IL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of tumor necrosis factor biosynthetic process (GO:0042534)9.60500581
2regulation of transforming growth factor beta production (GO:0071634)9.55415562
3signal peptide processing (GO:0006465)9.40887560
4negative regulation of alpha-beta T cell differentiation (GO:0046639)9.30187243
5regulation of MHC class II biosynthetic process (GO:0045346)9.11628516
6positive regulation of chemokine biosynthetic process (GO:0045080)9.09952931
7cytokine production involved in immune response (GO:0002367)9.02701358
8tolerance induction (GO:0002507)9.01344745
9inositol phosphate-mediated signaling (GO:0048016)8.93193950
10regulation of interleukin-13 production (GO:0032656)8.76438577
11response to mercury ion (GO:0046689)8.56546850
12positive regulation of isotype switching (GO:0045830)8.52625827
13tyrosine phosphorylation of STAT protein (GO:0007260)8.37260711
14serotonin metabolic process (GO:0042428)8.33565131
15regulation of macrophage activation (GO:0043030)8.20540648
16negative regulation of acute inflammatory response (GO:0002674)7.99213458
17T cell lineage commitment (GO:0002360)7.67926774
18positive regulation of DNA recombination (GO:0045911)7.49998222
19regulation of transforming growth factor beta1 production (GO:0032908)7.27274860
20positive regulation of chemokine secretion (GO:0090197)7.26560005
21primary amino compound metabolic process (GO:1901160)7.01267364
22regulation of chemokine biosynthetic process (GO:0045073)6.93006934
23* positive regulation of immunoglobulin production (GO:0002639)6.81572837
24positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)6.26296115
25CD4-positive, alpha-beta T cell differentiation (GO:0043367)6.26270716
26cytokine biosynthetic process (GO:0042089)6.21411733
27mammary gland alveolus development (GO:0060749)6.12306111
28positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.00537959
29regulation of isotype switching (GO:0045191)5.97377145
30CD4-positive, alpha-beta T cell activation (GO:0035710)5.93944308
31negative regulation of alpha-beta T cell activation (GO:0046636)5.79358965
32regulation of chemokine secretion (GO:0090196)5.74567812
33production of molecular mediator of immune response (GO:0002440)5.69100670
34* regulation of immunoglobulin production (GO:0002637)5.58300455
35indolalkylamine metabolic process (GO:0006586)5.55496576
36response to interleukin-15 (GO:0070672)5.53160551
37* positive regulation of B cell proliferation (GO:0030890)5.46692415
38regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.40069892
39protein carboxylation (GO:0018214)5.34902350
40peptidyl-glutamic acid carboxylation (GO:0017187)5.34902350
41T cell mediated immunity (GO:0002456)5.25934361
42cellular response to interleukin-15 (GO:0071350)5.24443415
43bone remodeling (GO:0046849)5.18956845
44viral protein processing (GO:0019082)5.04132385
45cytokine metabolic process (GO:0042107)5.02150466
46positive regulation of activated T cell proliferation (GO:0042104)5.02064586
47positive regulation of B cell mediated immunity (GO:0002714)5.01147936
48positive regulation of immunoglobulin mediated immune response (GO:0002891)5.01147936
49regulation of membrane protein ectodomain proteolysis (GO:0051043)4.95389655
50positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.91902554
51regulation of T-helper cell differentiation (GO:0045622)4.86093313
52kinetochore assembly (GO:0051382)4.82597189
53alpha-beta T cell differentiation (GO:0046632)4.59498656
54* regulation of B cell proliferation (GO:0030888)4.51080966
55negative regulation of T cell differentiation (GO:0045581)4.49922821
56innate immune response in mucosa (GO:0002227)4.47724777
57positive regulation of Rho protein signal transduction (GO:0035025)4.40115602
58positive regulation of interleukin-10 production (GO:0032733)4.34843429
59regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.24622492
60positive regulation of calcium ion transport into cytosol (GO:0010524)4.21059330
61positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)4.19116018
62amine biosynthetic process (GO:0009309)4.14735727
63cellular biogenic amine biosynthetic process (GO:0042401)4.14735727
64regulation of tyrosine phosphorylation of STAT protein (GO:0042509)4.09003162
65alpha-beta T cell activation (GO:0046631)4.05797134
66negative regulation of meiosis (GO:0045835)3.97356116
67mucosal immune response (GO:0002385)3.95803796
68CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.92070769
69positive regulation of macrophage differentiation (GO:0045651)3.91628191
70negative regulation of interleukin-12 production (GO:0032695)3.91132732
71JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.88622957
72kinetochore organization (GO:0051383)3.87373695
73T cell migration (GO:0072678)3.82175916
74negative regulation of epithelial cell differentiation (GO:0030857)3.81216326
75virion assembly (GO:0019068)3.79726997
76regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.73454675
77cellular response to mechanical stimulus (GO:0071260)3.72170107
78T cell activation involved in immune response (GO:0002286)3.69300580
79indole-containing compound metabolic process (GO:0042430)3.65444840
80* positive regulation of B cell activation (GO:0050871)3.64793496
81* positive regulation of production of molecular mediator of immune response (GO:0002702)3.64787191
82* positive regulation of JAK-STAT cascade (GO:0046427)3.61772042
83regulation of immunoglobulin mediated immune response (GO:0002889)3.61460565
84regulation of activated T cell proliferation (GO:0046006)3.60785672
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.57499178
86T-helper cell differentiation (GO:0042093)3.57499178
87organ or tissue specific immune response (GO:0002251)3.56656898
88aromatic amino acid family metabolic process (GO:0009072)3.51068942
89regulation of B cell mediated immunity (GO:0002712)3.49690916
90negative regulation of lymphocyte differentiation (GO:0045620)3.48932204
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47262824
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47262824
93positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.46043322
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44323645
95regulation of T-helper 1 type immune response (GO:0002825)3.38742491
96response to protozoan (GO:0001562)3.38208721
97dendritic cell differentiation (GO:0097028)3.36557229
98positive regulation of tolerance induction (GO:0002645)3.34910580
99regulation of RIG-I signaling pathway (GO:0039535)3.34577949
100activation of phospholipase C activity (GO:0007202)3.31711714
101leukocyte aggregation (GO:0070486)3.30750684
102defense response to protozoan (GO:0042832)3.28939463
103positive regulation of smooth muscle cell proliferation (GO:0048661)3.26028023
104response to nicotine (GO:0035094)3.23712309
105lung lobe morphogenesis (GO:0060463)3.22783470
106regulation of chronic inflammatory response (GO:0002676)3.19435598
107hepatocyte apoptotic process (GO:0097284)3.18407044
108* regulation of production of molecular mediator of immune response (GO:0002700)3.16070549
109negative thymic T cell selection (GO:0045060)3.13109193
110angiogenesis involved in wound healing (GO:0060055)3.10993227
111branching involved in labyrinthine layer morphogenesis (GO:0060670)3.08055897
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.07260092
113regulation of interleukin-10 production (GO:0032653)3.05546448
114negative regulation of cytokine production involved in immune response (GO:0002719)3.04175171
115T cell differentiation involved in immune response (GO:0002292)3.01676404
116alpha-beta T cell differentiation involved in immune response (GO:0002293)3.01676404
117alpha-beta T cell activation involved in immune response (GO:0002287)3.01676404
118interferon-gamma production (GO:0032609)3.00673890
119regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.98979406
120extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.98533099
121signal transduction in absence of ligand (GO:0038034)2.98533099
122thymic T cell selection (GO:0045061)2.98039046
123mature B cell differentiation (GO:0002335)2.97954826
124heterotypic cell-cell adhesion (GO:0034113)2.95194319
125antigen processing and presentation of endogenous antigen (GO:0019883)2.94254524
126negative regulation of T-helper cell differentiation (GO:0045623)2.94039204
127negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94039204
128meiotic chromosome segregation (GO:0045132)2.92047374
129negative regulation of adaptive immune response (GO:0002820)2.90540844
130negative T cell selection (GO:0043383)2.89653704
131chemokine-mediated signaling pathway (GO:0070098)2.88966241
132positive regulation of epithelial cell differentiation (GO:0030858)2.88619948
133phenol-containing compound biosynthetic process (GO:0046189)2.88606996
134* regulation of B cell activation (GO:0050864)2.88489699
135NIK/NF-kappaB signaling (GO:0038061)2.87805952
136regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.86897504
137regulation of tolerance induction (GO:0002643)2.84948358
138positive regulation of phospholipase C activity (GO:0010863)2.84715813
139negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81365964
140regulation of interleukin-5 production (GO:0032674)2.81241963
141mature B cell differentiation involved in immune response (GO:0002313)2.81093797
142cell wall macromolecule catabolic process (GO:0016998)2.80470073
143negative regulation of myeloid leukocyte differentiation (GO:0002762)2.80375938
144* regulation of JAK-STAT cascade (GO:0046425)2.76444068
145positive regulation of cytokine biosynthetic process (GO:0042108)2.75665453
146mitochondrial RNA metabolic process (GO:0000959)2.75408865
147regulation of isotype switching to IgG isotypes (GO:0048302)2.74198175
148regulation of alpha-beta T cell differentiation (GO:0046637)2.73455927
149regulation of phospholipase C activity (GO:1900274)2.71125696
150negative regulation of osteoclast differentiation (GO:0045671)2.70821278
151muscle organ morphogenesis (GO:0048644)2.69974751
152negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.68594791
153response to superoxide (GO:0000303)2.68236187
154T cell selection (GO:0045058)2.67701608
155positive regulation of lymphocyte mediated immunity (GO:0002708)2.67534779
156regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.67153686
157lymphocyte mediated immunity (GO:0002449)2.65998224
158regulation of DNA recombination (GO:0000018)2.64316566
159positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.62985060
160response to oxygen radical (GO:0000305)2.52759112
161positive regulation of macrophage activation (GO:0043032)18.7753607
162regulation of proton transport (GO:0010155)12.2794358
163positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)10.9509041
164negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)10.3582099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.10620239
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.89918152
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.75544526
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.38580667
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.33353307
6RUNX_20019798_ChIP-Seq_JUKART_Human4.30488012
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.00934124
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86907723
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.75997629
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.73439658
11SRY_22984422_ChIP-ChIP_TESTIS_Rat3.47124789
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46265677
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38935318
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.33211894
15STAT4_19710469_ChIP-ChIP_TH1__Mouse3.06474607
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.05993744
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.75989383
18MAF_26560356_Chip-Seq_TH1_Human2.75894927
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.60022994
20GATA1_19941826_ChIP-Seq_K562_Human2.54838111
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50042601
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42274247
23MYC_22102868_ChIP-Seq_BL_Human2.42078262
24* MYB_26560356_Chip-Seq_TH2_Human2.41429933
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.29457175
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29017957
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24215387
28VDR_21846776_ChIP-Seq_THP-1_Human2.21838876
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.20965623
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18057330
31KDM2B_26808549_Chip-Seq_DND41_Human2.13715517
32MYC_18555785_ChIP-Seq_MESCs_Mouse2.12825614
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07947438
34VDR_24763502_ChIP-Seq_THP-1_Human2.07384314
35VDR_23849224_ChIP-Seq_CD4+_Human2.05013512
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98795107
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.96727429
38FOXP3_21729870_ChIP-Seq_TREG_Human1.96485270
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93639329
40TAF15_26573619_Chip-Seq_HEK293_Human1.93307384
41IRF1_19129219_ChIP-ChIP_H3396_Human1.92192576
42MYB_26560356_Chip-Seq_TH1_Human1.90430544
43UTX_26944678_Chip-Seq_JUKART_Human1.90258098
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90203039
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88968326
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.87000388
47MAF_26560356_Chip-Seq_TH2_Human1.86384354
48TCF7_22412390_ChIP-Seq_EML_Mouse1.86152697
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85175391
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84697848
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83344492
52FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.82595550
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.81464615
54* GATA3_26560356_Chip-Seq_TH2_Human1.74989166
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72851291
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.72610692
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71563955
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71052523
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70321942
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69192570
61DCP1A_22483619_ChIP-Seq_HELA_Human1.65839900
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65753729
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64920114
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64498047
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.64350325
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.64318495
67POU5F1_16518401_ChIP-PET_MESCs_Mouse1.62977878
68GATA3_27048872_Chip-Seq_THYMUS_Human1.62548676
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58630408
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.58611444
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.55476838
72VDR_24787735_ChIP-Seq_THP-1_Human1.55132217
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50037488
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49358714
75LXR_22292898_ChIP-Seq_THP-1_Human1.47402574
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44118825
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44026304
78GATA2_19941826_ChIP-Seq_K562_Human1.43895466
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42853778
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42540737
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40134922
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39234064
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39169703
84SCL_19346495_ChIP-Seq_HPC-7_Human1.38209377
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.36748363
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35590820
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32820368
88DROSHA_22980978_ChIP-Seq_HELA_Human1.32456773
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30726726
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30143014
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28095433
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27688032
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24680271
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24366608
95EWS_26573619_Chip-Seq_HEK293_Human1.24047196
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.22762471
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22468972
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20963856
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.20798304
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20730054
101LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19494477
102EGR1_19032775_ChIP-ChIP_M12_Human1.18275802
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17990817
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.17421067
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14246868
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12852827
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11961655
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11612850
109SPI1_23127762_ChIP-Seq_K562_Human1.10533303
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10417124
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08226981
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07857858
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06615365
114PU_27001747_Chip-Seq_BMDM_Mouse1.06018097
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05782956
116TTF2_22483619_ChIP-Seq_HELA_Human1.04414801
117E2F7_22180533_ChIP-Seq_HELA_Human1.03314027
118E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03097570
119IRF8_27001747_Chip-Seq_BMDM_Mouse1.02737837
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02490771
121NCOR1_26117541_ChIP-Seq_K562_Human1.02098762
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01109012
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00775824
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00669002
125GATA1_19941827_ChIP-Seq_MEL_Mouse1.00162562
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.99761242
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98990182
128RACK7_27058665_Chip-Seq_MCF-7_Human0.98707946
129RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98584177
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.98553595
131SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.98208076
132SPI1_23547873_ChIP-Seq_NB4_Human0.96929512
133ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96084362
134TAF2_19829295_ChIP-Seq_ESCs_Human0.95740135
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95464027
136SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95181832
137TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94917450
138ERG_20517297_ChIP-Seq_VCAP_Human0.94269063
139SALL4_22934838_ChIP-ChIP_CD34+_Human0.94005755
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92266788
141TP53_22573176_ChIP-Seq_HFKS_Human0.92256527
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.92154244
143ELK1_19687146_ChIP-ChIP_HELA_Human0.91970538
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91898772
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89624574
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89323643
147LXR_22158963_ChIP-Seq_LIVER_Mouse0.88027975
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87150672
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85233619
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84776350
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84077140
152ER_23166858_ChIP-Seq_MCF-7_Human0.84045617
153EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83990851
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83118869
155MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82335536
156ZNF263_19887448_ChIP-Seq_K562_Human0.82038548
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.81390154
158KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81351552
159RXR_22158963_ChIP-Seq_LIVER_Mouse0.81347872
160PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80516161
161PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79294888
162GATA3_21878914_ChIP-Seq_MCF-7_Human0.78538371
163YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78384477
164WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78021807
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77999835
166FUS_26573619_Chip-Seq_HEK293_Human0.77827289
167* GATA3_26560356_Chip-Seq_TH1_Human0.77674662
168TP63_19390658_ChIP-ChIP_HaCaT_Human0.77604532
169KDM2B_26808549_Chip-Seq_K562_Human0.77389146
170MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77088404
171MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77039973
172RARB_24833708_ChIP-Seq_LIVER_Mouse0.76836405
173P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76479068
174BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76403078
175PPARA_22158963_ChIP-Seq_LIVER_Mouse0.75243831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003045_fibrosis8.07588322
2MP0005671_abnormal_response_to4.83377713
3MP0004510_myositis4.61601355
4MP0008875_abnormal_xenobiotic_pharmacok4.32791531
5MP0001835_abnormal_antigen_presentation4.27960877
6MP0003300_gastrointestinal_ulcer4.05964593
7MP0008775_abnormal_heart_ventricle3.81355638
8MP0003303_peritoneal_inflammation3.67497045
9MP0005387_immune_system_phenotype3.42900588
10MP0001790_abnormal_immune_system3.42900588
11MP0002168_other_aberrant_phenotype3.03027249
12MP0002733_abnormal_thermal_nociception3.00346857
13MP0005166_decreased_susceptibility_to2.88970989
14MP0003724_increased_susceptibility_to2.74846194
15* MP0001800_abnormal_humoral_immune2.38475162
16MP0005000_abnormal_immune_tolerance2.34119939
17MP0002009_preneoplasia2.13067195
18MP0001970_abnormal_pain_threshold2.08274975
19MP0009333_abnormal_splenocyte_physiolog2.07832559
20MP0005623_abnormal_meninges_morphology2.01002672
21MP0005451_abnormal_body_composition1.97346952
22MP0000685_abnormal_immune_system1.94888993
23MP0002452_abnormal_antigen_presenting1.84154854
24* MP0005025_abnormal_response_to1.79883375
25MP0003866_abnormal_defecation1.79486521
26* MP0002723_abnormal_immune_serum1.76951910
27MP0003638_abnormal_response/metabolism_1.74397306
28MP0005076_abnormal_cell_differentiation1.70680202
29MP0003763_abnormal_thymus_physiology1.67756154
30MP0002398_abnormal_bone_marrow1.66675280
31* MP0001819_abnormal_immune_cell1.66650600
32MP0004947_skin_inflammation1.66481623
33* MP0002420_abnormal_adaptive_immunity1.65269606
34MP0006082_CNS_inflammation1.59601259
35MP0003436_decreased_susceptibility_to1.57849233
36MP0000716_abnormal_immune_system1.52372686
37MP0005310_abnormal_salivary_gland1.48690024
38MP0002396_abnormal_hematopoietic_system1.47247606
39MP0000465_gastrointestinal_hemorrhage1.47113483
40MP0005395_other_phenotype1.44563784
41MP0001845_abnormal_inflammatory_respons1.36775414
42MP0001873_stomach_inflammation1.36409516
43MP0010155_abnormal_intestine_physiology1.32909214
44MP0008872_abnormal_physiological_respon1.24511000
45MP0002722_abnormal_immune_system1.23450114
46MP0000703_abnormal_thymus_morphology1.21304067
47MP0001853_heart_inflammation1.19732078
48MP0005501_abnormal_skin_physiology1.19011632
49* MP0002429_abnormal_blood_cell1.15473924
50MP0004084_abnormal_cardiac_muscle1.14852003
51MP0005464_abnormal_platelet_physiology1.14585039
52MP0009785_altered_susceptibility_to1.13871902
53* MP0000477_abnormal_intestine_morphology1.11411752
54MP0002933_joint_inflammation1.08944090
55MP0002419_abnormal_innate_immunity1.07627739
56MP0002277_abnormal_respiratory_mucosa1.05675671
57MP0002998_abnormal_bone_remodeling1.04526932
58MP0010234_abnormal_vibrissa_follicle1.03480101
59MP0001984_abnormal_olfaction1.03186744
60MP0003448_altered_tumor_morphology1.02560931
61MP0005381_digestive/alimentary_phenotyp1.01139041
62MP0001533_abnormal_skeleton_physiology1.00565480
63MP0001348_abnormal_lacrimal_gland0.98082910
64MP0004742_abnormal_vestibular_system0.95402559
65MP0002693_abnormal_pancreas_physiology0.94805617
66MP0002909_abnormal_adrenal_gland0.94320306
67MP0004924_abnormal_behavior0.93118115
68MP0005386_behavior/neurological_phenoty0.93118115
69MP0003718_maternal_effect0.92707535
70MP0002166_altered_tumor_susceptibility0.92038675
71MP0001851_eye_inflammation0.90371636
72MP0005023_abnormal_wound_healing0.89058452
73MP0002405_respiratory_system_inflammati0.88388155
74MP0002163_abnormal_gland_morphology0.88115989
75MP0003566_abnormal_cell_adhesion0.82441720
76MP0000689_abnormal_spleen_morphology0.81469576
77MP0009765_abnormal_xenobiotic_induced0.79961068
78MP0006072_abnormal_retinal_apoptosis0.78047475
79MP0005165_increased_susceptibility_to0.77739304
80MP0005319_abnormal_enzyme/_coenzyme0.75805436
81MP0005645_abnormal_hypothalamus_physiol0.73757926
82MP0004808_abnormal_hematopoietic_stem0.71935930
83MP0003186_abnormal_redox_activity0.70501057
84MP0003191_abnormal_cellular_cholesterol0.70276980
85MP0009840_abnormal_foam_cell0.68847763
86MP0000013_abnormal_adipose_tissue0.67723667
87MP0005085_abnormal_gallbladder_physiolo0.67587581
88MP0001765_abnormal_ion_homeostasis0.67426409
89MP0008058_abnormal_DNA_repair0.67407140
90MP0001881_abnormal_mammary_gland0.65390419
91* MP0008469_abnormal_protein_level0.65244731
92MP0000490_abnormal_crypts_of0.64062770
93MP0000858_altered_metastatic_potential0.62311124
94MP0002139_abnormal_hepatobiliary_system0.62247872
95MP0003075_altered_response_to0.60682288
96MP0008877_abnormal_DNA_methylation0.60665537
97MP0001986_abnormal_taste_sensitivity0.60321659
98MP0005584_abnormal_enzyme/coenzyme_acti0.59213771
99MP0008873_increased_physiological_sensi0.57874843
100MP0009763_increased_sensitivity_to0.56871094
101MP0001663_abnormal_digestive_system0.55959079
102MP0000249_abnormal_blood_vessel0.54594623
103MP0000427_abnormal_hair_cycle0.53879168
104MP0003091_abnormal_cell_migration0.53120077
105MP0002138_abnormal_hepatobiliary_system0.53035380
106MP0004085_abnormal_heartbeat0.52460349
107MP0005379_endocrine/exocrine_gland_phen0.51731013
108MP0004859_abnormal_synaptic_plasticity0.51267462
109MP0003329_amyloid_beta_deposits0.50974530
110MP0002972_abnormal_cardiac_muscle0.50924664
111MP0002877_abnormal_melanocyte_morpholog0.50833513
112MP0005360_urolithiasis0.50336673
113MP0002148_abnormal_hypersensitivity_rea0.50289786
114MP0002332_abnormal_exercise_endurance0.49529889
115MP0002006_tumorigenesis0.48944422
116MP0004036_abnormal_muscle_relaxation0.48637111
117MP0008057_abnormal_DNA_replication0.47474561
118MP0000313_abnormal_cell_death0.45785535
119MP0003795_abnormal_bone_structure0.45645535
120MP0001502_abnormal_circadian_rhythm0.45517440
121MP0001545_abnormal_hematopoietic_system0.45498363
122MP0005397_hematopoietic_system_phenotyp0.45498363
123MP0004185_abnormal_adipocyte_glucose0.45385851
124MP0000604_amyloidosis0.44144798
125MP0003646_muscle_fatigue0.43899337
126MP0003880_abnormal_central_pattern0.43670291
127MP0000383_abnormal_hair_follicle0.42314849
128MP0010771_integument_phenotype0.42178796
129MP0002019_abnormal_tumor_incidence0.41906917
130MP0005636_abnormal_mineral_homeostasis0.39266712
131MP0009931_abnormal_skin_appearance0.38962838
132MP0001501_abnormal_sleep_pattern0.38498190
133MP0008770_decreased_survivor_rate0.38012986
134MP0003453_abnormal_keratinocyte_physiol0.37704161
135MP0010352_gastrointestinal_tract_polyps0.37544595
136MP0009764_decreased_sensitivity_to0.37293603
137MP0001727_abnormal_embryo_implantation0.37191132
138MP0000733_abnormal_muscle_development0.37099033
139MP0000609_abnormal_liver_physiology0.36706075
140MP0010329_abnormal_lipoprotein_level0.36445027
141MP0004142_abnormal_muscle_tone0.35794963
142MP0003786_premature_aging0.35628052
143MP0009379_abnormal_foot_pigmentation0.33936449
144MP0003567_abnormal_fetal_cardiomyocyte0.30490363

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)7.22869619
2B lymphocytopenia (HP:0010976)6.94915049
3Abnormality of B cell number (HP:0010975)6.94915049
4Large for gestational age (HP:0001520)6.65582890
5Recurrent bronchitis (HP:0002837)5.33448918
6IgA deficiency (HP:0002720)4.74946535
7Myositis (HP:0100614)4.58369745
8Progressive muscle weakness (HP:0003323)4.52911924
9Hypoplasia of the ulna (HP:0003022)4.49684019
10Abnormality of T cell physiology (HP:0011840)4.44259776
11Gingival bleeding (HP:0000225)4.42025927
12Petechiae (HP:0000967)4.34410088
13Abnormal pupillary function (HP:0007686)4.20668209
14Aplasia/Hypoplasia of the ulna (HP:0006495)4.16670859
15Retrobulbar optic neuritis (HP:0100654)4.16323569
16Optic neuritis (HP:0100653)4.16323569
17Ependymoma (HP:0002888)4.07401759
18Fibular aplasia (HP:0002990)4.06623702
19Gastrointestinal stroma tumor (HP:0100723)4.03858102
20Abnormality of T cells (HP:0002843)4.01246562
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.93841561
22Paralysis (HP:0003470)3.83335875
23Purpura (HP:0000979)3.80363965
24Colon cancer (HP:0003003)3.75219351
25Abnormal platelet volume (HP:0011876)3.69766851
26Orchitis (HP:0100796)3.56946726
27Forearm undergrowth (HP:0009821)3.52874255
28Increased hepatocellular lipid droplets (HP:0006565)3.52371971
29Vasculitis (HP:0002633)3.46843923
30Increased mean platelet volume (HP:0011877)3.41732765
31Spinal cord lesions (HP:0100561)3.39443107
32Syringomyelia (HP:0003396)3.39443107
33Radial bowing (HP:0002986)3.37899754
34Pulmonary embolism (HP:0002204)3.26769623
35T lymphocytopenia (HP:0005403)3.24452441
36Lipid accumulation in hepatocytes (HP:0006561)3.23723506
37Recurrent sinusitis (HP:0011108)3.22041362
38Deep philtrum (HP:0002002)3.11235450
39Eczematoid dermatitis (HP:0000976)3.09699118
40Exertional dyspnea (HP:0002875)3.09213307
41Enlarged epiphyses (HP:0010580)3.08610608
42Arterial thrombosis (HP:0004420)3.08170426
43Adactyly (HP:0009776)3.07485151
44Abnormality of T cell number (HP:0011839)3.07029561
45Cerebral hemorrhage (HP:0001342)3.06824118
46Aplastic anemia (HP:0001915)3.04633850
47Pendular nystagmus (HP:0012043)3.01301306
48Abnormal platelet function (HP:0011869)2.96524100
49Impaired platelet aggregation (HP:0003540)2.96524100
50Keratoconjunctivitis sicca (HP:0001097)2.96095463
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.94141977
52Panhypogammaglobulinemia (HP:0003139)2.87771791
53Limb hypertonia (HP:0002509)2.80294528
54Bronchitis (HP:0012387)2.79336121
55Recurrent fungal infections (HP:0002841)2.77441058
56Prolonged bleeding time (HP:0003010)2.76759428
57Elevated erythrocyte sedimentation rate (HP:0003565)2.72916388
58Increased IgE level (HP:0003212)2.69035134
59Epistaxis (HP:0000421)2.67206548
60Chronic diarrhea (HP:0002028)2.65784299
61Keratoconjunctivitis (HP:0001096)2.65679309
62Progressive microcephaly (HP:0000253)2.64158907
63Spontaneous hematomas (HP:0007420)2.63999054
64Cavernous hemangioma (HP:0001048)2.63040742
65Decreased central vision (HP:0007663)2.59740665
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59223712
67Lymphopenia (HP:0001888)2.57732652
68Microvesicular hepatic steatosis (HP:0001414)2.57280396
69Joint swelling (HP:0001386)2.55750414
70Chronic otitis media (HP:0000389)2.55110855
71Astrocytoma (HP:0009592)2.53605081
72Abnormality of the astrocytes (HP:0100707)2.53605081
73Interstitial pulmonary disease (HP:0006530)2.53411178
74Menorrhagia (HP:0000132)2.52724434
75Abnormal rod and cone electroretinograms (HP:0008323)2.51536316
76Respiratory difficulties (HP:0002880)2.51072787
77Restrictive lung disease (HP:0002091)2.50641068
78Emphysema (HP:0002097)2.46286460
79Increased serum lactate (HP:0002151)2.45392510
80Mitral stenosis (HP:0001718)2.42259667
81IgG deficiency (HP:0004315)2.41913286
82Abnormality of cells of the lymphoid lineage (HP:0012140)2.41792180
83Hypercalciuria (HP:0002150)2.40772809
84Abnormality of glycolipid metabolism (HP:0010969)2.40113657
85Abnormality of liposaccharide metabolism (HP:0010968)2.40113657
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.40113657
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.37075675
88Hypoalbuminemia (HP:0003073)2.36897376
89Abnormal albumin level (HP:0012116)2.36897376
90Abnormality of binocular vision (HP:0011514)2.36468801
91Diplopia (HP:0000651)2.36468801
92Pulmonary infiltrates (HP:0002113)2.35046805
93Renal Fanconi syndrome (HP:0001994)2.32902405
94Chest pain (HP:0100749)2.32542107
95Gastrointestinal infarctions (HP:0005244)2.31818131
96Gangrene (HP:0100758)2.30691788
97Mediastinal lymphadenopathy (HP:0100721)2.29361333
98Angiofibromas (HP:0010615)2.27151575
99Adenoma sebaceum (HP:0009720)2.27151575
100Deep venous thrombosis (HP:0002625)2.26973353
101Urticaria (HP:0001025)2.26964375
102Increased intramyocellular lipid droplets (HP:0012240)2.26797975
103Thrombocytosis (HP:0001894)2.26091776
104Anorexia (HP:0002039)2.25871908
105Polycythemia (HP:0001901)2.22778564
106Abnormality of midbrain morphology (HP:0002418)2.21865165
107Molar tooth sign on MRI (HP:0002419)2.21865165
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21096204
109Severe combined immunodeficiency (HP:0004430)2.19320314
110Aplasia/Hypoplasia of the tibia (HP:0005772)2.17907372
111Hemiplegia (HP:0002301)2.17896624
112Neuroblastic tumors (HP:0004376)2.16247455
113Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.16247455
114Neuroblastoma (HP:0003006)2.16247455
115Primitive neuroectodermal tumor (HP:0030065)2.16247455
116Obstructive lung disease (HP:0006536)2.16181777
117Chronic obstructive pulmonary disease (HP:0006510)2.16181777
118Pheochromocytoma (HP:0002666)2.14664326
119Short tibia (HP:0005736)2.14569719
120Neoplasm of the small intestine (HP:0100833)2.14271757
121Hamartoma of the eye (HP:0010568)2.11804283
122Arthralgia (HP:0002829)2.11797436
123Thrombophlebitis (HP:0004418)2.11357940
124Septate vagina (HP:0001153)2.10766326
125Recurrent viral infections (HP:0004429)2.09125347
126Increased CSF lactate (HP:0002490)2.08457715
127Aplasia/hypoplasia of the uterus (HP:0008684)2.07883533
128Nasal polyposis (HP:0100582)2.07409240
129Polyneuropathy (HP:0001271)2.06723216
130Meningitis (HP:0001287)2.04424264
131Increased muscle lipid content (HP:0009058)2.03131453
1323-Methylglutaconic aciduria (HP:0003535)2.00373478
133Bony spicule pigmentary retinopathy (HP:0007737)1.98938975
134Fatigue (HP:0012378)1.98766808
135Hemoptysis (HP:0002105)1.97739361
136Combined immunodeficiency (HP:0005387)1.97382463
137Thyroid-stimulating hormone excess (HP:0002925)1.97362495
138Hypoplasia of the pons (HP:0012110)1.97175311
139Portal hypertension (HP:0001409)1.94211506
140Alveolar cell carcinoma (HP:0006519)1.92389921
141Basal cell carcinoma (HP:0002671)1.91068229
142Vacuolated lymphocytes (HP:0001922)1.90360722
143Vertebral fusion (HP:0002948)1.89552269
144Synostosis involving the elbow (HP:0003938)1.89010721
145Humeroradial synostosis (HP:0003041)1.89010721
146Encephalitis (HP:0002383)1.88397109
147Stomatitis (HP:0010280)1.88288384
1482-3 toe syndactyly (HP:0004691)1.87653707
149Neuroendocrine neoplasm (HP:0100634)1.87533188
150Biliary tract neoplasm (HP:0100574)1.86806862
151Abnormality of the pons (HP:0007361)1.86241849
152Glioma (HP:0009733)1.85974267
153Abdominal pain (HP:0002027)1.85344917
154Pustule (HP:0200039)1.84961430
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83830779
156Short 1st metacarpal (HP:0010034)1.83830779
157Myoglobinuria (HP:0002913)1.83641360
158Abnormality of the proximal phalanges of the hand (HP:0009834)1.83552354
159Inflammation of the large intestine (HP:0002037)1.83527172
160Exercise intolerance (HP:0003546)1.82583263
161Striae distensae (HP:0001065)1.82513782
162Dysmetric saccades (HP:0000641)1.82105893
163Aortic aneurysm (HP:0004942)1.80662441
164Gastrointestinal inflammation (HP:0004386)1.80524100
165Abnormal gallbladder physiology (HP:0012438)1.80499230
166Cholecystitis (HP:0001082)1.80499230
167Hypoplasia of the radius (HP:0002984)1.79037276
168Abnormality of the nasal mucosa (HP:0000433)1.78244200
169Apathy (HP:0000741)1.78091776
170Cervical subluxation (HP:0003308)1.76690196
171Disproportionate tall stature (HP:0001519)1.75433675
172Increased density of long bones (HP:0006392)1.74619250
173Abnormality of the Achilles tendon (HP:0005109)1.73882126
174Arterial tortuosity (HP:0005116)1.69136243
175Spondylolisthesis (HP:0003302)1.68934628
176Achilles tendon contracture (HP:0001771)1.68780499
177Abnormality of the lumbar spine (HP:0100712)1.68297718
178Diminished motivation (HP:0000745)1.63831190
179Lymphoma (HP:0002665)1.63483077
180Cerebral aneurysm (HP:0004944)1.61774742
181Recurrent otitis media (HP:0000403)1.61402841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD45.61752959
2MAP4K15.31540563
3TAOK33.41246475
4JAK13.36634150
5TSSK63.33935830
6BLK3.33771825
7TXK3.32179076
8PIK3CG3.14960006
9TRIB33.14683112
10EIF2AK12.96738360
11SRPK12.73235549
12GRK62.65979297
13JAK32.47495399
14MST42.40942059
15FES2.33707577
16STK42.29713198
17TNIK2.27926348
18PKN22.27681736
19ZAP702.25170709
20PBK11.8768929
21STK101.96340384
22CDK61.95608559
23SYK1.91359665
24ALK1.90453722
25EPHB11.85845188
26LRRK21.78388097
27ITK1.76949970
28SIK21.64350087
29HCK1.55431896
30PDK11.52441732
31PDPK11.49733126
32TEC1.41247354
33PRKCQ1.34595971
34STK38L1.33118382
35BTK1.29064764
36TYK21.29052048
37EPHA31.27801506
38CSF1R1.26633219
39FGFR41.24128028
40DMPK1.22525858
41CDK41.21268353
42PTK21.17048906
43SIK11.16564797
44BMX1.15228733
45LCK1.13956852
46TBK11.12245776
47NLK1.11449851
48JAK21.09655870
49TGFBR21.08672438
50CAMKK21.07370550
51STK241.06056600
52ILK0.99061269
53ADRBK20.99001906
54HIPK20.98600272
55TNK20.97489763
56MAP3K120.94516175
57EIF2AK30.94019745
58PRKCH0.91980430
59TLK10.91690776
60NME10.90366390
61EEF2K0.89274482
62IKBKB0.87238062
63PASK0.86489675
64WNK40.84680759
65PIM10.83919858
66NEK20.83855701
67DAPK20.81441239
68TAOK10.80840432
69CDK90.80391021
70PTK60.79026725
71ROCK20.76514412
72VRK20.73694500
73PAK60.72729181
74PRKACG0.71916503
75GSK3A0.68886733
76AKT30.66861169
77EIF2AK20.66115566
78FGFR10.65372610
79CAMKK10.64618337
80SCYL20.64252769
81MAP3K70.64198439
82RET0.63153110
83CAMK1D0.62881524
84FGFR30.60900236
85STK390.60748924
86MAP2K60.59802350
87FGR0.59238785
88MAP3K140.58872885
89MAP3K130.57040987
90KDR0.56701029
91WNK10.56525739
92PDGFRB0.56287040
93LYN0.55448510
94PAK30.54359515
95MKNK20.51831668
96TESK20.50022677
97STK30.49189451
98MARK30.48932728
99LIMK10.46633947
100NME20.46551325
101IKBKE0.46527727
102ERBB40.46112219
103FYN0.45850468
104ERN10.45673283
105PRKG20.44146149
106CSK0.44033743
107TGFBR10.43706347
108SRC0.43189863
109CLK10.43098063
110KSR20.43016381
111MAPK40.42393832
112DAPK30.42267566
113CDK50.41838766
114MYLK0.40656226
115MAP3K100.40598085
116RPS6KA30.39731720
117CDK150.39593853
118KIT0.39518397
119PKN10.39384680
120CDK180.37906981
121PIK3CA0.37599261
122RIPK10.37514811
123UHMK10.37412921
124NTRK20.36789914
125CHUK0.36755814
126NTRK10.36462682
127ERBB20.36323345
128MATK0.35154958
129CDK11A0.34150862
130MAP3K50.32151651
131TYRO30.31711463
132CDK140.30779508
133MKNK10.30498124
134IRAK10.29811557
135PRKCD0.29069399
136MAP3K80.28780749
137RPS6KB10.27162398
138BCKDK0.26309522
139GRK70.26081785
140IRAK40.26025549
141MAP3K110.26010207
142RPS6KA10.24211371
143MAPK110.22962461
144MAP2K20.22853587
145CAMK2G0.22623442
146ADRBK10.22540172
147FRK0.21034414
148BMPR20.19296399
149MELK0.16141304
150CDK80.16112116
151CAMK1G0.15584968
152PTK2B0.15459505
153NEK90.13629231
154CAMK40.12549641
155BMPR1B0.12147084
156IGF1R0.11175376
157RPS6KA50.10486503

Predicted pathways (KEGG)

RankGene SetZ-score
1* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.29129429
2* Intestinal immune network for IgA production_Homo sapiens_hsa046722.99373370
3RNA polymerase_Homo sapiens_hsa030202.92030180
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.88792952
5* Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.76159562
6* Jak-STAT signaling pathway_Homo sapiens_hsa046302.59002351
7* Allograft rejection_Homo sapiens_hsa053302.21310801
8Tryptophan metabolism_Homo sapiens_hsa003802.20703719
9Measles_Homo sapiens_hsa051622.13907502
10Nitrogen metabolism_Homo sapiens_hsa009102.11567271
11* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.00229748
12* Asthma_Homo sapiens_hsa0531011.5913746
13Primary immunodeficiency_Homo sapiens_hsa053401.95698465
14Proteasome_Homo sapiens_hsa030501.83242744
15* Autoimmune thyroid disease_Homo sapiens_hsa053201.82465981
16* T cell receptor signaling pathway_Homo sapiens_hsa046601.64063899
17Vitamin B6 metabolism_Homo sapiens_hsa007501.52077011
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47978923
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40313418
20* Hematopoietic cell lineage_Homo sapiens_hsa046401.36818394
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30852120
22Mismatch repair_Homo sapiens_hsa034301.29391407
23Caffeine metabolism_Homo sapiens_hsa002321.15067320
24Leishmaniasis_Homo sapiens_hsa051401.13649726
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08596317
26One carbon pool by folate_Homo sapiens_hsa006701.08145247
27Staphylococcus aureus infection_Homo sapiens_hsa051501.07647430
28Osteoclast differentiation_Homo sapiens_hsa043800.99861871
29B cell receptor signaling pathway_Homo sapiens_hsa046620.88387382
30Type I diabetes mellitus_Homo sapiens_hsa049400.87569358
31Toxoplasmosis_Homo sapiens_hsa051450.83920860
32Graft-versus-host disease_Homo sapiens_hsa053320.82942111
33Renal cell carcinoma_Homo sapiens_hsa052110.81263536
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79954800
35NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79592557
36Platelet activation_Homo sapiens_hsa046110.79150759
37Chemokine signaling pathway_Homo sapiens_hsa040620.78794692
38Spliceosome_Homo sapiens_hsa030400.78434984
39Type II diabetes mellitus_Homo sapiens_hsa049300.77434251
40Fanconi anemia pathway_Homo sapiens_hsa034600.73683264
41Serotonergic synapse_Homo sapiens_hsa047260.72337317
42Chronic myeloid leukemia_Homo sapiens_hsa052200.71622806
43RNA transport_Homo sapiens_hsa030130.68342411
44Pyrimidine metabolism_Homo sapiens_hsa002400.66618715
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63674669
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62996712
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62984887
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62451875
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.61006085
50Apoptosis_Homo sapiens_hsa042100.58464448
51Prolactin signaling pathway_Homo sapiens_hsa049170.57268006
52Shigellosis_Homo sapiens_hsa051310.55721345
53Acute myeloid leukemia_Homo sapiens_hsa052210.55617593
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55574442
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55177164
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54934016
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54094568
58Non-small cell lung cancer_Homo sapiens_hsa052230.53963578
59Long-term potentiation_Homo sapiens_hsa047200.52159605
60Mineral absorption_Homo sapiens_hsa049780.51330990
61Amoebiasis_Homo sapiens_hsa051460.50981998
62Steroid biosynthesis_Homo sapiens_hsa001000.50685558
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.49200404
64Dilated cardiomyopathy_Homo sapiens_hsa054140.48903704
65Other glycan degradation_Homo sapiens_hsa005110.46728036
66Arginine biosynthesis_Homo sapiens_hsa002200.46726462
67TNF signaling pathway_Homo sapiens_hsa046680.46634413
68RNA degradation_Homo sapiens_hsa030180.46512217
69FoxO signaling pathway_Homo sapiens_hsa040680.46433079
70African trypanosomiasis_Homo sapiens_hsa051430.45864861
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.45753054
72Herpes simplex infection_Homo sapiens_hsa051680.45402771
73Pancreatic cancer_Homo sapiens_hsa052120.45117803
74Non-homologous end-joining_Homo sapiens_hsa034500.44792461
75Sulfur metabolism_Homo sapiens_hsa009200.44134641
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44032386
77Arginine and proline metabolism_Homo sapiens_hsa003300.43133070
78Influenza A_Homo sapiens_hsa051640.42572565
79Hepatitis C_Homo sapiens_hsa051600.42088035
80Epstein-Barr virus infection_Homo sapiens_hsa051690.41624869
81VEGF signaling pathway_Homo sapiens_hsa043700.40778321
82Collecting duct acid secretion_Homo sapiens_hsa049660.39701314
83Dorso-ventral axis formation_Homo sapiens_hsa043200.39416543
84Viral myocarditis_Homo sapiens_hsa054160.38799164
85Homologous recombination_Homo sapiens_hsa034400.38264017
86Small cell lung cancer_Homo sapiens_hsa052220.38056567
87Antigen processing and presentation_Homo sapiens_hsa046120.37630253
88HIF-1 signaling pathway_Homo sapiens_hsa040660.37309123
89Nucleotide excision repair_Homo sapiens_hsa034200.36675293
90Ovarian steroidogenesis_Homo sapiens_hsa049130.36247576
91Purine metabolism_Homo sapiens_hsa002300.36160684
92Peroxisome_Homo sapiens_hsa041460.35446832
93Hepatitis B_Homo sapiens_hsa051610.35351763
94Glioma_Homo sapiens_hsa052140.34720854
95Proteoglycans in cancer_Homo sapiens_hsa052050.34627173
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.34432240
97Linoleic acid metabolism_Homo sapiens_hsa005910.32921591
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32763788
99Phototransduction_Homo sapiens_hsa047440.32365671
100MAPK signaling pathway_Homo sapiens_hsa040100.31772940
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.31413805
102Insulin resistance_Homo sapiens_hsa049310.29930060
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29696586
104Focal adhesion_Homo sapiens_hsa045100.29108433
105Viral carcinogenesis_Homo sapiens_hsa052030.29082782
106Legionellosis_Homo sapiens_hsa051340.29025633
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28978723
108Pertussis_Homo sapiens_hsa051330.28694220
109MicroRNAs in cancer_Homo sapiens_hsa052060.28118351
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27975579
111Insulin signaling pathway_Homo sapiens_hsa049100.26609370
112Propanoate metabolism_Homo sapiens_hsa006400.26407178
113Endocytosis_Homo sapiens_hsa041440.25860732
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25423464
115Rap1 signaling pathway_Homo sapiens_hsa040150.24982335
116Tuberculosis_Homo sapiens_hsa051520.24161448
117Basal transcription factors_Homo sapiens_hsa030220.23810109
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23541932
119Vibrio cholerae infection_Homo sapiens_hsa051100.23198807
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23017162
121Protein export_Homo sapiens_hsa030600.22698064
122Estrogen signaling pathway_Homo sapiens_hsa049150.22668311
123Malaria_Homo sapiens_hsa051440.22568296
124HTLV-I infection_Homo sapiens_hsa051660.22533611
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22038244
126Oxidative phosphorylation_Homo sapiens_hsa001900.21684670
127Fatty acid biosynthesis_Homo sapiens_hsa000610.21462117
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.21420744
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21292245
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21191121
131Rheumatoid arthritis_Homo sapiens_hsa053230.20499053
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19981484
133DNA replication_Homo sapiens_hsa030300.19081427
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18976835
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18470081
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18332833
137Gastric acid secretion_Homo sapiens_hsa049710.17855607
138Circadian rhythm_Homo sapiens_hsa047100.17706043
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16538623
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.15705811
141Glucagon signaling pathway_Homo sapiens_hsa049220.15675731
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.15520011
143Morphine addiction_Homo sapiens_hsa050320.15361781
144Thyroid hormone synthesis_Homo sapiens_hsa049180.14319758
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13345928
146Butanoate metabolism_Homo sapiens_hsa006500.13339990
147Ribosome_Homo sapiens_hsa030100.13255006
148Salmonella infection_Homo sapiens_hsa051320.12992609
149Cholinergic synapse_Homo sapiens_hsa047250.12665774
150Renin secretion_Homo sapiens_hsa049240.12314042
151Biosynthesis of amino acids_Homo sapiens_hsa012300.11794961
152ECM-receptor interaction_Homo sapiens_hsa045120.11617585
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11068215
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10485567
155Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08530652
156Arachidonic acid metabolism_Homo sapiens_hsa005900.08512907
157mTOR signaling pathway_Homo sapiens_hsa041500.06127437
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03111359
159ABC transporters_Homo sapiens_hsa020100.00983280
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0367759
161Fatty acid degradation_Homo sapiens_hsa00071-0.0193379

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