IL9R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)7.39526862
2negative regulation of erythrocyte differentiation (GO:0045647)7.14678966
3B cell receptor signaling pathway (GO:0050853)7.14073547
4regulation of B cell receptor signaling pathway (GO:0050855)6.35131635
5positive regulation of gamma-delta T cell activation (GO:0046645)6.34037477
6NIK/NF-kappaB signaling (GO:0038061)5.90696595
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.62206235
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.62206235
9B cell proliferation (GO:0042100)5.35320764
10regulation of B cell differentiation (GO:0045577)5.27958575
11positive thymic T cell selection (GO:0045059)5.15572943
12mature B cell differentiation (GO:0002335)5.03877565
13negative regulation of B cell proliferation (GO:0030889)4.78520892
14regulation of interferon-beta biosynthetic process (GO:0045357)4.72673558
15positive regulation of B cell differentiation (GO:0045579)4.62682983
16regulation of B cell proliferation (GO:0030888)4.59178485
17regulation of gamma-delta T cell differentiation (GO:0045586)4.58179158
18negative thymic T cell selection (GO:0045060)4.57625174
19mucosal-associated lymphoid tissue development (GO:0048537)4.49967928
20Peyers patch development (GO:0048541)4.49967928
21tolerance induction (GO:0002507)4.45645733
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.44621691
23regulation of gamma-delta T cell activation (GO:0046643)4.40993698
24Arp2/3 complex-mediated actin nucleation (GO:0034314)4.39951490
25negative T cell selection (GO:0043383)4.39744979
26negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.35865895
27thymic T cell selection (GO:0045061)4.35660928
28antigen receptor-mediated signaling pathway (GO:0050851)4.25143623
29regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.22297824
30cellular response to zinc ion (GO:0071294)4.14259044
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13542531
32positive T cell selection (GO:0043368)4.12135398
33T cell selection (GO:0045058)4.09121539
34positive regulation of B cell proliferation (GO:0030890)4.03947059
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.81401693
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.79694159
37positive regulation of interleukin-2 production (GO:0032743)3.79241173
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.78005363
39response to muramyl dipeptide (GO:0032495)3.69550104
40T cell migration (GO:0072678)3.69357599
41negative regulation of cell killing (GO:0031342)3.63579473
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63579473
43regulation of alpha-beta T cell proliferation (GO:0046640)3.62773330
44B cell homeostasis (GO:0001782)3.61000306
45negative regulation of calcium ion transport into cytosol (GO:0010523)3.57533425
46immune response-activating cell surface receptor signaling pathway (GO:0002429)3.56486012
47regulation of B cell apoptotic process (GO:0002902)3.56201785
48lymphocyte homeostasis (GO:0002260)3.54510966
49positive regulation of immunoglobulin production (GO:0002639)3.54313027
50positive regulation of B cell activation (GO:0050871)3.53596623
51T cell costimulation (GO:0031295)3.52710948
52lymphocyte costimulation (GO:0031294)3.52693610
53regulation of B cell activation (GO:0050864)3.51342219
54regulation of erythrocyte differentiation (GO:0045646)3.51235013
55positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.50355616
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50044702
57* response to interleukin-15 (GO:0070672)3.47273642
58lymph node development (GO:0048535)3.46316964
59positive regulation of antigen processing and presentation (GO:0002579)3.45932407
60positive regulation of granulocyte differentiation (GO:0030854)3.44024668
61definitive hemopoiesis (GO:0060216)3.43642206
62B cell activation (GO:0042113)3.43575843
63actin nucleation (GO:0045010)3.41229083
64regulation of MHC class I biosynthetic process (GO:0045343)3.40797354
65regulation of interferon-alpha production (GO:0032647)3.40526239
66T cell homeostasis (GO:0043029)3.40030350
67neutrophil activation (GO:0042119)3.39469219
68defense response to protozoan (GO:0042832)3.37675595
69lymphocyte proliferation (GO:0046651)3.34136709
70mononuclear cell proliferation (GO:0032943)3.32303824
71JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30844249
72regulation of T cell tolerance induction (GO:0002664)3.30668782
73negative regulation of histone methylation (GO:0031061)3.30597131
74regulation of regulatory T cell differentiation (GO:0045589)3.29008863
75megakaryocyte development (GO:0035855)3.27773341
76myeloid dendritic cell activation (GO:0001773)3.25208396
77mature B cell differentiation involved in immune response (GO:0002313)3.24699746
78interferon-gamma-mediated signaling pathway (GO:0060333)3.24454052
79regulation of T cell receptor signaling pathway (GO:0050856)3.23530841
80regulation of histone H3-K27 methylation (GO:0061085)3.22452826
81myeloid dendritic cell differentiation (GO:0043011)3.21276598
82negative regulation of T cell mediated immunity (GO:0002710)3.21214123
83T cell receptor signaling pathway (GO:0050852)3.16303917
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16176381
85positive regulation of interferon-alpha production (GO:0032727)3.15729610
86mast cell activation (GO:0045576)3.12679209
87leukocyte aggregation (GO:0070486)3.12249292
88T-helper cell differentiation (GO:0042093)3.09694254
89CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.09694254
90histone H3-K36 demethylation (GO:0070544)3.09240823
91regulation of MHC class II biosynthetic process (GO:0045346)3.08210202
92natural killer cell differentiation (GO:0001779)3.08076320
93regulation of immunoglobulin production (GO:0002637)3.06873284
94B cell differentiation (GO:0030183)3.06868897
95leukocyte homeostasis (GO:0001776)3.05924316
96granulocyte activation (GO:0036230)3.03745843
97regulation of interleukin-2 biosynthetic process (GO:0045076)3.01815864
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01376040
99germinal center formation (GO:0002467)3.01270673
100activation of MAPKKK activity (GO:0000185)2.98872109
101leukocyte proliferation (GO:0070661)2.97595539
102positive regulation of cytokine biosynthetic process (GO:0042108)2.96661872
103immunoglobulin mediated immune response (GO:0016064)2.96365822
104cellular response to interleukin-4 (GO:0071353)2.95826509
105positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93879789
106mast cell activation involved in immune response (GO:0002279)2.93859994
107mast cell degranulation (GO:0043303)2.93859994
108V(D)J recombination (GO:0033151)2.92275070
109negative regulation of alpha-beta T cell activation (GO:0046636)2.91846184
110regulation of antigen processing and presentation (GO:0002577)2.90081672
111positive regulation of Rap GTPase activity (GO:0032854)2.89292762
112response to protozoan (GO:0001562)2.88746343
113I-kappaB phosphorylation (GO:0007252)2.88109206
114positive regulation of interleukin-12 production (GO:0032735)2.88050988
115* cellular response to interleukin-15 (GO:0071350)2.87077487
116negative regulation of bone resorption (GO:0045779)2.87018510
117positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84026873
118positive regulation of production of molecular mediator of immune response (GO:0002702)2.82781700
119regulation of interleukin-12 production (GO:0032655)2.82533634
120negative regulation of B cell activation (GO:0050869)2.82203023
121monoubiquitinated protein deubiquitination (GO:0035520)2.81326209
122positive regulation of histone deacetylation (GO:0031065)2.79187271
123regulation of granulocyte differentiation (GO:0030852)2.78589296
124negative regulation of B cell apoptotic process (GO:0002903)2.78528968
125positive regulation of natural killer cell differentiation (GO:0032825)2.76721124
126response to interleukin-4 (GO:0070670)2.72562519
127alpha-beta T cell differentiation involved in immune response (GO:0002293)2.72050710
128alpha-beta T cell activation involved in immune response (GO:0002287)2.72050710
129T cell differentiation involved in immune response (GO:0002292)2.72050710
130leukocyte degranulation (GO:0043299)2.70535492
1313-UTR-mediated mRNA stabilization (GO:0070935)2.69449035
132positive regulation of interleukin-4 production (GO:0032753)2.67337208
133positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.66992443
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65246241
135regulation of interleukin-4 production (GO:0032673)2.63258532
136positive regulation of T cell differentiation (GO:0045582)2.59804897
137regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.59253173
138DNA unwinding involved in DNA replication (GO:0006268)2.57316194
139positive regulation of alpha-beta T cell differentiation (GO:0046638)2.56387322
140positive regulation of alpha-beta T cell activation (GO:0046635)2.56254394
141negative regulation of phagocytosis (GO:0050765)2.54055973
142positive regulation of erythrocyte differentiation (GO:0045648)2.53382595
143regulation of hypersensitivity (GO:0002883)2.53224649
144T cell differentiation (GO:0030217)2.53193904
145alpha-beta T cell activation (GO:0046631)2.52417023
146activated T cell proliferation (GO:0050798)2.51423874
147regulation of histone H3-K9 methylation (GO:0051570)2.51201245
148regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.50245367
149alpha-beta T cell differentiation (GO:0046632)2.49090147
150dosage compensation (GO:0007549)2.48092484
151positive regulation of lymphocyte differentiation (GO:0045621)2.47040912
152CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.46689365
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.46652700
154regulation of natural killer cell mediated immunity (GO:0002715)2.46124812
155regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46124812
156regulation of alpha-beta T cell activation (GO:0046634)2.44785855
157regulation of alpha-beta T cell differentiation (GO:0046637)2.44478114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.58337039
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.88130720
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.87125473
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.33491788
5MYC_22102868_ChIP-Seq_BL_Human4.21037713
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.00569371
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.89673963
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45238165
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.27578253
10RUNX_20019798_ChIP-Seq_JUKART_Human3.23373430
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.13650041
12VDR_21846776_ChIP-Seq_THP-1_Human3.11447162
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.05662309
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.03071237
15MYB_26560356_Chip-Seq_TH2_Human2.81944015
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.73948745
17MAF_26560356_Chip-Seq_TH1_Human2.73613135
18MYB_26560356_Chip-Seq_TH1_Human2.64349104
19E2F7_22180533_ChIP-Seq_HELA_Human2.57234964
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54460597
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50793102
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45585229
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44879339
24SCL_19346495_ChIP-Seq_HPC-7_Human2.36224058
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35932290
26UTX_26944678_Chip-Seq_JUKART_Human2.29228948
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27382019
28GATA1_22025678_ChIP-Seq_K562_Human2.25635033
29VDR_24763502_ChIP-Seq_THP-1_Human2.22347510
30TCF7_22412390_ChIP-Seq_EML_Mouse2.21417342
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.16907972
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08316889
33SPI1_23547873_ChIP-Seq_NB4_Human2.04404151
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04264388
35CIITA_25753668_ChIP-Seq_RAJI_Human2.04127857
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99648392
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88189779
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.85187055
39KDM2B_26808549_Chip-Seq_DND41_Human1.83543635
40MAF_26560356_Chip-Seq_TH2_Human1.77723988
41GATA3_27048872_Chip-Seq_THYMUS_Human1.75816150
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74476844
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71972937
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70585265
45* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65506811
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64984136
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64215199
48SPI1_23127762_ChIP-Seq_K562_Human1.61437288
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52876418
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.49829815
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48822991
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.47873712
53* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46135442
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46064242
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44396097
56* GATA1_19941827_ChIP-Seq_MEL_Mouse1.43295338
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40665913
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37386055
59PU_27001747_Chip-Seq_BMDM_Mouse1.36232863
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33124018
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31013343
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30241239
63* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27824351
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.27737361
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27643836
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26192981
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23230643
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.21128969
69* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20312440
70* GATA3_26560356_Chip-Seq_TH2_Human1.19367133
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17156420
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15646400
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12981215
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.10878227
75VDR_24787735_ChIP-Seq_THP-1_Human1.07978691
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07933861
77* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07331397
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06737261
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06052553
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05040165
81GATA1_19941826_ChIP-Seq_K562_Human1.04720177
82* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04505362
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.02040236
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.99855204
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98529538
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.95881901
87* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95498881
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94063078
89GATA2_19941826_ChIP-Seq_K562_Human0.93694949
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92083571
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92021337
92LXR_22292898_ChIP-Seq_THP-1_Human0.91645800
93NCOR1_26117541_ChIP-Seq_K562_Human0.90594282
94SMRT_27268052_Chip-Seq_Bcells_Human0.90486474
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89240424
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87958880
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87366520
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87291390
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87005725
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86685247
101* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86175543
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86159706
103TFEB_21752829_ChIP-Seq_HELA_Human0.85405119
104SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81291247
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80070394
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79232308
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79155226
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78969258
109* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75986356
110GATA3_26560356_Chip-Seq_TH1_Human0.74093036
111HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71884147
112E2F4_17652178_ChIP-ChIP_JURKAT_Human0.71349605
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71171754
114P300_27268052_Chip-Seq_Bcells_Human0.70671913
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70157806
116* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64853916
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.64802012
118KDM5A_27292631_Chip-Seq_BREAST_Human0.64703673
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.63785265
120FOXP3_21729870_ChIP-Seq_TREG_Human0.62117349
121VDR_23849224_ChIP-Seq_CD4+_Human0.61891569
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61815615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.51410889
2MP0005387_immune_system_phenotype4.74527119
3MP0001790_abnormal_immune_system4.74527119
4MP0001800_abnormal_humoral_immune4.48136217
5MP0000685_abnormal_immune_system3.97030220
6MP0002452_abnormal_antigen_presenting3.38883925
7MP0005671_abnormal_response_to3.30406530
8* MP0005000_abnormal_immune_tolerance3.24942064
9MP0003303_peritoneal_inflammation3.24574149
10MP0001873_stomach_inflammation3.24463746
11MP0002723_abnormal_immune_serum3.01462135
12* MP0002420_abnormal_adaptive_immunity2.89507868
13MP0002398_abnormal_bone_marrow2.82457795
14MP0003763_abnormal_thymus_physiology2.81223074
15* MP0001819_abnormal_immune_cell2.80587515
16MP0004510_myositis2.79723453
17* MP0000716_abnormal_immune_system2.51779868
18MP0000689_abnormal_spleen_morphology2.31278529
19MP0003300_gastrointestinal_ulcer2.29306691
20MP0005310_abnormal_salivary_gland2.27160576
21MP0002166_altered_tumor_susceptibility2.24779880
22MP0004381_abnormal_hair_follicle2.15066445
23MP0005025_abnormal_response_to2.14368298
24MP0002722_abnormal_immune_system2.09053020
25* MP0002429_abnormal_blood_cell2.07512064
26MP0002396_abnormal_hematopoietic_system2.02957937
27MP0002254_reproductive_system_inflammat1.99785159
28MP0002009_preneoplasia1.99284387
29MP0002138_abnormal_hepatobiliary_system1.93058851
30MP0002148_abnormal_hypersensitivity_rea1.92754330
31MP0002419_abnormal_innate_immunity1.92222268
32MP0002405_respiratory_system_inflammati1.89970191
33MP0003436_decreased_susceptibility_to1.79225031
34MP0001853_heart_inflammation1.77892635
35MP0009785_altered_susceptibility_to1.75138524
36MP0010155_abnormal_intestine_physiology1.68068350
37MP0000703_abnormal_thymus_morphology1.67623023
38MP0009333_abnormal_splenocyte_physiolog1.67593341
39MP0002006_tumorigenesis1.66120614
40MP0001845_abnormal_inflammatory_respons1.65334790
41MP0004808_abnormal_hematopoietic_stem1.59332826
42MP0004947_skin_inflammation1.58842707
43MP0008057_abnormal_DNA_replication1.54887290
44MP0000569_abnormal_digit_pigmentation1.40003677
45MP0005464_abnormal_platelet_physiology1.38014974
46MP0004185_abnormal_adipocyte_glucose1.36242311
47MP0003787_abnormal_imprinting1.35446054
48MP0000465_gastrointestinal_hemorrhage1.35366718
49MP0003866_abnormal_defecation1.30062408
50MP0003045_fibrosis1.28490109
51MP0003172_abnormal_lysosome_physiology1.25222285
52MP0003693_abnormal_embryo_hatching1.23747424
53MP0005174_abnormal_tail_pigmentation1.21953934
54MP0002933_joint_inflammation1.20111856
55MP0001851_eye_inflammation1.14720403
56MP0002877_abnormal_melanocyte_morpholog1.00173416
57MP0003183_abnormal_peptide_metabolism0.99276933
58MP0003091_abnormal_cell_migration0.98860632
59MP0006082_CNS_inflammation0.97606056
60MP0008469_abnormal_protein_level0.95810693
61MP0001348_abnormal_lacrimal_gland0.95242849
62MP0010352_gastrointestinal_tract_polyps0.94956304
63MP0001545_abnormal_hematopoietic_system0.92435566
64MP0005397_hematopoietic_system_phenotyp0.92435566
65MP0000516_abnormal_urinary_system0.83755742
66MP0005367_renal/urinary_system_phenotyp0.83755742
67MP0000490_abnormal_crypts_of0.83215577
68MP0002136_abnormal_kidney_physiology0.83194991
69MP0000015_abnormal_ear_pigmentation0.81752494
70MP0001663_abnormal_digestive_system0.81260559
71MP0002019_abnormal_tumor_incidence0.79933004
72MP0009765_abnormal_xenobiotic_induced0.79882097
73MP0004957_abnormal_blastocyst_morpholog0.78093186
74MP0010234_abnormal_vibrissa_follicle0.77664630
75MP0001730_embryonic_growth_arrest0.76797660
76MP0005451_abnormal_body_composition0.74850150
77MP0004264_abnormal_extraembryonic_tissu0.74710612
78MP0005666_abnormal_adipose_tissue0.73942879
79MP0000609_abnormal_liver_physiology0.73828940
80MP0003077_abnormal_cell_cycle0.73625225
81MP0002277_abnormal_respiratory_mucosa0.73537939
82MP0008874_decreased_physiological_sensi0.72815688
83MP0003453_abnormal_keratinocyte_physiol0.72780057
84MP0008007_abnormal_cellular_replicative0.72353547
85MP0009764_decreased_sensitivity_to0.72069121
86MP0009931_abnormal_skin_appearance0.71103612
87MP0009763_increased_sensitivity_to0.69378285
88MP0003448_altered_tumor_morphology0.68783270
89MP0002095_abnormal_skin_pigmentation0.68144183
90MP0008961_abnormal_basal_metabolism0.67729196
91MP0002928_abnormal_bile_duct0.67613652
92MP0005075_abnormal_melanosome_morpholog0.66996921
93MP0005076_abnormal_cell_differentiation0.66566497
94MP0009278_abnormal_bone_marrow0.65691803
95MP0003786_premature_aging0.62170402
96MP0003646_muscle_fatigue0.61667380
97MP0009115_abnormal_fat_cell0.60932034
98MP0003221_abnormal_cardiomyocyte_apopto0.60108101
99MP0008995_early_reproductive_senescence0.59991458
100MP0001727_abnormal_embryo_implantation0.59895961
101MP0001533_abnormal_skeleton_physiology0.59519887
102MP0000858_altered_metastatic_potential0.59026123
103MP0003828_pulmonary_edema0.58279861
104MP0003656_abnormal_erythrocyte_physiolo0.57754175
105MP0008260_abnormal_autophagy0.57558127
106MP0002132_abnormal_respiratory_system0.57205500
107MP0001879_abnormal_lymphatic_vessel0.54939138
108MP0002086_abnormal_extraembryonic_tissu0.54644213
109MP0002080_prenatal_lethality0.54096931
110MP0008877_abnormal_DNA_methylation0.53546389
111MP0000598_abnormal_liver_morphology0.53283447
112MP0005166_decreased_susceptibility_to0.52615492
113MP0001919_abnormal_reproductive_system0.52597638
114MP0000371_diluted_coat_color0.51962052
115MP0002998_abnormal_bone_remodeling0.51937500
116MP0003724_increased_susceptibility_to0.51664684
117MP0000313_abnormal_cell_death0.51519991
118MP0005621_abnormal_cell_physiology0.51512696
119MP0000767_abnormal_smooth_muscle0.50874329
120MP0003111_abnormal_nucleus_morphology0.50563513
121MP0005220_abnormal_exocrine_pancreas0.50231670
122MP0002083_premature_death0.50129966
123MP0000350_abnormal_cell_proliferation0.49125240
124MP0010094_abnormal_chromosome_stability0.47659436
125MP0010307_abnormal_tumor_latency0.45414265
126MP0000249_abnormal_blood_vessel0.44870015
127MP0001986_abnormal_taste_sensitivity0.44184631
128MP0008058_abnormal_DNA_repair0.43519664
129MP0008872_abnormal_physiological_respon0.43226394
130MP0002168_other_aberrant_phenotype0.42313811

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.65374604
2Gastrointestinal stroma tumor (HP:0100723)7.31797914
3Recurrent bronchitis (HP:0002837)5.52785743
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.39784740
5Colitis (HP:0002583)5.33000642
6Recurrent sinusitis (HP:0011108)5.27554793
7IgM deficiency (HP:0002850)5.10582174
8Panhypogammaglobulinemia (HP:0003139)5.09261907
9Recurrent viral infections (HP:0004429)5.01877423
10Inflammation of the large intestine (HP:0002037)4.94670143
11Lymphopenia (HP:0001888)4.76903740
12Emphysema (HP:0002097)4.72131440
13Gastrointestinal inflammation (HP:0004386)4.70520805
14Vasculitis (HP:0002633)4.56531200
15Abnormality of cells of the lymphoid lineage (HP:0012140)4.49724743
16Meningitis (HP:0001287)4.37573402
17Cellulitis (HP:0100658)4.35937598
18Verrucae (HP:0200043)4.19605866
19Papilloma (HP:0012740)4.19605866
20Recurrent cutaneous fungal infections (HP:0011370)4.15740254
21Chronic mucocutaneous candidiasis (HP:0002728)4.15740254
22Recurrent fungal infections (HP:0002841)4.13258863
23Chronic otitis media (HP:0000389)4.09117685
24IgA deficiency (HP:0002720)4.07513302
25Granulocytopenia (HP:0001913)4.00988344
26Chronic sinusitis (HP:0011109)3.83237966
27Restrictive lung disease (HP:0002091)3.68507403
28Chronic diarrhea (HP:0002028)3.64233308
29Abnormality of the fingertips (HP:0001211)3.62459698
30Stomatitis (HP:0010280)3.56123015
31Mediastinal lymphadenopathy (HP:0100721)3.44554974
32Recurrent abscess formation (HP:0002722)3.44319585
33Autoimmune hemolytic anemia (HP:0001890)3.36833823
34Recurrent bacterial skin infections (HP:0005406)3.33495636
35Pulmonary infiltrates (HP:0002113)3.31958642
36Acute lymphatic leukemia (HP:0006721)3.24424909
37B lymphocytopenia (HP:0010976)3.24415650
38Abnormality of B cell number (HP:0010975)3.24415650
39Increased IgE level (HP:0003212)3.19762691
40Bronchitis (HP:0012387)3.17571350
41Elevated erythrocyte sedimentation rate (HP:0003565)3.16824001
42Fatigue (HP:0012378)3.12234692
43Recurrent skin infections (HP:0001581)3.10674300
44Abnormality of T cells (HP:0002843)3.09578492
45Abnormality of T cell physiology (HP:0011840)3.06397078
46Eczematoid dermatitis (HP:0000976)3.01716749
47Recurrent otitis media (HP:0000403)2.97517147
48Obstructive lung disease (HP:0006536)2.96183109
49Chronic obstructive pulmonary disease (HP:0006510)2.96183109
50Recurrent lower respiratory tract infections (HP:0002783)2.94223328
51Increased IgM level (HP:0003496)2.94213402
52Recurrent pneumonia (HP:0006532)2.93446805
53Encephalitis (HP:0002383)2.93387684
54T lymphocytopenia (HP:0005403)2.92747887
55Leukopenia (HP:0001882)2.91673263
56Nasal polyposis (HP:0100582)2.89283351
57Lymphoma (HP:0002665)2.86588075
58Leukocytosis (HP:0001974)2.82934805
59Osteomyelitis (HP:0002754)2.81634288
60Viral hepatitis (HP:0006562)2.81274673
61Abnormality of T cell number (HP:0011839)2.80174831
62Abnormality of eosinophils (HP:0001879)2.72369995
63Thyroiditis (HP:0100646)2.66277482
64Pustule (HP:0200039)2.65090290
65IgG deficiency (HP:0004315)2.63819165
66Cutaneous melanoma (HP:0012056)2.60368633
67Small epiphyses (HP:0010585)2.59793880
68Optic neuritis (HP:0100653)2.52186860
69Retrobulbar optic neuritis (HP:0100654)2.52186860
70Myositis (HP:0100614)2.50498672
71Thrombocytosis (HP:0001894)2.49452153
72Aplastic anemia (HP:0001915)2.45899279
73Seborrheic dermatitis (HP:0001051)2.45016852
74Sepsis (HP:0100806)2.44554414
75Papilledema (HP:0001085)2.43368844
76Chest pain (HP:0100749)2.41536191
77Petechiae (HP:0000967)2.38017448
78Aplasia/Hypoplasia of the thymus (HP:0010515)2.36317612
79Arterial thrombosis (HP:0004420)2.29797756
80Arthralgia (HP:0002829)2.26709028
81Prolonged bleeding time (HP:0003010)2.25988617
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23597416
83Teleangiectasia of the skin (HP:0100585)2.22690507
84Abnormality of the nasal mucosa (HP:0000433)2.21730805
85Gingival bleeding (HP:0000225)2.19282108
86Spontaneous hematomas (HP:0007420)2.17516980
87Autoimmune thrombocytopenia (HP:0001973)2.17252519
88Myelodysplasia (HP:0002863)2.13010819
89Acute myeloid leukemia (HP:0004808)2.12141689
90Abnormality of macrophages (HP:0004311)2.10434765
91Hypergammaglobulinemia (HP:0010702)2.10233272
92Hypochromic anemia (HP:0001931)2.10228134
93Skin ulcer (HP:0200042)2.08328735
94Periodontitis (HP:0000704)2.06691431
95Mitral stenosis (HP:0001718)2.06439830
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04873217
97Neutropenia (HP:0001875)2.02768941
98Basal cell carcinoma (HP:0002671)2.01688743
99Abnormality of the heme biosynthetic pathway (HP:0010472)1.99982221
100Interstitial pulmonary disease (HP:0006530)1.97045063
101Vertebral arch anomaly (HP:0008438)1.95800264
102Abnormality of oral frenula (HP:0000190)1.95677902
103Orchitis (HP:0100796)1.95116445
104Xerostomia (HP:0000217)1.93808010
105Hypoplasia of the thymus (HP:0000778)1.93007720
106Epistaxis (HP:0000421)1.92339346
107Hepatitis (HP:0012115)1.91491656
108Abnormality of male internal genitalia (HP:0000022)1.91371275
109Combined immunodeficiency (HP:0005387)1.87703947
110Chromsome breakage (HP:0040012)1.87022595
111Acute hepatic failure (HP:0006554)1.86282364
112Abnormality of the prostate (HP:0008775)1.86209725
113Villous atrophy (HP:0011473)1.84734835
114Abnormality of small intestinal villus morphology (HP:0011472)1.84734835
115Polycythemia (HP:0001901)1.84604590
116Keratoconjunctivitis (HP:0001096)1.83969610
117Abnormality of the thymus (HP:0000777)1.83889418
118Cutis marmorata (HP:0000965)1.82861860
119Acrocyanosis (HP:0001063)1.81774707
120Abnormal platelet function (HP:0011869)1.81752179
121Impaired platelet aggregation (HP:0003540)1.81752179
122Myocardial infarction (HP:0001658)1.80983752
123Reticulocytosis (HP:0001923)1.80680743
124Urticaria (HP:0001025)1.80356393
125Annular pancreas (HP:0001734)1.78618184
126Severe combined immunodeficiency (HP:0004430)1.75157950
127Persistence of primary teeth (HP:0006335)1.74961030
128Lower limb asymmetry (HP:0100559)1.74733622
129Pulmonary fibrosis (HP:0002206)1.74497921
130Skin rash (HP:0000988)1.74307946
131Eosinophilia (HP:0001880)1.74215817
132Hemoptysis (HP:0002105)1.70038121
133Gastrointestinal infarctions (HP:0005244)1.69795506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.86897419
2MAP3K143.59162681
3PRPF4B3.45124543
4MAP3K133.07802515
5GRK62.90405570
6BLK2.71841120
7TYK22.62138387
8CSF1R2.60119432
9SYK2.38597783
10JAK32.30723207
11TXK2.25770443
12BTK2.20842647
13IRAK32.19820679
14IKBKB2.19512504
15STK102.16964023
16SIK22.15122840
17RIPK42.03299235
18LRRK21.94455721
19RPS6KB21.82623175
20CDC71.74405876
21CDK121.73033741
22SMG11.66851978
23* JAK11.60416760
24MAP3K101.59392929
25IRAK41.57286608
26ERN11.55564672
27CHUK1.54845260
28SIK31.53272421
29TBK11.46214396
30HCK1.45902109
31GRK11.43504196
32KIT1.41823520
33IKBKE1.40316090
34EEF2K1.40020020
35ZAP701.32135093
36PASK1.31773289
37CSK1.29424685
38LYN1.28412540
39FGFR31.27653174
40ITK1.26804653
41MST41.18066403
42LCK1.16516350
43TNK21.16271905
44MARK31.15417450
45PIM11.13621562
46TEC1.10042045
47PRKCQ1.08078280
48CLK11.06890393
49FGFR41.03800759
50MAP2K20.95978088
51BRD40.93531429
52ALK0.93083676
53KDR0.92818902
54TESK20.92443839
55EPHB10.88381170
56MAPK110.87838329
57HIPK20.85645144
58EIF2AK30.83640542
59CDC42BPA0.81528849
60TRPM70.80225681
61FES0.78601332
62JAK20.76713115
63PRKD20.72447454
64CDK90.72127448
65MAP3K70.71637855
66RPS6KA40.71348171
67FGR0.70913687
68SIK10.67688995
69STK40.65528352
70TGFBR20.65344409
71PRKCH0.64473040
72MAPKAPK30.64428143
73PDK10.63317919
74SGK30.61149964
75MAP3K80.60880689
76MAP3K10.59354206
77RET0.59108812
78PTK60.58237228
79CAMKK10.58091848
80ABL10.57150028
81MELK0.56418279
82MATK0.53709401
83NLK0.52242436
84EPHA30.52094685
85PLK40.50444192
86CDK40.49907361
87PRKAA20.49846152
88RPS6KC10.49492835
89RPS6KL10.49492835
90TAOK20.47390714
91MAP3K110.46321654
92PKN10.45204648
93NEK20.44307879
94MARK20.44122375
95CDK70.43957349
96INSR0.42465742
97IRAK10.42136359
98MAPK40.41974567
99WNK10.40032558
100CAMKK20.39626992
101MAPK70.39189163
102MAP2K30.39152222
103CHEK20.38319829
104CDK60.37718529
105RPS6KA60.37655695
106TAOK30.36940130
107YES10.36149782
108TLK10.35604458
109BMPR20.35369163
110FYN0.34849477
111STK240.33612214
112ICK0.32456974
113SGK20.32393612
114DAPK10.30476223
115MAP2K60.30429360
116MAPKAPK20.30114542
117EGFR0.29802821
118MAPK30.28156604
119MAPK120.27738739
120TRIB30.27443679
121CHEK10.27362334
122PRKCD0.26799167
123CAMK1G0.25122134
124PRKD10.23173678
125CSNK1A1L0.23076412
126SGK10.22278524
127STK110.22021149
128BMX0.20853108
129ATR0.20155454
130PKN20.20004646
131RPS6KA50.19816993

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.17344261
2B cell receptor signaling pathway_Homo sapiens_hsa046624.79174316
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.27328985
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.26223656
5* Hematopoietic cell lineage_Homo sapiens_hsa046403.00592832
6T cell receptor signaling pathway_Homo sapiens_hsa046602.46293171
7Asthma_Homo sapiens_hsa053102.24695635
8Leishmaniasis_Homo sapiens_hsa051402.21708549
9DNA replication_Homo sapiens_hsa030302.20528394
10Osteoclast differentiation_Homo sapiens_hsa043802.16639454
11Measles_Homo sapiens_hsa051622.10147498
12Allograft rejection_Homo sapiens_hsa053302.05352576
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02945772
14Antigen processing and presentation_Homo sapiens_hsa046122.01033918
15Autoimmune thyroid disease_Homo sapiens_hsa053201.94137347
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74172848
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73505830
18Chemokine signaling pathway_Homo sapiens_hsa040621.72121872
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68266029
20Herpes simplex infection_Homo sapiens_hsa051681.61846715
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58178666
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55262304
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47918235
24* Jak-STAT signaling pathway_Homo sapiens_hsa046301.46302783
25Toxoplasmosis_Homo sapiens_hsa051451.45923335
26Epstein-Barr virus infection_Homo sapiens_hsa051691.44069730
27Type I diabetes mellitus_Homo sapiens_hsa049401.35948783
28Tuberculosis_Homo sapiens_hsa051521.34044709
29Apoptosis_Homo sapiens_hsa042101.32019293
30TNF signaling pathway_Homo sapiens_hsa046681.15925345
31Influenza A_Homo sapiens_hsa051641.14864365
32Systemic lupus erythematosus_Homo sapiens_hsa053221.12452321
33Chronic myeloid leukemia_Homo sapiens_hsa052201.11330642
34Hepatitis B_Homo sapiens_hsa051611.11215523
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10560676
36Acute myeloid leukemia_Homo sapiens_hsa052211.08728941
37Malaria_Homo sapiens_hsa051441.01356966
38African trypanosomiasis_Homo sapiens_hsa051431.01128829
39Leukocyte transendothelial migration_Homo sapiens_hsa046700.99175247
40Other glycan degradation_Homo sapiens_hsa005110.96740946
41Non-small cell lung cancer_Homo sapiens_hsa052230.96509943
42Cell cycle_Homo sapiens_hsa041100.95412252
43Neurotrophin signaling pathway_Homo sapiens_hsa047220.94737988
44* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94696137
45Platelet activation_Homo sapiens_hsa046110.94538215
46Non-homologous end-joining_Homo sapiens_hsa034500.94266583
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93637702
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90171326
49Shigellosis_Homo sapiens_hsa051310.88635957
50Pancreatic cancer_Homo sapiens_hsa052120.88539197
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87673630
52Viral carcinogenesis_Homo sapiens_hsa052030.86494944
53Small cell lung cancer_Homo sapiens_hsa052220.86476319
54Viral myocarditis_Homo sapiens_hsa054160.85638454
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84896009
56HTLV-I infection_Homo sapiens_hsa051660.84040354
57Mismatch repair_Homo sapiens_hsa034300.83167430
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81428618
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79803920
60Hepatitis C_Homo sapiens_hsa051600.79356412
61Thyroid cancer_Homo sapiens_hsa052160.77916334
62MAPK signaling pathway_Homo sapiens_hsa040100.77875006
63Homologous recombination_Homo sapiens_hsa034400.72990085
64Notch signaling pathway_Homo sapiens_hsa043300.68225539
65p53 signaling pathway_Homo sapiens_hsa041150.67568872
66Base excision repair_Homo sapiens_hsa034100.66505065
67Prolactin signaling pathway_Homo sapiens_hsa049170.66427934
68Alcoholism_Homo sapiens_hsa050340.65662690
69Legionellosis_Homo sapiens_hsa051340.64132140
70FoxO signaling pathway_Homo sapiens_hsa040680.63658489
71Ribosome_Homo sapiens_hsa030100.62327439
72Nucleotide excision repair_Homo sapiens_hsa034200.60395298
73Inositol phosphate metabolism_Homo sapiens_hsa005620.58983436
74Graft-versus-host disease_Homo sapiens_hsa053320.58272650
75Pertussis_Homo sapiens_hsa051330.56341165
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55480881
77MicroRNAs in cancer_Homo sapiens_hsa052060.55439822
78Lysine degradation_Homo sapiens_hsa003100.55408350
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53199669
80RNA transport_Homo sapiens_hsa030130.50965986
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49011886
82VEGF signaling pathway_Homo sapiens_hsa043700.48708176
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47176859
84Dorso-ventral axis formation_Homo sapiens_hsa043200.46882625
85ErbB signaling pathway_Homo sapiens_hsa040120.46724921
86Salmonella infection_Homo sapiens_hsa051320.46619321
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45548843
88Type II diabetes mellitus_Homo sapiens_hsa049300.43391920
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42888817
90Pentose phosphate pathway_Homo sapiens_hsa000300.41754433
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41030313
92Insulin resistance_Homo sapiens_hsa049310.39992163
93Prostate cancer_Homo sapiens_hsa052150.39040611
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37870514
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37451764
96Colorectal cancer_Homo sapiens_hsa052100.37451302
97One carbon pool by folate_Homo sapiens_hsa006700.35654585
98Renal cell carcinoma_Homo sapiens_hsa052110.35211070
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.34939098
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.34709428
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34560491
102Endocytosis_Homo sapiens_hsa041440.33267977
103Choline metabolism in cancer_Homo sapiens_hsa052310.32661025
104HIF-1 signaling pathway_Homo sapiens_hsa040660.32102851
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.31885472
106ABC transporters_Homo sapiens_hsa020100.30972529
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30391730
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.30013929
109Pathways in cancer_Homo sapiens_hsa052000.29683423
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29640644
111Spliceosome_Homo sapiens_hsa030400.29496545
112Proteoglycans in cancer_Homo sapiens_hsa052050.28890000
113Fanconi anemia pathway_Homo sapiens_hsa034600.28654456
114mTOR signaling pathway_Homo sapiens_hsa041500.27431919
115mRNA surveillance pathway_Homo sapiens_hsa030150.25552688
116Staphylococcus aureus infection_Homo sapiens_hsa051500.25523629
117Rheumatoid arthritis_Homo sapiens_hsa053230.24206136
118Glioma_Homo sapiens_hsa052140.22972787
119Endometrial cancer_Homo sapiens_hsa052130.21968333

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