IL9RP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)5.70244849
2positive regulation of gamma-delta T cell activation (GO:0046645)5.63699628
3negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.52808335
4positive regulation of B cell differentiation (GO:0045579)5.47320788
5response to interleukin-15 (GO:0070672)5.35330509
6B cell receptor signaling pathway (GO:0050853)4.66075874
7regulation of B cell differentiation (GO:0045577)4.50472781
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.48290871
9regulation of B cell receptor signaling pathway (GO:0050855)4.36736241
10regulation of gamma-delta T cell activation (GO:0046643)4.31554873
11regulation of gamma-delta T cell differentiation (GO:0045586)4.20725175
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.16394340
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98326966
14antigen processing and presentation of endogenous antigen (GO:0019883)3.96073723
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94403514
16negative regulation of cell killing (GO:0031342)3.94403514
17positive thymic T cell selection (GO:0045059)3.88240539
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76568903
19purinergic nucleotide receptor signaling pathway (GO:0035590)3.68408986
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68377958
21response to peptidoglycan (GO:0032494)3.63769953
22response to muramyl dipeptide (GO:0032495)3.60769406
23positive regulation of granulocyte differentiation (GO:0030854)3.57032153
24thymic T cell selection (GO:0045061)3.53860445
25negative thymic T cell selection (GO:0045060)3.47697462
26regulation of interferon-beta biosynthetic process (GO:0045357)3.47224059
27tolerance induction (GO:0002507)3.34762166
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33947051
29B cell homeostasis (GO:0001782)3.30110600
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.28029020
31modulation by symbiont of host immune response (GO:0052553)3.28029020
32positive regulation by symbiont of host defense response (GO:0052509)3.28029020
33modulation by symbiont of host defense response (GO:0052031)3.28029020
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28029020
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28029020
36regulation of histone H3-K27 methylation (GO:0061085)3.25996750
37negative T cell selection (GO:0043383)3.23563229
38immunoglobulin mediated immune response (GO:0016064)3.22378871
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21937236
40GDP-mannose metabolic process (GO:0019673)3.15956980
41T cell selection (GO:0045058)3.15622747
42positive regulation of protein homooligomerization (GO:0032464)3.14941037
43macrophage activation involved in immune response (GO:0002281)3.13735906
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09481901
45leukocyte aggregation (GO:0070486)3.05563942
46regulation of granulocyte differentiation (GO:0030852)3.05329077
47positive regulation of interferon-alpha production (GO:0032727)3.02160522
48positive T cell selection (GO:0043368)3.00164912
49negative regulation of erythrocyte differentiation (GO:0045647)2.95934629
503-UTR-mediated mRNA stabilization (GO:0070935)2.95051646
51mannose metabolic process (GO:0006013)2.92954854
52G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.92784167
53positive regulation of B cell activation (GO:0050871)2.91110867
54histone H3-K36 demethylation (GO:0070544)2.86411227
55regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85892816
56purinergic receptor signaling pathway (GO:0035587)2.84708321
57detection of bacterium (GO:0016045)2.84189463
58neutrophil activation involved in immune response (GO:0002283)2.83982869
59detection of other organism (GO:0098543)2.82370190
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81490313
61germinal center formation (GO:0002467)2.81470382
62CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79140901
63negative regulation of innate immune response (GO:0045824)2.77262682
64NIK/NF-kappaB signaling (GO:0038061)2.77168683
65respiratory burst (GO:0045730)2.75313850
66regulation of interferon-alpha production (GO:0032647)2.73780942
67negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73614048
68lymphocyte homeostasis (GO:0002260)2.73319091
69negative regulation of interleukin-6 production (GO:0032715)2.72895502
70myeloid cell activation involved in immune response (GO:0002275)2.71607005
71antigen receptor-mediated signaling pathway (GO:0050851)2.71468883
72negative regulation of histone methylation (GO:0031061)2.71089858
73negative regulation of T cell mediated immunity (GO:0002710)2.69357087
74cellular extravasation (GO:0045123)2.68474288
75negative regulation of type I interferon production (GO:0032480)2.68224767
76defense response to protozoan (GO:0042832)2.67088274
77mature B cell differentiation involved in immune response (GO:0002313)2.66457294
78T cell homeostasis (GO:0043029)2.65153482
79regulation of B cell proliferation (GO:0030888)2.65077734
80negative regulation of interleukin-12 production (GO:0032695)2.64967975
81B cell mediated immunity (GO:0019724)2.64284138
82negative regulation of lymphocyte mediated immunity (GO:0002707)2.62724706
83regulation of mast cell degranulation (GO:0043304)2.61468247
84positive regulation of B cell proliferation (GO:0030890)2.60711250
85mature B cell differentiation (GO:0002335)2.60002294
86chaperone mediated protein folding requiring cofactor (GO:0051085)2.59582267
87T cell migration (GO:0072678)2.59402327
88negative regulation of response to biotic stimulus (GO:0002832)2.58579445
89histone H3-K4 trimethylation (GO:0080182)2.55146563
90negative regulation of phagocytosis (GO:0050765)2.54687407
91response to protozoan (GO:0001562)2.54479761
92programmed necrotic cell death (GO:0097300)2.53912107
93detection of external biotic stimulus (GO:0098581)2.51734794
94mucosal-associated lymphoid tissue development (GO:0048537)2.50880150
95Peyers patch development (GO:0048541)2.50880150
96cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.50705156
97regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49080896
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48420346
99negative regulation of B cell proliferation (GO:0030889)2.47304335
100regulation of interferon-beta production (GO:0032648)2.44437802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.08187490
2VDR_21846776_ChIP-Seq_THP-1_Human3.98012385
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.77078907
4E2F7_22180533_ChIP-Seq_HELA_Human3.35266695
5MAF_26560356_Chip-Seq_TH1_Human2.65171765
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57708059
7VDR_24763502_ChIP-Seq_THP-1_Human2.54161453
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49836920
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42081495
10MAF_26560356_Chip-Seq_TH2_Human2.35026596
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32065748
12UTX_26944678_Chip-Seq_JUKART_Human2.20730020
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19874139
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.16441454
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14294304
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11097255
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09220015
18TCF7_22412390_ChIP-Seq_EML_Mouse2.08159066
19SCL_19346495_ChIP-Seq_HPC-7_Human2.05632192
20LXR_22292898_ChIP-Seq_THP-1_Human2.00544746
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.98357911
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96299447
23KDM2B_26808549_Chip-Seq_DND41_Human1.90967117
24CIITA_25753668_ChIP-Seq_RAJI_Human1.89869063
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81196142
26MYB_26560356_Chip-Seq_TH1_Human1.80215323
27SPI1_23547873_ChIP-Seq_NB4_Human1.80092665
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.77785034
29MYB_26560356_Chip-Seq_TH2_Human1.75412917
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.74764415
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73091137
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68302784
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67837539
34P68_20966046_ChIP-Seq_HELA_Human1.63876792
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61928886
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.60611410
37BCOR_27268052_Chip-Seq_Bcells_Human1.58159315
38BCL6_27268052_Chip-Seq_Bcells_Human1.55984158
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.53958846
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52733222
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51277154
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50547529
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49403940
44RACK7_27058665_Chip-Seq_MCF-7_Human1.47364767
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47007017
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44767249
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40831075
48NCOR1_26117541_ChIP-Seq_K562_Human1.39335984
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39057156
50SPI1_23127762_ChIP-Seq_K562_Human1.37705518
51RUNX_20019798_ChIP-Seq_JUKART_Human1.37551784
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35619272
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.35155939
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34268772
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34231346
56GATA1_22025678_ChIP-Seq_K562_Human1.33423847
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31831163
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31091664
59XRN2_22483619_ChIP-Seq_HELA_Human1.30451705
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.27885167
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26143949
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24956620
63SMC4_20622854_ChIP-Seq_HELA_Human1.24227589
64KDM5A_27292631_Chip-Seq_BREAST_Human1.22379992
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22123469
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21992418
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.20744629
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.20073711
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17999250
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17802185
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17501282
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16258087
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.15818733
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15720276
75E2F1_20622854_ChIP-Seq_HELA_Human1.14527018
76ETS1_21867929_ChIP-Seq_TH2_Mouse1.14396422
77GATA3_27048872_Chip-Seq_THYMUS_Human1.11472223
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11369099
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.10969665
80PHF8_20622854_ChIP-Seq_HELA_Human1.09606045
81CTCF_21964334_Chip-Seq_Bcells_Human1.09557006
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09423514
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08068503
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07996961
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06591134
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05538942
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04643972
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03347333
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02454647
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02299869
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01789867
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00972501
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00843177
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98775462
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98664037
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98634325
97RARB_24833708_ChIP-Seq_LIVER_Mouse0.97890208
98DCP1A_22483619_ChIP-Seq_HELA_Human0.97538114
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97380630
100CREB1_26743006_Chip-Seq_LNCaP_Human0.97115483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.49955014
2MP0003763_abnormal_thymus_physiology3.25479459
3MP0001800_abnormal_humoral_immune3.12753567
4MP0000685_abnormal_immune_system3.12173852
5MP0003436_decreased_susceptibility_to3.10944301
6MP0003303_peritoneal_inflammation2.81343780
7MP0002396_abnormal_hematopoietic_system2.81294004
8MP0005671_abnormal_response_to2.78119704
9MP0001986_abnormal_taste_sensitivity2.77557599
10MP0008057_abnormal_DNA_replication2.58666854
11MP0004381_abnormal_hair_follicle2.58610612
12MP0001790_abnormal_immune_system2.56250413
13MP0005387_immune_system_phenotype2.56250413
14MP0005000_abnormal_immune_tolerance2.50799764
15MP0005174_abnormal_tail_pigmentation2.44396315
16MP0009278_abnormal_bone_marrow2.42175781
17MP0002723_abnormal_immune_serum2.40049923
18MP0002452_abnormal_antigen_presenting2.39736603
19MP0002420_abnormal_adaptive_immunity2.36744738
20MP0001819_abnormal_immune_cell2.35024965
21MP0002398_abnormal_bone_marrow2.34724542
22MP0010094_abnormal_chromosome_stability2.17945140
23MP0005025_abnormal_response_to2.17873379
24MP0005451_abnormal_body_composition2.10987088
25MP0000015_abnormal_ear_pigmentation2.09280303
26MP0009333_abnormal_splenocyte_physiolog2.06776590
27MP0000716_abnormal_immune_system2.04948050
28MP0002419_abnormal_innate_immunity2.00496122
29MP0003111_abnormal_nucleus_morphology1.92589636
30MP0000689_abnormal_spleen_morphology1.91702555
31MP0005409_darkened_coat_color1.89626178
32MP0002722_abnormal_immune_system1.85295575
33MP0002429_abnormal_blood_cell1.84392134
34MP0000703_abnormal_thymus_morphology1.80030874
35MP0003172_abnormal_lysosome_physiology1.73468927
36MP0004947_skin_inflammation1.70270786
37MP0002405_respiratory_system_inflammati1.62374165
38MP0005076_abnormal_cell_differentiation1.62090885
39MP0004808_abnormal_hematopoietic_stem1.56686424
40MP0002148_abnormal_hypersensitivity_rea1.55992747
41MP0002009_preneoplasia1.53427719
42MP0010155_abnormal_intestine_physiology1.51396658
43MP0008260_abnormal_autophagy1.50246328
44MP0009785_altered_susceptibility_to1.49653324
45MP0001873_stomach_inflammation1.46079783
46MP0002019_abnormal_tumor_incidence1.45913847
47MP0008007_abnormal_cellular_replicative1.45332493
48MP0005171_absent_coat_pigmentation1.42116107
49MP0002166_altered_tumor_susceptibility1.42020755
50MP0003077_abnormal_cell_cycle1.40884296
51MP0003724_increased_susceptibility_to1.34168311
52MP0001845_abnormal_inflammatory_respons1.31995373
53MP0005464_abnormal_platelet_physiology1.31558910
54MP0005083_abnormal_biliary_tract1.30387336
55MP0003693_abnormal_embryo_hatching1.25656075
56MP0003136_yellow_coat_color1.24951562
57MP0005310_abnormal_salivary_gland1.19381703
58MP0001545_abnormal_hematopoietic_system1.16890979
59MP0005397_hematopoietic_system_phenotyp1.16890979
60MP0005075_abnormal_melanosome_morpholog1.09975727
61MP0001853_heart_inflammation1.05063371
62MP0003300_gastrointestinal_ulcer1.03001183
63MP0003866_abnormal_defecation1.02772512
64MP0005423_abnormal_somatic_nervous0.99793714
65MP0004264_abnormal_extraembryonic_tissu0.98476746
66MP0003453_abnormal_keratinocyte_physiol0.97240974
67MP0004957_abnormal_blastocyst_morpholog0.96478352
68MP0002653_abnormal_ependyma_morphology0.91057079
69MP0000350_abnormal_cell_proliferation0.88922053
70MP0009840_abnormal_foam_cell0.86301888
71MP0000371_diluted_coat_color0.86213253
72MP0008469_abnormal_protein_level0.86192456
73MP0000313_abnormal_cell_death0.86004247
74MP0002006_tumorigenesis0.84938550
75MP0000490_abnormal_crypts_of0.84365151
76MP0000858_altered_metastatic_potential0.82896100
77MP0001533_abnormal_skeleton_physiology0.82555785
78MP0002132_abnormal_respiratory_system0.81901390
79MP0003828_pulmonary_edema0.81854208
80MP0003943_abnormal_hepatobiliary_system0.81589492
81MP0003191_abnormal_cellular_cholesterol0.78071730
82MP0005621_abnormal_cell_physiology0.77719035
83MP0005058_abnormal_lysosome_morphology0.77416869
84MP0008961_abnormal_basal_metabolism0.74939073
85MP0003705_abnormal_hypodermis_morpholog0.69514888
86MP0009764_decreased_sensitivity_to0.68411931
87MP0000465_gastrointestinal_hemorrhage0.66514115
88MP0006082_CNS_inflammation0.64873971
89MP0002933_joint_inflammation0.62889386
90MP0003656_abnormal_erythrocyte_physiolo0.61999964
91MP0001851_eye_inflammation0.61108053
92MP0009931_abnormal_skin_appearance0.60526054
93MP0008058_abnormal_DNA_repair0.59797994
94MP0006036_abnormal_mitochondrial_physio0.59306421
95MP0006035_abnormal_mitochondrial_morpho0.59120536
96MP0010307_abnormal_tumor_latency0.58760229
97MP0001663_abnormal_digestive_system0.58601525
98MP0002075_abnormal_coat/hair_pigmentati0.57902613
99MP0005384_cellular_phenotype0.57254299
100MP0000367_abnormal_coat/_hair0.55298930

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.55045906
2Colitis (HP:0002583)4.19111886
3Cellulitis (HP:0100658)4.06430532
4Eczematoid dermatitis (HP:0000976)3.98670667
5Meningitis (HP:0001287)3.80752098
6Panhypogammaglobulinemia (HP:0003139)3.80523096
7Recurrent abscess formation (HP:0002722)3.69971345
8Recurrent cutaneous fungal infections (HP:0011370)3.66770070
9Chronic mucocutaneous candidiasis (HP:0002728)3.66770070
10Recurrent fungal infections (HP:0002841)3.65807441
11Recurrent bacterial skin infections (HP:0005406)3.60289200
12Recurrent sinusitis (HP:0011108)3.53435718
13Recurrent viral infections (HP:0004429)3.53260854
14Pustule (HP:0200039)3.34246778
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.31929212
16Gastrointestinal inflammation (HP:0004386)3.28200911
17Chronic obstructive pulmonary disease (HP:0006510)3.21024190
18Obstructive lung disease (HP:0006536)3.21024190
19Verrucae (HP:0200043)3.20449144
20Papilloma (HP:0012740)3.20449144
21Inflammation of the large intestine (HP:0002037)3.19022187
22Gastrointestinal stroma tumor (HP:0100723)3.13023455
23Abnormality of the fingertips (HP:0001211)3.03988288
24Annular pancreas (HP:0001734)2.98446278
25Poikiloderma (HP:0001029)2.96950078
26Abnormality of macrophages (HP:0004311)2.93279530
27Mediastinal lymphadenopathy (HP:0100721)2.90725294
28Lymphopenia (HP:0001888)2.86283930
29Recurrent skin infections (HP:0001581)2.86152397
30Severe combined immunodeficiency (HP:0004430)2.79445911
31Elevated erythrocyte sedimentation rate (HP:0003565)2.76742861
32Viral hepatitis (HP:0006562)2.75211716
33Osteomyelitis (HP:0002754)2.73198444
34Intestinal fistula (HP:0100819)2.72036499
35Chronic diarrhea (HP:0002028)2.71586601
36Hemorrhage of the eye (HP:0011885)2.66144128
37Abnormality of cells of the lymphoid lineage (HP:0012140)2.61078659
38Squamous cell carcinoma (HP:0002860)2.59533735
39Emphysema (HP:0002097)2.58010725
40Vasculitis (HP:0002633)2.54723896
41Sepsis (HP:0100806)2.54486661
42Birth length less than 3rd percentile (HP:0003561)2.52507436
43Rib fusion (HP:0000902)2.51748988
44Myositis (HP:0100614)2.49926427
45Gastrointestinal infarctions (HP:0005244)2.49814040
46Progressive external ophthalmoplegia (HP:0000590)2.49530477
47Recurrent pneumonia (HP:0006532)2.46744460
48Basal cell carcinoma (HP:0002671)2.46113169
49Encephalitis (HP:0002383)2.46014951
50Abnormality of T cell physiology (HP:0011840)2.42580252
51Granulocytopenia (HP:0001913)2.42450132
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38828571
53Hypochromic anemia (HP:0001931)2.36175621
54Recurrent bronchitis (HP:0002837)2.35952178
55Lymphoma (HP:0002665)2.31369017
56Combined immunodeficiency (HP:0005387)2.30465471
57Recurrent lower respiratory tract infections (HP:0002783)2.30146580
58Chronic sinusitis (HP:0011109)2.29715592
59Abnormality of T cells (HP:0002843)2.29602161
60Increased IgE level (HP:0003212)2.28256845
61Rectal fistula (HP:0100590)2.27049789
62Rectovaginal fistula (HP:0000143)2.27049789
63Recurrent gram-negative bacterial infections (HP:0005420)2.25911115
64Thin bony cortex (HP:0002753)2.20633263
65Chromsome breakage (HP:0040012)2.19991852
66Hypoplasia of the thymus (HP:0000778)2.18127073
67B lymphocytopenia (HP:0010976)2.17728963
68Prominent nose (HP:0000448)2.16857795
69Aplasia/Hypoplasia of the thymus (HP:0010515)2.13336730
70Leukopenia (HP:0001882)2.12229460
71Stomatitis (HP:0010280)2.11955208
72Abnormality of B cell number (HP:0010975)2.11496780
73Testicular atrophy (HP:0000029)2.11352741
74Vaginal fistula (HP:0004320)2.11008443
75Breast hypoplasia (HP:0003187)2.10628636
76Facial hemangioma (HP:0000329)2.10342779
77Skin rash (HP:0000988)2.06767165
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05019081
79Progressive muscle weakness (HP:0003323)2.03032244
80Sparse lateral eyebrow (HP:0005338)1.99774814
81IgM deficiency (HP:0002850)1.99350679
82Short chin (HP:0000331)1.99113894
83Prolonged bleeding time (HP:0003010)1.98169837
84Abnormality of the columella (HP:0009929)1.96746629
85Ulnar bowing (HP:0003031)1.96395630
86T lymphocytopenia (HP:0005403)1.96237588
87Easy fatigability (HP:0003388)1.95944706
88Hepatitis (HP:0012115)1.94724878
89Chest pain (HP:0100749)1.94564717
90Restrictive lung disease (HP:0002091)1.93107078
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.92539127
92Petechiae (HP:0000967)1.91376112
93Flat occiput (HP:0005469)1.90892914
94Abnormality of pyrimidine metabolism (HP:0004353)1.90288160
95Recurrent otitis media (HP:0000403)1.89144774
96Absent thumb (HP:0009777)1.88430198
97Chronic otitis media (HP:0000389)1.87484304
98Epistaxis (HP:0000421)1.85694532
99Anorexia (HP:0002039)1.85321581
100Gingivitis (HP:0000230)1.84246116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.26070863
2MAP4K14.20180564
3BLK3.55278195
4RIPK43.02228710
5TRIB32.68847105
6ERN12.66726164
7IRAK42.46976431
8SMG12.25762760
9CDK122.16026303
10GRK62.13600408
11MAP2K32.13368536
12PRPF4B2.01202232
13BTK1.89455020
14MAP3K101.83062893
15EEF2K1.78470929
16MAP3K131.77296589
17TESK21.74680840
18MAP3K141.72509715
19TYK21.68936923
20SYK1.66953871
21ZAP701.63605465
22CSF1R1.61352782
23TNK21.56287515
24SIK11.55328799
25SIK21.47450703
26CDK41.46781587
27TBK11.44882585
28JAK11.37841418
29TLK11.37752638
30MAPK121.35971738
31MAPK151.33174684
32MAP2K21.32135031
33HCK1.31411120
34ICK1.29886359
35NEK61.29137312
36JAK31.28767208
37IKBKE1.24777714
38MAPK111.21352717
39FES1.21091641
40MAPKAPK31.18972507
41IRAK21.18694298
42PDPK11.11685896
43CSK1.11088089
44IKBKB0.99026995
45MAPK70.97581964
46LYN0.96709468
47PDK10.93404998
48SIK30.86972441
49ITK0.85751402
50CDK60.85651852
51HIPK20.81628516
52MAP3K70.79989081
53MARK20.79279339
54TRIM280.77922010
55KIT0.77148940
56IRAK10.70928745
57LCK0.70852241
58PRKD20.69872441
59MAP3K110.69419768
60MELK0.68085153
61MARK30.65201010
62IRAK30.64525392
63MTOR0.61246590
64KSR20.57397888
65BMPR20.56441037
66MAP3K30.55870782
67PIM10.54723834
68MAP3K10.53699286
69RPS6KB20.53494728
70RPS6KC10.52937917
71RPS6KL10.52937917
72ATR0.52903494
73MUSK0.52050442
74CAMK1D0.51596024
75STK100.49836190
76TEC0.48858055
77FGFR40.48058968
78PRKCQ0.47464524
79PKN20.47236736
80EPHB10.45628597
81RPS6KA60.45508796
82TXK0.44898682
83CDC42BPA0.44781812
84RAF10.43012035
85PASK0.42977646
86CHUK0.42440479
87LRRK20.42359435
88PIK3CG0.42338968
89KDR0.40558669
90MAP3K80.39908043
91ZAK0.39778429
92JAK20.39725487
93NEK20.37406670
94PIM20.36908348
95CAMKK10.36364789
96NME20.35000644
97MAP2K60.32616255
98MAPKAPK20.32511818
99DAPK10.29405999
100CDC70.29167599

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.71864386
2B cell receptor signaling pathway_Homo sapiens_hsa046623.22296945
3Leishmaniasis_Homo sapiens_hsa051402.15297562
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.10714409
5Osteoclast differentiation_Homo sapiens_hsa043802.01722727
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.01454627
7Acute myeloid leukemia_Homo sapiens_hsa052212.00195756
8Allograft rejection_Homo sapiens_hsa053301.93789171
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.84020909
10Graft-versus-host disease_Homo sapiens_hsa053321.80396046
11Non-small cell lung cancer_Homo sapiens_hsa052231.73500131
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72538452
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69714093
14DNA replication_Homo sapiens_hsa030301.69573094
15Other glycan degradation_Homo sapiens_hsa005111.64998526
16T cell receptor signaling pathway_Homo sapiens_hsa046601.64297351
17Autoimmune thyroid disease_Homo sapiens_hsa053201.63579634
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59945710
19Sulfur relay system_Homo sapiens_hsa041221.55629500
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52538125
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50027455
22Asthma_Homo sapiens_hsa053101.49876813
23Tuberculosis_Homo sapiens_hsa051521.48795129
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48731742
25Herpes simplex infection_Homo sapiens_hsa051681.44443654
26Toxoplasmosis_Homo sapiens_hsa051451.43912528
27Influenza A_Homo sapiens_hsa051641.43894532
28Pancreatic cancer_Homo sapiens_hsa052121.43122812
29Hematopoietic cell lineage_Homo sapiens_hsa046401.40906155
30Non-homologous end-joining_Homo sapiens_hsa034501.38936909
31Staphylococcus aureus infection_Homo sapiens_hsa051501.35854865
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35316090
33Chronic myeloid leukemia_Homo sapiens_hsa052201.35061961
34Fructose and mannose metabolism_Homo sapiens_hsa000511.34447618
35Measles_Homo sapiens_hsa051621.33557927
36Antigen processing and presentation_Homo sapiens_hsa046121.31941073
37Hepatitis B_Homo sapiens_hsa051611.28938222
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27080303
39Viral carcinogenesis_Homo sapiens_hsa052031.26755553
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.23381394
41Type I diabetes mellitus_Homo sapiens_hsa049401.22472513
42Homologous recombination_Homo sapiens_hsa034401.21321696
43Viral myocarditis_Homo sapiens_hsa054161.18813605
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18208818
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15721357
46Base excision repair_Homo sapiens_hsa034101.13337208
47Fanconi anemia pathway_Homo sapiens_hsa034601.11889141
48Epstein-Barr virus infection_Homo sapiens_hsa051691.10800312
49Systemic lupus erythematosus_Homo sapiens_hsa053221.09956361
50VEGF signaling pathway_Homo sapiens_hsa043701.04822893
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02630791
52Hepatitis C_Homo sapiens_hsa051601.01670879
53Apoptosis_Homo sapiens_hsa042101.00880491
54mTOR signaling pathway_Homo sapiens_hsa041500.99860123
55TNF signaling pathway_Homo sapiens_hsa046680.98950953
56HTLV-I infection_Homo sapiens_hsa051660.97877917
57Endometrial cancer_Homo sapiens_hsa052130.93614864
58Chemokine signaling pathway_Homo sapiens_hsa040620.92938979
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91686047
60Inositol phosphate metabolism_Homo sapiens_hsa005620.89062746
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83461177
62Colorectal cancer_Homo sapiens_hsa052100.82937641
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79650526
64Insulin resistance_Homo sapiens_hsa049310.75798400
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.73936658
66Legionellosis_Homo sapiens_hsa051340.72997519
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.70809359
68FoxO signaling pathway_Homo sapiens_hsa040680.68145031
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67358121
70Platelet activation_Homo sapiens_hsa046110.67090514
71Prostate cancer_Homo sapiens_hsa052150.64525436
72Notch signaling pathway_Homo sapiens_hsa043300.64395128
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64386411
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61172372
75Lysine degradation_Homo sapiens_hsa003100.60319065
76Cell cycle_Homo sapiens_hsa041100.59033743
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59010572
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.58663869
79Bladder cancer_Homo sapiens_hsa052190.57004541
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.56230117
81Galactose metabolism_Homo sapiens_hsa000520.56100589
82Sphingolipid metabolism_Homo sapiens_hsa006000.55780281
83Choline metabolism in cancer_Homo sapiens_hsa052310.55560353
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.54783614
85Small cell lung cancer_Homo sapiens_hsa052220.54668496
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.54170447
87Shigellosis_Homo sapiens_hsa051310.53214274
88Prolactin signaling pathway_Homo sapiens_hsa049170.51331918
89Renal cell carcinoma_Homo sapiens_hsa052110.49902074
90Pentose phosphate pathway_Homo sapiens_hsa000300.48550911
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47930662
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46978239
93Alcoholism_Homo sapiens_hsa050340.45921307
94Malaria_Homo sapiens_hsa051440.44256067
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43622233
96Pyrimidine metabolism_Homo sapiens_hsa002400.41108440
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41006995
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40846791
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40210534
100Mismatch repair_Homo sapiens_hsa034300.40058277

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