IL37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)9.32914557
2epidermal cell differentiation (GO:0009913)7.94267611
3peptide cross-linking (GO:0018149)7.91526894
4molting cycle (GO:0042303)7.42339092
5hair cycle (GO:0042633)7.42339092
6long-chain fatty acid biosynthetic process (GO:0042759)6.93651997
7epidermis development (GO:0008544)6.86924066
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.83827134
9keratinocyte development (GO:0003334)5.99623073
10intermediate filament organization (GO:0045109)5.99427944
11linoleic acid metabolic process (GO:0043651)5.90301245
12lipoxygenase pathway (GO:0019372)5.76110226
13skin morphogenesis (GO:0043589)5.72315663
14phosphatidylserine acyl-chain remodeling (GO:0036150)5.52096065
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.49693372
16hemidesmosome assembly (GO:0031581)5.37934407
17surfactant homeostasis (GO:0043129)4.60425674
18establishment of tissue polarity (GO:0007164)4.57426121
19establishment of planar polarity (GO:0001736)4.57426121
20lateral sprouting from an epithelium (GO:0060601)4.56537730
21epithelial cell differentiation involved in prostate gland development (GO:0060742)4.47945111
22polarized epithelial cell differentiation (GO:0030859)4.39197504
23phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.37568090
24phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.36571741
25regulation of keratinocyte differentiation (GO:0045616)4.16070598
26detection of bacterium (GO:0016045)4.05527067
27intermediate filament cytoskeleton organization (GO:0045104)4.02860038
28phosphatidylcholine acyl-chain remodeling (GO:0036151)3.94667769
29gap junction assembly (GO:0016264)3.93909205
30chemical homeostasis within a tissue (GO:0048875)3.91886928
31intermediate filament-based process (GO:0045103)3.88537906
32fatty acid elongation (GO:0030497)3.79854902
33detection of other organism (GO:0098543)3.66310018
34negative regulation of keratinocyte proliferation (GO:0010839)3.56484269
35epithelium development (GO:0060429)3.46830496
36polyol transport (GO:0015791)3.42966062
37phosphatidylserine metabolic process (GO:0006658)3.36654810
38intestinal epithelial cell development (GO:0060576)3.32108664
39regulation of keratinocyte proliferation (GO:0010837)3.23804599
40positive regulation of epidermal cell differentiation (GO:0045606)3.22044834
41one-carbon compound transport (GO:0019755)3.21177185
42negative regulation of interferon-gamma production (GO:0032689)3.18410637
43regulation of transforming growth factor beta1 production (GO:0032908)3.07330609
44ceramide biosynthetic process (GO:0046513)3.06476396
45hair follicle morphogenesis (GO:0031069)3.00193067
46keratinization (GO:0031424)21.2586019
47establishment of skin barrier (GO:0061436)20.1767621
48ectoderm development (GO:0007398)2.99210111
49fibrinolysis (GO:0042730)2.98440551
50regulation of epidermal cell differentiation (GO:0045604)2.97980800
51regulation of natural killer cell differentiation (GO:0032823)2.95838479
52phospholipid catabolic process (GO:0009395)2.89387902
53regulation of glomerular filtration (GO:0003093)2.86938925
54regulation of epidermis development (GO:0045682)2.86835494
55hair cycle process (GO:0022405)2.84645875
56molting cycle process (GO:0022404)2.84645875
57positive regulation of keratinocyte differentiation (GO:0045618)2.84588315
58hair cell differentiation (GO:0035315)2.80142277
59regulation of cholesterol homeostasis (GO:2000188)2.77866454
60retinol metabolic process (GO:0042572)2.76193401
61alditol phosphate metabolic process (GO:0052646)2.75765593
62skin development (GO:0043588)2.74785867
63hair follicle development (GO:0001942)2.73420299
64epithelial cell proliferation (GO:0050673)2.65476117
65eyelid development in camera-type eye (GO:0061029)2.60442836
66cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.60036906
67negative regulation of epidermal cell differentiation (GO:0045605)2.54397050
68positive regulation of epidermis development (GO:0045684)2.52931313
69cellular response to antibiotic (GO:0071236)2.51500869
70auditory receptor cell differentiation (GO:0042491)2.51067964
71epithelial cell-cell adhesion (GO:0090136)2.47161907
72prostanoid biosynthetic process (GO:0046457)2.44629826
73prostaglandin biosynthetic process (GO:0001516)2.44629826
74sphingolipid biosynthetic process (GO:0030148)2.44356386
75inner ear receptor cell differentiation (GO:0060113)2.41858531
76lens fiber cell development (GO:0070307)2.40949233
77ventricular cardiac muscle cell action potential (GO:0086005)2.40647693
78magnesium ion transport (GO:0015693)2.39950670
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39488683
80protein K11-linked deubiquitination (GO:0035871)2.38882394
81negative regulation of epidermis development (GO:0045683)2.36814499
82genitalia morphogenesis (GO:0035112)2.36146966
83positive regulation of interleukin-8 secretion (GO:2000484)2.35674953
84phosphatidylglycerol metabolic process (GO:0046471)2.34880845
85plasma membrane repair (GO:0001778)2.33161647
86phospholipid efflux (GO:0033700)2.31414325
87positive regulation of Notch signaling pathway (GO:0045747)2.31369369
88hypotonic response (GO:0006971)2.29094776
89regulation of chemokine secretion (GO:0090196)2.28666458
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.28501095
91cell-cell junction assembly (GO:0007043)2.27339790
92unsaturated fatty acid biosynthetic process (GO:0006636)2.27068933
93arachidonic acid secretion (GO:0050482)2.26866914
94icosanoid secretion (GO:0032309)2.26866914
95renal system process involved in regulation of blood volume (GO:0001977)2.24533772
96regulation of water loss via skin (GO:0033561)17.2586914
97desmosome organization (GO:0002934)14.9625907
98multicellular organismal water homeostasis (GO:0050891)11.2022417
99keratinocyte proliferation (GO:0043616)10.6963743
100keratinocyte differentiation (GO:0030216)10.0705622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.35693456
2P63_26484246_Chip-Seq_KERATINOCYTES_Human4.09749782
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.88108851
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.77456033
5TP63_23658742_ChIP-Seq_EP156T_Human2.25629627
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.20098025
7SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.20098025
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14495392
9RXR_22108803_ChIP-Seq_LS180_Human2.11755267
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.04455921
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02753015
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.02510215
13TP63_17297297_ChIP-ChIP_HaCaT_Human14.5763688
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.91135048
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82858474
16TP63_22573176_ChIP-Seq_HFKS_Human1.64102946
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.51469648
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42650976
19ZNF263_19887448_ChIP-Seq_K562_Human1.41732379
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40149331
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38704942
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.32324293
23FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29838003
24CJUN_26792858_Chip-Seq_BT549_Human1.29190513
25KLF5_25053715_ChIP-Seq_YYC3_Human1.28033573
26EGR1_19032775_ChIP-ChIP_M12_Human1.27139023
27GATA3_24758297_ChIP-Seq_MCF-7_Human1.26595533
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24775473
29UBF1/2_26484160_Chip-Seq_HMECs_Human1.24064652
30SOX2_20726797_ChIP-Seq_SW620_Human1.23714022
31GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23519474
32AHR_22903824_ChIP-Seq_MCF-7_Human1.22916824
33TP53_18474530_ChIP-ChIP_U2OS_Human1.18281970
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17756767
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15476594
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15476594
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14669982
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12968040
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12430855
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11503567
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.10199728
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09052339
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06966487
44GATA4_25053715_ChIP-Seq_YYC3_Human1.05621301
45AR_21572438_ChIP-Seq_LNCaP_Human1.05387772
46GATA6_21074721_ChIP-Seq_CACO-2_Human1.02901961
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00611108
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.00330557
49CDX2_20551321_ChIP-Seq_CACO-2_Human0.99734662
50FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98739181
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97035333
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97031733
53GATA6_25053715_ChIP-Seq_YYC3_Human0.96680184
54RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96251119
55ATF3_27146783_Chip-Seq_COLON_Human0.94530115
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92222969
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92105180
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90640364
59CLOCK_20551151_ChIP-Seq_293T_Human0.85263642
60RACK7_27058665_Chip-Seq_MCF-7_Human0.84934718
61TP53_16413492_ChIP-PET_HCT116_Human0.83299777
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81863210
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81398049
64P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78513894
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77741870
66CTCF_27219007_Chip-Seq_Bcells_Human0.77646181
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77552726
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77350500
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77072610
70CDX2_22108803_ChIP-Seq_LS180_Human0.75097338
71ERG_20517297_ChIP-Seq_VCAP_Human0.74938025
72PIAS1_25552417_ChIP-Seq_VCAP_Human0.74488511
73TCF4_22108803_ChIP-Seq_LS180_Human0.74361960
74FOXA1_25552417_ChIP-Seq_VCAP_Human0.73533971
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.70180781
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69659450
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69414510
78P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.69213808
79TAF2_19829295_ChIP-Seq_ESCs_Human0.68983041
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67433308
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67034458
82P53_21459846_ChIP-Seq_SAOS-2_Human0.63877230
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.63874100
84HNFA_21074721_ChIP-Seq_CACO-2_Human0.63424536
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62438846
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61741527
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61062484
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.59932731
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.59383416
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.59083963
91RBPJ_21746931_ChIP-Seq_IB4_Human0.58830135
92TBX20_22328084_ChIP-Seq_HEART_Mouse0.58603566
93TBX20_22080862_ChIP-Seq_HEART_Mouse0.58603566
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57632868
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.57259372
96MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.56802395
97CEBPB_22108803_ChIP-Seq_LS180_Human0.56766434
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.56333796
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.55917968
100SMAD4_21741376_ChIP-Seq_ESCs_Human0.55817100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.75094437
2MP0005275_abnormal_skin_tensile7.23762545
3MP0009379_abnormal_foot_pigmentation6.52954856
4MP0010234_abnormal_vibrissa_follicle5.09735803
5MP0005501_abnormal_skin_physiology4.83564104
6MP0000579_abnormal_nail_morphology3.42931576
7MP0001216_abnormal_epidermal_layer3.21012785
8MP0003453_abnormal_keratinocyte_physiol3.12597974
9MP0010678_abnormal_skin_adnexa2.90776695
10MP0004947_skin_inflammation2.87174017
11MP0000566_synostosis2.84510738
12MP0003941_abnormal_skin_development2.78474842
13MP0000383_abnormal_hair_follicle2.74975010
14MP0010771_integument_phenotype2.67169064
15MP0004381_abnormal_hair_follicle2.64173944
16MP0002060_abnormal_skin_morphology2.56305695
17MP0001188_hyperpigmentation2.50482296
18MP0000015_abnormal_ear_pigmentation2.35008961
19MP0005174_abnormal_tail_pigmentation2.30860935
20MP0002095_abnormal_skin_pigmentation2.23039587
21MP0000377_abnormal_hair_follicle2.14074000
22MP0002098_abnormal_vibrissa_morphology2.12197246
23MP0000647_abnormal_sebaceous_gland1.95136591
24MP0004782_abnormal_surfactant_physiolog1.93456818
25MP0003705_abnormal_hypodermis_morpholog1.80117957
26MP0009931_abnormal_skin_appearance1.68331316
27MP0005409_darkened_coat_color1.66340634
28MP0003191_abnormal_cellular_cholesterol1.56202996
29MP0000427_abnormal_hair_cycle1.52921655
30MP0003011_delayed_dark_adaptation1.52666383
31MP0000467_abnormal_esophagus_morphology1.48769548
32MP0000465_gastrointestinal_hemorrhage1.44255210
33MP0003566_abnormal_cell_adhesion1.37893709
34MP0000367_abnormal_coat/_hair1.34662654
35MP0001191_abnormal_skin_condition1.32230512
36MP0002177_abnormal_outer_ear1.14357232
37MP0001243_abnormal_dermal_layer1.03180261
38MP0001984_abnormal_olfaction0.99677549
39MP0000762_abnormal_tongue_morphology0.97612758
40MP0005023_abnormal_wound_healing0.97281483
41MP0005075_abnormal_melanosome_morpholog0.92797969
42MP0009780_abnormal_chondrocyte_physiolo0.92431446
43MP0009053_abnormal_anal_canal0.87447416
44MP0001851_eye_inflammation0.84714139
45MP0001784_abnormal_fluid_regulation0.75825576
46MP0002009_preneoplasia0.74580884
47MP0010352_gastrointestinal_tract_polyps0.72515540
48MP0000569_abnormal_digit_pigmentation0.71456459
49MP0005171_absent_coat_pigmentation0.70682425
50MP0008438_abnormal_cutaneous_collagen0.67179741
51MP0002877_abnormal_melanocyte_morpholog0.66684565
52MP0010030_abnormal_orbit_morphology0.64351658
53MP0000372_irregular_coat_pigmentation0.61026753
54MP0008789_abnormal_olfactory_epithelium0.58080572
55MP0001340_abnormal_eyelid_morphology0.56649191
56MP0005503_abnormal_tendon_morphology0.55924893
57MP0005257_abnormal_intraocular_pressure0.54172147
58MP0000627_abnormal_mammary_gland0.52093997
59MP0004885_abnormal_endolymph0.51169965
60MP0005377_hearing/vestibular/ear_phenot0.51045384
61MP0003878_abnormal_ear_physiology0.51045384
62MP0003638_abnormal_response/metabolism_0.47728806
63MP0002282_abnormal_trachea_morphology0.47526361
64MP0005394_taste/olfaction_phenotype0.46749834
65MP0005499_abnormal_olfactory_system0.46749834
66MP0002233_abnormal_nose_morphology0.46391367
67MP0002234_abnormal_pharynx_morphology0.44277963
68MP0004264_abnormal_extraembryonic_tissu0.44054300
69MP0005197_abnormal_uvea_morphology0.42193361
70MP0009384_cardiac_valve_regurgitation0.41859719
71MP0003763_abnormal_thymus_physiology0.41140658
72MP0009333_abnormal_splenocyte_physiolog0.40789208
73MP0002133_abnormal_respiratory_system0.39668571
74MP0005388_respiratory_system_phenotype0.39668571
75MP0005076_abnormal_cell_differentiation0.39195903
76MP0002111_abnormal_tail_morphology0.38682846
77MP0003828_pulmonary_edema0.36977146
78MP0000428_abnormal_craniofacial_morphol0.36058724
79MP0000462_abnormal_digestive_system0.35541393
80MP0001958_emphysema0.35355606
81MP0002006_tumorigenesis0.33153900
82MP0001186_pigmentation_phenotype0.32723452
83MP0005508_abnormal_skeleton_morphology0.27879986
84MP0003315_abnormal_perineum_morphology0.27191117
85MP0002166_altered_tumor_susceptibility0.26787989
86MP0008004_abnormal_stomach_pH0.25283651
87MP0003950_abnormal_plasma_membrane0.25046471
88MP0002697_abnormal_eye_size0.24576482
89MP0005408_hypopigmentation0.23770454
90MP0001853_heart_inflammation0.23244131
91MP0000432_abnormal_head_morphology0.22941273
92MP0003755_abnormal_palate_morphology0.22622206
93MP0005193_abnormal_anterior_eye0.22559029
94MP0004185_abnormal_adipocyte_glucose0.21739221
95MP0003300_gastrointestinal_ulcer0.20753570
96MP0005248_abnormal_Harderian_gland0.20211649
97MP0003279_aneurysm0.19108453
98MP0002109_abnormal_limb_morphology0.18468124
99MP0002092_abnormal_eye_morphology0.18352397
100MP0000685_abnormal_immune_system0.17985826

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.41904480
2Erythroderma (HP:0001019)8.06802664
3Palmoplantar hyperkeratosis (HP:0000972)7.90059910
4Congenital ichthyosiform erythroderma (HP:0007431)7.58669688
5Hypotrichosis (HP:0001006)7.56781054
6Palmar hyperkeratosis (HP:0010765)7.53949656
7Abnormality of nail color (HP:0100643)6.93764558
8Erythema (HP:0010783)6.79150671
9Plantar hyperkeratosis (HP:0007556)6.67034970
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.52621622
11Thick nail (HP:0001805)5.86670114
12Alopecia of scalp (HP:0002293)5.86242963
13Abnormality of the axillary hair (HP:0100134)5.77472472
14Abnormality of secondary sexual hair (HP:0009888)5.77472472
15Conjunctival hamartoma (HP:0100780)5.64422976
16Fragile nails (HP:0001808)4.87572861
17Woolly hair (HP:0002224)4.87252123
18Parakeratosis (HP:0001036)4.73952021
19Onycholysis (HP:0001806)4.73604283
20Corneal erosion (HP:0200020)4.71820579
21Right ventricular cardiomyopathy (HP:0011663)4.62110334
22Eczematoid dermatitis (HP:0000976)4.46829782
23Palmoplantar keratoderma (HP:0000982)4.35205618
24Abnormal blistering of the skin (HP:0008066)3.89805248
25Gangrene (HP:0100758)3.79157920
26Hamartoma of the eye (HP:0010568)3.64839459
27Abnormality of the salivary glands (HP:0010286)3.64536362
28Hypohidrosis (HP:0000966)3.54769087
29Sparse eyelashes (HP:0000653)3.43401433
30Lip pit (HP:0100267)3.38558252
31Sparse scalp hair (HP:0002209)3.20849628
32Aplasia involving bones of the upper limbs (HP:0009823)3.18823476
33Aplasia of the phalanges of the hand (HP:0009802)3.18823476
34Aplasia involving bones of the extremities (HP:0009825)3.18823476
35Ectropion (HP:0000656)3.11764686
36Oral leukoplakia (HP:0002745)2.90536215
37Nail dystrophy (HP:0008404)2.86302248
38Selective tooth agenesis (HP:0001592)2.82797173
39Abnormal hair laboratory examination (HP:0003328)2.80298107
40Absent eyelashes (HP:0000561)2.79037126
41Split foot (HP:0001839)2.75791192
42Pruritus (HP:0000989)2.72296122
43Abnormality of permanent molar morphology (HP:0011071)2.68819166
44Abnormality of the dental root (HP:0006486)2.68819166
45Taurodontia (HP:0000679)2.68819166
46Hypoplastic labia majora (HP:0000059)2.68464996
47Pili torti (HP:0003777)2.63789181
48Nasolacrimal duct obstruction (HP:0000579)2.55394415
49Abnormality of molar (HP:0011077)2.53375199
50Abnormality of molar morphology (HP:0011070)2.53375199
51Abnormality of the labia majora (HP:0012881)2.43231358
52Abnormality of the dental pulp (HP:0006479)2.41840739
53Natal tooth (HP:0000695)2.41768855
54Milia (HP:0001056)2.41321374
55Xerostomia (HP:0000217)2.40391230
56Conical tooth (HP:0000698)2.35213922
57Melanocytic nevus (HP:0000995)2.34671090
58Abnormality of hair growth rate (HP:0011363)2.22548916
59Slow-growing hair (HP:0002217)2.22548916
60Ridged nail (HP:0001807)2.20406962
61Hamartoma (HP:0010566)2.14120493
62Lack of skin elasticity (HP:0100679)2.13618145
63Blepharitis (HP:0000498)2.13188171
64Curly hair (HP:0002212)2.10027330
65Neonatal death (HP:0003811)2.09743494
66Hypergammaglobulinemia (HP:0010702)2.08361041
67Hyperhidrosis (HP:0000975)2.07054150
68Septate vagina (HP:0001153)2.06070440
69Duplicated collecting system (HP:0000081)2.04231662
70Advanced eruption of teeth (HP:0006288)2.04135646
71Follicular hyperkeratosis (HP:0007502)2.02184354
72Acanthosis nigricans (HP:0000956)2.01941073
73Anhidrosis (HP:0000970)2.01289161
74Absent hair (HP:0002298)2.01285267
75Oligodontia (HP:0000677)1.99717715
76Abnormality of the lacrimal duct (HP:0011481)1.98674675
77Dry hair (HP:0011359)1.90416081
78Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.83473947
79Dry skin (HP:0000958)1.82477928
80Ventricular tachycardia (HP:0004756)1.79364372
81Abnormality of the nasolacrimal system (HP:0000614)1.76619140
82Depressed nasal tip (HP:0000437)1.74247650
83Abnormality of the renal collecting system (HP:0004742)1.73935785
84Axonal loss (HP:0003447)1.71222542
85Osteolytic defects of the hand bones (HP:0009699)1.69631238
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.69631238
87Dehydration (HP:0001944)1.65763710
88Furrowed tongue (HP:0000221)1.65652601
89Skin ulcer (HP:0200042)1.65622241
90Hypoplasia of dental enamel (HP:0006297)1.64447082
91Anonychia (HP:0001798)1.59201634
92Segmental peripheral demyelination/remyelination (HP:0003481)1.55451323
93Coronal craniosynostosis (HP:0004440)1.53855206
94Breast hypoplasia (HP:0003187)1.51697664
95Laryngomalacia (HP:0001601)1.50024865
96Premature loss of primary teeth (HP:0006323)1.48613074
97Labial hypoplasia (HP:0000066)1.48131882
98Abnormality of sodium homeostasis (HP:0010931)1.46651940
99Abnormality of incisor morphology (HP:0011063)1.45754100
100Long nose (HP:0003189)1.45638012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.53939623
2TGFBR14.94180039
3EEF2K4.55484086
4MST1R3.95529495
5FGFR13.84069929
6MAP3K63.78264722
7MAPKAPK33.75558129
8EPHA22.75222235
9FER2.52928234
10FGFR32.27790063
11TRPM72.09496335
12MET1.91026422
13MAPK71.85844661
14SGK2231.73141428
15SGK4941.73141428
16LATS11.71336673
17MAPKAPK51.70934604
18MAP3K21.60332879
19MAPK121.58137406
20RPS6KB21.51565602
21PRKD21.48804586
22STK31.47710887
23WNK11.44607681
24FGFR21.42934301
25PIK3CG1.40031313
26MAP3K31.35206414
27TGFBR21.18686338
28RIPK11.15872444
29MAP3K71.13297893
30EPHB11.12926933
31MAP2K61.08948386
32PTK21.00356729
33MAPK150.96741534
34MAP3K10.96403789
35GSK3A0.94221659
36ERN10.93960538
37RPS6KB10.92337071
38MARK20.91365467
39ICK0.87634912
40KIT0.87081923
41LATS20.86799516
42BRSK20.83637220
43STK38L0.83207849
44SIK10.83066707
45EPHB20.81073286
46PRKCE0.80610708
47EPHA30.78956292
48PRKAA20.78172482
49LRRK20.77366164
50NLK0.74346630
51MOS0.74252296
52DMPK0.73117806
53NEK90.71941154
54MINK10.67630867
55IRAK10.67104998
56MAPKAPK20.66278233
57STK390.65303439
58STK100.61933236
59IKBKB0.58678103
60BMX0.58398846
61LMTK20.58173568
62GRK70.57520077
63MTOR0.57283726
64BRD40.57232121
65ADRBK10.56170729
66PRPF4B0.53615169
67PBK0.50884426
68MAP2K40.49389431
69MAP3K90.47437588
70MKNK10.46066697
71SGK20.45970952
72SGK10.44141302
73MKNK20.41695416
74CDK60.39334462
75YES10.39099457
76BCR0.39051797
77SIK30.38690161
78SGK30.36616068
79IGF1R0.35210136
80ILK0.33232668
81TAF10.32964239
82PKN10.31406630
83PDGFRB0.30894050
84EIF2AK30.30279635
85ERBB30.29080545
86CDK120.29014765
87PDGFRA0.28119958
88ABL10.26880689
89STK380.25985955
90ABL20.22578797
91PAK40.22340686
92EIF2AK20.21917659
93CDK30.21779122
94IRAK30.21741973
95MAP3K120.20820778
96PTK60.20713814
97PRKCH0.20626569
98MAPK90.20401072
99AKT30.20388496
100CHUK0.20239319

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.07825961
2Linoleic acid metabolism_Homo sapiens_hsa005914.69590815
3Ether lipid metabolism_Homo sapiens_hsa005653.64552572
4Arachidonic acid metabolism_Homo sapiens_hsa005903.08773934
5Sphingolipid metabolism_Homo sapiens_hsa006002.90860317
6Histidine metabolism_Homo sapiens_hsa003402.81985341
7Staphylococcus aureus infection_Homo sapiens_hsa051502.80148585
8Circadian rhythm_Homo sapiens_hsa047102.43844182
9GnRH signaling pathway_Homo sapiens_hsa049121.92846471
10Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.67878320
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64812455
12VEGF signaling pathway_Homo sapiens_hsa043701.64277708
13Dorso-ventral axis formation_Homo sapiens_hsa043201.63836675
14ECM-receptor interaction_Homo sapiens_hsa045121.63162211
15Fatty acid elongation_Homo sapiens_hsa000621.54736911
16Ovarian steroidogenesis_Homo sapiens_hsa049131.52534229
17Notch signaling pathway_Homo sapiens_hsa043301.38987329
18Phototransduction_Homo sapiens_hsa047441.36861554
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32753330
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.27480598
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.20033753
22Ras signaling pathway_Homo sapiens_hsa040141.18642272
23Long-term depression_Homo sapiens_hsa047301.18570123
24Adherens junction_Homo sapiens_hsa045201.14093971
25Amoebiasis_Homo sapiens_hsa051461.13560851
26Choline metabolism in cancer_Homo sapiens_hsa052311.12421879
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08632763
28Phenylalanine metabolism_Homo sapiens_hsa003601.04805438
29Renin secretion_Homo sapiens_hsa049241.03874028
30Retinol metabolism_Homo sapiens_hsa008301.03176969
31Sphingolipid signaling pathway_Homo sapiens_hsa040710.96924542
32MicroRNAs in cancer_Homo sapiens_hsa052060.95656732
33Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95507130
34Serotonergic synapse_Homo sapiens_hsa047260.92767574
35Pertussis_Homo sapiens_hsa051330.92414083
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91778467
37p53 signaling pathway_Homo sapiens_hsa041150.89364259
38Vitamin digestion and absorption_Homo sapiens_hsa049770.88034909
39Melanogenesis_Homo sapiens_hsa049160.87362937
40Proteoglycans in cancer_Homo sapiens_hsa052050.84275910
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80491991
42Basal cell carcinoma_Homo sapiens_hsa052170.80406281
43Fatty acid biosynthesis_Homo sapiens_hsa000610.78682049
44Platelet activation_Homo sapiens_hsa046110.77355466
45Tight junction_Homo sapiens_hsa045300.73369261
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69838041
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66470341
48Thyroid cancer_Homo sapiens_hsa052160.63031399
49Inositol phosphate metabolism_Homo sapiens_hsa005620.63024282
50Complement and coagulation cascades_Homo sapiens_hsa046100.62044439
51Lysosome_Homo sapiens_hsa041420.61473438
52Toxoplasmosis_Homo sapiens_hsa051450.60198331
53Oxytocin signaling pathway_Homo sapiens_hsa049210.60166628
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60103260
55Endocytosis_Homo sapiens_hsa041440.59225290
56Hedgehog signaling pathway_Homo sapiens_hsa043400.58383839
57Rap1 signaling pathway_Homo sapiens_hsa040150.58147125
58Glioma_Homo sapiens_hsa052140.55674153
59Bladder cancer_Homo sapiens_hsa052190.55286123
60Tuberculosis_Homo sapiens_hsa051520.55041406
61Hippo signaling pathway_Homo sapiens_hsa043900.54330713
62Fat digestion and absorption_Homo sapiens_hsa049750.53489572
63Small cell lung cancer_Homo sapiens_hsa052220.52950411
64Nitrogen metabolism_Homo sapiens_hsa009100.52024305
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.51956495
66Mineral absorption_Homo sapiens_hsa049780.51710519
67Renal cell carcinoma_Homo sapiens_hsa052110.51250096
68Asthma_Homo sapiens_hsa053100.51036426
69Pathways in cancer_Homo sapiens_hsa052000.50579145
70Axon guidance_Homo sapiens_hsa043600.50187255
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49502365
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49400655
73Focal adhesion_Homo sapiens_hsa045100.46905304
74beta-Alanine metabolism_Homo sapiens_hsa004100.45491078
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44072650
76Wnt signaling pathway_Homo sapiens_hsa043100.43698479
77ABC transporters_Homo sapiens_hsa020100.42568048
78Phagosome_Homo sapiens_hsa041450.42361079
79Tyrosine metabolism_Homo sapiens_hsa003500.41105468
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40965987
81Salivary secretion_Homo sapiens_hsa049700.40930320
82Pancreatic cancer_Homo sapiens_hsa052120.40073706
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.40022586
84Hepatitis C_Homo sapiens_hsa051600.39915731
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.39650500
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.39291084
87MAPK signaling pathway_Homo sapiens_hsa040100.37819163
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.36655727
89Glutamatergic synapse_Homo sapiens_hsa047240.36608275
90Influenza A_Homo sapiens_hsa051640.35582378
91Protein digestion and absorption_Homo sapiens_hsa049740.34653131
92Acute myeloid leukemia_Homo sapiens_hsa052210.34049363
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32645584
94Pancreatic secretion_Homo sapiens_hsa049720.32290578
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30201987
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29976422
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.29755377
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29096443
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28119600
100PPAR signaling pathway_Homo sapiens_hsa033200.28109190

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