IL5RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.67950147
2motile cilium assembly (GO:0044458)9.44797948
3axoneme assembly (GO:0035082)8.36932372
4regulation of cilium movement (GO:0003352)6.23615025
5left/right axis specification (GO:0070986)5.67201504
6left/right pattern formation (GO:0060972)4.87620332
7cilium organization (GO:0044782)4.57149905
8ventricular system development (GO:0021591)4.52311885
9tolerance induction (GO:0002507)4.45845495
10centriole assembly (GO:0098534)4.33969818
11superoxide anion generation (GO:0042554)4.32948922
12microtubule bundle formation (GO:0001578)4.30212183
13diol metabolic process (GO:0034311)4.29972574
14cilium assembly (GO:0042384)4.28240560
15sphingosine metabolic process (GO:0006670)4.12387632
16sphingoid metabolic process (GO:0046519)3.99414305
17negative regulation of mast cell activation (GO:0033004)3.94486524
18centriole replication (GO:0007099)3.88133210
19vitamin transmembrane transport (GO:0035461)3.87966770
20intraciliary transport (GO:0042073)3.80667912
21response to xenobiotic stimulus (GO:0009410)3.78812331
22negative regulation of B cell mediated immunity (GO:0002713)3.78232659
23negative regulation of immunoglobulin mediated immune response (GO:0002890)3.78232659
24protein localization to cilium (GO:0061512)3.72299014
25positive regulation of cellular amide metabolic process (GO:0034250)3.66995198
26regulation of tolerance induction (GO:0002643)3.62803859
27primary alcohol catabolic process (GO:0034310)3.60465024
28retinal cone cell development (GO:0046549)3.51658593
29pyrimidine-containing compound transmembrane transport (GO:0072531)3.50845812
30regulation of microtubule-based movement (GO:0060632)3.50468309
31polyketide metabolic process (GO:0030638)3.48391764
32doxorubicin metabolic process (GO:0044598)3.48391764
33daunorubicin metabolic process (GO:0044597)3.48391764
34cilium morphogenesis (GO:0060271)3.46920358
35regulation of B cell receptor signaling pathway (GO:0050855)3.39358617
36DNA methylation involved in gamete generation (GO:0043046)3.39049033
37cellular component assembly involved in morphogenesis (GO:0010927)3.37536043
38regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.32330543
39negative regulation of humoral immune response (GO:0002921)3.30930514
40one-carbon compound transport (GO:0019755)3.26457922
41B cell proliferation (GO:0042100)3.24302226
42B cell receptor signaling pathway (GO:0050853)3.17168612
43retinal rod cell development (GO:0046548)3.16380141
44diterpenoid biosynthetic process (GO:0016102)3.13705408
45DNA integration (GO:0015074)3.13395198
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13277556
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.11165585
48response to host immune response (GO:0052572)3.11165585
49phosphatidylethanolamine metabolic process (GO:0046337)3.10233684
50mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09559691
51mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09559691
52cell projection assembly (GO:0030031)3.09492892
53negative regulation of glycoprotein biosynthetic process (GO:0010561)3.09089922
54interferon-gamma production (GO:0032609)3.08380122
55detection of other organism (GO:0098543)3.07169824
56ethanol metabolic process (GO:0006067)3.06011969
57neutrophil activation (GO:0042119)3.04463535
58G-protein coupled receptor internalization (GO:0002031)3.03044050
59negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97917204
60regulation of meiosis I (GO:0060631)2.97627459
61positive regulation of tolerance induction (GO:0002645)2.94082153
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93748106
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.93748106
64modulation by symbiont of host immune response (GO:0052553)2.93748106
65positive regulation by symbiont of host defense response (GO:0052509)2.93748106
66modulation by symbiont of host defense response (GO:0052031)2.93748106
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93748106
68regulation of collateral sprouting (GO:0048670)2.93510068
69detection of bacterium (GO:0016045)2.93241359
70DNA strand renaturation (GO:0000733)2.92973286
71flavonoid metabolic process (GO:0009812)2.92668805
72positive regulation of gamma-delta T cell activation (GO:0046645)2.92105671
73protein-chromophore linkage (GO:0018298)2.92048377
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91605812
75phosphatidylethanolamine biosynthetic process (GO:0006646)2.89878584
76sulfation (GO:0051923)2.89351534
77regulation of protein glycosylation (GO:0060049)2.87390507
78adaptation of signaling pathway (GO:0023058)2.87172045
79positive regulation of mast cell activation (GO:0033005)2.87013737
80B cell homeostasis (GO:0001782)2.85766324
81negative regulation of T cell differentiation in thymus (GO:0033085)2.83952216
82regulation of B cell proliferation (GO:0030888)2.83926082
83hydrogen peroxide biosynthetic process (GO:0050665)2.83713174
84negative regulation of adaptive immune response (GO:0002820)2.81374538
85positive regulation of interleukin-1 beta secretion (GO:0050718)2.81217755
86regulation of interleukin-6 biosynthetic process (GO:0045408)2.80031319
87adenosine metabolic process (GO:0046085)2.79289160
88cellular response to zinc ion (GO:0071294)2.79064248
89postsynaptic membrane organization (GO:0001941)2.78021112
90mature B cell differentiation (GO:0002335)2.77857073
91negative regulation of B cell proliferation (GO:0030889)2.77048102
92energy homeostasis (GO:0097009)2.76680271
93exogenous drug catabolic process (GO:0042738)2.75308422
94regulation of platelet aggregation (GO:0090330)2.74697676
95startle response (GO:0001964)2.74182219
96regulation of DNA endoreduplication (GO:0032875)2.74147157
97protein polyglutamylation (GO:0018095)2.73437217
98photoreceptor cell maintenance (GO:0045494)2.73360222
99dendritic cell chemotaxis (GO:0002407)2.73290627
100female gonad development (GO:0008585)2.73265939
101negative regulation of keratinocyte proliferation (GO:0010839)2.73158758
102opioid receptor signaling pathway (GO:0038003)2.72853300
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.71734550
104presynaptic membrane assembly (GO:0097105)2.71564501
105DNA deamination (GO:0045006)2.71493312
106positive regulation of defense response to virus by host (GO:0002230)2.71072383
107detection of molecule of bacterial origin (GO:0032490)2.69548951
108piRNA metabolic process (GO:0034587)2.68006729
109regulation of activation of Janus kinase activity (GO:0010533)2.66617544
110positive regulation of mast cell activation involved in immune response (GO:0033008)2.66315050
111positive regulation of mast cell degranulation (GO:0043306)2.66315050
112auditory receptor cell stereocilium organization (GO:0060088)2.65510540
113granulocyte activation (GO:0036230)2.64808594
114dendritic cell migration (GO:0036336)2.64585800
115antigen processing and presentation of endogenous antigen (GO:0019883)2.63345902
116microtubule-based movement (GO:0007018)2.63311495
117righting reflex (GO:0060013)2.61393876
118response to peptidoglycan (GO:0032494)2.61197591
119reactive oxygen species biosynthetic process (GO:1903409)2.61144424
120lateral ventricle development (GO:0021670)2.60432335
121response to host (GO:0075136)2.60324470
122response to host defenses (GO:0052200)2.60324470
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60324470
124rRNA catabolic process (GO:0016075)2.59732709
125negative regulation of lymphocyte mediated immunity (GO:0002707)2.59440708
126sperm motility (GO:0030317)2.59146171
127cellular response to interferon-beta (GO:0035458)2.58526255
128germinal center formation (GO:0002467)2.58518032
129regulation of germinal center formation (GO:0002634)2.56373212
130cellular response to interleukin-15 (GO:0071350)2.56227238
131positive regulation of interleukin-1 secretion (GO:0050716)2.56086350
132termination of G-protein coupled receptor signaling pathway (GO:0038032)2.54661558
133positive regulation of uterine smooth muscle contraction (GO:0070474)2.54050382
134negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53218974
135drug catabolic process (GO:0042737)2.51371699
136presynaptic membrane organization (GO:0097090)2.51125767
137androgen biosynthetic process (GO:0006702)2.51048709
138positive regulation of oligodendrocyte differentiation (GO:0048714)2.50961997
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50511826
140keratinocyte development (GO:0003334)2.50162772
141regulation of pigment cell differentiation (GO:0050932)2.49786835
142dentate gyrus development (GO:0021542)2.48585526
143respiratory burst (GO:0045730)2.48381447
144retinoic acid metabolic process (GO:0042573)2.47875116
145phosphatidylcholine biosynthetic process (GO:0006656)2.47692494
146positive regulation of antigen processing and presentation (GO:0002579)2.47372294
147negative regulation of granulocyte differentiation (GO:0030853)2.47290377
148phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46983215
149regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.46928045
150lymphoid progenitor cell differentiation (GO:0002320)2.45756488
151negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.44900425
152developmental pigmentation (GO:0048066)2.44535064
153nucleoside diphosphate phosphorylation (GO:0006165)2.42622686
154regulation of gamma-delta T cell differentiation (GO:0045586)2.42269930
155regulation of mast cell activation (GO:0033003)2.41774360
156regulation of male gonad development (GO:2000018)2.41411132
157cell differentiation involved in metanephros development (GO:0072202)2.41255189
158negative regulation of osteoblast proliferation (GO:0033689)2.41210260
159superoxide metabolic process (GO:0006801)2.40946009
160regulation of interleukin-1 beta secretion (GO:0050706)2.40769001
161detection of external biotic stimulus (GO:0098581)2.40209296
162positive regulation of B cell proliferation (GO:0030890)2.39787106
163O-glycan processing (GO:0016266)2.39015720
164regulation of antigen processing and presentation (GO:0002577)2.38012352
165cellular response to exogenous dsRNA (GO:0071360)2.37152727
166B cell activation (GO:0042113)2.36498446
167neutrophil activation involved in immune response (GO:0002283)2.36401729
168regulation of alpha-beta T cell proliferation (GO:0046640)2.36174050
169negative regulation of homotypic cell-cell adhesion (GO:0034111)2.36163205
170regulation of interferon-alpha production (GO:0032647)2.35713165
171regulation of timing of cell differentiation (GO:0048505)2.35522419
172termination of signal transduction (GO:0023021)2.34961858
173benzene-containing compound metabolic process (GO:0042537)2.34371368
174determination of left/right symmetry (GO:0007368)2.33501734
175reflex (GO:0060004)2.33279523
176T cell lineage commitment (GO:0002360)2.32151969
177lipopolysaccharide metabolic process (GO:0008653)2.30861748
178cAMP catabolic process (GO:0006198)2.30769868
179organic cation transport (GO:0015695)2.30533389
180drinking behavior (GO:0042756)2.30437271
181regulation of interleukin-13 production (GO:0032656)2.30058476
182regulation of gamma-delta T cell activation (GO:0046643)2.27796667
183thyroid hormone metabolic process (GO:0042403)2.27373603
184negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.26510641
185glutathione derivative biosynthetic process (GO:1901687)2.25647194
186glutathione derivative metabolic process (GO:1901685)2.25647194
187sulfate transmembrane transport (GO:1902358)2.25418948
188positive regulation of meiosis (GO:0045836)2.23910235
189lateral sprouting from an epithelium (GO:0060601)2.22890355
190axonemal dynein complex assembly (GO:0070286)13.5634143
191cilium or flagellum-dependent cell motility (GO:0001539)12.8913663
192cilium movement (GO:0003341)11.0510257
193epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.7267285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.68085894
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65911126
3PCGF2_27294783_Chip-Seq_ESCs_Mouse2.87244943
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.73932077
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70068177
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.69265360
7SUZ12_27294783_Chip-Seq_NPCs_Mouse2.52093403
8NFE2_27457419_Chip-Seq_LIVER_Mouse2.51203917
9PCGF2_27294783_Chip-Seq_NPCs_Mouse2.49221021
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46638548
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34275999
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.29311613
13AR_21572438_ChIP-Seq_LNCaP_Human2.26273590
14EZH2_22144423_ChIP-Seq_EOC_Human2.25474047
15* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16946981
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15410386
17EZH2_27294783_Chip-Seq_NPCs_Mouse2.10761481
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08803377
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06465762
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04846801
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04830779
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98249155
23STAT3_18555785_Chip-Seq_ESCs_Mouse1.93012295
24EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.92281551
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.92128933
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91199912
27P53_22387025_ChIP-Seq_ESCs_Mouse1.90888232
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90074753
29DROSHA_22980978_ChIP-Seq_HELA_Human1.90030388
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.89076551
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.88555651
32ZNF274_21170338_ChIP-Seq_K562_Hela1.85073545
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.83341701
34NMYC_18555785_Chip-Seq_ESCs_Mouse1.80902651
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.79605017
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77978973
37EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.74908877
38TAF15_26573619_Chip-Seq_HEK293_Human1.74240067
39P300_19829295_ChIP-Seq_ESCs_Human1.73800065
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.73451108
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.72413356
42RUNX1_27457419_Chip-Seq_LIVER_Mouse1.71678183
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71240691
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70713390
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68299757
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66050191
47P300_18555785_Chip-Seq_ESCs_Mouse1.64372162
48PU1_27457419_Chip-Seq_LIVER_Mouse1.63761207
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.61106479
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60705681
51SOX2_18555785_Chip-Seq_ESCs_Mouse1.58860849
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57371071
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.56799774
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55129728
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53753860
56IGF1R_20145208_ChIP-Seq_DFB_Human1.53603536
57ESRRB_18555785_Chip-Seq_ESCs_Mouse1.53253635
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52380032
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.51749121
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51158464
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.50848992
62OCT4_21477851_ChIP-Seq_ESCs_Mouse1.50617314
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50092681
64BCAT_22108803_ChIP-Seq_LS180_Human1.49931516
65KLF4_18555785_Chip-Seq_ESCs_Mouse1.48529148
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48517510
67SMRT_27268052_Chip-Seq_Bcells_Human1.47826120
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45972089
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45892371
70SMAD1_18555785_Chip-Seq_ESCs_Mouse1.45833356
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.45518375
72RNF2_27304074_Chip-Seq_NSC_Mouse1.45282210
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.43163044
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.42804751
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36488020
76RUNX_20019798_ChIP-Seq_JUKART_Human1.35813096
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35680497
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35576813
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.35324918
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34507185
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.33358367
82ER_23166858_ChIP-Seq_MCF-7_Human1.32790452
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32504348
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32262414
85SMAD4_21799915_ChIP-Seq_A2780_Human1.31997299
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.31423834
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31067820
88SOX2_19829295_ChIP-Seq_ESCs_Human1.30407197
89NANOG_19829295_ChIP-Seq_ESCs_Human1.30407197
90FUS_26573619_Chip-Seq_HEK293_Human1.29002896
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28987868
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.27397863
93* FOXA1_25329375_ChIP-Seq_VCAP_Human1.26908508
94* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26908508
95TP53_18474530_ChIP-ChIP_U2OS_Human1.26166261
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26165234
97AHR_22903824_ChIP-Seq_MCF-7_Human1.25080083
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24497714
99* KDM2B_26808549_Chip-Seq_REH_Human1.23769356
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23641006
101STAT1_20625510_ChIP-Seq_HELA_Human1.23006368
102EWS_26573619_Chip-Seq_HEK293_Human1.22660128
103CBP_20019798_ChIP-Seq_JUKART_Human1.22524674
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22524674
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22482755
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22204443
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.21738515
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20419133
109VDR_22108803_ChIP-Seq_LS180_Human1.19592756
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19563999
111TCF4_22108803_ChIP-Seq_LS180_Human1.18695490
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17398835
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17398835
114TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16868850
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15803232
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14794539
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14350620
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13804737
119NCOR_22424771_ChIP-Seq_293T_Human1.13269864
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11836060
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11684766
122STAT3_23295773_ChIP-Seq_U87_Human1.11612989
123RNF2_27304074_Chip-Seq_ESCs_Mouse1.11358186
124TP63_23658742_ChIP-Seq_EP156T_Human1.11322015
125ETV1_20927104_ChIP-Seq_GIST48_Human1.10108039
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09885143
127EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09592519
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09421257
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09009052
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.08666376
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.08397335
132TCF4_23295773_ChIP-Seq_U87_Human1.08247546
133AR_25329375_ChIP-Seq_VCAP_Human1.08175180
134EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08006824
135RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08006824
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.06868774
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06844671
138GATA3_27048872_Chip-Seq_THYMUS_Human1.06839946
139* GATA3_26560356_Chip-Seq_TH2_Human1.06771837
140NOTCH1_21737748_ChIP-Seq_TLL_Human1.05577789
141* GATA3_21878914_ChIP-Seq_MCF-7_Human1.04974153
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04300759
143RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04181807
144* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04099347
145IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04062794
146CDX2_22108803_ChIP-Seq_LS180_Human1.03072498
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02961228
148PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02911154
149TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02224160
150AR_20517297_ChIP-Seq_VCAP_Human1.01278682
151TP53_16413492_ChIP-PET_HCT116_Human0.99901044
152HOXB7_26014856_ChIP-Seq_BT474_Human0.99319529
153FLI1_21867929_ChIP-Seq_TH2_Mouse0.96169779
154RUNX2_22187159_ChIP-Seq_PCA_Human0.95961525
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.95313527
156PHF8_20622853_ChIP-Seq_HELA_Human0.94737865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.24766619
2MP0002837_dystrophic_cardiac_calcinosis4.60870706
3MP0001188_hyperpigmentation4.41442004
4MP0001835_abnormal_antigen_presentation3.41651398
5MP0008875_abnormal_xenobiotic_pharmacok3.40108832
6MP0006292_abnormal_olfactory_placode3.13829881
7MP0000569_abnormal_digit_pigmentation2.73140880
8MP0002102_abnormal_ear_morphology2.57206690
9MP0003646_muscle_fatigue2.51728527
10MP0000015_abnormal_ear_pigmentation2.47342089
11MP0004043_abnormal_pH_regulation2.45859855
12* MP0001790_abnormal_immune_system2.44792343
13* MP0005387_immune_system_phenotype2.44792343
14MP0002277_abnormal_respiratory_mucosa2.39398514
15MP0000566_synostosis2.36847374
16MP0005174_abnormal_tail_pigmentation2.32835074
17MP0003787_abnormal_imprinting2.27422450
18MP0005671_abnormal_response_to2.26862833
19* MP0001800_abnormal_humoral_immune2.26340332
20MP0005645_abnormal_hypothalamus_physiol2.26327269
21MP0003045_fibrosis2.17657625
22MP0003195_calcinosis2.15318856
23MP0002160_abnormal_reproductive_system2.10949708
24MP0003136_yellow_coat_color2.04231269
25MP0002148_abnormal_hypersensitivity_rea1.97588483
26* MP0002452_abnormal_antigen_presenting1.92894906
27MP0008058_abnormal_DNA_repair1.84939749
28MP0001986_abnormal_taste_sensitivity1.79571085
29MP0010386_abnormal_urinary_bladder1.79160702
30MP0009785_altered_susceptibility_to1.76984430
31* MP0002723_abnormal_immune_serum1.73725928
32MP0005646_abnormal_pituitary_gland1.69823818
33* MP0005000_abnormal_immune_tolerance1.66420261
34MP0002876_abnormal_thyroid_physiology1.64792624
35MP0004381_abnormal_hair_follicle1.62405459
36MP0004742_abnormal_vestibular_system1.60705029
37MP0005409_darkened_coat_color1.59033536
38MP0002168_other_aberrant_phenotype1.58690373
39* MP0002420_abnormal_adaptive_immunity1.57878408
40* MP0001819_abnormal_immune_cell1.57655217
41MP0003890_abnormal_embryonic-extraembry1.56603325
42MP0005171_absent_coat_pigmentation1.55601746
43MP0003878_abnormal_ear_physiology1.54532666
44MP0005377_hearing/vestibular/ear_phenot1.54532666
45MP0005389_reproductive_system_phenotype1.53490932
46MP0008995_early_reproductive_senescence1.52729836
47MP0004133_heterotaxia1.52649785
48MP0004782_abnormal_surfactant_physiolog1.51286501
49MP0002419_abnormal_innate_immunity1.48976929
50MP0005085_abnormal_gallbladder_physiolo1.47116435
51MP0005075_abnormal_melanosome_morpholog1.46334148
52* MP0005025_abnormal_response_to1.45896444
53MP0003183_abnormal_peptide_metabolism1.44349479
54MP0006082_CNS_inflammation1.38515008
55MP0002928_abnormal_bile_duct1.37614690
56MP0000490_abnormal_crypts_of1.36074308
57MP0008872_abnormal_physiological_respon1.31799003
58MP0002095_abnormal_skin_pigmentation1.29640535
59MP0001485_abnormal_pinna_reflex1.27572169
60MP0001502_abnormal_circadian_rhythm1.24556341
61MP0001486_abnormal_startle_reflex1.24501231
62MP0003763_abnormal_thymus_physiology1.23997488
63MP0003786_premature_aging1.22314936
64MP0003941_abnormal_skin_development1.21602322
65MP0002735_abnormal_chemical_nociception1.20835966
66MP0002736_abnormal_nociception_after1.20077688
67MP0008789_abnormal_olfactory_epithelium1.20050047
68MP0002638_abnormal_pupillary_reflex1.19473808
69MP0009764_decreased_sensitivity_to1.18890662
70MP0005379_endocrine/exocrine_gland_phen1.18059085
71* MP0000716_abnormal_immune_system1.16572689
72MP0002396_abnormal_hematopoietic_system1.14405707
73* MP0002398_abnormal_bone_marrow1.14048112
74MP0002163_abnormal_gland_morphology1.13427761
75MP0009780_abnormal_chondrocyte_physiolo1.12650667
76MP0008260_abnormal_autophagy1.11473536
77MP0000685_abnormal_immune_system1.10873697
78MP0001765_abnormal_ion_homeostasis1.10688567
79MP0000681_abnormal_thyroid_gland1.09160262
80MP0005253_abnormal_eye_physiology1.08212828
81MP0010155_abnormal_intestine_physiology1.08019424
82MP0002132_abnormal_respiratory_system1.07765369
83MP0009046_muscle_twitch1.06830248
84MP0002009_preneoplasia1.05373981
85MP0003252_abnormal_bile_duct1.04770928
86MP0001873_stomach_inflammation1.04616182
87MP0009765_abnormal_xenobiotic_induced1.04457785
88MP0002138_abnormal_hepatobiliary_system1.03361043
89MP0005451_abnormal_body_composition1.02423108
90MP0000026_abnormal_inner_ear1.02290191
91MP0005083_abnormal_biliary_tract1.02005312
92MP0000579_abnormal_nail_morphology1.01899898
93MP0001346_abnormal_lacrimal_gland1.01165413
94MP0002282_abnormal_trachea_morphology0.99363689
95MP0001968_abnormal_touch/_nociception0.98955521
96MP0002938_white_spotting0.98618476
97MP0000383_abnormal_hair_follicle0.98252954
98MP0003880_abnormal_central_pattern0.98079838
99MP0010678_abnormal_skin_adnexa0.96714497
100MP0004130_abnormal_muscle_cell0.95092071
101MP0001879_abnormal_lymphatic_vessel0.95030171
102MP0004885_abnormal_endolymph0.94448387
103* MP0000689_abnormal_spleen_morphology0.93919521
104MP0005395_other_phenotype0.93508595
105MP0009697_abnormal_copulation0.92697011
106MP0001970_abnormal_pain_threshold0.92451322
107MP0001963_abnormal_hearing_physiology0.91977405
108MP0003868_abnormal_feces_composition0.91683525
109MP0001186_pigmentation_phenotype0.91411971
110MP0005310_abnormal_salivary_gland0.91379652
111MP0002254_reproductive_system_inflammat0.90670540
112MP0003436_decreased_susceptibility_to0.90246135
113MP0005365_abnormal_bile_salt0.86037771
114MP0005551_abnormal_eye_electrophysiolog0.85630728
115MP0008877_abnormal_DNA_methylation0.85122126
116MP0004808_abnormal_hematopoietic_stem0.84097182
117MP0003866_abnormal_defecation0.83539755
118MP0000372_irregular_coat_pigmentation0.83085432
119* MP0002429_abnormal_blood_cell0.82617967
120MP0002909_abnormal_adrenal_gland0.80873223
121MP0001324_abnormal_eye_pigmentation0.79841543
122MP0000427_abnormal_hair_cycle0.79467949
123MP0000465_gastrointestinal_hemorrhage0.78877163
124MP0003879_abnormal_hair_cell0.78524122
125MP0009745_abnormal_behavioral_response0.78398133
126MP0002405_respiratory_system_inflammati0.78104260
127MP0001984_abnormal_olfaction0.78051432
128MP0000631_abnormal_neuroendocrine_gland0.77710453
129MP0002272_abnormal_nervous_system0.77252846
130MP0004883_abnormal_blood_vessel0.77138127
131* MP0001845_abnormal_inflammatory_respons0.77097215
132MP0003724_increased_susceptibility_to0.77074103
133MP0000678_abnormal_parathyroid_gland0.76035999
134MP0002734_abnormal_mechanical_nocicepti0.75047703
135MP0008004_abnormal_stomach_pH0.74651919
136MP0003656_abnormal_erythrocyte_physiolo0.74485598
137MP0005464_abnormal_platelet_physiology0.74362041
138MP0004019_abnormal_vitamin_homeostasis0.73999656
139MP0001919_abnormal_reproductive_system0.73874346
140MP0002177_abnormal_outer_ear0.73600886
141MP0005670_abnormal_white_adipose0.73551864
142MP0002006_tumorigenesis0.72368211
143MP0004142_abnormal_muscle_tone0.72097943
144MP0002067_abnormal_sensory_capabilities0.70293141
145MP0002733_abnormal_thermal_nociception0.70192711
146* MP0002722_abnormal_immune_system0.69557636
147MP0005636_abnormal_mineral_homeostasis0.69218921
148MP0004145_abnormal_muscle_electrophysio0.68931845
149MP0002229_neurodegeneration0.68800262
150MP0000470_abnormal_stomach_morphology0.68565352

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.66318335
2Abnormal respiratory motile cilium morphology (HP:0005938)9.07922395
3Abnormal respiratory epithelium morphology (HP:0012253)9.07922395
4Abnormal respiratory motile cilium physiology (HP:0012261)8.82225045
5Rhinitis (HP:0012384)7.87648236
6Bronchiectasis (HP:0002110)6.27327695
7Chronic bronchitis (HP:0004469)6.00075766
8Nasal polyposis (HP:0100582)4.86135165
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.79131544
10Pancreatic cysts (HP:0001737)4.39492634
11Pancreatic fibrosis (HP:0100732)4.35605591
12Chromsome breakage (HP:0040012)4.24913489
13Febrile seizures (HP:0002373)4.11484378
14Agammaglobulinemia (HP:0004432)4.02850011
15Abnormality of the nasal mucosa (HP:0000433)3.86722675
16Bronchitis (HP:0012387)3.80672325
17Nephronophthisis (HP:0000090)3.55236272
18Recurrent sinusitis (HP:0011108)3.43653417
19Recurrent pneumonia (HP:0006532)3.43381560
20Abnormality of midbrain morphology (HP:0002418)3.39252014
21Molar tooth sign on MRI (HP:0002419)3.39252014
22Cystic liver disease (HP:0006706)3.37074646
23Infertility (HP:0000789)3.17212484
24Recurrent otitis media (HP:0000403)3.16920574
25Prostate neoplasm (HP:0100787)3.08870275
26Abnormality of B cell number (HP:0010975)3.05435241
27B lymphocytopenia (HP:0010976)3.05435241
28Recurrent abscess formation (HP:0002722)3.01465825
29Abnormality of the renal medulla (HP:0100957)2.98162085
30Dry hair (HP:0011359)2.95673334
31Retrobulbar optic neuritis (HP:0100654)2.95253937
32Optic neuritis (HP:0100653)2.95253937
33Onycholysis (HP:0001806)2.94461480
34Eczematoid dermatitis (HP:0000976)2.84215457
35Meningitis (HP:0001287)2.84129894
36Gastrointestinal stroma tumor (HP:0100723)2.80646523
37Occipital encephalocele (HP:0002085)2.78873837
38Male infertility (HP:0003251)2.78077767
39Hypothermia (HP:0002045)2.76714242
40Clubbing of toes (HP:0100760)2.73936120
41Abnormal rod and cone electroretinograms (HP:0008323)2.73664503
42Chronic sinusitis (HP:0011109)2.72923734
43Mediastinal lymphadenopathy (HP:0100721)2.64741496
44Abnormality of DNA repair (HP:0003254)2.64330466
45Abnormality of incisor morphology (HP:0011063)2.63656778
46Obstructive lung disease (HP:0006536)2.58366998
47Chronic obstructive pulmonary disease (HP:0006510)2.58366998
48Recurrent lower respiratory tract infections (HP:0002783)2.58241966
49Chronic hepatic failure (HP:0100626)2.58184805
50Decreased circulating renin level (HP:0003351)2.55533931
51Recurrent bacterial skin infections (HP:0005406)2.54739718
52Asplenia (HP:0001746)2.54634182
53Septo-optic dysplasia (HP:0100842)2.54432968
54Tubulointerstitial nephritis (HP:0001970)2.50395736
55Congenital sensorineural hearing impairment (HP:0008527)2.45811494
56IgM deficiency (HP:0002850)2.45326290
57Furrowed tongue (HP:0000221)2.45322389
58Aplasia/Hypoplasia of the spleen (HP:0010451)2.44839491
59Postaxial foot polydactyly (HP:0001830)2.40807190
60Congenital stationary night blindness (HP:0007642)2.40465319
61Anencephaly (HP:0002323)2.36527494
62Alveolar cell carcinoma (HP:0006519)2.34693964
63Vasculitis (HP:0002633)2.34235563
64Abnormality of the preputium (HP:0100587)2.33224516
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.31831452
66Recurrent viral infections (HP:0004429)2.27099282
67Hyperactive renin-angiotensin system (HP:0000841)2.27092896
68Abnormal hair whorl (HP:0010721)2.25893710
69Hypoplasia of the fovea (HP:0007750)2.25428807
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.25428807
71Recurrent bronchitis (HP:0002837)2.22503037
72Recurrent cutaneous fungal infections (HP:0011370)2.21647405
73Chronic mucocutaneous candidiasis (HP:0002728)2.21647405
74Abnormality of the renal cortex (HP:0011035)2.20181748
75Abnormality of the renal collecting system (HP:0004742)2.20047984
76Chronic otitis media (HP:0000389)2.19212348
77Medial flaring of the eyebrow (HP:0010747)2.18615782
78Male pseudohermaphroditism (HP:0000037)2.17848265
79True hermaphroditism (HP:0010459)2.16954116
80Inflammation of the large intestine (HP:0002037)2.16349906
81Patchy hypopigmentation of hair (HP:0011365)2.16143924
82Recurrent fungal infections (HP:0002841)2.15829976
83Tubular atrophy (HP:0000092)2.15623303
84Conical tooth (HP:0000698)2.14218341
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.13417039
86Abnormality of the prostate (HP:0008775)2.12867130
87Decreased central vision (HP:0007663)2.12426090
88White forelock (HP:0002211)2.10532378
89Gingivitis (HP:0000230)2.09315243
90Colitis (HP:0002583)2.08626026
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.08541830
92Orchitis (HP:0100796)2.08056899
93Myositis (HP:0100614)2.07785904
94Duplicated collecting system (HP:0000081)2.05619426
95Upper limb muscle weakness (HP:0003484)2.05452538
96Chronic diarrhea (HP:0002028)2.04117552
97Distal lower limb muscle weakness (HP:0009053)2.04106489
98Renal cortical cysts (HP:0000803)2.03777976
99Abnormality of chromosome stability (HP:0003220)2.03669974
100Meckel diverticulum (HP:0002245)2.03624504
101Cellulitis (HP:0100658)2.03561284
102Sclerocornea (HP:0000647)2.01573814
103Abnormality of the ileum (HP:0001549)2.00201470
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.00120623
105Absent/shortened dynein arms (HP:0200106)2.00120623
106Optic nerve hypoplasia (HP:0000609)1.98768506
107Neoplasm of the tracheobronchial system (HP:0100552)1.98302054
108Amelogenesis imperfecta (HP:0000705)1.97067462
109Lymphopenia (HP:0001888)1.96981192
110Osteomyelitis (HP:0002754)1.95224522
111Protruding tongue (HP:0010808)1.94939286
112Fair hair (HP:0002286)1.94721025
113Lip pit (HP:0100267)1.91975117
114Focal motor seizures (HP:0011153)1.86875635
115Microvesicular hepatic steatosis (HP:0001414)1.86621417
116Abnormal ciliary motility (HP:0012262)1.86333800
117IgG deficiency (HP:0004315)1.85864579
118Abolished electroretinogram (ERG) (HP:0000550)1.85796989
119Conjugated hyperbilirubinemia (HP:0002908)1.82987254
120Leukopenia (HP:0001882)1.82870019
121Distal lower limb amyotrophy (HP:0008944)1.82474540
122Cheilitis (HP:0100825)1.81852714
123Ectopic kidney (HP:0000086)1.78525368
124Congenital hepatic fibrosis (HP:0002612)1.78133051
125Thyroid-stimulating hormone excess (HP:0002925)1.78034346
126Hip dysplasia (HP:0001385)1.77836301
127Osteomalacia (HP:0002749)1.77665909
128Gastrointestinal inflammation (HP:0004386)1.76748642
129Elevated erythrocyte sedimentation rate (HP:0003565)1.76548172
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.75562848
131Ectropion (HP:0000656)1.75026636
132Abnormal drinking behavior (HP:0030082)1.74379257
133Polydipsia (HP:0001959)1.74379257
134Keratitis (HP:0000491)1.73805100
135Prolonged bleeding time (HP:0003010)1.73420079
136Congenital primary aphakia (HP:0007707)1.72551017
137Type I transferrin isoform profile (HP:0003642)1.72443857
138Bony spicule pigmentary retinopathy (HP:0007737)1.72167110
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72166069
140Recurrent gram-negative bacterial infections (HP:0005420)1.71965787
141Median cleft lip (HP:0000161)1.71200880
142Panhypogammaglobulinemia (HP:0003139)1.71099505
143Hyperkalemia (HP:0002153)1.68435406
144Gait imbalance (HP:0002141)1.68187065
145Stomatitis (HP:0010280)1.67936830
146Nephrogenic diabetes insipidus (HP:0009806)1.64276373
147Severe visual impairment (HP:0001141)1.63056374
148Pendular nystagmus (HP:0012043)1.62730607
149Nephropathy (HP:0000112)1.62252536
150Retinitis pigmentosa (HP:0000510)1.60963356
151Oculomotor apraxia (HP:0000657)1.57514899
152Abnormality of renin-angiotensin system (HP:0000847)1.55955341
153Atelectasis (HP:0100750)1.55102384
154Abnormal biliary tract physiology (HP:0012439)1.49746911
155Bile duct proliferation (HP:0001408)1.49746911
156Abnormality of macular pigmentation (HP:0008002)1.48461101
157Postaxial hand polydactyly (HP:0001162)1.47513451
158Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.46193972
159Genetic anticipation (HP:0003743)1.45267925
160Constricted visual fields (HP:0001133)1.45254583
161Renal salt wasting (HP:0000127)1.44893534
162Tubulointerstitial abnormality (HP:0001969)1.41152292
163Hyperaldosteronism (HP:0000859)1.39959122
164Carpal bone hypoplasia (HP:0001498)1.38072657
165Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.36131461
166Macular degeneration (HP:0000608)1.35917770
167Gaze-evoked nystagmus (HP:0000640)1.35747066
168Genital tract atresia (HP:0001827)1.35514854
169Hypokalemic alkalosis (HP:0001949)1.34116598
170Portal hypertension (HP:0001409)1.33820994
171Vaginal atresia (HP:0000148)1.32577587
172Stage 5 chronic kidney disease (HP:0003774)1.29525433
173Preaxial hand polydactyly (HP:0001177)1.29407149
174Agitation (HP:0000713)1.28534276
175Ventricular fibrillation (HP:0001663)1.27862183
176Abnormality of the hepatic vasculature (HP:0006707)1.25743746
177Acanthocytosis (HP:0001927)1.24656786
178Increased corneal curvature (HP:0100692)1.24649716
179Keratoconus (HP:0000563)1.24649716
180Attenuation of retinal blood vessels (HP:0007843)1.24486060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.13872075
2LATS14.50022380
3IRAK34.04216138
4MAP3K143.40179829
5ACVR1B2.59576205
6TXK2.55966816
7IRAK42.55481735
8PRPF4B2.42328933
9TNIK2.29428788
10SIK32.22517059
11EIF2AK22.16437915
12STK161.99656982
13STK381.98425825
14GRK11.97235225
15ZAK1.96491989
16YES11.82113612
17MAP4K11.80407703
18CSK1.79878694
19MAP3K131.76283743
20MAP3K21.75146133
21GRK61.68452108
22INSRR1.63769395
23PTK2B1.62065873
24SGK21.61050690
25IKBKB1.53772418
26AKT31.53551313
27ADRBK21.46568044
28TEC1.44941610
29MAPKAPK31.44264036
30MAP4K21.43525395
31RIPK41.42796444
32PINK11.40719532
33BMPR21.36999864
34IKBKE1.36802900
35BLK1.31178747
36JAK11.29510310
37CDK31.28098413
38TNK21.21940303
39MAP2K71.20984506
40LATS21.19709026
41MKNK21.16060022
42CHUK1.15632139
43MAPK131.15369794
44MAP2K21.15044958
45NME11.14502615
46STK101.13547920
47TYK21.10232186
48OXSR11.09557194
49ADRBK11.09036420
50NLK1.08132940
51NEK61.07070747
52SYK1.05252520
53JAK31.04290393
54BRD41.02859768
55ITK1.01449498
56NTRK31.01176937
57BTK0.97992776
58EPHA30.97870189
59WNK30.95724666
60ERBB30.94771216
61IRAK10.94359906
62MUSK0.93536747
63GRK70.92797613
64TAOK20.90463135
65LYN0.89459261
66CLK10.88994451
67STK30.87961200
68KIT0.84815306
69MAPK70.84768188
70STK110.84425538
71MST40.83422294
72MELK0.82925513
73TIE10.82010153
74PRKCE0.81226088
75CDK80.78629211
76HCK0.78570376
77SGK30.77887427
78PKN10.77616557
79MAP3K70.76626424
80SGK4940.75986645
81SGK2230.75986645
82CSF1R0.74982163
83NUAK10.74574942
84CDK90.73735544
85IRAK20.71524224
86DAPK20.69200997
87ERBB20.67921028
88TRIM280.67535380
89TBK10.67268717
90PRKD20.66557180
91SIK20.66543299
92EIF2AK30.65575124
93PRKD30.64878701
94PDPK10.64188619
95FER0.63845329
96SRPK10.63800161
97GRK50.62762235
98TAOK30.61918582
99MKNK10.61583941
100BMPR1B0.61424306
101SGK10.60364632
102PRKCI0.60083479
103FES0.59585545
104NTRK20.59256889
105HIPK20.57906251
106MAP3K30.57405289
107STK38L0.56883878
108PLK40.56601801
109LCK0.55348508
110VRK10.54274392
111CAMKK20.52873882
112EPHA20.52721571
113PIM10.50301881
114MATK0.49133637
115PIK3CG0.49089529
116MAP2K10.49002182
117ATR0.47793879
118STK240.47703563
119PRKCQ0.47525576
120STK390.46551902
121PRKD10.45475999
122CAMK1G0.44754961
123CAMK10.43012929
124ABL10.42787664
125PAK30.41806807
126CDC42BPA0.41482282
127TLK10.41453676
128PRKCD0.40794655
129ZAP700.40279605
130WNK40.40147074
131PLK20.40113259
132PDK10.39318161
133TRPM70.38419777
134MARK30.38374053
135JAK20.38020785
136CSNK1A1L0.37088530
137TAOK10.37019760
138CCNB10.36720826
139PRKACA0.35744031
140MAP3K120.35391992
141MAPK150.35035767
142DYRK1A0.34911325
143PRKAA20.34657733
144MAP3K40.33832558
145CAMK1D0.33154214
146PRKG10.30916774
147CAMK40.30719020
148BCR0.30125100
149TAF10.29970823
150MARK20.29958270
151FRK0.29785620
152RPS6KA50.29012178
153PRKCH0.26014640

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003403.18245941
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.05417406
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.00917667
4Chemical carcinogenesis_Homo sapiens_hsa052042.96432093
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.93012362
6Primary immunodeficiency_Homo sapiens_hsa053402.47648003
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.41229435
8Graft-versus-host disease_Homo sapiens_hsa053322.15558012
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15190184
10Fanconi anemia pathway_Homo sapiens_hsa034602.14555690
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14070399
12Linoleic acid metabolism_Homo sapiens_hsa005912.10817594
13Phenylalanine metabolism_Homo sapiens_hsa003601.98422048
14* Hematopoietic cell lineage_Homo sapiens_hsa046401.98077231
15Autoimmune thyroid disease_Homo sapiens_hsa053201.88664624
16Nicotine addiction_Homo sapiens_hsa050331.88317052
17Caffeine metabolism_Homo sapiens_hsa002321.85994755
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84916659
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77987641
20Measles_Homo sapiens_hsa051621.76533763
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75990870
22Non-homologous end-joining_Homo sapiens_hsa034501.75718850
23Retinol metabolism_Homo sapiens_hsa008301.72390975
24Rheumatoid arthritis_Homo sapiens_hsa053231.69426843
25Allograft rejection_Homo sapiens_hsa053301.68371642
26Asthma_Homo sapiens_hsa053101.57748569
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56679614
28B cell receptor signaling pathway_Homo sapiens_hsa046621.54058764
29Homologous recombination_Homo sapiens_hsa034401.53300139
30beta-Alanine metabolism_Homo sapiens_hsa004101.52859267
31Tyrosine metabolism_Homo sapiens_hsa003501.50668515
32Leishmaniasis_Homo sapiens_hsa051401.47262216
33Other glycan degradation_Homo sapiens_hsa005111.44558301
34* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43605276
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43596838
36Huntingtons disease_Homo sapiens_hsa050161.41802056
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39573291
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35795600
39Herpes simplex infection_Homo sapiens_hsa051681.34616667
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34265183
41Dorso-ventral axis formation_Homo sapiens_hsa043201.33906789
42Morphine addiction_Homo sapiens_hsa050321.31870088
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30574295
44Collecting duct acid secretion_Homo sapiens_hsa049661.28536789
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28326476
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28271647
47Sphingolipid metabolism_Homo sapiens_hsa006001.22113044
48Protein export_Homo sapiens_hsa030601.21685422
49Osteoclast differentiation_Homo sapiens_hsa043801.20355579
50Influenza A_Homo sapiens_hsa051641.19869489
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18765448
52Nitrogen metabolism_Homo sapiens_hsa009101.18694359
53Taste transduction_Homo sapiens_hsa047421.17265776
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12171588
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10864451
56Phototransduction_Homo sapiens_hsa047441.07711373
57Malaria_Homo sapiens_hsa051441.06404405
58African trypanosomiasis_Homo sapiens_hsa051431.03230033
59Tryptophan metabolism_Homo sapiens_hsa003801.02065900
60Glycerolipid metabolism_Homo sapiens_hsa005611.00863966
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.97069708
62Tuberculosis_Homo sapiens_hsa051520.95317686
63Regulation of autophagy_Homo sapiens_hsa041400.95195043
64Chemokine signaling pathway_Homo sapiens_hsa040620.93951542
65TNF signaling pathway_Homo sapiens_hsa046680.92200801
66* Jak-STAT signaling pathway_Homo sapiens_hsa046300.91430771
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91382524
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87211473
69Butanoate metabolism_Homo sapiens_hsa006500.86526625
70Phagosome_Homo sapiens_hsa041450.86258709
71Type I diabetes mellitus_Homo sapiens_hsa049400.84320175
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84281746
73Peroxisome_Homo sapiens_hsa041460.84212317
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.82913065
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82645475
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81307800
77T cell receptor signaling pathway_Homo sapiens_hsa046600.81053866
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.80103577
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79752347
80Serotonergic synapse_Homo sapiens_hsa047260.79581573
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79528066
82ABC transporters_Homo sapiens_hsa020100.77554685
83Calcium signaling pathway_Homo sapiens_hsa040200.76309169
84Starch and sucrose metabolism_Homo sapiens_hsa005000.76005316
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75416539
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75333810
87Ether lipid metabolism_Homo sapiens_hsa005650.75265055
88Glutathione metabolism_Homo sapiens_hsa004800.73341767
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.72417351
90Olfactory transduction_Homo sapiens_hsa047400.72280601
91Hepatitis C_Homo sapiens_hsa051600.71766126
92Inositol phosphate metabolism_Homo sapiens_hsa005620.70829959
93Vitamin digestion and absorption_Homo sapiens_hsa049770.68876649
94Vibrio cholerae infection_Homo sapiens_hsa051100.68164593
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65571123
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65411162
97Antigen processing and presentation_Homo sapiens_hsa046120.65355891
98Basal transcription factors_Homo sapiens_hsa030220.64768148
99Hepatitis B_Homo sapiens_hsa051610.63954668
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62885002
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61741163
102N-Glycan biosynthesis_Homo sapiens_hsa005100.59478589
103Insulin secretion_Homo sapiens_hsa049110.57783590
104Legionellosis_Homo sapiens_hsa051340.57620489
105Ovarian steroidogenesis_Homo sapiens_hsa049130.53200495
106Fatty acid degradation_Homo sapiens_hsa000710.51832123
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.51401018
108Circadian entrainment_Homo sapiens_hsa047130.50881569
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50208761
110Arachidonic acid metabolism_Homo sapiens_hsa005900.50196328
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.49660540
112Glutamatergic synapse_Homo sapiens_hsa047240.49371862
113Epstein-Barr virus infection_Homo sapiens_hsa051690.48774434
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47902244
115Staphylococcus aureus infection_Homo sapiens_hsa051500.47791168
116Sulfur metabolism_Homo sapiens_hsa009200.47749308
117Pertussis_Homo sapiens_hsa051330.47700850
118Circadian rhythm_Homo sapiens_hsa047100.47644028
119Basal cell carcinoma_Homo sapiens_hsa052170.47469595
120cAMP signaling pathway_Homo sapiens_hsa040240.47154154
121Nucleotide excision repair_Homo sapiens_hsa034200.46914649
122Toxoplasmosis_Homo sapiens_hsa051450.46652900
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.45963396
124Synaptic vesicle cycle_Homo sapiens_hsa047210.42800786
125Mismatch repair_Homo sapiens_hsa034300.42228643
126Base excision repair_Homo sapiens_hsa034100.42057338
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39910203
128Apoptosis_Homo sapiens_hsa042100.36814978
129Viral myocarditis_Homo sapiens_hsa054160.35934084
130Prostate cancer_Homo sapiens_hsa052150.34571179
131Salivary secretion_Homo sapiens_hsa049700.34325900
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33912465
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33710612
134GABAergic synapse_Homo sapiens_hsa047270.33358597
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33027933
136Gastric acid secretion_Homo sapiens_hsa049710.32911779
137Pancreatic secretion_Homo sapiens_hsa049720.32759376
138Cocaine addiction_Homo sapiens_hsa050300.32469885
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30227597
140MAPK signaling pathway_Homo sapiens_hsa040100.30183618

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