IL3RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.17679139
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.17679139
3antigen processing and presentation of endogenous antigen (GO:0019883)5.44110338
4antigen processing and presentation via MHC class Ib (GO:0002475)4.29876239
5immunoglobulin mediated immune response (GO:0016064)4.07314698
6positive regulation by symbiont of host defense response (GO:0052509)4.03739650
7modulation by symbiont of host defense response (GO:0052031)4.03739650
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.03739650
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.03739650
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.03739650
11modulation by symbiont of host immune response (GO:0052553)4.03739650
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83271696
13T-helper 1 type immune response (GO:0042088)3.81158225
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.79692040
15neutrophil activation involved in immune response (GO:0002283)3.71478205
16regulation of vitamin D biosynthetic process (GO:0060556)3.70554513
17detection of other organism (GO:0098543)3.57189263
18positive regulation of gamma-delta T cell activation (GO:0046645)3.56774812
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54353729
20response to peptidoglycan (GO:0032494)3.50879099
21positive regulation of B cell differentiation (GO:0045579)3.48133282
22germinal center formation (GO:0002467)3.47327202
23detection of bacterium (GO:0016045)3.43719158
24NIK/NF-kappaB signaling (GO:0038061)3.40812789
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34614080
26positive regulation of heat generation (GO:0031652)3.28647731
27respiratory burst (GO:0045730)3.28053050
28negative regulation of phagocytosis (GO:0050765)3.27012705
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26294903
30positive regulation of type 2 immune response (GO:0002830)3.22644630
31ribosomal small subunit assembly (GO:0000028)3.21675020
32response to muramyl dipeptide (GO:0032495)3.21321183
33regulation of interferon-beta biosynthetic process (GO:0045357)3.16973428
34negative regulation of interleukin-12 production (GO:0032695)3.14336708
35positive regulation of interferon-alpha production (GO:0032727)3.14278835
36response to type I interferon (GO:0034340)3.13735742
37cellular response to type I interferon (GO:0071357)3.13092141
38type I interferon signaling pathway (GO:0060337)3.13092141
39positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.12502273
40positive regulation of antigen processing and presentation (GO:0002579)3.12367507
41B cell mediated immunity (GO:0019724)3.12301535
42positive regulation of cellular amide metabolic process (GO:0034250)3.09011447
43cellular response to interferon-gamma (GO:0071346)3.06863271
44detection of external biotic stimulus (GO:0098581)3.05449532
45regulation of mast cell activation (GO:0033003)3.04489730
46regulation of type I interferon-mediated signaling pathway (GO:0060338)3.04251643
47regulation of interleukin-12 production (GO:0032655)3.01487930
48regulation of interferon-alpha production (GO:0032647)2.99740099
49response to interferon-beta (GO:0035456)2.96759722
50detection of molecule of bacterial origin (GO:0032490)2.96550124
51macrophage activation (GO:0042116)2.95021353
52positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94368459
53regulation of vitamin metabolic process (GO:0030656)2.88881565
54microglial cell activation (GO:0001774)2.88295264
55response to interferon-gamma (GO:0034341)2.87713526
56macrophage activation involved in immune response (GO:0002281)2.87383316
57pentose-phosphate shunt (GO:0006098)2.86761424
58pinocytosis (GO:0006907)2.86444256
59regulation of chemokine biosynthetic process (GO:0045073)2.85377448
60regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.84854960
61regulation of T cell tolerance induction (GO:0002664)2.83404321
62actin nucleation (GO:0045010)2.82323489
63mature B cell differentiation involved in immune response (GO:0002313)2.82151632
64regulation of mast cell activation involved in immune response (GO:0033006)2.81861822
65positive regulation of NF-kappaB import into nucleus (GO:0042346)2.80692802
66response to interferon-alpha (GO:0035455)2.80561890
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80288387
68T cell apoptotic process (GO:0070231)2.79953079
69regulation of B cell differentiation (GO:0045577)2.79222511
70mannose metabolic process (GO:0006013)2.79178273
71regulation of antigen processing and presentation (GO:0002577)2.79082806
72regulation of B cell receptor signaling pathway (GO:0050855)2.78770839
73negative regulation of myeloid cell apoptotic process (GO:0033033)2.77993791
74myeloid dendritic cell differentiation (GO:0043011)2.77409542
75negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.76532657
76viral transcription (GO:0019083)2.76280658
77granulocyte activation (GO:0036230)2.75803706
78response to protozoan (GO:0001562)2.75662797
79regulation of mononuclear cell migration (GO:0071675)2.75088935
80positive regulation of T-helper cell differentiation (GO:0045624)2.74638715
81positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.73164019
82defense response to protozoan (GO:0042832)2.72212319
83detection of biotic stimulus (GO:0009595)2.72204330
84cellular response to zinc ion (GO:0071294)2.70818077
85neutrophil activation (GO:0042119)2.70532842
86regulation of T-helper cell differentiation (GO:0045622)2.69879458
87regulation of tolerance induction (GO:0002643)2.69785648
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68913097
89regulation of integrin activation (GO:0033623)2.68525673
90regulation of interleukin-2 biosynthetic process (GO:0045076)2.68511301
91myeloid dendritic cell activation (GO:0001773)2.68054419
92monocyte chemotaxis (GO:0002548)2.67766141
93negative regulation of innate immune response (GO:0045824)2.67501316
94regulation of protein heterodimerization activity (GO:0043497)2.67452757
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66057524
96negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63471131
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62830307
98regulation of interleukin-12 biosynthetic process (GO:0045075)2.62214369
99regulation of gamma-delta T cell differentiation (GO:0045586)2.61636082
100myeloid cell activation involved in immune response (GO:0002275)2.59539981
101translational termination (GO:0006415)2.58108613
102dendritic cell differentiation (GO:0097028)2.57740196
103negative regulation of granulocyte differentiation (GO:0030853)2.56449081
104T cell migration (GO:0072678)2.56255205
105regulation of gamma-delta T cell activation (GO:0046643)2.56109618
106cellular response to interferon-beta (GO:0035458)2.54970187
107interferon-gamma-mediated signaling pathway (GO:0060333)2.54961291
108positive regulation of lamellipodium assembly (GO:0010592)2.52001896
109NADPH regeneration (GO:0006740)2.51210816
110negative regulation of cytokine production involved in immune response (GO:0002719)2.50939278
111tolerance induction (GO:0002507)2.50658868
112activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.49277794
113B cell receptor signaling pathway (GO:0050853)2.49268996
114response to fungus (GO:0009620)2.47213009
115positive regulation of mast cell activation (GO:0033005)2.47130077
116response to host immune response (GO:0052572)2.46916591
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46916591
118positive regulation of histone deacetylation (GO:0031065)2.46722027
119hyaluronan catabolic process (GO:0030214)2.46289713
120regulation of mast cell degranulation (GO:0043304)2.45591250
121regulation of necroptotic process (GO:0060544)2.44934748
122leukocyte aggregation (GO:0070486)2.44800316
123low-density lipoprotein particle clearance (GO:0034383)2.43170990
124cellular extravasation (GO:0045123)2.42905413
125negative regulation of erythrocyte differentiation (GO:0045647)2.42326591
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42172114
127negative regulation of cell killing (GO:0031342)2.42114274
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.42114274
129regulation of hypersensitivity (GO:0002883)2.41070608
130positive regulation of chemokine biosynthetic process (GO:0045080)2.39563334
131regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39417611
132regulation of T-helper 1 cell differentiation (GO:0045625)2.38826359
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.38209647
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.37905125
135positive regulation of interferon-beta production (GO:0032728)2.37797304
136lymphocyte apoptotic process (GO:0070227)2.37261636
137positive regulation of mast cell degranulation (GO:0043306)2.35469964
138positive regulation of mast cell activation involved in immune response (GO:0033008)2.35469964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.54946562
2E2F7_22180533_ChIP-Seq_HELA_Human3.47497867
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.37443364
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.35289495
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.15004293
6VDR_21846776_ChIP-Seq_THP-1_Human2.88531314
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81664240
8MYC_22102868_ChIP-Seq_BL_Human2.69726863
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62216160
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55857530
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48509145
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45643148
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35776290
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.34452417
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33724563
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31944739
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30633686
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28383987
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27593061
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16287999
21SCL_19346495_ChIP-Seq_HPC-7_Human2.14958904
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10641175
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09780378
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09584357
25VDR_24763502_ChIP-Seq_THP-1_Human2.05559287
26SPI1_23547873_ChIP-Seq_NB4_Human2.02741612
27MAF_26560356_Chip-Seq_TH1_Human1.99888022
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89436891
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86983714
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.86428566
31* RUNX1_22412390_ChIP-Seq_EML_Mouse1.83868216
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83590521
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.82880435
34VDR_24787735_ChIP-Seq_THP-1_Human1.78506710
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77715006
36MYB_26560356_Chip-Seq_TH2_Human1.75128903
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74437393
38UTX_26944678_Chip-Seq_JUKART_Human1.74342197
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72609929
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71185016
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68627253
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.65466503
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61063805
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55236954
45MYB_26560356_Chip-Seq_TH1_Human1.54696462
46SPI1_23127762_ChIP-Seq_K562_Human1.51705419
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50466942
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49846237
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46571493
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.44690657
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43628167
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43289326
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43192772
54MAF_26560356_Chip-Seq_TH2_Human1.37976480
55KDM2B_26808549_Chip-Seq_DND41_Human1.37171657
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.34489129
57LXR_22292898_ChIP-Seq_THP-1_Human1.34482944
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33952175
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32993669
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.30151134
61TFEB_21752829_ChIP-Seq_HELA_Human1.29963330
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28947796
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26340882
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26270233
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24638049
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24091328
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23764524
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23552558
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23019822
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22042143
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20958877
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17235928
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16674533
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16456180
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15865006
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15424972
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15419286
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.15386987
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13073243
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10611913
81* GATA3_26560356_Chip-Seq_TH2_Human1.10261996
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10198814
83PU_27001747_Chip-Seq_BMDM_Mouse1.10014000
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09779679
85RUNX_20019798_ChIP-Seq_JUKART_Human1.09274164
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08769921
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07563699
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07554020
89P68_20966046_ChIP-Seq_HELA_Human1.07399800
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06827701
91NCOR1_26117541_ChIP-Seq_K562_Human1.06168407
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.05603678
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05365891
94XRN2_22483619_ChIP-Seq_HELA_Human1.02506810
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02282232
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02271755
97GATA1_19941826_ChIP-Seq_K562_Human1.02043650
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01840280
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98987250
100RACK7_27058665_Chip-Seq_MCF-7_Human0.97961924
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97626031
102MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97578062
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97409157
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97017233
105CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96457122
106BCL6_27268052_Chip-Seq_Bcells_Human0.96186051
107GATA1_22025678_ChIP-Seq_K562_Human0.95760790
108GATA3_27048872_Chip-Seq_THYMUS_Human0.93330161
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93247443
110CIITA_25753668_ChIP-Seq_RAJI_Human0.93155328
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92895775
112SPI1_20517297_ChIP-Seq_HL60_Human0.92675387
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92583460
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92102089
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92062613
116BCOR_27268052_Chip-Seq_Bcells_Human0.91822434
117STAT1_20625510_ChIP-Seq_HELA_Human0.91759271
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.90184574
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89766335
120* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89290035
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89131303
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88629472
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86188960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63125760
2MP0003303_peritoneal_inflammation3.19694679
3MP0003436_decreased_susceptibility_to3.14139222
4MP0000685_abnormal_immune_system2.82105444
5MP0005058_abnormal_lysosome_morphology2.62142309
6MP0009785_altered_susceptibility_to2.57477370
7MP0002138_abnormal_hepatobiliary_system2.54818086
8MP0005387_immune_system_phenotype2.42547091
9MP0001790_abnormal_immune_system2.42547091
10MP0005025_abnormal_response_to2.42525039
11MP0002419_abnormal_innate_immunity2.41891250
12MP0005000_abnormal_immune_tolerance2.39847304
13MP0002148_abnormal_hypersensitivity_rea2.26176825
14MP0009278_abnormal_bone_marrow2.25224792
15MP0002452_abnormal_antigen_presenting2.23911422
16MP0002396_abnormal_hematopoietic_system2.22052378
17MP0001800_abnormal_humoral_immune2.21274947
18MP0005464_abnormal_platelet_physiology2.14812866
19MP0005671_abnormal_response_to2.10618534
20MP0008438_abnormal_cutaneous_collagen2.07610025
21MP0002723_abnormal_immune_serum2.07418562
22MP0006082_CNS_inflammation2.07278688
23MP0001545_abnormal_hematopoietic_system2.04362037
24MP0005397_hematopoietic_system_phenotyp2.04362037
25MP0002420_abnormal_adaptive_immunity2.02865738
26MP0001819_abnormal_immune_cell2.02659484
27MP0003300_gastrointestinal_ulcer2.00776935
28MP0003724_increased_susceptibility_to1.99114691
29MP0009333_abnormal_splenocyte_physiolog1.97449439
30MP0005167_abnormal_blood-brain_barrier1.96752972
31MP0002405_respiratory_system_inflammati1.90239118
32MP0004808_abnormal_hematopoietic_stem1.87540584
33MP0004510_myositis1.84332620
34MP0003172_abnormal_lysosome_physiology1.83794664
35MP0001533_abnormal_skeleton_physiology1.81995350
36* MP0002398_abnormal_bone_marrow1.79490215
37MP0009840_abnormal_foam_cell1.73830171
38MP0003705_abnormal_hypodermis_morpholog1.73383750
39MP0002166_altered_tumor_susceptibility1.68713630
40* MP0000716_abnormal_immune_system1.66969577
41MP0000858_altered_metastatic_potential1.63912470
42MP0004947_skin_inflammation1.63616222
43MP0003566_abnormal_cell_adhesion1.63105242
44MP0003448_altered_tumor_morphology1.58028531
45MP0010352_gastrointestinal_tract_polyps1.57266332
46MP0002139_abnormal_hepatobiliary_system1.56994299
47MP0000689_abnormal_spleen_morphology1.56526219
48MP0001845_abnormal_inflammatory_respons1.54158360
49MP0010155_abnormal_intestine_physiology1.53831777
50MP0002722_abnormal_immune_system1.52129281
51* MP0002429_abnormal_blood_cell1.50757297
52MP0003806_abnormal_nucleotide_metabolis1.50603037
53MP0005451_abnormal_body_composition1.50012949
54MP0001853_heart_inflammation1.49603182
55MP0002006_tumorigenesis1.45928173
56MP0000465_gastrointestinal_hemorrhage1.44958204
57MP0000343_altered_response_to1.44747893
58MP0010307_abnormal_tumor_latency1.38461985
59MP0008469_abnormal_protein_level1.34116503
60MP0003763_abnormal_thymus_physiology1.33533877
61MP0003191_abnormal_cellular_cholesterol1.31420597
62MP0005023_abnormal_wound_healing1.28563512
63MP0005166_decreased_susceptibility_to1.27613153
64MP0000490_abnormal_crypts_of1.25918067
65MP0002877_abnormal_melanocyte_morpholog1.25306449
66MP0003279_aneurysm1.24140360
67MP0005076_abnormal_cell_differentiation1.21932235
68MP0001958_emphysema1.20740235
69MP0003656_abnormal_erythrocyte_physiolo1.18886555
70MP0002933_joint_inflammation1.18536815
71MP0005310_abnormal_salivary_gland1.16996219
72MP0001873_stomach_inflammation1.16623853
73MP0006054_spinal_hemorrhage1.15315549
74MP0001986_abnormal_taste_sensitivity1.14310060
75MP0005174_abnormal_tail_pigmentation1.12191103
76MP0003690_abnormal_glial_cell1.07828002
77MP0000703_abnormal_thymus_morphology1.06841062
78MP0002254_reproductive_system_inflammat1.05561503
79MP0001851_eye_inflammation1.04680469
80MP0002998_abnormal_bone_remodeling1.03547490
81MP0003453_abnormal_keratinocyte_physiol1.02544477
82MP0008004_abnormal_stomach_pH1.01273545
83MP0003866_abnormal_defecation1.00449373
84MP0005390_skeleton_phenotype1.00221297
85MP0002019_abnormal_tumor_incidence0.96171076
86MP0003091_abnormal_cell_migration0.91040719
87MP0002332_abnormal_exercise_endurance0.90400542
88MP0003075_altered_response_to0.89036092
89MP0000249_abnormal_blood_vessel0.88804505
90MP0009764_decreased_sensitivity_to0.86890697
91MP0008260_abnormal_autophagy0.83816543
92MP0001663_abnormal_digestive_system0.82189060
93MP0008007_abnormal_cellular_replicative0.81859215
94MP0000371_diluted_coat_color0.79616236
95MP0003693_abnormal_embryo_hatching0.78270115
96MP0009763_increased_sensitivity_to0.77379802
97MP0000767_abnormal_smooth_muscle0.76448181
98MP0003828_pulmonary_edema0.76150164
99MP0008874_decreased_physiological_sensi0.76084386
100MP0000920_abnormal_myelination0.73501354
101MP0003329_amyloid_beta_deposits0.73252396
102MP0003795_abnormal_bone_structure0.73183846
103MP0004883_abnormal_blood_vessel0.73146494
104MP0009765_abnormal_xenobiotic_induced0.72151455
105MP0005257_abnormal_intraocular_pressure0.71031291
106MP0001348_abnormal_lacrimal_gland0.69714309
107MP0000598_abnormal_liver_morphology0.69459754
108MP0000313_abnormal_cell_death0.68207286
109MP0005164_abnormal_response_to0.68126532
110MP0003077_abnormal_cell_cycle0.66831194
111MP0005535_abnormal_body_temperature0.66592623
112MP0000733_abnormal_muscle_development0.66366442
113MP0003195_calcinosis0.65894809
114MP0003186_abnormal_redox_activity0.65675155
115MP0001915_intracranial_hemorrhage0.65605198
116MP0003111_abnormal_nucleus_morphology0.65522647
117MP0010368_abnormal_lymphatic_system0.65064012
118MP0003646_muscle_fatigue0.64468789
119MP0000569_abnormal_digit_pigmentation0.63153717
120MP0001879_abnormal_lymphatic_vessel0.62981126
121MP0005275_abnormal_skin_tensile0.60965068
122MP0000604_amyloidosis0.60239879
123MP0003183_abnormal_peptide_metabolism0.59458114
124MP0005647_abnormal_sex_gland0.58901399
125MP0002277_abnormal_respiratory_mucosa0.57768977
126MP0005165_increased_susceptibility_to0.54821335
127MP0005584_abnormal_enzyme/coenzyme_acti0.54146178
128MP0005319_abnormal_enzyme/_coenzyme0.52674360
129MP0005365_abnormal_bile_salt0.50129662
130MP0005334_abnormal_fat_pad0.48188830

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.03015223
2Recurrent abscess formation (HP:0002722)4.97734419
3Recurrent bacterial skin infections (HP:0005406)4.40544777
4Chronic otitis media (HP:0000389)4.28439017
5Elevated erythrocyte sedimentation rate (HP:0003565)4.21686801
6Nasal polyposis (HP:0100582)4.06622017
7Optic neuritis (HP:0100653)3.97796530
8Retrobulbar optic neuritis (HP:0100654)3.97796530
9Abnormality of the nasal mucosa (HP:0000433)3.90536307
10Myositis (HP:0100614)3.84182792
11Vacuolated lymphocytes (HP:0001922)3.47739058
12Abnormality of macrophages (HP:0004311)3.46127222
13Thrombocytosis (HP:0001894)3.45638933
14Recurrent gram-negative bacterial infections (HP:0005420)3.35330915
15Increased cerebral lipofuscin (HP:0011813)3.35070269
16Dysostosis multiplex (HP:0000943)3.26780941
17Recurrent fungal infections (HP:0002841)3.24339214
18Recurrent viral infections (HP:0004429)3.12630266
19Mediastinal lymphadenopathy (HP:0100721)3.12484301
20Cellulitis (HP:0100658)3.04955139
21Disinhibition (HP:0000734)3.04380591
22Mucopolysacchariduria (HP:0008155)3.01920568
23Urinary glycosaminoglycan excretion (HP:0003541)3.01920568
24Petechiae (HP:0000967)2.99291873
25Interstitial pulmonary disease (HP:0006530)2.98978295
26Recurrent skin infections (HP:0001581)2.94416714
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.92095981
28Hemoptysis (HP:0002105)2.88413653
29Peritonitis (HP:0002586)2.87714162
30Pustule (HP:0200039)2.82544147
31Recurrent bronchitis (HP:0002837)2.80593462
32Cerebral aneurysm (HP:0004944)2.80467932
33Abnormality of polysaccharide metabolism (HP:0011012)2.75780918
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75780918
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75780918
36Vertebral compression fractures (HP:0002953)2.73895669
37Mutism (HP:0002300)2.73292685
38Keratoconjunctivitis sicca (HP:0001097)2.72612563
39Loss of speech (HP:0002371)2.70755481
40Spontaneous hematomas (HP:0007420)2.68651361
41Cervical subluxation (HP:0003308)2.65927260
42Keratoconjunctivitis (HP:0001096)2.64184369
43Obstructive lung disease (HP:0006536)2.62711199
44Chronic obstructive pulmonary disease (HP:0006510)2.62711199
45Orchitis (HP:0100796)2.60696175
46Protrusio acetabuli (HP:0003179)2.58166423
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.57794673
48Prolonged bleeding time (HP:0003010)2.55432378
49Systemic lupus erythematosus (HP:0002725)2.54988854
50Gastrointestinal infarctions (HP:0005244)2.51208918
51Autoimmune thrombocytopenia (HP:0001973)2.49454473
52Encephalitis (HP:0002383)2.48694976
53Increased IgM level (HP:0003496)2.44484570
54Abnormality of T cell physiology (HP:0011840)2.41658760
55Abnormality of glycolipid metabolism (HP:0010969)2.41599720
56Abnormality of liposaccharide metabolism (HP:0010968)2.41599720
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.41599720
58Mesangial abnormality (HP:0001966)2.38567536
59Abnormality of B cell number (HP:0010975)2.37837762
60Gingivitis (HP:0000230)2.34414562
61Emphysema (HP:0002097)2.34126492
62Meningitis (HP:0001287)2.31639669
63Abnormal platelet function (HP:0011869)2.30926757
64Impaired platelet aggregation (HP:0003540)2.30926757
65Epistaxis (HP:0000421)2.30279004
66Agammaglobulinemia (HP:0004432)2.28916812
67Periodontitis (HP:0000704)2.28591066
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27042050
69Osteolytic defects of the hand bones (HP:0009699)2.24111942
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.24111942
71Neuronal loss in central nervous system (HP:0002529)2.23723805
72Gastrointestinal inflammation (HP:0004386)2.23668476
73Chronic mucocutaneous candidiasis (HP:0002728)2.22825875
74Recurrent cutaneous fungal infections (HP:0011370)2.22825875
75Gangrene (HP:0100758)2.22721959
76Vasculitis (HP:0002633)2.21956355
77Inflammation of the large intestine (HP:0002037)2.21472941
78Increased IgE level (HP:0003212)2.19853386
79Abnormality of the pleura (HP:0002103)2.19844175
80IgM deficiency (HP:0002850)2.17805376
81Abnormality of the prostate (HP:0008775)2.17631321
82Segmental peripheral demyelination/remyelination (HP:0003481)2.16135916
83Gingival bleeding (HP:0000225)2.15573013
84Increased density of long bones (HP:0006392)2.14463067
85Abnormality of iron homeostasis (HP:0011031)2.14038258
86Joint stiffness (HP:0001387)2.13998863
87Diminished motivation (HP:0000745)2.13751484
88Amyloidosis (HP:0011034)2.13187560
89Apathy (HP:0000741)2.12241524
90Thoracic kyphosis (HP:0002942)2.11558510
91Restrictive lung disease (HP:0002091)2.11206234
92Colitis (HP:0002583)2.10776547
93B lymphocytopenia (HP:0010976)2.10631912
94T lymphocytopenia (HP:0005403)2.10228176
95Granulocytopenia (HP:0001913)2.09280649
96Urticaria (HP:0001025)2.07605701
97Gastrointestinal stroma tumor (HP:0100723)2.07115022
98Osteomyelitis (HP:0002754)2.06186735
99Hypergammaglobulinemia (HP:0010702)2.06040973
100Polyneuropathy (HP:0001271)2.05916649
101Abnormality of T cell number (HP:0011839)2.04504694
102Panhypogammaglobulinemia (HP:0003139)2.04108837
103Leukocytosis (HP:0001974)2.03921135
104Prostate neoplasm (HP:0100787)2.02044950
105Tetraparesis (HP:0002273)2.01791533
106Autoimmune hemolytic anemia (HP:0001890)2.01454870
107Hepatosplenomegaly (HP:0001433)1.99911823
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99037906
109Neurofibrillary tangles (HP:0002185)1.98966579
110Pulmonary embolism (HP:0002204)1.98062818
111Abnormality of T cells (HP:0002843)1.97614536
112Abnormal platelet volume (HP:0011876)1.97226625
113Hematochezia (HP:0002573)1.96951064
114Facial diplegia (HP:0001349)1.96847497
115Thin bony cortex (HP:0002753)1.96725929
116Pulmonary infiltrates (HP:0002113)1.96582336
117Abnormality of cells of the erythroid lineage (HP:0012130)1.96268079
118Metaphyseal irregularity (HP:0003025)1.95879455
119Eosinophilia (HP:0001880)1.94110231
120Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93995812
121Recurrent pneumonia (HP:0006532)1.93990943
122Premature rupture of membranes (HP:0001788)1.93397816
123Arterial thrombosis (HP:0004420)1.93358345
124Purpura (HP:0000979)1.93335776
125Abnormality of the peritoneum (HP:0002585)1.92426205
126Abnormal number of erythroid precursors (HP:0012131)1.92209797
127Basal ganglia calcification (HP:0002135)1.91605736
128Deformed sella turcica (HP:0002681)1.91016560
129J-shaped sella turcica (HP:0002680)1.88958222
130Chronic sinusitis (HP:0011109)1.88763095
131Reticulocytopenia (HP:0001896)1.88290829
132Menorrhagia (HP:0000132)1.84658771
133Chest pain (HP:0100749)1.84155785
134Skin ulcer (HP:0200042)1.84048771
135Abnormality of the thoracic spine (HP:0100711)1.83784391
136Glomerulonephritis (HP:0000099)1.82383732
137Spondylolisthesis (HP:0003302)1.81974049
138Increased serum ferritin (HP:0003281)1.81207913
139Hand muscle atrophy (HP:0009130)1.80824894
140Stomatitis (HP:0010280)1.80298626
141Poor head control (HP:0002421)1.79425609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.57464092
2TRIB33.34275306
3MAP4K13.16261771
4PKN23.00038480
5EEF2K2.72746845
6KIT2.72621872
7PIM22.69648353
8TBK12.60013136
9BLK2.57941970
10TYK22.42778701
11GRK72.13862119
12PRPF4B1.98494679
13JAK31.88243596
14FLT31.83788744
15BMPR21.81792388
16NME21.79466867
17MAP3K101.78300756
18ZAP701.71977498
19FGR1.68771334
20LRRK21.68026436
21BTK1.62943333
22TAOK21.62179653
23BMPR1B1.61132519
24MAP3K141.60595931
25RIPK41.59044164
26MAP2K31.57512181
27TAOK31.54796932
28MAPK151.53460446
29IKBKB1.51253248
30IRAK41.47282805
31IKBKE1.42985808
32KDR1.42527509
33PTK61.41450011
34EPHB11.37940280
35IRAK31.37882401
36ADRBK21.35654688
37TEC1.34964612
38TGFBR21.32948529
39CSF1R1.32180651
40MAP3K111.29672624
41RPS6KA41.27576214
42PIM11.27316754
43STK101.25763065
44JAK11.25365492
45MAP3K131.24581335
46DDR21.21365088
47SIK31.21054383
48SCYL21.20590641
49CSK1.20181693
50TTN1.19730691
51PAK41.13062286
52BMX1.12387952
53IRAK11.09640195
54TNK21.08897164
55SYK1.03888761
56CDK81.00081110
57HCK0.99607569
58TESK10.99493236
59CHUK0.99088005
60GRK60.97040008
61TESK20.96545147
62TGFBR10.96487668
63FES0.96249455
64CDC42BPA0.95657498
65MAPKAPK30.95168296
66MATK0.94062778
67NEK20.94040634
68FGFR40.92391789
69RIPK10.91552040
70TXK0.87761125
71LCK0.85527029
72DYRK1B0.84886436
73LYN0.82922108
74ACVR1B0.82519192
75JAK20.79595104
76CDK120.76495402
77RPS6KB20.76471084
78CDK60.76049810
79MOS0.75386598
80ILK0.72753125
81SIK20.68968782
82MAP3K80.68831042
83ITK0.68729298
84CDK40.68578358
85TLK10.67829472
86CLK10.67584750
87CDK90.65132963
88IRAK20.64183695
89STK40.62884366
90RPS6KA60.62835997
91MAP3K30.61832214
92SIK10.61168123
93TAOK10.61107085
94MAPK120.58735960
95PDK10.58084999
96PDPK10.57914228
97TRPM70.57627195
98DAPK20.56840009
99HIPK20.55476059
100MAP3K50.54687661
101PAK20.53111558
102RPS6KL10.52498927
103RPS6KC10.52498927
104NEK90.51786429
105PASK0.50719801
106PRKG20.50466688
107CDK70.50114751
108TIE10.49749283
109EPHA30.49748378
110PIK3CG0.49494966
111ALK0.46886061
112MAPK70.46192922
113MAP2K60.45826158
114PRKCQ0.45321521
115MAPKAPK20.44292238
116MARK30.43944802
117ABL10.43594763
118ABL20.42927803
119EGFR0.40019147
120PKN10.39616860
121WEE10.39501159
122ICK0.35459117
123MAPK110.34820729
124ATR0.34202163
125MARK20.34187162
126DAPK30.34157379
127CAMK1D0.33921515
128MST1R0.33706295
129BCKDK0.33372973
130MAPK40.33323458
131MAP3K10.32587229
132PRKCD0.29774186
133FYN0.25021834
134RPS6KA50.24399105
135VRK10.22221471

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053202.99797453
2Leishmaniasis_Homo sapiens_hsa051402.76797090
3Other glycan degradation_Homo sapiens_hsa005112.31880564
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.27490784
5Osteoclast differentiation_Homo sapiens_hsa043802.08711036
6Legionellosis_Homo sapiens_hsa051342.02439059
7Antigen processing and presentation_Homo sapiens_hsa046122.01744291
8Staphylococcus aureus infection_Homo sapiens_hsa051501.96930382
9Measles_Homo sapiens_hsa051621.94875352
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.94747608
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91119502
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86216403
13Malaria_Homo sapiens_hsa051441.83549298
14B cell receptor signaling pathway_Homo sapiens_hsa046621.83125122
15Lysosome_Homo sapiens_hsa041421.80140477
16Pertussis_Homo sapiens_hsa051331.70352750
17Shigellosis_Homo sapiens_hsa051311.68835632
18Primary immunodeficiency_Homo sapiens_hsa053401.67657596
19DNA replication_Homo sapiens_hsa030301.66184470
20Asthma_Homo sapiens_hsa053101.65349183
21Toxoplasmosis_Homo sapiens_hsa051451.65171727
22Tuberculosis_Homo sapiens_hsa051521.63158155
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57263442
24Herpes simplex infection_Homo sapiens_hsa051681.57122599
25Ribosome_Homo sapiens_hsa030101.56017044
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.54564856
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54055924
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52328290
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52254154
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50783380
31Acute myeloid leukemia_Homo sapiens_hsa052211.50694301
32* Apoptosis_Homo sapiens_hsa042101.47830733
33Chronic myeloid leukemia_Homo sapiens_hsa052201.40799361
34TNF signaling pathway_Homo sapiens_hsa046681.40233691
35Influenza A_Homo sapiens_hsa051641.39838758
36Allograft rejection_Homo sapiens_hsa053301.37093265
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35317106
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33070694
39* Hematopoietic cell lineage_Homo sapiens_hsa046401.32834992
40* Jak-STAT signaling pathway_Homo sapiens_hsa046301.30078292
41Hepatitis B_Homo sapiens_hsa051611.29614418
42Salmonella infection_Homo sapiens_hsa051321.29030618
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25490938
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24496389
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23706449
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21795216
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20076960
48Small cell lung cancer_Homo sapiens_hsa052221.17694222
49Base excision repair_Homo sapiens_hsa034101.11035300
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10503653
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.09871882
52Viral myocarditis_Homo sapiens_hsa054161.09080767
53Graft-versus-host disease_Homo sapiens_hsa053321.06819549
54Phagosome_Homo sapiens_hsa041451.01414887
55p53 signaling pathway_Homo sapiens_hsa041151.00694527
56Chemokine signaling pathway_Homo sapiens_hsa040620.97708857
57Systemic lupus erythematosus_Homo sapiens_hsa053220.95627852
58Mismatch repair_Homo sapiens_hsa034300.94994060
59Pancreatic cancer_Homo sapiens_hsa052120.94818825
60Amoebiasis_Homo sapiens_hsa051460.94721845
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92095496
62Platelet activation_Homo sapiens_hsa046110.89657065
63* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87396613
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87249190
65Epstein-Barr virus infection_Homo sapiens_hsa051690.86742576
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85244613
67Viral carcinogenesis_Homo sapiens_hsa052030.84826907
68Pentose phosphate pathway_Homo sapiens_hsa000300.84790487
69HTLV-I infection_Homo sapiens_hsa051660.82510484
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80378927
71N-Glycan biosynthesis_Homo sapiens_hsa005100.79277525
72T cell receptor signaling pathway_Homo sapiens_hsa046600.75946665
73Rheumatoid arthritis_Homo sapiens_hsa053230.75370994
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.74805285
75Hepatitis C_Homo sapiens_hsa051600.74079308
76HIF-1 signaling pathway_Homo sapiens_hsa040660.74005479
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.72325757
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71234321
79Dorso-ventral axis formation_Homo sapiens_hsa043200.70859334
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69867807
81Galactose metabolism_Homo sapiens_hsa000520.66425639
82Notch signaling pathway_Homo sapiens_hsa043300.66283948
83VEGF signaling pathway_Homo sapiens_hsa043700.66113551
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65346400
85Collecting duct acid secretion_Homo sapiens_hsa049660.63979426
86Renin-angiotensin system_Homo sapiens_hsa046140.61079779
87Focal adhesion_Homo sapiens_hsa045100.59185351
88Proteoglycans in cancer_Homo sapiens_hsa052050.58521326
89One carbon pool by folate_Homo sapiens_hsa006700.56522217
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.56519169
91Prolactin signaling pathway_Homo sapiens_hsa049170.55463320
92Non-small cell lung cancer_Homo sapiens_hsa052230.54652618
93Bladder cancer_Homo sapiens_hsa052190.54369180
94African trypanosomiasis_Homo sapiens_hsa051430.54112205
95Sphingolipid metabolism_Homo sapiens_hsa006000.51444804
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51369185
97Spliceosome_Homo sapiens_hsa030400.49756596
98Insulin resistance_Homo sapiens_hsa049310.49718248
99Type I diabetes mellitus_Homo sapiens_hsa049400.48798862
100MicroRNAs in cancer_Homo sapiens_hsa052060.47938301
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47914731
102Cell cycle_Homo sapiens_hsa041100.46175837
103Proteasome_Homo sapiens_hsa030500.44893291
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.44372834
105Colorectal cancer_Homo sapiens_hsa052100.43401680
106Sulfur relay system_Homo sapiens_hsa041220.43248180
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41023549
108Endocytosis_Homo sapiens_hsa041440.40920735
109ECM-receptor interaction_Homo sapiens_hsa045120.39078951
110Pyrimidine metabolism_Homo sapiens_hsa002400.37251689
111Prion diseases_Homo sapiens_hsa050200.35496753
112Fructose and mannose metabolism_Homo sapiens_hsa000510.33649522
113Complement and coagulation cascades_Homo sapiens_hsa046100.32803119
114Type II diabetes mellitus_Homo sapiens_hsa049300.29995860
115MAPK signaling pathway_Homo sapiens_hsa040100.21661063
116Ether lipid metabolism_Homo sapiens_hsa005650.20907548
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18840387
118PPAR signaling pathway_Homo sapiens_hsa033200.18565330
119Mineral absorption_Homo sapiens_hsa049780.17502340
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.16231328
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16097240
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15711777
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15076749
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.13229612
125Arachidonic acid metabolism_Homo sapiens_hsa005900.09548881
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.08354487
127Ovarian steroidogenesis_Homo sapiens_hsa049130.08012166

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