ILF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sister chromatid segregation (GO:0000819)4.16748826
2nuclear pore complex assembly (GO:0051292)3.96956944
3ribosome assembly (GO:0042255)3.93316415
4IMP biosynthetic process (GO:0006188)3.87660229
5establishment of integrated proviral latency (GO:0075713)3.81783967
6purine nucleobase biosynthetic process (GO:0009113)3.79202112
7nuclear pore organization (GO:0006999)3.76388870
8protein localization to chromosome, centromeric region (GO:0071459)3.73633819
9mitotic chromosome condensation (GO:0007076)3.73186929
10central nervous system myelination (GO:0022010)3.63932768
11axon ensheathment in central nervous system (GO:0032291)3.63932768
12negative regulation of chromosome segregation (GO:0051985)3.60164774
13mitotic nuclear envelope disassembly (GO:0007077)3.59813716
14nucleobase biosynthetic process (GO:0046112)3.58629204
15negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.57124092
16negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.57124092
17negative regulation of mitotic sister chromatid segregation (GO:0033048)3.57124092
18negative regulation of mitotic sister chromatid separation (GO:2000816)3.57124092
19negative regulation of sister chromatid segregation (GO:0033046)3.57124092
20double-strand break repair via nonhomologous end joining (GO:0006303)3.56300654
21non-recombinational repair (GO:0000726)3.56300654
22microtubule depolymerization (GO:0007019)3.50410270
23establishment of chromosome localization (GO:0051303)3.50377219
24formation of translation preinitiation complex (GO:0001731)3.47948458
25mitotic spindle assembly checkpoint (GO:0007094)3.44693144
26regulation of chromosome segregation (GO:0051983)3.43077882
27positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41369463
28spindle assembly checkpoint (GO:0071173)3.39573020
29DNA ligation (GO:0006266)3.35676849
30IMP metabolic process (GO:0046040)3.35300705
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34254849
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34254849
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34254849
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32179639
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32179639
36regulation of cellular amino acid metabolic process (GO:0006521)3.32061119
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31358869
38nuclear envelope disassembly (GO:0051081)3.30080167
39membrane disassembly (GO:0030397)3.30080167
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28867029
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28867029
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28123012
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.28123012
44mitotic sister chromatid cohesion (GO:0007064)3.26820041
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.24759819
46regulation of ubiquitin-protein transferase activity (GO:0051438)3.24621075
47G1/S transition of mitotic cell cycle (GO:0000082)3.24518482
48cell cycle G1/S phase transition (GO:0044843)3.24518482
49positive regulation of ligase activity (GO:0051351)3.23987260
50regulation of sister chromatid segregation (GO:0033045)3.23650899
51regulation of mitotic sister chromatid separation (GO:0010965)3.23650899
52regulation of mitotic sister chromatid segregation (GO:0033047)3.23650899
53DNA catabolic process, exonucleolytic (GO:0000738)3.22372272
54CENP-A containing nucleosome assembly (GO:0034080)3.21498239
55regulation of centriole replication (GO:0046599)3.13715437
56chromatin remodeling at centromere (GO:0031055)3.13344460
57regulation of spindle organization (GO:0090224)3.12811774
58termination of RNA polymerase III transcription (GO:0006386)3.12555789
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.12555789
60regulation of ligase activity (GO:0051340)3.10620714
61RNA capping (GO:0036260)3.07494394
627-methylguanosine RNA capping (GO:0009452)3.07494394
63DNA replication initiation (GO:0006270)3.06929868
64ATP-dependent chromatin remodeling (GO:0043044)3.06226215
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05208968
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.05208968
67folic acid-containing compound biosynthetic process (GO:0009396)3.05016440
68kinetochore organization (GO:0051383)3.04765478
69establishment of viral latency (GO:0019043)3.04485783
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01965847
71microtubule polymerization or depolymerization (GO:0031109)3.01598397
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01578637
73proteasome assembly (GO:0043248)3.01361618
74DNA unwinding involved in DNA replication (GO:0006268)3.00981885
75spliceosomal complex assembly (GO:0000245)3.00404114
76DNA damage response, detection of DNA damage (GO:0042769)2.99440888
777-methylguanosine mRNA capping (GO:0006370)2.99190899
78protein neddylation (GO:0045116)2.98516824
79spliceosomal snRNP assembly (GO:0000387)2.95831770
80DNA strand elongation involved in DNA replication (GO:0006271)2.95602716
81energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90748734
82ATP synthesis coupled proton transport (GO:0015986)2.90748734
83cullin deneddylation (GO:0010388)2.88893019
84transcription elongation from RNA polymerase I promoter (GO:0006362)2.88773365
85kinetochore assembly (GO:0051382)2.88170270
86telomere maintenance via semi-conservative replication (GO:0032201)2.87645170
87presynaptic membrane assembly (GO:0097105)2.85072969
88DNA strand elongation (GO:0022616)2.84920662
89long-chain fatty acid biosynthetic process (GO:0042759)2.83928182
90ribosomal small subunit biogenesis (GO:0042274)2.83417021
91neuron cell-cell adhesion (GO:0007158)2.81817447
92limb bud formation (GO:0060174)2.80118736
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75260993
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75260993
95DNA replication-independent nucleosome organization (GO:0034724)2.73685406
96DNA replication-independent nucleosome assembly (GO:0006336)2.73685406
97presynaptic membrane organization (GO:0097090)2.73603493
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73046995
99chaperone-mediated protein transport (GO:0072321)2.69162758
100histone exchange (GO:0043486)2.66746643
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65992900
102establishment of protein localization to mitochondrial membrane (GO:0090151)2.65970975
103maturation of SSU-rRNA (GO:0030490)2.65346539
104transcription-coupled nucleotide-excision repair (GO:0006283)2.63257948
105viral mRNA export from host cell nucleus (GO:0046784)2.63069075
106histone H2B ubiquitination (GO:0033523)2.61464755
107histone H2A acetylation (GO:0043968)2.61192007
108termination of RNA polymerase I transcription (GO:0006363)2.60877275
109protein localization to kinetochore (GO:0034501)2.59589118
110protein deneddylation (GO:0000338)2.57508743
111DNA strand renaturation (GO:0000733)2.54220325
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.53681036
113mRNA splice site selection (GO:0006376)2.53329969
114mitotic recombination (GO:0006312)2.52472164
115negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51074557
116DNA replication checkpoint (GO:0000076)2.51044817
117telomere maintenance via recombination (GO:0000722)2.50109274
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.49663830
119positive regulation of histone H3-K4 methylation (GO:0051571)2.48746489
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47894585
121DNA replication-dependent nucleosome assembly (GO:0006335)2.47731874
122DNA replication-dependent nucleosome organization (GO:0034723)2.47731874
123telomere maintenance via telomere lengthening (GO:0010833)2.47616088
124mitotic sister chromatid segregation (GO:0000070)2.46682960
125DNA double-strand break processing (GO:0000729)2.45952378
126mitotic metaphase plate congression (GO:0007080)2.44560541
127negative regulation of ligase activity (GO:0051352)2.41535227
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.41535227
129DNA-templated transcription, termination (GO:0006353)2.40723603
130regulation of helicase activity (GO:0051095)2.39724085
131transcription from RNA polymerase I promoter (GO:0006360)2.39332253
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.39219649
133DNA-templated transcription, elongation (GO:0006354)2.38997328
134regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.38311136
135transcription elongation from RNA polymerase II promoter (GO:0006368)2.38239621
136centriole replication (GO:0007099)2.37185149
137spindle checkpoint (GO:0031577)2.36829839
138regulation of mRNA splicing, via spliceosome (GO:0048024)2.35272411
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.34937340
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.34937340
141NADH dehydrogenase complex assembly (GO:0010257)2.34937340
142RNA splicing, via transesterification reactions (GO:0000375)2.34936290
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.34785720
144mRNA splicing, via spliceosome (GO:0000398)2.34433978
145RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.34433978
146rRNA processing (GO:0006364)2.32834077
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.32707240
148mismatch repair (GO:0006298)2.32626638
149metaphase plate congression (GO:0051310)2.32601452
150negative regulation of DNA-dependent DNA replication (GO:2000104)2.32289980
151maturation of 5.8S rRNA (GO:0000460)2.31872303
152lateral sprouting from an epithelium (GO:0060601)2.31544140
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.30995059
154DNA topological change (GO:0006265)2.29740875
155DNA integration (GO:0015074)2.29187073
156mitotic spindle checkpoint (GO:0071174)2.28827223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60630740
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63762315
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54095634
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13614113
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11778881
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04146914
7EZH2_22144423_ChIP-Seq_EOC_Human2.92913910
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83181026
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69734286
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.65023321
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.51232427
12* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46330881
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37327880
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28323027
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26781215
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21785056
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.11467750
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09709234
19GBX2_23144817_ChIP-Seq_PC3_Human2.08816863
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08473288
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.04149515
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02505585
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95230881
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94423254
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89422092
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88002180
27FUS_26573619_Chip-Seq_HEK293_Human1.86187546
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82761581
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81010000
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78659628
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74477764
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72452736
33EWS_26573619_Chip-Seq_HEK293_Human1.72216924
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69519244
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64843132
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64479764
37* TP63_19390658_ChIP-ChIP_HaCaT_Human1.62209770
38TAF15_26573619_Chip-Seq_HEK293_Human1.60133422
39ELK1_19687146_ChIP-ChIP_HELA_Human1.59125784
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57177223
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.54921460
42VDR_23849224_ChIP-Seq_CD4+_Human1.54622730
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.53632402
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53212169
45IRF1_19129219_ChIP-ChIP_H3396_Human1.52986768
46* TTF2_22483619_ChIP-Seq_HELA_Human1.52881341
47* XRN2_22483619_ChIP-Seq_HELA_Human1.48818271
48KDM5A_27292631_Chip-Seq_BREAST_Human1.46123879
49* SOX2_16153702_ChIP-ChIP_HESCs_Human1.45870238
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.44856380
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43681708
52FOXP3_21729870_ChIP-Seq_TREG_Human1.42916459
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41205552
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40246900
55RNF2_27304074_Chip-Seq_NSC_Mouse1.38388721
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38368384
57* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32737514
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31154520
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30448224
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29564569
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26607811
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.23765597
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23335410
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22249564
65MYC_18940864_ChIP-ChIP_HL60_Human1.22043541
66VDR_22108803_ChIP-Seq_LS180_Human1.21668238
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19062492
68IGF1R_20145208_ChIP-Seq_DFB_Human1.18615760
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18055956
70DCP1A_22483619_ChIP-Seq_HELA_Human1.17580051
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17219047
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16040285
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15747801
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15557778
75* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15516535
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13339162
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11408448
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10991833
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10865491
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09865885
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08761063
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07771044
83* SRF_21415370_ChIP-Seq_HL-1_Mouse1.05864352
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05321832
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03961732
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03866792
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01903640
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01692656
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01325236
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01325236
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01325236
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.01170739
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.00843824
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99202891
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.97409899
96GABP_19822575_ChIP-Seq_HepG2_Human0.97067383
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96898339
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96804400
99CIITA_25753668_ChIP-Seq_RAJI_Human0.96504034
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94416383
101SOX9_26525672_Chip-Seq_HEART_Mouse0.93947494
102* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93388295
103* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93254290
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.93220298
105AR_21909140_ChIP-Seq_LNCAP_Human0.92264267
106* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91440439
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91160457
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91011377
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90763019
110ER_23166858_ChIP-Seq_MCF-7_Human0.90345586
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88684783
112P300_19829295_ChIP-Seq_ESCs_Human0.86756028
113* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86556777
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86403555
115* NANOG_16153702_ChIP-ChIP_HESCs_Human0.84953701
116EED_16625203_ChIP-ChIP_MESCs_Mouse0.84622367
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83946089
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83935347
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83825321
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82868327
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82812041
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81071076
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.79359789
124* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77395444
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77194798
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74361302
127TFEB_21752829_ChIP-Seq_HELA_Human0.73803403
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72699950
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72674581
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70155765
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.70022590
132* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.69933432
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69799308
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.68934694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.41565760
2MP0003880_abnormal_central_pattern3.24106070
3MP0006292_abnormal_olfactory_placode2.70477220
4MP0001529_abnormal_vocalization2.70331553
5MP0003718_maternal_effect2.55192376
6MP0010094_abnormal_chromosome_stability2.27609536
7MP0008058_abnormal_DNA_repair2.26744809
8MP0009697_abnormal_copulation2.26066362
9MP0008877_abnormal_DNA_methylation2.16299443
10MP0001730_embryonic_growth_arrest2.13336934
11MP0000566_synostosis2.09724042
12MP0003941_abnormal_skin_development2.08787784
13MP0002102_abnormal_ear_morphology2.08053908
14MP0005409_darkened_coat_color2.06192715
15MP0003121_genomic_imprinting2.05721057
16MP0003111_abnormal_nucleus_morphology2.00365714
17MP0001188_hyperpigmentation1.97318860
18MP0000778_abnormal_nervous_system1.97218410
19MP0000350_abnormal_cell_proliferation1.95340000
20MP0003136_yellow_coat_color1.92571772
21MP0005423_abnormal_somatic_nervous1.89368818
22MP0005171_absent_coat_pigmentation1.85223172
23MP0003122_maternal_imprinting1.79841590
24MP0003077_abnormal_cell_cycle1.78766301
25MP0008932_abnormal_embryonic_tissue1.77742489
26MP0003787_abnormal_imprinting1.76495126
27MP0003123_paternal_imprinting1.74653351
28MP0002938_white_spotting1.74188385
29MP0004957_abnormal_blastocyst_morpholog1.72661271
30MP0001905_abnormal_dopamine_level1.70878071
31MP0001697_abnormal_embryo_size1.67017675
32MP0003693_abnormal_embryo_hatching1.66984811
33MP0006035_abnormal_mitochondrial_morpho1.66197897
34MP0003938_abnormal_ear_development1.65830144
35MP0005380_embryogenesis_phenotype1.65737775
36MP0001672_abnormal_embryogenesis/_devel1.65737775
37MP0010030_abnormal_orbit_morphology1.61981755
38MP0010307_abnormal_tumor_latency1.49898255
39* MP0002080_prenatal_lethality1.49682180
40MP0004133_heterotaxia1.49472625
41MP0003806_abnormal_nucleotide_metabolis1.48175506
42MP0009379_abnormal_foot_pigmentation1.47999000
43MP0003937_abnormal_limbs/digits/tail_de1.46998063
44MP0002084_abnormal_developmental_patter1.46554056
45MP0006276_abnormal_autonomic_nervous1.45615530
46MP0001485_abnormal_pinna_reflex1.44981003
47MP0003567_abnormal_fetal_cardiomyocyte1.43068989
48MP0009672_abnormal_birth_weight1.43013038
49MP0002751_abnormal_autonomic_nervous1.41901933
50MP0008789_abnormal_olfactory_epithelium1.41432804
51MP0006072_abnormal_retinal_apoptosis1.41400329
52MP0003984_embryonic_growth_retardation1.40461063
53MP0002088_abnormal_embryonic_growth/wei1.35952825
54MP0001486_abnormal_startle_reflex1.34206620
55MP0000313_abnormal_cell_death1.32901914
56MP0003186_abnormal_redox_activity1.31669723
57MP0006036_abnormal_mitochondrial_physio1.30533669
58MP0000631_abnormal_neuroendocrine_gland1.30519149
59MP0000049_abnormal_middle_ear1.30358795
60MP0003315_abnormal_perineum_morphology1.30243902
61MP0005394_taste/olfaction_phenotype1.29616210
62MP0005499_abnormal_olfactory_system1.29616210
63MP0003786_premature_aging1.29196084
64MP0004142_abnormal_muscle_tone1.28971582
65MP0008007_abnormal_cellular_replicative1.26363486
66MP0002272_abnormal_nervous_system1.25491022
67MP0001929_abnormal_gametogenesis1.24536105
68MP0000537_abnormal_urethra_morphology1.24336624
69MP0004742_abnormal_vestibular_system1.23119450
70MP0003890_abnormal_embryonic-extraembry1.20555972
71MP0000358_abnormal_cell_content/1.19355947
72MP0003861_abnormal_nervous_system1.18708289
73MP0002736_abnormal_nociception_after1.18315611
74MP0002184_abnormal_innervation1.17238152
75MP0009745_abnormal_behavioral_response1.13818372
76MP0004197_abnormal_fetal_growth/weight/1.12771534
77MP0001968_abnormal_touch/_nociception1.12265900
78MP0002734_abnormal_mechanical_nocicepti1.11970726
79MP0002572_abnormal_emotion/affect_behav1.11621421
80MP0002735_abnormal_chemical_nociception1.11510183
81MP0000372_irregular_coat_pigmentation1.11340881
82MP0000026_abnormal_inner_ear1.10942457
83MP0001986_abnormal_taste_sensitivity1.10894817
84MP0003635_abnormal_synaptic_transmissio1.10721051
85MP0010352_gastrointestinal_tract_polyps1.10273515
86MP0002752_abnormal_somatic_nervous1.08851494
87MP0004270_analgesia1.08547328
88MP0002697_abnormal_eye_size1.05584236
89MP0000462_abnormal_digestive_system1.05277746
90MP0000653_abnormal_sex_gland1.04002589
91MP0002064_seizures1.03782775
92MP0001963_abnormal_hearing_physiology1.02448008
93MP0001346_abnormal_lacrimal_gland1.01749531
94MP0005253_abnormal_eye_physiology1.01103646
95MP0002653_abnormal_ependyma_morphology1.00036641
96MP0009046_muscle_twitch0.99701320
97MP0003385_abnormal_body_wall0.98793924
98MP0002086_abnormal_extraembryonic_tissu0.97609626
99MP0003119_abnormal_digestive_system0.97071513
100MP0002882_abnormal_neuron_morphology0.96725022
101MP0002063_abnormal_learning/memory/cond0.96170543
102MP0002111_abnormal_tail_morphology0.95953465
103MP0002067_abnormal_sensory_capabilities0.95561705
104MP0000955_abnormal_spinal_cord0.95095521
105MP0002557_abnormal_social/conspecific_i0.94341559
106MP0004859_abnormal_synaptic_plasticity0.93976512
107MP0002163_abnormal_gland_morphology0.93674627
108MP0002152_abnormal_brain_morphology0.93380104
109MP0001440_abnormal_grooming_behavior0.92948756
110MP0002210_abnormal_sex_determination0.92694722
111MP0002638_abnormal_pupillary_reflex0.92042277
112MP0003755_abnormal_palate_morphology0.91755059
113MP0004134_abnormal_chest_morphology0.91584733
114MP0009250_abnormal_appendicular_skeleto0.91474486
115MP0000015_abnormal_ear_pigmentation0.91423881
116MP0005551_abnormal_eye_electrophysiolog0.91196729
117MP0002019_abnormal_tumor_incidence0.90671086
118MP0008995_early_reproductive_senescence0.89594589
119MP0000920_abnormal_myelination0.89213395
120MP0002233_abnormal_nose_morphology0.88261187
121MP0001293_anophthalmia0.87610298
122MP0009703_decreased_birth_body0.87176837
123MP0002249_abnormal_larynx_morphology0.86991878
124MP0002160_abnormal_reproductive_system0.85934003
125MP0001727_abnormal_embryo_implantation0.84924476
126MP0002396_abnormal_hematopoietic_system0.84914809
127MP0001119_abnormal_female_reproductive0.84380352
128MP0000647_abnormal_sebaceous_gland0.83176700
129MP0002085_abnormal_embryonic_tissue0.82384140
130MP0005386_behavior/neurological_phenoty0.81100082
131MP0004924_abnormal_behavior0.81100082
132MP0002114_abnormal_axial_skeleton0.81059000
133MP0001286_abnormal_eye_development0.80143886
134MP0002116_abnormal_craniofacial_bone0.78586378
135MP0005501_abnormal_skin_physiology0.77713347
136MP0000762_abnormal_tongue_morphology0.77194980
137MP0004381_abnormal_hair_follicle0.77082438
138MP0001145_abnormal_male_reproductive0.77037561
139MP0002234_abnormal_pharynx_morphology0.76928110
140MP0003221_abnormal_cardiomyocyte_apopto0.76749750
141MP0000490_abnormal_crypts_of0.74216581
142MP0003698_abnormal_male_reproductive0.73625453
143MP0005395_other_phenotype0.71322282
144MP0002161_abnormal_fertility/fecundity0.66760545
145MP0001881_abnormal_mammary_gland0.65857961
146MP0005384_cellular_phenotype0.62978205
147MP0005391_vision/eye_phenotype0.62861909
148MP0001661_extended_life_span0.62444718
149MP0002092_abnormal_eye_morphology0.61551467
150MP0004233_abnormal_muscle_weight0.61386843
151MP0003699_abnormal_female_reproductive0.61278556
152MP0003943_abnormal_hepatobiliary_system0.59550940
153MP0005408_hypopigmentation0.58697134
154MP0004147_increased_porphyrin_level0.57750012
155MP0001177_atelectasis0.57475930
156MP0001764_abnormal_homeostasis0.56888709
157MP0003935_abnormal_craniofacial_develop0.55539157
158MP0000516_abnormal_urinary_system0.54139854

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17043781
2Abnormality of the labia minora (HP:0012880)3.12275057
3Cerebral hypomyelination (HP:0006808)3.01307617
4Chromsome breakage (HP:0040012)2.98858288
5Abnormality of the anterior horn cell (HP:0006802)2.91067672
6Degeneration of anterior horn cells (HP:0002398)2.91067672
7Colon cancer (HP:0003003)2.83800855
8Duplicated collecting system (HP:0000081)2.82753384
9Microvesicular hepatic steatosis (HP:0001414)2.81501695
10Multiple enchondromatosis (HP:0005701)2.75906920
11Abnormality of the renal collecting system (HP:0004742)2.66229555
12Ependymoma (HP:0002888)2.66006924
13Acute necrotizing encephalopathy (HP:0006965)2.64485059
14Increased nuchal translucency (HP:0010880)2.63059572
15Abnormality of the duodenum (HP:0002246)2.59914151
16Cortical dysplasia (HP:0002539)2.57874422
17Increased serum pyruvate (HP:0003542)2.55816284
18Abnormality of glycolysis (HP:0004366)2.55816284
19Abnormal lung lobation (HP:0002101)2.54773755
20Type I transferrin isoform profile (HP:0003642)2.51444838
21Birth length less than 3rd percentile (HP:0003561)2.50358851
22Nephroblastoma (Wilms tumor) (HP:0002667)2.46766033
23Myelodysplasia (HP:0002863)2.44538102
24Embryonal renal neoplasm (HP:0011794)2.39344625
25Breast hypoplasia (HP:0003187)2.38321662
26Abnormality of methionine metabolism (HP:0010901)2.37028772
27Lipid accumulation in hepatocytes (HP:0006561)2.33912783
28Absent radius (HP:0003974)2.33230673
29Duplication of thumb phalanx (HP:0009942)2.32759510
30Reticulocytopenia (HP:0001896)2.29740793
31Septo-optic dysplasia (HP:0100842)2.29723099
32Cerebral edema (HP:0002181)2.29590100
33Volvulus (HP:0002580)2.28857633
34Increased serum lactate (HP:0002151)2.28275623
35Hypoplastic pelvis (HP:0008839)2.27709896
36Hepatocellular necrosis (HP:0001404)2.27604703
37Aplasia involving forearm bones (HP:0009822)2.26597807
38Absent forearm bone (HP:0003953)2.26597807
39Abnormal number of incisors (HP:0011064)2.21542290
40Parakeratosis (HP:0001036)2.19500680
41Sloping forehead (HP:0000340)2.18443825
42Mitochondrial inheritance (HP:0001427)2.16133199
43Abnormality of the septum pellucidum (HP:0007375)2.16107348
44Supernumerary spleens (HP:0009799)2.15385620
45Abnormal mitochondria in muscle tissue (HP:0008316)2.14974173
46Progressive macrocephaly (HP:0004481)2.13693339
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.12952916
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12952916
49Abnormality of the carotid arteries (HP:0005344)2.12001973
50Absent septum pellucidum (HP:0001331)2.11847320
51Meckel diverticulum (HP:0002245)2.11604510
52Abnormal protein glycosylation (HP:0012346)2.11490795
53Abnormal glycosylation (HP:0012345)2.11490795
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11490795
55Abnormal protein N-linked glycosylation (HP:0012347)2.11490795
56Rhabdomyosarcoma (HP:0002859)2.08966251
57Carpal bone hypoplasia (HP:0001498)2.08223525
58Glioma (HP:0009733)2.07107415
59Abnormality of the ileum (HP:0001549)2.06975172
60Patellar aplasia (HP:0006443)2.05857510
61Hepatic necrosis (HP:0002605)2.04028685
62Abnormality of the preputium (HP:0100587)2.04023160
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03071571
64Preaxial hand polydactyly (HP:0001177)2.00873207
65Medial flaring of the eyebrow (HP:0010747)1.99791091
66Postnatal microcephaly (HP:0005484)1.99767152
67Intestinal atresia (HP:0011100)1.98860258
68Spastic diplegia (HP:0001264)1.97886387
69Horseshoe kidney (HP:0000085)1.96869919
70Reduced antithrombin III activity (HP:0001976)1.96435062
71Stenosis of the external auditory canal (HP:0000402)1.95373329
72Neoplasm of the colon (HP:0100273)1.94814127
73Asplenia (HP:0001746)1.94531166
74Pancytopenia (HP:0001876)1.94528669
75Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94065517
76Lactic acidosis (HP:0003128)1.93908453
77Vaginal atresia (HP:0000148)1.93855991
78Increased hepatocellular lipid droplets (HP:0006565)1.93746637
79Aplastic anemia (HP:0001915)1.93664664
80Ectopic kidney (HP:0000086)1.93469692
81Aplasia/Hypoplasia of the patella (HP:0006498)1.93090534
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.93067586
83Genital tract atresia (HP:0001827)1.92309194
84Esophageal atresia (HP:0002032)1.91409159
85Abnormality of serum amino acid levels (HP:0003112)1.90579724
86Selective tooth agenesis (HP:0001592)1.90394858
87Alacrima (HP:0000522)1.89923135
88Medulloblastoma (HP:0002885)1.89304257
89Sensory axonal neuropathy (HP:0003390)1.89193125
90Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88724517
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88724517
92Megaloblastic anemia (HP:0001889)1.88340019
93Leukodystrophy (HP:0002415)1.88030452
94Triphalangeal thumb (HP:0001199)1.87405911
95Secondary amenorrhea (HP:0000869)1.86051418
96Choanal atresia (HP:0000453)1.85212900
97Gait imbalance (HP:0002141)1.84926967
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84452146
99Decreased lacrimation (HP:0000633)1.84425149
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83989197
101Abnormality of the astrocytes (HP:0100707)1.83643346
102Astrocytoma (HP:0009592)1.83643346
103Increased CSF lactate (HP:0002490)1.83622491
104Anophthalmia (HP:0000528)1.81980726
105Aplasia/Hypoplasia of the spleen (HP:0010451)1.80418376
1063-Methylglutaconic aciduria (HP:0003535)1.80275376
107Gastrointestinal atresia (HP:0002589)1.80000946
108Morphological abnormality of the inner ear (HP:0011390)1.79157509
109Abnormality of DNA repair (HP:0003254)1.78526272
110Cupped ear (HP:0000378)1.78499432
111Adrenal hypoplasia (HP:0000835)1.77462570
112Macrocytic anemia (HP:0001972)1.76065689
113Renal Fanconi syndrome (HP:0001994)1.75099682
114Neoplasm of the adrenal gland (HP:0100631)1.75093692
115Duodenal stenosis (HP:0100867)1.74795858
116Small intestinal stenosis (HP:0012848)1.74795858
117Overfolded helix (HP:0000396)1.73575710
118Myelomeningocele (HP:0002475)1.73569409
119Absent epiphyses (HP:0010577)1.73526244
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73526244
121Sparse eyelashes (HP:0000653)1.73410253
122CNS hypomyelination (HP:0003429)1.73250884
123Abnormality of the pons (HP:0007361)1.72969068
124Proximal placement of thumb (HP:0009623)1.72822529
125Clubbing of toes (HP:0100760)1.72622462
126Respiratory difficulties (HP:0002880)1.72603460
127Partial duplication of thumb phalanx (HP:0009944)1.72140943
128Abnormality of cochlea (HP:0000375)1.71437581
129Congenital primary aphakia (HP:0007707)1.71315099
130Abnormality of chromosome stability (HP:0003220)1.70255044
131Exercise intolerance (HP:0003546)1.70160537
132Abnormality of the incisor (HP:0000676)1.70069615
133Hypoplasia of the pons (HP:0012110)1.69612199
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69326062
135Nephrogenic diabetes insipidus (HP:0009806)1.68590648
136Absent thumb (HP:0009777)1.68289943
137Abnormal hair whorl (HP:0010721)1.67840538
138Methylmalonic acidemia (HP:0002912)1.67807243
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.67140822
140Shoulder girdle muscle weakness (HP:0003547)1.66957716
141Bifid tongue (HP:0010297)1.66668241
142Abnormality of the umbilical cord (HP:0010881)1.66412373
143Anencephaly (HP:0002323)1.65878843
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.65808135
145Hyperalaninemia (HP:0003348)1.65609682
146True hermaphroditism (HP:0010459)1.65114976
147Pancreatic fibrosis (HP:0100732)1.64289532
148Optic disc pallor (HP:0000543)1.62563501
149Facial cleft (HP:0002006)1.61938290
150Molar tooth sign on MRI (HP:0002419)1.59898311
151Abnormality of midbrain morphology (HP:0002418)1.59898311
152Gastroesophageal reflux (HP:0002020)1.59314089
153Abnormality of the nasolacrimal system (HP:0000614)1.59006116
154Nasolacrimal duct obstruction (HP:0000579)1.58826338
155Limb dystonia (HP:0002451)1.58293495
156Protruding tongue (HP:0010808)1.58125118
157Abnormality of the lacrimal duct (HP:0011481)1.57396869
158Acute encephalopathy (HP:0006846)1.57026497
159Broad-based gait (HP:0002136)1.56681732
160Partial duplication of the phalanx of hand (HP:0009999)1.55642145
161Short tibia (HP:0005736)1.55358380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.23182674
2BUB13.17726399
3NEK13.13875758
4VRK23.07266373
5TNIK3.01819555
6SRPK12.76852720
7MKNK12.72285155
8CASK2.68871980
9WEE12.30930730
10CDC72.26788032
11TRIM282.23831655
12MKNK22.15172588
13PASK2.15081255
14PNCK2.10478821
15BCR2.08438337
16MARK11.95941602
17VRK11.94034717
18MAPK131.90044370
19STK391.77371500
20TSSK61.76964352
21UHMK11.67833214
22OXSR11.57801086
23PLK31.55128924
24TLK11.55046553
25NME21.50912620
26BMPR1B1.48101445
27TTK1.47610528
28DYRK21.46868591
29PLK41.44374432
30PBK1.41080260
31CLK11.40808345
32EPHA41.39897060
33TAF11.39074613
34PRPF4B1.35559877
35NUAK11.31383364
36CSNK1G31.29366061
37BRD41.28515488
38EIF2AK11.28290661
39NEK61.27106877
40CDK81.21144672
41PDK21.18348468
42PLK11.17332862
43CCNB11.15817824
44ZAK1.14212382
45EIF2AK31.14206346
46CDK191.14130227
47EIF2AK21.14070033
48ATR1.14059857
49MAP2K71.07625633
50YES11.06447391
51NME11.05788553
52DYRK31.05160108
53CHEK21.04011519
54IRAK21.00240331
55LIMK11.00236073
56BCKDK0.99798133
57PLK20.99239022
58CSNK1A1L0.96924087
59CDK70.94707223
60PKN10.94678928
61BRSK20.93320105
62SIK30.92316173
63CSNK1G10.87151231
64AURKA0.87048176
65ACVR1B0.85326436
66ADRBK20.84232144
67CHEK10.83944153
68CAMK2B0.83590089
69FGFR20.82658449
70WNK30.82489189
71MAP4K20.82001172
72PAK40.80387292
73ALK0.79659348
74NTRK20.77444448
75NTRK30.76701768
76ERBB30.76452793
77ERBB40.74316068
78SCYL20.74050380
79CSNK1G20.73140684
80AURKB0.69393137
81BRSK10.69059399
82STK40.69002094
83CDK30.66915876
84CDK10.65081020
85CDK180.64686914
86ATM0.64419427
87RPS6KA40.62785596
88BRAF0.62375812
89MST40.62310333
90MAP3K40.61786578
91AKT30.61331098
92IRAK40.60937388
93CDK140.59553185
94MAP3K100.59484273
95CDK150.59103115
96DYRK1A0.58158206
97MUSK0.57828495
98MAP3K120.57700424
99MAPKAPK50.57575636
100DAPK10.57267231
101CDK11A0.56806233
102ROCK20.56799306
103CSNK2A20.55346098
104STK100.55294036
105TESK20.54326624
106FGR0.53589274
107CDK20.51260610
108RPS6KA50.51086964
109MAP3K80.50986585
110CSNK1E0.49474158
111CDK40.49196968
112CSNK2A10.48853728
113STK30.45489388
114FGFR10.44729703
115PAK10.44444607
116RPS6KB20.43190003
117PRKCI0.41948796
118KSR10.41885583
119STK38L0.41022728
120CDK60.40955305
121SMG10.40065425
122BMPR20.39605883
123PRKDC0.37749810
124CAMK2A0.36254076
125GRK10.34554773
126TGFBR10.34217870
127CAMK2D0.33203812
128NEK20.33120103
129LATS10.30890013
130CDK90.27884137
131MINK10.26713700
132KDR0.26249636
133MST1R0.25596735
134FLT30.22673613

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.36690851
2DNA replication_Homo sapiens_hsa030303.25043502
3Mismatch repair_Homo sapiens_hsa034303.20728183
4Spliceosome_Homo sapiens_hsa030402.94060101
5Proteasome_Homo sapiens_hsa030502.93589332
6Ribosome_Homo sapiens_hsa030102.68759398
7Homologous recombination_Homo sapiens_hsa034402.68485496
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61600495
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59352983
10Oxidative phosphorylation_Homo sapiens_hsa001902.40382736
11Nucleotide excision repair_Homo sapiens_hsa034202.39916135
12Fanconi anemia pathway_Homo sapiens_hsa034602.32008858
13Basal transcription factors_Homo sapiens_hsa030222.26750636
14Non-homologous end-joining_Homo sapiens_hsa034502.25921975
15RNA transport_Homo sapiens_hsa030132.12882592
16Parkinsons disease_Homo sapiens_hsa050122.07215494
17Base excision repair_Homo sapiens_hsa034102.04441703
18Cell cycle_Homo sapiens_hsa041101.97461722
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91070500
20Pyrimidine metabolism_Homo sapiens_hsa002401.86071247
21Huntingtons disease_Homo sapiens_hsa050161.81585837
22Protein export_Homo sapiens_hsa030601.81049934
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78655225
24RNA degradation_Homo sapiens_hsa030181.72741960
25mRNA surveillance pathway_Homo sapiens_hsa030151.70664273
26Nicotine addiction_Homo sapiens_hsa050331.64813147
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.64760969
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57370747
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52430313
30Alzheimers disease_Homo sapiens_hsa050101.48319226
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47272549
32Pyruvate metabolism_Homo sapiens_hsa006201.45125501
33Biosynthesis of amino acids_Homo sapiens_hsa012301.42650369
34Propanoate metabolism_Homo sapiens_hsa006401.39608960
35Phototransduction_Homo sapiens_hsa047441.38883194
36Purine metabolism_Homo sapiens_hsa002301.29048925
37Carbon metabolism_Homo sapiens_hsa012001.19656567
38Axon guidance_Homo sapiens_hsa043601.18718322
39Selenocompound metabolism_Homo sapiens_hsa004501.10559750
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09054030
41Steroid biosynthesis_Homo sapiens_hsa001001.07613264
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06545045
43Ether lipid metabolism_Homo sapiens_hsa005651.06366863
44Alcoholism_Homo sapiens_hsa050341.01921069
45Serotonergic synapse_Homo sapiens_hsa047260.99940611
46Systemic lupus erythematosus_Homo sapiens_hsa053220.99205900
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98216464
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95442858
49Fatty acid elongation_Homo sapiens_hsa000620.95395174
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95345382
51Oocyte meiosis_Homo sapiens_hsa041140.92949527
52Folate biosynthesis_Homo sapiens_hsa007900.91741700
53Basal cell carcinoma_Homo sapiens_hsa052170.90186265
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89224673
55Sulfur relay system_Homo sapiens_hsa041220.86997417
56Epstein-Barr virus infection_Homo sapiens_hsa051690.85434881
57Hedgehog signaling pathway_Homo sapiens_hsa043400.83907052
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81601533
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79688319
60One carbon pool by folate_Homo sapiens_hsa006700.79533930
61Taste transduction_Homo sapiens_hsa047420.79024413
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77964116
63p53 signaling pathway_Homo sapiens_hsa041150.77885252
64Collecting duct acid secretion_Homo sapiens_hsa049660.71060878
65Cardiac muscle contraction_Homo sapiens_hsa042600.70806150
66Glutamatergic synapse_Homo sapiens_hsa047240.70108948
67Wnt signaling pathway_Homo sapiens_hsa043100.68795747
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68494877
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68085661
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67553128
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65951978
72Vibrio cholerae infection_Homo sapiens_hsa051100.62918037
73Pentose phosphate pathway_Homo sapiens_hsa000300.62410904
74Morphine addiction_Homo sapiens_hsa050320.60306209
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59895057
76Long-term depression_Homo sapiens_hsa047300.58947631
77Arachidonic acid metabolism_Homo sapiens_hsa005900.58940903
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57360939
79Sphingolipid metabolism_Homo sapiens_hsa006000.56857689
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55668897
81Amphetamine addiction_Homo sapiens_hsa050310.52674428
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51007797
83Dopaminergic synapse_Homo sapiens_hsa047280.50960700
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50752848
85Fatty acid metabolism_Homo sapiens_hsa012120.50336175
86GABAergic synapse_Homo sapiens_hsa047270.49389738
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48821332
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48491362
89Autoimmune thyroid disease_Homo sapiens_hsa053200.47889506
90Hippo signaling pathway_Homo sapiens_hsa043900.47160424
91Viral carcinogenesis_Homo sapiens_hsa052030.45549963
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45356003
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42078342
94Colorectal cancer_Homo sapiens_hsa052100.41947118
95Circadian entrainment_Homo sapiens_hsa047130.41285607
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41117888
97MicroRNAs in cancer_Homo sapiens_hsa052060.40562945
98Lysine degradation_Homo sapiens_hsa003100.39526439
99Linoleic acid metabolism_Homo sapiens_hsa005910.37612037
100Long-term potentiation_Homo sapiens_hsa047200.36979472
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.36622612
102Arginine and proline metabolism_Homo sapiens_hsa003300.36506160
103Sulfur metabolism_Homo sapiens_hsa009200.36402019
104Cocaine addiction_Homo sapiens_hsa050300.36335803
105Butanoate metabolism_Homo sapiens_hsa006500.36031508
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35083780
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34831761
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34676043
109Gap junction_Homo sapiens_hsa045400.32936679
110Peroxisome_Homo sapiens_hsa041460.32778837
111TGF-beta signaling pathway_Homo sapiens_hsa043500.32669919
112Tight junction_Homo sapiens_hsa045300.30645898
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29135942
114Synaptic vesicle cycle_Homo sapiens_hsa047210.28851400
115Thyroid cancer_Homo sapiens_hsa052160.28712245
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27789624
117Melanogenesis_Homo sapiens_hsa049160.26318704
118N-Glycan biosynthesis_Homo sapiens_hsa005100.25879476
119Metabolic pathways_Homo sapiens_hsa011000.25690865
120Cholinergic synapse_Homo sapiens_hsa047250.25486456
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.25451994
122Calcium signaling pathway_Homo sapiens_hsa040200.24572243
123Melanoma_Homo sapiens_hsa052180.24080797
124Pathways in cancer_Homo sapiens_hsa052000.23959015
125HTLV-I infection_Homo sapiens_hsa051660.23005039
126Ras signaling pathway_Homo sapiens_hsa040140.22201550
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21178097
128Prostate cancer_Homo sapiens_hsa052150.20921413
129Asthma_Homo sapiens_hsa053100.20853284
130Vitamin B6 metabolism_Homo sapiens_hsa007500.20655681
131Fatty acid degradation_Homo sapiens_hsa000710.20375719
132Fructose and mannose metabolism_Homo sapiens_hsa000510.19443243
133Glutathione metabolism_Homo sapiens_hsa004800.18868335
134beta-Alanine metabolism_Homo sapiens_hsa004100.18605317
135ErbB signaling pathway_Homo sapiens_hsa040120.17970017
136Phagosome_Homo sapiens_hsa041450.17163002
137Galactose metabolism_Homo sapiens_hsa000520.13921294
138Vitamin digestion and absorption_Homo sapiens_hsa049770.13275250
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.12926887
140Regulation of autophagy_Homo sapiens_hsa041400.10585161
141Adherens junction_Homo sapiens_hsa045200.05604933
142Tryptophan metabolism_Homo sapiens_hsa003800.04291721
143Legionellosis_Homo sapiens_hsa051340.02891474

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