ILF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.61365857
2DNA unwinding involved in DNA replication (GO:0006268)4.61122018
3somatic hypermutation of immunoglobulin genes (GO:0016446)4.45262351
4somatic diversification of immune receptors via somatic mutation (GO:0002566)4.45262351
5kinetochore organization (GO:0051383)4.37591960
6mitotic metaphase plate congression (GO:0007080)4.32984775
7nuclear pore complex assembly (GO:0051292)4.26436355
8protein localization to kinetochore (GO:0034501)4.22009389
9spliceosomal tri-snRNP complex assembly (GO:0000244)4.17169826
10mitotic sister chromatid cohesion (GO:0007064)4.16820969
11regulation of RNA export from nucleus (GO:0046831)4.14444515
12nuclear pore organization (GO:0006999)4.13114866
13IMP biosynthetic process (GO:0006188)4.11849933
14protein localization to chromosome, centromeric region (GO:0071459)4.06377857
15mitotic sister chromatid segregation (GO:0000070)4.03888544
16pre-miRNA processing (GO:0031054)4.02143160
17mRNA stabilization (GO:0048255)4.01290474
18RNA stabilization (GO:0043489)4.01290474
19kinetochore assembly (GO:0051382)3.98128577
20sister chromatid segregation (GO:0000819)3.97390489
21DNA strand renaturation (GO:0000733)3.97084745
22regulation of translational fidelity (GO:0006450)3.89216106
23negative regulation of mRNA metabolic process (GO:1903312)3.86164673
24DNA strand elongation involved in DNA replication (GO:0006271)3.86062780
25meiotic chromosome segregation (GO:0045132)3.80049307
26metaphase plate congression (GO:0051310)3.78446681
27establishment of integrated proviral latency (GO:0075713)3.77521005
28regulation of mitotic spindle checkpoint (GO:1903504)3.77380099
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.77380099
30planar cell polarity pathway involved in neural tube closure (GO:0090179)3.69242233
31DNA strand elongation (GO:0022616)3.69166971
32paraxial mesoderm development (GO:0048339)3.64028869
33histone H2A acetylation (GO:0043968)3.59648185
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.58728712
35protein complex localization (GO:0031503)3.56415801
36regulation of spindle organization (GO:0090224)3.52706507
37regulation of nucleobase-containing compound transport (GO:0032239)3.51533064
38purine nucleobase biosynthetic process (GO:0009113)3.50609271
39telomere maintenance via semi-conservative replication (GO:0032201)3.50019577
40mitotic chromosome condensation (GO:0007076)3.48388281
41mitotic nuclear envelope disassembly (GO:0007077)3.47735033
42regulation of gene silencing by RNA (GO:0060966)3.45187131
43regulation of posttranscriptional gene silencing (GO:0060147)3.45187131
44regulation of gene silencing by miRNA (GO:0060964)3.45187131
45pore complex assembly (GO:0046931)3.44997800
46peptidyl-arginine omega-N-methylation (GO:0035247)3.44378653
47histone H4-K8 acetylation (GO:0043982)3.43157769
48histone H4-K5 acetylation (GO:0043981)3.43157769
49nucleobase biosynthetic process (GO:0046112)3.42749077
50DNA geometric change (GO:0032392)3.41994700
51CENP-A containing nucleosome assembly (GO:0034080)3.40718950
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.39902355
53DNA duplex unwinding (GO:0032508)3.39622498
54snRNA processing (GO:0016180)3.39039895
553-UTR-mediated mRNA stabilization (GO:0070935)3.38544228
56chromosome condensation (GO:0030261)3.38194497
57monoubiquitinated protein deubiquitination (GO:0035520)3.37528556
58mitotic recombination (GO:0006312)3.37315684
59chromatin remodeling at centromere (GO:0031055)3.36893711
60regulation of NFAT protein import into nucleus (GO:0051532)3.35850576
61establishment of chromosome localization (GO:0051303)3.34842567
62positive regulation of cellular response to oxidative stress (GO:1900409)3.34402998
63positive regulation of response to oxidative stress (GO:1902884)3.34402998
64IMP metabolic process (GO:0046040)3.34351045
65formation of translation preinitiation complex (GO:0001731)3.33984148
66attachment of spindle microtubules to kinetochore (GO:0008608)3.33558251
67nucleosome disassembly (GO:0006337)3.32355063
68protein-DNA complex disassembly (GO:0032986)3.32355063
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31478392
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29926704
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28893621
72DNA replication initiation (GO:0006270)3.27617526
73DNA replication checkpoint (GO:0000076)3.27276465
74DNA damage induced protein phosphorylation (GO:0006975)3.27265880
75viral mRNA export from host cell nucleus (GO:0046784)3.26452405
76nuclear envelope disassembly (GO:0051081)3.20988623
77membrane disassembly (GO:0030397)3.20988623
78DNA replication-independent nucleosome organization (GO:0034724)3.20313246
79DNA replication-independent nucleosome assembly (GO:0006336)3.20313246
80V(D)J recombination (GO:0033151)3.20043797
81regulation of telomere maintenance via telomerase (GO:0032210)3.19050092
82regulation of mRNA stability (GO:0043488)3.18940391
83dosage compensation (GO:0007549)3.18809330
84cellular protein complex localization (GO:0034629)3.18553488
85regulation of histone H3-K9 methylation (GO:0051570)3.17878485
86ATP-dependent chromatin remodeling (GO:0043044)3.17628423
87negative regulation of histone methylation (GO:0031061)3.16784807
88DNA topological change (GO:0006265)3.16635912
89chromatin assembly (GO:0031497)3.15433243
90regulation of helicase activity (GO:0051095)3.13892700
91regulation of DNA damage checkpoint (GO:2000001)3.12045160
92telomere maintenance via recombination (GO:0000722)3.07388469
93histone arginine methylation (GO:0034969)3.07222909
94regulation of histone H3-K27 methylation (GO:0061085)3.07140243
95mRNA transport (GO:0051028)3.05670689
96regulation of double-strand break repair via homologous recombination (GO:0010569)3.04606930
97convergent extension (GO:0060026)3.03941786
98snRNA metabolic process (GO:0016073)3.02991946
99negative regulation of mRNA processing (GO:0050686)3.02949899
100spindle checkpoint (GO:0031577)3.01556550
101ribosome biogenesis (GO:0042254)3.00101681
102protein export from nucleus (GO:0006611)2.99106547
103histone exchange (GO:0043486)2.98316785
104regulation of chromatin binding (GO:0035561)2.98076457
105positive regulation of cell cycle checkpoint (GO:1901978)2.97663653
106regulation of sister chromatid cohesion (GO:0007063)2.97499170
107peptidyl-arginine N-methylation (GO:0035246)2.97213934
108peptidyl-arginine methylation (GO:0018216)2.97213934
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.96632489
110regulation of RNA stability (GO:0043487)2.96339895
111protein localization to chromosome (GO:0034502)2.94237030
112chromosome segregation (GO:0007059)2.93807707
113DNA replication-dependent nucleosome organization (GO:0034723)2.93488518
114DNA replication-dependent nucleosome assembly (GO:0006335)2.93488518
115regulation of spindle checkpoint (GO:0090231)2.91762090
116regulation of mitotic spindle organization (GO:0060236)2.91502166
117DNA conformation change (GO:0071103)2.90872046
118telomere maintenance via telomere lengthening (GO:0010833)2.90827669
119mRNA splice site selection (GO:0006376)2.89448307
120positive regulation of chromosome segregation (GO:0051984)2.87710072
121nuclear envelope organization (GO:0006998)2.85985926
122mitotic spindle checkpoint (GO:0071174)2.85923883
123DNA synthesis involved in DNA repair (GO:0000731)2.85886593
124RNA splicing, via transesterification reactions (GO:0000375)2.85672441
125DNA packaging (GO:0006323)2.84755026
126RNA export from nucleus (GO:0006405)2.84445890
127replicative senescence (GO:0090399)2.84439801
128histone H4-K12 acetylation (GO:0043983)2.83314583
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83273986
130mRNA splicing, via spliceosome (GO:0000398)2.83273986
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82458843
132negative regulation of sister chromatid segregation (GO:0033046)2.82458843
133negative regulation of mitotic sister chromatid separation (GO:2000816)2.82458843
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82458843
135negative regulation of chromosome segregation (GO:0051985)2.82441060
136intracellular estrogen receptor signaling pathway (GO:0030520)2.81624675
137glucocorticoid receptor signaling pathway (GO:0042921)2.81332563
138spindle assembly checkpoint (GO:0071173)2.80743208
139proline biosynthetic process (GO:0006561)2.80526959
140negative regulation of RNA splicing (GO:0033119)2.79990419
141cellular response to epidermal growth factor stimulus (GO:0071364)2.77461138
142regulation of histone H3-K4 methylation (GO:0051569)2.75455680
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75358076
144regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73082882
145stress granule assembly (GO:0034063)2.68755181
146mRNA export from nucleus (GO:0006406)2.67782951
147regulation of histone methylation (GO:0031060)2.67594894
148peptidyl-lysine dimethylation (GO:0018027)2.67258185
149chromatin assembly or disassembly (GO:0006333)2.67254880
150positive regulation of DNA-dependent DNA replication (GO:2000105)2.65705052
151establishment of viral latency (GO:0019043)2.65314803
152RNA transport (GO:0050658)2.64718269
153establishment of RNA localization (GO:0051236)2.64718269
154nucleic acid transport (GO:0050657)2.64718269
155positive regulation of gene expression, epigenetic (GO:0045815)2.63873884
156histone H3-K36 demethylation (GO:0070544)2.61899991
157DNA ligation (GO:0006266)2.58832884
158adherens junction assembly (GO:0034333)2.58299389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.89259544
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.35088936
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.77765684
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.75198572
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.69296948
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.53191446
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.99500697
8* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69901460
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62943202
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55863707
11AR_21909140_ChIP-Seq_LNCAP_Human2.53170151
12* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.46241618
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.36399360
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.32782142
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27464122
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21867053
17YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20743962
18VDR_21846776_ChIP-Seq_THP-1_Human2.17597104
19* E2F1_21310950_ChIP-Seq_MCF-7_Human2.16802364
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16417545
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16128642
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14058040
23* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12697643
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09956082
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04251383
26CIITA_25753668_ChIP-Seq_RAJI_Human2.00656864
27E2F7_22180533_ChIP-Seq_HELA_Human10.9967296
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99275529
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96947565
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95016598
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92918858
32* XRN2_22483619_ChIP-Seq_HELA_Human1.91466727
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84637325
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82711383
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80602427
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80425503
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79442276
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77515550
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77427355
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.75687322
41* TTF2_22483619_ChIP-Seq_HELA_Human1.75231614
42* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70812726
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69837120
44* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67791800
45TCF7_22412390_ChIP-Seq_EML_Mouse1.64684186
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63966757
47* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.62423441
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61310671
49* FOXP3_21729870_ChIP-Seq_TREG_Human1.60524502
50* MYC_22102868_ChIP-Seq_BL_Human1.59236049
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58316484
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.58215978
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56029220
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54391177
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.52111101
56KDM2B_26808549_Chip-Seq_DND41_Human1.51097273
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50185952
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46400768
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46122499
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45531704
61VDR_23849224_ChIP-Seq_CD4+_Human1.40742272
62LXR_22292898_ChIP-Seq_THP-1_Human1.40488785
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37282616
64ELK1_19687146_ChIP-ChIP_HELA_Human1.35116729
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33164949
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32331292
67GABP_19822575_ChIP-Seq_HepG2_Human1.31070655
68* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29985143
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29693980
70CLOCK_20551151_ChIP-Seq_293T_Human1.29656778
71ZNF263_19887448_ChIP-Seq_K562_Human1.29597895
72KDM5A_27292631_Chip-Seq_BREAST_Human1.29322141
73RACK7_27058665_Chip-Seq_MCF-7_Human1.28379366
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27403824
75* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27389132
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26129099
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26078751
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.24978183
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21268354
80* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20742882
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20618619
82* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20383462
83KDM2B_26808549_Chip-Seq_K562_Human1.19258406
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17574124
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16982353
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16950065
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16937151
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16169477
89* SOX2_16153702_ChIP-ChIP_HESCs_Human1.16042328
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.15913296
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15395459
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.14188222
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13722313
94NCOR1_26117541_ChIP-Seq_K562_Human1.13527280
95CHD1_26751641_Chip-Seq_LNCaP_Human1.13438594
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12353831
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11736813
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11352016
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10734679
100* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10514483
101* DCP1A_22483619_ChIP-Seq_HELA_Human1.10041459
102* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08989700
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08537304
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08537304
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08537304
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08094051
107* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07907964
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07757329
109MYC_18940864_ChIP-ChIP_HL60_Human1.06271778
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04559322
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04263895
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01834000
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01385039
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00700515
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99577979
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99053857
117CREB1_26743006_Chip-Seq_LNCaP_Human0.98243331
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97989231
119MAF_26560356_Chip-Seq_TH1_Human0.96571642
120EWS_26573619_Chip-Seq_HEK293_Human0.96176336
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95963922
122* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95822508
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.95417344
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94842955
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94772372
126UTX_26944678_Chip-Seq_JUKART_Human0.94709241
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.94280983
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94280554
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94261126
130* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93983394
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93412912
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92304252
133P68_20966046_ChIP-Seq_HELA_Human0.92261101
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.87513771
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86651360
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86640503
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86388896
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85137179
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85071738
140TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84335708
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84205369
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82407209
143SRF_21415370_ChIP-Seq_HL-1_Mouse0.81280753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.10211261
2MP0010094_abnormal_chromosome_stability3.78674154
3MP0000537_abnormal_urethra_morphology3.66325084
4MP0008057_abnormal_DNA_replication3.51151608
5MP0003111_abnormal_nucleus_morphology3.41921017
6MP0008789_abnormal_olfactory_epithelium3.21856437
7MP0003693_abnormal_embryo_hatching3.20180635
8MP0008007_abnormal_cellular_replicative2.99784436
9MP0006292_abnormal_olfactory_placode2.95753587
10MP0003077_abnormal_cell_cycle2.91222870
11MP0003705_abnormal_hypodermis_morpholog2.89783677
12MP0008058_abnormal_DNA_repair2.85570292
13MP0005394_taste/olfaction_phenotype2.70939087
14MP0005499_abnormal_olfactory_system2.70939087
15MP0010030_abnormal_orbit_morphology2.45082105
16MP0004957_abnormal_blastocyst_morpholog2.43820716
17MP0008877_abnormal_DNA_methylation2.43417866
18MP0000566_synostosis2.14023420
19MP0003123_paternal_imprinting2.09878139
20MP0003121_genomic_imprinting2.05617289
21MP0002009_preneoplasia2.04144178
22MP0003119_abnormal_digestive_system1.89669578
23MP0001849_ear_inflammation1.87475676
24MP0000350_abnormal_cell_proliferation1.84805022
25MP0004185_abnormal_adipocyte_glucose1.84278381
26MP0003787_abnormal_imprinting1.83520327
27MP0009278_abnormal_bone_marrow1.77371951
28MP0008932_abnormal_embryonic_tissue1.71891406
29MP0005367_renal/urinary_system_phenotyp1.71767524
30MP0000516_abnormal_urinary_system1.71767524
31MP0000049_abnormal_middle_ear1.71115311
32MP0002638_abnormal_pupillary_reflex1.66446340
33MP0010352_gastrointestinal_tract_polyps1.65341623
34MP0001293_anophthalmia1.63386462
35MP0001730_embryonic_growth_arrest1.57666749
36MP0009053_abnormal_anal_canal1.57289187
37MP0002233_abnormal_nose_morphology1.51654391
38MP0004133_heterotaxia1.49979072
39MP0003890_abnormal_embryonic-extraembry1.49188210
40MP0004858_abnormal_nervous_system1.48417867
41MP0002877_abnormal_melanocyte_morpholog1.47699222
42MP0004233_abnormal_muscle_weight1.46777321
43MP0002085_abnormal_embryonic_tissue1.46524560
44MP0001672_abnormal_embryogenesis/_devel1.45911980
45MP0005380_embryogenesis_phenotype1.45911980
46MP0003786_premature_aging1.45904841
47MP0003937_abnormal_limbs/digits/tail_de1.45195585
48MP0003315_abnormal_perineum_morphology1.42600634
49MP0000678_abnormal_parathyroid_gland1.38274100
50MP0004197_abnormal_fetal_growth/weight/1.36346541
51MP0003942_abnormal_urinary_system1.35362187
52MP0001697_abnormal_embryo_size1.34969389
53MP0001346_abnormal_lacrimal_gland1.34259749
54MP0000534_abnormal_ureter_morphology1.33119532
55MP0002084_abnormal_developmental_patter1.30560787
56MP0000631_abnormal_neuroendocrine_gland1.29695181
57MP0002396_abnormal_hematopoietic_system1.29032826
58MP0001188_hyperpigmentation1.27735391
59MP0002111_abnormal_tail_morphology1.26478307
60MP0003941_abnormal_skin_development1.24782034
61MP0003567_abnormal_fetal_cardiomyocyte1.24545747
62MP0002751_abnormal_autonomic_nervous1.23866333
63MP0003385_abnormal_body_wall1.21495652
64MP0003984_embryonic_growth_retardation1.21304491
65MP0002088_abnormal_embryonic_growth/wei1.20361374
66MP0010386_abnormal_urinary_bladder1.19038325
67MP0003755_abnormal_palate_morphology1.18037686
68MP0004808_abnormal_hematopoietic_stem1.16820689
69MP0003861_abnormal_nervous_system1.16097283
70MP0002089_abnormal_postnatal_growth/wei1.16023827
71MP0001286_abnormal_eye_development1.15114270
72MP0003566_abnormal_cell_adhesion1.14387928
73* MP0009703_decreased_birth_body1.13062051
74MP0002210_abnormal_sex_determination1.11832710
75MP0003935_abnormal_craniofacial_develop1.09853413
76MP0000490_abnormal_crypts_of1.09713248
77MP0002080_prenatal_lethality1.08044324
78MP0000733_abnormal_muscle_development1.06670653
79MP0005451_abnormal_body_composition1.06319760
80MP0002116_abnormal_craniofacial_bone1.05272875
81* MP0000313_abnormal_cell_death1.04294744
82MP0003122_maternal_imprinting1.03694694
83MP0005623_abnormal_meninges_morphology1.02636256
84* MP0009672_abnormal_birth_weight1.01305467
85MP0002938_white_spotting1.00958925
86MP0005501_abnormal_skin_physiology1.00288923
87MP0003115_abnormal_respiratory_system1.00081116
88MP0005621_abnormal_cell_physiology1.00058591
89MP0000015_abnormal_ear_pigmentation0.99035462
90MP0000432_abnormal_head_morphology0.98785282
91MP0005409_darkened_coat_color0.98108857
92MP0000428_abnormal_craniofacial_morphol0.97201680
93MP0002086_abnormal_extraembryonic_tissu0.96966210
94MP0003718_maternal_effect0.96878617
95MP0004264_abnormal_extraembryonic_tissu0.95502757
96MP0002234_abnormal_pharynx_morphology0.95133940
97MP0010630_abnormal_cardiac_muscle0.94018011
98MP0001348_abnormal_lacrimal_gland0.93628970
99MP0002796_impaired_skin_barrier0.92764485
100MP0000579_abnormal_nail_morphology0.92726276
101MP0001119_abnormal_female_reproductive0.92559823
102MP0001299_abnormal_eye_distance/0.92150265
103MP0000703_abnormal_thymus_morphology0.91320282
104MP0005076_abnormal_cell_differentiation0.90501225
105MP0002092_abnormal_eye_morphology0.90484232
106MP0002114_abnormal_axial_skeleton0.89685380
107MP0000778_abnormal_nervous_system0.89468285
108MP0005666_abnormal_adipose_tissue0.89356034
109MP0010307_abnormal_tumor_latency0.88840095
110MP0001915_intracranial_hemorrhage0.88740894
111MP0003938_abnormal_ear_development0.86674811
112MP0001145_abnormal_male_reproductive0.85651548
113MP0002697_abnormal_eye_size0.84063343
114MP0000003_abnormal_adipose_tissue0.83694550
115MP0000653_abnormal_sex_gland0.83419232
116MP0005384_cellular_phenotype0.82782523
117MP0002925_abnormal_cardiovascular_devel0.81410258
118MP0005257_abnormal_intraocular_pressure0.79938815
119MP0002932_abnormal_joint_morphology0.79537612
120MP0002249_abnormal_larynx_morphology0.78648292
121MP0001929_abnormal_gametogenesis0.78550859
122MP0005408_hypopigmentation0.77920583
123MP0002177_abnormal_outer_ear0.76999354
124* MP0002081_perinatal_lethality0.75081692
125MP0003453_abnormal_keratinocyte_physiol0.73555811
126MP0000762_abnormal_tongue_morphology0.73501853
127MP0008260_abnormal_autophagy0.73332748
128MP0009250_abnormal_appendicular_skeleto0.72427482
129MP0001340_abnormal_eyelid_morphology0.72308519
130MP0000477_abnormal_intestine_morphology0.70123593
131MP0003943_abnormal_hepatobiliary_system0.69714505
132MP0005391_vision/eye_phenotype0.69293886
133MP0002160_abnormal_reproductive_system0.66897532
134MP0005248_abnormal_Harderian_gland0.66062544
135MP0004134_abnormal_chest_morphology0.65753531
136MP0002109_abnormal_limb_morphology0.63852669
137MP0002019_abnormal_tumor_incidence0.62971474

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)4.75042343
2Degeneration of anterior horn cells (HP:0002398)4.75042343
3Hyperacusis (HP:0010780)3.84952508
4Aplasia/Hypoplasia of the patella (HP:0006498)3.26085922
5Abnormality of the labia minora (HP:0012880)3.13349363
6Impulsivity (HP:0100710)2.97709702
7Colon cancer (HP:0003003)2.96197808
8Ectopic kidney (HP:0000086)2.95963544
9Rib fusion (HP:0000902)2.92504466
10Patellar aplasia (HP:0006443)2.92125631
11Abnormal lung lobation (HP:0002101)2.92122783
1211 pairs of ribs (HP:0000878)2.90512025
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.84865860
14Abnormality of the metopic suture (HP:0005556)2.83171718
15Trigonocephaly (HP:0000243)2.80622935
16Selective tooth agenesis (HP:0001592)2.76139688
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73715296
18Aplasia/Hypoplasia of the sternum (HP:0006714)2.71601088
19Nephroblastoma (Wilms tumor) (HP:0002667)2.70405619
20Chromsome breakage (HP:0040012)2.66372028
21Insomnia (HP:0100785)2.65813753
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58983606
23Short 4th metacarpal (HP:0010044)2.58983606
24Meckel diverticulum (HP:0002245)2.58445743
25Embryonal renal neoplasm (HP:0011794)2.56203981
26Urethral obstruction (HP:0000796)2.56002987
27Abnormality of the ileum (HP:0001549)2.46002149
28Broad distal phalanx of finger (HP:0009836)2.45502302
29Missing ribs (HP:0000921)2.45399097
30Ulnar bowing (HP:0003031)2.43092100
31Abnormality of the intervertebral disk (HP:0005108)2.42587512
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.42455626
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42455626
34Atrophy/Degeneration involving motor neurons (HP:0007373)2.42096821
35Abnormality of the preputium (HP:0100587)2.41256739
36Overriding aorta (HP:0002623)2.40420775
37Short 1st metacarpal (HP:0010034)2.34537200
38Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.34537200
39Abnormality of the calcaneus (HP:0008364)2.33838823
40Deviation of the thumb (HP:0009603)2.33786553
41Long palpebral fissure (HP:0000637)2.33482869
42Proximal placement of thumb (HP:0009623)2.33468402
43Shallow orbits (HP:0000586)2.32046019
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.31090696
45Shawl scrotum (HP:0000049)2.30016209
46Papillary thyroid carcinoma (HP:0002895)2.28487500
47Broad face (HP:0000283)2.27151493
48Pointed chin (HP:0000307)2.25874195
49Disproportionate tall stature (HP:0001519)2.25084048
50Cortical dysplasia (HP:0002539)2.23756421
51Dysphonia (HP:0001618)2.23136177
52Medulloblastoma (HP:0002885)2.22019322
53Sleep apnea (HP:0010535)2.21251684
54Spinal cord lesions (HP:0100561)2.19496545
55Syringomyelia (HP:0003396)2.19496545
56Turricephaly (HP:0000262)2.19289394
57Deep palmar crease (HP:0006191)2.18602493
58Volvulus (HP:0002580)2.16927158
59Pseudobulbar signs (HP:0002200)2.16916450
60Carpal bone hypoplasia (HP:0001498)2.16912052
61Deep philtrum (HP:0002002)2.16339229
62Birth length less than 3rd percentile (HP:0003561)2.15481595
63Elfin facies (HP:0004428)2.11955740
64Hepatoblastoma (HP:0002884)2.11066345
65Abnormality of chromosome stability (HP:0003220)2.10986344
66Intestinal atresia (HP:0011100)2.10978113
67Abnormality of cochlea (HP:0000375)2.10893315
68Duodenal stenosis (HP:0100867)2.10794219
69Small intestinal stenosis (HP:0012848)2.10794219
70Prominent metopic ridge (HP:0005487)2.10380250
71Dysmetric saccades (HP:0000641)2.10354048
72Asymmetry of the thorax (HP:0001555)2.10088892
73Long eyelashes (HP:0000527)2.10037542
74Facial hemangioma (HP:0000329)2.06660959
75Rectal fistula (HP:0100590)2.06459500
76Rectovaginal fistula (HP:0000143)2.06459500
77Intestinal fistula (HP:0100819)2.05116939
78Arnold-Chiari malformation (HP:0002308)2.04039626
79Vertebral arch anomaly (HP:0008438)2.03509056
80Obsessive-compulsive behavior (HP:0000722)2.01690555
81Sloping forehead (HP:0000340)2.00992702
82Cutaneous melanoma (HP:0012056)2.00320109
83Skull defect (HP:0001362)1.99816594
84Thin ribs (HP:0000883)1.99743670
85Protruding tongue (HP:0010808)1.99270774
86Myelodysplasia (HP:0002863)1.98650494
87Overlapping toe (HP:0001845)1.96559485
88Anal stenosis (HP:0002025)1.95384819
89Atresia of the external auditory canal (HP:0000413)1.94790685
90Increased nuchal translucency (HP:0010880)1.94355726
91Abnormality of the aortic arch (HP:0012303)1.93109062
92Heterotopia (HP:0002282)1.92361115
93Embryonal neoplasm (HP:0002898)1.92036848
94Abnormality of the 1st metacarpal (HP:0010009)1.91861544
95Septo-optic dysplasia (HP:0100842)1.90918159
96Duplication of thumb phalanx (HP:0009942)1.90438902
97Patellar dislocation (HP:0002999)1.90186521
98Absent eyebrow (HP:0002223)1.89047499
99Broad finger (HP:0001500)1.87440498
100Ependymoma (HP:0002888)1.86954837
101Metaphyseal cupping (HP:0003021)1.85966999
102Renovascular hypertension (HP:0100817)1.85817371
103Wide cranial sutures (HP:0010537)1.85742204
104Optic nerve coloboma (HP:0000588)1.85349572
105Shoulder girdle muscle weakness (HP:0003547)1.83822724
106Progressive muscle weakness (HP:0003323)1.82867721
107Abnormality of the corticospinal tract (HP:0002492)1.82666670
108Bronchomalacia (HP:0002780)1.82366821
109Ankyloglossia (HP:0010296)1.81922646
110Renal hypoplasia (HP:0000089)1.81020035
111Partial duplication of thumb phalanx (HP:0009944)1.80796354
112Dislocated radial head (HP:0003083)1.80201349
113Abnormality of the duodenum (HP:0002246)1.79787489
114Preauricular skin tag (HP:0000384)1.79706116
115Abnormality of the phalanges of the hallux (HP:0010057)1.79373106
116Pelvic girdle muscle weakness (HP:0003749)1.79160685
117High anterior hairline (HP:0009890)1.76045759
118Abnormality of the carotid arteries (HP:0005344)1.75941599
119Pendular nystagmus (HP:0012043)1.75547787
120Bicornuate uterus (HP:0000813)1.75390296
121Reticulocytopenia (HP:0001896)1.74730282
122Abnormality of chromosome segregation (HP:0002916)1.74333722
123Clitoromegaly (HP:0000057)1.74127051
124Obstructive sleep apnea (HP:0002870)1.73488589
125Breech presentation (HP:0001623)1.73272527
126Multiple enchondromatosis (HP:0005701)1.73213855
127Spina bifida occulta (HP:0003298)1.72681819
128Broad palm (HP:0001169)1.72383678
129Abnormality of the radial head (HP:0003995)1.72373953
130Large eyes (HP:0001090)1.71960496
131Absent eyelashes (HP:0000561)1.71833728
132Clubbing of toes (HP:0100760)1.71725830
133Broad phalanges of the hand (HP:0009768)1.71650470
134Abnormal number of incisors (HP:0011064)1.71447805
135Abnormality of the 4th metacarpal (HP:0010012)1.71390873
136Long clavicles (HP:0000890)1.71357290
137Acute lymphatic leukemia (HP:0006721)1.70887770
138Widely patent fontanelles and sutures (HP:0004492)1.70277202
139Renal duplication (HP:0000075)1.70203384
140Flared metaphyses (HP:0003015)1.69921321
141Synostosis of carpal bones (HP:0005048)1.69284844
142Bell-shaped thorax (HP:0001591)1.68559310
143Broad thumb (HP:0011304)1.68162719
144Squamous cell carcinoma (HP:0002860)1.68129097
145Hypospadias (HP:0000047)1.67247925
146Spastic diplegia (HP:0001264)1.67109087
147Cafe-au-lait spot (HP:0000957)1.66927598
148Facial cleft (HP:0002006)1.66240222
149Abnormality of the fingertips (HP:0001211)1.65844876
150Absent frontal sinuses (HP:0002688)1.65799893
151Progressive external ophthalmoplegia (HP:0000590)1.65601202
152Sandal gap (HP:0001852)1.65576640
153Precocious puberty (HP:0000826)1.65327033
154Morphological abnormality of the inner ear (HP:0011390)1.63807223
155Skin tags (HP:0010609)1.63482543
156Partial duplication of the phalanx of hand (HP:0009999)1.63265856
157Absent radius (HP:0003974)1.62747084
158Bowel incontinence (HP:0002607)1.61303373
159Abnormality of the salivary glands (HP:0010286)1.60185645
160Abnormality of the thoracic spine (HP:0100711)1.60109640
161Leiomyosarcoma (HP:0100243)1.59923067
162Uterine leiomyosarcoma (HP:0002891)1.59923067
163Generalized hypotonia (HP:0001290)1.59645636
164Choanal stenosis (HP:0000452)1.58648240
165Broad phalanx (HP:0006009)1.57593549
166Supernumerary ribs (HP:0005815)1.57346881
167Glossoptosis (HP:0000162)1.57203731
168Centrally nucleated skeletal muscle fibers (HP:0003687)1.56972944
169Abnormality of oral frenula (HP:0000190)1.56921648
170Sparse lateral eyebrow (HP:0005338)1.55252943
171Flat acetabular roof (HP:0003180)1.55048436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK14.45224836
2PNCK4.41752385
3SRPK14.09812777
4MAP3K104.08063460
5SMG14.04333824
6CDC73.87673840
7TRIB33.77600597
8EIF2AK13.12530594
9MKNK23.04379972
10AKT32.84535988
11PASK2.65493349
12PLK32.55860827
13NEK22.44929873
14PRPF4B2.19500692
15WEE12.13157000
16BUB12.12224671
17ERBB31.99747551
18TSSK61.91140388
19PLK41.87333508
20YES11.83974738
21PLK11.82891947
22FGFR41.79508392
23MAP2K31.77150864
24TTK1.71094175
25ATR1.65838518
26SGK21.61081207
27PRKD31.58105752
28SIK11.56690879
29TGFBR11.50695347
30CDK121.50051990
31ZAK1.47296193
32CHEK21.40325677
33PDGFRA1.39610704
34CAMK1D1.35227329
35CHEK11.34360176
36TAOK21.33540917
37AURKA1.31555477
38PLK21.31023284
39LATS21.26227356
40AURKB1.22012935
41CCNB11.19593376
42BRSK21.16373939
43TYRO31.16134588
44EIF2AK31.15824412
45CDK71.15783628
46BRD41.15556792
47NEK11.14681599
48PKN21.11825796
49VRK11.09503430
50ATM1.05887407
51SGK31.05690975
52VRK21.04960338
53MARK11.02119047
54* CDK21.02112693
55TAF11.01639136
56MAP2K61.00703817
57SIK20.97835687
58TTN0.97328449
59CAMK1G0.97175633
60MAPK130.95432724
61NME20.95188012
62BRAF0.94660063
63BRSK10.92366522
64RIPK10.90344962
65EPHB20.89892205
66CDK10.89566632
67IRAK30.85981860
68DYRK20.85692540
69FGFR20.84183793
70STK40.83480488
71SGK2230.83290226
72SGK4940.83290226
73STK38L0.82195599
74CLK10.80816014
75CDK90.77550219
76SCYL20.74228401
77ACVR1B0.73379751
78BMX0.70956244
79ALK0.70891047
80PTK60.70622182
81RPS6KA40.69300945
82MAP3K80.66705685
83NTRK10.66153995
84KSR20.64855231
85STK100.63646196
86CDK60.60993484
87MAP2K70.60954160
88CDK40.60489974
89LATS10.60026451
90RPS6KB10.57303022
91* MAPK140.56990650
92MARK20.56685184
93PAK20.56102837
94STK240.55792225
95SIK30.55144344
96RPS6KB20.54662740
97MAPK110.54191037
98CDK11A0.53477745
99CSNK2A10.52398877
100ICK0.51294919
101PTK20.49648619
102MAPK100.49436189
103PIM10.49356844
104STK30.49249497
105CDK150.48396564
106MAP3K130.48265659
107MAP2K20.47879869
108CSNK2A20.46796220
109MAP2K40.45870756
110TNK20.45062893
111RPS6KL10.44542223
112RPS6KC10.44542223
113UHMK10.43882939
114PRKDC0.43781008
115CDK180.43643040
116GSK3B0.42675706
117MAP3K40.42646155
118RPS6KA10.42194735
119* AKT10.41798469
120ERN10.41686861
121CHUK0.41620849
122MELK0.41223959
123PAK40.41131690
124CDC42BPA0.41110163
125EEF2K0.40909141
126CSNK1E0.39513335
127NTRK20.39482280
128RPS6KA20.37970581
129FGFR30.37913211
130MTOR0.37818412
131PRKCI0.35742406
132MAP3K90.35020840
133CDK140.34716440
134RPS6KA60.34361621
135MAPK90.34235855
136MAPK80.34009161
137FGFR10.33240553
138CAMK40.32491123
139CDK80.30640242
140MAPK10.29928151
141EPHA20.29084502
142DYRK30.28893854
143* EIF2AK20.26086197
144TLK10.25759194
145AKT20.25647874

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44210587
2Mismatch repair_Homo sapiens_hsa034304.17817287
3Base excision repair_Homo sapiens_hsa034103.69779512
4Spliceosome_Homo sapiens_hsa030403.38828105
5Homologous recombination_Homo sapiens_hsa034403.28545130
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08258729
7One carbon pool by folate_Homo sapiens_hsa006703.07137750
8RNA transport_Homo sapiens_hsa030133.03449798
9Non-homologous end-joining_Homo sapiens_hsa034502.98420824
10Cell cycle_Homo sapiens_hsa041102.94706275
11Fanconi anemia pathway_Homo sapiens_hsa034602.83051861
12Nucleotide excision repair_Homo sapiens_hsa034202.74866596
13mRNA surveillance pathway_Homo sapiens_hsa030152.72109226
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39218814
15Basal transcription factors_Homo sapiens_hsa030222.29683382
16RNA degradation_Homo sapiens_hsa030182.04366266
17RNA polymerase_Homo sapiens_hsa030201.91726545
18Biosynthesis of amino acids_Homo sapiens_hsa012301.67357731
19Proteasome_Homo sapiens_hsa030501.62974689
20p53 signaling pathway_Homo sapiens_hsa041151.59483789
21Pyrimidine metabolism_Homo sapiens_hsa002401.50814435
22Oocyte meiosis_Homo sapiens_hsa041141.45669423
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35229331
24Basal cell carcinoma_Homo sapiens_hsa052171.34607615
25Thyroid cancer_Homo sapiens_hsa052161.25546372
26MicroRNAs in cancer_Homo sapiens_hsa052061.23027013
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18582960
28Epstein-Barr virus infection_Homo sapiens_hsa051691.18278456
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15095386
30Pentose phosphate pathway_Homo sapiens_hsa000301.13986207
31Notch signaling pathway_Homo sapiens_hsa043301.13811779
32Colorectal cancer_Homo sapiens_hsa052101.13073590
33Hippo signaling pathway_Homo sapiens_hsa043901.11990811
34Herpes simplex infection_Homo sapiens_hsa051681.02580312
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00638591
36Renal cell carcinoma_Homo sapiens_hsa052110.97323467
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97077622
38Endometrial cancer_Homo sapiens_hsa052130.95974601
39Viral carcinogenesis_Homo sapiens_hsa052030.94662962
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94407066
41HTLV-I infection_Homo sapiens_hsa051660.94120094
42Selenocompound metabolism_Homo sapiens_hsa004500.90280200
43Purine metabolism_Homo sapiens_hsa002300.88964913
44VEGF signaling pathway_Homo sapiens_hsa043700.88607498
45Systemic lupus erythematosus_Homo sapiens_hsa053220.86841031
46Hedgehog signaling pathway_Homo sapiens_hsa043400.85838723
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85203475
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84644693
49Wnt signaling pathway_Homo sapiens_hsa043100.83057038
50Chronic myeloid leukemia_Homo sapiens_hsa052200.81634310
51Carbon metabolism_Homo sapiens_hsa012000.80898171
52Adherens junction_Homo sapiens_hsa045200.80773102
53AMPK signaling pathway_Homo sapiens_hsa041520.79691267
54Ribosome_Homo sapiens_hsa030100.78534152
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76728221
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.75571669
57Lysine degradation_Homo sapiens_hsa003100.74454073
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73799811
59N-Glycan biosynthesis_Homo sapiens_hsa005100.73000234
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72565715
61Choline metabolism in cancer_Homo sapiens_hsa052310.72394864
62Alcoholism_Homo sapiens_hsa050340.69434304
63B cell receptor signaling pathway_Homo sapiens_hsa046620.68646485
64Fructose and mannose metabolism_Homo sapiens_hsa000510.67017617
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65053306
66TGF-beta signaling pathway_Homo sapiens_hsa043500.64416783
67Small cell lung cancer_Homo sapiens_hsa052220.64269853
68Prostate cancer_Homo sapiens_hsa052150.63489240
69Pathways in cancer_Homo sapiens_hsa052000.61595696
70Pancreatic cancer_Homo sapiens_hsa052120.60846587
71Estrogen signaling pathway_Homo sapiens_hsa049150.58843568
72Viral myocarditis_Homo sapiens_hsa054160.58186268
73Inositol phosphate metabolism_Homo sapiens_hsa005620.56823834
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53729156
75Non-small cell lung cancer_Homo sapiens_hsa052230.53119968
76Focal adhesion_Homo sapiens_hsa045100.53027894
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.50995364
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50693307
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49276848
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47999006
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47963162
82Influenza A_Homo sapiens_hsa051640.47645954
83Melanoma_Homo sapiens_hsa052180.46681426
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46328239
85Acute myeloid leukemia_Homo sapiens_hsa052210.44025992
86Axon guidance_Homo sapiens_hsa043600.43690946
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.42836818
88FoxO signaling pathway_Homo sapiens_hsa040680.42648352
89Bladder cancer_Homo sapiens_hsa052190.41105766
90Apoptosis_Homo sapiens_hsa042100.41090753
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38112285
92Antigen processing and presentation_Homo sapiens_hsa046120.37147432
93Prion diseases_Homo sapiens_hsa050200.34534085
94Phototransduction_Homo sapiens_hsa047440.34373405
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33207340
96Measles_Homo sapiens_hsa051620.32474184
97Melanogenesis_Homo sapiens_hsa049160.32024102
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31984261
99ErbB signaling pathway_Homo sapiens_hsa040120.31440541
100Tight junction_Homo sapiens_hsa045300.28996027
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.27477374
102Prolactin signaling pathway_Homo sapiens_hsa049170.27389640
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25830469
104Glioma_Homo sapiens_hsa052140.24723189
105Proteoglycans in cancer_Homo sapiens_hsa052050.23442331
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.23371790
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23223311
108Legionellosis_Homo sapiens_hsa051340.23215180
109Shigellosis_Homo sapiens_hsa051310.21827626
110Hepatitis B_Homo sapiens_hsa051610.20569958
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16906020
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.16012274
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15811275
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.13480529
115mTOR signaling pathway_Homo sapiens_hsa041500.13258454
116Insulin signaling pathway_Homo sapiens_hsa049100.12403344
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12396313
118Taste transduction_Homo sapiens_hsa047420.12225749
119Long-term potentiation_Homo sapiens_hsa047200.12093142
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11927629
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11384844
122HIF-1 signaling pathway_Homo sapiens_hsa040660.10895747
123MAPK signaling pathway_Homo sapiens_hsa040100.10189742
124Rap1 signaling pathway_Homo sapiens_hsa040150.10028025
125Dopaminergic synapse_Homo sapiens_hsa047280.09900950
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09830322

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