Rank | Gene Set | Z-score |
---|---|---|
1 | cellular response to interleukin-15 (GO:0071350) | 5.70244849 |
2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.63699628 |
3 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 5.52808335 |
4 | positive regulation of B cell differentiation (GO:0045579) | 5.47320788 |
5 | response to interleukin-15 (GO:0070672) | 5.35330509 |
6 | B cell receptor signaling pathway (GO:0050853) | 4.66075874 |
7 | regulation of B cell differentiation (GO:0045577) | 4.50472781 |
8 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 4.48290871 |
9 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.36736241 |
10 | regulation of gamma-delta T cell activation (GO:0046643) | 4.31554873 |
11 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.20725175 |
12 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 4.16394340 |
13 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.98326966 |
14 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.96073723 |
15 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.94403514 |
16 | negative regulation of cell killing (GO:0031342) | 3.94403514 |
17 | positive thymic T cell selection (GO:0045059) | 3.88240539 |
18 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.76568903 |
19 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 3.68408986 |
20 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.68377958 |
21 | response to peptidoglycan (GO:0032494) | 3.63769953 |
22 | response to muramyl dipeptide (GO:0032495) | 3.60769406 |
23 | positive regulation of granulocyte differentiation (GO:0030854) | 3.57032153 |
24 | thymic T cell selection (GO:0045061) | 3.53860445 |
25 | negative thymic T cell selection (GO:0045060) | 3.47697462 |
26 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.47224059 |
27 | tolerance induction (GO:0002507) | 3.34762166 |
28 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.33947051 |
29 | B cell homeostasis (GO:0001782) | 3.30110600 |
30 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.28029020 |
31 | modulation by symbiont of host immune response (GO:0052553) | 3.28029020 |
32 | positive regulation by symbiont of host defense response (GO:0052509) | 3.28029020 |
33 | modulation by symbiont of host defense response (GO:0052031) | 3.28029020 |
34 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.28029020 |
35 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.28029020 |
36 | regulation of histone H3-K27 methylation (GO:0061085) | 3.25996750 |
37 | negative T cell selection (GO:0043383) | 3.23563229 |
38 | immunoglobulin mediated immune response (GO:0016064) | 3.22378871 |
39 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.21937236 |
40 | GDP-mannose metabolic process (GO:0019673) | 3.15956980 |
41 | T cell selection (GO:0045058) | 3.15622747 |
42 | positive regulation of protein homooligomerization (GO:0032464) | 3.14941037 |
43 | macrophage activation involved in immune response (GO:0002281) | 3.13735906 |
44 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.09481901 |
45 | leukocyte aggregation (GO:0070486) | 3.05563942 |
46 | regulation of granulocyte differentiation (GO:0030852) | 3.05329077 |
47 | positive regulation of interferon-alpha production (GO:0032727) | 3.02160522 |
48 | positive T cell selection (GO:0043368) | 3.00164912 |
49 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.95934629 |
50 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.95051646 |
51 | mannose metabolic process (GO:0006013) | 2.92954854 |
52 | G-protein coupled purinergic receptor signaling pathway (GO:0035588) | 2.92784167 |
53 | positive regulation of B cell activation (GO:0050871) | 2.91110867 |
54 | histone H3-K36 demethylation (GO:0070544) | 2.86411227 |
55 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.85892816 |
56 | purinergic receptor signaling pathway (GO:0035587) | 2.84708321 |
57 | detection of bacterium (GO:0016045) | 2.84189463 |
58 | neutrophil activation involved in immune response (GO:0002283) | 2.83982869 |
59 | detection of other organism (GO:0098543) | 2.82370190 |
60 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.81490313 |
61 | germinal center formation (GO:0002467) | 2.81470382 |
62 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.79140901 |
63 | negative regulation of innate immune response (GO:0045824) | 2.77262682 |
64 | NIK/NF-kappaB signaling (GO:0038061) | 2.77168683 |
65 | respiratory burst (GO:0045730) | 2.75313850 |
66 | regulation of interferon-alpha production (GO:0032647) | 2.73780942 |
67 | negative regulation of toll-like receptor signaling pathway (GO:0034122) | 2.73614048 |
68 | lymphocyte homeostasis (GO:0002260) | 2.73319091 |
69 | negative regulation of interleukin-6 production (GO:0032715) | 2.72895502 |
70 | myeloid cell activation involved in immune response (GO:0002275) | 2.71607005 |
71 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.71468883 |
72 | negative regulation of histone methylation (GO:0031061) | 2.71089858 |
73 | negative regulation of T cell mediated immunity (GO:0002710) | 2.69357087 |
74 | cellular extravasation (GO:0045123) | 2.68474288 |
75 | negative regulation of type I interferon production (GO:0032480) | 2.68224767 |
76 | defense response to protozoan (GO:0042832) | 2.67088274 |
77 | mature B cell differentiation involved in immune response (GO:0002313) | 2.66457294 |
78 | T cell homeostasis (GO:0043029) | 2.65153482 |
79 | regulation of B cell proliferation (GO:0030888) | 2.65077734 |
80 | negative regulation of interleukin-12 production (GO:0032695) | 2.64967975 |
81 | B cell mediated immunity (GO:0019724) | 2.64284138 |
82 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.62724706 |
83 | regulation of mast cell degranulation (GO:0043304) | 2.61468247 |
84 | positive regulation of B cell proliferation (GO:0030890) | 2.60711250 |
85 | mature B cell differentiation (GO:0002335) | 2.60002294 |
86 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.59582267 |
87 | T cell migration (GO:0072678) | 2.59402327 |
88 | negative regulation of response to biotic stimulus (GO:0002832) | 2.58579445 |
89 | histone H3-K4 trimethylation (GO:0080182) | 2.55146563 |
90 | negative regulation of phagocytosis (GO:0050765) | 2.54687407 |
91 | response to protozoan (GO:0001562) | 2.54479761 |
92 | programmed necrotic cell death (GO:0097300) | 2.53912107 |
93 | detection of external biotic stimulus (GO:0098581) | 2.51734794 |
94 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.50880150 |
95 | Peyers patch development (GO:0048541) | 2.50880150 |
96 | cytoplasmic pattern recognition receptor signaling pathway (GO:0002753) | 2.50705156 |
97 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.49080896 |
98 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.48420346 |
99 | negative regulation of B cell proliferation (GO:0030889) | 2.47304335 |
100 | regulation of interferon-beta production (GO:0032648) | 2.44437802 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MYC_22102868_ChIP-Seq_BL_Human | 4.08187490 |
2 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.98012385 |
3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.77078907 |
4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.35266695 |
5 | MAF_26560356_Chip-Seq_TH1_Human | 2.65171765 |
6 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.57708059 |
7 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.54161453 |
8 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.49836920 |
9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.42081495 |
10 | MAF_26560356_Chip-Seq_TH2_Human | 2.35026596 |
11 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.32065748 |
12 | UTX_26944678_Chip-Seq_JUKART_Human | 2.20730020 |
13 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.19874139 |
14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.16441454 |
15 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.14294304 |
16 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.11097255 |
17 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.09220015 |
18 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.08159066 |
19 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.05632192 |
20 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.00544746 |
21 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.98357911 |
22 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.96299447 |
23 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.90967117 |
24 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.89869063 |
25 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81196142 |
26 | MYB_26560356_Chip-Seq_TH1_Human | 1.80215323 |
27 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.80092665 |
28 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.77785034 |
29 | MYB_26560356_Chip-Seq_TH2_Human | 1.75412917 |
30 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.74764415 |
31 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.73091137 |
32 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.68302784 |
33 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.67837539 |
34 | P68_20966046_ChIP-Seq_HELA_Human | 1.63876792 |
35 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.61928886 |
36 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.60611410 |
37 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.58159315 |
38 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.55984158 |
39 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.53958846 |
40 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.52733222 |
41 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.51277154 |
42 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.50547529 |
43 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.49403940 |
44 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.47364767 |
45 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.47007017 |
46 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.44767249 |
47 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.40831075 |
48 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.39335984 |
49 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39057156 |
50 | SPI1_23127762_ChIP-Seq_K562_Human | 1.37705518 |
51 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.37551784 |
52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35619272 |
53 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.35155939 |
54 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34268772 |
55 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.34231346 |
56 | GATA1_22025678_ChIP-Seq_K562_Human | 1.33423847 |
57 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.31831163 |
58 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.31091664 |
59 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.30451705 |
60 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.27885167 |
61 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.26143949 |
62 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.24956620 |
63 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.24227589 |
64 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.22379992 |
65 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.22123469 |
66 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.21992418 |
67 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.20744629 |
68 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.20073711 |
69 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.17999250 |
70 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.17802185 |
71 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.17501282 |
72 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.16258087 |
73 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.15818733 |
74 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.15720276 |
75 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.14527018 |
76 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.14396422 |
77 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.11472223 |
78 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.11369099 |
79 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.10969665 |
80 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.09606045 |
81 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.09557006 |
82 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.09423514 |
83 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.08068503 |
84 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.07996961 |
85 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.06591134 |
86 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.05538942 |
87 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.04643972 |
88 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.03347333 |
89 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02454647 |
90 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.02299869 |
91 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01789867 |
92 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.00972501 |
93 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.00843177 |
94 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.98775462 |
95 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.98664037 |
96 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98634325 |
97 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.97890208 |
98 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.97538114 |
99 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.97380630 |
100 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.97115483 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001835_abnormal_antigen_presentation | 3.49955014 |
2 | MP0003763_abnormal_thymus_physiology | 3.25479459 |
3 | MP0001800_abnormal_humoral_immune | 3.12753567 |
4 | MP0000685_abnormal_immune_system | 3.12173852 |
5 | MP0003436_decreased_susceptibility_to | 3.10944301 |
6 | MP0003303_peritoneal_inflammation | 2.81343780 |
7 | MP0002396_abnormal_hematopoietic_system | 2.81294004 |
8 | MP0005671_abnormal_response_to | 2.78119704 |
9 | MP0001986_abnormal_taste_sensitivity | 2.77557599 |
10 | MP0008057_abnormal_DNA_replication | 2.58666854 |
11 | MP0004381_abnormal_hair_follicle | 2.58610612 |
12 | MP0001790_abnormal_immune_system | 2.56250413 |
13 | MP0005387_immune_system_phenotype | 2.56250413 |
14 | MP0005000_abnormal_immune_tolerance | 2.50799764 |
15 | MP0005174_abnormal_tail_pigmentation | 2.44396315 |
16 | MP0009278_abnormal_bone_marrow | 2.42175781 |
17 | MP0002723_abnormal_immune_serum | 2.40049923 |
18 | MP0002452_abnormal_antigen_presenting | 2.39736603 |
19 | MP0002420_abnormal_adaptive_immunity | 2.36744738 |
20 | MP0001819_abnormal_immune_cell | 2.35024965 |
21 | MP0002398_abnormal_bone_marrow | 2.34724542 |
22 | MP0010094_abnormal_chromosome_stability | 2.17945140 |
23 | MP0005025_abnormal_response_to | 2.17873379 |
24 | MP0005451_abnormal_body_composition | 2.10987088 |
25 | MP0000015_abnormal_ear_pigmentation | 2.09280303 |
26 | MP0009333_abnormal_splenocyte_physiolog | 2.06776590 |
27 | MP0000716_abnormal_immune_system | 2.04948050 |
28 | MP0002419_abnormal_innate_immunity | 2.00496122 |
29 | MP0003111_abnormal_nucleus_morphology | 1.92589636 |
30 | MP0000689_abnormal_spleen_morphology | 1.91702555 |
31 | MP0005409_darkened_coat_color | 1.89626178 |
32 | MP0002722_abnormal_immune_system | 1.85295575 |
33 | MP0002429_abnormal_blood_cell | 1.84392134 |
34 | MP0000703_abnormal_thymus_morphology | 1.80030874 |
35 | MP0003172_abnormal_lysosome_physiology | 1.73468927 |
36 | MP0004947_skin_inflammation | 1.70270786 |
37 | MP0002405_respiratory_system_inflammati | 1.62374165 |
38 | MP0005076_abnormal_cell_differentiation | 1.62090885 |
39 | MP0004808_abnormal_hematopoietic_stem | 1.56686424 |
40 | MP0002148_abnormal_hypersensitivity_rea | 1.55992747 |
41 | MP0002009_preneoplasia | 1.53427719 |
42 | MP0010155_abnormal_intestine_physiology | 1.51396658 |
43 | MP0008260_abnormal_autophagy | 1.50246328 |
44 | MP0009785_altered_susceptibility_to | 1.49653324 |
45 | MP0001873_stomach_inflammation | 1.46079783 |
46 | MP0002019_abnormal_tumor_incidence | 1.45913847 |
47 | MP0008007_abnormal_cellular_replicative | 1.45332493 |
48 | MP0005171_absent_coat_pigmentation | 1.42116107 |
49 | MP0002166_altered_tumor_susceptibility | 1.42020755 |
50 | MP0003077_abnormal_cell_cycle | 1.40884296 |
51 | MP0003724_increased_susceptibility_to | 1.34168311 |
52 | MP0001845_abnormal_inflammatory_respons | 1.31995373 |
53 | MP0005464_abnormal_platelet_physiology | 1.31558910 |
54 | MP0005083_abnormal_biliary_tract | 1.30387336 |
55 | MP0003693_abnormal_embryo_hatching | 1.25656075 |
56 | MP0003136_yellow_coat_color | 1.24951562 |
57 | MP0005310_abnormal_salivary_gland | 1.19381703 |
58 | MP0001545_abnormal_hematopoietic_system | 1.16890979 |
59 | MP0005397_hematopoietic_system_phenotyp | 1.16890979 |
60 | MP0005075_abnormal_melanosome_morpholog | 1.09975727 |
61 | MP0001853_heart_inflammation | 1.05063371 |
62 | MP0003300_gastrointestinal_ulcer | 1.03001183 |
63 | MP0003866_abnormal_defecation | 1.02772512 |
64 | MP0005423_abnormal_somatic_nervous | 0.99793714 |
65 | MP0004264_abnormal_extraembryonic_tissu | 0.98476746 |
66 | MP0003453_abnormal_keratinocyte_physiol | 0.97240974 |
67 | MP0004957_abnormal_blastocyst_morpholog | 0.96478352 |
68 | MP0002653_abnormal_ependyma_morphology | 0.91057079 |
69 | MP0000350_abnormal_cell_proliferation | 0.88922053 |
70 | MP0009840_abnormal_foam_cell | 0.86301888 |
71 | MP0000371_diluted_coat_color | 0.86213253 |
72 | MP0008469_abnormal_protein_level | 0.86192456 |
73 | MP0000313_abnormal_cell_death | 0.86004247 |
74 | MP0002006_tumorigenesis | 0.84938550 |
75 | MP0000490_abnormal_crypts_of | 0.84365151 |
76 | MP0000858_altered_metastatic_potential | 0.82896100 |
77 | MP0001533_abnormal_skeleton_physiology | 0.82555785 |
78 | MP0002132_abnormal_respiratory_system | 0.81901390 |
79 | MP0003828_pulmonary_edema | 0.81854208 |
80 | MP0003943_abnormal_hepatobiliary_system | 0.81589492 |
81 | MP0003191_abnormal_cellular_cholesterol | 0.78071730 |
82 | MP0005621_abnormal_cell_physiology | 0.77719035 |
83 | MP0005058_abnormal_lysosome_morphology | 0.77416869 |
84 | MP0008961_abnormal_basal_metabolism | 0.74939073 |
85 | MP0003705_abnormal_hypodermis_morpholog | 0.69514888 |
86 | MP0009764_decreased_sensitivity_to | 0.68411931 |
87 | MP0000465_gastrointestinal_hemorrhage | 0.66514115 |
88 | MP0006082_CNS_inflammation | 0.64873971 |
89 | MP0002933_joint_inflammation | 0.62889386 |
90 | MP0003656_abnormal_erythrocyte_physiolo | 0.61999964 |
91 | MP0001851_eye_inflammation | 0.61108053 |
92 | MP0009931_abnormal_skin_appearance | 0.60526054 |
93 | MP0008058_abnormal_DNA_repair | 0.59797994 |
94 | MP0006036_abnormal_mitochondrial_physio | 0.59306421 |
95 | MP0006035_abnormal_mitochondrial_morpho | 0.59120536 |
96 | MP0010307_abnormal_tumor_latency | 0.58760229 |
97 | MP0001663_abnormal_digestive_system | 0.58601525 |
98 | MP0002075_abnormal_coat/hair_pigmentati | 0.57902613 |
99 | MP0005384_cellular_phenotype | 0.57254299 |
100 | MP0000367_abnormal_coat/_hair | 0.55298930 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Agammaglobulinemia (HP:0004432) | 5.55045906 |
2 | Colitis (HP:0002583) | 4.19111886 |
3 | Cellulitis (HP:0100658) | 4.06430532 |
4 | Eczematoid dermatitis (HP:0000976) | 3.98670667 |
5 | Meningitis (HP:0001287) | 3.80752098 |
6 | Panhypogammaglobulinemia (HP:0003139) | 3.80523096 |
7 | Recurrent abscess formation (HP:0002722) | 3.69971345 |
8 | Recurrent cutaneous fungal infections (HP:0011370) | 3.66770070 |
9 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.66770070 |
10 | Recurrent fungal infections (HP:0002841) | 3.65807441 |
11 | Recurrent bacterial skin infections (HP:0005406) | 3.60289200 |
12 | Recurrent sinusitis (HP:0011108) | 3.53435718 |
13 | Recurrent viral infections (HP:0004429) | 3.53260854 |
14 | Pustule (HP:0200039) | 3.34246778 |
15 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.31929212 |
16 | Gastrointestinal inflammation (HP:0004386) | 3.28200911 |
17 | Chronic obstructive pulmonary disease (HP:0006510) | 3.21024190 |
18 | Obstructive lung disease (HP:0006536) | 3.21024190 |
19 | Verrucae (HP:0200043) | 3.20449144 |
20 | Papilloma (HP:0012740) | 3.20449144 |
21 | Inflammation of the large intestine (HP:0002037) | 3.19022187 |
22 | Gastrointestinal stroma tumor (HP:0100723) | 3.13023455 |
23 | Abnormality of the fingertips (HP:0001211) | 3.03988288 |
24 | Annular pancreas (HP:0001734) | 2.98446278 |
25 | Poikiloderma (HP:0001029) | 2.96950078 |
26 | Abnormality of macrophages (HP:0004311) | 2.93279530 |
27 | Mediastinal lymphadenopathy (HP:0100721) | 2.90725294 |
28 | Lymphopenia (HP:0001888) | 2.86283930 |
29 | Recurrent skin infections (HP:0001581) | 2.86152397 |
30 | Severe combined immunodeficiency (HP:0004430) | 2.79445911 |
31 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.76742861 |
32 | Viral hepatitis (HP:0006562) | 2.75211716 |
33 | Osteomyelitis (HP:0002754) | 2.73198444 |
34 | Intestinal fistula (HP:0100819) | 2.72036499 |
35 | Chronic diarrhea (HP:0002028) | 2.71586601 |
36 | Hemorrhage of the eye (HP:0011885) | 2.66144128 |
37 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.61078659 |
38 | Squamous cell carcinoma (HP:0002860) | 2.59533735 |
39 | Emphysema (HP:0002097) | 2.58010725 |
40 | Vasculitis (HP:0002633) | 2.54723896 |
41 | Sepsis (HP:0100806) | 2.54486661 |
42 | Birth length less than 3rd percentile (HP:0003561) | 2.52507436 |
43 | Rib fusion (HP:0000902) | 2.51748988 |
44 | Myositis (HP:0100614) | 2.49926427 |
45 | Gastrointestinal infarctions (HP:0005244) | 2.49814040 |
46 | Progressive external ophthalmoplegia (HP:0000590) | 2.49530477 |
47 | Recurrent pneumonia (HP:0006532) | 2.46744460 |
48 | Basal cell carcinoma (HP:0002671) | 2.46113169 |
49 | Encephalitis (HP:0002383) | 2.46014951 |
50 | Abnormality of T cell physiology (HP:0011840) | 2.42580252 |
51 | Granulocytopenia (HP:0001913) | 2.42450132 |
52 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.38828571 |
53 | Hypochromic anemia (HP:0001931) | 2.36175621 |
54 | Recurrent bronchitis (HP:0002837) | 2.35952178 |
55 | Lymphoma (HP:0002665) | 2.31369017 |
56 | Combined immunodeficiency (HP:0005387) | 2.30465471 |
57 | Recurrent lower respiratory tract infections (HP:0002783) | 2.30146580 |
58 | Chronic sinusitis (HP:0011109) | 2.29715592 |
59 | Abnormality of T cells (HP:0002843) | 2.29602161 |
60 | Increased IgE level (HP:0003212) | 2.28256845 |
61 | Rectal fistula (HP:0100590) | 2.27049789 |
62 | Rectovaginal fistula (HP:0000143) | 2.27049789 |
63 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.25911115 |
64 | Thin bony cortex (HP:0002753) | 2.20633263 |
65 | Chromsome breakage (HP:0040012) | 2.19991852 |
66 | Hypoplasia of the thymus (HP:0000778) | 2.18127073 |
67 | B lymphocytopenia (HP:0010976) | 2.17728963 |
68 | Prominent nose (HP:0000448) | 2.16857795 |
69 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.13336730 |
70 | Leukopenia (HP:0001882) | 2.12229460 |
71 | Stomatitis (HP:0010280) | 2.11955208 |
72 | Abnormality of B cell number (HP:0010975) | 2.11496780 |
73 | Testicular atrophy (HP:0000029) | 2.11352741 |
74 | Vaginal fistula (HP:0004320) | 2.11008443 |
75 | Breast hypoplasia (HP:0003187) | 2.10628636 |
76 | Facial hemangioma (HP:0000329) | 2.10342779 |
77 | Skin rash (HP:0000988) | 2.06767165 |
78 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.05019081 |
79 | Progressive muscle weakness (HP:0003323) | 2.03032244 |
80 | Sparse lateral eyebrow (HP:0005338) | 1.99774814 |
81 | IgM deficiency (HP:0002850) | 1.99350679 |
82 | Short chin (HP:0000331) | 1.99113894 |
83 | Prolonged bleeding time (HP:0003010) | 1.98169837 |
84 | Abnormality of the columella (HP:0009929) | 1.96746629 |
85 | Ulnar bowing (HP:0003031) | 1.96395630 |
86 | T lymphocytopenia (HP:0005403) | 1.96237588 |
87 | Easy fatigability (HP:0003388) | 1.95944706 |
88 | Hepatitis (HP:0012115) | 1.94724878 |
89 | Chest pain (HP:0100749) | 1.94564717 |
90 | Restrictive lung disease (HP:0002091) | 1.93107078 |
91 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.92539127 |
92 | Petechiae (HP:0000967) | 1.91376112 |
93 | Flat occiput (HP:0005469) | 1.90892914 |
94 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.90288160 |
95 | Recurrent otitis media (HP:0000403) | 1.89144774 |
96 | Absent thumb (HP:0009777) | 1.88430198 |
97 | Chronic otitis media (HP:0000389) | 1.87484304 |
98 | Epistaxis (HP:0000421) | 1.85694532 |
99 | Anorexia (HP:0002039) | 1.85321581 |
100 | Gingivitis (HP:0000230) | 1.84246116 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PDK2 | 4.26070863 |
2 | MAP4K1 | 4.20180564 |
3 | BLK | 3.55278195 |
4 | RIPK4 | 3.02228710 |
5 | TRIB3 | 2.68847105 |
6 | ERN1 | 2.66726164 |
7 | IRAK4 | 2.46976431 |
8 | SMG1 | 2.25762760 |
9 | CDK12 | 2.16026303 |
10 | GRK6 | 2.13600408 |
11 | MAP2K3 | 2.13368536 |
12 | PRPF4B | 2.01202232 |
13 | BTK | 1.89455020 |
14 | MAP3K10 | 1.83062893 |
15 | EEF2K | 1.78470929 |
16 | MAP3K13 | 1.77296589 |
17 | TESK2 | 1.74680840 |
18 | MAP3K14 | 1.72509715 |
19 | TYK2 | 1.68936923 |
20 | SYK | 1.66953871 |
21 | ZAP70 | 1.63605465 |
22 | CSF1R | 1.61352782 |
23 | TNK2 | 1.56287515 |
24 | SIK1 | 1.55328799 |
25 | SIK2 | 1.47450703 |
26 | CDK4 | 1.46781587 |
27 | TBK1 | 1.44882585 |
28 | JAK1 | 1.37841418 |
29 | TLK1 | 1.37752638 |
30 | MAPK12 | 1.35971738 |
31 | MAPK15 | 1.33174684 |
32 | MAP2K2 | 1.32135031 |
33 | HCK | 1.31411120 |
34 | ICK | 1.29886359 |
35 | NEK6 | 1.29137312 |
36 | JAK3 | 1.28767208 |
37 | IKBKE | 1.24777714 |
38 | MAPK11 | 1.21352717 |
39 | FES | 1.21091641 |
40 | MAPKAPK3 | 1.18972507 |
41 | IRAK2 | 1.18694298 |
42 | PDPK1 | 1.11685896 |
43 | CSK | 1.11088089 |
44 | IKBKB | 0.99026995 |
45 | MAPK7 | 0.97581964 |
46 | LYN | 0.96709468 |
47 | PDK1 | 0.93404998 |
48 | SIK3 | 0.86972441 |
49 | ITK | 0.85751402 |
50 | CDK6 | 0.85651852 |
51 | HIPK2 | 0.81628516 |
52 | MAP3K7 | 0.79989081 |
53 | MARK2 | 0.79279339 |
54 | TRIM28 | 0.77922010 |
55 | KIT | 0.77148940 |
56 | IRAK1 | 0.70928745 |
57 | LCK | 0.70852241 |
58 | PRKD2 | 0.69872441 |
59 | MAP3K11 | 0.69419768 |
60 | MELK | 0.68085153 |
61 | MARK3 | 0.65201010 |
62 | IRAK3 | 0.64525392 |
63 | MTOR | 0.61246590 |
64 | KSR2 | 0.57397888 |
65 | BMPR2 | 0.56441037 |
66 | MAP3K3 | 0.55870782 |
67 | PIM1 | 0.54723834 |
68 | MAP3K1 | 0.53699286 |
69 | RPS6KB2 | 0.53494728 |
70 | RPS6KC1 | 0.52937917 |
71 | RPS6KL1 | 0.52937917 |
72 | ATR | 0.52903494 |
73 | MUSK | 0.52050442 |
74 | CAMK1D | 0.51596024 |
75 | STK10 | 0.49836190 |
76 | TEC | 0.48858055 |
77 | FGFR4 | 0.48058968 |
78 | PRKCQ | 0.47464524 |
79 | PKN2 | 0.47236736 |
80 | EPHB1 | 0.45628597 |
81 | RPS6KA6 | 0.45508796 |
82 | TXK | 0.44898682 |
83 | CDC42BPA | 0.44781812 |
84 | RAF1 | 0.43012035 |
85 | PASK | 0.42977646 |
86 | CHUK | 0.42440479 |
87 | LRRK2 | 0.42359435 |
88 | PIK3CG | 0.42338968 |
89 | KDR | 0.40558669 |
90 | MAP3K8 | 0.39908043 |
91 | ZAK | 0.39778429 |
92 | JAK2 | 0.39725487 |
93 | NEK2 | 0.37406670 |
94 | PIM2 | 0.36908348 |
95 | CAMKK1 | 0.36364789 |
96 | NME2 | 0.35000644 |
97 | MAP2K6 | 0.32616255 |
98 | MAPKAPK2 | 0.32511818 |
99 | DAPK1 | 0.29405999 |
100 | CDC7 | 0.29167599 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.71864386 |
2 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.22296945 |
3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.15297562 |
4 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 2.10714409 |
5 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.01722727 |
6 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.01454627 |
7 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 2.00195756 |
8 | Allograft rejection_Homo sapiens_hsa05330 | 1.93789171 |
9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.84020909 |
10 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.80396046 |
11 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.73500131 |
12 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.72538452 |
13 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.69714093 |
14 | DNA replication_Homo sapiens_hsa03030 | 1.69573094 |
15 | Other glycan degradation_Homo sapiens_hsa00511 | 1.64998526 |
16 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.64297351 |
17 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.63579634 |
18 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.59945710 |
19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.55629500 |
20 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.52538125 |
21 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.50027455 |
22 | Asthma_Homo sapiens_hsa05310 | 1.49876813 |
23 | Tuberculosis_Homo sapiens_hsa05152 | 1.48795129 |
24 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.48731742 |
25 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.44443654 |
26 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.43912528 |
27 | Influenza A_Homo sapiens_hsa05164 | 1.43894532 |
28 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.43122812 |
29 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.40906155 |
30 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.38936909 |
31 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.35854865 |
32 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.35316090 |
33 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.35061961 |
34 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.34447618 |
35 | Measles_Homo sapiens_hsa05162 | 1.33557927 |
36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.31941073 |
37 | Hepatitis B_Homo sapiens_hsa05161 | 1.28938222 |
38 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.27080303 |
39 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.26755553 |
40 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.23381394 |
41 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.22472513 |
42 | Homologous recombination_Homo sapiens_hsa03440 | 1.21321696 |
43 | Viral myocarditis_Homo sapiens_hsa05416 | 1.18813605 |
44 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.18208818 |
45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.15721357 |
46 | Base excision repair_Homo sapiens_hsa03410 | 1.13337208 |
47 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.11889141 |
48 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.10800312 |
49 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.09956361 |
50 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.04822893 |
51 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.02630791 |
52 | Hepatitis C_Homo sapiens_hsa05160 | 1.01670879 |
53 | Apoptosis_Homo sapiens_hsa04210 | 1.00880491 |
54 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.99860123 |
55 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.98950953 |
56 | HTLV-I infection_Homo sapiens_hsa05166 | 0.97877917 |
57 | Endometrial cancer_Homo sapiens_hsa05213 | 0.93614864 |
58 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.92938979 |
59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.91686047 |
60 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.89062746 |
61 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.83461177 |
62 | Colorectal cancer_Homo sapiens_hsa05210 | 0.82937641 |
63 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.79650526 |
64 | Insulin resistance_Homo sapiens_hsa04931 | 0.75798400 |
65 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73936658 |
66 | Legionellosis_Homo sapiens_hsa05134 | 0.72997519 |
67 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.70809359 |
68 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.68145031 |
69 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.67358121 |
70 | Platelet activation_Homo sapiens_hsa04611 | 0.67090514 |
71 | Prostate cancer_Homo sapiens_hsa05215 | 0.64525436 |
72 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.64395128 |
73 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.64386411 |
74 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.61172372 |
75 | Lysine degradation_Homo sapiens_hsa00310 | 0.60319065 |
76 | Cell cycle_Homo sapiens_hsa04110 | 0.59033743 |
77 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.59010572 |
78 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.58663869 |
79 | Bladder cancer_Homo sapiens_hsa05219 | 0.57004541 |
80 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.56230117 |
81 | Galactose metabolism_Homo sapiens_hsa00052 | 0.56100589 |
82 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.55780281 |
83 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.55560353 |
84 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.54783614 |
85 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.54668496 |
86 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.54170447 |
87 | Shigellosis_Homo sapiens_hsa05131 | 0.53214274 |
88 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.51331918 |
89 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.49902074 |
90 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.48550911 |
91 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.47930662 |
92 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.46978239 |
93 | Alcoholism_Homo sapiens_hsa05034 | 0.45921307 |
94 | Malaria_Homo sapiens_hsa05144 | 0.44256067 |
95 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.43622233 |
96 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.41108440 |
97 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.41006995 |
98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.40846791 |
99 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.40210534 |
100 | Mismatch repair_Homo sapiens_hsa03430 | 0.40058277 |