IL36RN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.79699818
2multicellular organismal water homeostasis (GO:0050891)9.20346520
3long-chain fatty acid biosynthetic process (GO:0042759)8.41796489
4epidermis development (GO:0008544)7.83116052
5water homeostasis (GO:0030104)7.73530614
6lipoxygenase pathway (GO:0019372)7.50145583
7molting cycle (GO:0042303)7.43643016
8hair cycle (GO:0042633)7.43643016
9detection of bacterium (GO:0016045)7.26440831
10keratinocyte proliferation (GO:0043616)7.23402873
11linoleic acid metabolic process (GO:0043651)7.04288156
12detection of other organism (GO:0098543)6.73508332
13bundle of His cell to Purkinje myocyte communication (GO:0086069)6.24175487
14phosphatidylinositol acyl-chain remodeling (GO:0036149)6.17631716
15phosphatidylserine acyl-chain remodeling (GO:0036150)6.10562063
16skin morphogenesis (GO:0043589)5.83523128
17regulation of natural killer cell differentiation (GO:0032823)5.64851246
18positive regulation of monocyte chemotaxis (GO:0090026)5.07591086
19phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.98911174
20phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.80237764
21gap junction assembly (GO:0016264)4.67087223
22ectoderm development (GO:0007398)4.47858231
23phosphatidylcholine acyl-chain remodeling (GO:0036151)4.43456602
24intermediate filament organization (GO:0045109)4.41333293
25intermediate filament cytoskeleton organization (GO:0045104)4.32290890
26sequestering of metal ion (GO:0051238)4.25759004
27positive regulation of T cell chemotaxis (GO:0010820)4.23440671
28regulation of T cell chemotaxis (GO:0010819)4.23440671
29intermediate filament-based process (GO:0045103)4.17301637
30surfactant homeostasis (GO:0043129)4.13746896
31detection of external biotic stimulus (GO:0098581)4.03100811
32phosphatidylserine metabolic process (GO:0006658)3.84332763
33positive regulation of cellular amide metabolic process (GO:0034250)3.77522511
34regulation of monocyte chemotaxis (GO:0090025)3.69175006
35* negative regulation of interferon-gamma production (GO:0032689)3.65211772
36establishment of planar polarity (GO:0001736)3.64028092
37establishment of tissue polarity (GO:0007164)3.64028092
38epithelium development (GO:0060429)3.59522652
39defense response to Gram-negative bacterium (GO:0050829)3.53658732
40chemical homeostasis within a tissue (GO:0048875)3.53637404
41hemidesmosome assembly (GO:0031581)3.48458297
42keratinocyte development (GO:0003334)3.47503376
43detection of biotic stimulus (GO:0009595)3.45826880
44positive regulation of epidermis development (GO:0045684)3.38445836
45ceramide biosynthetic process (GO:0046513)3.34026356
46regulation of natural killer cell activation (GO:0032814)3.28838444
47regulation of transforming growth factor beta1 production (GO:0032908)3.22244370
48positive regulation of p38MAPK cascade (GO:1900745)3.20141603
49alditol phosphate metabolic process (GO:0052646)3.13497415
50phospholipid catabolic process (GO:0009395)3.13357495
51positive regulation of cholesterol efflux (GO:0010875)3.11219010
52regulation of lymphocyte chemotaxis (GO:1901623)3.01547890
53keratinization (GO:0031424)26.0623845
54phospholipid efflux (GO:0033700)2.90872696
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87437726
56epithelial cell differentiation (GO:0030855)2.87317281
57eyelid development in camera-type eye (GO:0061029)2.82849395
58positive regulation of epidermal cell differentiation (GO:0045606)2.81709220
59regulation of neuron projection regeneration (GO:0070570)2.80543406
60regulation of axon regeneration (GO:0048679)2.80543406
61positive regulation of cholesterol transport (GO:0032376)2.69918709
62positive regulation of sterol transport (GO:0032373)2.69918709
63positive regulation of granulocyte chemotaxis (GO:0071624)2.69209929
64hair cell differentiation (GO:0035315)2.64784846
65positive regulation of glomerulus development (GO:0090193)2.63627103
66regulation of keratinocyte differentiation (GO:0045616)2.62021491
67cellular response to arsenic-containing substance (GO:0071243)2.61536123
68planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61035822
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59303546
70hair follicle morphogenesis (GO:0031069)2.56263300
71regulation of T cell migration (GO:2000404)2.55742202
72regulation of epidermis development (GO:0045682)2.53761890
73positive regulation of interleukin-6 production (GO:0032755)2.52828831
74negative regulation of keratinocyte proliferation (GO:0010839)2.52324409
75regulation of cholesterol homeostasis (GO:2000188)2.51851511
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49470618
77fatty acid elongation (GO:0030497)2.47405930
78phosphatidylglycerol metabolic process (GO:0046471)2.46574186
79positive regulation of keratinocyte differentiation (GO:0045618)2.45768459
80polarized epithelial cell differentiation (GO:0030859)2.43057369
81intestinal epithelial cell development (GO:0060576)2.38545666
82regulation of p38MAPK cascade (GO:1900744)2.37279572
83defense response to Gram-positive bacterium (GO:0050830)2.34281462
84regulation of protein localization to cell surface (GO:2000008)2.33658510
85sphingolipid biosynthetic process (GO:0030148)2.33452706
86lateral sprouting from an epithelium (GO:0060601)2.33183422
87ventricular cardiac muscle cell action potential (GO:0086005)2.28895712
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.24956388
89positive regulation of T cell migration (GO:2000406)2.23351780
90positive regulation of humoral immune response (GO:0002922)2.21193019
91phosphatidic acid biosynthetic process (GO:0006654)2.20687280
92phosphatidic acid metabolic process (GO:0046473)2.20687280
93positive regulation of chemokine biosynthetic process (GO:0045080)2.14229772
94regulation of epidermal cell differentiation (GO:0045604)2.09385489
95regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07448204
96establishment of skin barrier (GO:0061436)16.6603179
97regulation of water loss via skin (GO:0033561)14.3506323
98keratinocyte differentiation (GO:0030216)13.2437511
99epidermal cell differentiation (GO:0009913)10.3867734
100peptide cross-linking (GO:0018149)10.1945486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.04162636
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.87390862
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36926043
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.36355408
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.64444594
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.64444594
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.36888731
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.29290963
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.28070284
10SOX9_24532713_ChIP-Seq_HFSC_Mouse2.25788037
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.23534315
12TP63_17297297_ChIP-ChIP_HaCaT_Human10.6978222
13TP63_23658742_ChIP-Seq_EP156T_Human1.99554927
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87115530
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83821213
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81867855
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.81659567
18GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.76959483
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76857450
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73737971
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67245541
22RXR_22108803_ChIP-Seq_LS180_Human1.65557188
23SOX2_20726797_ChIP-Seq_SW620_Human1.61745985
24KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55904116
25TP63_22573176_ChIP-Seq_HFKS_Human1.54842734
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.49667075
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.47824427
28ATF3_27146783_Chip-Seq_COLON_Human1.44406570
29CJUN_26792858_Chip-Seq_BT549_Human1.39161384
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38492666
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.36170561
32ERG_20517297_ChIP-Seq_VCAP_Human1.35950298
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35565881
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33101695
35KLF5_25053715_ChIP-Seq_YYC3_Human1.32671764
36FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32377761
37EGR1_19032775_ChIP-ChIP_M12_Human1.30893837
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29268170
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27180737
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25333128
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24308061
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.23671032
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21812965
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20715531
45JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17690461
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14077010
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10839031
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09605627
49AHR_22903824_ChIP-Seq_MCF-7_Human1.09365838
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.08977992
51RACK7_27058665_Chip-Seq_MCF-7_Human1.05531178
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.02075512
53CTCF_27219007_Chip-Seq_Bcells_Human1.00975359
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00377901
55FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98951768
56GATA4_25053715_ChIP-Seq_YYC3_Human0.98586800
57TP53_18474530_ChIP-ChIP_U2OS_Human0.97606269
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96137936
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91687336
60SMC4_20622854_ChIP-Seq_HELA_Human0.91351601
61GATA6_25053715_ChIP-Seq_YYC3_Human0.87292340
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87138316
63NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86179995
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86179995
65MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84934893
66CTCF_20526341_ChIP-Seq_ESCs_Human0.83376070
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83309744
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82599753
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82155940
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81637175
71ZNF263_19887448_ChIP-Seq_K562_Human0.80937889
72GATA2_21666600_ChIP-Seq_HMVEC_Human0.80620904
73CLOCK_20551151_ChIP-Seq_293T_Human0.79769209
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79343693
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78930903
76RBPJ_21746931_ChIP-Seq_IB4_Human0.78755135
77IRF8_27001747_Chip-Seq_BMDM_Mouse0.78461471
78GATA2_19941826_ChIP-Seq_K562_Human0.77929928
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77783438
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.76873475
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76088213
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76003572
83E2F1_20622854_ChIP-Seq_HELA_Human0.75797710
84BCOR_27268052_Chip-Seq_Bcells_Human0.75415953
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73315776
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.73109419
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.72995838
88TP53_16413492_ChIP-PET_HCT116_Human0.71668142
89SMAD_19615063_ChIP-ChIP_OVARY_Human0.71586971
90HNFA_21074721_ChIP-Seq_CACO-2_Human0.69872390
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69722261
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69551416
93PPARA_22158963_ChIP-Seq_LIVER_Mouse0.68636110
94GATA1_19941826_ChIP-Seq_K562_Human0.67633394
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.66605242
96TBX20_22080862_ChIP-Seq_HEART_Mouse0.66138092
97TBX20_22328084_ChIP-Seq_HEART_Mouse0.66138092
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.65691517
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.64746398
100CEBPB_22108803_ChIP-Seq_LS180_Human0.64616979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.64101652
2MP0005275_abnormal_skin_tensile7.26077793
3MP0010234_abnormal_vibrissa_follicle6.82276138
4MP0005501_abnormal_skin_physiology5.42793729
5MP0000579_abnormal_nail_morphology5.02946188
6MP0003453_abnormal_keratinocyte_physiol3.45194024
7MP0003941_abnormal_skin_development3.39130012
8MP0001216_abnormal_epidermal_layer3.16984874
9MP0010678_abnormal_skin_adnexa3.02830170
10MP0010771_integument_phenotype2.79328859
11MP0004947_skin_inflammation2.60718935
12MP0003191_abnormal_cellular_cholesterol2.58916985
13MP0002060_abnormal_skin_morphology2.57001897
14MP0005377_hearing/vestibular/ear_phenot2.42555148
15MP0003878_abnormal_ear_physiology2.42555148
16MP0000383_abnormal_hair_follicle2.30734370
17MP0004885_abnormal_endolymph2.29876069
18MP0002098_abnormal_vibrissa_morphology2.13018600
19MP0000377_abnormal_hair_follicle2.01275645
20MP0004381_abnormal_hair_follicle1.99392588
21MP0003705_abnormal_hypodermis_morpholog1.96406744
22MP0000467_abnormal_esophagus_morphology1.92157988
23MP0010352_gastrointestinal_tract_polyps1.84673665
24MP0004264_abnormal_extraembryonic_tissu1.69858372
25MP0004782_abnormal_surfactant_physiolog1.65541334
26MP0009931_abnormal_skin_appearance1.60284696
27MP0001188_hyperpigmentation1.59198678
28MP0005409_darkened_coat_color1.51411605
29MP0001191_abnormal_skin_condition1.31939558
30MP0000647_abnormal_sebaceous_gland1.28429368
31MP0000465_gastrointestinal_hemorrhage1.23643446
32MP0000367_abnormal_coat/_hair1.19593397
33MP0003566_abnormal_cell_adhesion1.17235957
34MP0008004_abnormal_stomach_pH1.14219448
35MP0000762_abnormal_tongue_morphology1.14070481
36MP0002095_abnormal_skin_pigmentation1.13111712
37MP0000427_abnormal_hair_cycle1.09496514
38MP0004185_abnormal_adipocyte_glucose1.04598543
39MP0000566_synostosis1.04027767
40MP0005023_abnormal_wound_healing1.02433953
41MP0009379_abnormal_foot_pigmentation1.02179376
42MP0001851_eye_inflammation1.01180939
43MP0003011_delayed_dark_adaptation0.99276027
44MP0004043_abnormal_pH_regulation0.96983612
45MP0003950_abnormal_plasma_membrane0.96867830
46MP0001243_abnormal_dermal_layer0.91351056
47MP0001784_abnormal_fluid_regulation0.81736217
48MP0009053_abnormal_anal_canal0.59426671
49MP0009333_abnormal_splenocyte_physiolog0.58937046
50MP0003303_peritoneal_inflammation0.51128814
51MP0005666_abnormal_adipose_tissue0.47122936
52MP0003300_gastrointestinal_ulcer0.46493624
53MP0005375_adipose_tissue_phenotype0.45240566
54MP0002877_abnormal_melanocyte_morpholog0.43758777
55MP0002138_abnormal_hepatobiliary_system0.43138631
56MP0009840_abnormal_foam_cell0.42329613
57MP0003436_decreased_susceptibility_to0.39097934
58MP0000015_abnormal_ear_pigmentation0.39056991
59MP0002148_abnormal_hypersensitivity_rea0.37990878
60MP0005451_abnormal_body_composition0.36773690
61MP0002177_abnormal_outer_ear0.35805981
62MP0005387_immune_system_phenotype0.33273893
63MP0001790_abnormal_immune_system0.33273893
64MP0004510_myositis0.32226800
65MP0008438_abnormal_cutaneous_collagen0.31928691
66MP0009780_abnormal_chondrocyte_physiolo0.31627960
67MP0005503_abnormal_tendon_morphology0.31262988
68MP0003724_increased_susceptibility_to0.30623133
69MP0001340_abnormal_eyelid_morphology0.28985986
70MP0009785_altered_susceptibility_to0.28917134
71MP0005025_abnormal_response_to0.28395744
72MP0003448_altered_tumor_morphology0.28165275
73MP0000685_abnormal_immune_system0.28050297
74MP0005174_abnormal_tail_pigmentation0.26912425
75MP0002998_abnormal_bone_remodeling0.26290616
76MP0003763_abnormal_thymus_physiology0.25572767
77MP0000627_abnormal_mammary_gland0.25026013
78MP0001533_abnormal_skeleton_physiology0.24581074
79MP0005076_abnormal_cell_differentiation0.23613341
80MP0003075_altered_response_to0.23304766
81MP0003828_pulmonary_edema0.23245193
82MP0000371_diluted_coat_color0.23179206
83MP0005388_respiratory_system_phenotype0.23123607
84MP0002133_abnormal_respiratory_system0.23123607
85MP0002111_abnormal_tail_morphology0.22811907
86MP0001853_heart_inflammation0.22059017
87MP0000003_abnormal_adipose_tissue0.21909806
88MP0003638_abnormal_response/metabolism_0.21825439
89MP0001186_pigmentation_phenotype0.21039060
90MP0010155_abnormal_intestine_physiology0.20194814
91MP0000858_altered_metastatic_potential0.19904397
92MP0001485_abnormal_pinna_reflex0.19804638
93MP0000470_abnormal_stomach_morphology0.19583366
94MP0005166_decreased_susceptibility_to0.19029445
95MP0002006_tumorigenesis0.18921279
96MP0005000_abnormal_immune_tolerance0.18831274
97MP0002234_abnormal_pharynx_morphology0.18629419
98MP0009115_abnormal_fat_cell0.18505045
99MP0004197_abnormal_fetal_growth/weight/0.17992703
100MP0009765_abnormal_xenobiotic_induced0.17942308

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.59473541
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.95347408
3Erythroderma (HP:0001019)8.62372665
4Palmoplantar hyperkeratosis (HP:0000972)8.55570767
5Congenital ichthyosiform erythroderma (HP:0007431)8.47297177
6Palmar hyperkeratosis (HP:0010765)8.13128164
7Oral leukoplakia (HP:0002745)7.37526778
8Plantar hyperkeratosis (HP:0007556)6.94038837
9Onycholysis (HP:0001806)6.33709511
10Alopecia of scalp (HP:0002293)6.04839580
11Thick nail (HP:0001805)5.86112720
12Corneal erosion (HP:0200020)5.68813005
13Hypotrichosis (HP:0001006)5.46044313
14Abnormality of the axillary hair (HP:0100134)5.19356594
15Abnormality of secondary sexual hair (HP:0009888)5.19356594
16* Erythema (HP:0010783)4.96325772
17Ectropion (HP:0000656)4.76168287
18Gangrene (HP:0100758)4.74544791
19Hypohidrosis (HP:0000966)4.35525626
20Palmoplantar keratoderma (HP:0000982)4.19326516
21Conjunctival hamartoma (HP:0100780)4.06763960
22Right ventricular cardiomyopathy (HP:0011663)3.95219942
23Lip pit (HP:0100267)3.79826034
24* Parakeratosis (HP:0001036)3.68647038
25Woolly hair (HP:0002224)3.29827711
26Absent eyelashes (HP:0000561)3.28664449
27Follicular hyperkeratosis (HP:0007502)3.22478032
28* Nail dystrophy (HP:0008404)3.22461977
29Abnormal blistering of the skin (HP:0008066)3.17940950
30Fragile nails (HP:0001808)3.17706106
31Sparse scalp hair (HP:0002209)3.17516268
32Pruritus (HP:0000989)3.09753070
33Sparse eyelashes (HP:0000653)3.08731267
34Absent hair (HP:0002298)3.03719638
35Eczematoid dermatitis (HP:0000976)3.00542358
36Abnormality of the salivary glands (HP:0010286)3.00152370
37Lack of skin elasticity (HP:0100679)2.78624153
38Abnormality of placental membranes (HP:0011409)2.74877338
39Amniotic constriction ring (HP:0009775)2.74877338
40Hamartoma of the eye (HP:0010568)2.68662066
41Hypergammaglobulinemia (HP:0010702)2.67900125
42Dehydration (HP:0001944)2.55310620
43Autoamputation (HP:0001218)2.47411863
44Brittle hair (HP:0002299)2.38836076
45Urticaria (HP:0001025)2.37285505
46Laryngomalacia (HP:0001601)2.27797458
47Blepharitis (HP:0000498)2.25571937
48Natal tooth (HP:0000695)2.15067560
49Keratoconjunctivitis sicca (HP:0001097)2.11888620
50Paralysis (HP:0003470)2.11547672
51Hyperhidrosis (HP:0000975)2.07799857
52Pili torti (HP:0003777)2.01547105
53Abnormality of nail color (HP:0100643)12.8779036
54Melanocytic nevus (HP:0000995)1.96018733
55Multifactorial inheritance (HP:0001426)1.94622184
56Abnormal hair laboratory examination (HP:0003328)1.92619513
57Sepsis (HP:0100806)1.92527241
58Keratoconjunctivitis (HP:0001096)1.90703845
59Milia (HP:0001056)1.89781776
60Advanced eruption of teeth (HP:0006288)1.88017490
61Ridged nail (HP:0001807)1.87341510
62Abnormality of small intestinal villus morphology (HP:0011472)1.84751592
63Villous atrophy (HP:0011473)1.84751592
64Hypoplastic labia majora (HP:0000059)1.84243352
65Recurrent bacterial skin infections (HP:0005406)1.83668996
66Corneal dystrophy (HP:0001131)1.83215548
67Recurrent corneal erosions (HP:0000495)1.82565737
68Dry skin (HP:0000958)1.80784950
69* Furrowed tongue (HP:0000221)1.79622936
70Anonychia (HP:0001798)1.75179717
71Papilloma (HP:0012740)1.74046037
72Verrucae (HP:0200043)1.74046037
73Acanthosis nigricans (HP:0000956)1.73798659
74Skin ulcer (HP:0200042)1.73006078
75Abnormality of hair growth rate (HP:0011363)1.70094899
76Slow-growing hair (HP:0002217)1.70094899
77Abnormality of the labia majora (HP:0012881)1.66251629
78Fine hair (HP:0002213)1.64433056
79Carious teeth (HP:0000670)1.63263780
80Curly hair (HP:0002212)1.60230307
81Selective tooth agenesis (HP:0001592)1.52680464
82Xerostomia (HP:0000217)1.49561549
83Dry hair (HP:0011359)1.48612353
84Abnormality of the fingernails (HP:0001231)1.47403160
85Axonal loss (HP:0003447)1.42958417
86Split foot (HP:0001839)1.39233910
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.37965174
88Hypoplastic toenails (HP:0001800)1.37241872
89Hamartoma (HP:0010566)1.36751175
90* Pustule (HP:0200039)1.31655851
91Duplicated collecting system (HP:0000081)1.31358706
92Recurrent skin infections (HP:0001581)1.29187946
93Oligodontia (HP:0000677)1.28913954
94Anhidrosis (HP:0000970)1.27471462
95Coarse hair (HP:0002208)1.26352686
96Conical tooth (HP:0000698)1.23844330
97Preauricular skin tag (HP:0000384)1.23087270
98Everted lower lip vermilion (HP:0000232)1.21684525
99Abnormality of permanent molar morphology (HP:0011071)1.21223263
100Taurodontia (HP:0000679)1.21223263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.43369832
2STK244.11515278
3MAP3K93.92100420
4TGFBR13.43837746
5FER2.72957192
6IRAK32.67233058
7MAP3K62.59854443
8RIPK12.51101964
9MAP3K32.49886655
10MAP3K22.32917835
11SGK2232.02322328
12SGK4942.02322328
13FGFR11.91477827
14IRAK11.86088693
15EPHA31.85536494
16LATS11.64954742
17TAOK11.61774030
18CDK121.57422386
19IKBKB1.51052395
20ERN11.49106280
21WNK11.46400136
22FGFR31.45062514
23MAP3K11.44156568
24MAPKAPK31.36455019
25EPHB11.31280080
26LATS21.31065727
27TYRO31.30135842
28IRAK21.25925993
29IKBKE1.25701743
30IRAK41.23754981
31TRPM71.21639519
32MST41.17809415
33GRK71.12472714
34DDR21.10450148
35SGK21.10396536
36SGK31.08685630
37MST1R1.06734872
38ABL21.01887400
39PIM21.01111451
40STK31.00454671
41MAPK70.99446667
42MAP2K60.97074137
43STK38L0.94263704
44FGR0.92517727
45TBK10.92130137
46CAMK1D0.92054078
47PDGFRB0.89430321
48CSK0.88292975
49MARK20.85212304
50MET0.84571104
51PRPF4B0.83984496
52TGFBR20.83811428
53MAP3K140.83458823
54BLK0.79820205
55PTK20.79274568
56MOS0.79022779
57PDGFRA0.75918993
58PBK0.74579031
59TAOK20.74335382
60MAP3K120.70283242
61GRK60.70141947
62CDC42BPA0.68916792
63CHUK0.66371262
64MAPKAPK50.62774701
65ERBB30.61579092
66JAK30.61300044
67NLK0.59991716
68BRD40.59608484
69AKT30.59590042
70MTOR0.57075921
71FGFR40.56913362
72CDK60.54890443
73MAP3K50.54300486
74CAMK1G0.53036969
75GSK3A0.51995646
76STK380.50766772
77BMX0.50499394
78RPS6KB10.50179470
79PRKAA20.49464647
80LRRK20.49188073
81MATK0.48575086
82BMPR20.46868215
83MAP3K110.44088212
84MAP3K70.43869334
85SGK10.43685286
86TAOK30.43186418
87MAPKAPK20.42878693
88MAP3K130.42224026
89PKN10.39209022
90PIK3CG0.38163158
91STK100.37842670
92NME20.37438646
93KSR20.37193115
94EPHB20.36883689
95MAPK120.36109972
96ICK0.35432651
97RPS6KA20.34604295
98HCK0.32901737
99HIPK20.32522952
100ABL10.32345094

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.20067128
2Linoleic acid metabolism_Homo sapiens_hsa005914.85114094
3Ether lipid metabolism_Homo sapiens_hsa005653.53088555
4Arachidonic acid metabolism_Homo sapiens_hsa005903.48255974
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.85010288
6Sphingolipid metabolism_Homo sapiens_hsa006002.19065090
7GnRH signaling pathway_Homo sapiens_hsa049122.05026371
8VEGF signaling pathway_Homo sapiens_hsa043702.02990490
9Ovarian steroidogenesis_Homo sapiens_hsa049131.96488105
10Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.95695254
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76946722
12Staphylococcus aureus infection_Homo sapiens_hsa051501.71470615
13Amoebiasis_Homo sapiens_hsa051461.61821846
14Circadian rhythm_Homo sapiens_hsa047101.55277888
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54476255
16Long-term depression_Homo sapiens_hsa047301.49655220
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43964991
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.41484197
19Pertussis_Homo sapiens_hsa051331.31457822
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.29329597
21Serotonergic synapse_Homo sapiens_hsa047261.15524945
22Choline metabolism in cancer_Homo sapiens_hsa052311.15329536
23Histidine metabolism_Homo sapiens_hsa003401.14710887
24Tuberculosis_Homo sapiens_hsa051521.04218484
25Ras signaling pathway_Homo sapiens_hsa040141.04104665
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03378139
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00227411
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00141512
29Acute myeloid leukemia_Homo sapiens_hsa052211.00031250
30Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99134512
31NF-kappa B signaling pathway_Homo sapiens_hsa040640.96468027
32Malaria_Homo sapiens_hsa051440.94283334
33Rheumatoid arthritis_Homo sapiens_hsa053230.94055731
34Dorso-ventral axis formation_Homo sapiens_hsa043200.93433570
35Phototransduction_Homo sapiens_hsa047440.91953111
36TNF signaling pathway_Homo sapiens_hsa046680.91405831
37Platelet activation_Homo sapiens_hsa046110.90757998
38Salmonella infection_Homo sapiens_hsa051320.89537431
39Sphingolipid signaling pathway_Homo sapiens_hsa040710.86496523
40Influenza A_Homo sapiens_hsa051640.84921079
41Salivary secretion_Homo sapiens_hsa049700.83046633
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81710840
43Bladder cancer_Homo sapiens_hsa052190.79306045
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.78897535
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75082343
46Hepatitis C_Homo sapiens_hsa051600.74648287
47Renin secretion_Homo sapiens_hsa049240.74252224
48Osteoclast differentiation_Homo sapiens_hsa043800.72791917
49Adherens junction_Homo sapiens_hsa045200.72210822
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70253168
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67369087
52Toxoplasmosis_Homo sapiens_hsa051450.66278027
53Leishmaniasis_Homo sapiens_hsa051400.65610173
54Collecting duct acid secretion_Homo sapiens_hsa049660.64963079
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63020534
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.62818260
57Oxytocin signaling pathway_Homo sapiens_hsa049210.62241194
58Lysosome_Homo sapiens_hsa041420.62029215
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.60369234
60Renal cell carcinoma_Homo sapiens_hsa052110.59904933
61Endocytosis_Homo sapiens_hsa041440.58921474
62MAPK signaling pathway_Homo sapiens_hsa040100.57067245
63Mineral absorption_Homo sapiens_hsa049780.55929179
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55557854
65Shigellosis_Homo sapiens_hsa051310.55091687
66Glioma_Homo sapiens_hsa052140.54758276
67MicroRNAs in cancer_Homo sapiens_hsa052060.54349512
68Notch signaling pathway_Homo sapiens_hsa043300.51316225
69Fat digestion and absorption_Homo sapiens_hsa049750.50205554
70PPAR signaling pathway_Homo sapiens_hsa033200.48405993
71ABC transporters_Homo sapiens_hsa020100.48075178
72Tight junction_Homo sapiens_hsa045300.46894102
73Pancreatic secretion_Homo sapiens_hsa049720.46646513
74p53 signaling pathway_Homo sapiens_hsa041150.45804718
75Glutamatergic synapse_Homo sapiens_hsa047240.44095104
76Legionellosis_Homo sapiens_hsa051340.43880148
77Phagosome_Homo sapiens_hsa041450.43800566
78HIF-1 signaling pathway_Homo sapiens_hsa040660.41974800
79Vibrio cholerae infection_Homo sapiens_hsa051100.41840736
80Proteoglycans in cancer_Homo sapiens_hsa052050.41778187
81Insulin signaling pathway_Homo sapiens_hsa049100.39489568
82Fatty acid elongation_Homo sapiens_hsa000620.39210297
83Chemokine signaling pathway_Homo sapiens_hsa040620.38377807
84ECM-receptor interaction_Homo sapiens_hsa045120.36849557
85Rap1 signaling pathway_Homo sapiens_hsa040150.36364610
86ErbB signaling pathway_Homo sapiens_hsa040120.35887186
87Estrogen signaling pathway_Homo sapiens_hsa049150.35877127
88Graft-versus-host disease_Homo sapiens_hsa053320.35862217
89Asthma_Homo sapiens_hsa053100.35603272
90Melanogenesis_Homo sapiens_hsa049160.35026694
91Inositol phosphate metabolism_Homo sapiens_hsa005620.34045272
92Pancreatic cancer_Homo sapiens_hsa052120.33810159
93Gastric acid secretion_Homo sapiens_hsa049710.33710483
94Long-term potentiation_Homo sapiens_hsa047200.33684496
95African trypanosomiasis_Homo sapiens_hsa051430.33476539
96Allograft rejection_Homo sapiens_hsa053300.33176667
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.32778739
98Phenylalanine metabolism_Homo sapiens_hsa003600.31730545
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31411246
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28479863

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