IL4R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.53422598
2negative regulation of cell killing (GO:0031342)5.30602841
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30602841
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.06429726
5antigen processing and presentation of endogenous antigen (GO:0019883)4.90388092
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83122604
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.73175205
8positive regulation by symbiont of host defense response (GO:0052509)4.48252427
9modulation by symbiont of host defense response (GO:0052031)4.48252427
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48252427
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48252427
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.48252427
13modulation by symbiont of host immune response (GO:0052553)4.48252427
14regulation of B cell receptor signaling pathway (GO:0050855)4.28463553
15macrophage activation involved in immune response (GO:0002281)4.26361083
16detection of other organism (GO:0098543)4.23216505
17regulation of gamma-delta T cell activation (GO:0046643)4.17670804
18detection of bacterium (GO:0016045)4.16484342
19leukocyte aggregation (GO:0070486)4.01299596
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96750595
21negative regulation of interleukin-12 production (GO:0032695)3.89886153
22B cell receptor signaling pathway (GO:0050853)3.88622344
23immunoglobulin mediated immune response (GO:0016064)3.85693089
24response to peptidoglycan (GO:0032494)3.80951675
25germinal center formation (GO:0002467)3.79096636
26neutrophil activation involved in immune response (GO:0002283)3.76824982
27regulation of gamma-delta T cell differentiation (GO:0045586)3.71581048
28regulation of interferon-beta biosynthetic process (GO:0045357)3.70530998
29NIK/NF-kappaB signaling (GO:0038061)3.63495047
30positive thymic T cell selection (GO:0045059)3.56120444
31cellular response to type I interferon (GO:0071357)3.55899494
32type I interferon signaling pathway (GO:0060337)3.55899494
33detection of external biotic stimulus (GO:0098581)3.55844498
34response to type I interferon (GO:0034340)3.54713124
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47118031
36response to muramyl dipeptide (GO:0032495)3.42029972
37cellular extravasation (GO:0045123)3.41601078
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.36831891
39response to interleukin-15 (GO:0070672)3.36644719
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35997517
41regulation of antigen processing and presentation (GO:0002577)3.33468112
42negative thymic T cell selection (GO:0045060)3.30719300
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28911558
44interferon-gamma-mediated signaling pathway (GO:0060333)3.28100381
45regulation of T cell tolerance induction (GO:0002664)3.26176948
46detection of molecule of bacterial origin (GO:0032490)3.23948366
47tolerance induction (GO:0002507)3.20730700
48thymic T cell selection (GO:0045061)3.19837244
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17745013
50negative T cell selection (GO:0043383)3.17344469
51negative regulation of erythrocyte differentiation (GO:0045647)3.16404240
52negative regulation of T cell mediated immunity (GO:0002710)3.15012610
53positive regulation of B cell differentiation (GO:0045579)3.13150971
54* defense response to protozoan (GO:0042832)3.13145700
55regulation of B cell differentiation (GO:0045577)3.13010552
56T cell selection (GO:0045058)3.12872760
57negative regulation of leukocyte mediated immunity (GO:0002704)3.11515734
58detection of biotic stimulus (GO:0009595)3.11104872
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09301991
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05533469
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03327851
62regulation of tolerance induction (GO:0002643)3.00150284
63cellular response to interleukin-15 (GO:0071350)2.97058089
64response to host immune response (GO:0052572)2.95199350
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95199350
66positive T cell selection (GO:0043368)2.94066451
67myeloid cell activation involved in immune response (GO:0002275)2.93984901
68B cell mediated immunity (GO:0019724)2.93273588
69neutrophil activation (GO:0042119)2.92021920
70* response to protozoan (GO:0001562)2.90679523
71antigen processing and presentation via MHC class Ib (GO:0002475)2.88286704
72T cell migration (GO:0072678)2.87806885
73regulation of mast cell degranulation (GO:0043304)2.87794771
74myeloid dendritic cell differentiation (GO:0043011)2.87585332
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85999037
76response to host (GO:0075136)2.85999037
77response to host defenses (GO:0052200)2.85999037
78granulocyte activation (GO:0036230)2.85530451
79respiratory burst (GO:0045730)2.85155413
80negative regulation of cytokine production involved in immune response (GO:0002719)2.84280075
81macrophage activation (GO:0042116)2.84041586
82positive regulation of antigen processing and presentation (GO:0002579)2.81604517
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79037911
84negative regulation of innate immune response (GO:0045824)2.74323052
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73340655
86positive regulation of interferon-alpha production (GO:0032727)2.72232212
87myeloid dendritic cell activation (GO:0001773)2.71978625
88regulation of interferon-alpha production (GO:0032647)2.69491945
89regulation of leukocyte degranulation (GO:0043300)2.69157532
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68829600
91regulation of natural killer cell mediated immunity (GO:0002715)2.68829600
92positive regulation of tolerance induction (GO:0002645)2.68275862
93negative regulation of interleukin-6 production (GO:0032715)2.66130185
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.65212749
95regulation of alpha-beta T cell proliferation (GO:0046640)2.64830273
96T-helper 1 type immune response (GO:0042088)2.63341307
97B cell homeostasis (GO:0001782)2.62000155
98regulation of T cell mediated cytotoxicity (GO:0001914)2.60098265
99regulation of mast cell activation involved in immune response (GO:0033006)2.59227234
100negative regulation of type 2 immune response (GO:0002829)2.58890075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.03372138
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73165458
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.71446494
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.60831563
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.20328720
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96270151
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89550719
8MYC_22102868_ChIP-Seq_BL_Human2.78002698
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.72311976
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64533520
11VDR_21846776_ChIP-Seq_THP-1_Human2.64191033
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62583161
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54650189
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.45023212
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42048629
16RUNX_20019798_ChIP-Seq_JUKART_Human2.39868516
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39565004
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35555550
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.34073374
20VDR_24763502_ChIP-Seq_THP-1_Human2.33343268
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33319020
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31856432
23* MAF_26560356_Chip-Seq_TH1_Human2.25797117
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.21764420
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16322903
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15706456
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13950499
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.10969556
29TCF7_22412390_ChIP-Seq_EML_Mouse2.09937283
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05294816
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02039628
32* MYB_26560356_Chip-Seq_TH2_Human2.01555809
33SPI1_23127762_ChIP-Seq_K562_Human2.00237018
34SPI1_23547873_ChIP-Seq_NB4_Human1.97187037
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.96790710
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95675203
37UTX_26944678_Chip-Seq_JUKART_Human1.94505604
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.94472537
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92173030
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91030225
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89496327
42KDM2B_26808549_Chip-Seq_DND41_Human1.88576519
43MYB_26560356_Chip-Seq_TH1_Human1.86038732
44SCL_19346495_ChIP-Seq_HPC-7_Human1.77937537
45MAF_26560356_Chip-Seq_TH2_Human1.69917027
46LXR_22292898_ChIP-Seq_THP-1_Human1.69774223
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69305345
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68873075
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52589774
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.51181299
51VDR_24787735_ChIP-Seq_THP-1_Human1.50323307
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39523706
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.39413917
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37356688
55GATA3_27048872_Chip-Seq_THYMUS_Human1.29807503
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.29675767
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29112948
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28103018
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.27670386
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24700136
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24675210
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23890986
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20502034
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20465280
65RACK7_27058665_Chip-Seq_MCF-7_Human1.20234297
66PU_27001747_Chip-Seq_BMDM_Mouse1.19312877
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19104578
68GATA1_22025678_ChIP-Seq_K562_Human1.19078016
69GATA1_19941826_ChIP-Seq_K562_Human1.16350311
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15922859
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15774958
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14239345
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14140657
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12646092
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05340182
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05145959
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05037332
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04770846
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03450782
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03018399
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02074391
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01139364
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00950969
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.00376178
85* BCOR_27268052_Chip-Seq_Bcells_Human1.00042936
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99813670
87KDM2B_26808549_Chip-Seq_K562_Human0.98027205
88NCOR1_26117541_ChIP-Seq_K562_Human0.97108832
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95507338
90* BCL6_27268052_Chip-Seq_Bcells_Human0.95474675
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94989509
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93874220
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91972441
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91848857
95GATA3_26560356_Chip-Seq_TH2_Human0.91504787
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89215357
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88383045
98* SA1_27219007_Chip-Seq_ERYTHROID_Human0.87904022
99* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85964727
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84393109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.00280479
2MP0003436_decreased_susceptibility_to3.80626065
3MP0003724_increased_susceptibility_to3.63084031
4MP0001835_abnormal_antigen_presentation3.48577196
5MP0001790_abnormal_immune_system3.13469583
6MP0005387_immune_system_phenotype3.13469583
7MP0001800_abnormal_humoral_immune2.92565399
8MP0003300_gastrointestinal_ulcer2.81394230
9MP0005000_abnormal_immune_tolerance2.80290756
10MP0000685_abnormal_immune_system2.79728059
11MP0005671_abnormal_response_to2.76045050
12MP0009785_altered_susceptibility_to2.69962348
13MP0002419_abnormal_innate_immunity2.63597631
14MP0003763_abnormal_thymus_physiology2.62553743
15MP0005025_abnormal_response_to2.60367129
16MP0002452_abnormal_antigen_presenting2.49979813
17MP0002723_abnormal_immune_serum2.48108645
18MP0002420_abnormal_adaptive_immunity2.33844339
19MP0002148_abnormal_hypersensitivity_rea2.31288437
20MP0001819_abnormal_immune_cell2.31204750
21MP0006082_CNS_inflammation2.30720677
22MP0004947_skin_inflammation2.14102683
23MP0010155_abnormal_intestine_physiology2.02853626
24MP0004510_myositis2.01875565
25MP0003191_abnormal_cellular_cholesterol1.99941564
26MP0002405_respiratory_system_inflammati1.99456043
27MP0001533_abnormal_skeleton_physiology1.99265599
28MP0005451_abnormal_body_composition1.86973634
29MP0002138_abnormal_hepatobiliary_system1.82060709
30MP0009333_abnormal_splenocyte_physiolog1.80819741
31MP0000716_abnormal_immune_system1.80740573
32MP0002398_abnormal_bone_marrow1.80376625
33MP0001873_stomach_inflammation1.72959977
34MP0001845_abnormal_inflammatory_respons1.71914182
35MP0003172_abnormal_lysosome_physiology1.71084124
36MP0005464_abnormal_platelet_physiology1.67381760
37MP0008260_abnormal_autophagy1.63390526
38MP0005058_abnormal_lysosome_morphology1.60820855
39MP0005310_abnormal_salivary_gland1.53409985
40MP0009840_abnormal_foam_cell1.53085332
41MP0000465_gastrointestinal_hemorrhage1.52323304
42MP0000689_abnormal_spleen_morphology1.49396636
43MP0009278_abnormal_bone_marrow1.45902645
44MP0000858_altered_metastatic_potential1.45645933
45MP0002722_abnormal_immune_system1.44846746
46MP0002429_abnormal_blood_cell1.41996258
47MP0008469_abnormal_protein_level1.38845852
48MP0002998_abnormal_bone_remodeling1.38757276
49MP0003866_abnormal_defecation1.36841058
50MP0001853_heart_inflammation1.35295866
51MP0003828_pulmonary_edema1.31907657
52MP0009764_decreased_sensitivity_to1.31886007
53MP0003091_abnormal_cell_migration1.29153214
54MP0002933_joint_inflammation1.27854715
55MP0001851_eye_inflammation1.27300740
56MP0003183_abnormal_peptide_metabolism1.25643461
57MP0008004_abnormal_stomach_pH1.24978746
58MP0000703_abnormal_thymus_morphology1.24923977
59MP0003453_abnormal_keratinocyte_physiol1.21863220
60MP0004381_abnormal_hair_follicle1.21654452
61MP0003075_altered_response_to1.17675214
62MP0005166_decreased_susceptibility_to1.14624004
63MP0003566_abnormal_cell_adhesion1.12236868
64MP0002396_abnormal_hematopoietic_system1.11728363
65MP0002254_reproductive_system_inflammat1.11630110
66MP0003448_altered_tumor_morphology1.10182819
67MP0004883_abnormal_blood_vessel1.09335312
68MP0001545_abnormal_hematopoietic_system1.07613451
69MP0005397_hematopoietic_system_phenotyp1.07613451
70MP0003705_abnormal_hypodermis_morpholog1.05053009
71MP0005164_abnormal_response_to1.02093909
72MP0002132_abnormal_respiratory_system1.00685589
73MP0001663_abnormal_digestive_system0.98069131
74MP0000604_amyloidosis0.96971031
75MP0002166_altered_tumor_susceptibility0.94497469
76MP0000343_altered_response_to0.93751234
77MP0005390_skeleton_phenotype0.90104580
78MP0005023_abnormal_wound_healing0.90001461
79MP0003279_aneurysm0.87743216
80MP0003045_fibrosis0.87723824
81MP0000249_abnormal_blood_vessel0.87723561
82MP0005076_abnormal_cell_differentiation0.85444158
83MP0000490_abnormal_crypts_of0.82342597
84MP0004808_abnormal_hematopoietic_stem0.80745361
85MP0009763_increased_sensitivity_to0.77763591
86MP0002139_abnormal_hepatobiliary_system0.74886000
87MP0003690_abnormal_glial_cell0.73369045
88MP0003656_abnormal_erythrocyte_physiolo0.71165086
89MP0003795_abnormal_bone_structure0.67879142
90MP0000767_abnormal_smooth_muscle0.67392164
91MP0001849_ear_inflammation0.67286558
92MP0001958_emphysema0.66432452
93MP0002006_tumorigenesis0.65381641
94MP0008874_decreased_physiological_sensi0.64940997
95MP0005381_digestive/alimentary_phenotyp0.63361229
96MP0002277_abnormal_respiratory_mucosa0.60053060
97MP0002332_abnormal_exercise_endurance0.56298218
98MP0002796_impaired_skin_barrier0.55075446
99MP0009765_abnormal_xenobiotic_induced0.54862927
100MP0000609_abnormal_liver_physiology0.53635901

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.60036619
2Recurrent bacterial skin infections (HP:0005406)4.72395148
3Recurrent abscess formation (HP:0002722)4.58047830
4Abnormality of macrophages (HP:0004311)4.48869979
5Myositis (HP:0100614)4.45863078
6Orchitis (HP:0100796)4.26176014
7Optic neuritis (HP:0100653)4.01585503
8Retrobulbar optic neuritis (HP:0100654)4.01585503
9Mediastinal lymphadenopathy (HP:0100721)3.92940051
10Recurrent gram-negative bacterial infections (HP:0005420)3.78844007
11Meningitis (HP:0001287)3.74414698
12Stomatitis (HP:0010280)3.57968808
13Recurrent fungal infections (HP:0002841)3.53039839
14Vasculitis (HP:0002633)3.47580479
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.45089038
16Cellulitis (HP:0100658)3.44938063
17Increased IgE level (HP:0003212)3.41355442
18Elevated erythrocyte sedimentation rate (HP:0003565)3.35176727
19Gastrointestinal infarctions (HP:0005244)3.32930032
20Colitis (HP:0002583)3.28013311
21Spontaneous hematomas (HP:0007420)3.27494299
22Agammaglobulinemia (HP:0004432)3.26187350
23Gastrointestinal stroma tumor (HP:0100723)3.25756711
24Recurrent viral infections (HP:0004429)3.20076208
25Recurrent skin infections (HP:0001581)3.19725426
26Chronic obstructive pulmonary disease (HP:0006510)3.19080969
27Obstructive lung disease (HP:0006536)3.19080969
28Inflammation of the large intestine (HP:0002037)3.09201963
29Pustule (HP:0200039)3.08167787
30Gastrointestinal inflammation (HP:0004386)3.06887699
31Keratoconjunctivitis sicca (HP:0001097)3.02387931
32Gingivitis (HP:0000230)3.00783883
33Pulmonary infiltrates (HP:0002113)2.98094362
34Recurrent cutaneous fungal infections (HP:0011370)2.95723057
35Chronic mucocutaneous candidiasis (HP:0002728)2.95723057
36Encephalitis (HP:0002383)2.89322973
37T lymphocytopenia (HP:0005403)2.87398265
38Systemic lupus erythematosus (HP:0002725)2.81296997
39Keratoconjunctivitis (HP:0001096)2.74132644
40Hemoptysis (HP:0002105)2.70369452
41Abnormality of T cell number (HP:0011839)2.68503077
42Panhypogammaglobulinemia (HP:0003139)2.67188100
43Lymphopenia (HP:0001888)2.62795832
44Urticaria (HP:0001025)2.60686190
45Osteomyelitis (HP:0002754)2.59303837
46Prolonged bleeding time (HP:0003010)2.56857762
47Recurrent bronchitis (HP:0002837)2.56717543
48Papilloma (HP:0012740)2.53035757
49Verrucae (HP:0200043)2.53035757
50Epistaxis (HP:0000421)2.49543242
51Emphysema (HP:0002097)2.48763568
52Abnormality of glycolipid metabolism (HP:0010969)2.48489802
53Abnormality of liposaccharide metabolism (HP:0010968)2.48489802
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.48489802
55Chest pain (HP:0100749)2.48414702
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.46687159
57Restrictive lung disease (HP:0002091)2.36122519
58Pulmonary embolism (HP:0002204)2.35337821
59Recurrent sinusitis (HP:0011108)2.35225164
60Malnutrition (HP:0004395)2.31245287
61Interstitial pulmonary disease (HP:0006530)2.28482878
62Gangrene (HP:0100758)2.27973181
63Gingival bleeding (HP:0000225)2.27523946
64Abnormality of T cells (HP:0002843)2.27212989
65Increased IgM level (HP:0003496)2.25269314
66Dysostosis multiplex (HP:0000943)2.24234664
67Arterial thrombosis (HP:0004420)2.22796993
68Sepsis (HP:0100806)2.22230052
69Hematochezia (HP:0002573)2.21696295
70Loss of speech (HP:0002371)2.20513486
71Skin ulcer (HP:0200042)2.16980166
72Leukocytosis (HP:0001974)2.16574806
73Premature loss of primary teeth (HP:0006323)2.16544700
74Hypergammaglobulinemia (HP:0010702)2.12757154
75Abnormality of the pleura (HP:0002103)2.10493569
76Abnormality of the peritoneum (HP:0002585)2.09985216
77Peritonitis (HP:0002586)2.09610060
78Increased cerebral lipofuscin (HP:0011813)2.08817779
79Viral hepatitis (HP:0006562)2.08338617
80Purpura (HP:0000979)2.04594418
81Abnormality of the nasal mucosa (HP:0000433)2.04357735
82Granulocytopenia (HP:0001913)2.03892777
83Anorexia (HP:0002039)2.01561936
84IgM deficiency (HP:0002850)2.01301296
85Amyloidosis (HP:0011034)1.96803260
86Autoimmune hemolytic anemia (HP:0001890)1.94189206
87Recurrent pneumonia (HP:0006532)1.94052632
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93137809
89Glomerulonephritis (HP:0000099)1.92033403
90Increased serum ferritin (HP:0003281)1.91978930
91Chronic otitis media (HP:0000389)1.91975764
92Recurrent lower respiratory tract infections (HP:0002783)1.89793678
93Arthralgia (HP:0002829)1.89550184
94Nasal polyposis (HP:0100582)1.89494742
95Glomerulopathy (HP:0100820)1.89373936
96Chronic diarrhea (HP:0002028)1.88983631
97Abnormality of T cell physiology (HP:0011840)1.88760842
98Segmental peripheral demyelination/remyelination (HP:0003481)1.88590696
99Autoimmune thrombocytopenia (HP:0001973)1.88362535
100Episodic fever (HP:0001954)1.87404382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.31011240
2RIPK43.58581255
3ERN13.48028589
4PRPF4B2.94835643
5BLK2.76152525
6TYK22.63629229
7MAP3K142.37592204
8IRAK42.34815123
9CSK2.18715996
10MAP2K32.03789226
11MAP3K131.94673977
12ZAP701.91559955
13TXK1.91269894
14JAK31.85820817
15TRIB31.79532483
16FES1.76498692
17BTK1.74068672
18TBK11.71329523
19IKBKE1.70881996
20GRK61.65238747
21MAP3K31.65201064
22EPHB11.63319875
23IRAK31.60592895
24SIK31.60160219
25JAK11.52358677
26SYK1.50526453
27TAOK11.50007518
28SIK11.47948540
29MAP3K101.40529933
30CDC42BPA1.39754428
31TNK21.37387746
32CSF1R1.36827279
33FGFR41.36798017
34FGR1.35298799
35HCK1.34830939
36RIPK11.31719990
37TGFBR21.31467986
38MAP3K111.28518745
39IKBKB1.28183381
40SMG11.26588529
41MAP3K11.22625990
42TAOK21.18703876
43LYN1.15161657
44LCK1.07400425
45MARK21.06008148
46ITK1.03536738
47JAK20.99658697
48SIK20.99376350
49KIT0.99312424
50NME20.99015047
51STK100.96839960
52MATK0.95494724
53BMPR20.90209808
54PRKD20.88386788
55IRAK10.86718181
56FGFR30.86027614
57MARK30.85844738
58KSR20.78554728
59TEC0.78429779
60HIPK20.77522856
61TESK20.77473053
62PTK60.74971084
63CDK120.74496275
64MAP3K70.73075498
65PDK10.72809437
66PDPK10.69720413
67MAPK70.69401946
68IRAK20.68833217
69NLK0.68221228
70CHUK0.66312485
71GRK70.65265956
72MAPK120.65240485
73TAOK30.64587108
74MAP3K60.62677024
75LRRK20.59702827
76ICK0.58572877
77EPHA30.56981704
78CDK40.55838605
79FYN0.52461824
80YES10.51152724
81PRKCQ0.50976584
82TTN0.50875879
83MAPK110.47707840
84RPS6KC10.47198568
85RPS6KL10.47198568
86MOS0.44773882
87MELK0.44502770
88RET0.43343473
89PIM10.43253908
90MAP3K20.40944464
91MAPKAPK20.39990871
92BMX0.38052286
93MAPK40.37285113
94PDGFRB0.36847676
95MAP3K50.36710014
96RPS6KA60.35207410
97MAP3K80.35066724
98MAP2K20.35019287
99CDK60.33980588
100SGK30.33607006

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.74463011
2Allograft rejection_Homo sapiens_hsa053302.69755385
3Staphylococcus aureus infection_Homo sapiens_hsa051502.67781475
4Osteoclast differentiation_Homo sapiens_hsa043802.60633215
5Graft-versus-host disease_Homo sapiens_hsa053322.55354341
6B cell receptor signaling pathway_Homo sapiens_hsa046622.49087152
7Autoimmune thyroid disease_Homo sapiens_hsa053202.47373801
8Primary immunodeficiency_Homo sapiens_hsa053402.31107960
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.12483032
10* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11134974
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.02340654
12Asthma_Homo sapiens_hsa053101.98069438
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94000877
14Type I diabetes mellitus_Homo sapiens_hsa049401.86912646
15Tuberculosis_Homo sapiens_hsa051521.86820023
16Other glycan degradation_Homo sapiens_hsa005111.80991619
17Toxoplasmosis_Homo sapiens_hsa051451.79828136
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73567616
19Antigen processing and presentation_Homo sapiens_hsa046121.72514019
20T cell receptor signaling pathway_Homo sapiens_hsa046601.66292800
21Viral myocarditis_Homo sapiens_hsa054161.64740125
22* Hematopoietic cell lineage_Homo sapiens_hsa046401.64524069
23Malaria_Homo sapiens_hsa051441.63115180
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62813252
25Acute myeloid leukemia_Homo sapiens_hsa052211.62786930
26Influenza A_Homo sapiens_hsa051641.60239953
27TNF signaling pathway_Homo sapiens_hsa046681.57943202
28Measles_Homo sapiens_hsa051621.56858493
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56395762
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49938598
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46534479
32Herpes simplex infection_Homo sapiens_hsa051681.41016278
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40552839
34Pertussis_Homo sapiens_hsa051331.32602671
35Chemokine signaling pathway_Homo sapiens_hsa040621.32165924
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29722055
37Rheumatoid arthritis_Homo sapiens_hsa053231.27116525
38* Jak-STAT signaling pathway_Homo sapiens_hsa046301.26952242
39Legionellosis_Homo sapiens_hsa051341.18641964
40Hepatitis B_Homo sapiens_hsa051611.17626540
41Hepatitis C_Homo sapiens_hsa051601.16927068
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.13326719
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11557542
44African trypanosomiasis_Homo sapiens_hsa051431.11303405
45Phagosome_Homo sapiens_hsa041451.06004055
46Chronic myeloid leukemia_Homo sapiens_hsa052201.04230769
47Non-small cell lung cancer_Homo sapiens_hsa052230.99865790
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98860505
49VEGF signaling pathway_Homo sapiens_hsa043700.98329940
50Apoptosis_Homo sapiens_hsa042100.95722409
51Pancreatic cancer_Homo sapiens_hsa052120.94728916
52Lysosome_Homo sapiens_hsa041420.94108731
53Shigellosis_Homo sapiens_hsa051310.92443920
54* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89591258
55Salmonella infection_Homo sapiens_hsa051320.88949671
56Notch signaling pathway_Homo sapiens_hsa043300.88820894
57Platelet activation_Homo sapiens_hsa046110.86336187
58Renal cell carcinoma_Homo sapiens_hsa052110.81842799
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81554506
60Prolactin signaling pathway_Homo sapiens_hsa049170.81224284
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.80473188
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80096112
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.79953484
64Amoebiasis_Homo sapiens_hsa051460.79250922
65Epstein-Barr virus infection_Homo sapiens_hsa051690.76888440
66HTLV-I infection_Homo sapiens_hsa051660.75061318
67Complement and coagulation cascades_Homo sapiens_hsa046100.69275706
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66473610
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.64884489
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.64605897
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.64065396
72Viral carcinogenesis_Homo sapiens_hsa052030.60893013
73Prion diseases_Homo sapiens_hsa050200.59379093
74FoxO signaling pathway_Homo sapiens_hsa040680.59317170
75Endocytosis_Homo sapiens_hsa041440.59307047
76Insulin resistance_Homo sapiens_hsa049310.58514673
77GnRH signaling pathway_Homo sapiens_hsa049120.56942216
78Choline metabolism in cancer_Homo sapiens_hsa052310.54890070
79Endometrial cancer_Homo sapiens_hsa052130.54774020
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54068927
81Dorso-ventral axis formation_Homo sapiens_hsa043200.51664179
82Bladder cancer_Homo sapiens_hsa052190.51396812
83Small cell lung cancer_Homo sapiens_hsa052220.50932690
84HIF-1 signaling pathway_Homo sapiens_hsa040660.50125361
85Prostate cancer_Homo sapiens_hsa052150.47571265
86mTOR signaling pathway_Homo sapiens_hsa041500.47228667
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46065424
88MAPK signaling pathway_Homo sapiens_hsa040100.44749873
89Colorectal cancer_Homo sapiens_hsa052100.44230656
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43297289
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39935734
92Inositol phosphate metabolism_Homo sapiens_hsa005620.38909486
93ErbB signaling pathway_Homo sapiens_hsa040120.37704717
94Proteoglycans in cancer_Homo sapiens_hsa052050.35524768
95Rap1 signaling pathway_Homo sapiens_hsa040150.34322507
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33946493
97Insulin signaling pathway_Homo sapiens_hsa049100.33303107
98Type II diabetes mellitus_Homo sapiens_hsa049300.32955074
99Focal adhesion_Homo sapiens_hsa045100.32730200
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31367918

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