IL6ST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)5.25850999
2lymphangiogenesis (GO:0001946)4.77662716
3lymph vessel development (GO:0001945)4.72665985
4cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.19067073
5regulation of transforming growth factor beta2 production (GO:0032909)3.88822517
6protein heterotrimerization (GO:0070208)3.79604188
7apoptotic cell clearance (GO:0043277)3.64537126
8negative regulation of fibrinolysis (GO:0051918)3.57586793
9collagen fibril organization (GO:0030199)3.53424807
10retina vasculature morphogenesis in camera-type eye (GO:0061299)3.41199461
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.34332181
12cell migration involved in sprouting angiogenesis (GO:0002042)3.28971651
13basement membrane organization (GO:0071711)3.27577378
14peptidyl-glutamic acid carboxylation (GO:0017187)3.26825469
15protein carboxylation (GO:0018214)3.26825469
16blood vessel endothelial cell migration (GO:0043534)3.23892808
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.23818483
18axon extension involved in axon guidance (GO:0048846)3.23818483
19cell adhesion mediated by integrin (GO:0033627)3.16918085
20positive regulation of fatty acid beta-oxidation (GO:0032000)3.15098041
21growth hormone receptor signaling pathway (GO:0060396)3.05557735
22transcytosis (GO:0045056)3.01125345
23regulation of fibrinolysis (GO:0051917)2.97994087
24regulation of transforming growth factor beta1 production (GO:0032908)2.97475183
25low-density lipoprotein particle clearance (GO:0034383)2.96759543
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92751838
27positive regulation of endothelial cell apoptotic process (GO:2000353)2.92455927
28positive regulation of fatty acid oxidation (GO:0046321)2.91060599
29vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.91037585
30regulation of protein activation cascade (GO:2000257)2.90815686
31regulation of complement activation (GO:0030449)2.89709874
32skin morphogenesis (GO:0043589)2.89677974
33Golgi transport vesicle coating (GO:0048200)2.88629556
34COPI coating of Golgi vesicle (GO:0048205)2.88629556
35alpha-linolenic acid metabolic process (GO:0036109)2.84387332
36positive regulation of receptor recycling (GO:0001921)2.84280334
37regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.81992332
38glomerular filtration (GO:0003094)2.80985418
39renal filtration (GO:0097205)2.78656130
40sequestering of extracellular ligand from receptor (GO:0035581)2.78595784
41extracellular matrix assembly (GO:0085029)2.78486613
42endodermal cell differentiation (GO:0035987)2.77269932
43smooth muscle tissue development (GO:0048745)2.76242327
44positive regulation of fibroblast migration (GO:0010763)2.75997469
45plasma membrane repair (GO:0001778)2.75401649
46endocardial cushion development (GO:0003197)2.74370280
47cell migration involved in heart development (GO:0060973)2.72427223
48regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70595359
49epoxygenase P450 pathway (GO:0019373)2.70221862
50regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.70164287
51chondrocyte development (GO:0002063)2.68747282
52hypotonic response (GO:0006971)2.68515646
53positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67390546
54collagen metabolic process (GO:0032963)2.67025252
55leukocyte tethering or rolling (GO:0050901)2.66871753
56COPII vesicle coating (GO:0048208)2.66457797
57regulation of fatty acid beta-oxidation (GO:0031998)2.66345333
58platelet-derived growth factor receptor signaling pathway (GO:0048008)2.65745481
59extracellular fibril organization (GO:0043206)2.65691424
60regulation of cholesterol storage (GO:0010885)2.65169875
61sexual reproduction (GO:0019953)2.64094998
62cellular response to growth hormone stimulus (GO:0071378)2.63946012
63positive regulation of extracellular matrix organization (GO:1903055)2.62101298
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.60692759
65mesodermal cell differentiation (GO:0048333)2.59558022
66positive regulation of protein kinase C signaling (GO:0090037)2.59408953
67pericardium development (GO:0060039)2.58837328
68complement activation, alternative pathway (GO:0006957)2.58476946
69endothelial cell morphogenesis (GO:0001886)2.58024226
70collagen catabolic process (GO:0030574)2.57282175
71multicellular organismal macromolecule metabolic process (GO:0044259)2.56693287
72venous blood vessel morphogenesis (GO:0048845)2.56347518
73positive regulation of blood coagulation (GO:0030194)2.55261938
74positive regulation of hemostasis (GO:1900048)2.55261938
75phospholipid homeostasis (GO:0055091)2.53364544
76glucocorticoid biosynthetic process (GO:0006704)2.52948694
77fibroblast migration (GO:0010761)2.52481282
78regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.52368915
79glucocorticoid metabolic process (GO:0008211)2.51911787
80negative regulation of protein activation cascade (GO:2000258)2.51130149
81positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50555966
82chondrocyte proliferation (GO:0035988)2.49955610
83negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.47930849
84insulin-like growth factor receptor signaling pathway (GO:0048009)2.47002538
85negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.46906030
86multicellular organismal metabolic process (GO:0044236)2.46558895
87regulation of plasminogen activation (GO:0010755)2.45054941
88glomerular basement membrane development (GO:0032836)2.44037416
89blood vessel maturation (GO:0001955)2.43378133
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.42751969
91extracellular matrix disassembly (GO:0022617)2.42280396
92regulation of apoptotic cell clearance (GO:2000425)2.41677535
93fibril organization (GO:0097435)2.41617939
94protein localization to cell surface (GO:0034394)2.40910075
95multicellular organismal catabolic process (GO:0044243)2.40732886
96mesenchymal-epithelial cell signaling (GO:0060638)2.40546551
97positive regulation of osteoblast proliferation (GO:0033690)2.40482179
98potassium ion import (GO:0010107)2.40434596
99embryonic process involved in female pregnancy (GO:0060136)2.40272679
100positive regulation of p38MAPK cascade (GO:1900745)2.39904896
101regulation of integrin-mediated signaling pathway (GO:2001044)2.39884694
102negative regulation of complement activation (GO:0045916)2.38261212
103barbed-end actin filament capping (GO:0051016)2.37148138
104substrate-dependent cell migration (GO:0006929)2.36784407
105fatty acid transmembrane transport (GO:1902001)2.36625840
106cellular response to epinephrine stimulus (GO:0071872)2.36617389
107positive regulation of coagulation (GO:0050820)2.36380761
108regulation of tight junction assembly (GO:2000810)2.35980425
109regulation of cholesterol homeostasis (GO:2000188)2.35903312
110regulation of chemokine-mediated signaling pathway (GO:0070099)2.34427984
111sprouting angiogenesis (GO:0002040)2.33676486
112fibrinolysis (GO:0042730)2.32287579
113surfactant homeostasis (GO:0043129)2.32201429
114endothelial cell migration (GO:0043542)2.32103990
115regulation of steroid hormone biosynthetic process (GO:0090030)2.32102559
116protein localization to endosome (GO:0036010)2.30727223
117positive regulation of epithelial cell migration (GO:0010634)2.28688740
118negative regulation of chondrocyte differentiation (GO:0032331)2.28566403
119keratan sulfate catabolic process (GO:0042340)2.27968547
120bone trabecula formation (GO:0060346)2.27136674
121negative regulation of protein autophosphorylation (GO:0031953)2.26529776
122negative regulation of anoikis (GO:2000811)2.26379755
123epithelial cell-cell adhesion (GO:0090136)2.26100794
124adhesion of symbiont to host (GO:0044406)2.24767612
125glycoprotein catabolic process (GO:0006516)2.24595162
126reverse cholesterol transport (GO:0043691)2.24187387
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.23171021
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.23081941
129regulation of transforming growth factor beta production (GO:0071634)2.22810131
130regulation of fatty acid oxidation (GO:0046320)2.21501684
131extracellular matrix organization (GO:0030198)2.21282684
132positive regulation of endothelial cell migration (GO:0010595)2.20851709
133regulation of endothelial cell apoptotic process (GO:2000351)2.20729900
134hyaluronan catabolic process (GO:0030214)2.20610599
135extracellular structure organization (GO:0043062)2.20565498
136plasma lipoprotein particle clearance (GO:0034381)2.20094116
137fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19791134
138adherens junction assembly (GO:0034333)2.19625396
139branching involved in salivary gland morphogenesis (GO:0060445)2.19488091
140vesicle coating (GO:0006901)2.19366792
141regulation of sequestering of triglyceride (GO:0010889)2.18727075
142high-density lipoprotein particle remodeling (GO:0034375)2.18654172
143positive regulation of glycogen biosynthetic process (GO:0045725)2.18210423
144negative regulation of fatty acid transport (GO:2000192)2.17691140
145cell-substrate junction assembly (GO:0007044)2.17668760
146substrate adhesion-dependent cell spreading (GO:0034446)2.17011745
147hemidesmosome assembly (GO:0031581)2.17011521
148positive regulation of lipid catabolic process (GO:0050996)2.16104854
149ovulation from ovarian follicle (GO:0001542)2.14541108
150regulation of extracellular matrix disassembly (GO:0010715)2.13943151
151erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.13566751
152L-phenylalanine catabolic process (GO:0006559)2.13566751
153sulfur amino acid catabolic process (GO:0000098)2.13365439
154wound healing, spreading of epidermal cells (GO:0035313)2.12371419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.92252075
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.41417209
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.19185982
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.10399983
5CLOCK_20551151_ChIP-Seq_293T_Human3.08384188
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.95754850
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.85388734
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.81803408
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75372790
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58245871
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.55488838
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55476715
13* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22724033
14* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16190333
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.12387336
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.10206914
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05578964
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99877884
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90994631
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.83849125
21* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81109683
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80668091
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76699901
24CJUN_26792858_Chip-Seq_BT549_Human1.74003314
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.70757503
26* EP300_21415370_ChIP-Seq_HL-1_Mouse1.69769275
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69194407
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65970047
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64187611
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60769489
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59622506
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57908455
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.52078162
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50048676
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47749107
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46357306
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46357306
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.43638959
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.42704978
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.42704978
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38296757
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.35786535
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.34935798
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32033362
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.31185379
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30928115
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.29919855
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29265918
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29147112
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.28806220
51* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28662105
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.28427957
53* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28350784
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26714222
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25529677
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21920236
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21675877
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21257802
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20303234
60BRD4_25478319_ChIP-Seq_HGPS_Human1.20024198
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17293852
62* SOX2_20726797_ChIP-Seq_SW620_Human1.15709913
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14944797
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13635657
65ZNF263_19887448_ChIP-Seq_K562_Human1.13446550
66GATA1_22025678_ChIP-Seq_K562_Human1.13185217
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11769804
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11769804
69* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09576194
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08733454
71FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08353142
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07374204
73* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05809888
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05792119
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05402393
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05326131
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03494431
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03355759
79* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03183045
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02931712
81RACK7_27058665_Chip-Seq_MCF-7_Human1.02120515
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99867768
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99775809
84AR_21572438_ChIP-Seq_LNCaP_Human0.99277276
85YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97994679
86GBX2_23144817_ChIP-Seq_PC3_Human0.97552074
87* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97246904
88KDM2B_26808549_Chip-Seq_K562_Human0.96645395
89* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96591927
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.96567494
91* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96310391
92GATA1_19941826_ChIP-Seq_K562_Human0.96119761
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95222932
94TP53_16413492_ChIP-PET_HCT116_Human0.94777236
95RXR_22108803_ChIP-Seq_LS180_Human0.94587514
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94254689
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94189831
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94109910
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93539735
100AHR_22903824_ChIP-Seq_MCF-7_Human0.93459992
101DROSHA_22980978_ChIP-Seq_HELA_Human0.92807089
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92358267
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92358267
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92358267
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92088728
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91657476
107* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91600274
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90930944
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90179529
110TP53_18474530_ChIP-ChIP_U2OS_Human0.89663647
111LXR_22292898_ChIP-Seq_THP-1_Human0.89337134
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88406880
113KDM2B_26808549_Chip-Seq_DND41_Human0.88314393
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.88231971
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88209506
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88209506
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88191623
118* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88010932
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.87762928
120TP63_23658742_ChIP-Seq_EP156T_Human0.87653848
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87609410
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86906204
123* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86832656
124MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86345581
125* CDX2_20551321_ChIP-Seq_CACO-2_Human0.86187698
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.85077379
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84727610
128RUNX_20019798_ChIP-Seq_JUKART_Human0.84659918
129SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82973381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.14827906
2MP0010368_abnormal_lymphatic_system4.49505852
3MP0005275_abnormal_skin_tensile3.92710071
4MP0006054_spinal_hemorrhage3.85646542
5MP0003705_abnormal_hypodermis_morpholog3.81452823
6MP0005503_abnormal_tendon_morphology3.07756097
7MP0001879_abnormal_lymphatic_vessel3.02254628
8MP0004272_abnormal_basement_membrane3.00999232
9MP0000013_abnormal_adipose_tissue2.89213727
10MP0003279_aneurysm2.74921755
11MP0001958_emphysema2.42928943
12MP0003950_abnormal_plasma_membrane2.28993240
13MP0002139_abnormal_hepatobiliary_system1.95431345
14MP0003252_abnormal_bile_duct1.95199552
15MP0004130_abnormal_muscle_cell1.90291957
16MP0003566_abnormal_cell_adhesion1.90291663
17MP0009384_cardiac_valve_regurgitation1.89740768
18MP0005360_urolithiasis1.86916630
19MP0002060_abnormal_skin_morphology1.64468524
20MP0000003_abnormal_adipose_tissue1.63197794
21MP0005365_abnormal_bile_salt1.62413736
22MP0005670_abnormal_white_adipose1.58733977
23MP0002295_abnormal_pulmonary_circulatio1.53220384
24MP0005023_abnormal_wound_healing1.52523113
25MP0003941_abnormal_skin_development1.47700130
26MP0003191_abnormal_cellular_cholesterol1.47410646
27MP0000767_abnormal_smooth_muscle1.45519797
28MP0005623_abnormal_meninges_morphology1.43903843
29MP0003045_fibrosis1.43618013
30MP0003091_abnormal_cell_migration1.43412495
31* MP0003724_increased_susceptibility_to1.39103967
32MP0005085_abnormal_gallbladder_physiolo1.37027961
33MP0004185_abnormal_adipocyte_glucose1.35463765
34MP0001243_abnormal_dermal_layer1.35054339
35MP0002108_abnormal_muscle_morphology1.33334370
36MP0010329_abnormal_lipoprotein_level1.33116363
37MP0005409_darkened_coat_color1.32897297
38MP0005375_adipose_tissue_phenotype1.32878864
39* MP0003300_gastrointestinal_ulcer1.30720147
40MP0003868_abnormal_feces_composition1.28540142
41MP0010352_gastrointestinal_tract_polyps1.28086820
42MP0004233_abnormal_muscle_weight1.25094878
43MP0005666_abnormal_adipose_tissue1.24499323
44MP0002254_reproductive_system_inflammat1.20888204
45MP0000751_myopathy1.18235206
46MP0004084_abnormal_cardiac_muscle1.18124084
47MP0002168_other_aberrant_phenotype1.15913240
48MP0005257_abnormal_intraocular_pressure1.15513616
49* MP0005508_abnormal_skeleton_morphology1.15250132
50MP0003303_peritoneal_inflammation1.09784774
51* MP0002896_abnormal_bone_mineralization1.09676050
52MP0002128_abnormal_blood_circulation1.06608817
53MP0001915_intracranial_hemorrhage1.02838118
54MP0005167_abnormal_blood-brain_barrier1.02819365
55MP0002138_abnormal_hepatobiliary_system1.00061428
56MP0000733_abnormal_muscle_development0.99840940
57MP0001348_abnormal_lacrimal_gland0.96679230
58MP0008875_abnormal_xenobiotic_pharmacok0.95941897
59MP0003828_pulmonary_edema0.94661666
60MP0005595_abnormal_vascular_smooth0.91503474
61* MP0000609_abnormal_liver_physiology0.89734548
62MP0002837_dystrophic_cardiac_calcinosis0.89699538
63MP0005164_abnormal_response_to0.88692412
64MP0001299_abnormal_eye_distance/0.88600789
65MP0009840_abnormal_foam_cell0.88273303
66MP0005076_abnormal_cell_differentiation0.87225320
67MP0004087_abnormal_muscle_fiber0.86828803
68MP0001614_abnormal_blood_vessel0.86730184
69MP0001542_abnormal_bone_strength0.86557481
70MP0002332_abnormal_exercise_endurance0.86523422
71MP0000249_abnormal_blood_vessel0.85602344
72MP0001661_extended_life_span0.85339018
73MP0009250_abnormal_appendicular_skeleto0.85057692
74MP0000750_abnormal_muscle_regeneration0.84700853
75MP0010630_abnormal_cardiac_muscle0.84062766
76MP0009053_abnormal_anal_canal0.80485061
77MP0004858_abnormal_nervous_system0.80294337
78* MP0001533_abnormal_skeleton_physiology0.80001621
79MP0004484_altered_response_of0.79324663
80* MP0005390_skeleton_phenotype0.78599591
81* MP0001851_eye_inflammation0.77751037
82MP0000343_altered_response_to0.77519615
83MP0009278_abnormal_bone_marrow0.75792250
84MP0001849_ear_inflammation0.74699302
85* MP0002925_abnormal_cardiovascular_devel0.74668316
86MP0006138_congestive_heart_failure0.74250407
87MP0004782_abnormal_surfactant_physiolog0.74232953
88MP0005083_abnormal_biliary_tract0.74222692
89MP0002127_abnormal_cardiovascular_syste0.73652548
90MP0009780_abnormal_chondrocyte_physiolo0.73516535
91MP0003453_abnormal_keratinocyte_physiol0.73175235
92MP0003329_amyloid_beta_deposits0.72741365
93MP0002118_abnormal_lipid_homeostasis0.71889990
94* MP0002998_abnormal_bone_remodeling0.71643334
95MP0001175_abnormal_lung_morphology0.71433580
96MP0000759_abnormal_skeletal_muscle0.70744233
97MP0005319_abnormal_enzyme/_coenzyme0.70284342
98MP0000428_abnormal_craniofacial_morphol0.70071605
99MP0002089_abnormal_postnatal_growth/wei0.70022172
100MP0003448_altered_tumor_morphology0.69805991
101MP0005058_abnormal_lysosome_morphology0.69752945
102MP0008775_abnormal_heart_ventricle0.69684125
103MP0010386_abnormal_urinary_bladder0.68089539
104MP0000534_abnormal_ureter_morphology0.67686478
105MP0004036_abnormal_muscle_relaxation0.67479578
106* MP0002115_abnormal_skeleton_extremities0.66980248
107MP0000163_abnormal_cartilage_morphology0.66864817
108MP0002877_abnormal_melanocyte_morpholog0.65993461
109MP0004510_myositis0.65981462
110MP0004883_abnormal_blood_vessel0.65965032
111MP0002971_abnormal_brown_adipose0.65962972
112MP0005165_increased_susceptibility_to0.65942641
113MP0002166_altered_tumor_susceptibility0.65609784
114MP0001544_abnormal_cardiovascular_syste0.65465871
115MP0005385_cardiovascular_system_phenoty0.65465871
116* MP0003385_abnormal_body_wall0.64575228
117MP0005197_abnormal_uvea_morphology0.63077155
118MP0002133_abnormal_respiratory_system0.63014052
119MP0005388_respiratory_system_phenotype0.63014052
120MP0002796_impaired_skin_barrier0.62739284
121MP0000681_abnormal_thyroid_gland0.62731725
122* MP0003795_abnormal_bone_structure0.62713255
123MP0000639_abnormal_adrenal_gland0.62232497
124MP0005620_abnormal_muscle_contractility0.61809538
125MP0000604_amyloidosis0.60153790
126* MP0002933_joint_inflammation0.59823562
127* MP0002113_abnormal_skeleton_development0.59509071
128MP0005330_cardiomyopathy0.59318464
129MP0001270_distended_abdomen0.59194429
130* MP0000598_abnormal_liver_morphology0.59118613
131MP0002972_abnormal_cardiac_muscle0.59002144

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.85271444
2Premature rupture of membranes (HP:0001788)5.70186817
3Broad metatarsal (HP:0001783)5.34560281
4Nonimmune hydrops fetalis (HP:0001790)4.61789748
5Aortic dissection (HP:0002647)4.40532782
6Cerebral aneurysm (HP:0004944)4.30359461
7Aortic aneurysm (HP:0004942)4.08047260
8Peritonitis (HP:0002586)3.84280428
9Deep venous thrombosis (HP:0002625)3.83775469
10Shallow orbits (HP:0000586)3.74406616
11Ankle contracture (HP:0006466)3.70578247
12Mitral valve prolapse (HP:0001634)3.37461228
13Increased connective tissue (HP:0009025)3.22824291
14Atrophic scars (HP:0001075)3.16677517
15Dilatation of the ascending aorta (HP:0005111)3.06473547
16Aneurysm (HP:0002617)2.95632808
17Soft skin (HP:0000977)2.93950261
18Bladder diverticulum (HP:0000015)2.89005249
19Type 1 muscle fiber predominance (HP:0003803)2.87120206
20Lymphangioma (HP:0100764)2.86369885
21Hypoplastic ischia (HP:0003175)2.86145071
22Short hallux (HP:0010109)2.84391173
23Abnormality of the ischium (HP:0003174)2.77635517
24Cervical subluxation (HP:0003308)2.76941095
25Vascular tortuosity (HP:0004948)2.67730940
26Hematochezia (HP:0002573)2.66223042
27Aplasia/Hypoplasia of the hallux (HP:0008362)2.62319785
28Fragile skin (HP:0001030)2.59126321
29Blue sclerae (HP:0000592)2.55305453
30Arterial tortuosity (HP:0005116)2.52983079
31Hypoalphalipoproteinemia (HP:0003233)2.51200770
32Abnormality of the peritoneum (HP:0002585)2.47926878
33Cardiovascular calcification (HP:0011915)2.45950537
34Myocardial infarction (HP:0001658)2.45702559
35Spinal rigidity (HP:0003306)2.42721124
36Genu recurvatum (HP:0002816)2.41784635
37Ectopia lentis (HP:0001083)2.40823972
38Short nail (HP:0001799)2.39093672
39Hyporeflexia of lower limbs (HP:0002600)2.36466944
40Striae distensae (HP:0001065)2.35813025
41Follicular hyperkeratosis (HP:0007502)2.33374644
42Complement deficiency (HP:0004431)2.32682920
43Venous abnormality (HP:0002624)2.32380619
44Disproportionate tall stature (HP:0001519)2.32023964
45Hypoplasia of the iris (HP:0007676)2.31400398
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30815508
47Relative macrocephaly (HP:0004482)2.30789958
48Increased variability in muscle fiber diameter (HP:0003557)2.25896912
49Spinal cord lesions (HP:0100561)2.25527327
50Syringomyelia (HP:0003396)2.25527327
51Aortic regurgitation (HP:0001659)2.25288033
52Xanthomatosis (HP:0000991)2.24209495
53Venous insufficiency (HP:0005293)2.23042063
54Mitral stenosis (HP:0001718)2.22706130
55Abnormality of the acetabulum (HP:0003170)2.21118025
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.19609259
57Osteolytic defects of the hand bones (HP:0009699)2.19609259
58Wrist flexion contracture (HP:0001239)2.18272366
59Esophageal varix (HP:0002040)2.14576631
60Right ventricular cardiomyopathy (HP:0011663)2.13442029
61Hyperextensible skin (HP:0000974)2.11888898
62Mitral regurgitation (HP:0001653)2.11102596
63Wormian bones (HP:0002645)2.09832008
64Camptodactyly of toe (HP:0001836)2.08193072
65Absent frontal sinuses (HP:0002688)2.07743485
66Abnormality of carpal bone ossification (HP:0006257)2.06570263
67Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05889438
68Overgrowth (HP:0001548)2.02306945
69Abnormal delivery (HP:0001787)2.01010001
70Abnormality of the intrinsic pathway (HP:0010989)2.00703820
71Polycythemia (HP:0001901)1.99974552
72Aortic valve stenosis (HP:0001650)1.98272648
73Wide anterior fontanel (HP:0000260)1.97845406
74Mildly elevated creatine phosphokinase (HP:0008180)1.96968017
75Abnormality of skeletal muscle fiber size (HP:0012084)1.96631197
76Abnormal ossification of hand bones (HP:0005921)1.96567417
77Biconcave vertebral bodies (HP:0004586)1.95847649
78Limited hip movement (HP:0008800)1.93296242
79Vertebral compression fractures (HP:0002953)1.91632588
80Muscle fiber splitting (HP:0003555)1.91394418
81Infantile muscular hypotonia (HP:0008947)1.91244644
82Neonatal short-limb short stature (HP:0008921)1.89462573
83Slender build (HP:0001533)1.89440070
84Persistence of primary teeth (HP:0006335)1.89221399
85Thin bony cortex (HP:0002753)1.87943528
86Bowel diverticulosis (HP:0005222)1.87154626
87Large earlobe (HP:0009748)1.87094761
88Flat acetabular roof (HP:0003180)1.85995680
89Ovoid vertebral bodies (HP:0003300)1.85667735
90Intrahepatic cholestasis (HP:0001406)1.85382540
91Round ear (HP:0100830)1.83422842
92Abnormality of the common coagulation pathway (HP:0010990)1.83140510
93Joint laxity (HP:0001388)1.82689137
94Coxa vara (HP:0002812)1.82137072
95Ulnar bowing (HP:0003031)1.81986473
96Coronal craniosynostosis (HP:0004440)1.81501282
97Broad face (HP:0000283)1.81413390
98Skin nodule (HP:0200036)1.81378635
99Thoracolumbar scoliosis (HP:0002944)1.78396847
100Difficulty running (HP:0009046)1.76666512
101Abnormality of complement system (HP:0005339)1.76644963
102Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76272244
103Abnormality of dentin (HP:0010299)1.76158641
104Vertebral arch anomaly (HP:0008438)1.75880080
105Short 4th metacarpal (HP:0010044)1.75614830
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75614830
107Joint hemorrhage (HP:0005261)1.75540258
108Vascular calcification (HP:0004934)1.75219570
109Delayed closure of the anterior fontanelle (HP:0001476)1.74998038
110Buphthalmos (HP:0000557)1.73836844
111Elbow flexion contracture (HP:0002987)1.73765713
112Scapular winging (HP:0003691)1.73155622
113Abnormality of the 4th metacarpal (HP:0010012)1.73135461
114Mucopolysacchariduria (HP:0008155)1.72848466
115Urinary glycosaminoglycan excretion (HP:0003541)1.72848466
116Turricephaly (HP:0000262)1.72178974
117Prolonged partial thromboplastin time (HP:0003645)1.71822768
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71508651
119Ventricular tachycardia (HP:0004756)1.71463951
120Spondylolisthesis (HP:0003302)1.70510185
121Rhizomelia (HP:0008905)1.70331019
122Abnormal hand bone ossification (HP:0010660)1.69395056
123Long toe (HP:0010511)1.68246617
124Alopecia of scalp (HP:0002293)1.67778233
125Asymmetric septal hypertrophy (HP:0001670)1.67218525
126Knee flexion contracture (HP:0006380)1.66843664
127Difficulty climbing stairs (HP:0003551)1.66688686
128Broad ribs (HP:0000885)1.66019302
129Inguinal hernia (HP:0000023)1.66012798
130Spinal cord compression (HP:0002176)1.65827729
131Hypolipoproteinemia (HP:0010981)1.65588322
132Glucose intolerance (HP:0000833)1.64825025
133Deviation of the hallux (HP:0010051)1.64571443
134Menorrhagia (HP:0000132)1.63445882
135Pulmonic stenosis (HP:0001642)1.61747576
136Nephritis (HP:0000123)1.61413911
137Spontaneous hematomas (HP:0007420)1.59714879
138Osteoarthritis (HP:0002758)1.59403845
139Short clavicles (HP:0000894)1.58559817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.73506587
2TIE14.08612836
3TGFBR23.50939116
4ERN13.15867987
5TTN2.96608453
6TRIB32.90336651
7SIK12.76571658
8AKT32.62058180
9PDGFRA2.37931370
10RIPK12.32965955
11LATS12.32118827
12PKN22.26211798
13DDR22.17402439
14FGFR42.15615840
15PRPF4B2.06104375
16EPHB11.99972763
17EPHA31.85033347
18STK381.66194130
19PTK61.61951391
20CAMK1D1.54749717
21FER1.48425749
22FGFR21.43165619
23FGFR31.37241495
24TGFBR11.36300848
25JAK31.34731290
26EPHB21.24962186
27PTK21.23136525
28ICK1.22563593
29NEK91.20761041
30CAMK1G1.20277911
31LATS21.16233785
32MELK1.15517165
33CDC42BPA1.13089453
34STK38L1.11961388
35RET1.11196688
36DMPK1.08579488
37FRK1.06627267
38PDGFRB1.06028218
39FLT31.06027760
40* JAK10.97756574
41LMTK20.96743314
42MET0.94552197
43PRKCH0.93462948
44TYK20.92571960
45PAK20.91164938
46INSRR0.88618990
47SGK20.87390961
48BMX0.87140936
49TRPM70.85134455
50MAP2K30.84554222
51MAP3K60.84071902
52ROCK20.83852257
53MAP3K30.82450634
54FGFR10.81168855
55MTOR0.78981670
56ZAP700.77693658
57PTK2B0.74285834
58LRRK20.73701793
59MOS0.73661214
60PIK3CA0.73480973
61KSR20.72913550
62NTRK10.71729445
63SCYL20.71620857
64STK30.70870801
65PAK30.69388557
66RPS6KA20.66854121
67MAP3K70.66821286
68SGK2230.65123076
69SGK4940.65123076
70* JAK20.63990079
71PRKD10.63885011
72PAK40.63442730
73MAP2K10.62406682
74MYLK0.62007146
75BCKDK0.60366997
76TESK10.56932533
77MAP3K120.56390566
78GSK3A0.55942190
79NEK60.55934595
80EEF2K0.55761456
81MAPK120.55143456
82MAP3K100.54703627
83LIMK10.54509162
84PAK60.54179255
85MST1R0.53923195
86MARK20.53616595
87PRKAA20.53354355
88CSK0.53017781
89IGF1R0.52540925
90CAMKK20.52267604
91MAPK150.52197007
92MAP3K130.51544903
93CDK120.50875617
94PDK20.50801099
95ROCK10.49995078
96MAP3K20.49135480
97PIK3CG0.48353329
98MAP3K10.46910088
99INSR0.46618940
100CDK60.46224193
101STK100.44458407
102CDK90.44297430
103PRKD20.43893171
104TBK10.43717178
105SRC0.42289210
106TAOK20.42004352
107SGK30.41348543
108EPHA20.40180163
109EGFR0.39811917
110ADRBK10.39344272
111RPS6KA40.39169488
112ABL20.38856924
113PHKG10.37724102
114PHKG20.37724102
115KSR10.37035579
116MAPK70.36681845
117PRKD30.35006273
118ERBB20.34742279
119GRK50.34329907
120ITK0.34222826
121MAPKAPK30.34193309
122EIF2AK30.33812070
123WNK10.32831432
124KIT0.31429369
125PRKG20.30460141
126ERBB40.30037415
127DAPK20.29177669
128CSF1R0.26671104
129TAOK30.25774249
130NLK0.23963895
131PDPK10.23540770

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.94613063
2Complement and coagulation cascades_Homo sapiens_hsa046102.66729581
3ECM-receptor interaction_Homo sapiens_hsa045122.27588720
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.17363424
5Malaria_Homo sapiens_hsa051441.98933531
6PPAR signaling pathway_Homo sapiens_hsa033201.86924163
7Focal adhesion_Homo sapiens_hsa045101.81783830
8Fatty acid degradation_Homo sapiens_hsa000711.78090154
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75400552
10Arginine biosynthesis_Homo sapiens_hsa002201.70747077
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68316244
12Staphylococcus aureus infection_Homo sapiens_hsa051501.66037990
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51176961
14Bile secretion_Homo sapiens_hsa049761.50657276
15Caffeine metabolism_Homo sapiens_hsa002321.44728540
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43806852
17Fatty acid metabolism_Homo sapiens_hsa012121.43100243
18Tryptophan metabolism_Homo sapiens_hsa003801.41456305
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35129544
20Adherens junction_Homo sapiens_hsa045201.32428282
21Amoebiasis_Homo sapiens_hsa051461.30962083
22Protein digestion and absorption_Homo sapiens_hsa049741.28089833
23Proteoglycans in cancer_Homo sapiens_hsa052051.23598033
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22296289
25Insulin resistance_Homo sapiens_hsa049311.21823178
26ABC transporters_Homo sapiens_hsa020101.18345040
27Dilated cardiomyopathy_Homo sapiens_hsa054141.15833291
28Propanoate metabolism_Homo sapiens_hsa006401.15620468
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14068851
30Renal cell carcinoma_Homo sapiens_hsa052111.13833613
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12323322
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.08987417
33Lysine degradation_Homo sapiens_hsa003101.08458114
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06768887
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06571712
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06286058
37Glioma_Homo sapiens_hsa052141.00931877
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95985881
39Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95860420
40Circadian rhythm_Homo sapiens_hsa047100.93980194
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93897413
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.93645269
43Starch and sucrose metabolism_Homo sapiens_hsa005000.90158912
44Endometrial cancer_Homo sapiens_hsa052130.89963928
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.89401482
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.89397398
47Small cell lung cancer_Homo sapiens_hsa052220.88990332
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88686768
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88386052
50Thyroid cancer_Homo sapiens_hsa052160.87988712
51Butanoate metabolism_Homo sapiens_hsa006500.87590961
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86313080
53Other glycan degradation_Homo sapiens_hsa005110.84901059
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84769470
55African trypanosomiasis_Homo sapiens_hsa051430.84217254
56Chemical carcinogenesis_Homo sapiens_hsa052040.83018714
57TNF signaling pathway_Homo sapiens_hsa046680.81782815
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81081520
59Prolactin signaling pathway_Homo sapiens_hsa049170.80591434
60Pertussis_Homo sapiens_hsa051330.80179671
61Fatty acid biosynthesis_Homo sapiens_hsa000610.79283457
62Toxoplasmosis_Homo sapiens_hsa051450.78698532
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78615094
64Choline metabolism in cancer_Homo sapiens_hsa052310.77808010
65Gap junction_Homo sapiens_hsa045400.77369621
66Rap1 signaling pathway_Homo sapiens_hsa040150.75835003
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.75766056
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75100043
69Inositol phosphate metabolism_Homo sapiens_hsa005620.73716519
70GnRH signaling pathway_Homo sapiens_hsa049120.73558344
71FoxO signaling pathway_Homo sapiens_hsa040680.72852992
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72645851
73Estrogen signaling pathway_Homo sapiens_hsa049150.72632043
74TGF-beta signaling pathway_Homo sapiens_hsa043500.71797003
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.70962240
76Chronic myeloid leukemia_Homo sapiens_hsa052200.70389162
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69842720
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67730121
79Platelet activation_Homo sapiens_hsa046110.67581415
80Renin secretion_Homo sapiens_hsa049240.67538479
81Dorso-ventral axis formation_Homo sapiens_hsa043200.66185010
82beta-Alanine metabolism_Homo sapiens_hsa004100.65453129
83Peroxisome_Homo sapiens_hsa041460.64936673
84Lysosome_Homo sapiens_hsa041420.64085358
85Viral myocarditis_Homo sapiens_hsa054160.63848061
86Pancreatic cancer_Homo sapiens_hsa052120.63826668
87Non-small cell lung cancer_Homo sapiens_hsa052230.63780844
88Osteoclast differentiation_Homo sapiens_hsa043800.63655687
89AMPK signaling pathway_Homo sapiens_hsa041520.63462860
90Endocytosis_Homo sapiens_hsa041440.62942082
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62817314
92ErbB signaling pathway_Homo sapiens_hsa040120.61480722
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.60860083
94Ras signaling pathway_Homo sapiens_hsa040140.60786515
95VEGF signaling pathway_Homo sapiens_hsa043700.60755941
96Fat digestion and absorption_Homo sapiens_hsa049750.60388636
97HIF-1 signaling pathway_Homo sapiens_hsa040660.60209348
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59606757
99Insulin signaling pathway_Homo sapiens_hsa049100.59089083
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.58927019
101Bladder cancer_Homo sapiens_hsa052190.58482541
102Melanogenesis_Homo sapiens_hsa049160.58375154
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56944200
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56551398
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56389786
106Hepatitis C_Homo sapiens_hsa051600.56278954
107Prion diseases_Homo sapiens_hsa050200.56177826
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.56016979
109Sphingolipid metabolism_Homo sapiens_hsa006000.54393190
110Long-term potentiation_Homo sapiens_hsa047200.54279618
111Vitamin digestion and absorption_Homo sapiens_hsa049770.53944718
112Ovarian steroidogenesis_Homo sapiens_hsa049130.53238367
113Mineral absorption_Homo sapiens_hsa049780.52507826
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52320509
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52133426
116Phenylalanine metabolism_Homo sapiens_hsa003600.51854316
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50820897
118Histidine metabolism_Homo sapiens_hsa003400.49797491
119Glycerolipid metabolism_Homo sapiens_hsa005610.49306621
120MAPK signaling pathway_Homo sapiens_hsa040100.49108304
121Axon guidance_Homo sapiens_hsa043600.48506743
122Pancreatic secretion_Homo sapiens_hsa049720.48045205
123mTOR signaling pathway_Homo sapiens_hsa041500.47408005
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47139353
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46432726
126Acute myeloid leukemia_Homo sapiens_hsa052210.46336030
127Melanoma_Homo sapiens_hsa052180.45871374
128Selenocompound metabolism_Homo sapiens_hsa004500.45787651
129Pathways in cancer_Homo sapiens_hsa052000.45587196
130Type II diabetes mellitus_Homo sapiens_hsa049300.44925117
131Retinol metabolism_Homo sapiens_hsa008300.44826068
132Hippo signaling pathway_Homo sapiens_hsa043900.44606281
133Renin-angiotensin system_Homo sapiens_hsa046140.43757986
134MicroRNAs in cancer_Homo sapiens_hsa052060.43346880
135Glucagon signaling pathway_Homo sapiens_hsa049220.42874865
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42835965
137Basal cell carcinoma_Homo sapiens_hsa052170.42006658
138Thyroid hormone synthesis_Homo sapiens_hsa049180.40276388
139Prostate cancer_Homo sapiens_hsa052150.40159416
140Pyruvate metabolism_Homo sapiens_hsa006200.39690809
141Tight junction_Homo sapiens_hsa045300.38650621
142Sulfur metabolism_Homo sapiens_hsa009200.37842809
143* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37802766

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