GO:0097061)2.97368021
82amino acid import (GO:0043090)2.97298777
83regulation of neurotransmitter transport (GO:0051588)2.95597349
84endothelial cell chemotaxis (GO:0035767)2.95569339
85synaptic vesicle endocytosis (GO:0048488)2.93577756
86postsynaptic membrane organization (GO:0001941)2.92059942
87behavioral defense response (GO:0002209)2.90047204
88behavioral fear response (GO:0001662)2.90047204
89regulation of glutamate secretion (GO:0014048)2.90017956
90cell-cell junction maintenance (GO:0045217)2.89758183
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89544767
92negative regulation of amino acid transport (GO:0051956)2.89444308
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89175980
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89175980
95regulation of female receptivity (GO:0045924)2.89162328
96regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88422831
97cerebellar granule cell differentiation (GO:0021707)2.87630078
98behavioral response to cocaine (GO:0048148)2.86748584
99prepulse inhibition (GO:0060134)2.86300032
100negative regulation of dendrite morphogenesis (GO:0050774)2.82731594
101molting cycle (GO:0042303)2.82378914
102hair cycle (GO:0042633)2.82378914
103adhesion of symbiont to host (GO:0044406)2.82348214
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82091980
105auditory behavior (GO:0031223)2.81484178
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80436636
107gamma-aminobutyric acid signaling pathway (GO:0007214)2.79234141
108regulation of synaptic transmission (GO:0050804)2.79163146
109chemosensory behavior (GO:0007635)2.78887277
110membrane depolarization (GO:0051899)2.78373648
111long term synaptic depression (GO:0060292)2.77910585
112regulation of sodium ion transmembrane transporter activity (GO:2000649)2.76969506
113regulation of voltage-gated calcium channel activity (GO:1901385)2.75545105
114synaptic transmission (GO:0007268)2.73847608
115neuromuscular process (GO:0050905)2.72793312
116response to auditory stimulus (GO:0010996)2.72528882
117cGMP-mediated signaling (GO:0019934)2.72355406
118membrane hyperpolarization (GO:0060081)2.71940662
119striatum development (GO:0021756)2.71918549
120response to dietary excess (GO:0002021)2.71575535
121negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71418765
122cell volume homeostasis (GO:0006884)2.71283462
123regulation of neurotransmitter uptake (GO:0051580)2.71159180
124neuron recognition (GO:0008038)2.67525926
125cerebellar Purkinje cell differentiation (GO:0021702)2.65731521
126synaptic transmission, dopaminergic (GO:0001963)2.65282110
127learning (GO:0007612)2.64804177
128regulation of G0 to G1 transition (GO:0070316)2.63296186
129adenosine receptor signaling pathway (GO:0001973)2.62623598
130adenine nucleotide transport (GO:0051503)2.62061570
131peptide cross-linking (GO:0018149)2.61858275
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59730420
133semaphorin-plexin signaling pathway (GO:0071526)2.57044448
134negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.56582561
135keratinocyte proliferation (GO:0043616)2.54960258
136positive regulation of male gonad development (GO:2000020)2.54454978
137regulation of ARF protein signal transduction (GO:0032012)2.54313758
138positive regulation of dendritic spine development (GO:0060999)2.54277268
139cell communication by electrical coupling (GO:0010644)2.52334159
140receptor recycling (GO:0001881)2.52122761
141regulation of transforming growth factor beta1 production (GO:0032908)2.51101298
142intermediate filament organization (GO:0045109)2.50134116
143cardiac conduction (GO:0061337)2.47178412
144peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.46058237
145regulation of cGMP biosynthetic process (GO:0030826)2.42357438
146regulation of oxidative phosphorylation (GO:0002082)2.41343593
147complement activation, classical pathway (GO:0006958)2.41246785
148triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.37609189
149cellular sodium ion homeostasis (GO:0006883)2.37594944
150regulation of heart rate by cardiac conduction (GO:0086091)2.37025473
151GDP-mannose metabolic process (GO:0019673)2.36759905
152negative regulation of catenin import into nucleus (GO:0035414)2.36024483
153ventricular cardiac muscle cell action potential (GO:0086005)2.35644798
154cell migration in hindbrain (GO:0021535)2.35347546
155chondroitin sulfate catabolic process (GO:0030207)2.34637698
156autophagic vacuole assembly (GO:0000045)2.33557196
157positive regulation of protein sumoylation (GO:0033235)2.32323701
158membrane tubulation (GO:0097320)2.30541303
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.29208197
160negative regulation of keratinocyte proliferation (GO:0010839)2.27639906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35560280
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99429799
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95933229
4LXR_22292898_ChIP-Seq_THP-1_Human2.83753809
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73355916
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71605279
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71491553
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71491553
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.64322768
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63774764
11GBX2_23144817_ChIP-Seq_PC3_Human2.62092377
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54611176
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54100506
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48695935
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45616243
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45365342
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38692816
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.24024686
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.22021913
20DROSHA_22980978_ChIP-Seq_HELA_Human2.19707659
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.16290410
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14275234
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10968112
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08460624
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.07342965
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.06648771
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.95714319
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94241782
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94048998
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.91949082
31RACK7_27058665_Chip-Seq_MCF-7_Human1.91845821
32P68_20966046_ChIP-Seq_HELA_Human1.88759353
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.85603907
34AR_21572438_ChIP-Seq_LNCaP_Human1.83435979
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69418377
36* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66970334
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64565194
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.63148984
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.60047062
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.58048822
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56219848
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55296177
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.54722387
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50094318
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.49965279
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48401101
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48399422
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46026973
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45232122
50* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44432465
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44191257
52BCOR_27268052_Chip-Seq_Bcells_Human1.43479122
53ZNF263_19887448_ChIP-Seq_K562_Human1.41608850
54SA1_27219007_Chip-Seq_Bcells_Human1.41291753
55* CTCF_20526341_ChIP-Seq_ESCs_Human1.39748766
56* TP63_22573176_ChIP-Seq_HFKS_Human1.39116871
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38444493
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36444869
59KDM2B_26808549_Chip-Seq_K562_Human1.35990380
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32354928
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31729126
62SMAD4_21799915_ChIP-Seq_A2780_Human1.31136812
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31110335
64CREB1_26743006_Chip-Seq_LNCaP_Human1.30628765
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29807586
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29802638
67KDM2B_26808549_Chip-Seq_DND41_Human1.28761541
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28523120
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.27892432
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27414378
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27038768
72BCL6_27268052_Chip-Seq_Bcells_Human1.26595761
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.26096205
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22854968
75JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21512226
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20741105
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.20386185
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18107037
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18027014
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17500471
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.17411394
82AHR_22903824_ChIP-Seq_MCF-7_Human1.15585849
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14942796
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.14412290
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13278117
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.12850324
87E2F1_20622854_ChIP-Seq_HELA_Human1.12343206
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11699179
89RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11633308
90* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11444289
91OCT4_19829295_ChIP-Seq_ESCs_Human1.10746189
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10124523
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09751760
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.09597796
95TAF15_26573619_Chip-Seq_HEK293_Human1.08997776
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07254528
97PHF8_20622854_ChIP-Seq_HELA_Human1.07144720
98SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06143490
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06069700
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05484330
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.03408083
102AR_19668381_ChIP-Seq_PC3_Human1.03289366
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.02926610
104VDR_21846776_ChIP-Seq_THP-1_Human1.02764040
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02431595
106ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02333009
107RXR_22108803_ChIP-Seq_LS180_Human1.02006842
108AR_25329375_ChIP-Seq_VCAP_Human1.01861823
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01625782
110CTCF_27219007_Chip-Seq_Bcells_Human1.00405583
111KLF4_19829295_ChIP-Seq_ESCs_Human0.99879166
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98936770
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97080688
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.97039339
115TCF7_22412390_ChIP-Seq_EML_Mouse0.96362150
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96341521
117SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96116931
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.94941670
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94709169
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94705113
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.94229771
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94225400
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.94208871
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93703839
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93641241
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92968543
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.92578990
128STAT3_23295773_ChIP-Seq_U87_Human0.90803550
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.89759333
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.88877077
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87412771
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87236529
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87219485
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86680794
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84413224
136SMC4_20622854_ChIP-Seq_HELA_Human0.83976455
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83949598
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83505313
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82796194
140CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82678760
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82132630
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81492312
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81112025
144KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80453118
145GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78818798
146P300_19829295_ChIP-Seq_ESCs_Human0.78389270
147RNF2_27304074_Chip-Seq_NSC_Mouse0.78114795
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77895723
149TP53_16413492_ChIP-PET_HCT116_Human0.77772780
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.77326221
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76391940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.73789734
2MP0003880_abnormal_central_pattern4.15925287
3MP0003635_abnormal_synaptic_transmissio4.03476684
4MP0009379_abnormal_foot_pigmentation3.70080561
5MP0004270_analgesia3.57483104
6MP0002822_catalepsy3.39380180
7MP0009745_abnormal_behavioral_response3.25346725
8MP0002063_abnormal_learning/memory/cond3.22121254
9MP0002064_seizures3.00394121
10MP0001968_abnormal_touch/_nociception2.88421506
11MP0009046_muscle_twitch2.87319845
12MP0002572_abnormal_emotion/affect_behav2.61115699
13MP0010234_abnormal_vibrissa_follicle2.49828705
14MP0000566_synostosis2.45749748
15MP0002272_abnormal_nervous_system2.39243743
16MP0002736_abnormal_nociception_after2.37039471
17MP0002734_abnormal_mechanical_nocicepti2.35543101
18MP0001501_abnormal_sleep_pattern2.33814096
19MP0004858_abnormal_nervous_system2.26999705
20MP0001486_abnormal_startle_reflex2.20979874
21MP0009780_abnormal_chondrocyte_physiolo2.10889143
22MP0003329_amyloid_beta_deposits1.95435086
23MP0000579_abnormal_nail_morphology1.93262940
24MP0001958_emphysema1.87928034
25MP0003453_abnormal_keratinocyte_physiol1.86144101
26MP0002098_abnormal_vibrissa_morphology1.84886088
27MP0005409_darkened_coat_color1.84348621
28MP0001188_hyperpigmentation1.79721744
29MP0004381_abnormal_hair_follicle1.77657679
30MP0001440_abnormal_grooming_behavior1.74988036
31MP0002796_impaired_skin_barrier1.74176006
32MP0005171_absent_coat_pigmentation1.73610696
33MP0002909_abnormal_adrenal_gland1.73132914
34MP0008260_abnormal_autophagy1.72740174
35MP0001970_abnormal_pain_threshold1.72432185
36MP0002733_abnormal_thermal_nociception1.71937325
37MP0003879_abnormal_hair_cell1.67300551
38MP0008961_abnormal_basal_metabolism1.60587813
39MP0008569_lethality_at_weaning1.60505884
40MP0000751_myopathy1.60452457
41MP0002735_abnormal_chemical_nociception1.59085449
42MP0001986_abnormal_taste_sensitivity1.53790754
43MP0002067_abnormal_sensory_capabilities1.51845159
44MP0003787_abnormal_imprinting1.51530287
45MP0003183_abnormal_peptide_metabolism1.51358486
46MP0001348_abnormal_lacrimal_gland1.51252180
47MP0000013_abnormal_adipose_tissue1.48677872
48MP0004811_abnormal_neuron_physiology1.47883309
49MP0005451_abnormal_body_composition1.45443310
50MP0005423_abnormal_somatic_nervous1.45049555
51MP0005167_abnormal_blood-brain_barrier1.40713085
52MP0005646_abnormal_pituitary_gland1.38789491
53MP0005275_abnormal_skin_tensile1.35858238
54MP0005377_hearing/vestibular/ear_phenot1.35286696
55MP0003878_abnormal_ear_physiology1.35286696
56MP0002557_abnormal_social/conspecific_i1.34713268
57MP0004924_abnormal_behavior1.30885476
58MP0005386_behavior/neurological_phenoty1.30885476
59MP0003075_altered_response_to1.30294726
60MP0002184_abnormal_innervation1.25541427
61MP0004019_abnormal_vitamin_homeostasis1.24944447
62MP0009840_abnormal_foam_cell1.22866759
63MP0002066_abnormal_motor_capabilities/c1.21637843
64MP0000467_abnormal_esophagus_morphology1.20194482
65MP0003279_aneurysm1.19271588
66MP0000377_abnormal_hair_follicle1.17633945
67MP0003633_abnormal_nervous_system1.17558086
68MP0000955_abnormal_spinal_cord1.17341971
69MP0002837_dystrophic_cardiac_calcinosis1.16683424
70MP0008874_decreased_physiological_sensi1.16193741
71MP0002060_abnormal_skin_morphology1.14366112
72MP0001177_atelectasis1.13522652
73MP0001529_abnormal_vocalization1.10565970
74MP0005058_abnormal_lysosome_morphology1.09533112
75MP0008872_abnormal_physiological_respon1.08899057
76MP0001216_abnormal_epidermal_layer1.07005956
77MP0001984_abnormal_olfaction1.06837604
78MP0002882_abnormal_neuron_morphology1.06787811
79MP0004885_abnormal_endolymph1.04916176
80MP0000778_abnormal_nervous_system1.03290518
81MP0005330_cardiomyopathy1.03056548
82MP0003646_muscle_fatigue1.02818262
83MP0004947_skin_inflammation1.02626395
84MP0005623_abnormal_meninges_morphology1.02105272
85MP0003191_abnormal_cellular_cholesterol0.99687070
86MP0003283_abnormal_digestive_organ0.99500812
87MP0003631_nervous_system_phenotype0.99189618
88MP0000639_abnormal_adrenal_gland0.98235255
89MP0006138_congestive_heart_failure0.97692189
90MP0005174_abnormal_tail_pigmentation0.94052174
91MP0005503_abnormal_tendon_morphology0.93789360
92MP0004484_altered_response_of0.92787526
93MP0004085_abnormal_heartbeat0.92611665
94MP0004043_abnormal_pH_regulation0.92344376
95MP0000647_abnormal_sebaceous_gland0.91979135
96MP0002069_abnormal_eating/drinking_beha0.91218272
97MP0008438_abnormal_cutaneous_collagen0.87238198
98MP0004782_abnormal_surfactant_physiolog0.87213646
99MP0001346_abnormal_lacrimal_gland0.86723337
100MP0001849_ear_inflammation0.86028639
101MP0005257_abnormal_intraocular_pressure0.83385246
102MP0004215_abnormal_myocardial_fiber0.83199315
103MP0001765_abnormal_ion_homeostasis0.82608514
104MP0010771_integument_phenotype0.82471348
105MP0000383_abnormal_hair_follicle0.81894371
106MP0009384_cardiac_valve_regurgitation0.81783181
107MP0001502_abnormal_circadian_rhythm0.81208744
108MP0001905_abnormal_dopamine_level0.80594848
109MP0002249_abnormal_larynx_morphology0.80556154
110MP0000462_abnormal_digestive_system0.80178523
111MP0010030_abnormal_orbit_morphology0.79770930
112MP0002254_reproductive_system_inflammat0.79364975
113MP0005535_abnormal_body_temperature0.77604114
114MP0006276_abnormal_autonomic_nervous0.77480695
115MP0000920_abnormal_myelination0.76337951
116MP0002152_abnormal_brain_morphology0.76051044
117MP0009931_abnormal_skin_appearance0.74263128
118MP0004130_abnormal_muscle_cell0.73588928
119MP0003566_abnormal_cell_adhesion0.73388063
120MP0004185_abnormal_adipocyte_glucose0.73350794
121MP0003638_abnormal_response/metabolism_0.73075653
122MP0004233_abnormal_muscle_weight0.70752992
123MP0005620_abnormal_muscle_contractility0.70612106
124MP0000762_abnormal_tongue_morphology0.70552920
125MP0004142_abnormal_muscle_tone0.70416258
126MP0010368_abnormal_lymphatic_system0.69211710
127MP0010678_abnormal_skin_adnexa0.68703898
128MP0002653_abnormal_ependyma_morphology0.68492058
129MP0002876_abnormal_thyroid_physiology0.67681167
130MP0003122_maternal_imprinting0.67426283
131MP0002332_abnormal_exercise_endurance0.67371943
132MP0004272_abnormal_basement_membrane0.66645574
133MP0005023_abnormal_wound_healing0.66577847
134MP0008004_abnormal_stomach_pH0.66546862
135MP0003632_abnormal_nervous_system0.65761042
136MP0010386_abnormal_urinary_bladder0.65660568
137MP0001664_abnormal_digestion0.65277194
138MP0002090_abnormal_vision0.65177542
139MP0000604_amyloidosis0.65107404
140MP0003634_abnormal_glial_cell0.63954495
141MP0000367_abnormal_coat/_hair0.63948548
142MP0005501_abnormal_skin_physiology0.62894967
143MP0005394_taste/olfaction_phenotype0.62622492
144MP0005499_abnormal_olfactory_system0.62622492
145MP0000427_abnormal_hair_cycle0.61452923
146MP0005365_abnormal_bile_salt0.61012984
147MP0003690_abnormal_glial_cell0.60099579
148MP0004036_abnormal_muscle_relaxation0.60051771
149MP0003137_abnormal_impulse_conducting0.59971619
150MP0004145_abnormal_muscle_electrophysio0.59414843
151MP0005165_increased_susceptibility_to0.57981793
152MP0000747_muscle_weakness0.57298594
153MP0003941_abnormal_skin_development0.56121530
154MP0003705_abnormal_hypodermis_morpholog0.55997683

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.21962812
2Focal motor seizures (HP:0011153)7.11483770
3Focal seizures (HP:0007359)5.24527330
4Pili torti (HP:0003777)4.45716738
5Atonic seizures (HP:0010819)4.41091098
6Visual hallucinations (HP:0002367)4.20711142
7Epileptic encephalopathy (HP:0200134)4.16848016
8Right ventricular cardiomyopathy (HP:0011663)4.06976779
9Febrile seizures (HP:0002373)3.84374332
10Systemic lupus erythematosus (HP:0002725)3.78290440
11Absence seizures (HP:0002121)3.53017495
12Generalized tonic-clonic seizures (HP:0002069)3.50228088
13Woolly hair (HP:0002224)3.45365970
14Action tremor (HP:0002345)3.34772349
15Impaired vibration sensation in the lower limbs (HP:0002166)3.27199721
16Dialeptic seizures (HP:0011146)3.23574904
17Amblyopia (HP:0000646)3.21769704
18Abnormality of the lower motor neuron (HP:0002366)3.17871178
19Abnormal eating behavior (HP:0100738)3.08265288
20Hyperventilation (HP:0002883)3.06359516
21Akinesia (HP:0002304)3.00572438
22Abnormality of complement system (HP:0005339)2.97473788
23Progressive cerebellar ataxia (HP:0002073)2.95425443
24Increased IgE level (HP:0003212)2.95087862
25Turricephaly (HP:0000262)2.91965989
26Torticollis (HP:0000473)2.91275110
27Abnormal hair laboratory examination (HP:0003328)2.89466860
28Dysdiadochokinesis (HP:0002075)2.84803278
29Ankle clonus (HP:0011448)2.82902144
30Palmoplantar hyperkeratosis (HP:0000972)2.79742968
31Poor eye contact (HP:0000817)2.77379424
32Ventricular fibrillation (HP:0001663)2.75740004
33Depression (HP:0000716)2.74175726
34Resting tremor (HP:0002322)2.73216701
35Cerebral hypomyelination (HP:0006808)2.73083584
36Focal dystonia (HP:0004373)2.70816422
37Broad-based gait (HP:0002136)2.70765740
38Annular pancreas (HP:0001734)2.69123692
39Complement deficiency (HP:0004431)2.67383527
40Anxiety (HP:0000739)2.67105183
41Abnormal social behavior (HP:0012433)2.66156190
42Impaired social interactions (HP:0000735)2.66156190
43Erythema (HP:0010783)2.63582385
44Dysmetria (HP:0001310)2.62159165
45Popliteal pterygium (HP:0009756)2.61116484
46Palmar hyperkeratosis (HP:0010765)2.61020812
47Malnutrition (HP:0004395)2.58756724
48Testicular atrophy (HP:0000029)2.58488482
49Abnormality of the salivary glands (HP:0010286)2.53488851
50Urinary bladder sphincter dysfunction (HP:0002839)2.51741369
51Gaze-evoked nystagmus (HP:0000640)2.51446838
52Cerebral aneurysm (HP:0004944)2.48019543
53Postural instability (HP:0002172)2.47554290
54Abnormality of renin-angiotensin system (HP:0000847)2.47222782
55Congenital ichthyosiform erythroderma (HP:0007431)2.43120474
56Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.42897990
57Craniofacial dystonia (HP:0012179)2.42462369
58Myopathic facies (HP:0002058)2.40902441
59Plantar hyperkeratosis (HP:0007556)2.40829248
60Termporal pattern (HP:0011008)2.40174142
61Insidious onset (HP:0003587)2.40174142
62Supranuclear gaze palsy (HP:0000605)2.39429314
63Impaired vibratory sensation (HP:0002495)2.39152540
64Neonatal onset (HP:0003623)2.37266869
65Aplasia involving bones of the upper limbs (HP:0009823)2.35485628
66Aplasia of the phalanges of the hand (HP:0009802)2.35485628
67Aplasia involving bones of the extremities (HP:0009825)2.35485628
68Mildly elevated creatine phosphokinase (HP:0008180)2.34006191
69Gout (HP:0001997)2.33978241
70Alopecia of scalp (HP:0002293)2.33442846
71Ankyloglossia (HP:0010296)2.31712135
72Hemiplegia (HP:0002301)2.30612971
73Achilles tendon contracture (HP:0001771)2.29394037
74Dysmetric saccades (HP:0000641)2.27864547
75Hemorrhage of the eye (HP:0011885)2.26523024
76Intention tremor (HP:0002080)2.26070072
77Abnormality of nail color (HP:0100643)2.25969293
78Urinary urgency (HP:0000012)2.25541026
79Glomerulonephritis (HP:0000099)2.24886606
80Fetal akinesia sequence (HP:0001989)2.24630216
81Mesangial abnormality (HP:0001966)2.23124394
82Status epilepticus (HP:0002133)2.22534911
83Alacrima (HP:0000522)2.20826846
84Axonal loss (HP:0003447)2.18261963
85Polyphagia (HP:0002591)2.16036142
86Bundle branch block (HP:0011710)2.13304745
87Rapidly progressive (HP:0003678)2.13211047
88Genetic anticipation (HP:0003743)2.11668290
89Abnormality of the Achilles tendon (HP:0005109)2.11398862
90Ventricular tachycardia (HP:0004756)2.10937032
91Erythroderma (HP:0001019)2.07441278
92Broad metatarsal (HP:0001783)2.05571835
93Amelogenesis imperfecta (HP:0000705)2.05047704
94Hypokalemic alkalosis (HP:0001949)2.04681738
95Increased variability in muscle fiber diameter (HP:0003557)2.04315512
96Bradykinesia (HP:0002067)2.02720274
97Lower limb amyotrophy (HP:0007210)2.02425877
98Abnormality of magnesium homeostasis (HP:0004921)2.01852956
99Emphysema (HP:0002097)2.01247347
100Cerebral inclusion bodies (HP:0100314)1.99757704
101Generalized myoclonic seizures (HP:0002123)1.99744259
102Obstructive sleep apnea (HP:0002870)1.99594705
103Incomplete penetrance (HP:0003829)1.97752905
104Abnormality of secondary sexual hair (HP:0009888)1.96446466
105Abnormality of the axillary hair (HP:0100134)1.96446466
106Acanthosis nigricans (HP:0000956)1.96075577
107Truncal ataxia (HP:0002078)1.95377916
108Stereotypic behavior (HP:0000733)1.94914804
109Papilledema (HP:0001085)1.94780129
110Scanning speech (HP:0002168)1.94303416
111Ulnar bowing (HP:0003031)1.94192489
112Nephritis (HP:0000123)1.93975340
113Mutism (HP:0002300)1.93936564
114Hemiparesis (HP:0001269)1.93364302
115Neuronal loss in central nervous system (HP:0002529)1.92670065
116Increased connective tissue (HP:0009025)1.92102205
117Inability to walk (HP:0002540)1.90064909
118Coronal craniosynostosis (HP:0004440)1.89261270
119Stridor (HP:0010307)1.89030992
120Lymphangioma (HP:0100764)1.88912232
121Shallow orbits (HP:0000586)1.88550743
122Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86446371
123Megalencephaly (HP:0001355)1.85904362
124Progressive inability to walk (HP:0002505)1.85479115
125Syncope (HP:0001279)1.85287543
126Protrusio acetabuli (HP:0003179)1.84676000
127Gonadal dysgenesis (HP:0000133)1.84668528
128Fragile nails (HP:0001808)1.83854880
129Choanal stenosis (HP:0000452)1.83356974
130Neonatal short-limb short stature (HP:0008921)1.82556887
131Onycholysis (HP:0001806)1.82311768
132Decreased circulating renin level (HP:0003351)1.82183318
133Abnormal atrioventricular conduction (HP:0005150)1.81821777
134Thick nail (HP:0001805)1.81262453
135Distal lower limb muscle weakness (HP:0009053)1.80952102
136Follicular hyperkeratosis (HP:0007502)1.80185120
137Impaired smooth pursuit (HP:0007772)1.79555154
138Milia (HP:0001056)1.79194739
139Peripheral hypomyelination (HP:0007182)1.78756755
140Neurofibrillary tangles (HP:0002185)1.78620053
141Exercise-induced myalgia (HP:0003738)1.78617592
142Excessive salivation (HP:0003781)1.77447114
143Drooling (HP:0002307)1.77447114
144Sudden death (HP:0001699)1.76080696
145Lower limb muscle weakness (HP:0007340)1.75711909
146Spastic gait (HP:0002064)1.74781140
147Atrioventricular block (HP:0001678)1.74608532
148Distal lower limb amyotrophy (HP:0008944)1.72798772
149Bilateral sensorineural hearing impairment (HP:0008619)1.72620580
150Diminished movement (HP:0002374)1.71748443
151Conjunctival hamartoma (HP:0100780)1.71596899
152Epileptiform EEG discharges (HP:0011182)1.71485685
153Heart block (HP:0012722)1.71349315
154Thin bony cortex (HP:0002753)1.71340076
155Hypoventilation (HP:0002791)1.70878938
156Abnormal blistering of the skin (HP:0008066)1.70444769
157Abnormality of binocular vision (HP:0011514)1.70125652
158Diplopia (HP:0000651)1.70125652
159Sleep apnea (HP:0010535)1.69679109
160Rigidity (HP:0002063)1.69483053
161Mask-like facies (HP:0000298)1.69324223
162Palmoplantar keratoderma (HP:0000982)1.69217542
163Delusions (HP:0000746)1.69213375
164Hypotrichosis (HP:0001006)1.68904208
165Oligomenorrhea (HP:0000876)1.68869199
166Increased circulating renin level (HP:0000848)1.68166524
167Distal upper limb amyotrophy (HP:0007149)1.66680669
168Upper limb amyotrophy (HP:0009129)1.66680669
169Ulnar claw (HP:0001178)1.66648259
170Bronchomalacia (HP:0002780)1.66401805
171Hammertoe (HP:0001765)1.65323365
172Intellectual disability, profound (HP:0002187)1.65077269
173Hypercortisolism (HP:0001578)1.61362756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.06772397
2MAP3K93.99378536
3STK393.80201514
4NTRK33.71700941
5DAPK22.79165055
6KSR22.72374907
7MAPK152.58437371
8MAP3K122.38241994
9PRKD32.35317506
10MAP3K42.31881541
11PAK62.31680224
12MINK12.09312272
13GRK52.04461454
14ARAF1.99822733
15EPHA21.97918994
16MAP2K41.90763915
17EEF2K1.90613168
18TAOK11.90564279
19NTRK11.85206321
20DAPK11.82885026
21ERN11.78554040
22RIPK41.67123617
23TYRO31.64604162
24MAP2K71.59673779
25TESK11.57679680
26NTRK21.56757808
27CAMKK11.55179204
28PRKG21.54896759
29SIK11.54869825
30LATS21.53226399
31KSR11.49878243
32MAP3K21.47306252
33TIE11.46730851
34STK381.44942215
35CDK191.44014016
36MAPK121.42005758
37MAP2K61.32672800
38CDK51.31350150
39MAP3K131.29155471
40OXSR11.26547804
41PLK21.24156223
42MOS1.17251777
43PRPF4B1.11262457
44PTK2B1.08414953
45PRKCG1.07047184
46RAF11.06695975
47CASK1.05168692
48BMPR20.98241272
49PINK10.94008347
50FER0.93798949
51MAP2K10.88446439
52MAPKAPK30.88422982
53MAP3K10.87911905
54MARK10.87216380
55MAP3K110.87171513
56CAMK2A0.86222546
57STK110.84712814
58NEK10.83678507
59SIK20.80291419
60AKT30.78233667
61CAMKK20.76842725
62CAMK10.76786297
63MARK20.75253709
64SGK4940.74464676
65SGK2230.74464676
66PRKCH0.74282787
67CDK180.74143791
68MAP3K60.74076816
69PDGFRA0.73444437
70DAPK30.73366873
71RIPK10.72884479
72PBK0.72856955
73CDK150.72850614
74BRAF0.72773494
75RET0.70881074
76CDK140.70849361
77DDR20.69826046
78MST1R0.69773883
79PAK30.69479157
80PDPK10.68460053
81LMTK20.67052315
82PTK20.64118600
83CAMK2B0.62538216
84ICK0.62413559
85ROCK10.60916714
86CDK11A0.60873679
87PDK10.60469115
88RPS6KA20.58983519
89SGK10.57266809
90FES0.57140958
91NEK60.53369435
92SGK30.53261217
93PRKAA20.53074118
94SGK20.52309418
95SMG10.50301681
96PDK30.49964538
97PDK40.49964538
98EPHB20.49201810
99WNK40.48770498
100ABL20.47957030
101DMPK0.47472945
102MAP3K70.47469734
103PRKD20.46624632
104TRIB30.46174174
105BRSK10.45072865
106MAPK130.44887618
107PKN10.44872521
108ADRBK10.44195754
109PRKCE0.44022812
110MUSK0.43976459
111ALK0.43848311
112MAPK70.43482978
113NME10.43470077
114CAMK40.42761078
115CDC42BPA0.42661764
116RPS6KA30.42485890
117FGFR40.41956092
118CAMK2G0.41947068
119PRKD10.41453825
120MYLK0.41316372
121PHKG10.40585220
122PHKG20.40585220
123TNK20.40359699
124MET0.40170766
125PRKCZ0.39882473
126UHMK10.39421480
127GRK60.38564423
128MAPKAPK50.38504782
129BMX0.38052377
130PRKCI0.37365874
131PAK10.37160924
132MAPK100.36985125
133ERBB20.35560451

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.28037563
2Nicotine addiction_Homo sapiens_hsa050332.93851961
3Olfactory transduction_Homo sapiens_hsa047402.64239153
4Long-term potentiation_Homo sapiens_hsa047202.40598793
5Circadian entrainment_Homo sapiens_hsa047132.33230834
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25597696
7GABAergic synapse_Homo sapiens_hsa047272.25469672
8Amphetamine addiction_Homo sapiens_hsa050312.22548711
9Glutamatergic synapse_Homo sapiens_hsa047242.22512285
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20795446
11Salivary secretion_Homo sapiens_hsa049702.12787872
12Morphine addiction_Homo sapiens_hsa050322.04496441
13Collecting duct acid secretion_Homo sapiens_hsa049662.03030361
14Gastric acid secretion_Homo sapiens_hsa049711.96010253
15Dopaminergic synapse_Homo sapiens_hsa047281.80039173
16Renin secretion_Homo sapiens_hsa049241.73446064
17Sulfur relay system_Homo sapiens_hsa041221.71485662
18Oxytocin signaling pathway_Homo sapiens_hsa049211.68760128
19Insulin secretion_Homo sapiens_hsa049111.68455622
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64850382
21GnRH signaling pathway_Homo sapiens_hsa049121.63452986
22Histidine metabolism_Homo sapiens_hsa003401.58624723
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56533779
24Cholinergic synapse_Homo sapiens_hsa047251.55105477
25Calcium signaling pathway_Homo sapiens_hsa040201.53648505
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53285951
27Long-term depression_Homo sapiens_hsa047301.53054601
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50922448
29Taste transduction_Homo sapiens_hsa047421.50004382
30Cocaine addiction_Homo sapiens_hsa050301.41545127
31Serotonergic synapse_Homo sapiens_hsa047261.37683444
32Gap junction_Homo sapiens_hsa045401.36761674
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33270835
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32377250
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30083184
36Protein digestion and absorption_Homo sapiens_hsa049741.27863505
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.24160764
38Nitrogen metabolism_Homo sapiens_hsa009101.22575375
39cAMP signaling pathway_Homo sapiens_hsa040241.21079773
40Glioma_Homo sapiens_hsa052141.18118474
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16656904
42Arginine and proline metabolism_Homo sapiens_hsa003301.14871803
43Vitamin digestion and absorption_Homo sapiens_hsa049771.11253519
44Vibrio cholerae infection_Homo sapiens_hsa051101.10561768
45Estrogen signaling pathway_Homo sapiens_hsa049151.07673145
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06905941
47Melanogenesis_Homo sapiens_hsa049161.04398955
48Notch signaling pathway_Homo sapiens_hsa043301.04264611
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.04051360
50ECM-receptor interaction_Homo sapiens_hsa045121.02989242
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01922578
52Fructose and mannose metabolism_Homo sapiens_hsa000511.01616084
53Cardiac muscle contraction_Homo sapiens_hsa042601.01468033
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99693826
55ErbB signaling pathway_Homo sapiens_hsa040120.96524807
56Fat digestion and absorption_Homo sapiens_hsa049750.96221798
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96020038
58Prion diseases_Homo sapiens_hsa050200.95554757
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94596895
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93751766
61Dilated cardiomyopathy_Homo sapiens_hsa054140.93187079
62Axon guidance_Homo sapiens_hsa043600.87677821
63Folate biosynthesis_Homo sapiens_hsa007900.87662028
64Thyroid hormone synthesis_Homo sapiens_hsa049180.87282776
65Mineral absorption_Homo sapiens_hsa049780.84649428
66VEGF signaling pathway_Homo sapiens_hsa043700.84459976
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.81873777
68PPAR signaling pathway_Homo sapiens_hsa033200.80393827
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78943279
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76628624
71Choline metabolism in cancer_Homo sapiens_hsa052310.76308262
72Oocyte meiosis_Homo sapiens_hsa041140.74177619
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73133765
74Rap1 signaling pathway_Homo sapiens_hsa040150.72480128
75Type II diabetes mellitus_Homo sapiens_hsa049300.72432918
76Pertussis_Homo sapiens_hsa051330.71579301
77Ovarian steroidogenesis_Homo sapiens_hsa049130.70378034
78Pancreatic secretion_Homo sapiens_hsa049720.70037249
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69587512
80Vitamin B6 metabolism_Homo sapiens_hsa007500.69163315
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69146119
82Bile secretion_Homo sapiens_hsa049760.68283491
83Linoleic acid metabolism_Homo sapiens_hsa005910.68090823
84Ras signaling pathway_Homo sapiens_hsa040140.66588868
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66015500
86MAPK signaling pathway_Homo sapiens_hsa040100.65793189
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63428004
88Phenylalanine metabolism_Homo sapiens_hsa003600.61927937
89Staphylococcus aureus infection_Homo sapiens_hsa051500.60492220
90mTOR signaling pathway_Homo sapiens_hsa041500.58980428
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58612752
92Ether lipid metabolism_Homo sapiens_hsa005650.58439775
93Arachidonic acid metabolism_Homo sapiens_hsa005900.58399880
94Circadian rhythm_Homo sapiens_hsa047100.57316916
95Lysosome_Homo sapiens_hsa041420.57125944
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56824894
97Sphingolipid metabolism_Homo sapiens_hsa006000.56811090
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56590827
99Arginine biosynthesis_Homo sapiens_hsa002200.55674165
100Glucagon signaling pathway_Homo sapiens_hsa049220.55452233
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54926813
102Inositol phosphate metabolism_Homo sapiens_hsa005620.54619906
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.53951539
104Tight junction_Homo sapiens_hsa045300.53092599
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51203441
106Endocytosis_Homo sapiens_hsa041440.50894465
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49852031
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49045343
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47625764
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.46258670
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42255300
112Non-small cell lung cancer_Homo sapiens_hsa052230.42023990
113Renal cell carcinoma_Homo sapiens_hsa052110.39880339
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.39385946
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37924561
116Phototransduction_Homo sapiens_hsa047440.37532334
117Endometrial cancer_Homo sapiens_hsa052130.37249075
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.36659446
119Fatty acid biosynthesis_Homo sapiens_hsa000610.35077749
120Insulin signaling pathway_Homo sapiens_hsa049100.35024876
121Focal adhesion_Homo sapiens_hsa045100.34143834
122Wnt signaling pathway_Homo sapiens_hsa043100.33963250
123Hippo signaling pathway_Homo sapiens_hsa043900.32876560
124Alzheimers disease_Homo sapiens_hsa050100.32210818
125Hedgehog signaling pathway_Homo sapiens_hsa043400.31633278
126Amoebiasis_Homo sapiens_hsa051460.30969051
127Bladder cancer_Homo sapiens_hsa052190.30655161

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