IL7R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.13723158
2* negative regulation of cell killing (GO:0031342)7.00944074
3* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.00944074
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.26853988
5negative T cell selection (GO:0043383)6.07152809
6negative thymic T cell selection (GO:0045060)5.91698163
7regulation of gamma-delta T cell differentiation (GO:0045586)5.73613195
8positive thymic T cell selection (GO:0045059)5.49017444
9regulation of gamma-delta T cell activation (GO:0046643)5.35573561
10regulation of isotype switching to IgG isotypes (GO:0048302)5.34020441
11regulation of B cell receptor signaling pathway (GO:0050855)5.14960103
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.02368470
13interferon-gamma production (GO:0032609)4.95951725
14positive T cell selection (GO:0043368)4.89497666
15tolerance induction (GO:0002507)4.83035130
16T cell migration (GO:0072678)4.82353691
17thymic T cell selection (GO:0045061)4.75404799
18T cell selection (GO:0045058)4.63431312
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.57052594
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57052594
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.56003370
22leukocyte aggregation (GO:0070486)4.32610441
23positive regulation of isotype switching (GO:0045830)4.22655199
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.13046430
25CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.11323554
26T-helper cell differentiation (GO:0042093)4.11323554
27antigen processing and presentation of endogenous antigen (GO:0019883)4.10096471
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.09864281
29regulation of regulatory T cell differentiation (GO:0045589)4.05439979
30regulation of alpha-beta T cell proliferation (GO:0046640)4.03486469
31positive regulation of B cell mediated immunity (GO:0002714)3.96904860
32positive regulation of immunoglobulin mediated immune response (GO:0002891)3.96904860
33B cell receptor signaling pathway (GO:0050853)3.95569507
34neutrophil activation involved in immune response (GO:0002283)3.95221039
35positive regulation of natural killer cell mediated immunity (GO:0002717)3.90543056
36positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.90543056
37T cell receptor signaling pathway (GO:0050852)3.87673693
38regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.87217369
39T cell costimulation (GO:0031295)3.84353356
40regulation of natural killer cell mediated immunity (GO:0002715)3.82890124
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.82890124
42lymphocyte costimulation (GO:0031294)3.80949520
43negative regulation of interleukin-12 production (GO:0032695)3.80343182
44activated T cell proliferation (GO:0050798)3.79632698
45* response to interleukin-15 (GO:0070672)3.79392283
46positive regulation of DNA recombination (GO:0045911)3.79216425
47regulation of response to interferon-gamma (GO:0060330)3.78740418
48regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.74091691
49* cellular response to interleukin-15 (GO:0071350)3.70794179
50alpha-beta T cell differentiation involved in immune response (GO:0002293)3.69801955
51alpha-beta T cell activation involved in immune response (GO:0002287)3.69801955
52T cell differentiation involved in immune response (GO:0002292)3.69801955
53NIK/NF-kappaB signaling (GO:0038061)3.69375890
54* negative regulation of lymphocyte mediated immunity (GO:0002707)3.69086288
55antigen receptor-mediated signaling pathway (GO:0050851)3.67220723
56regulation of T cell receptor signaling pathway (GO:0050856)3.66245611
57positive regulation of humoral immune response (GO:0002922)3.62687479
58regulation of B cell differentiation (GO:0045577)3.60491175
59regulation of chronic inflammatory response (GO:0002676)3.59133123
60neutrophil activation (GO:0042119)3.56644592
61regulation of isotype switching (GO:0045191)3.56368036
62* negative regulation of T cell mediated immunity (GO:0002710)3.56300843
63positive regulation of interleukin-17 production (GO:0032740)3.55209991
64* regulation of T cell mediated cytotoxicity (GO:0001914)3.54714225
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.54063799
66regulation of immunoglobulin mediated immune response (GO:0002889)3.53099181
67regulation of interleukin-12 biosynthetic process (GO:0045075)3.52963749
68granulocyte activation (GO:0036230)3.48686654
69regulation of B cell mediated immunity (GO:0002712)3.47160603
70positive regulation of natural killer cell differentiation (GO:0032825)3.46320089
71regulation of T cell tolerance induction (GO:0002664)3.46248960
72positive regulation of interleukin-2 production (GO:0032743)3.44853202
73positive regulation of granulocyte differentiation (GO:0030854)3.43450436
74interferon-gamma-mediated signaling pathway (GO:0060333)3.43319136
75leukocyte cell-cell adhesion (GO:0007159)3.41373462
76positive regulation of tolerance induction (GO:0002645)3.40875028
77regulation of immune response to tumor cell (GO:0002837)3.40263071
78regulation of response to tumor cell (GO:0002834)3.40263071
79positive regulation of response to tumor cell (GO:0002836)3.40263071
80positive regulation of immune response to tumor cell (GO:0002839)3.40263071
81natural killer cell activation (GO:0030101)3.39324930
82cellular response to type I interferon (GO:0071357)3.37942917
83regulation of tolerance induction (GO:0002643)3.37394310
84* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.37259699
85positive regulation of mast cell activation (GO:0033005)3.35750067
86regulation of activation of Janus kinase activity (GO:0010533)3.33445371
87alpha-beta T cell activation (GO:0046631)3.33431498
88lymphocyte migration (GO:0072676)3.33058448
89negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.32366759
90mast cell activation (GO:0045576)3.28825417
91antigen processing and presentation via MHC class Ib (GO:0002475)3.27815536
92regulation of interleukin-2 biosynthetic process (GO:0045076)3.25805212
93positive regulation of cell killing (GO:0031343)3.25569666
94myeloid dendritic cell activation (GO:0001773)3.23848732
95alpha-beta T cell differentiation (GO:0046632)3.22047837
96T cell activation involved in immune response (GO:0002286)3.21305692
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19769879
98* negative regulation of leukocyte mediated immunity (GO:0002704)3.19478549
99cellular extravasation (GO:0045123)3.15159699
100negative regulation of T-helper cell differentiation (GO:0045623)3.14191789
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14191789
102* regulation of cell killing (GO:0031341)3.14028728
103* B cell proliferation (GO:0042100)3.12886866
104negative regulation of T cell receptor signaling pathway (GO:0050860)3.10766079
105positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.10123027
106myeloid dendritic cell differentiation (GO:0043011)3.07248570
107heterotypic cell-cell adhesion (GO:0034113)3.06463467
108modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05721575
109positive regulation by organism of defense response of other organism involved in symbiotic interact3.05721575
110modulation by symbiont of host immune response (GO:0052553)3.05721575
111positive regulation by symbiont of host defense response (GO:0052509)3.05721575
112modulation by symbiont of host defense response (GO:0052031)3.05721575
113modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05721575
114positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05417045
115response to muramyl dipeptide (GO:0032495)3.05072530
116regulation of alpha-beta T cell activation (GO:0046634)3.04391308
117response to type I interferon (GO:0034340)3.03975442
118macrophage activation involved in immune response (GO:0002281)3.03940244
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.03881519
120regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.02591689
121positive regulation of T cell mediated cytotoxicity (GO:0001916)3.02472413
122type I interferon signaling pathway (GO:0060337)3.01595641
123negative regulation of innate immune response (GO:0045824)3.00523133
124defense response to protozoan (GO:0042832)2.94977483
125detection of other organism (GO:0098543)2.93639873
126positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.93282437
127positive regulation of T cell mediated immunity (GO:0002711)2.92959695
128CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.92487040
129dendritic cell chemotaxis (GO:0002407)2.92304904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.13884489
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.96052166
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.69330189
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.67499532
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.43015257
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.18149282
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.96507374
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.92299760
9* RUNX_20019798_ChIP-Seq_JUKART_Human3.50404425
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.47255502
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.44913312
12* IRF8_27001747_Chip-Seq_BMDM_Mouse3.39278969
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.26803891
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22526016
15* MYB_26560356_Chip-Seq_TH2_Human3.06875295
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98023123
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94468627
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.72351165
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55947892
20* MAF_26560356_Chip-Seq_TH1_Human2.50222299
21MYB_26560356_Chip-Seq_TH1_Human2.48203681
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47122734
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31711168
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28408754
25MYC_22102868_ChIP-Seq_BL_Human2.26671870
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11042783
27UTX_26944678_Chip-Seq_JUKART_Human2.09145743
28* SPI1_23547873_ChIP-Seq_NB4_Human2.04458771
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.02967549
30GATA3_27048872_Chip-Seq_THYMUS_Human1.94040567
31SCL_19346495_ChIP-Seq_HPC-7_Human1.91228524
32VDR_21846776_ChIP-Seq_THP-1_Human1.90186019
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89117086
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85451002
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82725911
36VDR_24763502_ChIP-Seq_THP-1_Human1.82269849
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80867966
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70989098
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70545716
40TCF7_22412390_ChIP-Seq_EML_Mouse1.66597733
41PU_27001747_Chip-Seq_BMDM_Mouse1.64603900
42MAF_26560356_Chip-Seq_TH2_Human1.62637372
43* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62059261
44SPI1_23127762_ChIP-Seq_K562_Human1.55795538
45VDR_24787735_ChIP-Seq_THP-1_Human1.54775172
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53691055
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44439249
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.43944805
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42436995
50* GATA3_26560356_Chip-Seq_TH2_Human1.42179795
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42128636
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39701063
53* NOTCH1_21737748_ChIP-Seq_TLL_Human1.37629438
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37290409
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36665660
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36384722
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35970295
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30191958
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28352139
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25837241
61* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21819075
62KDM2B_26808549_Chip-Seq_DND41_Human1.17023941
63GATA1_22025678_ChIP-Seq_K562_Human1.15677822
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14421816
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14111117
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13961483
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11948440
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05097629
69E2F7_22180533_ChIP-Seq_HELA_Human1.02504470
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00913091
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00048131
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98598823
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97961947
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96406578
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96243062
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95072399
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93656086
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93130773
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91675400
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90493941
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90445147
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.89846129
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.79789582
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77144763
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.76669260
86GATA3_26560356_Chip-Seq_TH1_Human0.75758044
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.74699016
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73916549
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73865016
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.73291192
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71821047
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.70009581
93TFEB_21752829_ChIP-Seq_HELA_Human0.69385876
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.68798740
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.68308130
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.67965374
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67613115
98BCL6_27268052_Chip-Seq_Bcells_Human0.67499078
99GATA2_19941826_ChIP-Seq_K562_Human0.67256000
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.67007562
101CIITA_25753668_ChIP-Seq_RAJI_Human0.66881362
102STAT1_20625510_ChIP-Seq_HELA_Human0.65770109
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64551223
104* SMRT_27268052_Chip-Seq_Bcells_Human0.64254363
105GATA1_19941826_ChIP-Seq_K562_Human0.63000886
106NCOR1_26117541_ChIP-Seq_K562_Human0.62742451
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.60272894
108EGR1_19032775_ChIP-ChIP_M12_Human0.58206020
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57800485
110* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.57268372
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.57037028
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.52445785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.19839276
2MP0001835_abnormal_antigen_presentation3.88951826
3MP0003763_abnormal_thymus_physiology3.83853773
4MP0009785_altered_susceptibility_to3.66445606
5MP0000685_abnormal_immune_system3.49079304
6MP0005000_abnormal_immune_tolerance3.36833157
7MP0006082_CNS_inflammation3.26062646
8MP0005387_immune_system_phenotype3.24967559
9MP0001790_abnormal_immune_system3.24967559
10MP0001800_abnormal_humoral_immune3.18415669
11MP0003436_decreased_susceptibility_to3.04101134
12MP0002723_abnormal_immune_serum2.94529717
13MP0003303_peritoneal_inflammation2.94072726
14MP0002452_abnormal_antigen_presenting2.86661122
15MP0005025_abnormal_response_to2.80662004
16MP0002148_abnormal_hypersensitivity_rea2.79500531
17* MP0001819_abnormal_immune_cell2.75040420
18* MP0002420_abnormal_adaptive_immunity2.74650602
19MP0002405_respiratory_system_inflammati2.64263732
20MP0002419_abnormal_innate_immunity2.60936772
21MP0003724_increased_susceptibility_to2.58871121
22MP0009333_abnormal_splenocyte_physiolog2.37809608
23* MP0002398_abnormal_bone_marrow2.37501992
24MP0002166_altered_tumor_susceptibility2.35998523
25MP0004510_myositis2.29655528
26* MP0000716_abnormal_immune_system2.23676551
27MP0004947_skin_inflammation2.20016584
28MP0010155_abnormal_intestine_physiology2.17752934
29MP0002006_tumorigenesis2.07867693
30MP0003300_gastrointestinal_ulcer2.07464558
31MP0001853_heart_inflammation1.98812102
32* MP0002722_abnormal_immune_system1.93552857
33MP0001845_abnormal_inflammatory_respons1.93280543
34* MP0000689_abnormal_spleen_morphology1.91344310
35MP0000858_altered_metastatic_potential1.88558703
36MP0005464_abnormal_platelet_physiology1.88489830
37* MP0000703_abnormal_thymus_morphology1.82914654
38MP0001873_stomach_inflammation1.79671160
39* MP0002429_abnormal_blood_cell1.78338213
40MP0002933_joint_inflammation1.74390332
41MP0003448_altered_tumor_morphology1.71170298
42MP0005310_abnormal_salivary_gland1.67875231
43MP0001533_abnormal_skeleton_physiology1.57685470
44MP0003866_abnormal_defecation1.57564871
45MP0002138_abnormal_hepatobiliary_system1.52993636
46MP0002998_abnormal_bone_remodeling1.43866877
47MP0008469_abnormal_protein_level1.35381886
48MP0004381_abnormal_hair_follicle1.33290131
49MP0002396_abnormal_hematopoietic_system1.33161938
50MP0001851_eye_inflammation1.28793668
51MP0005058_abnormal_lysosome_morphology1.26928100
52MP0005397_hematopoietic_system_phenotyp1.21634886
53MP0001545_abnormal_hematopoietic_system1.21634886
54MP0009764_decreased_sensitivity_to1.21216143
55MP0003172_abnormal_lysosome_physiology1.08318921
56MP0009278_abnormal_bone_marrow1.07154761
57MP0000465_gastrointestinal_hemorrhage1.05504207
58MP0004808_abnormal_hematopoietic_stem1.04480740
59MP0004883_abnormal_blood_vessel1.02697561
60MP0008260_abnormal_autophagy0.99932817
61MP0005451_abnormal_body_composition0.98694287
62MP0000490_abnormal_crypts_of0.96822935
63MP0005075_abnormal_melanosome_morpholog0.95282948
64MP0005166_decreased_susceptibility_to0.94587713
65MP0003045_fibrosis0.90493354
66MP0002009_preneoplasia0.90281929
67MP0002019_abnormal_tumor_incidence0.88549246
68MP0002277_abnormal_respiratory_mucosa0.87042098
69MP0000343_altered_response_to0.86620742
70MP0005076_abnormal_cell_differentiation0.86062052
71MP0009763_increased_sensitivity_to0.86016585
72MP0005164_abnormal_response_to0.85788100
73MP0003690_abnormal_glial_cell0.82592801
74MP0000569_abnormal_digit_pigmentation0.81646769
75MP0009840_abnormal_foam_cell0.81594646
76MP0004130_abnormal_muscle_cell0.78889374
77MP0003453_abnormal_keratinocyte_physiol0.76973007
78MP0002254_reproductive_system_inflammat0.74956782
79MP0005167_abnormal_blood-brain_barrier0.73249672
80MP0006054_spinal_hemorrhage0.73058340
81MP0003075_altered_response_to0.72151164
82MP0003828_pulmonary_edema0.71935858
83MP0000249_abnormal_blood_vessel0.70859627
84MP0001348_abnormal_lacrimal_gland0.69691408
85MP0010352_gastrointestinal_tract_polyps0.69034122
86MP0002332_abnormal_exercise_endurance0.68831270
87MP0002136_abnormal_kidney_physiology0.66796142
88MP0001881_abnormal_mammary_gland0.65434442
89MP0003795_abnormal_bone_structure0.64676075
90MP0002132_abnormal_respiratory_system0.63155791
91MP0000371_diluted_coat_color0.62673720
92MP0008004_abnormal_stomach_pH0.61360019
93MP0008057_abnormal_DNA_replication0.61343621
94MP0000604_amyloidosis0.61335948
95MP0005390_skeleton_phenotype0.60916182
96MP0005174_abnormal_tail_pigmentation0.60643552
97MP0001986_abnormal_taste_sensitivity0.60446809
98MP0001501_abnormal_sleep_pattern0.58640451
99MP0001663_abnormal_digestive_system0.58044980
100MP0000015_abnormal_ear_pigmentation0.57718643
101MP0003091_abnormal_cell_migration0.57412563
102MP0005023_abnormal_wound_healing0.54582907
103MP0010307_abnormal_tumor_latency0.53712155
104MP0009765_abnormal_xenobiotic_induced0.53307431
105MP0001919_abnormal_reproductive_system0.52703308
106MP0000609_abnormal_liver_physiology0.52409390
107MP0001243_abnormal_dermal_layer0.50984949
108MP0003183_abnormal_peptide_metabolism0.50127253
109MP0003656_abnormal_erythrocyte_physiolo0.49643361
110MP0002693_abnormal_pancreas_physiology0.48850259
111MP0008874_decreased_physiological_sensi0.48449983
112MP0000920_abnormal_myelination0.48193823
113MP0003191_abnormal_cellular_cholesterol0.45700724
114MP0000627_abnormal_mammary_gland0.45553012
115MP0001191_abnormal_skin_condition0.44277099
116MP0003566_abnormal_cell_adhesion0.43226557

Predicted human phenotypes

RankGene SetZ-score
1* T lymphocytopenia (HP:0005403)5.62873112
2Retrobulbar optic neuritis (HP:0100654)5.59156802
3Optic neuritis (HP:0100653)5.59156802
4* Abnormality of T cell number (HP:0011839)5.54489634
5Myositis (HP:0100614)5.43383376
6Orchitis (HP:0100796)5.19981341
7Eczematoid dermatitis (HP:0000976)5.18838288
8Recurrent abscess formation (HP:0002722)5.03215604
9Stomatitis (HP:0010280)4.72463668
10Elevated erythrocyte sedimentation rate (HP:0003565)4.59853492
11Recurrent fungal infections (HP:0002841)4.56050147
12Recurrent bacterial skin infections (HP:0005406)4.38734119
13Mediastinal lymphadenopathy (HP:0100721)4.20594648
14Pulmonary infiltrates (HP:0002113)3.95270956
15Recurrent bronchitis (HP:0002837)3.93716192
16Recurrent viral infections (HP:0004429)3.92892780
17Autoimmune thrombocytopenia (HP:0001973)3.91881382
18Vasculitis (HP:0002633)3.91723138
19Keratoconjunctivitis sicca (HP:0001097)3.87482172
20Obstructive lung disease (HP:0006536)3.87407422
21Chronic obstructive pulmonary disease (HP:0006510)3.87407422
22* Abnormality of T cells (HP:0002843)3.85068495
23Hemoptysis (HP:0002105)3.79058323
24Meningitis (HP:0001287)3.64081853
25Recurrent gram-negative bacterial infections (HP:0005420)3.60557807
26Recurrent cutaneous fungal infections (HP:0011370)3.57959390
27Chronic mucocutaneous candidiasis (HP:0002728)3.57959390
28Gastrointestinal infarctions (HP:0005244)3.52238813
29Keratoconjunctivitis (HP:0001096)3.51260243
30IgG deficiency (HP:0004315)3.45929933
31Arterial thrombosis (HP:0004420)3.44122585
32* Combined immunodeficiency (HP:0005387)3.38237582
33Abnormality of the prostate (HP:0008775)3.38229324
34Recurrent skin infections (HP:0001581)3.36773376
35IgM deficiency (HP:0002850)3.36095313
36Abnormality of macrophages (HP:0004311)3.33579305
37* Severe combined immunodeficiency (HP:0004430)3.27081029
38Nasal polyposis (HP:0100582)3.21662822
39Pustule (HP:0200039)3.12563440
40Chronic otitis media (HP:0000389)3.09945748
41Gingivitis (HP:0000230)3.04399340
42Agammaglobulinemia (HP:0004432)2.93851974
43Increased IgM level (HP:0003496)2.91830944
44Gangrene (HP:0100758)2.91566594
45* Leukocytosis (HP:0001974)2.91495295
46Vacuolated lymphocytes (HP:0001922)2.90989668
47Joint swelling (HP:0001386)2.86819856
48Pulmonary embolism (HP:0002204)2.86619536
49Lymphopenia (HP:0001888)2.86339722
50Abnormality of B cell number (HP:0010975)2.84299397
51B lymphocytopenia (HP:0010976)2.84299397
52Chronic diarrhea (HP:0002028)2.82773993
53Eosinophilia (HP:0001880)2.80135893
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.78817712
55* Thyroiditis (HP:0100646)2.73730541
56Encephalitis (HP:0002383)2.70637559
57Cellulitis (HP:0100658)2.68500045
58* Abnormality of eosinophils (HP:0001879)2.68203958
59Abnormality of the nasal mucosa (HP:0000433)2.65919552
60Autoimmune hemolytic anemia (HP:0001890)2.64944930
61Increased IgE level (HP:0003212)2.59112893
62Panhypogammaglobulinemia (HP:0003139)2.58771611
63Anorexia (HP:0002039)2.57395791
64Hematochezia (HP:0002573)2.52396143
65Chest pain (HP:0100749)2.50385197
66Verrucae (HP:0200043)2.48181227
67Papilloma (HP:0012740)2.48181227
68Stomach cancer (HP:0012126)2.47945553
69Periodontitis (HP:0000704)2.46877185
70Epistaxis (HP:0000421)2.46561761
71Abnormality of T cell physiology (HP:0011840)2.45919328
72Spontaneous hematomas (HP:0007420)2.44610416
73Hypoplasia of the thymus (HP:0000778)2.43559740
74Abnormality of the fingertips (HP:0001211)2.42192659
75Osteomyelitis (HP:0002754)2.39845473
76Colitis (HP:0002583)2.39068542
77Abnormality of the pleura (HP:0002103)2.36853357
78Slow saccadic eye movements (HP:0000514)2.36227824
79Prolonged bleeding time (HP:0003010)2.35156851
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34199892
81Recurrent sinusitis (HP:0011108)2.33047450
82Granulocytopenia (HP:0001913)2.32817318
83IgA deficiency (HP:0002720)2.32587842
84Prostate neoplasm (HP:0100787)2.32142397
85Polyneuropathy (HP:0001271)2.31849669
86Glomerulopathy (HP:0100820)2.31599543
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.30615843
88Abnormality of the pericardium (HP:0001697)2.30337960
89Urticaria (HP:0001025)2.27140764
90Increased cerebral lipofuscin (HP:0011813)2.25189592
91Petechiae (HP:0000967)2.15467887
92Arthralgia (HP:0002829)2.14250769
93Gingival bleeding (HP:0000225)2.13556925
94Hypergammaglobulinemia (HP:0010702)2.11550407
95Gastrointestinal stroma tumor (HP:0100723)2.11341616
96Abnormality of the endocardium (HP:0004306)2.10136638
97Papilledema (HP:0001085)2.09387541
98Recurrent pneumonia (HP:0006532)2.06680300
99Inflammation of the large intestine (HP:0002037)2.06483940
100Bronchitis (HP:0012387)2.05063949
101Vertigo (HP:0002321)2.04921038
102Abnormality of glycolipid metabolism (HP:0010969)2.03080951
103Abnormality of liposaccharide metabolism (HP:0010968)2.03080951
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.03080951
105Myocardial infarction (HP:0001658)2.02839742
106Increased density of long bones (HP:0006392)2.02830510
107Keratitis (HP:0000491)2.01525769
108Ureteral stenosis (HP:0000071)1.99307384
109Cheilitis (HP:0100825)1.99179458
110Restrictive lung disease (HP:0002091)1.97160002
111Dysostosis multiplex (HP:0000943)1.96315510
112Gastrointestinal inflammation (HP:0004386)1.96295243
113Loss of speech (HP:0002371)1.95938250
114Hypochromic anemia (HP:0001931)1.92535731
115Alveolar cell carcinoma (HP:0006519)1.91263294
116Neoplasm of the tracheobronchial system (HP:0100552)1.89402725
117Episodic fever (HP:0001954)1.88301649
118Premature loss of primary teeth (HP:0006323)1.86946131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.88229394
2MAP4K14.21848997
3MAP3K144.09610671
4ITK3.02816737
5IKBKE2.91060572
6TBK12.66503248
7NLK2.65687301
8JAK32.62984855
9TYK22.41666634
10MST42.38665784
11ZAP702.31498392
12GRK62.16593035
13BLK2.14277199
14PRPF4B2.08615759
15RIPK42.03995616
16IRAK42.00033706
17IKBKB1.98360183
18IRAK31.92923702
19* JAK11.90398123
20MAP3K131.86428906
21STK101.86401362
22TEC1.81508116
23CSK1.78936448
24SYK1.70186975
25CAMKK21.68720984
26LCK1.65779358
27CHUK1.64486758
28MAP3K101.58208305
29FGFR41.52822615
30HCK1.52421947
31BTK1.50512176
32FGFR31.43066248
33TAOK31.42348478
34PIM11.29289083
35GRK71.29172390
36STK41.24401264
37KIT1.24286938
38NME21.16166596
39JAK21.08859122
40PRKCQ1.08124722
41MATK1.03359449
42LYN1.02953337
43CAMKK11.02772476
44MARK30.94277579
45MAP3K30.93457046
46SIK20.89423198
47CLK10.88165613
48MAP2K20.86702601
49TESK20.86330340
50RPS6KA40.83705664
51TYRO30.83339551
52ERN10.83158245
53NEK90.82705920
54TGFBR20.79624823
55PBK0.78822697
56MAP3K110.78719352
57CDC42BPA0.74387683
58MAP3K10.73995605
59KSR20.72736590
60TAOK10.72170513
61CDK120.69068090
62TAOK20.67238144
63PASK0.64701806
64TRPM70.62907817
65LRRK20.60674505
66CSF1R0.59033010
67EPHB10.59007835
68STK240.55984598
69SIK30.55905029
70FES0.55876051
71MELK0.55074441
72PRKCH0.54727944
73IRAK10.54504373
74MARK20.53474417
75NEK60.53138460
76PIK3CG0.52693460
77CDK60.52384534
78TLK10.51185540
79STK380.49791928
80RAF10.49471806
81BMX0.49227154
82IRAK20.48544530
83PDGFRB0.48483435
84ACVR1B0.47403807
85ABL10.46823266
86PRKCD0.45874078
87KDR0.45743706
88MAP3K70.45132531
89CDK40.44689284
90PKN20.43221270
91SGK30.42699131
92NUAK10.41845714
93SGK20.40365984
94FYN0.39691550
95MAPKAPK20.38028585
96EPHA30.37733016
97HIPK20.37501328
98PDK10.37323860
99IGF1R0.36208801
100MOS0.36031016
101MAPK70.35532375
102CDK90.35481288
103MAP2K60.33906995
104INSR0.32801828
105RPS6KC10.32175233
106RPS6KL10.32175233
107YES10.31733019
108PIM20.31345642
109TNK20.31096108
110BRD40.31045809
111PTK60.30511402
112KSR10.28557183
113TTN0.26187583
114EIF2AK20.25805642
115TRIB30.25647825
116MAP2K30.23860992
117DMPK0.22584135
118EGFR0.21867466
119MAPK30.21019553
120EEF2K0.20610621
121VRK10.19949704
122MAPK120.18552868
123RPS6KA60.18157533
124BMPR20.17562545
125MAPK40.17312082
126SRC0.16897733
127FLT30.16677629
128MAPK110.15601741
129ADRBK20.15368155
130MAP3K50.14878724
131FGR0.12468672

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053403.95361739
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.24340169
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.05533355
4Allograft rejection_Homo sapiens_hsa053302.99079873
5T cell receptor signaling pathway_Homo sapiens_hsa046602.96030652
6Graft-versus-host disease_Homo sapiens_hsa053322.94549402
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.90116503
8Leishmaniasis_Homo sapiens_hsa051402.78909678
9Measles_Homo sapiens_hsa051622.71934388
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.63904512
11Osteoclast differentiation_Homo sapiens_hsa043802.59726071
12Autoimmune thyroid disease_Homo sapiens_hsa053202.19835615
13Antigen processing and presentation_Homo sapiens_hsa046122.17335018
14B cell receptor signaling pathway_Homo sapiens_hsa046622.10355776
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94023204
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93336278
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90940978
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84691095
19* Jak-STAT signaling pathway_Homo sapiens_hsa046301.80115384
20* Hematopoietic cell lineage_Homo sapiens_hsa046401.72568963
21Staphylococcus aureus infection_Homo sapiens_hsa051501.69380723
22Asthma_Homo sapiens_hsa053101.68315837
23TNF signaling pathway_Homo sapiens_hsa046681.63297834
24Chemokine signaling pathway_Homo sapiens_hsa040621.60376672
25Toxoplasmosis_Homo sapiens_hsa051451.59811958
26Rheumatoid arthritis_Homo sapiens_hsa053231.57761108
27Legionellosis_Homo sapiens_hsa051341.54569183
28Tuberculosis_Homo sapiens_hsa051521.53665911
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50595777
30Herpes simplex infection_Homo sapiens_hsa051681.50171971
31Viral myocarditis_Homo sapiens_hsa054161.48965035
32* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48946528
33Malaria_Homo sapiens_hsa051441.48903849
34Influenza A_Homo sapiens_hsa051641.44396095
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42941097
36Apoptosis_Homo sapiens_hsa042101.37744893
37Type I diabetes mellitus_Homo sapiens_hsa049401.24249291
38Acute myeloid leukemia_Homo sapiens_hsa052211.22766949
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22627890
40Hepatitis B_Homo sapiens_hsa051611.22316287
41Pertussis_Homo sapiens_hsa051331.20005821
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.13232604
43Shigellosis_Homo sapiens_hsa051311.08595978
44Lysosome_Homo sapiens_hsa041421.06903708
45Salmonella infection_Homo sapiens_hsa051321.00885184
46Hepatitis C_Homo sapiens_hsa051600.95655965
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90363650
48Prolactin signaling pathway_Homo sapiens_hsa049170.87331807
49Pancreatic cancer_Homo sapiens_hsa052120.86292859
50Chronic myeloid leukemia_Homo sapiens_hsa052200.86018051
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85277022
52Platelet activation_Homo sapiens_hsa046110.84338476
53Epstein-Barr virus infection_Homo sapiens_hsa051690.80583522
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77243614
55African trypanosomiasis_Homo sapiens_hsa051430.73197593
56HTLV-I infection_Homo sapiens_hsa051660.73184276
57Phagosome_Homo sapiens_hsa041450.67196461
58Dorso-ventral axis formation_Homo sapiens_hsa043200.65892953
59Other glycan degradation_Homo sapiens_hsa005110.64156313
60Viral carcinogenesis_Homo sapiens_hsa052030.63399219
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.62001348
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60299808
63Colorectal cancer_Homo sapiens_hsa052100.59582457
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58294035
65VEGF signaling pathway_Homo sapiens_hsa043700.57550865
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56220366
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55882571
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55661720
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53312666
70Notch signaling pathway_Homo sapiens_hsa043300.50898491
71* FoxO signaling pathway_Homo sapiens_hsa040680.49019900
72Non-small cell lung cancer_Homo sapiens_hsa052230.47506599
73p53 signaling pathway_Homo sapiens_hsa041150.46498125
74Small cell lung cancer_Homo sapiens_hsa052220.46434270
75Type II diabetes mellitus_Homo sapiens_hsa049300.44932455
76Endocytosis_Homo sapiens_hsa041440.42845860
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41050729
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40814105
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.40611200
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39959004
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.39087475
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37328498
83Amoebiasis_Homo sapiens_hsa051460.37326849
84Prostate cancer_Homo sapiens_hsa052150.36408933
85GnRH signaling pathway_Homo sapiens_hsa049120.30739844
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29632185
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29315149
88Ras signaling pathway_Homo sapiens_hsa040140.29185640
89MAPK signaling pathway_Homo sapiens_hsa040100.28911153
90Regulation of autophagy_Homo sapiens_hsa041400.28871984
91Thyroid cancer_Homo sapiens_hsa052160.28792524
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27523190
93HIF-1 signaling pathway_Homo sapiens_hsa040660.27308740
94Insulin resistance_Homo sapiens_hsa049310.27259467
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.27084536
96ErbB signaling pathway_Homo sapiens_hsa040120.26541645
97Endometrial cancer_Homo sapiens_hsa052130.26207271
98Circadian rhythm_Homo sapiens_hsa047100.25317669
99Inositol phosphate metabolism_Homo sapiens_hsa005620.24970559
100Adherens junction_Homo sapiens_hsa045200.23991401
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23685773
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22556990
103Renal cell carcinoma_Homo sapiens_hsa052110.21886490
104MicroRNAs in cancer_Homo sapiens_hsa052060.19321510
105Collecting duct acid secretion_Homo sapiens_hsa049660.17932755
106Choline metabolism in cancer_Homo sapiens_hsa052310.17580214
107mTOR signaling pathway_Homo sapiens_hsa041500.17331601
108Non-homologous end-joining_Homo sapiens_hsa034500.16635027
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.16475267
110Rap1 signaling pathway_Homo sapiens_hsa040150.16004514
111Proteoglycans in cancer_Homo sapiens_hsa052050.12554436
112Pathways in cancer_Homo sapiens_hsa052000.11984963

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »