IL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)9.13538812
2regulation of granulocyte differentiation (GO:0030852)8.41271630
3* positive regulation of immunoglobulin production (GO:0002639)7.26460815
4positive regulation of interleukin-17 production (GO:0032740)7.17602995
5regulation of regulatory T cell differentiation (GO:0045589)7.02773222
6kinetochore assembly (GO:0051382)6.30593426
7positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)6.29802285
8regulation of natural killer cell differentiation (GO:0032823)6.18664555
9* positive regulation of B cell proliferation (GO:0030890)6.14345660
10* regulation of immunoglobulin production (GO:0002637)5.95533513
11positive regulation of organelle assembly (GO:1902117)5.92877947
12muscle organ morphogenesis (GO:0048644)5.83099824
13regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)5.71698140
14positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.68826255
15kinetochore organization (GO:0051383)5.61100528
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.40430455
17positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.30020940
18positive regulation of natural killer cell mediated immunity (GO:0002717)5.25934394
19negative regulation of B cell proliferation (GO:0030889)5.19020115
20* positive regulation of production of molecular mediator of immune response (GO:0002702)4.88245906
21phospholipid scrambling (GO:0017121)4.84551287
22* positive regulation of B cell activation (GO:0050871)4.69549986
23positive regulation of natural killer cell activation (GO:0032816)4.55195920
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.38812338
25regulation of natural killer cell mediated immunity (GO:0002715)4.38812338
26neuron cell-cell adhesion (GO:0007158)4.38438060
27* regulation of chronic inflammatory response (GO:0002676)4.34010444
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.29062075
29* regulation of B cell proliferation (GO:0030888)4.24943209
30tolerance induction (GO:0002507)4.19663505
31response to inactivity (GO:0014854)4.18155548
32* regulation of MHC class II biosynthetic process (GO:0045346)4.16113833
33postsynaptic membrane organization (GO:0001941)4.10959430
34regulation of interleukin-17 production (GO:0032660)4.07137532
35* negative regulation of nitric oxide biosynthetic process (GO:0045019)4.07006808
36negative regulation of B cell activation (GO:0050869)4.05916493
37mucosal-associated lymphoid tissue development (GO:0048537)4.03367965
38Peyers patch development (GO:0048541)4.03367965
39regulation of interferon-gamma biosynthetic process (GO:0045072)4.00734816
40termination of RNA polymerase I transcription (GO:0006363)4.00499159
41cellular response to interleukin-15 (GO:0071350)4.00281407
42chaperone-mediated protein transport (GO:0072321)3.93767906
43regulation of cAMP-dependent protein kinase activity (GO:2000479)3.93276517
44* regulation of production of molecular mediator of immune response (GO:0002700)3.92805704
45* CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.91806248
46* T-helper cell differentiation (GO:0042093)3.91806248
47platelet dense granule organization (GO:0060155)3.90561462
48* positive regulation of JAK-STAT cascade (GO:0046427)3.84826286
49negative regulation of immunoglobulin mediated immune response (GO:0002890)3.84253719
50negative regulation of B cell mediated immunity (GO:0002713)3.84253719
51positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.81026598
52* positive regulation of interleukin-10 production (GO:0032733)3.75312711
53regulation of synaptic vesicle exocytosis (GO:2000300)3.71628362
54* regulation of B cell activation (GO:0050864)3.67377733
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.67315472
56mitochondrial RNA metabolic process (GO:0000959)3.62534946
57regulation of leukocyte mediated cytotoxicity (GO:0001910)3.61870424
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61503218
59negative T cell selection (GO:0043383)3.57404024
60chemokine-mediated signaling pathway (GO:0070098)3.56330302
61cell wall macromolecule catabolic process (GO:0016998)3.54084562
62GTP biosynthetic process (GO:0006183)3.53006480
63positive regulation of humoral immune response (GO:0002922)3.52689108
64regulation of vitamin D biosynthetic process (GO:0060556)3.48796910
65synaptic vesicle exocytosis (GO:0016079)3.45579952
66* alpha-beta T cell differentiation involved in immune response (GO:0002293)3.45199582
67* alpha-beta T cell activation involved in immune response (GO:0002287)3.45199582
68* T cell differentiation involved in immune response (GO:0002292)3.45199582
69regulation of cytokine secretion involved in immune response (GO:0002739)3.44694219
70vocalization behavior (GO:0071625)3.44588739
71imidazole-containing compound metabolic process (GO:0052803)3.42594640
72regulation of T cell tolerance induction (GO:0002664)3.39870233
73response to interleukin-15 (GO:0070672)3.39569358
74negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.38176044
75positive regulation of myeloid leukocyte differentiation (GO:0002763)3.36800146
76UTP biosynthetic process (GO:0006228)3.31344047
77regulation of interleukin-2 biosynthetic process (GO:0045076)3.30373281
78regulation of synaptic vesicle transport (GO:1902803)3.29311076
79regulation of natural killer cell activation (GO:0032814)3.29304574
80regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29046576
81removal of superoxide radicals (GO:0019430)3.28150978
82cellular response to superoxide (GO:0071451)3.28150978
83cellular response to oxygen radical (GO:0071450)3.28150978
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.27634415
85negative regulation of interleukin-12 production (GO:0032695)3.27414922
86negative regulation of cell killing (GO:0031342)3.26955392
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.26955392
88negative regulation of T cell differentiation in thymus (GO:0033085)3.23432770
89definitive hemopoiesis (GO:0060216)3.21774794
90regulation of inflammatory response to antigenic stimulus (GO:0002861)3.19114983
91* regulation of isotype switching to IgG isotypes (GO:0048302)3.18398942
92motile cilium assembly (GO:0044458)3.17178484
93natural killer cell differentiation (GO:0001779)3.16917808
94protein localization to synapse (GO:0035418)3.16665348
95glutamate secretion (GO:0014047)3.16447669
96negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16044254
97positive regulation of cell killing (GO:0031343)3.15987660
98regulation of cell killing (GO:0031341)3.14508441
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14148558
100positive regulation of neurotransmitter secretion (GO:0001956)3.13284742
101* regulation of lymphocyte mediated immunity (GO:0002706)3.13036316
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12290406
103meiotic chromosome segregation (GO:0045132)3.11117505
104ribosome assembly (GO:0042255)3.10732603
105negative thymic T cell selection (GO:0045060)3.10281356
106* positive regulation of lymphocyte mediated immunity (GO:0002708)3.09714595
107negative regulation of neurotransmitter transport (GO:0051589)3.09330355
108presynaptic membrane assembly (GO:0097105)3.08263820
109* CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.07431552
110neuronal action potential propagation (GO:0019227)3.07326110
111negative regulation of type 2 immune response (GO:0002829)3.05927498
112T cell apoptotic process (GO:0070231)3.05711597
113DNA replication-dependent nucleosome organization (GO:0034723)3.02638412
114DNA replication-dependent nucleosome assembly (GO:0006335)3.02638412
115purine-containing compound salvage (GO:0043101)3.00545990
116piRNA metabolic process (GO:0034587)3.00335770
117* positive regulation of leukocyte mediated immunity (GO:0002705)2.98481734
118negative regulation of T cell mediated immunity (GO:0002710)2.96757779
119natural killer cell mediated immunity (GO:0002228)2.96695198
120natural killer cell mediated cytotoxicity (GO:0042267)2.96695198
121presynaptic membrane organization (GO:0097090)2.96415905
122activation of protein kinase A activity (GO:0034199)2.95773137
123* regulation of isotype switching (GO:0045191)2.94911161
124response to cadmium ion (GO:0046686)2.93885869
125cellular biogenic amine biosynthetic process (GO:0042401)2.92676286
126regulation of glutamate receptor signaling pathway (GO:1900449)2.90974676
127cell wall macromolecule metabolic process (GO:0044036)2.90320472
128positive regulation of neurotransmitter transport (GO:0051590)2.88942335
129UTP metabolic process (GO:0046051)2.87354488
130response to superoxide (GO:0000303)2.86798940
131* positive regulation of isotype switching (GO:0045830)2.86099589
132catecholamine transport (GO:0051937)2.84497934
133synaptic transmission, glutamatergic (GO:0035249)2.83945747
134fucose catabolic process (GO:0019317)2.83699397
135L-fucose metabolic process (GO:0042354)2.83699397
136L-fucose catabolic process (GO:0042355)2.83699397
137neurotransmitter-gated ion channel clustering (GO:0072578)2.83522071
138regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81676234
139replication fork processing (GO:0031297)2.81377561
140DNA methylation involved in gamete generation (GO:0043046)2.80947431
141* negative regulation of adaptive immune response (GO:0002820)2.80474239
142* regulation of JAK-STAT cascade (GO:0046425)2.80054788
143regulation of double-strand break repair via homologous recombination (GO:0010569)2.79887087
144* positive regulation of DNA recombination (GO:0045911)2.79652367
145regulation of tolerance induction (GO:0002643)2.78984141
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78850424
147* positive regulation of immune effector process (GO:0002699)2.78696720
148catechol-containing compound biosynthetic process (GO:0009713)2.78578758
149catecholamine biosynthetic process (GO:0042423)2.78578758
150interferon-gamma production (GO:0032609)2.78437471
151* CD4-positive, alpha-beta T cell activation (GO:0035710)2.77014975
152ionotropic glutamate receptor signaling pathway (GO:0035235)2.75482378
153synaptic vesicle maturation (GO:0016188)2.74334540
154T cell receptor signaling pathway (GO:0050852)2.73072338
155negative regulation of lymphocyte mediated immunity (GO:0002707)2.72932228
156antigen receptor-mediated signaling pathway (GO:0050851)2.72274577
157T cell costimulation (GO:0031295)2.71585059
158* lymphocyte costimulation (GO:0031294)2.71585059
159positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70456693
160positive regulation of granulocyte differentiation (GO:0030854)2.69476464
161regulation of defense response to virus by virus (GO:0050690)2.69168692
162glial cell proliferation (GO:0014009)2.68809863
163neuron-neuron synaptic transmission (GO:0007270)2.66462688
164regulation of B cell receptor signaling pathway (GO:0050855)2.66259854
165regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65504606
166cytoplasmic sequestering of transcription factor (GO:0042994)2.65469300
167branching involved in labyrinthine layer morphogenesis (GO:0060670)2.65048095
168secretory granule organization (GO:0033363)2.61925943
169neurotransmitter secretion (GO:0007269)2.60764995
170negative regulation of nitric-oxide synthase activity (GO:0051001)2.59231483
171regulation of neurotransmitter secretion (GO:0046928)2.58928826
172positive regulation of lymphocyte apoptotic process (GO:0070230)2.55442397
173negative regulation of blood circulation (GO:1903523)2.55401569
174regulation of T cell receptor signaling pathway (GO:0050856)2.54207651
175negative regulation of production of molecular mediator of immune response (GO:0002701)2.53994812
176* negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.52390302
177heparin metabolic process (GO:0030202)2.51633649
178heparin biosynthetic process (GO:0030210)2.51633649
179positive T cell selection (GO:0043368)2.49781421
180negative regulation of neurotransmitter secretion (GO:0046929)2.49009985
181regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48622035
182leukocyte aggregation (GO:0070486)2.47241394
183positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.45955292
184neurotransmitter uptake (GO:0001504)2.45441057
185startle response (GO:0001964)2.44951348
186dopamine transport (GO:0015872)2.44149940
187positive regulation of filopodium assembly (GO:0051491)2.42740158
188endosome to melanosome transport (GO:0035646)2.41983436
189endosome to pigment granule transport (GO:0043485)2.41983436
190signal peptide processing (GO:0006465)2.40024483
191negative regulation of T cell proliferation (GO:0042130)2.39850597
192regulation of excitatory postsynaptic membrane potential (GO:0060079)2.39457525
193regulation of podosome assembly (GO:0071801)14.9526465
194regulation of immunoglobulin secretion (GO:0051023)11.6420517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.96981687
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.68969399
3GBX2_23144817_ChIP-Seq_PC3_Human4.50680285
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16081437
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.11429545
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86655322
7EZH2_22144423_ChIP-Seq_EOC_Human3.84575827
8TAF15_26573619_Chip-Seq_HEK293_Human3.49312756
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.46904893
10IKZF1_21737484_ChIP-ChIP_HCT116_Human3.05763444
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.05639411
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98422349
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90847801
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.52230744
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.45413109
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.42417333
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38927231
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31253854
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28160214
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28043404
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12053006
22RUNX_20019798_ChIP-Seq_JUKART_Human2.09108637
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06524600
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06435222
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99254539
26* REST_21632747_ChIP-Seq_MESCs_Mouse1.98114752
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92962542
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92072648
29SCL_19346495_ChIP-Seq_HPC-7_Human1.92004813
30IRF1_19129219_ChIP-ChIP_H3396_Human1.90876913
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90621126
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88597731
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.86725400
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85807857
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84746042
36* MYB_26560356_Chip-Seq_TH2_Human1.80795354
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78671569
38P300_19829295_ChIP-Seq_ESCs_Human1.76838684
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74148585
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67114048
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66634122
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.62870976
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62147947
44TP53_22573176_ChIP-Seq_HFKS_Human1.61482855
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61380585
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61105386
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58421089
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58168238
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56658200
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56603891
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56370455
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54036895
53VDR_23849224_ChIP-Seq_CD4+_Human1.53521093
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52824536
55SMAD4_21799915_ChIP-Seq_A2780_Human1.52770511
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.52415232
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51011614
58FOXP3_21729870_ChIP-Seq_TREG_Human1.50580746
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49711836
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.49511363
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49506013
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.48332603
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.48100389
64FUS_26573619_Chip-Seq_HEK293_Human1.46282465
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44292848
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42889851
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42889851
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41914673
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41339032
70GATA1_22025678_ChIP-Seq_K562_Human1.40693701
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40242736
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40222399
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.38100696
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35359038
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34896824
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34201672
77MYC_18940864_ChIP-ChIP_HL60_Human1.33726409
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32858129
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31627697
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27841856
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.26801697
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23200586
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22368093
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20318631
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.19053332
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19030670
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18842269
88DROSHA_22980978_ChIP-Seq_HELA_Human1.17779680
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17619945
90AR_21572438_ChIP-Seq_LNCaP_Human1.16536802
91RNF2_27304074_Chip-Seq_NSC_Mouse1.16050096
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15877708
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15866394
94EWS_26573619_Chip-Seq_HEK293_Human1.15347262
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14961344
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13080860
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.12848623
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12627173
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.11885043
100* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11780292
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11327074
102TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10348833
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.10325742
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09916232
105AR_25329375_ChIP-Seq_VCAP_Human1.09377939
106IGF1R_20145208_ChIP-Seq_DFB_Human1.07372425
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07117222
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06876784
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05925186
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.05097176
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05048849
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04544920
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.03016347
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02964406
115GATA3_26560356_Chip-Seq_TH1_Human1.02385164
116GATA3_27048872_Chip-Seq_THYMUS_Human1.01778484
117KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01120047
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00422468
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99783093
120ZNF274_21170338_ChIP-Seq_K562_Hela0.99762753
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98431647
122NANOG_20526341_ChIP-Seq_ESCs_Human0.98374941
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97666648
124EED_16625203_ChIP-ChIP_MESCs_Mouse0.97659335
125* GATA3_26560356_Chip-Seq_TH2_Human0.97201463
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.95978379
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.95845839
128* GATA1_19941827_ChIP-Seq_MEL_Mouse0.93956338
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93905168
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.92868643
131ERG_20517297_ChIP-Seq_VCAP_Human0.92172437
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91681942
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.91658828
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91642430
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90986845
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90965425
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90440618
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90151861
139P53_22387025_ChIP-Seq_ESCs_Mouse0.90124125
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.90077439
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.89859720
142SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88746416
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87850536
144CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87675804
145BCAT_22108803_ChIP-Seq_LS180_Human0.87586121
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87027657
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86904773
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86551878
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86548288
150SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86285418
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84262016
152VDR_24787735_ChIP-Seq_THP-1_Human0.84110789
153PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83580644
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81442478
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81081109
156SALL4_22934838_ChIP-ChIP_CD34+_Human0.79326312
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.79184760
158FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79184760
159TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78930393
160MYB_26560356_Chip-Seq_TH1_Human0.76730595
161MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75714368
162CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75690411
163RBPJ_21746931_ChIP-Seq_IB4_Human0.73862001
164E2F4_17652178_ChIP-ChIP_JURKAT_Human0.73426108
165* TAF2_19829295_ChIP-Seq_ESCs_Human0.73314333
166SMRT_27268052_Chip-Seq_Bcells_Human0.72632389
167GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72282247
168CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71803373
169ELK1_19687146_ChIP-ChIP_HELA_Human0.70341601
170IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.67996511
171CBP_20019798_ChIP-Seq_JUKART_Human0.67996511
172FOXH1_21741376_ChIP-Seq_EPCs_Human0.67841289
173MAF_26560356_Chip-Seq_TH2_Human0.67121396
174TTF2_22483619_ChIP-Seq_HELA_Human0.67112747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.57401198
2MP0003718_maternal_effect3.85435040
3MP0003880_abnormal_central_pattern3.59593755
4MP0005671_abnormal_response_to3.43819606
5MP0004742_abnormal_vestibular_system3.36844258
6MP0003303_peritoneal_inflammation3.17701315
7MP0004859_abnormal_synaptic_plasticity3.01483925
8MP0004510_myositis2.99079136
9MP0002332_abnormal_exercise_endurance2.90879042
10MP0002009_preneoplasia2.80859163
11MP0001188_hyperpigmentation2.79641922
12MP0002138_abnormal_hepatobiliary_system2.65684743
13MP0003635_abnormal_synaptic_transmissio2.56788352
14MP0009333_abnormal_splenocyte_physiolog2.53482086
15MP0009745_abnormal_behavioral_response2.49010257
16MP0009840_abnormal_foam_cell2.47685030
17MP0002733_abnormal_thermal_nociception2.45293750
18MP0001501_abnormal_sleep_pattern2.43301955
19* MP0005310_abnormal_salivary_gland2.40631691
20MP0001968_abnormal_touch/_nociception2.39209591
21MP0002735_abnormal_chemical_nociception2.36574961
22MP0001853_heart_inflammation2.33032295
23MP0002166_altered_tumor_susceptibility2.31422442
24MP0003763_abnormal_thymus_physiology2.24006028
25MP0004381_abnormal_hair_follicle2.18958936
26MP0009046_muscle_twitch2.18150040
27MP0002064_seizures2.18022271
28MP0003436_decreased_susceptibility_to2.14651390
29MP0003646_muscle_fatigue2.13983628
30MP0008877_abnormal_DNA_methylation2.11808140
31MP0001970_abnormal_pain_threshold2.08072566
32MP0002006_tumorigenesis2.04522997
33MP0002736_abnormal_nociception_after2.04222868
34MP0002572_abnormal_emotion/affect_behav1.96724949
35MP0004270_analgesia1.93568929
36MP0006276_abnormal_autonomic_nervous1.91858230
37MP0002063_abnormal_learning/memory/cond1.90477734
38MP0003300_gastrointestinal_ulcer1.89212356
39MP0002272_abnormal_nervous_system1.88159533
40MP0008058_abnormal_DNA_repair1.86645931
41MP0001502_abnormal_circadian_rhythm1.85613596
42MP0005451_abnormal_body_composition1.84396211
43MP0002734_abnormal_mechanical_nocicepti1.83301985
44MP0008057_abnormal_DNA_replication1.78228529
45MP0009785_altered_susceptibility_to1.65888745
46* MP0001873_stomach_inflammation1.64776951
47MP0001486_abnormal_startle_reflex1.64533496
48MP0001984_abnormal_olfaction1.52828302
49MP0002638_abnormal_pupillary_reflex1.52510114
50MP0003724_increased_susceptibility_to1.51370943
51MP0008569_lethality_at_weaning1.51201306
52* MP0001835_abnormal_antigen_presentation1.50261851
53MP0001905_abnormal_dopamine_level1.46735640
54MP0003045_fibrosis1.46641108
55MP0005645_abnormal_hypothalamus_physiol1.44573646
56MP0003787_abnormal_imprinting1.43653257
57MP0000465_gastrointestinal_hemorrhage1.43510573
58MP0005395_other_phenotype1.42747075
59MP0002067_abnormal_sensory_capabilities1.41447167
60MP0004145_abnormal_muscle_electrophysio1.35475294
61MP0006292_abnormal_olfactory_placode1.33798061
62* MP0001800_abnormal_humoral_immune1.32804565
63MP0004142_abnormal_muscle_tone1.32749001
64MP0004811_abnormal_neuron_physiology1.31195860
65MP0002822_catalepsy1.30492835
66* MP0005000_abnormal_immune_tolerance1.30318224
67MP0005423_abnormal_somatic_nervous1.30017151
68MP0008789_abnormal_olfactory_epithelium1.29675124
69MP0000569_abnormal_digit_pigmentation1.28986324
70MP0002277_abnormal_respiratory_mucosa1.28797679
71MP0001529_abnormal_vocalization1.28253895
72MP0005464_abnormal_platelet_physiology1.24892973
73MP0005646_abnormal_pituitary_gland1.24134721
74* MP0008469_abnormal_protein_level1.23617431
75MP0001881_abnormal_mammary_gland1.23557423
76* MP0002723_abnormal_immune_serum1.18523290
77* MP0005387_immune_system_phenotype1.17779748
78* MP0001790_abnormal_immune_system1.17779748
79MP0005386_behavior/neurological_phenoty1.17233647
80MP0004924_abnormal_behavior1.17233647
81MP0000372_irregular_coat_pigmentation1.16495367
82MP0003186_abnormal_redox_activity1.16098585
83MP0002184_abnormal_innervation1.14676279
84* MP0005025_abnormal_response_to1.13634943
85MP0003866_abnormal_defecation1.13178128
86* MP0002429_abnormal_blood_cell1.13004909
87MP0004147_increased_porphyrin_level1.12134850
88MP0005408_hypopigmentation1.12104516
89* MP0002398_abnormal_bone_marrow1.11957037
90MP0002102_abnormal_ear_morphology1.11486516
91* MP0001819_abnormal_immune_cell1.10041079
92* MP0002420_abnormal_adaptive_immunity1.09765938
93MP0008874_decreased_physiological_sensi1.09627948
94MP0001440_abnormal_grooming_behavior1.09507114
95MP0003699_abnormal_female_reproductive1.09178245
96MP0003075_altered_response_to1.09008979
97MP0002148_abnormal_hypersensitivity_rea1.08832262
98MP0009697_abnormal_copulation1.07802360
99MP0001765_abnormal_ion_homeostasis1.05469417
100MP0002210_abnormal_sex_determination1.04914276
101MP0005535_abnormal_body_temperature1.03995050
102MP0002933_joint_inflammation1.03181073
103MP0005448_abnormal_energy_balance1.02484566
104MP0002557_abnormal_social/conspecific_i1.01907408
105MP0010155_abnormal_intestine_physiology0.99195853
106MP0003122_maternal_imprinting0.98876072
107* MP0002452_abnormal_antigen_presenting0.98317216
108MP0001986_abnormal_taste_sensitivity0.96535537
109MP0004484_altered_response_of0.94043369
110MP0002095_abnormal_skin_pigmentation0.93682278
111MP0005085_abnormal_gallbladder_physiolo0.92968569
112MP0000427_abnormal_hair_cycle0.92861096
113MP0000778_abnormal_nervous_system0.91435999
114MP0005409_darkened_coat_color0.90780402
115* MP0000716_abnormal_immune_system0.89702653
116* MP0001663_abnormal_digestive_system0.89585905
117MP0004084_abnormal_cardiac_muscle0.89469747
118MP0005165_increased_susceptibility_to0.88069934
119MP0003191_abnormal_cellular_cholesterol0.87452052
120* MP0008872_abnormal_physiological_respon0.87381174
121MP0003633_abnormal_nervous_system0.85869244
122MP0003252_abnormal_bile_duct0.85552712
123MP0005360_urolithiasis0.85224089
124MP0000685_abnormal_immune_system0.84751646
125MP0002234_abnormal_pharynx_morphology0.84616262
126MP0001919_abnormal_reproductive_system0.84403992
127MP0003879_abnormal_hair_cell0.83504337
128MP0002066_abnormal_motor_capabilities/c0.83104332
129MP0005499_abnormal_olfactory_system0.82286074
130MP0005394_taste/olfaction_phenotype0.82286074
131MP0005410_abnormal_fertilization0.82282605
132MP0002405_respiratory_system_inflammati0.82055333
133MP0003943_abnormal_hepatobiliary_system0.80013226
134MP0005075_abnormal_melanosome_morpholog0.79730864
135MP0000703_abnormal_thymus_morphology0.79470031
136MP0001243_abnormal_dermal_layer0.79013430
137MP0002882_abnormal_neuron_morphology0.78518938
138MP0002909_abnormal_adrenal_gland0.78197042
139MP0005389_reproductive_system_phenotype0.77335961
140MP0002163_abnormal_gland_morphology0.76506283
141MP0002722_abnormal_immune_system0.75830547
142MP0003567_abnormal_fetal_cardiomyocyte0.74643629
143MP0004808_abnormal_hematopoietic_stem0.74616244
144* MP0000477_abnormal_intestine_morphology0.74142785
145MP0005167_abnormal_blood-brain_barrier0.73833296
146MP0009765_abnormal_xenobiotic_induced0.72490039
147MP0000689_abnormal_spleen_morphology0.72427406
148MP0004947_skin_inflammation0.72384510
149MP0003950_abnormal_plasma_membrane0.72087222
150* MP0001845_abnormal_inflammatory_respons0.71949744
151MP0003221_abnormal_cardiomyocyte_apopto0.71646878
152MP0005636_abnormal_mineral_homeostasis0.70282908
153* MP0002419_abnormal_innate_immunity0.67835063
154MP0006072_abnormal_retinal_apoptosis0.66332698
155MP0001929_abnormal_gametogenesis0.64239930
156MP0002139_abnormal_hepatobiliary_system0.63894164
157MP0002019_abnormal_tumor_incidence0.63452915
158MP0008873_increased_physiological_sensi0.61251877
159MP0003136_yellow_coat_color0.61126763
160MP0000627_abnormal_mammary_gland0.59753758
161MP0003077_abnormal_cell_cycle0.59528828

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)6.85663782
2Retrobulbar optic neuritis (HP:0100654)6.35081492
3Optic neuritis (HP:0100653)6.35081492
4Large for gestational age (HP:0001520)5.78762853
5Orchitis (HP:0100796)5.29321915
6Myositis (HP:0100614)4.68332291
7Scanning speech (HP:0002168)4.27159840
8Abnormality of the prostate (HP:0008775)4.26597438
9Fibular aplasia (HP:0002990)4.20537891
10Focal motor seizures (HP:0011153)4.18843690
11Febrile seizures (HP:0002373)4.12318814
12Exertional dyspnea (HP:0002875)4.09732574
13Absent/shortened dynein arms (HP:0200106)4.07946500
14Dynein arm defect of respiratory motile cilia (HP:0012255)4.07946500
15Aplasia/Hypoplasia of the ulna (HP:0006495)4.07011537
16Keratoconjunctivitis sicca (HP:0001097)3.91444119
17Pulmonary infiltrates (HP:0002113)3.89942415
18Gangrene (HP:0100758)3.87354218
19Abnormal pupillary function (HP:0007686)3.84437945
20Hypoplasia of the ulna (HP:0003022)3.80593569
21Keratoconjunctivitis (HP:0001096)3.64246959
22Aplastic anemia (HP:0001915)3.61637930
23Pulmonary embolism (HP:0002204)3.53222452
24Arterial thrombosis (HP:0004420)3.51487563
25Limb hypertonia (HP:0002509)3.46823767
26Increased hepatocellular lipid droplets (HP:0006565)3.43378810
27Hemoptysis (HP:0002105)3.36586220
28B lymphocytopenia (HP:0010976)3.31440587
29Abnormality of B cell number (HP:0010975)3.31440587
30Short tibia (HP:0005736)3.28763723
31Inflammation of the large intestine (HP:0002037)3.23845966
32Cerebral hemorrhage (HP:0001342)3.18325030
33Epileptic encephalopathy (HP:0200134)3.16935384
34Aplasia/Hypoplasia of the tibia (HP:0005772)3.15953494
35Lipid accumulation in hepatocytes (HP:0006561)3.14345154
36Obstructive lung disease (HP:0006536)3.13364169
37Chronic obstructive pulmonary disease (HP:0006510)3.13364169
38Abnormality of binocular vision (HP:0011514)3.10873385
39Diplopia (HP:0000651)3.10873385
40Renal Fanconi syndrome (HP:0001994)3.08793596
41Chest pain (HP:0100749)3.07849099
42Vasculitis (HP:0002633)3.02779724
43T lymphocytopenia (HP:0005403)3.00653425
44Hypothermia (HP:0002045)3.00637912
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97993435
46Respiratory difficulties (HP:0002880)2.93548293
47Nasal polyposis (HP:0100582)2.93450256
48Adactyly (HP:0009776)2.92347507
49Deep philtrum (HP:0002002)2.91588375
50Gastrointestinal inflammation (HP:0004386)2.91514862
51Colon cancer (HP:0003003)2.91509562
52Atonic seizures (HP:0010819)2.90190276
53Epistaxis (HP:0000421)2.79025344
54Abnormality of T cell number (HP:0011839)2.78545404
55Prolonged bleeding time (HP:0003010)2.73675490
56Forearm undergrowth (HP:0009821)2.72611192
57IgM deficiency (HP:0002850)2.71850534
58Glomerulopathy (HP:0100820)2.70282237
59Progressive muscle weakness (HP:0003323)2.68803648
60Pendular nystagmus (HP:0012043)2.68265651
61Ureteral stenosis (HP:0000071)2.67567459
62Progressive cerebellar ataxia (HP:0002073)2.66665863
63Abnormal hair whorl (HP:0010721)2.65479945
64Thrombophlebitis (HP:0004418)2.63670463
65Myokymia (HP:0002411)2.61053613
66Paralysis (HP:0003470)2.60614328
67Polyneuropathy (HP:0001271)2.59165267
68Radial bowing (HP:0002986)2.58472025
69Postural instability (HP:0002172)2.57540587
70Primitive neuroectodermal tumor (HP:0030065)2.57415111
71Neuroblastic tumors (HP:0004376)2.57415111
72Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.57415111
73Neuroblastoma (HP:0003006)2.57415111
74Neuroendocrine neoplasm (HP:0100634)2.52121226
75Severe combined immunodeficiency (HP:0004430)2.51815688
76Spinal cord compression (HP:0002176)2.50861201
77Hyperventilation (HP:0002883)2.49907792
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49789071
79Progressive inability to walk (HP:0002505)2.49652410
80Focal seizures (HP:0007359)2.49468109
81Male infertility (HP:0003251)2.47765556
82Gaze-evoked nystagmus (HP:0000640)2.45817310
83Meningitis (HP:0001287)2.41934308
84Abnormality of the nasal mucosa (HP:0000433)2.41806258
85Megalencephaly (HP:0001355)2.41574006
86Humeroradial synostosis (HP:0003041)2.40009972
87Synostosis involving the elbow (HP:0003938)2.40009972
88Ureteral obstruction (HP:0006000)2.39703160
89Ragged-red muscle fibers (HP:0003200)2.37436386
90Paresthesia (HP:0003401)2.34299014
91Thyroiditis (HP:0100646)2.33253827
92Visual hallucinations (HP:0002367)2.32592876
93Abnormal ciliary motility (HP:0012262)2.30857698
94Abnormality of T cells (HP:0002843)2.29871822
95Ependymoma (HP:0002888)2.29805107
96Amaurosis fugax (HP:0100576)2.28777794
97Delayed CNS myelination (HP:0002188)2.28188379
98Type 2 muscle fiber atrophy (HP:0003554)2.27882962
99Abnormal respiratory motile cilium morphology (HP:0005938)2.27207820
100Abnormal respiratory epithelium morphology (HP:0012253)2.27207820
101Abnormality of the pericardium (HP:0001697)2.25800019
1023-Methylglutaconic aciduria (HP:0003535)2.25464264
103Acute necrotizing encephalopathy (HP:0006965)2.24940376
104Medial flaring of the eyebrow (HP:0010747)2.23684397
105Poor eye contact (HP:0000817)2.20642934
106Urticaria (HP:0001025)2.20559792
107Stomatitis (HP:0010280)2.20307129
108Pheochromocytoma (HP:0002666)2.19487862
109Thrombocytosis (HP:0001894)2.18059743
110Gastrointestinal infarctions (HP:0005244)2.18004725
111Abnormality of the phalanges of the 2nd finger (HP:0009541)2.16976713
112Abnormality of male internal genitalia (HP:0000022)2.16709539
113Truncal ataxia (HP:0002078)2.16288175
114Abnormality of the pleura (HP:0002103)2.15863008
115Encephalitis (HP:0002383)2.15154712
116Menstrual irregularities (HP:0000858)2.13215085
117Oral leukoplakia (HP:0002745)2.12782140
118Somatic mutation (HP:0001428)2.12283829
119Progressive microcephaly (HP:0000253)2.11902897
120Cavernous hemangioma (HP:0001048)2.08782844
121Carpal synostosis (HP:0009702)2.07483283
122Increased CSF lactate (HP:0002490)2.06719566
123Vertigo (HP:0002321)2.06449698
124Pulmonary fibrosis (HP:0002206)2.05957663
125Impaired platelet aggregation (HP:0003540)2.05424322
126Abnormal platelet function (HP:0011869)2.05424322
127Increased intramyocellular lipid droplets (HP:0012240)2.05206532
128Abnormal rod and cone electroretinograms (HP:0008323)2.04519923
129IgG deficiency (HP:0004315)2.04489261
130Muscle fiber atrophy (HP:0100295)2.03105359
131Increased serum lactate (HP:0002151)2.03037430
132Limb dystonia (HP:0002451)2.02846354
133Abnormality of the proximal phalanges of the hand (HP:0009834)2.01551400
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01344829
135Short 1st metacarpal (HP:0010034)2.00734202
136Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.00734202
137Aplasia/hypoplasia of the uterus (HP:0008684)1.97885612
138Enlarged epiphyses (HP:0010580)1.97655070
139Bilateral sensorineural hearing impairment (HP:0008619)1.96933063
140Poor suck (HP:0002033)1.96105269
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.94596162
142Abnormality of abdominal situs (HP:0011620)1.94291947
143Abdominal situs inversus (HP:0003363)1.94291947
144Elevated erythrocyte sedimentation rate (HP:0003565)1.93290334
145Supernumerary spleens (HP:0009799)1.92781211
146Abnormality of eosinophils (HP:0001879)1.92079121
147Genetic anticipation (HP:0003743)1.91287519
148Inability to walk (HP:0002540)1.89191177
149Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88942814
150Autoimmune hemolytic anemia (HP:0001890)1.88749557
151Aplasia/hypoplasia of the humerus (HP:0006507)1.88509025
152Hypercalciuria (HP:0002150)1.87555794
153Generalized tonic-clonic seizures (HP:0002069)1.86336206
154Fatigue (HP:0012378)1.85493123
155Stillbirth (HP:0003826)1.84839110
156Decreased central vision (HP:0007663)1.84552660
157Keratitis (HP:0000491)1.84491453
158Abnormal social behavior (HP:0012433)1.84399350
159Impaired social interactions (HP:0000735)1.84399350
160Specific learning disability (HP:0001328)1.83939057
161Protruding tongue (HP:0010808)1.83859081
162Polyphagia (HP:0002591)1.83522122
163Anxiety (HP:0000739)1.82957174
164Gait imbalance (HP:0002141)1.82948976
165Increased muscle lipid content (HP:0009058)1.81245935
166Combined immunodeficiency (HP:0005387)1.80873869
167Progressive macrocephaly (HP:0004481)1.80834553
168Acute encephalopathy (HP:0006846)1.80780031
169Mutism (HP:0002300)1.80323142
170Gastrointestinal stroma tumor (HP:0100723)1.80208811
171Agitation (HP:0000713)1.80139716
172Nonprogressive disorder (HP:0003680)1.79972112
173Synostosis involving bones of the hand (HP:0004278)1.79490740
174Recurrent bronchitis (HP:0002837)1.78753363
175Congenital sensorineural hearing impairment (HP:0008527)1.77451682
176Abnormality of the 1st metacarpal (HP:0010009)1.76694659
177Cerebral ischemia (HP:0002637)1.76565191
178Abnormal biliary tract physiology (HP:0012439)1.76366934
179Bile duct proliferation (HP:0001408)1.76366934
1802-3 toe syndactyly (HP:0004691)1.76096293
181Exercise intolerance (HP:0003546)1.75622740
182Nervous tissue neoplasm (HP:0030060)1.74997016
183Neuroectodermal neoplasm (HP:0030061)1.74997016
184Neuroepithelial neoplasm (HP:0030063)1.74997016
185Abnormality of the middle phalanges of the toes (HP:0010183)1.74922767
186Bony spicule pigmentary retinopathy (HP:0007737)1.73354756
187Portal hypertension (HP:0001409)1.72913378
188Abnormal mitochondria in muscle tissue (HP:0008316)1.71752884
189IgA deficiency (HP:0002720)1.71215451
190Abnormality of incisor morphology (HP:0011063)1.70471403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.68472649
2BRD45.76948845
3MAP3K125.40580022
4TRIM283.54250574
5CASK2.96737444
6CDK192.92018707
7TNIK2.78869140
8SRPK12.64978267
9EIF2AK32.63519565
10MAP2K72.45928313
11TSSK62.25061381
12PAK62.19004878
13PIK3CG2.09845688
14KSR22.02653144
15STK242.01510228
16PBK10.4219854
17AKT31.88279691
18STK41.82654989
19NTRK31.82436107
20SIK31.81611869
21KSR11.63121938
22MAP2K61.59424392
23MAP4K11.56838191
24NLK1.49255393
25WNK41.48198010
26ZAP701.47870556
27MARK11.44825832
28MAP2K41.41150769
29MINK11.41038454
30STK391.40769069
31MYLK1.34125077
32MAP3K41.33999288
33DAPK11.31568926
34CAMKK21.28779679
35STK161.25852978
36MUSK1.24481345
37RAF11.23145792
38MST41.14685333
39MAP3K61.12614026
40SYK1.12297414
41BMPR21.10943992
42TEC1.08247375
43PRPF4B1.05367223
44TAOK31.02387070
45BMPR1B0.96015031
46FES0.95563005
47SGK20.93134323
48MKNK20.90789349
49MAPK130.89946365
50PRKCH0.89137729
51MAPKAPK30.87002216
52STK38L0.84496496
53LCK0.83434265
54BCKDK0.82651767
55TLK10.82382232
56TNK20.81811106
57PAK30.81739215
58MAP3K90.81361898
59WNK10.81075227
60CSNK1G30.80894347
61PINK10.79844221
62CDK50.79206715
63MKNK10.78816391
64EIF2AK20.76915023
65NTRK20.69260956
66CSNK1G20.65979964
67GRK70.65887281
68SGK30.65838965
69ADRBK20.65534739
70SIK20.65446653
71SGK2230.65184841
72SGK4940.65184841
73IKBKB0.64662670
74IRAK10.64055186
75MAPKAPK50.63451928
76ACVR1B0.63362613
77GRK50.62787574
78NEK60.62536776
79VRK20.61208383
80PRKCG0.59880940
81TGFBR10.58603846
82PIM10.57000321
83MOS0.55796981
84CAMK2A0.55191656
85CAMKK10.55172971
86TYK20.54587781
87ITK0.53550201
88PHKG10.53113617
89PHKG20.53113617
90IKBKE0.52916582
91JAK30.52554051
92MARK30.51884446
93JAK20.51878156
94CAMK2B0.51485269
95STK30.51093798
96EPHA40.50441033
97MAP3K110.49250468
98CAMK40.47891886
99CSNK1G10.47840946
100RPS6KA10.47469282
101TBK10.46880383
102DAPK30.46874177
103BTK0.46375023
104GSK3A0.45961949
105OXSR10.45287966
106CSNK1A1L0.45029827
107PLK20.43788585
108BRAF0.43631456
109MATK0.43328191
110CDK180.43024653
111CDK90.42546009
112CHUK0.42496704
113PRKCE0.41885776
114HCK0.41561031
115MAP3K140.40107849
116FYN0.39729695
117MAP3K130.39167974
118DAPK20.38794280
119RET0.38582013
120ARAF0.36713244
121CAMK10.35778706
122CDK150.35745122
123JAK10.35431211
124PRKAA20.35231732
125CDK11A0.34825611
126ADRBK10.34716927
127CDK80.33974118
128PDK10.33778918
129ROCK10.33746809
130EIF2AK10.33405884
131ROCK20.33319843
132NME10.33261547
133IRAK40.32722203
134CDK140.32282740
135MET0.31865141
136PRKG20.31690611
137KIT0.31532217
138RPS6KA50.31275930
139PRKCQ0.30064790
140LYN0.29988620
141CDK40.29358407
142CAMK2G0.28920970
143TYRO30.26812785
144CLK10.25151664
145PRKCI0.24857844
146VRK10.23169511
147PRKG10.21145999
148RPS6KB10.20710078
149CSNK1A10.19418767
150GRK60.15577975
151CAMK2D0.15357983
152CSK0.15341670
153MAP3K50.15146806
154SGK10.14613780
155PAK10.13884932
156CSF1R0.13264350
157TAOK10.11816219
158GRK10.10648554
159IRAK30.09741518
160CSNK2A20.08568267
161PRKCZ0.07721654
162PRKCB0.07645659
163FRK0.07175055
164IGF1R0.06999145

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053104.48644595
2* Autoimmune thyroid disease_Homo sapiens_hsa053204.27126047
3* Allograft rejection_Homo sapiens_hsa053303.02338754
4* Intestinal immune network for IgA production_Homo sapiens_hsa046722.69142722
5Synaptic vesicle cycle_Homo sapiens_hsa047212.66109366
6Nicotine addiction_Homo sapiens_hsa050332.43431988
7* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29176374
8Primary immunodeficiency_Homo sapiens_hsa053402.26110321
9Protein export_Homo sapiens_hsa030602.24452835
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20119413
11* T cell receptor signaling pathway_Homo sapiens_hsa046602.09700302
12Proteasome_Homo sapiens_hsa030501.92203102
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88742804
14Caffeine metabolism_Homo sapiens_hsa002321.88038974
15Olfactory transduction_Homo sapiens_hsa047401.85244197
16Collecting duct acid secretion_Homo sapiens_hsa049661.75258425
17Rheumatoid arthritis_Homo sapiens_hsa053231.74533278
18Morphine addiction_Homo sapiens_hsa050321.74318765
19Circadian entrainment_Homo sapiens_hsa047131.71408712
20Serotonergic synapse_Homo sapiens_hsa047261.67722586
21GABAergic synapse_Homo sapiens_hsa047271.67416758
22Long-term potentiation_Homo sapiens_hsa047201.61429733
23Dopaminergic synapse_Homo sapiens_hsa047281.54714972
24Mismatch repair_Homo sapiens_hsa034301.49813606
25Glutamatergic synapse_Homo sapiens_hsa047241.48991294
26RNA transport_Homo sapiens_hsa030131.46735243
27African trypanosomiasis_Homo sapiens_hsa051431.41565089
28Parkinsons disease_Homo sapiens_hsa050121.39734944
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.39608804
30Amphetamine addiction_Homo sapiens_hsa050311.39553633
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35403867
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33506254
33Long-term depression_Homo sapiens_hsa047301.26429790
34Oxidative phosphorylation_Homo sapiens_hsa001901.26305594
35Basal transcription factors_Homo sapiens_hsa030221.26002138
36Histidine metabolism_Homo sapiens_hsa003401.25685570
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21927162
38* Leishmaniasis_Homo sapiens_hsa051401.21854087
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21533199
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21396449
41Taste transduction_Homo sapiens_hsa047421.17876344
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17659006
43Vibrio cholerae infection_Homo sapiens_hsa051101.17632595
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15927433
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15670727
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15171693
47Cocaine addiction_Homo sapiens_hsa050301.11053346
48Vitamin B6 metabolism_Homo sapiens_hsa007501.10944422
49Cholinergic synapse_Homo sapiens_hsa047251.10357555
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06295748
51* Hematopoietic cell lineage_Homo sapiens_hsa046401.05861939
52Salivary secretion_Homo sapiens_hsa049701.00613428
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99173516
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98527730
55* Jak-STAT signaling pathway_Homo sapiens_hsa046300.98129416
56Alzheimers disease_Homo sapiens_hsa050100.95140911
57Calcium signaling pathway_Homo sapiens_hsa040200.90581509
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89175683
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88888211
60* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88439123
61Malaria_Homo sapiens_hsa051440.88355669
62Graft-versus-host disease_Homo sapiens_hsa053320.87400166
63Spliceosome_Homo sapiens_hsa030400.87279525
64Renin-angiotensin system_Homo sapiens_hsa046140.86109214
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84489203
66Platelet activation_Homo sapiens_hsa046110.84337147
67Oxytocin signaling pathway_Homo sapiens_hsa049210.82774786
68* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81298732
69RNA degradation_Homo sapiens_hsa030180.80926499
70Type I diabetes mellitus_Homo sapiens_hsa049400.78424558
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78237325
72Ovarian steroidogenesis_Homo sapiens_hsa049130.78018357
73Chemokine signaling pathway_Homo sapiens_hsa040620.77349813
74Fanconi anemia pathway_Homo sapiens_hsa034600.76116261
75Renin secretion_Homo sapiens_hsa049240.74444133
76Nucleotide excision repair_Homo sapiens_hsa034200.73818392
77* Measles_Homo sapiens_hsa051620.73743574
78Pertussis_Homo sapiens_hsa051330.73390406
79Gastric acid secretion_Homo sapiens_hsa049710.71104820
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.70907509
81cAMP signaling pathway_Homo sapiens_hsa040240.69035105
82MAPK signaling pathway_Homo sapiens_hsa040100.67682741
83Viral carcinogenesis_Homo sapiens_hsa052030.67529368
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67438860
85TNF signaling pathway_Homo sapiens_hsa046680.66559195
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65988012
87Tuberculosis_Homo sapiens_hsa051520.64946228
88Ribosome_Homo sapiens_hsa030100.64299450
89Huntingtons disease_Homo sapiens_hsa050160.62897293
90Phagosome_Homo sapiens_hsa041450.61869887
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61540409
92Peroxisome_Homo sapiens_hsa041460.59903547
93Insulin secretion_Homo sapiens_hsa049110.59801886
94Insulin signaling pathway_Homo sapiens_hsa049100.59216361
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59102764
96Prolactin signaling pathway_Homo sapiens_hsa049170.58945750
97Mineral absorption_Homo sapiens_hsa049780.58742877
98ErbB signaling pathway_Homo sapiens_hsa040120.58684215
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.56297544
100Circadian rhythm_Homo sapiens_hsa047100.56162341
101Sphingolipid metabolism_Homo sapiens_hsa006000.55983340
102Gap junction_Homo sapiens_hsa045400.55040265
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54092494
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53938665
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53933548
106Herpes simplex infection_Homo sapiens_hsa051680.52920102
107Toxoplasmosis_Homo sapiens_hsa051450.52869048
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51981097
109Salmonella infection_Homo sapiens_hsa051320.50766308
110Osteoclast differentiation_Homo sapiens_hsa043800.48223897
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48019454
112Shigellosis_Homo sapiens_hsa051310.47823173
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46213503
114B cell receptor signaling pathway_Homo sapiens_hsa046620.46110408
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.46096611
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46094126
117RNA polymerase_Homo sapiens_hsa030200.44401418
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43787100
119Arginine and proline metabolism_Homo sapiens_hsa003300.43660765
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41173975
121Axon guidance_Homo sapiens_hsa043600.40873570
122Pyrimidine metabolism_Homo sapiens_hsa002400.40726444
123Homologous recombination_Homo sapiens_hsa034400.40655160
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40416061
125Phototransduction_Homo sapiens_hsa047440.40256566
126Rap1 signaling pathway_Homo sapiens_hsa040150.40098841
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40088196
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39936848
129Legionellosis_Homo sapiens_hsa051340.38067185
130GnRH signaling pathway_Homo sapiens_hsa049120.36868696
131Alcoholism_Homo sapiens_hsa050340.36536963
132Cell cycle_Homo sapiens_hsa041100.35974466
133Ras signaling pathway_Homo sapiens_hsa040140.35707181
134mRNA surveillance pathway_Homo sapiens_hsa030150.35503184
135VEGF signaling pathway_Homo sapiens_hsa043700.34759862
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.34453170
137Apoptosis_Homo sapiens_hsa042100.34383026
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33908631
139Purine metabolism_Homo sapiens_hsa002300.33077596
140Cardiac muscle contraction_Homo sapiens_hsa042600.32635377
141Regulation of autophagy_Homo sapiens_hsa041400.32542231
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31588255
143Thyroid hormone synthesis_Homo sapiens_hsa049180.31397350
144p53 signaling pathway_Homo sapiens_hsa041150.30021915
145HTLV-I infection_Homo sapiens_hsa051660.26226203
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.25983484
147Antigen processing and presentation_Homo sapiens_hsa046120.24475521
148Dorso-ventral axis formation_Homo sapiens_hsa043200.23926921
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23773842
150TGF-beta signaling pathway_Homo sapiens_hsa043500.22622078
151Arachidonic acid metabolism_Homo sapiens_hsa005900.22597503
152Steroid biosynthesis_Homo sapiens_hsa001000.20049351
153Hepatitis B_Homo sapiens_hsa051610.19864007
154Influenza A_Homo sapiens_hsa051640.19272103
155Vitamin digestion and absorption_Homo sapiens_hsa049770.18954064
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17544155
157Oocyte meiosis_Homo sapiens_hsa041140.17406893
158Viral myocarditis_Homo sapiens_hsa054160.17277893
159Acute myeloid leukemia_Homo sapiens_hsa052210.16439341
160Epstein-Barr virus infection_Homo sapiens_hsa051690.12623374
161Linoleic acid metabolism_Homo sapiens_hsa005910.09851235
162FoxO signaling pathway_Homo sapiens_hsa040680.09483269
163Toll-like receptor signaling pathway_Homo sapiens_hsa046200.07554113
164Insulin resistance_Homo sapiens_hsa049310.06667522
165Nitrogen metabolism_Homo sapiens_hsa009100.05385653

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