IL36B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)6.60996026
2positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)6.45377453
3regulation of vitamin D biosynthetic process (GO:0060556)4.94756389
4regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.69280186
5glycosphingolipid catabolic process (GO:0046479)4.61973890
6establishment of skin barrier (GO:0061436)4.41938474
7oligosaccharide catabolic process (GO:0009313)4.37574853
8eosinophil chemotaxis (GO:0048245)4.34883801
9glycolipid catabolic process (GO:0019377)4.12592426
10regulation of water loss via skin (GO:0033561)4.00615976
11cellular response to thyroid hormone stimulus (GO:0097067)3.93648709
12positive regulation of chemokine biosynthetic process (GO:0045080)3.91257193
13response to peptidoglycan (GO:0032494)3.85141549
14eosinophil migration (GO:0072677)3.84463678
15regulation of vitamin metabolic process (GO:0030656)3.78859502
16cellular response to arsenic-containing substance (GO:0071243)3.76513160
17negative regulation of interleukin-17 production (GO:0032700)3.74559273
18ceramide catabolic process (GO:0046514)3.73877069
19regulation of monocyte differentiation (GO:0045655)3.70584149
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.70389058
21positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.66216375
22osteoclast differentiation (GO:0030316)3.64602941
23regulation of chronic inflammatory response (GO:0002676)3.53772745
24negative regulation of lipid storage (GO:0010888)3.52331056
25regulation of membrane protein ectodomain proteolysis (GO:0051043)3.51441750
26regulation of mononuclear cell migration (GO:0071675)3.51256863
27positive regulation of monocyte chemotaxis (GO:0090026)3.50497316
28negative regulation of nitric oxide biosynthetic process (GO:0045019)3.48733084
29myeloid dendritic cell differentiation (GO:0043011)3.45632544
30regulation of podosome assembly (GO:0071801)3.38467795
31regulation of cholesterol storage (GO:0010885)3.37909272
32lipoxygenase pathway (GO:0019372)3.32899602
33positive regulation of heat generation (GO:0031652)3.32501969
34keratinocyte differentiation (GO:0030216)3.32448061
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.32052762
36neutrophil activation involved in immune response (GO:0002283)3.31598916
37regulation of chemokine biosynthetic process (GO:0045073)3.28773217
38positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.27814346
39decidualization (GO:0046697)3.26917228
40membrane lipid catabolic process (GO:0046466)3.26201739
41protein localization to endosome (GO:0036010)3.24107589
42negative regulation of interleukin-12 production (GO:0032695)3.22187229
43amino sugar catabolic process (GO:0046348)3.20494062
44regulation of T-helper 1 cell differentiation (GO:0045625)3.19248931
45monocyte chemotaxis (GO:0002548)3.13366656
46regulation of fever generation (GO:0031620)3.13340168
47response to thyroid hormone (GO:0097066)3.12661193
48sphingolipid catabolic process (GO:0030149)3.11477788
49positive regulation of osteoclast differentiation (GO:0045672)3.10052845
50regulation of lymphocyte chemotaxis (GO:1901623)3.03319188
51granulocyte activation (GO:0036230)3.01002736
52response to lipoprotein particle (GO:0055094)2.83442430
53* positive regulation of interleukin-6 production (GO:0032755)2.82223146
54positive regulation of leukocyte degranulation (GO:0043302)2.82097430
55myeloid dendritic cell activation (GO:0001773)2.78787451
56positive regulation of macrophage differentiation (GO:0045651)2.77553990
57sphingosine metabolic process (GO:0006670)2.74887785
58regulation of nitric oxide biosynthetic process (GO:0045428)2.74395763
59positive regulation of extracellular matrix organization (GO:1903055)2.72941053
60macrophage activation involved in immune response (GO:0002281)2.72650934
61skin morphogenesis (GO:0043589)2.71291497
62regulation of monocyte chemotaxis (GO:0090025)2.70759774
63positive regulation of cellular amide metabolic process (GO:0034250)2.70130383
64regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.68793593
65negative regulation of interferon-gamma production (GO:0032689)2.67575814
66positive regulation of NF-kappaB import into nucleus (GO:0042346)2.67504116
67regulation of interleukin-17 production (GO:0032660)2.66870356
68regulation of cytokine secretion involved in immune response (GO:0002739)2.66321256
69regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.66109098
70linoleic acid metabolic process (GO:0043651)2.65832435
71fat-soluble vitamin biosynthetic process (GO:0042362)2.64840437
72detection of other organism (GO:0098543)2.64263712
73positive regulation of bone remodeling (GO:0046852)2.63877894
74positive regulation of bone resorption (GO:0045780)2.63877894
75sphingoid metabolic process (GO:0046519)2.63310794
76detection of bacterium (GO:0016045)2.62331059
77positive regulation of tissue remodeling (GO:0034105)2.62100269
78peptide cross-linking (GO:0018149)2.61782336
79cellular response to lipopolysaccharide (GO:0071222)2.60453089
80positive regulation of p38MAPK cascade (GO:1900745)2.59938994
81positive regulation of cholesterol efflux (GO:0010875)2.59743794
82* regulation of interleukin-6 production (GO:0032675)2.58817099
83positive regulation of mast cell activation (GO:0033005)2.56988899
84keratinocyte proliferation (GO:0043616)2.56960529
85phagosome maturation (GO:0090382)2.56753142
86germinal center formation (GO:0002467)2.55652587
87positive regulation of toll-like receptor signaling pathway (GO:0034123)2.55035585
88pinocytosis (GO:0006907)2.54031167
89T-helper 1 type immune response (GO:0042088)2.52874819
90positive regulation of type 2 immune response (GO:0002830)2.51578241
91cellular response to molecule of bacterial origin (GO:0071219)2.50232183
92chronic inflammatory response (GO:0002544)2.48285990
93positive regulation of nitric oxide biosynthetic process (GO:0045429)2.46843096
94regulation of natural killer cell activation (GO:0032814)2.46291530
95diol metabolic process (GO:0034311)2.46228991
96negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.45571056
97negative regulation of cytokine production involved in immune response (GO:0002719)2.44739186
98regulation of macrophage derived foam cell differentiation (GO:0010743)2.44223537
99negative regulation of cytokine secretion (GO:0050710)2.43360164
100positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.43055688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.10843855
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.03770429
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.93173709
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.60418316
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.27213860
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.26801346
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.20976689
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.09077655
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94781715
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.89542863
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82918709
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82814522
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46942857
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45233210
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43476574
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35861687
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28151293
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20292539
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01653534
20VDR_24787735_ChIP-Seq_THP-1_Human2.01261412
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89504281
22NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.85019235
23JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82677838
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.82569177
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79271484
26JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74778200
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71132778
28SCL_19346495_ChIP-Seq_HPC-7_Human1.70368423
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70357209
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70357209
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69940243
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66419183
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.64895603
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.63618852
35SPI1_23127762_ChIP-Seq_K562_Human1.57660282
36GATA1_22025678_ChIP-Seq_K562_Human1.56014555
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55255588
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51051387
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49521324
40P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48884520
41CJUN_26792858_Chip-Seq_BT549_Human1.45887155
42EGR1_19032775_ChIP-ChIP_M12_Human1.42789495
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.42277964
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40269058
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36897522
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30670866
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29309353
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28174972
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28134360
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.25867139
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24041779
52GATA1_19941826_ChIP-Seq_K562_Human1.23232595
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22668608
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21625196
55SOX2_20726797_ChIP-Seq_SW620_Human1.19890644
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17342140
57PU_27001747_Chip-Seq_BMDM_Mouse1.17050738
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16542439
59TP63_23658742_ChIP-Seq_EP156T_Human1.16131735
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15822875
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.15394049
62RUNX_20019798_ChIP-Seq_JUKART_Human1.14000347
63VDR_24763502_ChIP-Seq_THP-1_Human1.13332194
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12403938
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12403938
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.11074275
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10773954
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10091237
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08972122
70TFEB_21752829_ChIP-Seq_HELA_Human1.08491292
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07288598
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04767546
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03241802
74GATA2_19941826_ChIP-Seq_K562_Human1.00272318
75UBF1/2_26484160_Chip-Seq_HMECs_Human0.98660173
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97628391
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97333106
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96359003
79GATA1_19941827_ChIP-Seq_MEL_Mouse0.96019042
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94870286
81TP53_16413492_ChIP-PET_HCT116_Human0.93132341
82ATF3_27146783_Chip-Seq_COLON_Human0.92648240
83FOXO3_23340844_ChIP-Seq_DLD1_Human0.92570064
84SPI1_23547873_ChIP-Seq_NB4_Human0.92222221
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90321763
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90127628
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89430309
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88747157
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85692387
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85424952
91LXR_22292898_ChIP-Seq_THP-1_Human0.84747029
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84251935
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83919149
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83553490
95BRD4_25478319_ChIP-Seq_HGPS_Human0.83318944
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83266699
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83171275
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78814267
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78186953
100RXR_22108803_ChIP-Seq_LS180_Human0.76862521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.77019790
2MP0009840_abnormal_foam_cell3.49251396
3MP0005058_abnormal_lysosome_morphology3.42691004
4MP0002796_impaired_skin_barrier3.39496972
5MP0003191_abnormal_cellular_cholesterol3.37333981
6MP0006082_CNS_inflammation3.09603345
7MP0003453_abnormal_keratinocyte_physiol2.97867578
8MP0004510_myositis2.77397105
9MP0002148_abnormal_hypersensitivity_rea2.63920120
10MP0004947_skin_inflammation2.63399998
11MP0002139_abnormal_hepatobiliary_system2.55819468
12MP0000343_altered_response_to2.45714188
13MP0003724_increased_susceptibility_to2.43641317
14MP0003172_abnormal_lysosome_physiology2.38570851
15MP0003950_abnormal_plasma_membrane2.33461821
16MP0003436_decreased_susceptibility_to2.23282693
17MP0005451_abnormal_body_composition2.22911423
18MP0002877_abnormal_melanocyte_morpholog2.12964743
19MP0009785_altered_susceptibility_to2.07673927
20MP0001853_heart_inflammation2.05434409
21MP0005671_abnormal_response_to2.03011415
22MP0000604_amyloidosis2.02900139
23MP0010234_abnormal_vibrissa_follicle2.02144693
24MP0002998_abnormal_bone_remodeling2.02079280
25MP0002419_abnormal_innate_immunity1.98402661
26MP0008004_abnormal_stomach_pH1.98185231
27MP0005464_abnormal_platelet_physiology1.95931725
28MP0003300_gastrointestinal_ulcer1.95364610
29MP0005000_abnormal_immune_tolerance1.85094565
30MP0005387_immune_system_phenotype1.77398980
31MP0001790_abnormal_immune_system1.77398980
32MP0005275_abnormal_skin_tensile1.74415348
33MP0010678_abnormal_skin_adnexa1.64956555
34MP0009764_decreased_sensitivity_to1.64909635
35MP0009333_abnormal_splenocyte_physiolog1.64094304
36MP0005025_abnormal_response_to1.62802836
37MP0001216_abnormal_epidermal_layer1.62377283
38MP0005501_abnormal_skin_physiology1.60895383
39MP0001533_abnormal_skeleton_physiology1.58683416
40MP0001835_abnormal_antigen_presentation1.53422277
41MP0000383_abnormal_hair_follicle1.48986826
42MP0002452_abnormal_antigen_presenting1.48474065
43MP0003075_altered_response_to1.40817996
44MP0006054_spinal_hemorrhage1.39997468
45MP0003690_abnormal_glial_cell1.37540722
46MP0003656_abnormal_erythrocyte_physiolo1.37522855
47MP0002723_abnormal_immune_serum1.33075391
48MP0005647_abnormal_sex_gland1.29147432
49MP0005023_abnormal_wound_healing1.27482531
50MP0003806_abnormal_nucleotide_metabolis1.26350303
51MP0000579_abnormal_nail_morphology1.24609857
52MP0001845_abnormal_inflammatory_respons1.24102437
53MP0003448_altered_tumor_morphology1.22025732
54MP0001545_abnormal_hematopoietic_system1.20409363
55MP0005397_hematopoietic_system_phenotyp1.20409363
56MP0001542_abnormal_bone_strength1.17648706
57MP0003091_abnormal_cell_migration1.17114268
58MP0003329_amyloid_beta_deposits1.16809821
59MP0000371_diluted_coat_color1.14831975
60MP0010155_abnormal_intestine_physiology1.14717960
61MP0002332_abnormal_exercise_endurance1.12658863
62MP0010352_gastrointestinal_tract_polyps1.12552407
63MP0001851_eye_inflammation1.11077338
64MP0009379_abnormal_foot_pigmentation1.10220536
65MP0003705_abnormal_hypodermis_morpholog1.09324158
66MP0009278_abnormal_bone_marrow1.09296206
67MP0002405_respiratory_system_inflammati1.09028641
68MP0001800_abnormal_humoral_immune1.09004972
69MP0005167_abnormal_blood-brain_barrier1.07374421
70MP0002254_reproductive_system_inflammat1.05899142
71MP0005164_abnormal_response_to1.05726835
72MP0000920_abnormal_myelination1.05506029
73MP0005310_abnormal_salivary_gland1.05401235
74MP0002420_abnormal_adaptive_immunity1.04047360
75MP0001819_abnormal_immune_cell1.03448024
76MP0003195_calcinosis0.97314650
77MP0008469_abnormal_protein_level0.94149984
78MP0000858_altered_metastatic_potential0.92510805
79MP0003828_pulmonary_edema0.91651671
80MP0005166_decreased_susceptibility_to0.91458507
81MP0005595_abnormal_vascular_smooth0.87417201
82MP0001191_abnormal_skin_condition0.86582121
83MP0000685_abnormal_immune_system0.84251294
84MP0000569_abnormal_digit_pigmentation0.83981683
85MP0010386_abnormal_urinary_bladder0.82547278
86MP0002098_abnormal_vibrissa_morphology0.79513929
87MP0010771_integument_phenotype0.78361647
88MP0009763_increased_sensitivity_to0.76903456
89MP0001727_abnormal_embryo_implantation0.75701685
90MP0003879_abnormal_hair_cell0.75680993
91MP0005390_skeleton_phenotype0.74007124
92MP0008874_decreased_physiological_sensi0.72439114
93MP0003566_abnormal_cell_adhesion0.72340223
94MP0004185_abnormal_adipocyte_glucose0.71312456
95MP0003795_abnormal_bone_structure0.71289669
96MP0005666_abnormal_adipose_tissue0.69680337
97MP0009765_abnormal_xenobiotic_induced0.68929846
98MP0004808_abnormal_hematopoietic_stem0.68929144
99MP0005257_abnormal_intraocular_pressure0.68704543
100MP0002095_abnormal_skin_pigmentation0.67714622

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)7.61170202
2Abnormality of glycolipid metabolism (HP:0010969)7.61170202
3Abnormality of liposaccharide metabolism (HP:0010968)7.61170202
4Increased cerebral lipofuscin (HP:0011813)4.95798257
5Increased IgE level (HP:0003212)4.57613995
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.55616688
7Parakeratosis (HP:0001036)4.32727711
8Abnormality of nail color (HP:0100643)4.28908813
9Nuclear cataract (HP:0100018)4.27949652
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.20423141
11Loss of speech (HP:0002371)4.17817908
12Abnormality of macrophages (HP:0004311)4.12241977
13Myocardial infarction (HP:0001658)3.95923348
14Vacuolated lymphocytes (HP:0001922)3.94763981
15Congenital ichthyosiform erythroderma (HP:0007431)3.85346708
16Dysostosis multiplex (HP:0000943)3.79968413
17Neurofibrillary tangles (HP:0002185)3.77763308
18Eczematoid dermatitis (HP:0000976)3.77660052
19Erythroderma (HP:0001019)3.64827011
20Disinhibition (HP:0000734)3.62122948
21Palmoplantar hyperkeratosis (HP:0000972)3.43741363
22Axonal loss (HP:0003447)3.38381168
23Thick nail (HP:0001805)3.35603344
24Pustule (HP:0200039)3.26886341
25Palmar hyperkeratosis (HP:0010765)3.20857337
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.19991992
27Interstitial pulmonary disease (HP:0006530)3.16906717
28Tetraparesis (HP:0002273)3.12588471
29Recurrent bacterial skin infections (HP:0005406)3.07202365
30Erythema (HP:0010783)3.05863957
31Mutism (HP:0002300)2.97841734
32Systemic lupus erythematosus (HP:0002725)2.94995267
33Cerebral inclusion bodies (HP:0100314)2.91843207
34Autoimmune thrombocytopenia (HP:0001973)2.86018467
35Gangrene (HP:0100758)2.77128721
36Abnormality of polysaccharide metabolism (HP:0011012)2.74954674
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74954674
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74954674
39Plantar hyperkeratosis (HP:0007556)2.65118681
40Stomatitis (HP:0010280)2.64576567
41Vertebral compression fractures (HP:0002953)2.59964758
42Mucopolysacchariduria (HP:0008155)2.56932111
43Urinary glycosaminoglycan excretion (HP:0003541)2.56932111
44Apathy (HP:0000741)2.56809710
45Diminished motivation (HP:0000745)2.54200959
46Oral leukoplakia (HP:0002745)2.42976159
47Purpura (HP:0000979)2.39914802
48Metaphyseal irregularity (HP:0003025)2.39654575
49Recurrent abscess formation (HP:0002722)2.39127462
50Alopecia of scalp (HP:0002293)2.35630123
51Increased serum ferritin (HP:0003281)2.33368821
52Corneal erosion (HP:0200020)2.32819111
53Osteolytic defects of the hand bones (HP:0009699)2.29898856
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.29898856
55Petechiae (HP:0000967)2.28163232
56Prolonged neonatal jaundice (HP:0006579)2.25906515
57Hypohidrosis (HP:0000966)2.24354116
58Neuronal loss in central nervous system (HP:0002529)2.23755351
59Hepatosplenomegaly (HP:0001433)2.15988768
60Supranuclear gaze palsy (HP:0000605)2.14937480
61Hypergammaglobulinemia (HP:0010702)2.13494756
62Xanthomatosis (HP:0000991)2.10903644
63Paralysis (HP:0003470)2.06507493
64Mediastinal lymphadenopathy (HP:0100721)2.04908094
65Bone pain (HP:0002653)1.98871308
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98768428
67Ectropion (HP:0000656)1.96638190
68Progressive neurologic deterioration (HP:0002344)1.94474812
69Onycholysis (HP:0001806)1.93121519
70Natal tooth (HP:0000695)1.93074773
71Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92471730
72Nail dystrophy (HP:0008404)1.92062816
73Upper motor neuron abnormality (HP:0002127)1.90310076
74Nausea (HP:0002018)1.89350861
75Abnormality of secondary sexual hair (HP:0009888)1.88476331
76Abnormality of the axillary hair (HP:0100134)1.88476331
77Abnormality of iron homeostasis (HP:0011031)1.86965638
78Inappropriate behavior (HP:0000719)1.86571773
79Basal ganglia calcification (HP:0002135)1.84931395
80Dementia (HP:0000726)1.84192134
81Asymmetric septal hypertrophy (HP:0001670)1.84112811
82Abnormality of the costochondral junction (HP:0000919)1.83965041
83Recurrent gram-negative bacterial infections (HP:0005420)1.83707248
84Premature loss of primary teeth (HP:0006323)1.81799928
85Keratoconjunctivitis sicca (HP:0001097)1.81532791
86Protuberant abdomen (HP:0001538)1.79084046
87Thin bony cortex (HP:0002753)1.79020352
88Pruritus (HP:0000989)1.77832963
89Orchitis (HP:0100796)1.77250945
90Optic neuritis (HP:0100653)1.75510517
91Retrobulbar optic neuritis (HP:0100654)1.75510517
92Hypotrichosis (HP:0001006)1.74376610
93Urticaria (HP:0001025)1.70186821
94Zonular cataract (HP:0010920)1.70142569
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69731513
96Malnutrition (HP:0004395)1.68770939
97Segmental peripheral demyelination/remyelination (HP:0003481)1.68515604
98Recurrent skin infections (HP:0001581)1.63940358
99Amyloidosis (HP:0011034)1.63829793
100Skin nodule (HP:0200036)1.60462444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK37.02970327
2MOS3.14794646
3DDR23.10211035
4NME22.85960969
5TAOK22.79919374
6GRK72.72724668
7MAP3K32.46472401
8MAP3K142.24537767
9TBK12.02666099
10ERBB41.99896381
11TAOK11.83384670
12STK241.79647993
13BMPR21.76220921
14FGR1.73631553
15RIPK41.72139667
16MAP3K111.71614197
17CSK1.71328533
18ABL21.70190982
19IRAK41.66078285
20PIM21.61767248
21IKBKB1.61693789
22ACVR1B1.59799631
23TGFBR21.51872257
24IRAK21.51825444
25MATK1.41203782
26ADRBK21.39261210
27TRPM71.33992970
28BLK1.29216965
29ZAP701.27934528
30MAPK151.23005029
31CDC42BPA1.22723722
32MAP2K31.16290354
33IKBKE1.15783792
34RIPK11.13892601
35IRAK11.10465105
36PRPF4B1.09222920
37LIMK11.07949736
38BMX1.04685215
39MAP3K11.01789096
40CHUK0.98865063
41PKN10.97482522
42MARK30.96572443
43TTN0.90038336
44TYK20.88329433
45TAOK30.87741885
46TXK0.87694802
47SIK30.84773928
48MAP3K90.82081784
49MAP3K130.81932631
50JAK30.81637220
51CAMKK20.80284029
52PDGFRA0.80096572
53ERBB30.79775618
54TESK20.78556960
55PAK60.74488068
56MAP3K50.74387731
57TGFBR10.72438562
58PDGFRB0.72150476
59MAPK70.68528770
60MAP3K60.67470980
61PDK20.67358379
62TESK10.66712839
63JAK10.64441469
64PAK40.62673442
65ERN10.59901362
66SYK0.59540990
67TYRO30.58895537
68HCK0.56835021
69STK100.56258489
70CAMK1D0.56031043
71ABL10.55562252
72PAK20.53937680
73MAPK120.52431565
74PRKG20.51855838
75SGK30.51483370
76JAK20.49200352
77MAPK40.48142740
78GSK3A0.47937978
79MAP4K10.47413189
80CSF1R0.46332702
81PBK0.45878185
82LYN0.45841708
83CAMK1G0.45817406
84MAP2K60.45244781
85NEK90.44707113
86MAP3K20.44266717
87DYRK30.43222729
88CDK60.39798626
89ARAF0.38655455
90LATS20.37508528
91CAMK2G0.37237753
92MAPKAPK20.35029602
93STK30.34861491
94FRK0.34327163
95LCK0.33982373
96MST40.32239288
97MAPK110.31351084
98SIK10.31011420
99PDPK10.30601605
100PLK20.28899320

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.74531592
2Lysosome_Homo sapiens_hsa041423.17295944
3Rheumatoid arthritis_Homo sapiens_hsa053232.94129798
4Other glycan degradation_Homo sapiens_hsa005112.51349321
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.46925546
6Osteoclast differentiation_Homo sapiens_hsa043802.19581660
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.08727402
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.04600689
9Malaria_Homo sapiens_hsa051441.96423270
10TNF signaling pathway_Homo sapiens_hsa046681.94785695
11Collecting duct acid secretion_Homo sapiens_hsa049661.93566925
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91790177
13Staphylococcus aureus infection_Homo sapiens_hsa051501.84355731
14Tuberculosis_Homo sapiens_hsa051521.80565000
15Leishmaniasis_Homo sapiens_hsa051401.78203686
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.76239463
17Pertussis_Homo sapiens_hsa051331.72685837
18Salmonella infection_Homo sapiens_hsa051321.63865507
19Legionellosis_Homo sapiens_hsa051341.59342272
20Sphingolipid metabolism_Homo sapiens_hsa006001.58910738
21Asthma_Homo sapiens_hsa053101.54773690
22Phagosome_Homo sapiens_hsa041451.53711833
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52695455
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46833647
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46547212
26Allograft rejection_Homo sapiens_hsa053301.46055030
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43904010
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39651498
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38447483
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37798691
31Vibrio cholerae infection_Homo sapiens_hsa051101.34357321
32Bladder cancer_Homo sapiens_hsa052191.34005185
33Graft-versus-host disease_Homo sapiens_hsa053321.33011373
34Hematopoietic cell lineage_Homo sapiens_hsa046401.32179284
35Toxoplasmosis_Homo sapiens_hsa051451.21579213
36African trypanosomiasis_Homo sapiens_hsa051431.20800974
37Influenza A_Homo sapiens_hsa051641.19040536
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.16007710
39Chemokine signaling pathway_Homo sapiens_hsa040621.13244168
40VEGF signaling pathway_Homo sapiens_hsa043701.10959771
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.04869968
42Shigellosis_Homo sapiens_hsa051311.00762974
43Hepatitis C_Homo sapiens_hsa051600.97896469
44Autoimmune thyroid disease_Homo sapiens_hsa053200.97753484
45Amoebiasis_Homo sapiens_hsa051460.97716178
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92084393
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91595596
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89728396
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.86113011
50Antigen processing and presentation_Homo sapiens_hsa046120.84914478
51Fructose and mannose metabolism_Homo sapiens_hsa000510.84131216
52B cell receptor signaling pathway_Homo sapiens_hsa046620.82846857
53Type I diabetes mellitus_Homo sapiens_hsa049400.82719046
54Dorso-ventral axis formation_Homo sapiens_hsa043200.81531764
55Platelet activation_Homo sapiens_hsa046110.80506817
56Galactose metabolism_Homo sapiens_hsa000520.79480202
57Prion diseases_Homo sapiens_hsa050200.78627083
58Viral myocarditis_Homo sapiens_hsa054160.78548028
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.75169695
60Apoptosis_Homo sapiens_hsa042100.74905102
61Hepatitis B_Homo sapiens_hsa051610.70487970
62GnRH signaling pathway_Homo sapiens_hsa049120.70030126
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69245651
64Herpes simplex infection_Homo sapiens_hsa051680.68915770
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68083793
66Mineral absorption_Homo sapiens_hsa049780.66950581
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65866351
68Measles_Homo sapiens_hsa051620.65645767
69Type II diabetes mellitus_Homo sapiens_hsa049300.65348491
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64818137
71Acute myeloid leukemia_Homo sapiens_hsa052210.63537131
72Synaptic vesicle cycle_Homo sapiens_hsa047210.62952661
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.60930900
74PPAR signaling pathway_Homo sapiens_hsa033200.60740322
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60627737
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.58563109
77HIF-1 signaling pathway_Homo sapiens_hsa040660.58175410
78Endocytosis_Homo sapiens_hsa041440.56627624
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56505276
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.56156362
81Ether lipid metabolism_Homo sapiens_hsa005650.55914221
82Notch signaling pathway_Homo sapiens_hsa043300.54162077
83Renal cell carcinoma_Homo sapiens_hsa052110.50515927
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.49120652
85Prolactin signaling pathway_Homo sapiens_hsa049170.48364346
86Pancreatic cancer_Homo sapiens_hsa052120.46963513
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46709723
88T cell receptor signaling pathway_Homo sapiens_hsa046600.46121970
89Arachidonic acid metabolism_Homo sapiens_hsa005900.44807759
90Sulfur metabolism_Homo sapiens_hsa009200.44505152
91Circadian rhythm_Homo sapiens_hsa047100.43952996
92Complement and coagulation cascades_Homo sapiens_hsa046100.41877057
93Long-term depression_Homo sapiens_hsa047300.38239575
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37205329
95Proteoglycans in cancer_Homo sapiens_hsa052050.35800808
96MAPK signaling pathway_Homo sapiens_hsa040100.34177119
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30668178
98ErbB signaling pathway_Homo sapiens_hsa040120.30004813
99Chronic myeloid leukemia_Homo sapiens_hsa052200.29550230
100Ras signaling pathway_Homo sapiens_hsa040140.28771412

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