IL36G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)8.92336919
2keratinocyte differentiation (GO:0030216)8.75124994
3epidermal cell differentiation (GO:0009913)6.65502656
4desmosome organization (GO:0002934)6.35306736
5detection of bacterium (GO:0016045)6.29343055
6detection of other organism (GO:0098543)5.94726839
7hair cycle (GO:0042633)5.70700281
8molting cycle (GO:0042303)5.70700281
9lipoxygenase pathway (GO:0019372)5.58822661
10peptide cross-linking (GO:0018149)5.54889312
11regulation of vitamin D biosynthetic process (GO:0060556)5.47381525
12multicellular organismal water homeostasis (GO:0050891)5.46326068
13keratinocyte proliferation (GO:0043616)5.25604005
14positive regulation of monocyte chemotaxis (GO:0090026)5.24763176
15long-chain fatty acid biosynthetic process (GO:0042759)5.17111294
16epidermis development (GO:0008544)5.13951718
17regulation of natural killer cell differentiation (GO:0032823)5.00723654
18phosphatidylinositol acyl-chain remodeling (GO:0036149)4.82965755
19linoleic acid metabolic process (GO:0043651)4.75740114
20phosphatidylserine acyl-chain remodeling (GO:0036150)4.72164351
21negative regulation of interleukin-17 production (GO:0032700)4.67826370
22water homeostasis (GO:0030104)4.66074799
23negative regulation of interferon-gamma production (GO:0032689)4.65275422
24regulation of vitamin metabolic process (GO:0030656)4.31757499
25skin morphogenesis (GO:0043589)4.24124882
26regulation of chemokine biosynthetic process (GO:0045073)4.15390903
27regulation of fever generation (GO:0031620)4.13609654
28response to peptidoglycan (GO:0032494)4.13594434
29regulation of monocyte chemotaxis (GO:0090025)4.05736680
30positive regulation of heat generation (GO:0031652)4.02999106
31gap junction assembly (GO:0016264)3.93332868
32positive regulation of chemokine biosynthetic process (GO:0045080)3.92961574
33sequestering of metal ion (GO:0051238)3.91342783
34detection of external biotic stimulus (GO:0098581)3.82193744
35phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.81755382
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.76194467
37phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.70375313
38regulation of podosome assembly (GO:0071801)3.68243441
39positive regulation of T cell chemotaxis (GO:0010820)3.65905442
40regulation of T cell chemotaxis (GO:0010819)3.65905442
41phosphatidylcholine acyl-chain remodeling (GO:0036151)3.54463808
42positive regulation of cellular amide metabolic process (GO:0034250)3.53721579
43positive regulation of p38MAPK cascade (GO:1900745)3.52041198
44positive regulation of type 2 immune response (GO:0002830)3.50917025
45regulation of chronic inflammatory response (GO:0002676)3.47104370
46negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.44909153
47regulation of lymphocyte chemotaxis (GO:1901623)3.44367406
48activation of MAPKKK activity (GO:0000185)3.41860139
49detection of biotic stimulus (GO:0009595)3.36499473
50branching involved in labyrinthine layer morphogenesis (GO:0060670)3.35933781
51regulation of natural killer cell activation (GO:0032814)3.35880111
52regulation of cytokine secretion involved in immune response (GO:0002739)3.34697043
53regulation of T-helper 1 cell differentiation (GO:0045625)3.31793478
54defense response to Gram-negative bacterium (GO:0050829)3.30686669
55phospholipid efflux (GO:0033700)3.28360340
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.25952837
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24688387
58positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.23855417
59regulation of immunoglobulin secretion (GO:0051023)3.22976985
60negative regulation of interleukin-12 production (GO:0032695)3.22156271
61regulation of interleukin-17 production (GO:0032660)3.20291702
62positive regulation of granulocyte chemotaxis (GO:0071624)3.15087717
63intermediate filament organization (GO:0045109)3.12687496
64regulation of heat generation (GO:0031650)3.11593709
65positive regulation of epidermis development (GO:0045684)3.08617753
66regulation of transforming growth factor beta1 production (GO:0032908)3.03382379
67regulation of membrane protein ectodomain proteolysis (GO:0051043)3.02171866
68phosphatidylserine metabolic process (GO:0006658)3.01918923
69regulation of T-helper 2 cell differentiation (GO:0045628)3.01322826
70surfactant homeostasis (GO:0043129)2.95868159
71* positive regulation of interleukin-6 production (GO:0032755)2.93626664
72intermediate filament cytoskeleton organization (GO:0045104)2.93272506
73positive regulation of hair cycle (GO:0042635)2.92958443
74positive regulation of hair follicle development (GO:0051798)2.92958443
75cellular response to arsenic-containing substance (GO:0071243)2.90272243
76negative regulation of lipid storage (GO:0010888)2.89674235
77hemidesmosome assembly (GO:0031581)2.88593311
78negative regulation of cytokine secretion (GO:0050710)2.85913749
79ectoderm development (GO:0007398)2.84908377
80* regulation of interleukin-6 production (GO:0032675)2.84647533
81intermediate filament-based process (GO:0045103)2.82090575
82positive regulation of humoral immune response (GO:0002922)2.81446945
83negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80036284
84regulation of heterotypic cell-cell adhesion (GO:0034114)2.76403806
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74953086
86negative regulation of interleukin-6 production (GO:0032715)2.74940359
87negative regulation of nitric oxide biosynthetic process (GO:0045019)2.72669448
88cellular response to type I interferon (GO:0071357)2.72411187
89type I interferon signaling pathway (GO:0060337)2.72411187
90regulation of nitric oxide biosynthetic process (GO:0045428)2.70944730
91positive regulation of nitric oxide biosynthetic process (GO:0045429)2.70361175
92regulation of mononuclear cell migration (GO:0071675)2.69676971
93response to type I interferon (GO:0034340)2.67158424
94macrophage activation involved in immune response (GO:0002281)2.67155063
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65872934
96leukocyte aggregation (GO:0070486)2.64847503
97positive regulation of cholesterol efflux (GO:0010875)2.61504363
98response to protozoan (GO:0001562)2.61328712
99keratinization (GO:0031424)15.3346076
100establishment of skin barrier (GO:0061436)10.1759274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.70084689
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.41914992
3RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.70147378
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.09765185
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.01264349
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.69132053
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.63817747
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.31809662
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.31809662
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26608694
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.17265128
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14757248
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14548083
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12770199
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12687079
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.09570632
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03536276
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99773511
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.84329293
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79671531
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.78047462
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.69518277
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67437956
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63815512
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62734702
26SOX2_20726797_ChIP-Seq_SW620_Human1.60206706
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59252545
28EGR1_19032775_ChIP-ChIP_M12_Human1.57103264
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.55905179
30TP63_23658742_ChIP-Seq_EP156T_Human1.54373245
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47616834
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46126773
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43134910
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41695722
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.41447891
36ATF3_27146783_Chip-Seq_COLON_Human1.38069408
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36942618
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35963414
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33111056
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.31880590
41VDR_24787735_ChIP-Seq_THP-1_Human1.28232858
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27440244
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25595686
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23560824
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22665166
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22516430
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.22122066
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.20643485
49FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20494950
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20197427
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18924688
52TP63_22573176_ChIP-Seq_HFKS_Human1.15777460
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15127914
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14565530
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13530775
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.13278700
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.09754893
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09215491
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09133741
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07263129
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04418576
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04400162
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03734441
64CJUN_26792858_Chip-Seq_BT549_Human1.03548377
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02223774
66RACK7_27058665_Chip-Seq_MCF-7_Human1.02071201
67CLOCK_20551151_ChIP-Seq_293T_Human0.99908161
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95408248
69GATA1_22025678_ChIP-Seq_K562_Human0.94954966
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93588363
71DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92721291
72ZNF263_19887448_ChIP-Seq_K562_Human0.91779595
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90974546
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90822734
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.90619979
76RXR_22108803_ChIP-Seq_LS180_Human0.90479352
77KLF5_25053715_ChIP-Seq_YYC3_Human0.89650750
78LXR_22292898_ChIP-Seq_THP-1_Human0.89640336
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89158040
80BCOR_27268052_Chip-Seq_Bcells_Human0.88526067
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87874564
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86417685
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86115664
84GATA1_19941826_ChIP-Seq_K562_Human0.85627306
85ERG_20517297_ChIP-Seq_VCAP_Human0.84165090
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82015294
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81984923
88PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78193351
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77465301
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.76953916
91PU_27001747_Chip-Seq_BMDM_Mouse0.76575153
92TP53_18474530_ChIP-ChIP_U2OS_Human0.76213788
93RXR_22158963_ChIP-Seq_LIVER_Mouse0.75087726
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74737167
95RUNX1_27514584_Chip-Seq_MCF-7_Human0.74338947
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.74111253
97VDR_24763502_ChIP-Seq_THP-1_Human0.73873956
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73008737
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72425298
100GATA2_19941826_ChIP-Seq_K562_Human0.71970360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.68569979
2MP0000579_abnormal_nail_morphology5.35292006
3MP0005275_abnormal_skin_tensile4.98425935
4MP0010234_abnormal_vibrissa_follicle4.33760820
5MP0005501_abnormal_skin_physiology4.22765313
6MP0003453_abnormal_keratinocyte_physiol3.94605131
7MP0003303_peritoneal_inflammation3.23961793
8MP0001216_abnormal_epidermal_layer2.95785115
9MP0004947_skin_inflammation2.95504273
10MP0003941_abnormal_skin_development2.80007136
11MP0009840_abnormal_foam_cell2.46282635
12MP0003191_abnormal_cellular_cholesterol2.43045759
13MP0005377_hearing/vestibular/ear_phenot2.35800896
14MP0003878_abnormal_ear_physiology2.35800896
15MP0006082_CNS_inflammation2.30092632
16MP0010678_abnormal_skin_adnexa2.28608903
17MP0010771_integument_phenotype2.23326018
18MP0002060_abnormal_skin_morphology2.21561396
19MP0004885_abnormal_endolymph2.11824115
20MP0009785_altered_susceptibility_to2.10761926
21MP0002148_abnormal_hypersensitivity_rea2.04432715
22MP0008004_abnormal_stomach_pH1.99909615
23MP0003436_decreased_susceptibility_to1.92768680
24MP0000383_abnormal_hair_follicle1.87316190
25MP0004510_myositis1.82435154
26MP0004264_abnormal_extraembryonic_tissu1.65829337
27MP0003705_abnormal_hypodermis_morpholog1.60897923
28MP0004381_abnormal_hair_follicle1.56374117
29MP0000467_abnormal_esophagus_morphology1.54815578
30MP0002098_abnormal_vibrissa_morphology1.48981671
31MP0010352_gastrointestinal_tract_polyps1.47805626
32MP0003724_increased_susceptibility_to1.46243468
33MP0005000_abnormal_immune_tolerance1.42995834
34MP0009931_abnormal_skin_appearance1.42363860
35MP0005387_immune_system_phenotype1.40225012
36MP0001790_abnormal_immune_system1.40225012
37MP0003950_abnormal_plasma_membrane1.32736357
38MP0000377_abnormal_hair_follicle1.30416350
39MP0005023_abnormal_wound_healing1.30346972
40MP0009764_decreased_sensitivity_to1.30022501
41MP0005025_abnormal_response_to1.27715694
42MP0001191_abnormal_skin_condition1.27347980
43MP0003300_gastrointestinal_ulcer1.25224601
44MP0002254_reproductive_system_inflammat1.20828144
45MP0005671_abnormal_response_to1.12973755
46MP0003075_altered_response_to1.12714375
47MP0005058_abnormal_lysosome_morphology1.11050213
48MP0002419_abnormal_innate_immunity1.10853642
49MP0002332_abnormal_exercise_endurance1.08949720
50MP0001533_abnormal_skeleton_physiology1.08393705
51MP0001188_hyperpigmentation1.08004681
52MP0000858_altered_metastatic_potential1.06328359
53MP0000762_abnormal_tongue_morphology1.02718725
54MP0004782_abnormal_surfactant_physiolog1.02130820
55MP0003448_altered_tumor_morphology1.01968435
56MP0001851_eye_inflammation1.01177974
57MP0000465_gastrointestinal_hemorrhage1.00883912
58MP0001800_abnormal_humoral_immune1.00260592
59MP0001835_abnormal_antigen_presentation1.00091773
60MP0010155_abnormal_intestine_physiology0.99631981
61MP0000343_altered_response_to0.99621752
62MP0003566_abnormal_cell_adhesion0.97980905
63MP0002452_abnormal_antigen_presenting0.97375027
64MP0002723_abnormal_immune_serum0.97129362
65MP0000367_abnormal_coat/_hair0.97033226
66MP0000685_abnormal_immune_system0.93747231
67MP0005409_darkened_coat_color0.93605723
68MP0005166_decreased_susceptibility_to0.91001599
69MP0009333_abnormal_splenocyte_physiolog0.85779948
70MP0001853_heart_inflammation0.83925255
71MP0001845_abnormal_inflammatory_respons0.82708552
72MP0000647_abnormal_sebaceous_gland0.81958954
73MP0002998_abnormal_bone_remodeling0.81902646
74MP0002139_abnormal_hepatobiliary_system0.80660785
75MP0005167_abnormal_blood-brain_barrier0.80300961
76MP0008469_abnormal_protein_level0.75620910
77MP0002877_abnormal_melanocyte_morpholog0.74429523
78MP0005451_abnormal_body_composition0.73410919
79MP0005164_abnormal_response_to0.72463661
80MP0000427_abnormal_hair_cycle0.72085905
81MP0003690_abnormal_glial_cell0.71887432
82MP0002006_tumorigenesis0.70298965
83MP0004185_abnormal_adipocyte_glucose0.68376987
84MP0003806_abnormal_nucleotide_metabolis0.67716089
85MP0001243_abnormal_dermal_layer0.67661365
86MP0001819_abnormal_immune_cell0.66535749
87MP0002420_abnormal_adaptive_immunity0.65185674
88MP0000566_synostosis0.62479971
89MP0002138_abnormal_hepatobiliary_system0.61931574
90MP0002095_abnormal_skin_pigmentation0.60104771
91MP0003656_abnormal_erythrocyte_physiolo0.59783161
92MP0000604_amyloidosis0.58540011
93MP0001501_abnormal_sleep_pattern0.58302465
94MP0002405_respiratory_system_inflammati0.57166222
95MP0009278_abnormal_bone_marrow0.57090399
96MP0006054_spinal_hemorrhage0.55630652
97MP0001545_abnormal_hematopoietic_system0.54694184
98MP0005397_hematopoietic_system_phenotyp0.54694184
99MP0004043_abnormal_pH_regulation0.52872302
100MP0009765_abnormal_xenobiotic_induced0.51970457

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)8.19679748
2Palmar hyperkeratosis (HP:0010765)7.75509754
3Erythroderma (HP:0001019)7.65741298
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.59645971
5Oral leukoplakia (HP:0002745)7.52740640
6Increased IgE level (HP:0003212)7.49294325
7Congenital ichthyosiform erythroderma (HP:0007431)7.01253489
8Parakeratosis (HP:0001036)6.81021456
9Plantar hyperkeratosis (HP:0007556)6.75776494
10Alopecia of scalp (HP:0002293)6.13926303
11Thick nail (HP:0001805)6.06973628
12Onycholysis (HP:0001806)5.72192175
13Corneal erosion (HP:0200020)5.33692789
14Erythema (HP:0010783)5.28687437
15Gangrene (HP:0100758)5.08414585
16Ectropion (HP:0000656)4.38424754
17Abnormality of the axillary hair (HP:0100134)4.37339727
18Abnormality of secondary sexual hair (HP:0009888)4.37339727
19Hypotrichosis (HP:0001006)4.25833399
20Hypohidrosis (HP:0000966)4.24240701
21Nail dystrophy (HP:0008404)3.87526679
22Palmoplantar keratoderma (HP:0000982)3.81581421
23Conjunctival hamartoma (HP:0100780)3.71847297
24Pustule (HP:0200039)3.64471161
25Abnormality of placental membranes (HP:0011409)3.40275628
26Amniotic constriction ring (HP:0009775)3.40275628
27Follicular hyperkeratosis (HP:0007502)3.26811229
28Keratoconjunctivitis sicca (HP:0001097)3.24958052
29Abnormal blistering of the skin (HP:0008066)3.20553686
30Recurrent bacterial skin infections (HP:0005406)3.18573512
31Right ventricular cardiomyopathy (HP:0011663)3.04245267
32Sparse eyelashes (HP:0000653)3.03423638
33Absent eyelashes (HP:0000561)3.02181670
34Lip pit (HP:0100267)2.96597941
35Keratoconjunctivitis (HP:0001096)2.95797812
36Pruritus (HP:0000989)2.91709948
37Absent hair (HP:0002298)2.83934590
38Abnormality of glycolipid metabolism (HP:0010969)2.75310191
39Abnormality of liposaccharide metabolism (HP:0010968)2.75310191
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.75310191
41Fragile nails (HP:0001808)2.69010073
42Abnormality of the salivary glands (HP:0010286)2.67060544
43Furrowed tongue (HP:0000221)2.65587025
44Urticaria (HP:0001025)2.60900096
45Hypergammaglobulinemia (HP:0010702)2.58022964
46Woolly hair (HP:0002224)2.55175900
47Paralysis (HP:0003470)2.51446750
48Eczematoid dermatitis (HP:0000976)2.48187737
49Autoamputation (HP:0001218)2.41922865
50Lack of skin elasticity (HP:0100679)2.37097408
51Multifactorial inheritance (HP:0001426)2.32466598
52Recurrent corneal erosions (HP:0000495)2.28493165
53Dehydration (HP:0001944)2.25240622
54Hamartoma of the eye (HP:0010568)2.21913553
55Blepharitis (HP:0000498)2.20660589
56Ridged nail (HP:0001807)2.14591813
57Hyperhidrosis (HP:0000975)2.12144019
58Sparse scalp hair (HP:0002209)2.07333523
59Axonal loss (HP:0003447)2.06776546
60Milia (HP:0001056)2.05230456
61Sepsis (HP:0100806)2.02026219
62Xerostomia (HP:0000217)2.00692318
63Malnutrition (HP:0004395)2.00189138
64Abnormality of nail color (HP:0100643)12.3136666
65Corneal dystrophy (HP:0001131)1.97234660
66Abnormality of macrophages (HP:0004311)1.96256928
67Orchitis (HP:0100796)1.92851984
68Skin ulcer (HP:0200042)1.92417310
69Optic neuritis (HP:0100653)1.91544562
70Retrobulbar optic neuritis (HP:0100654)1.91544562
71Vacuolated lymphocytes (HP:0001922)1.84887506
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84291618
73Laryngomalacia (HP:0001601)1.81727441
74Dry skin (HP:0000958)1.76832066
75Recurrent skin infections (HP:0001581)1.75828157
76Carious teeth (HP:0000670)1.74612695
77Natal tooth (HP:0000695)1.73915172
78Pili torti (HP:0003777)1.70772046
79Abnormal hair laboratory examination (HP:0003328)1.70030156
80Mediastinal lymphadenopathy (HP:0100721)1.63138636
81Anonychia (HP:0001798)1.59260366
82Systemic lupus erythematosus (HP:0002725)1.58174517
83Myositis (HP:0100614)1.53382271
84Melanocytic nevus (HP:0000995)1.52515891
85Autoimmune thrombocytopenia (HP:0001973)1.52326722
86Dysostosis multiplex (HP:0000943)1.46671626
87Disinhibition (HP:0000734)1.46541033
88Abnormality of the fingernails (HP:0001231)1.41522856
89Increased cerebral lipofuscin (HP:0011813)1.41237406
90Dry hair (HP:0011359)1.40296445
91Keratitis (HP:0000491)1.38615796
92Papilloma (HP:0012740)1.38504344
93Verrucae (HP:0200043)1.38504344
94Loss of speech (HP:0002371)1.37970099
95Segmental peripheral demyelination/remyelination (HP:0003481)1.35269578
96Neurofibrillary tangles (HP:0002185)1.35145137
97Hypoplastic labia majora (HP:0000059)1.34872519
98Advanced eruption of teeth (HP:0006288)1.33265258
99Brittle hair (HP:0002299)1.32808819
100Conical tooth (HP:0000698)1.30083922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.72603066
2GRK73.01593686
3MAP3K92.95048582
4EPHA22.93569012
5MAP3K142.80386171
6NME22.73410721
7DDR22.62811790
8RIPK12.56355492
9MAP3K32.46982022
10TAOK22.44154003
11IKBKB2.43155154
12MATK2.30304623
13TGFBR12.19479430
14LATS22.16429245
15TBK12.14275445
16STK242.13417956
17IKBKE2.05402868
18TAOK12.03800415
19IRAK42.02235935
20BMPR21.97614710
21MOS1.85471947
22PRPF4B1.85225088
23IRAK11.75977964
24PIM21.71858796
25FGR1.70231166
26MAP3K61.66733304
27BLK1.66092363
28EPHA31.54889800
29ERN11.47875357
30IRAK21.42722547
31FER1.39034317
32TYK21.37881578
33MAP3K131.36644504
34JAK31.26628197
35ADRBK21.24613892
36CDC42BPA1.23691106
37MUSK1.23194714
38CSK1.22190626
39TGFBR21.22061200
40CHUK1.18999432
41MST41.16783706
42ABL21.14103789
43MAP3K111.13983518
44MAP3K11.11134933
45TYRO31.01275449
46ARAF1.00782043
47FGFR30.95368091
48PDGFRA0.94909875
49EPHB20.94405393
50JAK10.93788215
51EPHB10.87650461
52BMX0.85751508
53MAP2K60.85557433
54SIK30.83496387
55TXK0.82073459
56RIPK40.81976780
57FGFR40.78086290
58MST1R0.78013608
59PIK3CG0.76717501
60DYRK30.74422079
61STK100.73607088
62MAP3K20.72530713
63PKN10.71554064
64MAP3K50.70301341
65MAPK70.64458334
66ACVR1B0.59065638
67PBK0.58753609
68ZAP700.57723963
69MAP4K10.51690565
70PDGFRB0.50399176
71FGFR10.49833046
72JAK20.49087388
73SIK10.48299227
74CDK60.44968082
75MAP3K120.44717728
76MAP2K30.44461988
77SGK2230.42638195
78SGK4940.42638195
79MARK30.40545188
80GSK3A0.36230683
81HIPK20.36214311
82KIT0.36206304
83MAPK40.36153479
84LYN0.34548835
85MAPKAPK30.33952463
86MAPKAPK20.33922089
87PIM10.33621092
88TESK20.32779568
89ABL10.32035282
90HCK0.30916650
91DMPK0.30916630
92TAOK30.29411315
93SYK0.27925818
94GRK60.27519401
95PRKCD0.18584016
96EGFR0.18330531
97NLK0.18198424
98MARK20.18143551
99LCK0.15393646
100INSR0.14520342

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.98997185
2Linoleic acid metabolism_Homo sapiens_hsa005912.99704739
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.91708912
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.76568555
5Rheumatoid arthritis_Homo sapiens_hsa053232.50064015
6Pertussis_Homo sapiens_hsa051332.39544622
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35373850
8Ether lipid metabolism_Homo sapiens_hsa005652.31405339
9TNF signaling pathway_Homo sapiens_hsa046682.23383936
10Legionellosis_Homo sapiens_hsa051342.22145467
11Malaria_Homo sapiens_hsa051442.18304504
12Staphylococcus aureus infection_Homo sapiens_hsa051502.14810835
13African trypanosomiasis_Homo sapiens_hsa051432.12421032
14Graft-versus-host disease_Homo sapiens_hsa053322.11666699
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.09525678
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08605557
17Arachidonic acid metabolism_Homo sapiens_hsa005902.04559805
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95097695
19Salmonella infection_Homo sapiens_hsa051321.89957934
20Amoebiasis_Homo sapiens_hsa051461.88801268
21Leishmaniasis_Homo sapiens_hsa051401.83241550
22Sphingolipid metabolism_Homo sapiens_hsa006001.77172733
23Osteoclast differentiation_Homo sapiens_hsa043801.76520443
24Allograft rejection_Homo sapiens_hsa053301.68654228
25Influenza A_Homo sapiens_hsa051641.62780731
26Tuberculosis_Homo sapiens_hsa051521.59535012
27VEGF signaling pathway_Homo sapiens_hsa043701.57357892
28Asthma_Homo sapiens_hsa053101.53787924
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53455510
30Prion diseases_Homo sapiens_hsa050201.48417093
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45580492
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39860574
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35285144
34Other glycan degradation_Homo sapiens_hsa005111.33398157
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.32165225
36Type I diabetes mellitus_Homo sapiens_hsa049401.31215926
37GnRH signaling pathway_Homo sapiens_hsa049121.26567937
38Toxoplasmosis_Homo sapiens_hsa051451.19996111
39Lysosome_Homo sapiens_hsa041421.19156608
40Autoimmune thyroid disease_Homo sapiens_hsa053201.16753215
41Ovarian steroidogenesis_Homo sapiens_hsa049131.13250817
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10379756
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08862965
44Bladder cancer_Homo sapiens_hsa052191.08542407
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08347822
46Hepatitis C_Homo sapiens_hsa051601.05524261
47Hematopoietic cell lineage_Homo sapiens_hsa046401.04192050
48Measles_Homo sapiens_hsa051621.02569684
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00848276
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.98394260
51Herpes simplex infection_Homo sapiens_hsa051680.94829746
52Shigellosis_Homo sapiens_hsa051310.92083302
53Chemokine signaling pathway_Homo sapiens_hsa040620.83688572
54Acute myeloid leukemia_Homo sapiens_hsa052210.78766577
55Mineral absorption_Homo sapiens_hsa049780.71749826
56Hepatitis B_Homo sapiens_hsa051610.68536765
57Galactose metabolism_Homo sapiens_hsa000520.67493764
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.65068845
59Long-term depression_Homo sapiens_hsa047300.64452265
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60071686
61Phagosome_Homo sapiens_hsa041450.59469017
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.59206272
63Antigen processing and presentation_Homo sapiens_hsa046120.58505135
64Apoptosis_Homo sapiens_hsa042100.55804292
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.52560832
66Viral myocarditis_Homo sapiens_hsa054160.52145445
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.51556310
68Complement and coagulation cascades_Homo sapiens_hsa046100.51246396
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49893334
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.49163555
71HIF-1 signaling pathway_Homo sapiens_hsa040660.48939214
72B cell receptor signaling pathway_Homo sapiens_hsa046620.44407069
73MAPK signaling pathway_Homo sapiens_hsa040100.44254201
74Platelet activation_Homo sapiens_hsa046110.44004036
75Ras signaling pathway_Homo sapiens_hsa040140.41610188
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41303274
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.40137265
78Choline metabolism in cancer_Homo sapiens_hsa052310.40038223
79Collecting duct acid secretion_Homo sapiens_hsa049660.39003861
80Prolactin signaling pathway_Homo sapiens_hsa049170.37839195
81Serotonergic synapse_Homo sapiens_hsa047260.37356415
82T cell receptor signaling pathway_Homo sapiens_hsa046600.36587779
83Type II diabetes mellitus_Homo sapiens_hsa049300.34595003
84Renal cell carcinoma_Homo sapiens_hsa052110.33757916
85Fructose and mannose metabolism_Homo sapiens_hsa000510.33757470
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33744071
87Dorso-ventral axis formation_Homo sapiens_hsa043200.33289889
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.32867418
89PPAR signaling pathway_Homo sapiens_hsa033200.30779176
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29361080
91p53 signaling pathway_Homo sapiens_hsa041150.28784941
92Histidine metabolism_Homo sapiens_hsa003400.27745716
93Fat digestion and absorption_Homo sapiens_hsa049750.27731294
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27361653
95Epstein-Barr virus infection_Homo sapiens_hsa051690.26565517
96Sulfur metabolism_Homo sapiens_hsa009200.26329818
97Pancreatic cancer_Homo sapiens_hsa052120.22136712
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21228358
99Circadian rhythm_Homo sapiens_hsa047100.20290554
100Endocytosis_Homo sapiens_hsa041440.19392218

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