ILDR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains an immunoglobulin-like domain. The encoded protein may function as a multimeric receptor at the cell surface. The expression of this gene may be a diagnostic marker for cancer progression. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.51995118
2cilium or flagellum-dependent cell motility (GO:0001539)8.25065367
3COPI coating of Golgi vesicle (GO:0048205)7.70679101
4Golgi transport vesicle coating (GO:0048200)7.70679101
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.53416621
6intestinal epithelial cell development (GO:0060576)7.16377009
7cilium movement (GO:0003341)7.08830248
8epithelial cilium movement (GO:0003351)6.91615891
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.87327289
10axoneme assembly (GO:0035082)5.81532986
11UDP-N-acetylglucosamine metabolic process (GO:0006047)5.62277410
12motile cilium assembly (GO:0044458)5.44429702
13glandular epithelial cell differentiation (GO:0002067)5.37886713
14protein retention in ER lumen (GO:0006621)5.36582080
15GDP-mannose metabolic process (GO:0019673)5.25566862
16columnar/cuboidal epithelial cell development (GO:0002066)5.10758746
17endocrine pancreas development (GO:0031018)4.68074140
18nucleotide-sugar biosynthetic process (GO:0009226)4.57664123
19regulation of cilium movement (GO:0003352)4.29671111
20COPII vesicle coating (GO:0048208)4.16564873
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.15339699
223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.15339699
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.11337993
24negative regulation of keratinocyte proliferation (GO:0010839)4.09389036
25DNA deamination (GO:0045006)4.07658660
26cornea development in camera-type eye (GO:0061303)4.05752348
27bundle of His cell to Purkinje myocyte communication (GO:0086069)3.98132962
28intraciliary transport (GO:0042073)3.95467587
29fucose catabolic process (GO:0019317)3.92706527
30L-fucose metabolic process (GO:0042354)3.92706527
31L-fucose catabolic process (GO:0042355)3.92706527
32signal peptide processing (GO:0006465)3.79446353
33thyroid hormone generation (GO:0006590)3.76244609
34nucleotide-sugar metabolic process (GO:0009225)3.71338025
35peptide hormone processing (GO:0016486)3.66119174
36activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.66112479
37protein localization to cilium (GO:0061512)3.64710420
38cellular response to vitamin D (GO:0071305)3.62935223
39epithelial cell maturation (GO:0002070)3.61802704
40positive regulation of prostaglandin secretion (GO:0032308)3.61208168
41glandular epithelial cell development (GO:0002068)3.59673822
42cilium organization (GO:0044782)3.54254579
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.51501769
44interferon-gamma secretion (GO:0072643)3.50546966
45positive regulation of nuclease activity (GO:0032075)3.48518783
46protein maturation by protein folding (GO:0022417)3.48280348
47vitamin transmembrane transport (GO:0035461)3.46540784
48regulation of type B pancreatic cell apoptotic process (GO:2000674)3.42154306
49cilium assembly (GO:0042384)3.42104030
50keratinocyte development (GO:0003334)3.39499047
51proline biosynthetic process (GO:0006561)3.37676043
52retinal cone cell development (GO:0046549)3.36346511
53water-soluble vitamin biosynthetic process (GO:0042364)3.36062146
54thyroid hormone metabolic process (GO:0042403)3.34912876
55regulation of nuclease activity (GO:0032069)3.33636018
56diterpenoid biosynthetic process (GO:0016102)3.33511762
57calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.33185563
58multicellular organismal water homeostasis (GO:0050891)3.33037050
59left/right axis specification (GO:0070986)3.32600686
60piRNA metabolic process (GO:0034587)3.31897396
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.29560068
62exocrine pancreas development (GO:0031017)3.27416856
63signal transduction involved in regulation of gene expression (GO:0023019)3.26857955
64negative regulation of glycoprotein biosynthetic process (GO:0010561)3.26801716
65sphingoid metabolic process (GO:0046519)3.25424373
66photoreceptor cell maintenance (GO:0045494)3.25139361
67regulation of water loss via skin (GO:0033561)3.23193830
68sulfate transmembrane transport (GO:1902358)3.22864703
69maintenance of gastrointestinal epithelium (GO:0030277)3.22018091
70primary alcohol catabolic process (GO:0034310)3.19001902
71ventricular system development (GO:0021591)3.18280421
72regulation of apoptotic process involved in morphogenesis (GO:1902337)3.17811478
73auditory receptor cell differentiation (GO:0042491)3.17759503
74response to pheromone (GO:0019236)3.16951742
75cellular ketone body metabolic process (GO:0046950)3.15125355
76endoplasmic reticulum unfolded protein response (GO:0030968)3.14242580
77phosphatidylserine acyl-chain remodeling (GO:0036150)3.13993149
78multicellular organism reproduction (GO:0032504)3.13130706
79type B pancreatic cell development (GO:0003323)3.12654957
80hepatocyte apoptotic process (GO:0097284)3.12233045
81phosphatidylinositol acyl-chain remodeling (GO:0036149)3.09743162
82trophectodermal cell differentiation (GO:0001829)3.07767832
83cellular response to unfolded protein (GO:0034620)3.07663200
84ear development (GO:0043583)3.06905104
85establishment of apical/basal cell polarity (GO:0035089)3.05614556
86positive regulation of epidermal cell differentiation (GO:0045606)3.04508252
87cellular response to topologically incorrect protein (GO:0035967)3.03633383
88ethanol metabolic process (GO:0006067)3.03129988
89pyrimidine-containing compound transmembrane transport (GO:0072531)3.01854779
90one-carbon compound transport (GO:0019755)3.01264303
91positive regulation of icosanoid secretion (GO:0032305)3.00091718
92mannosylation (GO:0097502)2.99535294
93cilium morphogenesis (GO:0060271)2.98937360
94ER overload response (GO:0006983)2.97436427
95diol metabolic process (GO:0034311)2.96122130
96folic acid-containing compound biosynthetic process (GO:0009396)2.94713906
97response to hepatocyte growth factor (GO:0035728)2.94017127
98cellular response to hepatocyte growth factor stimulus (GO:0035729)2.94017127
99glutathione derivative biosynthetic process (GO:1901687)2.92289197
100glutathione derivative metabolic process (GO:1901685)2.92289197
101microtubule bundle formation (GO:0001578)2.92182289
102protein N-linked glycosylation via asparagine (GO:0018279)2.90429134
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90179535
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.90179535
105positive regulation of fatty acid transport (GO:2000193)2.89852822
106branching involved in mammary gland duct morphogenesis (GO:0060444)2.89384599
107renal absorption (GO:0070293)2.88831891
108peptidyl-asparagine modification (GO:0018196)2.87098865
109cellular response to glucose starvation (GO:0042149)2.86906154
110positive regulation of insulin secretion (GO:0032024)2.85675311
111ER-nucleus signaling pathway (GO:0006984)2.84104172
112maintenance of protein localization in organelle (GO:0072595)2.83056616
113retinoic acid metabolic process (GO:0042573)2.82353088
114sulfate transport (GO:0008272)2.82044818
115desmosome organization (GO:0002934)2.81815919
116tight junction assembly (GO:0070830)2.81242936
117ketone body metabolic process (GO:1902224)2.81159525
118response to endoplasmic reticulum stress (GO:0034976)2.80728315
119regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.80572853
120negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.80538197
121exogenous drug catabolic process (GO:0042738)2.80123877
122muscle organ morphogenesis (GO:0048644)2.78946136
123protein autoprocessing (GO:0016540)2.78081411
124sequestering of metal ion (GO:0051238)2.77222894
125negative regulation of T cell differentiation in thymus (GO:0033085)2.76857757
126sulfur compound transport (GO:0072348)2.75708113
127embryonic camera-type eye morphogenesis (GO:0048596)2.75657166
128positive regulation of Cdc42 GTPase activity (GO:0043089)2.74987610
129nucleoside diphosphate phosphorylation (GO:0006165)2.73248407
130phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.72619652
131left/right pattern formation (GO:0060972)2.71351692
132cytidine metabolic process (GO:0046087)2.70679737
133cytidine catabolic process (GO:0006216)2.70679737
134cytidine deamination (GO:0009972)2.70679737
135establishment of monopolar cell polarity (GO:0061162)2.69829779
136establishment or maintenance of monopolar cell polarity (GO:0061339)2.69829779
137sphingosine metabolic process (GO:0006670)2.69790343
138terpenoid biosynthetic process (GO:0016114)2.69251651
139negative regulation of glycogen biosynthetic process (GO:0045719)2.68802173
140vesicle coating (GO:0006901)2.67839151
141regulation of microtubule-based movement (GO:0060632)2.67831745
142regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.67686111
143regulation of keratinocyte proliferation (GO:0010837)2.66805820
144negative regulation by host of viral transcription (GO:0043922)2.65935260
145centriole assembly (GO:0098534)2.65364992
146drug catabolic process (GO:0042737)2.64308177
147regulation of Golgi to plasma membrane protein transport (GO:0042996)2.64273309
148water homeostasis (GO:0030104)2.64201967
149sperm motility (GO:0030317)2.63335729
150O-glycan processing (GO:0016266)2.63328747
151negative regulation of insulin secretion (GO:0046676)2.62631520
152negative regulation of bone resorption (GO:0045779)2.61649845
153protein N-linked glycosylation (GO:0006487)2.60789423
154flavonoid metabolic process (GO:0009812)2.59702102
155regulation of chemokine secretion (GO:0090196)2.59504580
156nucleotide transmembrane transport (GO:1901679)2.58334115
157benzene-containing compound metabolic process (GO:0042537)2.57418235
158adult feeding behavior (GO:0008343)2.55599271
159cellular response to vitamin (GO:0071295)2.55368893
160hemidesmosome assembly (GO:0031581)2.55237779
161cellular component assembly involved in morphogenesis (GO:0010927)2.55098841
162indolalkylamine metabolic process (GO:0006586)2.55096265
163hair cell differentiation (GO:0035315)2.54242807
164regulation of meiosis I (GO:0060631)2.53344007
165short-chain fatty acid metabolic process (GO:0046459)2.52410224
166photoreceptor cell development (GO:0042461)2.52348455
167pyrimidine ribonucleoside catabolic process (GO:0046133)2.49891302
168DNA methylation involved in gamete generation (GO:0043046)2.47865386
169negative regulation of kidney development (GO:0090185)2.47330487
170excretion (GO:0007588)2.47179965
171retinol metabolic process (GO:0042572)2.47038744
172regulation of prostaglandin secretion (GO:0032306)2.46999382
173regulation of acrosome reaction (GO:0060046)2.46223698
174phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.44444687
175phenol-containing compound catabolic process (GO:0019336)2.43850271
176autophagic vacuole fusion (GO:0000046)2.43467915
177regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.42199655
178glycerophospholipid catabolic process (GO:0046475)2.41209762
179detection of light stimulus involved in visual perception (GO:0050908)2.41038498
180detection of light stimulus involved in sensory perception (GO:0050962)2.41038498
181organic cation transport (GO:0015695)2.39093420
182centriole replication (GO:0007099)2.35631036
183cell projection assembly (GO:0030031)2.34027037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.77376692
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.77376692
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.77376692
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.57038828
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.71045707
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51634508
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38988101
8ZNF274_21170338_ChIP-Seq_K562_Hela3.12084132
9VDR_22108803_ChIP-Seq_LS180_Human3.08575703
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.96543341
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.90823380
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.76543283
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.70847465
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.69915149
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.63047577
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.50145711
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.45901006
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35172517
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.31230889
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.30539849
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.21481514
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.20152489
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17181769
24GATA6_25053715_ChIP-Seq_YYC3_Human2.16211748
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.13214563
26TCF3_18692474_ChIP-Seq_MESCs_Mouse2.11183691
27ER_23166858_ChIP-Seq_MCF-7_Human2.09903540
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.06358222
29EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01313247
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00311875
31NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.00067062
32* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97612477
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96878096
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94572196
35GATA4_25053715_ChIP-Seq_YYC3_Human1.89785108
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88070347
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86438966
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.85803956
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.85803956
40BCAT_22108803_ChIP-Seq_LS180_Human1.85193522
41AHR_22903824_ChIP-Seq_MCF-7_Human1.82347272
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76917889
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73893617
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.73814391
45* SOX2_20726797_ChIP-Seq_SW620_Human1.72250072
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71651476
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68435343
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67590441
49HOXB7_26014856_ChIP-Seq_BT474_Human1.67493259
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.67201318
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.67185200
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62386600
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.60772458
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60593767
55AR_20517297_ChIP-Seq_VCAP_Human1.54956332
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.54631813
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.53936857
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53852859
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52121880
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51181537
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49795669
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49279521
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47413930
64CDX2_22108803_ChIP-Seq_LS180_Human1.47216167
65FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46814644
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.46784288
67EWS_26573619_Chip-Seq_HEK293_Human1.46056982
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.45694071
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45195063
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.45082408
71* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44768911
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.43982706
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.43916006
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42996332
75NANOG_19829295_ChIP-Seq_ESCs_Human1.40985273
76SOX2_19829295_ChIP-Seq_ESCs_Human1.40985273
77IGF1R_20145208_ChIP-Seq_DFB_Human1.40572316
78KAP1_27257070_Chip-Seq_ESCs_Mouse1.40018814
79TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38671659
80TCF4_22108803_ChIP-Seq_LS180_Human1.35539538
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35262577
82NANOG_18692474_ChIP-Seq_MESCs_Mouse1.35137510
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34787467
84* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32664575
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.31910000
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31169194
87GBX2_23144817_ChIP-Seq_PC3_Human1.30910283
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30290378
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29262337
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.26558277
91NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26224938
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26207579
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23569719
94STAT3_23295773_ChIP-Seq_U87_Human1.23471659
95CEBPB_22108803_ChIP-Seq_LS180_Human1.21799812
96SMRT_27268052_Chip-Seq_Bcells_Human1.21765770
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.20282460
98NCOR_22424771_ChIP-Seq_293T_Human1.19301205
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19165398
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17286093
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17247570
102RACK7_27058665_Chip-Seq_MCF-7_Human1.16906911
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14795535
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14479605
105TP53_22573176_ChIP-Seq_HFKS_Human1.13992318
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13658827
107ELF5_23300383_ChIP-Seq_T47D_Human1.13446347
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13303447
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13124675
110TFEB_21752829_ChIP-Seq_HELA_Human1.12816657
111* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12247362
112AR_25329375_ChIP-Seq_VCAP_Human1.11789730
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11706083
114STAT1_20625510_ChIP-Seq_HELA_Human1.10627700
115NANOG_21062744_ChIP-ChIP_HESCs_Human1.10348694
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.08528207
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08363769
118SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08357544
119RBPJ_21746931_ChIP-Seq_IB4_Human1.08175291
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07995666
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07639029
122SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07581277
123DROSHA_22980978_ChIP-Seq_HELA_Human1.07104055
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05500574
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.04918778
126TP63_19390658_ChIP-ChIP_HaCaT_Human1.04659466
127P300_19829295_ChIP-Seq_ESCs_Human1.04063865
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02624582
129* TCF4_23295773_ChIP-Seq_U87_Human1.02534490
130PHF8_20622853_ChIP-Seq_HELA_Human1.02417747
131KLF5_25053715_ChIP-Seq_YYC3_Human1.02342315
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02314553
133ETV1_20927104_ChIP-Seq_GIST48_Human1.01670030
134PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00959561
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00729411
136CBP_20019798_ChIP-Seq_JUKART_Human1.00729411
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99541479
138ATF3_27146783_Chip-Seq_COLON_Human0.99411799
139FOXH1_21741376_ChIP-Seq_ESCs_Human0.99011192
140TP63_23658742_ChIP-Seq_EP156T_Human0.98990267
141P53_21459846_ChIP-Seq_SAOS-2_Human0.98620710
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98004940
143CHD1_26751641_Chip-Seq_LNCaP_Human0.97813222
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97603097
145GABP_17652178_ChIP-ChIP_JURKAT_Human0.96596396
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96565954
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96483403
148RUNX2_22187159_ChIP-Seq_PCA_Human0.96416400
149E2F7_22180533_ChIP-Seq_HELA_Human0.96029319
150HNFA_21074721_ChIP-Seq_CACO-2_Human0.96028041
151GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95934693
152* NANOG_16518401_ChIP-PET_MESCs_Mouse0.94848187
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94678607
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.94607349
155CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94375837
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.94335049
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93778593
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93732703
159GATA6_21074721_ChIP-Seq_CACO-2_Human0.93701068
160OCT4_20526341_ChIP-Seq_ESCs_Human0.93481725
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93001704
162GATA1_22025678_ChIP-Seq_K562_Human0.92602847
163TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91602064
164MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91440447
165CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90772589
166IRF1_19129219_ChIP-ChIP_H3396_Human0.90536160
167NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89581587
168KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88391962
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.87964419
170FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87728527
171ELK1_22589737_ChIP-Seq_MCF10A_Human0.87657193
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87460221
173POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86857802
174ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86419264
175SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85302960
176SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85302960
177GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83602981
178KDM5A_27292631_Chip-Seq_BREAST_Human0.82651067
179SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82595378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.68141964
2MP0003283_abnormal_digestive_organ4.64395292
3MP0004264_abnormal_extraembryonic_tissu4.38502424
4MP0004043_abnormal_pH_regulation3.99201820
5MP0008875_abnormal_xenobiotic_pharmacok3.66566444
6MP0002877_abnormal_melanocyte_morpholog3.15971749
7MP0000678_abnormal_parathyroid_gland3.15230382
8MP0003878_abnormal_ear_physiology2.71492236
9MP0005377_hearing/vestibular/ear_phenot2.71492236
10MP0000383_abnormal_hair_follicle2.57307063
11MP0000462_abnormal_digestive_system2.48805346
12MP0010386_abnormal_urinary_bladder2.40180329
13MP0010352_gastrointestinal_tract_polyps2.34665668
14MP0005310_abnormal_salivary_gland2.21215604
15MP0002693_abnormal_pancreas_physiology2.18665243
16MP0000613_abnormal_salivary_gland2.16081440
17MP0003693_abnormal_embryo_hatching2.14288325
18MP0008872_abnormal_physiological_respon2.13516128
19MP0003866_abnormal_defecation2.03868130
20MP0002653_abnormal_ependyma_morphology2.03861786
21MP0001944_abnormal_pancreas_morphology1.97233820
22MP0000427_abnormal_hair_cycle1.94654769
23MP0003195_calcinosis1.91915524
24MP0003183_abnormal_peptide_metabolism1.88755212
25MP0002160_abnormal_reproductive_system1.85998998
26MP0002138_abnormal_hepatobiliary_system1.85678158
27MP0001765_abnormal_ion_homeostasis1.80842170
28MP0003941_abnormal_skin_development1.78053907
29MP0005551_abnormal_eye_electrophysiolog1.76665072
30MP0005220_abnormal_exocrine_pancreas1.72925125
31MP0000516_abnormal_urinary_system1.69714393
32MP0005367_renal/urinary_system_phenotyp1.69714393
33MP0002277_abnormal_respiratory_mucosa1.67819161
34MP0008995_early_reproductive_senescence1.59727804
35MP0000490_abnormal_crypts_of1.59657277
36MP0005379_endocrine/exocrine_gland_phen1.59168995
37MP0002909_abnormal_adrenal_gland1.58227421
38MP0003252_abnormal_bile_duct1.56883784
39MP0001346_abnormal_lacrimal_gland1.53717703
40MP0002139_abnormal_hepatobiliary_system1.51735869
41MP0009643_abnormal_urine_homeostasis1.49978361
42MP0000013_abnormal_adipose_tissue1.48642532
43MP0002837_dystrophic_cardiac_calcinosis1.48031844
44MP0004957_abnormal_blastocyst_morpholog1.47601245
45MP0009780_abnormal_chondrocyte_physiolo1.45857888
46MP0005389_reproductive_system_phenotype1.45036300
47MP0004782_abnormal_surfactant_physiolog1.40567975
48MP0001849_ear_inflammation1.38964455
49MP0005085_abnormal_gallbladder_physiolo1.38860264
50MP0003890_abnormal_embryonic-extraembry1.34907921
51MP0005387_immune_system_phenotype1.33806207
52MP0001790_abnormal_immune_system1.33806207
53MP0002102_abnormal_ear_morphology1.33250966
54MP0003943_abnormal_hepatobiliary_system1.32707064
55MP0000566_synostosis1.30630605
56MP0002168_other_aberrant_phenotype1.29679249
57MP0001756_abnormal_urination1.28793975
58MP0002098_abnormal_vibrissa_morphology1.28674185
59MP0002009_preneoplasia1.27466892
60MP0004147_increased_porphyrin_level1.27264274
61MP0001501_abnormal_sleep_pattern1.25335451
62MP0005410_abnormal_fertilization1.24440492
63MP0000477_abnormal_intestine_morphology1.24284576
64MP0001873_stomach_inflammation1.23636848
65MP0003119_abnormal_digestive_system1.22144039
66MP0000685_abnormal_immune_system1.21333404
67MP0006072_abnormal_retinal_apoptosis1.20838690
68MP0006292_abnormal_olfactory_placode1.19531584
69MP0005381_digestive/alimentary_phenotyp1.19046989
70MP0002254_reproductive_system_inflammat1.18456686
71MP0002166_altered_tumor_susceptibility1.17510539
72MP0010678_abnormal_skin_adnexa1.16093627
73MP0003300_gastrointestinal_ulcer1.16037279
74MP0001764_abnormal_homeostasis1.15125760
75MP0010155_abnormal_intestine_physiology1.14324760
76MP0005671_abnormal_response_to1.12986847
77MP0000470_abnormal_stomach_morphology1.12534646
78MP0003566_abnormal_cell_adhesion1.12336586
79MP0005646_abnormal_pituitary_gland1.11737518
80MP0005365_abnormal_bile_salt1.11481448
81MP0005332_abnormal_amino_acid1.11176443
82MP0000762_abnormal_tongue_morphology1.10924230
83MP0001485_abnormal_pinna_reflex1.10778027
84MP0002896_abnormal_bone_mineralization1.10519786
85MP0005395_other_phenotype1.08391006
86MP0005083_abnormal_biliary_tract1.07812776
87MP0003786_premature_aging1.06648160
88MP0001881_abnormal_mammary_gland1.06504896
89MP0005248_abnormal_Harderian_gland1.06435513
90MP0000681_abnormal_thyroid_gland1.05533872
91MP0008789_abnormal_olfactory_epithelium1.03280390
92MP0003453_abnormal_keratinocyte_physiol1.02423584
93MP0002735_abnormal_chemical_nociception1.00016905
94MP0005636_abnormal_mineral_homeostasis0.98953616
95MP0005075_abnormal_melanosome_morpholog0.97950216
96MP0001929_abnormal_gametogenesis0.97032249
97MP0000003_abnormal_adipose_tissue0.96952950
98MP0003718_maternal_effect0.96418909
99MP0003698_abnormal_male_reproductive0.96166393
100MP0000538_abnormal_urinary_bladder0.96157476
101MP0002876_abnormal_thyroid_physiology0.95403472
102MP0001800_abnormal_humoral_immune0.95005286
103MP0009046_muscle_twitch0.94461601
104MP0008877_abnormal_DNA_methylation0.91771920
105MP0004133_heterotaxia0.90373411
106MP0005257_abnormal_intraocular_pressure0.90036960
107MP0005253_abnormal_eye_physiology0.89977622
108MP0002148_abnormal_hypersensitivity_rea0.88562809
109MP0000631_abnormal_neuroendocrine_gland0.86731562
110MP0001835_abnormal_antigen_presentation0.85876581
111MP0000537_abnormal_urethra_morphology0.85830265
112MP0001664_abnormal_digestion0.85748505
113MP0005076_abnormal_cell_differentiation0.84864444
114MP0000467_abnormal_esophagus_morphology0.84643824
115MP0001663_abnormal_digestive_system0.84593965
116MP0001145_abnormal_male_reproductive0.84425077
117MP0002928_abnormal_bile_duct0.84212989
118MP0003868_abnormal_feces_composition0.82179673
119MP0002078_abnormal_glucose_homeostasis0.79627574
120MP0004019_abnormal_vitamin_homeostasis0.79456243
121MP0002796_impaired_skin_barrier0.79439007
122MP0000653_abnormal_sex_gland0.79331455
123MP0005394_taste/olfaction_phenotype0.79063721
124MP0005499_abnormal_olfactory_system0.79063721
125MP0002136_abnormal_kidney_physiology0.78554345
126MP0001666_abnormal_nutrient_absorption0.78191376
127MP0006054_spinal_hemorrhage0.77986553
128MP0002006_tumorigenesis0.77655693
129MP0002234_abnormal_pharynx_morphology0.77589768
130MP0003879_abnormal_hair_cell0.76351872
131MP0001919_abnormal_reproductive_system0.74583014
132MP0002229_neurodegeneration0.74211742
133MP0003011_delayed_dark_adaptation0.74173650
134MP0001984_abnormal_olfaction0.74147995
135MP0003806_abnormal_nucleotide_metabolis0.73684118
136MP0008057_abnormal_DNA_replication0.73542861
137MP0002210_abnormal_sex_determination0.72886864
138MP0001324_abnormal_eye_pigmentation0.72276105
139MP0003045_fibrosis0.68828576
140MP0005645_abnormal_hypothalamus_physiol0.68149188
141MP0000579_abnormal_nail_morphology0.66958976
142MP0000627_abnormal_mammary_gland0.66427578
143MP0003936_abnormal_reproductive_system0.65632346
144MP0003953_abnormal_hormone_level0.65343835
145MP0002085_abnormal_embryonic_tissue0.64295133
146MP0002163_abnormal_gland_morphology0.63734828
147MP0002084_abnormal_developmental_patter0.61646143
148MP0000350_abnormal_cell_proliferation0.61010982
149MP0001348_abnormal_lacrimal_gland0.60943489
150MP0000163_abnormal_cartilage_morphology0.58800366
151MP0004885_abnormal_endolymph0.57443688
152MP0002086_abnormal_extraembryonic_tissu0.56631431

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.69877411
2Hyperactive renin-angiotensin system (HP:0000841)6.12038777
3Abnormal respiratory epithelium morphology (HP:0012253)6.01176251
4Abnormal respiratory motile cilium morphology (HP:0005938)6.01176251
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.00389551
6Absent/shortened dynein arms (HP:0200106)6.00389551
7Abnormal respiratory motile cilium physiology (HP:0012261)5.66295002
8Abnormal ciliary motility (HP:0012262)5.46166126
9Rhinitis (HP:0012384)5.30121313
10Bronchiectasis (HP:0002110)4.79969693
11Decreased circulating renin level (HP:0003351)4.66084739
12Abnormality of chloride homeostasis (HP:0011422)4.60529209
13Hyperinsulinemic hypoglycemia (HP:0000825)4.42603161
14Abnormality of renin-angiotensin system (HP:0000847)4.34381684
15Symptomatic seizures (HP:0011145)4.25682514
16Metabolic alkalosis (HP:0200114)4.15735441
17True hermaphroditism (HP:0010459)4.03817151
18Hypoglycemic seizures (HP:0002173)4.03284074
19Pancreatic cysts (HP:0001737)3.91376551
20Hyperaldosteronism (HP:0000859)3.86178875
21Hypokalemia (HP:0002900)3.82774652
22Pancreatic fibrosis (HP:0100732)3.71783165
23Bronchitis (HP:0012387)3.70404359
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.57829059
25Tetany (HP:0001281)3.49432322
26Nephronophthisis (HP:0000090)3.48531306
27Recurrent sinusitis (HP:0011108)3.42945233
28Chronic sinusitis (HP:0011109)3.37468979
29Unilateral renal agenesis (HP:0000122)3.31782577
30Tubular atrophy (HP:0000092)3.31052158
31Villous atrophy (HP:0011473)3.27077736
32Abnormality of small intestinal villus morphology (HP:0011472)3.27077736
33Molar tooth sign on MRI (HP:0002419)3.26219468
34Abnormality of midbrain morphology (HP:0002418)3.26219468
35Abnormality of the renal medulla (HP:0100957)3.24865143
36Hypoglycemic coma (HP:0001325)3.19459631
37Insulin-resistant diabetes mellitus (HP:0000831)3.19144277
38Cystic liver disease (HP:0006706)3.18266298
39Renal salt wasting (HP:0000127)3.11412629
40Aplasia/Hypoplasia of the fovea (HP:0008060)3.11024509
41Hypoplasia of the fovea (HP:0007750)3.11024509
42Onycholysis (HP:0001806)3.00178594
43Abdominal distention (HP:0003270)2.96090099
44Nasal polyposis (HP:0100582)2.92996533
45Abnormality of potassium homeostasis (HP:0011042)2.89117823
46Hyperglycemia (HP:0003074)2.89112166
47Right ventricular cardiomyopathy (HP:0011663)2.88695069
48Hyponatremia (HP:0002902)2.88223489
49Hypokalemic alkalosis (HP:0001949)2.83794060
50Congenital stationary night blindness (HP:0007642)2.83655442
51Abnormality of the renal cortex (HP:0011035)2.81691461
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.79455502
53Pendular nystagmus (HP:0012043)2.77139975
54Abnormal biliary tract morphology (HP:0012440)2.77038082
55Abnormal pancreas size (HP:0012094)2.69734631
56Hypomagnesemia (HP:0002917)2.63680703
57Shawl scrotum (HP:0000049)2.60322356
58Chronic bronchitis (HP:0004469)2.58942369
59Recurrent bronchitis (HP:0002837)2.52470668
60Congenital hepatic fibrosis (HP:0002612)2.49980364
61Pili torti (HP:0003777)2.49941969
62Lip pit (HP:0100267)2.49193642
63Chronic hepatic failure (HP:0100626)2.49096173
64Hyperphosphatemia (HP:0002905)2.47946347
65Biliary tract neoplasm (HP:0100574)2.46817176
66Recurrent otitis media (HP:0000403)2.46226330
67Osteomalacia (HP:0002749)2.43906394
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.41971113
69Decreased central vision (HP:0007663)2.40253262
70Increased circulating renin level (HP:0000848)2.38418627
71Asplenia (HP:0001746)2.36538558
72Gout (HP:0001997)2.35677267
73Furrowed tongue (HP:0000221)2.35211237
74Medial flaring of the eyebrow (HP:0010747)2.34614085
75Abnormality of the fovea (HP:0000493)2.33661895
76Hyperparathyroidism (HP:0000843)2.31501234
77Urinary glycosaminoglycan excretion (HP:0003541)2.31245853
78Mucopolysacchariduria (HP:0008155)2.31245853
79Large for gestational age (HP:0001520)2.31211478
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.29980495
81Abnormality of magnesium homeostasis (HP:0004921)2.29935879
82Alkalosis (HP:0001948)2.29932438
83Adrenal overactivity (HP:0002717)2.29723486
84Attenuation of retinal blood vessels (HP:0007843)2.29471732
85Abnormality of sodium homeostasis (HP:0010931)2.29452349
86Abnormality of the pancreatic islet cells (HP:0006476)2.28235846
87Abnormality of endocrine pancreas physiology (HP:0012093)2.28235846
88Male pseudohermaphroditism (HP:0000037)2.28112634
89Flat capital femoral epiphysis (HP:0003370)2.27926370
90Dehydration (HP:0001944)2.25160037
91Chronic otitis media (HP:0000389)2.25146839
92Abnormal rod and cone electroretinograms (HP:0008323)2.25124172
93Late onset (HP:0003584)2.24989559
94Abnormality of the nasal mucosa (HP:0000433)2.24981379
95Abnormality of macular pigmentation (HP:0008002)2.24970568
96Abnormality of polysaccharide metabolism (HP:0011012)2.24732510
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24732510
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24732510
99Amelogenesis imperfecta (HP:0000705)2.23552663
100Hypoplastic labia majora (HP:0000059)2.23160539
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21701343
102Exocrine pancreatic insufficiency (HP:0001738)2.21051626
103Tubulointerstitial nephritis (HP:0001970)2.19337034
104Postaxial foot polydactyly (HP:0001830)2.19248239
105Infertility (HP:0000789)2.17773265
106Short humerus (HP:0005792)2.16931117
107Vertebral hypoplasia (HP:0008417)2.16569727
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.16569727
109Polyuria (HP:0000103)2.15137663
110Type I transferrin isoform profile (HP:0003642)2.13530789
111Curly hair (HP:0002212)2.13396117
112Abnormality of renal excretion (HP:0011036)2.12216658
113Flat acetabular roof (HP:0003180)2.10506309
114Ketoacidosis (HP:0001993)2.09770095
115Hypoplasia of dental enamel (HP:0006297)2.09316555
116Gaze-evoked nystagmus (HP:0000640)2.08492417
117Intestinal atresia (HP:0011100)2.06390248
118Micronodular cirrhosis (HP:0001413)2.06014178
119Progressive sensorineural hearing impairment (HP:0000408)2.05232268
120Cheilitis (HP:0100825)2.04435375
121Aplasia/hypoplasia of the humerus (HP:0006507)2.02934713
122Pancreatic islet-cell hyperplasia (HP:0004510)2.02537248
123Vertebral clefting (HP:0008428)2.02067259
124Abnormality of the labia majora (HP:0012881)1.98145084
125Polydipsia (HP:0001959)1.97870098
126Abnormal drinking behavior (HP:0030082)1.97870098
127Tubulointerstitial fibrosis (HP:0005576)1.97615266
128Cone-rod dystrophy (HP:0000548)1.95761399
129Severe visual impairment (HP:0001141)1.95696506
130Anencephaly (HP:0002323)1.95535999
131Abnormal urine output (HP:0012590)1.94490900
132Vacuolated lymphocytes (HP:0001922)1.92743449
133Ependymoma (HP:0002888)1.92101505
134Dysostosis multiplex (HP:0000943)1.91035077
135Milia (HP:0001056)1.89752519
136Insulin resistance (HP:0000855)1.89237521
137Abnormality of the 1st metacarpal (HP:0010009)1.89114047
138Hypotension (HP:0002615)1.87629972
139Congenital sensorineural hearing impairment (HP:0008527)1.86656775
140Occipital encephalocele (HP:0002085)1.85023689
141Hyperglycinuria (HP:0003108)1.84589152
142Tubulointerstitial abnormality (HP:0001969)1.84340937
143Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.83629167
144Abnormal vertebral ossification (HP:0100569)1.82513904
145Abnormality of the salivary glands (HP:0010286)1.82259955
146Hyperkalemia (HP:0002153)1.80746707
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79572274
148Abnormal protein N-linked glycosylation (HP:0012347)1.79572274
149Abnormal protein glycosylation (HP:0012346)1.79572274
150Abnormal glycosylation (HP:0012345)1.79572274
151Thyroid-stimulating hormone excess (HP:0002925)1.78112413
152Generalized aminoaciduria (HP:0002909)1.77372934
153Widely patent fontanelles and sutures (HP:0004492)1.77344302
154Rib fusion (HP:0000902)1.75863025
155Missing ribs (HP:0000921)1.74118913
156Stage 5 chronic kidney disease (HP:0003774)1.72677511
157Abolished electroretinogram (ERG) (HP:0000550)1.72420605
158Agammaglobulinemia (HP:0004432)1.72336098
159Stomach cancer (HP:0012126)1.71379787
1603-Methylglutaconic aciduria (HP:0003535)1.71229368
161Sclerocornea (HP:0000647)1.71172312
162Nephrogenic diabetes insipidus (HP:0009806)1.68502688
163Congenital primary aphakia (HP:0007707)1.67675864
164Hypoplasia of the uterus (HP:0000013)1.65539569
165Concave nail (HP:0001598)1.59818832
166Abnormal biliary tract physiology (HP:0012439)1.58069567
167Bile duct proliferation (HP:0001408)1.58069567
168Ketosis (HP:0001946)1.57448757
169Gait imbalance (HP:0002141)1.56667439
170Increased corneal curvature (HP:0100692)1.56241835
171Keratoconus (HP:0000563)1.56241835
172Congenital, generalized hypertrichosis (HP:0004540)1.55877293
173Abnormality of the pons (HP:0007361)1.54115101
174Retinitis pigmentosa (HP:0000510)1.53828842
175Azoospermia (HP:0000027)1.53662052
176Abnormal albumin level (HP:0012116)1.50075290
177Hypoalbuminemia (HP:0003073)1.50075290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.48771195
2AKT34.59193651
3MAPK154.35360025
4ACVR1B3.80955990
5INSRR3.70221158
6PASK3.66953359
7BMPR1B3.51551807
8FRK3.38047605
9MST43.10437207
10MAP4K22.50310919
11BRSK22.48818928
12WNK32.43218214
13LATS12.22673978
14STK392.21828271
15TAOK32.17118071
16WNK42.08054862
17MAP2K21.97325961
18MUSK1.95332740
19HIPK21.92028437
20EPHA31.87249306
21MAP3K21.82213938
22PRKCI1.79884889
23MET1.78052140
24STK38L1.76763652
25ERN11.74041149
26CDK121.73657609
27RPS6KB21.67280055
28FLT31.62377709
29IRAK31.47342532
30TESK11.35396078
31DDR21.34646875
32FER1.33360224
33MAPKAPK31.28073563
34MST1R1.26357433
35BRAF1.25391577
36IKBKB1.17280319
37TTK1.15561435
38PTK21.14387456
39TGFBR11.11159924
40TLK11.06513423
41PKN21.03617158
42PRKCQ1.02241660
43STK240.98815012
44TNK20.96782981
45PAK40.92903027
46CDC42BPA0.90405957
47CHUK0.88331075
48PRKD20.87175331
49TNIK0.87119656
50PRKG20.86424812
51MATK0.86048901
52PIK3CA0.86009999
53NLK0.82156279
54CSK0.82084795
55EIF2AK30.78283158
56RIPK40.78224927
57BCKDK0.77966461
58PIK3CG0.77484112
59YES10.76669824
60MAP3K140.76312227
61GRK10.76020084
62NUAK10.75759789
63MAP4K10.74149297
64WEE10.73532173
65PTK60.73488258
66EPHB10.72653669
67JAK30.70188202
68DYRK1B0.69480015
69IKBKE0.68746809
70NME10.65631405
71KIT0.63284907
72IRAK40.63008324
73MAP3K30.62942994
74SIK30.60379112
75TBK10.60136070
76PDGFRA0.59917509
77ERBB30.59758703
78TXK0.59156924
79MAP3K10.58213055
80BRD40.57646513
81STK30.55930592
82ADRBK20.55745894
83MELK0.54842428
84TRPM70.54399671
85MAPKAPK50.54268453
86MYLK0.54089561
87MKNK20.53334389
88IRAK10.50271667
89MAP2K10.50100131
90OXSR10.49747677
91PRKAA20.49632579
92DYRK30.49234644
93ADRBK10.48369882
94STK100.47466707
95AURKB0.45700717
96BCR0.45411676
97SCYL20.44631356
98PINK10.44475789
99RPS6KA50.43963619
100VRK20.43278494
101CHEK20.43106514
102PDK10.42441997
103LMTK20.42313335
104NEK60.42034969
105TEC0.41969800
106TESK20.41701559
107CSF1R0.41454445
108MAPK130.41423301
109CSNK1A10.41047972
110ZAK0.41019420
111GSK3A0.40479646
112RIPK10.39314015
113PRKCD0.39087219
114MAP3K80.37703976
115CDK80.37631138
116PAK30.36778502
117ABL10.36709671
118SGK20.36693158
119PTK2B0.36385476
120PRKCZ0.36362705
121BMPR20.33574517
122SYK0.32890620
123BTK0.32296696
124PRKCH0.32105435
125TAOK10.31770443
126PRKD30.31563326
127WNK10.30275468
128PRKAA10.29677588
129SGK30.29537648
130PRKCE0.28865551
131RPS6KA40.28548206
132CDK70.28505795
133MAP2K60.27716286
134PRKCG0.26892532
135FGFR20.26518015
136TRIM280.26189554
137PRKCA0.25856254
138MAP3K70.25763241
139LRRK20.24828362
140MAP3K130.24717216
141LYN0.24475387
142MTOR0.24230898
143ITK0.24139555
144VRK10.23360852
145PIM10.23228172
146GRK60.21646818
147FGFR40.21360074
148NTRK10.19589754
149MAPKAPK20.18675932
150ERBB40.18230238
151CAMK2D0.17968203
152FGFR30.17920701
153TYK20.17688369
154RPS6KA10.16736348

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.04267781
2Sulfur metabolism_Homo sapiens_hsa009206.10982269
3Protein export_Homo sapiens_hsa030604.21727462
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.70904872
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.68482755
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.68083523
7Phototransduction_Homo sapiens_hsa047442.45566965
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.36468442
9Chemical carcinogenesis_Homo sapiens_hsa052042.32483416
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31227605
11Other glycan degradation_Homo sapiens_hsa005112.26561951
12Nitrogen metabolism_Homo sapiens_hsa009102.21443017
13Allograft rejection_Homo sapiens_hsa053302.00146226
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95120595
15Vibrio cholerae infection_Homo sapiens_hsa051101.94373993
16Butanoate metabolism_Homo sapiens_hsa006501.90524082
17Asthma_Homo sapiens_hsa053101.90484038
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89965764
19Mineral absorption_Homo sapiens_hsa049781.81969053
20Retinol metabolism_Homo sapiens_hsa008301.81034503
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.78591599
22Caffeine metabolism_Homo sapiens_hsa002321.77100077
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57086413
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56236829
25beta-Alanine metabolism_Homo sapiens_hsa004101.55620151
26Primary immunodeficiency_Homo sapiens_hsa053401.55032081
27Linoleic acid metabolism_Homo sapiens_hsa005911.49754507
28Graft-versus-host disease_Homo sapiens_hsa053321.49714357
29N-Glycan biosynthesis_Homo sapiens_hsa005101.48757837
30Fructose and mannose metabolism_Homo sapiens_hsa000511.47998124
31Tyrosine metabolism_Homo sapiens_hsa003501.44300208
32Selenocompound metabolism_Homo sapiens_hsa004501.43202347
33Insulin secretion_Homo sapiens_hsa049111.35228081
34Type I diabetes mellitus_Homo sapiens_hsa049401.25708154
35Galactose metabolism_Homo sapiens_hsa000521.24953268
36Folate biosynthesis_Homo sapiens_hsa007901.22550154
37Peroxisome_Homo sapiens_hsa041461.20455970
38Tight junction_Homo sapiens_hsa045301.20065611
39Mismatch repair_Homo sapiens_hsa034301.18184351
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17574263
41Adherens junction_Homo sapiens_hsa045201.16538753
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14029594
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12566772
44Lysosome_Homo sapiens_hsa041421.11108751
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.07001144
46Pancreatic secretion_Homo sapiens_hsa049721.04959542
47Sulfur relay system_Homo sapiens_hsa041221.04692991
48Arachidonic acid metabolism_Homo sapiens_hsa005901.03270285
49Circadian rhythm_Homo sapiens_hsa047101.01420395
50Bladder cancer_Homo sapiens_hsa052190.98594653
51Propanoate metabolism_Homo sapiens_hsa006400.96776277
52Thyroid cancer_Homo sapiens_hsa052160.94849960
53Huntingtons disease_Homo sapiens_hsa050160.93334340
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92376056
55Olfactory transduction_Homo sapiens_hsa047400.91856345
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91364331
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88497535
58Ovarian steroidogenesis_Homo sapiens_hsa049130.88253117
59Regulation of autophagy_Homo sapiens_hsa041400.85683290
60Antigen processing and presentation_Homo sapiens_hsa046120.82880454
61One carbon pool by folate_Homo sapiens_hsa006700.82845027
62Oxidative phosphorylation_Homo sapiens_hsa001900.80468939
63Protein digestion and absorption_Homo sapiens_hsa049740.80166557
64Prolactin signaling pathway_Homo sapiens_hsa049170.79162893
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78928819
66Sphingolipid metabolism_Homo sapiens_hsa006000.78085494
67Thyroid hormone synthesis_Homo sapiens_hsa049180.77427767
68Hippo signaling pathway_Homo sapiens_hsa043900.76364753
69Fatty acid degradation_Homo sapiens_hsa000710.76351354
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75142737
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74373344
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74256968
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72097698
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.69609278
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69420286
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.68213077
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.67058887
78Base excision repair_Homo sapiens_hsa034100.65242531
79Legionellosis_Homo sapiens_hsa051340.64861679
80Type II diabetes mellitus_Homo sapiens_hsa049300.64524407
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60704991
82Metabolic pathways_Homo sapiens_hsa011000.59970159
83Inositol phosphate metabolism_Homo sapiens_hsa005620.59808466
84Histidine metabolism_Homo sapiens_hsa003400.58158785
85Fanconi anemia pathway_Homo sapiens_hsa034600.57670580
86Collecting duct acid secretion_Homo sapiens_hsa049660.56753557
87Rheumatoid arthritis_Homo sapiens_hsa053230.55193000
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.52357084
89Notch signaling pathway_Homo sapiens_hsa043300.51960086
90Hepatitis C_Homo sapiens_hsa051600.50767489
91Fat digestion and absorption_Homo sapiens_hsa049750.50643367
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50622717
93Systemic lupus erythematosus_Homo sapiens_hsa053220.48958648
94Homologous recombination_Homo sapiens_hsa034400.48949873
95p53 signaling pathway_Homo sapiens_hsa041150.48443678
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.47483775
97RNA polymerase_Homo sapiens_hsa030200.47312748
98Taste transduction_Homo sapiens_hsa047420.47181003
99Endometrial cancer_Homo sapiens_hsa052130.46464417
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.45231973
101Prostate cancer_Homo sapiens_hsa052150.44412171
102Autoimmune thyroid disease_Homo sapiens_hsa053200.43384127
103Glutathione metabolism_Homo sapiens_hsa004800.41224884
104Basal transcription factors_Homo sapiens_hsa030220.40843772
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40225474
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39250526
107TGF-beta signaling pathway_Homo sapiens_hsa043500.38090343
108Non-homologous end-joining_Homo sapiens_hsa034500.37472495
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35952441
110Ether lipid metabolism_Homo sapiens_hsa005650.34555895
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34366113
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33512032
113Insulin resistance_Homo sapiens_hsa049310.33112910
114RNA degradation_Homo sapiens_hsa030180.33031378
115Renin-angiotensin system_Homo sapiens_hsa046140.31584416
116Tryptophan metabolism_Homo sapiens_hsa003800.31529743
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31359213
118Influenza A_Homo sapiens_hsa051640.31225603
119Starch and sucrose metabolism_Homo sapiens_hsa005000.30865515
120Phenylalanine metabolism_Homo sapiens_hsa003600.30835139
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30125086
122Salivary secretion_Homo sapiens_hsa049700.30029193
123Herpes simplex infection_Homo sapiens_hsa051680.28428174
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27981949
125Serotonergic synapse_Homo sapiens_hsa047260.27076781
126Dorso-ventral axis formation_Homo sapiens_hsa043200.26159932
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25353747
128RNA transport_Homo sapiens_hsa030130.25189506
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25127673
130Vitamin digestion and absorption_Homo sapiens_hsa049770.24965445
131Fatty acid elongation_Homo sapiens_hsa000620.24765318
132Purine metabolism_Homo sapiens_hsa002300.24741914
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24296214
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23823320
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23515947
136Small cell lung cancer_Homo sapiens_hsa052220.23055693
137Steroid biosynthesis_Homo sapiens_hsa001000.23018179
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22918435
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21792092
140Acute myeloid leukemia_Homo sapiens_hsa052210.21333286
141ABC transporters_Homo sapiens_hsa020100.20887083
142Pyrimidine metabolism_Homo sapiens_hsa002400.20407848
143Nucleotide excision repair_Homo sapiens_hsa034200.20331753
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19026116
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18771402
146Arginine and proline metabolism_Homo sapiens_hsa003300.17497555
147mRNA surveillance pathway_Homo sapiens_hsa030150.17294804
148TNF signaling pathway_Homo sapiens_hsa046680.17040146

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