ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	rRNA methylation (GO:0031167)	8.31650431
2	acrosome reaction (GO:0007340)	7.70690385
3	rRNA modification (GO:0000154)	7.39594797
4	single strand break repair (GO:0000012)	7.28936945
5	sperm motility (GO:0030317)	6.38553945
6	cell wall macromolecule metabolic process (GO:0044036)	6.04714011
7	cellular ketone body metabolic process (GO:0046950)	5.48438675
8	fusion of sperm to egg plasma membrane (GO:0007342)	5.10891000
9	centriole replication (GO:0007099)	4.93965298
10	ketone body metabolic process (GO:1902224)	4.87193681
11	sperm-egg recognition (GO:0035036)	4.83221068
12	rRNA catabolic process (GO:0016075)	4.69055546
13	protein targeting to Golgi (GO:0000042)	4.65119358
14	establishment of protein localization to Golgi (GO:0072600)	4.61908536
15	binding of sperm to zona pellucida (GO:0007339)	4.56393446
16	glomerular visceral epithelial cell development (GO:0072015)	4.54355875
17	spermatid nucleus differentiation (GO:0007289)	4.40272351
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.26590311
19	chromosome condensation (GO:0030261)	4.24826499
20	glycerol ether metabolic process (GO:0006662)	4.23022822
21	plasma membrane fusion (GO:0045026)	4.21056906
22	multicellular organism reproduction (GO:0032504)	4.17197516
23	DNA packaging (GO:0006323)	4.07519088
24	regulation of helicase activity (GO:0051095)	4.06706012
25	cellular response to ATP (GO:0071318)	4.06329801
26	protein localization to Golgi apparatus (GO:0034067)	4.05208248
27	glomerular epithelial cell development (GO:0072310)	4.04559180
28	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.01853811
29	cell-cell recognition (GO:0009988)	3.93938695
30	ether metabolic process (GO:0018904)	3.90087329
31	RNA destabilization (GO:0050779)	3.88265160
32	histone mRNA catabolic process (GO:0071044)	3.87630861
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.81940642
34	microtubule depolymerization (GO:0007019)	3.78388892
35	coenzyme catabolic process (GO:0009109)	3.74931969
36	calcium ion-dependent exocytosis (GO:0017156)	3.73361067
37	ncRNA catabolic process (GO:0034661)	3.71124430
38	chromatin silencing (GO:0006342)	3.67027741
39	spermatid development (GO:0007286)	3.65357434
40	male meiosis I (GO:0007141)	3.60999936
41	proteasome assembly (GO:0043248)	3.52750604
42	reproduction (GO:0000003)	3.51383635
43	sperm capacitation (GO:0048240)	3.48923244
44	spermatogenesis (GO:0007283)	3.48731241
45	male gamete generation (GO:0048232)	3.47934786
46	microtubule polymerization or depolymerization (GO:0031109)	3.46541866
47	phosphatidylethanolamine metabolic process (GO:0046337)	3.42279011
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.39270296
49	regulation of mitotic spindle checkpoint (GO:1903504)	3.38081105
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.38081105
51	glucosamine-containing compound catabolic process (GO:1901072)	3.35986241
52	DNA deamination (GO:0045006)	3.32502080
53	centriole assembly (GO:0098534)	3.32178266
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30385407
55	epithelial cilium movement (GO:0003351)	3.30172766
56	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.29835758
57	regulation of acrosome reaction (GO:0060046)	3.27548588
58	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.27305804
59	positive regulation of circadian rhythm (GO:0042753)	3.26917723
60	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.26633128
61	protein polyglutamylation (GO:0018095)	3.26382554
62	gamete generation (GO:0007276)	3.24083540
63	axonemal dynein complex assembly (GO:0070286)	3.21852205
64	growth hormone secretion (GO:0030252)	3.17548178
65	histone mRNA metabolic process (GO:0008334)	3.16190609
66	protein K63-linked deubiquitination (GO:0070536)	3.10213322
67	axoneme assembly (GO:0035082)	3.04555446
68	maturation of 5.8S rRNA (GO:0000460)	3.03023515
69	regulation of establishment of cell polarity (GO:2000114)	2.98586599
70	ovulation from ovarian follicle (GO:0001542)	2.96056903
71	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.95644546
72	regulation of centriole replication (GO:0046599)	2.90491309
73	peptidyl-histidine modification (GO:0018202)	2.90145580
74	regulation of chemokine secretion (GO:0090196)	2.86620902
75	lateral ventricle development (GO:0021670)	2.81887704
76	positive regulation of chemokine secretion (GO:0090197)	2.79170028
77	opsonization (GO:0008228)	2.79066657
78	cofactor catabolic process (GO:0051187)	2.76918285
79	positive regulation of growth hormone secretion (GO:0060124)	2.75411001
80	cullin deneddylation (GO:0010388)	2.75405704
81	pyrimidine dimer repair (GO:0006290)	2.75356914
82	prenylation (GO:0097354)	2.74664296
83	protein prenylation (GO:0018342)	2.74664296
84	DNA replication checkpoint (GO:0000076)	2.74593926
85	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.73442753
86	ether lipid metabolic process (GO:0046485)	2.72855919
87	L-fucose catabolic process (GO:0042355)	2.68879414
88	fucose catabolic process (GO:0019317)	2.68879414
89	L-fucose metabolic process (GO:0042354)	2.68879414
90	negative regulation of Rho protein signal transduction (GO:0035024)	2.67497492
91	cilium or flagellum-dependent cell motility (GO:0001539)	2.66663159
92	regulation of histone H3-K9 methylation (GO:0051570)	2.65772836
93	resolution of meiotic recombination intermediates (GO:0000712)	2.62585390
94	single fertilization (GO:0007338)	2.60763880
95	multicellular organismal reproductive process (GO:0048609)	2.56950410
96	seminiferous tubule development (GO:0072520)	2.51195366
97	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.50567958
98	arginine catabolic process (GO:0006527)	2.49385255
99	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.48821483
100	response to pheromone (GO:0019236)	10.1206134

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.48431983
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.28822824
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80521475
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.67514217
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57387119
6	P300_19829295_ChIP-Seq_ESCs_Human	2.51963204
7	VDR_22108803_ChIP-Seq_LS180_Human	2.43354658
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.37578525
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.22419163
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.12746768
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.12579992
12	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.08657427
13	EWS_26573619_Chip-Seq_HEK293_Human	2.08205225
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.00203862
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99461978
16	FUS_26573619_Chip-Seq_HEK293_Human	1.96184809
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.95166900
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.95166900
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92629916
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.92367031
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.90529623
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.89970555
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84147552
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.82268285
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81413686
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80418551
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80418551
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72895036
29	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.70470347
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64158421
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63108552
32	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.60629909
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60093090
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.58844010
35	NANOG_20526341_ChIP-Seq_ESCs_Human	1.57382997
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.56391200
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.56391200
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.56066837
39	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.53048333
40	HOXB7_26014856_ChIP-Seq_BT474_Human	1.51070696
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.50072098
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46872897
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46222355
44	NFYB_21822215_ChIP-Seq_K562_Human	1.45841195
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43773201
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41197009
47	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.40634007
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36492849
49	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.36288300
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35570852
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35536738
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35256962
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.34868521
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32200001
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.32167710
56	ETV1_20927104_ChIP-Seq_GIST48_Human	1.31409237
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.31068554
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.30323106
59	PHF8_20622853_ChIP-Seq_HELA_Human	1.30304820
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29247358
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29247358
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28875615
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.27959298
64	ERG_20517297_ChIP-Seq_VCAP_Human	1.27394500
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26972167
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.26371640
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25279808
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.24255531
69	NCOR_22424771_ChIP-Seq_293T_Human	1.23888097
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22700918
71	AR_25329375_ChIP-Seq_VCAP_Human	1.22199572
72	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.21839422
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.21646567
74	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21031537
75	STAT3_23295773_ChIP-Seq_U87_Human	1.18864929
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18280887
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18111735
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17597893
79	NFYA_21822215_ChIP-Seq_K562_Human	1.16708400
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15536855
81	TCF4_23295773_ChIP-Seq_U87_Human	1.15334784
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.15306107
83	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.15276542
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.12422670
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12393574
86	ERA_21632823_ChIP-Seq_H3396_Human	1.11511008
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10555434
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10081911
89	VDR_23849224_ChIP-Seq_CD4+_Human	1.09766091
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08697295
91	AR_20517297_ChIP-Seq_VCAP_Human	1.08668472
92	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07500022
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07379530
94	TBL1_22424771_ChIP-Seq_293T_Human	1.06859640
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.06706397
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06578832
97	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05329564
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04260895
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04257302
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03867863

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.94987125
2	MP0008057_abnormal_DNA_replication	4.42573299
3	MP0005167_abnormal_blood-brain_barrier	4.16592325
4	MP0008877_abnormal_DNA_methylation	3.13994284
5	MP0003011_delayed_dark_adaptation	3.04400725
6	MP0003878_abnormal_ear_physiology	3.03449204
7	MP0005377_hearing/vestibular/ear_phenot	3.03449204
8	MP0002138_abnormal_hepatobiliary_system	2.64812768
9	MP0005379_endocrine/exocrine_gland_phen	2.52752638
10	MP0005084_abnormal_gallbladder_morpholo	2.45152911
11	MP0003693_abnormal_embryo_hatching	2.40131089
12	MP0003698_abnormal_male_reproductive	2.37532005
13	MP0003646_muscle_fatigue	2.19386181
14	MP0006054_spinal_hemorrhage	2.18211056
15	MP0001929_abnormal_gametogenesis	2.17733745
16	MP0005645_abnormal_hypothalamus_physiol	2.15048305
17	MP0003718_maternal_effect	2.13084222
18	MP0002160_abnormal_reproductive_system	2.11018174
19	MP0005551_abnormal_eye_electrophysiolog	2.08705062
20	MP0001348_abnormal_lacrimal_gland	2.06694240
21	MP0004957_abnormal_blastocyst_morpholog	2.04470695
22	MP0001879_abnormal_lymphatic_vessel	2.02004742
23	MP0010368_abnormal_lymphatic_system	1.84529715
24	MP0002102_abnormal_ear_morphology	1.81938484
25	MP0005083_abnormal_biliary_tract	1.77417264
26	MP0001666_abnormal_nutrient_absorption	1.71551503
27	MP0008872_abnormal_physiological_respon	1.68998554
28	MP0005253_abnormal_eye_physiology	1.67385561
29	MP0000569_abnormal_digit_pigmentation	1.51903890
30	MP0005389_reproductive_system_phenotype	1.45421748
31	MP0002163_abnormal_gland_morphology	1.44388108
32	MP0008875_abnormal_xenobiotic_pharmacok	1.33472718
33	MP0001764_abnormal_homeostasis	1.32699923
34	MP0005220_abnormal_exocrine_pancreas	1.32426611
35	MP0008058_abnormal_DNA_repair	1.32027473
36	MP0004484_altered_response_of	1.28941870
37	MP0005408_hypopigmentation	1.24544254
38	MP0006036_abnormal_mitochondrial_physio	1.19170467
39	MP0002210_abnormal_sex_determination	1.19040859
40	MP0003828_pulmonary_edema	1.17147286
41	MP0005647_abnormal_sex_gland	1.17124379
42	MP0004215_abnormal_myocardial_fiber	1.16390539
43	MP0004742_abnormal_vestibular_system	1.15393136
44	MP0003567_abnormal_fetal_cardiomyocyte	1.14224043
45	MP0004084_abnormal_cardiac_muscle	1.13806104
46	MP0002161_abnormal_fertility/fecundity	1.12264197
47	MP0001984_abnormal_olfaction	1.11134596
48	MP0001968_abnormal_touch/_nociception	1.10788255
49	MP0004885_abnormal_endolymph	1.08544262
50	MP0000653_abnormal_sex_gland	1.06842200
51	MP0005085_abnormal_gallbladder_physiolo	1.04298411
52	MP0001661_extended_life_span	1.04112561
53	MP0009697_abnormal_copulation	1.02009434
54	MP0003252_abnormal_bile_duct	1.01625452
55	MP0003195_calcinosis	0.99923884
56	MP0005395_other_phenotype	0.98179257
57	MP0001145_abnormal_male_reproductive	0.97906447
58	MP0003787_abnormal_imprinting	0.96286462
59	MP0005266_abnormal_metabolism	0.92015321
60	MP0002254_reproductive_system_inflammat	0.90389725
61	MP0006276_abnormal_autonomic_nervous	0.89433031
62	MP0000470_abnormal_stomach_morphology	0.88302124
63	MP0003936_abnormal_reproductive_system	0.88150791
64	MP0002736_abnormal_nociception_after	0.87383763
65	MP0005670_abnormal_white_adipose	0.79345401
66	MP0004036_abnormal_muscle_relaxation	0.78957020
67	MP0000230_abnormal_systemic_arterial	0.77973999
68	MP0005646_abnormal_pituitary_gland	0.76977099
69	MP0009046_muscle_twitch	0.75557783
70	MP0001486_abnormal_startle_reflex	0.74590144
71	MP0001188_hyperpigmentation	0.72634600
72	MP0002229_neurodegeneration	0.72419013
73	MP0002837_dystrophic_cardiac_calcinosis	0.72005395
74	MP0004510_myositis	0.70174113
75	MP0002693_abnormal_pancreas_physiology	0.70104309
76	MP0002127_abnormal_cardiovascular_syste	0.69891929
77	MP0000358_abnormal_cell_content/	0.69817338
78	MP0001919_abnormal_reproductive_system	0.69595770
79	MP0009333_abnormal_splenocyte_physiolog	0.69401157
80	MP0001485_abnormal_pinna_reflex	0.67943026
81	MP0003941_abnormal_skin_development	0.67674692
82	MP0006035_abnormal_mitochondrial_morpho	0.67505584
83	MP0002282_abnormal_trachea_morphology	0.67104708
84	MP0002735_abnormal_chemical_nociception	0.66812091
85	MP0001501_abnormal_sleep_pattern	0.64617150
86	MP0000372_irregular_coat_pigmentation	0.64126036
87	MP0001756_abnormal_urination	0.63245366
88	MP0003943_abnormal_hepatobiliary_system	0.62380077
89	MP0002928_abnormal_bile_duct	0.62198993
90	MP0003638_abnormal_response/metabolism_	0.61893051
91	MP0002067_abnormal_sensory_capabilities	0.60993679
92	MP0005195_abnormal_posterior_eye	0.60630175
93	MP0004085_abnormal_heartbeat	0.59325867
94	MP0005636_abnormal_mineral_homeostasis	0.59001908
95	MP0006072_abnormal_retinal_apoptosis	0.58798567
96	MP0003119_abnormal_digestive_system	0.58506341
97	MP0005376_homeostasis/metabolism_phenot	0.58029629
98	MP0003077_abnormal_cell_cycle	0.57925683
99	MP0005391_vision/eye_phenotype	0.56669437
100	MP0000678_abnormal_parathyroid_gland	0.56432789

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	5.21551419
2	Pancreatic cysts (HP:0001737)	4.13392892
3	Hypoproteinemia (HP:0003075)	3.78486041
4	Submucous cleft hard palate (HP:0000176)	3.49530076
5	Abnormality of DNA repair (HP:0003254)	3.48338136
6	Neoplasm of the adrenal cortex (HP:0100641)	3.42117669
7	Decreased central vision (HP:0007663)	3.25387421
8	Abnormality of the renal cortex (HP:0011035)	3.24148465
9	Tubulointerstitial nephritis (HP:0001970)	3.22200330
10	Pendular nystagmus (HP:0012043)	3.20670610
11	Reduced antithrombin III activity (HP:0001976)	3.13413869
12	Broad alveolar ridges (HP:0000187)	3.07023711
13	Pancreatic fibrosis (HP:0100732)	3.04644785
14	Abnormality of the renal medulla (HP:0100957)	2.99953404
15	Tubular atrophy (HP:0000092)	2.99495577
16	Methylmalonic acidemia (HP:0002912)	2.96092876
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.89488337
18	Chronic hepatic failure (HP:0100626)	2.86360909
19	Cystic liver disease (HP:0006706)	2.83463154
20	Adrenal hypoplasia (HP:0000835)	2.79781771
21	Severe visual impairment (HP:0001141)	2.78710092
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.74810990
23	Nephronophthisis (HP:0000090)	2.74398357
24	Facial shape deformation (HP:0011334)	2.66264259
25	Potter facies (HP:0002009)	2.66264259
26	Keratoconus (HP:0000563)	2.64667892
27	Increased corneal curvature (HP:0100692)	2.64667892
28	Colon cancer (HP:0003003)	2.61299639
29	Tubulointerstitial abnormality (HP:0001969)	2.59487352
30	Entropion (HP:0000621)	2.53783476
31	Molar tooth sign on MRI (HP:0002419)	2.49650850
32	Abnormality of midbrain morphology (HP:0002418)	2.49650850
33	Hypoplasia of the pons (HP:0012110)	2.49056142
34	Pancreatic islet-cell hyperplasia (HP:0004510)	2.45749712
35	Enlarged kidneys (HP:0000105)	2.45280878
36	Duplicated collecting system (HP:0000081)	2.35768010
37	Sensory axonal neuropathy (HP:0003390)	2.33961866
38	Prostate neoplasm (HP:0100787)	2.33898336
39	Absent/shortened dynein arms (HP:0200106)	2.29249036
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29249036
41	Abnormality of the pons (HP:0007361)	2.28900796
42	Chorioretinal atrophy (HP:0000533)	2.28114081
43	Methylmalonic aciduria (HP:0012120)	2.20855883
44	True hermaphroditism (HP:0010459)	2.20815921
45	Genetic anticipation (HP:0003743)	2.20307674
46	Abnormality of the renal collecting system (HP:0004742)	2.20160381
47	Type I transferrin isoform profile (HP:0003642)	2.19903787
48	Azoospermia (HP:0000027)	2.17010117
49	Optic disc pallor (HP:0000543)	2.16858123
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15752678
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.15752678
52	Abnormality of the labia minora (HP:0012880)	2.13529488
53	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.13193475
54	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.08941892
55	Congenital, generalized hypertrichosis (HP:0004540)	2.08865725
56	Abnormality of macular pigmentation (HP:0008002)	2.08137410
57	Abnormal pancreas size (HP:0012094)	2.06643787
58	Progressive cerebellar ataxia (HP:0002073)	2.06278563
59	Hypophosphatemic rickets (HP:0004912)	2.05817750
60	Abolished electroretinogram (ERG) (HP:0000550)	2.03086034
61	Polyuria (HP:0000103)	2.03018319
62	Carpal bone hypoplasia (HP:0001498)	2.02489463
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.02020458
64	Abnormal urine output (HP:0012590)	2.01843398
65	Abnormal glucose tolerance (HP:0001952)	2.01584215
66	Visual hallucinations (HP:0002367)	2.00156119
67	Renal cortical cysts (HP:0000803)	2.00069503
68	Exotropia (HP:0000577)	1.99708090
69	Abnormality of vitamin B metabolism (HP:0004340)	1.98086405
70	Clubbing of toes (HP:0100760)	1.97374729
71	Impulsivity (HP:0100710)	1.95622805
72	Neoplasm of the adrenal gland (HP:0100631)	1.95298241
73	Abnormality of methionine metabolism (HP:0010901)	1.95209184
74	Focal motor seizures (HP:0011153)	1.94435789
75	Polydipsia (HP:0001959)	1.94108180
76	Abnormal drinking behavior (HP:0030082)	1.94108180
77	Poor coordination (HP:0002370)	1.92780117
78	Congenital stationary night blindness (HP:0007642)	1.90839571
79	Abnormality of the ileum (HP:0001549)	1.90172640
80	Hypochromic microcytic anemia (HP:0004840)	1.88953101
81	Oligohydramnios (HP:0001562)	1.88890356
82	Abnormal ciliary motility (HP:0012262)	1.87590317
83	Insulin-resistant diabetes mellitus (HP:0000831)	1.86857797
84	Tubulointerstitial fibrosis (HP:0005576)	1.86225897
85	Diastasis recti (HP:0001540)	1.85512256
86	Astigmatism (HP:0000483)	1.84957794
87	Meckel diverticulum (HP:0002245)	1.83823039
88	Bulbous nose (HP:0000414)	1.82004831
89	Long clavicles (HP:0000890)	1.80072897
90	3-Methylglutaconic aciduria (HP:0003535)	1.77678833
91	Glucose intolerance (HP:0000833)	1.77394395
92	Widely patent fontanelles and sutures (HP:0004492)	1.76921964
93	Absent thumb (HP:0009777)	1.74550690
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.73068714
95	Beaking of vertebral bodies (HP:0004568)	1.71946847
96	Esophageal atresia (HP:0002032)	1.71646340
97	Abnormal spermatogenesis (HP:0008669)	1.71439883
98	Infertility (HP:0000789)	1.70626033
99	Enlarged epiphyses (HP:0010580)	1.70571194
100	Glycosuria (HP:0003076)	1.69677348

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	3.96406078
2	VRK2	3.94434179
3	TAF1	3.84459020
4	PLK4	3.39857837
5	NUAK1	3.39713148
6	BMPR1B	2.93631937
7	ACVR1B	2.66082917
8	MAP3K12	2.58137704
9	FRK	2.57863776
10	TGFBR2	2.36634591
11	MAP4K2	2.34513404
12	SMG1	2.30089880
13	AKT3	2.21543206
14	PLK2	2.19692987
15	PIK3CG	2.17503914
16	TSSK6	2.12171372
17	INSRR	2.03302083
18	NME1	1.95127609
19	GRK5	1.93238437
20	CSNK1G3	1.67605928
21	MAPKAPK5	1.66252329
22	BUB1	1.58389539
23	GRK1	1.58088484
24	CSNK1A1L	1.57496719
25	STK38L	1.50358762
26	VRK1	1.49851988
27	PLK3	1.49062772
28	TGFBR1	1.49039600
29	CSNK1G2	1.39420413
30	EIF2AK3	1.38366856
31	ZAK	1.37278656
32	DYRK3	1.37143629
33	ADRBK2	1.36368150
34	MAPKAPK3	1.36020540
35	TLK1	1.34057943
36	CSNK1G1	1.33707446
37	TNIK	1.32836186
38	CAMKK2	1.31386773
39	NEK1	1.24945458
40	CDK9	1.08333148
41	ADRBK1	1.04210905
42	PTK2B	1.03656783
43	TEC	0.97727694
44	MAP4K1	0.92608158
45	DDR2	0.85402177
46	WNK3	0.82591071
47	FER	0.80453821
48	DYRK2	0.79799850
49	MAP3K11	0.79078404
50	GRK7	0.72439365
51	MKNK2	0.71276180
52	TESK1	0.70985471
53	TXK	0.69109831
54	MST4	0.66228373
55	STK24	0.63326795
56	EIF2AK2	0.63319087
57	DYRK1A	0.61886985
58	OXSR1	0.61539552
59	WNK1	0.60141723
60	BCKDK	0.57955798
61	EPHA4	0.52076972
62	PNCK	0.51798040
63	MAP3K2	0.50833615
64	PRKAA2	0.50479420
65	PBK	0.50444244
66	MAP3K5	0.48083107
67	DAPK1	0.47641791
68	CDK7	0.46587754
69	PRKCE	0.46445409
70	BRSK2	0.44227392
71	NEK9	0.44147655
72	MAP3K4	0.43788970
73	PASK	0.43197411
74	SRPK1	0.38790038
75	CAMK1G	0.38242689
76	IKBKB	0.37708088
77	FLT3	0.37363054
78	CAMK1D	0.36331528
79	MELK	0.33445371
80	OBSCN	0.32453200
81	MAP2K6	0.32305151
82	FGFR1	0.31743237
83	CHEK2	0.30150426
84	PLK1	0.29814189
85	MKNK1	0.29769561
86	KDR	0.28046860
87	TRIM28	0.27604285
88	PRKCG	0.26798797
89	PINK1	0.26509951
90	ATM	0.24932884
91	CSNK1D	0.24616052
92	STK3	0.23846466
93	CDC7	0.22846955
94	ATR	0.22830051
95	STK10	0.20748502
96	CAMK2A	0.20724888
97	MATK	0.20714003
98	RPS6KB2	0.20487578
99	PRKG1	0.19087655
100	ALK	0.18412489

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.61761829
2	Phototransduction_Homo sapiens_hsa04744	3.57009065
3	Proteasome_Homo sapiens_hsa03050	3.30851653
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.02883875
5	RNA degradation_Homo sapiens_hsa03018	2.57406576
6	Protein export_Homo sapiens_hsa03060	2.26016378
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18400292
8	Olfactory transduction_Homo sapiens_hsa04740	2.16239961
9	RNA transport_Homo sapiens_hsa03013	2.08676573
10	Homologous recombination_Homo sapiens_hsa03440	2.08410867
11	One carbon pool by folate_Homo sapiens_hsa00670	1.96675973
12	Butanoate metabolism_Homo sapiens_hsa00650	1.90529797
13	Propanoate metabolism_Homo sapiens_hsa00640	1.82497187
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.60463083
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.58023424
16	Arginine and proline metabolism_Homo sapiens_hsa00330	1.51520258
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48785413
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.48047954
19	Histidine metabolism_Homo sapiens_hsa00340	1.45490895
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.44824596
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.44258794
22	Taste transduction_Homo sapiens_hsa04742	1.38177205
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35335891
24	Base excision repair_Homo sapiens_hsa03410	1.34595647
25	Parkinsons disease_Homo sapiens_hsa05012	1.30468084
26	Circadian rhythm_Homo sapiens_hsa04710	1.28870989
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.25844324
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.20975280
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19189355
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.16678784
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15250716
32	Purine metabolism_Homo sapiens_hsa00230	1.12709789
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12404545
34	Allograft rejection_Homo sapiens_hsa05330	1.11156089
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.09422306
36	RNA polymerase_Homo sapiens_hsa03020	1.09253717
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.05121724
38	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04593019
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03649526
40	Arginine biosynthesis_Homo sapiens_hsa00220	1.01549094
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00382678
42	Huntingtons disease_Homo sapiens_hsa05016	0.99400923
43	Fatty acid degradation_Homo sapiens_hsa00071	0.98128636
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.97291812
45	Graft-versus-host disease_Homo sapiens_hsa05332	0.96478820
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.93969074
47	Peroxisome_Homo sapiens_hsa04146	0.93094875
48	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.92718507
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92230641
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91579357
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91193029
52	Regulation of autophagy_Homo sapiens_hsa04140	0.89398768
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89208276
54	Retinol metabolism_Homo sapiens_hsa00830	0.88836645
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88388758
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85961897
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.85933199
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81251300
59	Oocyte meiosis_Homo sapiens_hsa04114	0.79136272
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77335032
61	Alzheimers disease_Homo sapiens_hsa05010	0.76740096
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73952006
63	Mismatch repair_Homo sapiens_hsa03430	0.73711878
64	Mineral absorption_Homo sapiens_hsa04978	0.73011091
65	Spliceosome_Homo sapiens_hsa03040	0.72897175
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71744661
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71744161
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71680756
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69682660
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69497946
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66821601
72	Basal transcription factors_Homo sapiens_hsa03022	0.61912248
73	ABC transporters_Homo sapiens_hsa02010	0.59169450
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58988721
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58689814
76	Salivary secretion_Homo sapiens_hsa04970	0.58601272
77	Caffeine metabolism_Homo sapiens_hsa00232	0.58272683
78	Metabolic pathways_Homo sapiens_hsa01100	0.55771691
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52708976
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51668177
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.48923563
82	Antigen processing and presentation_Homo sapiens_hsa04612	0.48008968
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46301651
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.45031955
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.44845405
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44259723
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43269139
88	Pancreatic secretion_Homo sapiens_hsa04972	0.40461983
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38517075
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38189238
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37251224
92	DNA replication_Homo sapiens_hsa03030	0.37124854
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35820628
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35391882
95	Serotonergic synapse_Homo sapiens_hsa04726	0.35373150
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34000488
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32227866
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32176116
99	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.31907952
100	Adherens junction_Homo sapiens_hsa04520	0.31003254

ILF2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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