IL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.08841231
2regulation of activation of Janus kinase activity (GO:0010533)5.99780422
3regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.50042875
4regulation of chronic inflammatory response (GO:0002676)5.45304309
5regulation of cytokine secretion involved in immune response (GO:0002739)4.91785262
6positive regulation of chemokine biosynthetic process (GO:0045080)4.79065432
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78702599
8neutrophil activation involved in immune response (GO:0002283)4.56279024
9T-helper 1 type immune response (GO:0042088)4.55114980
10lipopolysaccharide-mediated signaling pathway (GO:0031663)4.55050506
11regulation of podosome assembly (GO:0071801)4.53599856
12positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.50913175
13hydrogen peroxide biosynthetic process (GO:0050665)4.47709061
14regulation of RIG-I signaling pathway (GO:0039535)4.47657926
15negative regulation of interleukin-12 production (GO:0032695)4.46656092
16type I interferon signaling pathway (GO:0060337)4.42920259
17cellular response to type I interferon (GO:0071357)4.42920259
18* response to peptidoglycan (GO:0032494)4.42478896
19response to interferon-beta (GO:0035456)4.36267727
20response to type I interferon (GO:0034340)4.36227997
21regulation of membrane protein ectodomain proteolysis (GO:0051043)4.35017151
22positive regulation of heat generation (GO:0031652)4.33088049
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.31525457
24regulation of fever generation (GO:0031620)4.26663945
25positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.22044817
26cellular response to interferon-alpha (GO:0035457)4.21505978
27positive regulation of interleukin-17 production (GO:0032740)4.15017887
28positive regulation of interferon-alpha production (GO:0032727)4.13276765
29regulation of heat generation (GO:0031650)4.09357738
30superoxide anion generation (GO:0042554)4.08679581
31natural killer cell activation involved in immune response (GO:0002323)4.03988110
32negative regulation of viral genome replication (GO:0045071)4.02714303
33cellular response to interferon-beta (GO:0035458)3.94481917
34reactive oxygen species biosynthetic process (GO:1903409)3.93961300
35branching involved in labyrinthine layer morphogenesis (GO:0060670)3.93387971
36regulation of memory T cell differentiation (GO:0043380)3.92338685
37regulation of interferon-alpha production (GO:0032647)3.88433091
38granulocyte activation (GO:0036230)3.82409903
39negative regulation of nitric oxide biosynthetic process (GO:0045019)3.81437261
40* positive regulation of nitric oxide biosynthetic process (GO:0045429)3.80322705
41response to interferon-alpha (GO:0035455)3.80222525
42activation of MAPKKK activity (GO:0000185)3.79480416
43modulation by symbiont of host defense response (GO:0052031)3.79359341
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.79359341
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.79359341
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.79359341
47modulation by symbiont of host immune response (GO:0052553)3.79359341
48positive regulation by symbiont of host defense response (GO:0052509)3.79359341
49positive regulation of p38MAPK cascade (GO:1900745)3.79135833
50* regulation of nitric oxide biosynthetic process (GO:0045428)3.78896265
51regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.78210945
52negative regulation of interleukin-17 production (GO:0032700)3.77882681
53positive regulation of cellular amide metabolic process (GO:0034250)3.72483650
54* regulation of chemokine biosynthetic process (GO:0045073)3.69764975
55regulation of T-helper 1 cell differentiation (GO:0045625)3.67084709
56positive regulation of interleukin-12 production (GO:0032735)3.66259918
57positive regulation of alpha-beta T cell proliferation (GO:0046641)3.61537600
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.60889971
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54249868
60negative regulation of cytokine production involved in immune response (GO:0002719)3.48606997
61neutrophil activation (GO:0042119)3.48406962
62regulation of interleukin-17 production (GO:0032660)3.47356460
63NIK/NF-kappaB signaling (GO:0038061)3.45793634
64regulation of vitamin D biosynthetic process (GO:0060556)3.45268075
65regulation of heterotypic cell-cell adhesion (GO:0034114)3.44071150
66eosinophil chemotaxis (GO:0048245)3.43326209
67positive regulation of monocyte chemotaxis (GO:0090026)3.42200153
68positive regulation of NF-kappaB import into nucleus (GO:0042346)3.42056456
69adhesion of symbiont to host cell (GO:0044650)3.39018323
70virion attachment to host cell (GO:0019062)3.39018323
71* positive regulation of T-helper cell differentiation (GO:0045624)3.38084359
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36777413
73cellular response to nicotine (GO:0071316)3.36573753
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36166376
75respiratory burst (GO:0045730)3.36024881
76response to nitrosative stress (GO:0051409)3.34914457
77regulation of NF-kappaB import into nucleus (GO:0042345)3.34475538
78lymphocyte chemotaxis (GO:0048247)3.34222932
79* cellular response to lipopolysaccharide (GO:0071222)3.33627327
80cellular response to exogenous dsRNA (GO:0071360)3.33179416
81regulation of interleukin-8 biosynthetic process (GO:0045414)3.32363580
82immunoglobulin mediated immune response (GO:0016064)3.32331217
83regulation of alpha-beta T cell proliferation (GO:0046640)3.31138598
84positive regulation of natural killer cell differentiation (GO:0032825)3.30410079
85macrophage activation involved in immune response (GO:0002281)3.29841491
86positive regulation of response to biotic stimulus (GO:0002833)3.29521117
87positive regulation of lymphocyte migration (GO:2000403)3.28162249
88* positive regulation of acute inflammatory response (GO:0002675)3.24620854
89xenobiotic catabolic process (GO:0042178)3.24255360
90* positive regulation of type 2 immune response (GO:0002830)3.22568513
91natural killer cell mediated cytotoxicity (GO:0042267)3.22484201
92natural killer cell mediated immunity (GO:0002228)3.22484201
93detection of molecule of bacterial origin (GO:0032490)3.22185464
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.21663150
95positive regulation of defense response to virus by host (GO:0002230)3.20332740
96leukocyte aggregation (GO:0070486)3.19624520
97* cellular response to molecule of bacterial origin (GO:0071219)3.18633444
98positive regulation of transcription factor import into nucleus (GO:0042993)3.17493984
99germinal center formation (GO:0002467)3.16915946
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.13415576
101positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.12318856
102* positive regulation of interleukin-6 production (GO:0032755)3.11322227
103interferon-gamma-mediated signaling pathway (GO:0060333)3.10286768
104regulation of mononuclear cell migration (GO:0071675)3.07698814
105T cell migration (GO:0072678)3.05526791
106decidualization (GO:0046697)3.05524700
107regulation of vitamin metabolic process (GO:0030656)3.03190087
108* defense response to protozoan (GO:0042832)3.02157011
109response to muramyl dipeptide (GO:0032495)3.01737823
110eosinophil migration (GO:0072677)3.00676599
111positive regulation of cAMP-mediated signaling (GO:0043950)3.00135461
112production of molecular mediator involved in inflammatory response (GO:0002532)2.99662998
113regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.98754563
114* monocyte chemotaxis (GO:0002548)2.97857967
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.94931273
116positive regulation of T-helper 1 type immune response (GO:0002827)2.93925636
117cellular response to zinc ion (GO:0071294)2.93760329
118regulation of interferon-gamma biosynthetic process (GO:0045072)2.93454052
119positive regulation of cytokine biosynthetic process (GO:0042108)2.92699514
120negative regulation of production of molecular mediator of immune response (GO:0002701)2.91315570
121positive regulation of interferon-beta production (GO:0032728)2.91138776
122regulation of T-helper 1 type immune response (GO:0002825)2.90736905
123positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.89649835
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89491195
125myeloid dendritic cell differentiation (GO:0043011)2.89355323
126positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89298772
127response to manganese ion (GO:0010042)2.88750618
128positive regulation of T cell mediated immunity (GO:0002711)2.87432612
129regulation of interleukin-12 production (GO:0032655)2.87053092
130positive regulation vascular endothelial growth factor production (GO:0010575)2.86969348
131ovulation (GO:0030728)2.86514581
132negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.86229989
133regulation of growth of symbiont in host (GO:0044126)2.86229989
134cell adhesion mediated by integrin (GO:0033627)2.84046357
135chronic inflammatory response (GO:0002544)2.81707037
136negative regulation of growth of symbiont in host (GO:0044130)2.81414738
137modulation of growth of symbiont involved in interaction with host (GO:0044144)2.81414738
138* regulation of vascular endothelial growth factor production (GO:0010574)2.80981775
139regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.80623810
140adhesion of symbiont to host (GO:0044406)2.80075108
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79934283
142* cellular response to biotic stimulus (GO:0071216)2.77686942
143* regulation of immunoglobulin secretion (GO:0051023)2.75206207
144negative regulation of amino acid transport (GO:0051956)2.73809003
145* positive regulation of chemokine production (GO:0032722)2.70830179
146regulation of interleukin-2 biosynthetic process (GO:0045076)2.70334147
147regulation of interferon-beta biosynthetic process (GO:0045357)2.68587793
148* regulation of interleukin-6 production (GO:0032675)2.64994139
149* response to protozoan (GO:0001562)2.63885656
150positive regulation of astrocyte differentiation (GO:0048711)2.62171704
151* negative regulation of lipid storage (GO:0010888)2.62098212
152* regulation of T-helper cell differentiation (GO:0045622)2.62043769
153response to vitamin D (GO:0033280)2.58783614
154regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.57288537
155regulation of inflammatory response to antigenic stimulus (GO:0002861)2.56774015
156negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54611674
157* regulation of type 2 immune response (GO:0002828)2.54359243
158negative regulation of glucose transport (GO:0010829)2.53844141
159positive regulation of natural killer cell activation (GO:0032816)2.51339807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.75651741
2IRF8_22096565_ChIP-ChIP_GC-B_Human7.23755403
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.23575755
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.76270446
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.11916298
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.60123280
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.59853840
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58153888
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.37002041
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12938765
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.06473688
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88904958
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54474625
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39975185
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38909419
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.34776282
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.14027564
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.07199140
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.06012590
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01727427
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96493353
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96175035
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.92013085
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78118594
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57058433
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57058433
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51018796
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50201596
29* SMAD_19615063_ChIP-ChIP_OVARY_Human1.49431359
30* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48470212
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46804705
32CLOCK_20551151_ChIP-Seq_293T_Human1.44973331
33* VDR_24787735_ChIP-Seq_THP-1_Human1.41953246
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.39528669
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36839033
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35876821
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35441978
38RUNX_20019798_ChIP-Seq_JUKART_Human1.34272356
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31847836
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28020367
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28011722
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27366939
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25183408
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24672958
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23934770
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23410601
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23410601
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23410601
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.23005056
50PU_27001747_Chip-Seq_BMDM_Mouse1.21995827
51* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21941315
52SOX2_20726797_ChIP-Seq_SW620_Human1.17012685
53TP53_18474530_ChIP-ChIP_U2OS_Human1.15644876
54MYB_26560356_Chip-Seq_TH2_Human1.14641675
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11160703
56EGR1_19032775_ChIP-ChIP_M12_Human1.10805554
57* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09499717
58* BRD4_25478319_ChIP-Seq_HGPS_Human1.08872351
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07939701
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07082961
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06809095
62SPI1_23127762_ChIP-Seq_K562_Human1.04980037
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04856387
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03869140
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03683570
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.03489874
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02500627
68SPI1_23547873_ChIP-Seq_NB4_Human1.02425484
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00203853
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99907981
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98682054
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98682054
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96741144
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96712722
75TP53_16413492_ChIP-PET_HCT116_Human0.95545693
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94067390
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93629041
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92774737
79* CJUN_26792858_Chip-Seq_BT549_Human0.92360741
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91051415
81GATA1_22025678_ChIP-Seq_K562_Human0.90338397
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90324156
83GATA1_19941826_ChIP-Seq_K562_Human0.90271015
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89204544
85VDR_24763502_ChIP-Seq_THP-1_Human0.88752941
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88296260
87GATA3_26560356_Chip-Seq_TH2_Human0.87278728
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87179953
89* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87047340
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86215638
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85431817
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85197740
93EP300_21415370_ChIP-Seq_HL-1_Mouse0.80942928
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80126789
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79593011
96MYB_26560356_Chip-Seq_TH1_Human0.79491940
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77949273
98RXR_22158963_ChIP-Seq_LIVER_Mouse0.77681657
99* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76887017
100KDM2B_26808549_Chip-Seq_K562_Human0.76170202
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75138152
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75136017
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72798984
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.70656218
105VDR_22108803_ChIP-Seq_LS180_Human0.70151229
106* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69532050
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.68607543
108RUNX1_22412390_ChIP-Seq_EML_Mouse0.66333459
109* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.65815359
110GATA3_27048872_Chip-Seq_THYMUS_Human0.64934914
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64637023
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64321564
113MAF_26560356_Chip-Seq_TH1_Human0.62029251
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61384572
115PU1_27457419_Chip-Seq_LIVER_Mouse0.60098165
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59861150
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.59757561
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59190439
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58150976
120LXR_22158963_ChIP-Seq_LIVER_Mouse0.58006734
121RXR_22108803_ChIP-Seq_LS180_Human0.56484993
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.53872785
123TP63_23658742_ChIP-Seq_EP156T_Human0.53784996
124ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.52931655
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.52641050
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.52369540
127SCL_19346495_ChIP-Seq_HPC-7_Human0.52328301
128SMAD1_18555785_Chip-Seq_ESCs_Mouse0.51985316
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51758647
130NMYC_18555785_Chip-Seq_ESCs_Mouse0.50668165
131* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.49829867
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.49410790
133KLF5_25053715_ChIP-Seq_YYC3_Human0.48953011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0009785_altered_susceptibility_to4.83901300
2MP0001835_abnormal_antigen_presentation4.65506747
3MP0003724_increased_susceptibility_to4.27434395
4MP0002148_abnormal_hypersensitivity_rea4.25669094
5MP0003436_decreased_susceptibility_to3.62133843
6* MP0006082_CNS_inflammation3.45396305
7MP0005000_abnormal_immune_tolerance3.33630860
8MP0008004_abnormal_stomach_pH3.27750014
9* MP0002419_abnormal_innate_immunity3.19217062
10* MP0005025_abnormal_response_to3.11681182
11MP0009764_decreased_sensitivity_to2.70226742
12MP0003186_abnormal_redox_activity2.64580837
13MP0003303_peritoneal_inflammation2.57431096
14MP0000685_abnormal_immune_system2.50659832
15* MP0005387_immune_system_phenotype2.47150626
16* MP0001790_abnormal_immune_system2.47150626
17MP0003300_gastrointestinal_ulcer2.44977586
18* MP0002452_abnormal_antigen_presenting2.42492212
19MP0002006_tumorigenesis2.40664184
20* MP0002723_abnormal_immune_serum2.38347715
21MP0009840_abnormal_foam_cell2.34190691
22MP0008438_abnormal_cutaneous_collagen2.32865594
23MP0005671_abnormal_response_to2.24297324
24MP0005167_abnormal_blood-brain_barrier2.19090416
25MP0001800_abnormal_humoral_immune2.16424247
26MP0001853_heart_inflammation2.11477112
27MP0003075_altered_response_to2.06379662
28MP0006054_spinal_hemorrhage2.03937223
29MP0004510_myositis2.01635627
30* MP0001819_abnormal_immune_cell1.99662053
31MP0001533_abnormal_skeleton_physiology1.94925662
32* MP0002420_abnormal_adaptive_immunity1.94102493
33MP0010155_abnormal_intestine_physiology1.85694353
34MP0003448_altered_tumor_morphology1.85386210
35* MP0002332_abnormal_exercise_endurance1.83505650
36* MP0001845_abnormal_inflammatory_respons1.82676712
37MP0000858_altered_metastatic_potential1.82664456
38MP0002405_respiratory_system_inflammati1.77816158
39MP0005023_abnormal_wound_healing1.73788003
40MP0001542_abnormal_bone_strength1.72926944
41MP0005464_abnormal_platelet_physiology1.70212358
42* MP0008469_abnormal_protein_level1.69387740
43MP0003195_calcinosis1.63831728
44* MP0004947_skin_inflammation1.63683731
45MP0003950_abnormal_plasma_membrane1.59845042
46MP0000343_altered_response_to1.54285255
47MP0005451_abnormal_body_composition1.48409592
48* MP0005166_decreased_susceptibility_to1.42455856
49MP0004782_abnormal_surfactant_physiolog1.42248784
50MP0009278_abnormal_bone_marrow1.42099257
51MP0002139_abnormal_hepatobiliary_system1.39263762
52* MP0005164_abnormal_response_to1.38526047
53MP0001346_abnormal_lacrimal_gland1.34750107
54MP0002877_abnormal_melanocyte_morpholog1.32007643
55MP0004883_abnormal_blood_vessel1.30431481
56MP0002295_abnormal_pulmonary_circulatio1.30136930
57MP0005058_abnormal_lysosome_morphology1.29721376
58* MP0002998_abnormal_bone_remodeling1.28043020
59MP0001545_abnormal_hematopoietic_system1.25945702
60MP0005397_hematopoietic_system_phenotyp1.25945702
61MP0002254_reproductive_system_inflammat1.25597753
62* MP0003690_abnormal_glial_cell1.24590828
63* MP0000716_abnormal_immune_system1.24149408
64MP0005408_hypopigmentation1.21146939
65MP0003705_abnormal_hypodermis_morpholog1.19196858
66MP0003828_pulmonary_edema1.18925338
67MP0005310_abnormal_salivary_gland1.17315958
68MP0002277_abnormal_respiratory_mucosa1.16823989
69MP0005076_abnormal_cell_differentiation1.16237418
70MP0009333_abnormal_splenocyte_physiolog1.15648575
71MP0005390_skeleton_phenotype1.10777597
72MP0000569_abnormal_digit_pigmentation1.08502934
73* MP0009763_increased_sensitivity_to1.08240804
74MP0003566_abnormal_cell_adhesion1.06959711
75MP0002398_abnormal_bone_marrow1.05385279
76MP0004272_abnormal_basement_membrane1.00068872
77MP0010352_gastrointestinal_tract_polyps1.00067610
78MP0005595_abnormal_vascular_smooth0.97451133
79MP0005275_abnormal_skin_tensile0.92830049
80MP0003172_abnormal_lysosome_physiology0.91995492
81MP0005257_abnormal_intraocular_pressure0.91283061
82MP0004858_abnormal_nervous_system0.90583474
83MP0002429_abnormal_blood_cell0.89972694
84MP0003191_abnormal_cellular_cholesterol0.86036883
85MP0002090_abnormal_vision0.86002345
86MP0001851_eye_inflammation0.84403875
87MP0000249_abnormal_blood_vessel0.83484181
88MP0008874_decreased_physiological_sensi0.81742674
89MP0003646_muscle_fatigue0.76693199
90MP0000689_abnormal_spleen_morphology0.76106674
91MP0003806_abnormal_nucleotide_metabolis0.74071894
92MP0003453_abnormal_keratinocyte_physiol0.73680334
93* MP0001501_abnormal_sleep_pattern0.73476444
94MP0001958_emphysema0.73310309
95MP0000767_abnormal_smooth_muscle0.73138027
96MP0002933_joint_inflammation0.69817128
97MP0009765_abnormal_xenobiotic_induced0.69761019
98MP0002722_abnormal_immune_system0.69598776
99MP0003091_abnormal_cell_migration0.69537197
100MP0008875_abnormal_xenobiotic_pharmacok0.69292486
101MP0003763_abnormal_thymus_physiology0.69132483
102MP0002163_abnormal_gland_morphology0.69021843
103MP0003795_abnormal_bone_structure0.67850111
104MP0002132_abnormal_respiratory_system0.67793214
105MP0003656_abnormal_erythrocyte_physiolo0.67764749
106MP0003045_fibrosis0.67664593
107MP0008789_abnormal_olfactory_epithelium0.66697114
108MP0002166_altered_tumor_susceptibility0.66204410
109MP0000750_abnormal_muscle_regeneration0.65472304
110MP0001663_abnormal_digestive_system0.65341535
111MP0005171_absent_coat_pigmentation0.65236533
112MP0005379_endocrine/exocrine_gland_phen0.64283738
113MP0000371_diluted_coat_color0.64001908
114MP0005647_abnormal_sex_gland0.63044621
115MP0008873_increased_physiological_sensi0.62878856
116MP0004043_abnormal_pH_regulation0.61863954
117MP0002138_abnormal_hepatobiliary_system0.61721864
118MP0003279_aneurysm0.60322460
119MP0002136_abnormal_kidney_physiology0.59397023
120MP0000920_abnormal_myelination0.59221943
121MP0002133_abnormal_respiratory_system0.55818727
122MP0005388_respiratory_system_phenotype0.55818727
123MP0000604_amyloidosis0.55666323
124* MP0005535_abnormal_body_temperature0.54147644
125MP0005165_increased_susceptibility_to0.50427210

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.59206784
2Recurrent abscess formation (HP:0002722)6.98983901
3Recurrent bacterial skin infections (HP:0005406)6.44112085
4Recurrent gram-negative bacterial infections (HP:0005420)6.14454796
5Abnormality of glycolipid metabolism (HP:0010969)5.73076016
6Abnormality of liposaccharide metabolism (HP:0010968)5.73076016
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.73076016
8Increased IgM level (HP:0003496)5.16335407
9Elevated erythrocyte sedimentation rate (HP:0003565)4.84511631
10Prostate neoplasm (HP:0100787)4.67262337
11* Mediastinal lymphadenopathy (HP:0100721)4.67173994
12Gingivitis (HP:0000230)4.60574382
13Autoimmune thrombocytopenia (HP:0001973)4.57850326
14Abnormality of macrophages (HP:0004311)4.51293133
15Gastrointestinal infarctions (HP:0005244)4.25272189
16Stomatitis (HP:0010280)4.19372332
17Orchitis (HP:0100796)4.12615179
18Basal ganglia calcification (HP:0002135)4.11263628
19Vasculitis (HP:0002633)4.08169595
20Thick nail (HP:0001805)4.08089284
21Systemic lupus erythematosus (HP:0002725)4.07126425
22Retrobulbar optic neuritis (HP:0100654)4.00748741
23Optic neuritis (HP:0100653)4.00748741
24Nuclear cataract (HP:0100018)3.83514417
25Dysostosis multiplex (HP:0000943)3.82010279
26Loss of speech (HP:0002371)3.69359751
27Recurrent skin infections (HP:0001581)3.64861301
28Myositis (HP:0100614)3.56432330
29Periodontitis (HP:0000704)3.43356685
30Recurrent fungal infections (HP:0002841)3.34888138
31Obstructive lung disease (HP:0006536)3.31486099
32Chronic obstructive pulmonary disease (HP:0006510)3.31486099
33Urethral obstruction (HP:0000796)3.27353199
34Cellulitis (HP:0100658)3.23236347
35Disinhibition (HP:0000734)3.20240326
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.08389746
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.08389746
38Abnormality of polysaccharide metabolism (HP:0011012)3.08389746
39Osteolytic defects of the phalanges of the hand (HP:0009771)3.06721162
40Osteolytic defects of the hand bones (HP:0009699)3.06721162
41Neurofibrillary tangles (HP:0002185)3.06532352
42Pustule (HP:0200039)3.01794420
43Stomach cancer (HP:0012126)3.00067820
44Interstitial pulmonary disease (HP:0006530)2.98871533
45Hypergammaglobulinemia (HP:0010702)2.97889057
46Hematochezia (HP:0002573)2.97208919
47Mucopolysacchariduria (HP:0008155)2.96281027
48Urinary glycosaminoglycan excretion (HP:0003541)2.96281027
49Spondylolisthesis (HP:0003302)2.88406334
50Axonal loss (HP:0003447)2.81953941
51Amyloidosis (HP:0011034)2.76979348
52Autoimmune hemolytic anemia (HP:0001890)2.73283705
53Anorexia (HP:0002039)2.71923438
54Premature loss of primary teeth (HP:0006323)2.71579264
55Thoracolumbar scoliosis (HP:0002944)2.71005970
56Myocardial infarction (HP:0001658)2.69908709
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68817093
58Glomerulonephritis (HP:0000099)2.68088719
59Pulmonary infiltrates (HP:0002113)2.65831335
60Tetraparesis (HP:0002273)2.63756397
61Porencephaly (HP:0002132)2.63143796
62Recurrent viral infections (HP:0004429)2.61930447
63Premature rupture of membranes (HP:0001788)2.61029870
64Abnormality of T cell number (HP:0011839)2.58722123
65Hemoptysis (HP:0002105)2.58194413
66Recurrent pneumonia (HP:0006532)2.54925120
67Mutism (HP:0002300)2.54355890
68Urticaria (HP:0001025)2.53197906
69Protrusio acetabuli (HP:0003179)2.52846785
70Poor head control (HP:0002421)2.52546054
71Prolonged neonatal jaundice (HP:0006579)2.49746957
72Abnormality of the prostate (HP:0008775)2.46764682
73Purpura (HP:0000979)2.44449246
74Keratoconjunctivitis sicca (HP:0001097)2.43277559
75Pigmentary retinal degeneration (HP:0001146)2.38086546
76IgA deficiency (HP:0002720)2.37190428
77Lower limb hyperreflexia (HP:0002395)2.34661404
78Follicular hyperkeratosis (HP:0007502)2.31519809
79Vertebral compression fractures (HP:0002953)2.30580828
80Progressive neurologic deterioration (HP:0002344)2.30364075
81Leukocytosis (HP:0001974)2.29279053
82Increased serum ferritin (HP:0003281)2.29092801
83Gangrene (HP:0100758)2.28089532
84Thin bony cortex (HP:0002753)2.26653249
85Alveolar cell carcinoma (HP:0006519)2.26439013
86Petechiae (HP:0000967)2.25680219
87Recurrent lower respiratory tract infections (HP:0002783)2.24531378
88Meningitis (HP:0001287)2.23527645
89Keratoconjunctivitis (HP:0001096)2.23094513
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.23052868
91Peritonitis (HP:0002586)2.22180711
92Osteomyelitis (HP:0002754)2.21083977
93Apathy (HP:0000741)2.20401086
94Complement deficiency (HP:0004431)2.17904585
95Cerebral inclusion bodies (HP:0100314)2.17616254
96Asymmetric septal hypertrophy (HP:0001670)2.14853788
97Gingival bleeding (HP:0000225)2.12818023
98Vacuolated lymphocytes (HP:0001922)2.11685670
99Hepatosplenomegaly (HP:0001433)2.10103201
100T lymphocytopenia (HP:0005403)2.09358353
101Arterial thrombosis (HP:0004420)2.09098153
102Polyneuropathy (HP:0001271)2.08910282
103Recurrent cutaneous fungal infections (HP:0011370)2.08092889
104Chronic mucocutaneous candidiasis (HP:0002728)2.08092889
105Cervical subluxation (HP:0003308)2.07972040
106Malnutrition (HP:0004395)2.07803439
107Diminished motivation (HP:0000745)2.07217141
108Episodic fever (HP:0001954)2.04620223
109Hemorrhage of the eye (HP:0011885)2.03007354
110Eosinophilia (HP:0001880)2.02161001
111Chronic sinusitis (HP:0011109)2.01628487
112Increased cerebral lipofuscin (HP:0011813)2.01571982
113Segmental peripheral demyelination/remyelination (HP:0003481)2.00387422
114Skin ulcer (HP:0200042)2.00230429
115Recurrent bronchitis (HP:0002837)1.99881848
116Micronodular cirrhosis (HP:0001413)1.98687176
117Neoplasm of the tracheobronchial system (HP:0100552)1.97606011
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97407661
119Aortic dissection (HP:0002647)1.95792686
120* Abnormality of the pericardium (HP:0001697)1.94375521
121Abnormality of complement system (HP:0005339)1.93342706
122Nephritis (HP:0000123)1.92057272
123Muscle fiber splitting (HP:0003555)1.89589274
124Hypoplasia of the thymus (HP:0000778)1.89547919
125Ankle contracture (HP:0006466)1.89097477
126Aseptic necrosis (HP:0010885)1.87986770
127Metaphyseal irregularity (HP:0003025)1.86837974
128Nausea (HP:0002018)1.86785906
129Chronic otitis media (HP:0000389)1.86596662
130Zonular cataract (HP:0010920)1.86048726
131Cheilitis (HP:0100825)1.85366574
132* Arthralgia (HP:0002829)1.82412724
133Progressive visual loss (HP:0000529)1.82136724
134Glomerulopathy (HP:0100820)1.81566893
135Submucous cleft hard palate (HP:0000176)1.81168278
136Abnormality of the basal ganglia (HP:0002134)1.81004627
137Aortic aneurysm (HP:0004942)1.80887903
138Acne (HP:0001061)1.80362267
139Sepsis (HP:0100806)1.79924182
140Parakeratosis (HP:0001036)1.78067108
141Persistence of primary teeth (HP:0006335)1.77717057
142Femoral bowing (HP:0002980)1.77091619
143Emphysema (HP:0002097)1.76860523
144Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76432260
145Glucose intolerance (HP:0000833)1.76349345
146Hyperparathyroidism (HP:0000843)1.74841116
147Keratitis (HP:0000491)1.74709825
148Vertigo (HP:0002321)1.73501492
149Genu recurvatum (HP:0002816)1.72710196
150* Abnormality of the pleura (HP:0002103)1.72507295
151Flared iliac wings (HP:0002869)1.72466673
152Abnormality of T cells (HP:0002843)1.71572510
153Chest pain (HP:0100749)1.71395158
154Bone pain (HP:0002653)1.71198399
155Cleft eyelid (HP:0000625)1.70953789
156Blue sclerae (HP:0000592)1.70879017
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67231971
158Vascular tortuosity (HP:0004948)1.65463602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.73792043
2MAP3K145.02542360
3RIPK44.11990938
4IRAK33.61459375
5DDR23.31977643
6IRAK43.24604518
7JAK33.22524720
8TBK13.02132048
9TAOK23.02060974
10BMPR22.78609262
11IKBKE2.67737634
12LATS22.63757497
13IKBKB2.49051135
14MOS2.46124173
15BLK2.44218301
16NME22.38630604
17TYK22.33631868
18PIM22.16249301
19EPHA32.09524210
20EPHB12.03868570
21TXK1.95357530
22TGFBR21.95338157
23JAK11.94821502
24MST41.90728435
25PRPF4B1.87110484
26CDC42BPA1.60604841
27ERN11.59813039
28IRAK11.59541329
29TAOK11.59039300
30CHUK1.56022958
31FRK1.55062691
32PDGFRA1.43634237
33FGFR41.43030444
34BMX1.40154856
35MAP3K131.19996807
36ERBB31.16366695
37CSK1.13682311
38EIF2AK21.12742944
39MAP4K11.12538873
40NLK1.08892918
41STK41.06156095
42IRAK21.04494686
43ERBB41.04320824
44BMPR1B1.02900787
45TESK11.01813453
46ZAK1.01019317
47SYK0.99947618
48KIT0.97816458
49FGR0.95914336
50JAK20.92789390
51ARAF0.91736981
52PRKCD0.89763975
53ABL20.89212900
54HCK0.88521224
55FGFR30.88150689
56MYLK0.87019267
57MST1R0.86033486
58EPHB20.83963744
59PIM10.83312530
60MAP3K90.82329167
61PKN10.79565685
62LYN0.79293040
63BCR0.75913909
64RIPK10.75353911
65BTK0.75251333
66SIK30.74847551
67ZAP700.73342144
68NEK90.69262866
69MAP3K50.66975329
70PAK40.66489771
71ABL10.66351254
72NUAK10.64593280
73LCK0.64456889
74ADRBK20.62560952
75GRK70.61138875
76YES10.60608221
77DYRK30.58342733
78MATK0.57883829
79RPS6KA40.57129336
80MARK30.56830760
81HIPK20.56566571
82CSF1R0.55503018
83TYRO30.53777839
84MAPK40.52899141
85MAPK70.52354750
86PRKCQ0.52004194
87TEC0.49973780
88PLK20.47591657
89AKT30.47445837
90TAOK30.47025586
91TRPM70.46859327
92PRKCE0.42299286
93EGFR0.42196086
94TTN0.41079752
95MAP3K30.40790261
96PAK20.38273081
97MAP3K10.34046497
98RPS6KA50.33929334
99NEK60.33533243
100SIK10.33238074
101RPS6KA10.33023220
102PTK20.33016956
103MAP3K120.32745210
104KSR10.32502900
105MAP2K30.30905817
106LIMK10.30480688
107EIF2AK30.30252501
108CLK10.30165100
109MAPKAPK20.28345476
110MET0.27562849
111PDGFRB0.25726816
112TNK20.25215127
113STK100.24327206
114FYN0.23395181
115KSR20.23241489
116ERBB20.22506225
117DAPK20.22061689
118BRAF0.21167403
119EPHA20.20912579
120PDPK10.20416536
121MELK0.20236417
122MAP3K110.19530669
123IGF1R0.19208092
124CDK60.19105889
125STK30.18150014
126MAP3K20.17266981
127ALK0.17170669
128INSR0.16877024
129DAPK30.16457418
130GSK3A0.15859857
131ADRBK10.14855317
132MAPKAPK50.14200879

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053324.35665207
2Allograft rejection_Homo sapiens_hsa053303.86083581
3Type I diabetes mellitus_Homo sapiens_hsa049403.54408020
4Leishmaniasis_Homo sapiens_hsa051403.49691547
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046203.03792290
6* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.95460304
7* Legionellosis_Homo sapiens_hsa051342.87985036
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.67823790
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.67344557
10* Rheumatoid arthritis_Homo sapiens_hsa053232.62571086
11* Pertussis_Homo sapiens_hsa051332.48709427
12Staphylococcus aureus infection_Homo sapiens_hsa051502.45978323
13* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41313690
14* Malaria_Homo sapiens_hsa051442.34944392
15* African trypanosomiasis_Homo sapiens_hsa051432.31569193
16* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24196761
17* TNF signaling pathway_Homo sapiens_hsa046682.13265095
18Asthma_Homo sapiens_hsa053102.11796998
19* Measles_Homo sapiens_hsa051622.00127732
20* Influenza A_Homo sapiens_hsa051641.94239674
21Other glycan degradation_Homo sapiens_hsa005111.92330846
22* Tuberculosis_Homo sapiens_hsa051521.90478443
23Osteoclast differentiation_Homo sapiens_hsa043801.80598209
24* Salmonella infection_Homo sapiens_hsa051321.78249700
25Autoimmune thyroid disease_Homo sapiens_hsa053201.76490010
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68072073
27* Intestinal immune network for IgA production_Homo sapiens_hsa046721.67391539
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60878730
29Bladder cancer_Homo sapiens_hsa052191.47133504
30* Herpes simplex infection_Homo sapiens_hsa051681.44986557
31Phagosome_Homo sapiens_hsa041451.42336860
32Toxoplasmosis_Homo sapiens_hsa051451.41536617
33* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33144712
34* Hematopoietic cell lineage_Homo sapiens_hsa046401.26737078
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21801786
36Chemokine signaling pathway_Homo sapiens_hsa040621.18472440
37Apoptosis_Homo sapiens_hsa042101.14015387
38* Jak-STAT signaling pathway_Homo sapiens_hsa046301.10433597
39* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02661919
40Viral myocarditis_Homo sapiens_hsa054161.02636214
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00462624
42* Prion diseases_Homo sapiens_hsa050200.98392908
43* Amoebiasis_Homo sapiens_hsa051460.96657953
44Hepatitis C_Homo sapiens_hsa051600.89917410
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84477554
46Chemical carcinogenesis_Homo sapiens_hsa052040.81672824
47Shigellosis_Homo sapiens_hsa051310.79759096
48* Hepatitis B_Homo sapiens_hsa051610.79418940
49Lysosome_Homo sapiens_hsa041420.78782073
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78080352
51Sulfur metabolism_Homo sapiens_hsa009200.72541387
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.72507973
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71597407
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68705553
55Sphingolipid metabolism_Homo sapiens_hsa006000.68001470
56B cell receptor signaling pathway_Homo sapiens_hsa046620.66891784
57Antigen processing and presentation_Homo sapiens_hsa046120.66864432
58Mineral absorption_Homo sapiens_hsa049780.66851227
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66800979
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64813131
61Collecting duct acid secretion_Homo sapiens_hsa049660.60887178
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.58982907
63Primary immunodeficiency_Homo sapiens_hsa053400.58624421
64VEGF signaling pathway_Homo sapiens_hsa043700.58182234
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.54740184
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54698291
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.52714665
68Prolactin signaling pathway_Homo sapiens_hsa049170.51074951
69Complement and coagulation cascades_Homo sapiens_hsa046100.45812595
70ECM-receptor interaction_Homo sapiens_hsa045120.44736863
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43619962
72Renal cell carcinoma_Homo sapiens_hsa052110.43140302
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41905096
74T cell receptor signaling pathway_Homo sapiens_hsa046600.41764916
75Pancreatic cancer_Homo sapiens_hsa052120.39938619
76Dorso-ventral axis formation_Homo sapiens_hsa043200.39740312
77ABC transporters_Homo sapiens_hsa020100.39410458
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38932077
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36880302
80Glutathione metabolism_Homo sapiens_hsa004800.36730109
81Focal adhesion_Homo sapiens_hsa045100.36610631
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35319747
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32351561
84Proteasome_Homo sapiens_hsa030500.31685284
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30904599
86Acute myeloid leukemia_Homo sapiens_hsa052210.30547664
87Type II diabetes mellitus_Homo sapiens_hsa049300.30480113
88* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30105621
89Steroid biosynthesis_Homo sapiens_hsa001000.29811747
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28417752
91Fructose and mannose metabolism_Homo sapiens_hsa000510.28374626
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27095594
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26913985
94Prostate cancer_Homo sapiens_hsa052150.26184641
95Platelet activation_Homo sapiens_hsa046110.25317679
96Galactose metabolism_Homo sapiens_hsa000520.24960938
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24423908
98Proteoglycans in cancer_Homo sapiens_hsa052050.24090064
99Starch and sucrose metabolism_Homo sapiens_hsa005000.23231968
100* Insulin resistance_Homo sapiens_hsa049310.22814423
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22315820
102* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20580494
103TGF-beta signaling pathway_Homo sapiens_hsa043500.20446574
104* Pathways in cancer_Homo sapiens_hsa052000.20427404
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.20031759
106ErbB signaling pathway_Homo sapiens_hsa040120.19369391
107MAPK signaling pathway_Homo sapiens_hsa040100.19095406
108Small cell lung cancer_Homo sapiens_hsa052220.14934874
109* HTLV-I infection_Homo sapiens_hsa051660.13865584
110Epstein-Barr virus infection_Homo sapiens_hsa051690.12716108
111Chronic myeloid leukemia_Homo sapiens_hsa052200.11819717
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.09209033
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08924412
114Vibrio cholerae infection_Homo sapiens_hsa051100.08867662
115Arachidonic acid metabolism_Homo sapiens_hsa005900.07689312
116Viral carcinogenesis_Homo sapiens_hsa052030.07372165
117* FoxO signaling pathway_Homo sapiens_hsa040680.07184755
118Notch signaling pathway_Homo sapiens_hsa043300.06406970
119Folate biosynthesis_Homo sapiens_hsa007900.06272213
120* HIF-1 signaling pathway_Homo sapiens_hsa040660.05272988
121MicroRNAs in cancer_Homo sapiens_hsa052060.04649417
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.04486728

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